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Jacques Kessl - Publications

Affiliations: 
Chemistry and Biochemistry The University of Southern Mississippi, Hattiesburg, MS, United States 
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27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Sun J, Kessl JJ. Optimizing the Multimerization Properties of Quinoline-Based Allosteric HIV-1 Integrase Inhibitors. Viruses. 16. PMID 38399977 DOI: 10.3390/v16020200  0.642
2022 Dinh LP, Sun J, Glenn CD, Patel K, Pigza JA, Donahue MG, Yet L, Kessl JJ. Multi-Substituted Quinolines as HIV-1 Integrase Allosteric Inhibitors. Viruses. 14. PMID 35891446 DOI: 10.3390/v14071466  0.63
2022 Adu-Ampratwum D, Pan Y, Koneru PC, Antwi J, Hoyte AC, Kessl J, Griffin PR, Kvaratskhelia M, Fuchs JR, Larue RC. Identification and Optimization of a Novel HIV-1 Integrase Inhibitor. Acs Omega. 7: 4482-4491. PMID 35155940 DOI: 10.1021/acsomega.1c06378  0.611
2021 Sun J, Patel K, Hume J, Pigza JA, Donahue MG, Kessl JJ. Optimized binding of substituted quinoline ALLINIs within the HIV-1 integrase oligomer. The Journal of Biological Chemistry. 100363. PMID 33539919 DOI: 10.1016/j.jbc.2021.100363  0.614
2018 Jentsch NG, Hart AP, Hume JD, Sun J, McNeely KA, Lama C, Pigza JA, Donahue MG, Kessl JJ. Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors. Acs Medicinal Chemistry Letters. 9: 1007-1012. PMID 30344908 DOI: 10.1021/Acsmedchemlett.8B00269  0.629
2018 Jentsch NG, Hume JD, Crull EB, Beauti SM, Pham AH, Pigza JA, Kessl JJ, Donahue MG. Quinolines from the cyclocondensation of isatoic anhydride with ethyl acetoacetate: preparation of ethyl 4-hydroxy-2-methylquinoline-3-carboxylate and derivatives. Beilstein Journal of Organic Chemistry. 14: 2529-2536. PMID 30344776 DOI: 10.3762/Bjoc.14.229  0.558
2018 Zhao XZ, Métifiot M, Kiselev E, Kessl JJ, Maddali K, Marchand C, Kvaratskhelia M, Pommier Y, Burke TR. HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence. Molecules (Basel, Switzerland). 23. PMID 30049955 DOI: 10.3390/molecules23081858  0.418
2016 Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. The Journal of Biological Chemistry. 291: 23569-23577. PMID 27645997 DOI: 10.1074/Jbc.M116.753384  0.623
2016 Patel PA, Kvaratskhelia N, Mansour Y, Antwi J, Feng L, Koneru P, Kobe MJ, Jena N, Shi G, Mohamed MS, Li C, Kessl JJ, Fuchs JR. Indole-based allosteric inhibitors of HIV-1 integrase. Bioorganic & Medicinal Chemistry Letters. PMID 27568085 DOI: 10.1016/J.Bmcl.2016.08.037  0.552
2016 Kessl JJ, Kutluay SB, Townsend D, Rebensburg S, Slaughter A, Larue RC, Shkriabai N, Bakouche N, Fuchs JR, Bieniasz PD, Kvaratskhelia M. HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis. Cell. 166: 1257-1268.e12. PMID 27565348 DOI: 10.1016/J.Cell.2016.07.044  0.356
2016 Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M. The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency. Acs Chemical Biology. 11: 1313-21. PMID 26910179 DOI: 10.1021/Acschembio.6B00167  0.56
2016 Kessl JJ, Sharma A, Kvaratskhelia M. Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase. Methods in Molecular Biology (Clifton, N.J.). 1354: 149-64. PMID 26714710 DOI: 10.1007/978-1-4939-3046-3_10  0.456
2015 Feng L, Larue RC, Slaughter A, Kessl JJ, Kvaratskhelia M. HIV-1 integrase multimerization as a therapeutic target. Current Topics in Microbiology and Immunology. 389: 93-119. PMID 25778682 DOI: 10.1007/82_2015_439  0.541
2014 Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology. 11: 100. PMID 25421939 DOI: 10.1186/S12977-014-0100-1  0.571
