| Year |
Citation |
Score |
| 2024 |
Azzman N, Gill MSA, Hassan SS, Christ F, Debyser Z, Mohamed WAS, Ahemad N. Pharmacological advances in anti-retroviral therapy for human immunodeficiency virus-1 infection: A comprehensive review. Reviews in Medical Virology. 34: e2529. PMID 38520650 DOI: 10.1002/rmv.2529 |
0.371 |
|
| 2024 |
Pellaers E, Denis A, Debyser Z. New latency-promoting agents for a block-and-lock functional cure strategy. Current Opinion in Hiv and Aids. PMID 38457209 DOI: 10.1097/COH.0000000000000844 |
0.331 |
|
| 2024 |
Brouns T, Lux V, Van Belle S, Christ F, Veverka V, Debyser Z. The Impact of Lens Epithelium-Derived Growth Factor p75 Dimerization on Its Tethering Function. Cells. 13. PMID 38334618 DOI: 10.3390/cells13030227 |
0.32 |
|
| 2023 |
Bruggemans A, Vansant G, Van de Velde P, Debyser Z. The HIV-2 OGH double reporter virus shows that HIV-2 is less cytotoxic and less sensitive to reactivation from latency than HIV-1 in cell culture. Journal of Virus Eradication. 9: 100343. PMID 37701289 DOI: 10.1016/j.jve.2023.100343 |
0.385 |
|
| 2022 |
Pellaers E, Bhat A, Christ F, Debyser Z. Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV-Based Vectors and for a Cure for HIV-1 Infection. Viruses. 15. PMID 36680071 DOI: 10.3390/v15010032 |
0.35 |
|
| 2022 |
Janssens J, De Wit F, Parveen N, Debyser Z. Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site. Mbio. e0000722. PMID 35708287 DOI: 10.1128/mbio.00007-22 |
0.407 |
|
| 2021 |
Janssens J, Blokken J, Lampi Y, De Wit F, Zurnic Bonisch I, Nombela I, Van de Velde P, Van Remoortel B, Gijsbers R, Christ F, Debyser Z. CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import. Microbiology Spectrum. 9: e0133621. PMID 34612665 DOI: 10.1128/Spectrum.01336-21 |
0.394 |
|
| 2021 |
Debyser Z, Bruggemans A, Van Belle S, Janssens J, Christ F. LEDGINs, Inhibitors of the Interaction Between HIV-1 Integrase and LEDGF/p75, Are Potent Antivirals with a Potential to Cure HIV Infection. Advances in Experimental Medicine and Biology. 1322: 97-114. PMID 34258738 DOI: 10.1007/978-981-16-0267-2_4 |
0.403 |
|
| 2021 |
Tabasi M, Nombela I, Janssens J, Lahousse AP, Christ F, Debyser Z. Role of Transportin-SR2 in HIV-1 Nuclear Import. Viruses. 13. PMID 34064404 DOI: 10.3390/v13050829 |
0.359 |
|
| 2021 |
Janssens J, Bruggemans A, Christ F, Debyser Z. Towards a Functional Cure of HIV-1: Insight Into the Chromatin Landscape of the Provirus. Frontiers in Microbiology. 12: 636642. PMID 33868195 DOI: 10.3389/fmicb.2021.636642 |
0.381 |
|
| 2021 |
Bruggemans A, Vansant G, Balakrishnan M, Mitchell ML, Cai R, Christ F, Debyser Z. GS-9822, a preclinical LEDGIN candidate, displays a block-and-lock phenotype in cell culture. Antimicrobial Agents and Chemotherapy. PMID 33619061 DOI: 10.1128/AAC.02328-20 |
0.398 |
|
| 2020 |
Desimmie BA, Humbert M, Lescrinier E, Hendrix J, Vets S, Gijsbers R, Ruprecht RM, Dietrich U, Debyser Z, Christ F. Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33385332 DOI: 10.1016/j.ymthe.2020.12.021 |
0.321 |
|
| 2020 |
Schrijvers R, Rijck J, Demeulemeester J, Adachi N, Vets S, Ronen K, Christ F, Bushman FD, Debyser Z, Gijsbers R. Correction: LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs. Plos Pathogens. 16: e1008894. PMID 32870932 DOI: 10.1371/journal.ppat.1008894 |
0.316 |
|
| 2020 |
Rocha S, Hendrix J, Borrenberghs D, Debyser Z, Hofkens J. Imaging the Replication of Single Viruses: Lessons Learned from HIV and Future Challenges To Overcome. Acs Nano. PMID 32820634 DOI: 10.1021/Acsnano.0C06369 |
0.381 |
|
| 2020 |
Desimmie BA, Schrijvers R, Demeulemeester J, Borrenberghs D, Weydert C, Thys W, Vets S, Van Remoortel B, Hofkens J, De Rijck J, Hendrix J, Bannert N, Gijsbers R, Christ F, Debyser Z. Correction to: LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions. Retrovirology. 17: 22. PMID 32727499 DOI: 10.1186/S12977-020-00530-4 |
0.422 |
|
| 2020 |
Desimmie BA, Weydert C, Schrijvers R, Vets S, Demeulemeester J, Proost P, Paron I, De Rijck J, Mast J, Bannert N, Gijsbers R, Christ F, Debyser Z. Correction to: HIV-1 IN/Pol recruits LEDGF/p75 into viral particles. Retrovirology. 17: 23. PMID 32727480 DOI: 10.1186/S12977-020-00531-3 |
0.422 |
|
| 2020 |
Vansant G, Chen HC, Zorita E, Trejbalová K, Miklík D, Filion G, Debyser Z. The chromatin landscape at the HIV-1 provirus integration site determines viral expression. Nucleic Acids Research. PMID 32597987 DOI: 10.1093/Nar/Gkaa536 |
0.477 |
|
| 2020 |
Zurnic Bönisch I, Dirix L, Lemmens V, Borrenberghs D, De Wit F, Vernaillen F, Rocha S, Christ F, Hendrix J, Hofkens J, Debyser Z. Capsid labelled HIV to investigate the role of capsid during nuclear import and integration. Journal of Virology. PMID 31941774 DOI: 10.1128/Jvi.01024-19 |
0.372 |
|
| 2020 |
Vansant G, Bruggemans A, Janssens J, Debyser Z. Block-And-Lock Strategies to Cure HIV Infection. Viruses. 12. PMID 31936859 DOI: 10.3390/V12010084 |
0.455 |
|
| 2020 |
Shirvani P, Fassihi A, Saghaie L, Van Belle S, Debyser Z, Christ F. Synthesis, anti-HIV-1 and antiproliferative evaluation of novel 4-nitroimidazole derivatives combined with 5-hydroxy-4-pyridinone moiety Journal of Molecular Structure. 1202: 127344. DOI: 10.1016/J.Molstruc.2019.127344 |
0.467 |
|
| 2019 |
Vanderlinden W, Brouns T, Walker PU, Kolbeck PJ, Milles LF, Ott W, Nickels PC, Debyser Z, Lipfert J. The free energy landscape of retroviral integration. Nature Communications. 10: 4738. PMID 31628321 DOI: 10.1038/S41467-019-12649-W |
0.317 |
|
| 2019 |
Rodríguez-Mora S, De Wit F, García-Perez J, Bermejo M, López-Huertas MR, Mateos E, Martí P, Rocha S, Vigón L, Christ F, Debyser Z, Vílchez JJ, Coiras M, Alcamí J. The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection. Plos Pathogens. 15: e1007958. PMID 31465518 DOI: 10.1371/Journal.Ppat.1007958 |
0.458 |
|
| 2019 |
Sirous H, Chemi G, Gemma S, Butini S, Debyser Z, Christ F, Saghaie L, Brogi S, Fassihi A, Campiani G, Brindisi M. Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using Structure-Based Combinatorial Library Design Approach. Frontiers in Chemistry. 7: 574. PMID 31457006 DOI: 10.3389/Fchem.2019.00574 |
0.487 |
|
| 2019 |
De Wit F, Pillalamarri SR, Sebastián-Martín A, Venkatesham A, Van Aerschot A, Debyser Z. Design of reverse transcriptase-specific nucleosides to visualize early steps of HIV-1 replication by click labeling. The Journal of Biological Chemistry. PMID 31201270 DOI: 10.1074/Jbc.Ra118.007185 |