2014 Shkriabai N, Dharmarajan V, Slaughter A, Kessl JJ, Larue RC, Feng L, Fuchs JR, Griffin PR, Kvaratskhelia M. A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase. The Journal of Biological Chemistry. 289: 26430-40. PMID 25118283 DOI: 10.1074/jbc.M114.589572  0.458
2014 Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. A new class of multimerization selective inhibitors of HIV-1 integrase. Plos Pathogens. 10: e1004171. PMID 24874515 DOI: 10.1371/Journal.Ppat.1004171  0.624
2013 Sharma A, Larue RC, Plumb MR, Malani N, Male F, Slaughter A, Kessl JJ, Shkriabai N, Coward E, Aiyer SS, Green PL, Wu L, Roth MJ, Bushman FD, Kvaratskhelia M. BET proteins promote efficient murine leukemia virus integration at transcription start sites. Proceedings of the National Academy of Sciences of the United States of America. 110: 12036-41. PMID 23818621 DOI: 10.1073/Pnas.1307157110  0.334
2013 Engelman A, Kessl JJ, Kvaratskhelia M. Allosteric inhibition of HIV-1 integrase activity. Current Opinion in Chemical Biology. 17: 339-45. PMID 23647983 DOI: 10.1016/J.Cbpa.2013.04.010  0.512
2013 Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M. The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors. The Journal of Biological Chemistry. 288: 15813-20. PMID 23615903 DOI: 10.1074/Jbc.M112.443390  0.587
2013 Jurado KA, Wang H, Slaughter A, Feng L, Kessl JJ, Koh Y, Wang W, Ballandras-Colas A, Patel PA, Fuchs JR, Kvaratskhelia M, Engelman A. Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation. Proceedings of the National Academy of Sciences of the United States of America. 110: 8690-5. PMID 23610442 DOI: 10.1073/Pnas.1300703110  0.558
2012 Larue R, Gupta K, Wuensch C, Shkriabai N, Kessl JJ, Danhart E, Feng L, Taltynov O, Christ F, Van Duyne GD, Debyser Z, Foster MP, Kvaratskhelia M. Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2). The Journal of Biological Chemistry. 287: 34044-58. PMID 22872640 DOI: 10.1074/Jbc.M112.384669  0.524
2012 Kessl JJ, Jena N, Koh Y, Taskent-Sezgin H, Slaughter A, Feng L, de Silva S, Wu L, Le Grice SF, Engelman A, Fuchs JR, Kvaratskhelia M. Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors. The Journal of Biological Chemistry. 287: 16801-11. PMID 22437836 DOI: 10.1074/Jbc.M112.354373  0.621
2011 Kessl JJ, Li M, Ignatov M, Shkriabai N, Eidahl JO, Feng L, Musier-Forsyth K, Craigie R, Kvaratskhelia M. FRET analysis reveals distinct conformations of in tetramers in the presence of viral DNA or LEDGF/p75 Nucleic Acids Research. 39: 9009-9022. PMID 21771857 DOI: 10.1093/Nar/Gkr581  0.303
2009 Kessl JJ, McKee CJ, Eidahl JO, Shkriabai N, Katz A, Kvaratskhelia M. HIV-1 Integrase-DNA Recognition Mechanisms. Viruses. 1: 713-36. PMID 21994566 DOI: 10.3390/v1030713  0.38
2009 Kessl JJ, Eidahl JO, Shkriabai N, Zhao Z, McKee CJ, Hess S, Burke TR, Kvaratskhelia M. An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule. Molecular Pharmacology. 76: 824-32. PMID 19638533 DOI: 10.1124/mol.109.058883  0.519
2008 McKee CJ, Kessl JJ, Shkriabai N, Dar MJ, Engelman A, Kvaratskhelia M. Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein. The Journal of Biological Chemistry. 283: 31802-12. PMID 18801737 DOI: 10.1074/Jbc.M805843200  0.395
2008 Zhao Z, McKee CJ, Kessl JJ, Santos WL, Daigle JE, Engelman A, Verdine G, Kvaratskhelia M. Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding. The Journal of Biological Chemistry. 283: 5632-41. PMID 18093980 DOI: 10.1074/Jbc.M705241200  0.4
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