0.457 |
|
| 2019 |
Scala A, Piperno A, Micale N, Christ F, Debyser Z. Synthesis and Anti-HIV Profile of a Novel Tetrahydroindazolylbenzamide Derivative Obtained by Oxazolone Chemistry. Acs Medicinal Chemistry Letters. 10: 398-401. PMID 30996769 DOI: 10.1021/Acsmedchemlett.8B00511 |
0.476 |
|
| 2019 |
Vansant G, Vranckx LS, Zurnic I, Van Looveren D, Van de Velde P, Nobles C, Gijsbers R, Christ F, Debyser Z. Impact of LEDGIN treatment during virus production on residual HIV-1 transcription. Retrovirology. 16: 8. PMID 30940165 DOI: 10.1186/S12977-019-0472-3 |
0.503 |
|
| 2019 |
Vanhamel J, Bruggemans A, Debyser Z. Establishment of latent HIV-1 reservoirs: what do we really know? Journal of Virus Eradication. 5: 3-9. PMID 30800420 DOI: 10.1016/S2055-6640(20)30275-2 |
0.459 |
|
| 2019 |
Lampi Y, Van Looveren D, Vranckx LS, Thiry I, Bornschein S, Debyser Z, Gijsbers R. Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection. Scientific Reports. 9: 2389. PMID 30787394 DOI: 10.1038/S41598-019-38718-0 |
0.511 |
|
| 2019 |
Venkatesham A, Pillalamarri SR, De Wit F, Lescrinier E, Debyser Z, Van Aerschot A. Propargylated Purine Deoxynucleosides: New Tools for Fluorescence Imaging Strategies. Molecules (Basel, Switzerland). 24. PMID 30696094 DOI: 10.3390/Molecules24030468 |
0.455 |
|
| 2018 |
Debyser Z, Vansant G, Bruggemans A, Janssens J, Christ F. Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection. Viruses. 11. PMID 30587760 DOI: 10.3390/V11010012 |
0.482 |
|
| 2018 |
Sirous H, Fassihi A, Brogi S, Campiani G, Christ F, Debyser Z, Gemma S, Butini S, Chemi G, Grillo A, Zabihollahi R, Aghasadeghi MR, Saghaie L, Memarian HR. Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors. Medicinal Chemistry (Shariqah (United Arab Emirates)). PMID 30569867 DOI: 10.2174/1573406415666181219113225 |
0.474 |
|
| 2018 |
Borrenberghs D, Zurnic I, De Wit F, Acke A, Dirix L, Cereseto A, Debyser Z, Hendrix J. Post-mitotic BET-induced reshaping of integrase quaternary structure supports wild-type MLV integration. Nucleic Acids Research. PMID 30445610 DOI: 10.1093/Nar/Gky1157 |
0.336 |
|
| 2018 |
Madlala P, Van de Velde P, Van Remoortel B, Vets S, Van Wijngaerden E, Van Laethem K, Gijsbers R, Schrijvers R, Debyser Z. Analysis of HIV-1 infection in a controller-discordant couple. Journal of Virus Eradication. 4: 170-173. PMID 30050679 |
0.35 |
|
| 2018 |
Sharma S, Čermáková K, De Rijck J, Demeulemeester J, Fábry M, El Ashkar S, Van Belle S, Lepšík M, Tesina P, Duchoslav V, Novák P, Hubálek M, Srb P, Christ F, Řezáčová P, ... ... Debyser Z, et al. Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29997176 DOI: 10.1073/Pnas.1803909115 |
0.347 |
|
| 2018 |
Weydert C, van Heertum B, Dirix L, De Houwer S, De Wit F, Mast J, Husson SJ, Busschots K, König R, Gijsbers R, De Rijck J, Debyser Z. Y-box-binding protein 1 supports the early and late steps of HIV replication. Plos One. 13: e0200080. PMID 29995936 DOI: 10.1371/Journal.Pone.0200080 |
0.504 |
|
| 2018 |
Demeulemeester J, Blokken J, De Houwer S, Dirix L, Klaassen H, Marchand A, Chaltin P, Christ F, Debyser Z. Inhibitors of the integrase-transportin-SR2 interaction block HIV nuclear import. Retrovirology. 15: 5. PMID 29329553 DOI: 10.1186/S12977-018-0389-2 |
0.5 |
|
| 2018 |
El Ashkar S, Schwaller J, Pieters T, Goossens S, Demeulemeester J, Christ F, Van Belle S, Juge S, Boeckx N, Engelman A, Van Vlierberghe P, Debyser Z, De Rijck J. LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis. Blood. 131: 95-107. PMID 29084774 DOI: 10.1182/Blood-2017-05-786962 |
0.337 |
|
| 2018 |
Madlala P, Velde PVd, Remoortel BV, Vets S, Wijngaerden EV, Laethem KV, Gijsbers R, Schrijvers R, Debyser Z. Analysis of ex vivo HIV-1 infection in a controller-discordant couple. Journal of Virus Eradication. 4: 170-173. DOI: 10.1016/S2055-6640(20)30268-5 |
0.486 |
|
| 2017 |
Blokken J, De Rijck J, Christ F, Debyser Z. Protein-protein and protein-chromatin interactions of LEDGF/p75 as novel drug targets. Drug Discovery Today. Technologies. 24: 25-31. PMID 29233296 DOI: 10.1016/J.Ddtec.2017.11.002 |
0.35 |
|
| 2017 |
Hofmann S, Dehn S, Businger R, Bolduan S, Schneider M, Debyser Z, Brack-Werner R, Schindler M. Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication. Open Biology. 7. PMID 29021215 DOI: 10.1098/Rsob.170115 |
0.506 |
|
| 2017 |
El Ashkar S, Van Looveren D, Schenk F, Vranckx LS, Demeulemeester J, De Rijck J, Debyser Z, Modlich U, Gijsbers R. Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy. Molecular Therapy. Nucleic Acids. 7: 231-245. PMID 28624199 DOI: 10.1016/J.Omtn.2017.04.002 |
0.345 |
|
| 2017 |
Tsirkone VG, Blokken J, De Wit F, Breemans J, De Houwer S, Debyser Z, Christ F, Strelkov SV. N-terminal Half of Transportin SR2 Interacts with HIV Integrase. The Journal of Biological Chemistry. PMID 28356354 DOI: 10.1074/Jbc.M117.777029 |
0.466 |
|
| 2017 |
Saleh S, Vranckx L, Gijsbers R, Christ F, Debyser Z. Insight into HIV-2 latency may disclose strategies for a cure for HIV-1 infection. Journal of Virus Eradication. 3: 7-14. PMID 28275453 DOI: 10.1016/S2055-6640(20)30300-9 |
0.493 |
|
| 2016 |
Borrenberghs D, Dirix L, De Wit F, Rocha S, Blokken J, De Houwer S, Gijsbers R, Christ F, Hofkens J, Hendrix J, Debyser Z. Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear Entry. Scientific Reports. 6: 36485. PMID 27830755 DOI: 10.1038/Srep36485 |
0.469 |
|
| 2016 |
Vranckx LS, Demeulemeester J, Debyser Z, Gijsbers R. Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras. Plos One. 11: e0164167. PMID 27788138 DOI: 10.1371/Journal.Pone.0164167 |
0.359 |
|
| 2016 |
De Luca L, Agharbaoui FE, Gitto R, Buemi MR, Christ F, Debyser Z, Ferro S. Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein-protein Interaction Inhibitors. Molecular Informatics. 35: 460-73. PMID 27546050 DOI: 10.1002/Minf.201501034 |
0.409 |
|
| 2016 |
Vranckx LS, Demeulemeester J, Saleh S, Boll A, Vansant G, Schrijvers R, Weydert C, Battivelli E, Verdin E, Cereseto A, Christ F, Gijsbers R, Debyser Z. LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV. Ebiomedicine. 8: 248-64. PMID 27428435 DOI: 10.1016/J.Ebiom.2016.04.039 |
0.51 |
|
| 2016 |
Cermakova K, Weydert C, Christ F, De Rijck J, Debyser Z. Lessons Learned: HIV Points the Way Towards Precision Treatment of Mixed-Lineage Leukemia. Trends in Pharmacological Sciences. PMID 27290878 DOI: 10.1016/J.Tips.2016.05.005 |
0.407 |
|
| 2016 |
Billamboz M, Suchaud V, Bailly F, Lion C, Andréola ML, Christ F, Debyser Z, Cotelle P. 2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs) as human immunodeficiency virus type 1 integrase inhibitors: Influence of the alkylcarboxamide substitution of position 4. European Journal of Medicinal Chemistry. 117: 256-268. PMID 27105029 DOI: 10.1016/J.Ejmech.2016.03.083 |
0.412 |
|
| 2016 |
Quercioli V, Primio CD, Casini A, Mulder LC, Vranckx LS, Borrenberghs D, Gijsbers R, Debyser Z, Cereseto A. COMPARATIVE ANALYSIS OF HIV-1 AND MLV 3D NUCLEAR DISTRIBUTION. Journal of Virology. PMID 26962222 DOI: 10.1128/Jvi.03188-15 |
0.419 |
|
| 2016 |
Borrenberghs D, Dirix L, Rocha S, Hofkens J, Debyser Z, Hendrix J. FRET Reveals an Interplay of the HIV-1 Integrase Subunits during its Journey from the Cytoplasm into the Nucleus Biophysical Journal. 110: 647a. DOI: 10.1016/J.Bpj.2015.11.3465 |
0.462 |
|
| 2015 |
Gerits A, Vancraeyenest P, Vreysen S, Laramée ME, Michiels A, Gijsbers R, Van den Haute C, Moons L, Debyser Z, Baekelandt V, Arckens L, Vanduffel W. Serotype-dependent transduction efficiencies of recombinant adeno-associated viral vectors in monkey neocortex. Neurophotonics. 2: 031209. PMID 26839901 DOI: 10.1117/1.Nph.2.3.031209 |
0.316 |
|
| 2015 |
Christ F, Debyser Z. HIV-1 integrase inhibition: looking at cofactor interactions. Future Medicinal Chemistry. 7: 2407-10. PMID 26669900 DOI: 10.4155/Fmc.15.162 |
0.458 |
|
| 2015 |
Vidović D, Gijsbers R, Quiles Jimenez A, Dooley J, Van Den Haute C, Van der Perren A, Liston A, Baekelandt V, Debyser Z, Carlon MS. Non-invasive imaging reveals stable transgene expression in mouse airways after delivery of a non-integrating rAAV vector. Human Gene Therapy. PMID 26567984 DOI: 10.1089/Hum.2015.109. |
0.326 |
|
| 2015 |
Esposito F, Tintori C, Martini R, Christ F, Debyser Z, Ferrarese R, Cabiddu G, Corona A, Ceresola ER, Calcaterra A, Iovine V, Botta B, Clementi M, Canducci F, Botta M, et al. Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation. Chembiochem : a European Journal of Chemical Biology. PMID 26360521 DOI: 10.1002/Cbic.201500385 |
0.462 |
|
| 2015 |
Weydert C, De Rijck J, Christ F, Debyser Z. Targeting virus-host interactions of HIV replication. Current Topics in Medicinal Chemistry. PMID 26324041 DOI: 10.2174/1568026615666150901115106 |
0.459 |
|
| 2015 |
Tesina P, Čermáková K, Hořejší M, Procházková K, Fábry M, Sharma S, Christ F, Demeulemeester J, Debyser Z, Rijck JD, Veverka V, Řezáčová P. Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif. Nature Communications. 6: 7968. PMID 26245978 DOI: 10.1038/Ncomms8968 |
0.37 |
|
| 2015 |
Cuzzucoli Crucitti G, Pescatori L, Messore A, Madia VN, Pupo G, Saccoliti F, Scipione L, Tortorella S, Di Leva FS, Cosconati S, Novellino E, Debyser Z, Christ F, Costi R, Di Santo R. Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75. European Journal of Medicinal Chemistry. 101: 288-94. PMID 26150289 DOI: 10.1016/J.Ejmech.2015.06.036 |
0.387 |
|
| 2015 |
Ferro S, De Luca L, Agharbaoui FE, Christ F, Debyser Z, Gitto R. Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors. Bioorganic & Medicinal Chemistry. 23: 3208-14. PMID 25999203 DOI: 10.1016/J.Bmc.2015.04.072 |
0.367 |
|
| 2015 |
Desimmie BA, Weydert C, Schrijvers R, Vets S, Demeulemeester J, Proost P, Paron I, De Rijck J, Mast J, Bannert N, Gijsbers R, Christ F, Debyser Z. HIV-1 IN/Pol recruits LEDGF/p75 into viral particles. Retrovirology. 12: 16. PMID 25809198 DOI: 10.1186/S12977-014-0134-4 |
0.497 |
|
| 2015 |
Debyser Z, Schrijvers R. Five-drug antiretroviral therapy for primary HIV infection? The Lancet. Infectious Diseases. 15: 362-3. PMID 25701559 DOI: 10.1016/S1473-3099(14)71014-X |
0.404 |
|
| 2015 |
Debyser Z, Christ F, De Rijck J, Gijsbers R. Host factors for retroviral integration site selection. Trends in Biochemical Sciences. 40: 108-16. PMID 25555456 DOI: 10.1016/J.Tibs.2014.12.001 |
0.447 |
|
| 2015 |
Cuzzucoli Crucitti G, Pescatori L, Messore A, Madia VN, Pupo G, Saccoliti F, Scipione L, Tortorella S, Di Leva FS, Cosconati S, Novellino E, Debyser Z, Christ F, Costi R, Di Santo R. Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75 European Journal of Medicinal Chemistry. 101: 288-294. DOI: 10.1016/j.ejmech.2015.06.036 |
0.346 |
|
| 2014 |
Demeulemeester J, Vets S, Schrijvers R, Madlala P, De Maeyer M, De Rijck J, Ndung'u T, Debyser Z, Gijsbers R. HIV-1 integrase variants retarget viral integration and are associated with disease progression in a chronic infection cohort. Cell Host & Microbe. 16: 651-62. PMID 25525795 DOI: 10.1016/J.Chom.2014.09.016 |
0.476 |
|
| 2014 |
Aelvoet SA, Ibrahimi A, Macchi F, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V. Noninvasive bioluminescence imaging of α-synuclein oligomerization in mouse brain using split firefly luciferase reporters. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 16518-32. PMID 25471588 DOI: 10.1523/Jneurosci.4933-13.2014 |
0.307 |
|
| 2014 |
Zhang D, Debnath B, Yu S, Sanchez TW, Christ F, Liu Y, Debyser Z, Neamati N, Zhao G. Design and discovery of 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide inhibitors of HIV-1 integrase. Bioorganic & Medicinal Chemistry. 22: 5446-53. PMID 25150089 DOI: 10.1016/J.Bmc.2014.07.036 |
0.421 |
|
| 2014 |
El Ashkar S, De Rijck J, Demeulemeester J, Vets S, Madlala P, Cermakova K, Debyser Z, Gijsbers R. BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements. Molecular Therapy. Nucleic Acids. 3: e179. PMID 25072693 DOI: 10.1038/Mtna.2014.33 |
0.34 |
|
| 2014 |
De Houwer S, Demeulemeester J, Thys W, Rocha S, Dirix L, Gijsbers R, Christ F, Debyser Z. The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import. The Journal of Biological Chemistry. 289: 25351-61. PMID 25063804 DOI: 10.1074/Jbc.M113.533281 |
0.476 |
|
| 2014 |
Tsirkone VG, Beutels KG, Demeulemeester J, Debyser Z, Christ F, Strelkov SV. Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran. Acta Crystallographica. Section F, Structural Biology Communications. 70: 723-9. PMID 24915079 DOI: 10.1107/S2053230X14009492 |
0.331 |
|
| 2014 |
Schrijvers R, Debyser Z. Switching STRATEGIES in HIV treatment. The Lancet. Infectious Diseases. 14: 537-40. PMID 24908549 DOI: 10.1016/S1473-3099(14)70743-1 |
0.415 |
|
| 2014 |
Suchaud V, Bailly F, Lion C, Calmels C, Andréola ML, Christ F, Debyser Z, Cotelle P. Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors. Journal of Medicinal Chemistry. 57: 4640-60. PMID 24793360 DOI: 10.1021/Jm500109Z |
0.449 |
|
| 2014 |
Rogolino D, Carcelli M, Compari C, De Luca L, Ferro S, Fisicaro E, Rispoli G, Neamati N, Debyser Z, Christ F, Chimirri A. Diketoacid chelating ligands as dual inhibitors of HIV-1 integration process. European Journal of Medicinal Chemistry. 78: 425-30. PMID 24704615 DOI: 10.1016/J.Ejmech.2014.03.070 |
0.422 |
|
| 2014 |
Demeulemeester J, Chaltin P, Marchand A, De Maeyer M, Debyser Z, Christ F. LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014). Expert Opinion On Therapeutic Patents. 24: 609-32. PMID 24666332 DOI: 10.1517/13543776.2014.898753 |
0.483 |
|
| 2014 |
Borrenberghs D, Thys W, Rocha S, Demeulemeester J, Weydert C, Dedecker P, Hofkens J, Debyser Z, Hendrix J. HIV virions as nanoscopic test tubes for probing oligomerization of the integrase enzyme. Acs Nano. 8: 3531-45. PMID 24654558 DOI: 10.1021/Nn406615V |
0.491 |
|
| 2014 |
Ferro S, De Luca L, Lo Surdo G, Morreale F, Christ F, Debyser Z, Gitto R, Chimirri A. A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition. Bioorganic & Medicinal Chemistry. 22: 2269-79. PMID 24618511 DOI: 10.1016/J.Bmc.2014.02.012 |
0.481 |
|
| 2014 |
Carlon MS, Vidovi? D, Dooley J, da Cunha MM, Maris M, Lampi Y, Toelen J, Van den Haute C, Baekelandt V, Deprest J, Verbeken E, Liston A, Gijsbers R, Debyser Z. Immunological ignorance allows long-term gene expression after perinatal recombinant adeno-associated virus-mediated gene transfer to murine airways. Human Gene Therapy. 25: 517-28. PMID 24548076 DOI: 10.1089/Hum.2013.196 |
0.308 |
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| 2014 |
Ferro S, De Luca L, Morreale F, Christ F, Debyser Z, Gitto R, Chimirri A. Synthesis and biological evaluation of novel antiviral agents as protein-protein interaction inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 29: 237-42. PMID 23859152 DOI: 10.3109/14756366.2013.766609 |
0.34 |
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| 2014 |
Debyser Z, Desimmie BA, Taltynov O, Demeulemeester J, Christ F. Validation of host factors of HIV integration as novel drug targets for anti-HIV therapy Medchemcomm. 5: 314-320. DOI: 10.1039/C3Md00302G |
0.515 |
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| 2014 |
Borrenberghs D, thys W, Rocha S, Demeulemeester J, Dedecker P, Hofkens J, Debyser Z, Hendrix J. Probing Protein-Protein Interactions in a Single Virus: Application to HIV Integrase Oligomerization Biophysical Journal. 106: 61a. DOI: 10.1016/J.Bpj.2013.11.415 |
0.424 |
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| 2013 |
Billamboz M, Suchaud V, Bailly F, Lion C, Demeulemeester J, Calmels C, Andréola ML, Christ F, Debyser Z, Cotelle P. 4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors. Acs Medicinal Chemistry Letters. 4: 606-11. PMID 24900718 DOI: 10.1021/Ml400009T |
0.476 |
|
| 2013 |
Desimmie BA, Demeulemeester J, Christ F, Debyser Z. Rational design of LEDGINs as first allosteric integrase inhibitors for the treatment of HIV infection. Drug Discovery Today. Technologies. 10: e517-22. PMID 24451643 DOI: 10.1016/J.Ddtec.2012.10.002 |
0.483 |
|
| 2013 |
De Rijck J, de Kogel C, Demeulemeester J, Vets S, El Ashkar S, Malani N, Bushman FD, Landuyt B, Husson SJ, Busschots K, Gijsbers R, Debyser Z. The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites. Cell Reports. 5: 886-94. PMID 24183673 DOI: 10.1016/J.Celrep.2013.09.040 |
0.415 |
|
| 2013 |
Cavalluzzo C, Christ F, Voet A, Sharma A, Singh BK, Zhang KY, Lescrinier E, De Maeyer M, Debyser Z, Van der Eycken E. Identification of small peptides inhibiting the integrase-LEDGF/p75 interaction through targeting the cellular co-factor. Journal of Peptide Science : An Official Publication of the European Peptide Society. 19: 651-8. PMID 24014475 DOI: 10.1002/Psc.2543 |
0.41 |
|
| 2013 |
De Luca L, Morreale F, Christ F, Debyser Z, Ferro S, Gitto R. New scaffolds of natural origin as Integrase-LEDGF/p75 interaction inhibitors: virtual screening and activity assays. European Journal of Medicinal Chemistry. 68: 405-11. PMID 23994868 DOI: 10.1016/J.Ejmech.2013.07.025 |
0.379 |
|
| 2013 |
Serrao E, Xu ZL, Debnath B, Christ F, Debyser Z, Long YQ, Neamati N. Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction. Bioorganic & Medicinal Chemistry. 21: 5963-72. PMID 23985689 DOI: 10.1016/J.Bmc.2013.07.047 |
0.485 |
|
| 2013 |
Taltynov O, Demeulemeester J, Christ F, De Houwer S, Tsirkone VG, Gerard M, Weeks SD, Strelkov SV, Debyser Z. Interaction of transportin-SR2 with Ras-related nuclear protein (Ran) GTPase. The Journal of Biological Chemistry. 288: 25603-13. PMID 23878195 DOI: 10.1074/Jbc.M113.484345 |
0.448 |
|
| 2013 |
Long YQ, Huang SX, Zawahir Z, Xu ZL, Li H, Sanchez TW, Zhi Y, De Houwer S, Christ F, Debyser Z, Neamati N. Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors. Journal of Medicinal Chemistry. 56: 5601-12. PMID 23758584 DOI: 10.1021/Jm4006516 |
0.447 |
|
| 2013 |
Desimmie BA, Schrijvers R, Demeulemeester J, Borrenberghs D, Weydert C, Thys W, Vets S, Van Remoortel B, Hofkens J, De Rijck J, Hendrix J, Bannert N, Gijsbers R, Christ F, Debyser Z. LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions. Retrovirology. 10: 57. PMID 23721378 DOI: 10.1186/1742-4690-10-57 |
0.487 |
|
| 2013 |
Desimmie BA, Demeulemeester J, Suchaud V, Taltynov O, Billamboz M, Lion C, Bailly F, Strelkov SV, Debyser Z, Cotelle P, Christ F. 2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance. Acs Chemical Biology. 8: 1187-94. PMID 23517458 DOI: 10.1021/Cb4000426 |
0.459 |
|
| 2013 |
Di Primio C, Quercioli V, Allouch A, Gijsbers R, Christ F, Debyser Z, Arosio D, Cereseto A. Single-cell imaging of HIV-1 provirus (SCIP). Proceedings of the National Academy of Sciences of the United States of America. 110: 5636-41. PMID 23513220 DOI: 10.1073/Pnas.1216254110 |
0.465 |
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| 2013 |
Vets S, De Rijck J, Brendel C, Grez M, Bushman F, Debyser Z, Gijsbers R. Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD. Molecular Therapy. Nucleic Acids. 2: e77. PMID 23462964 DOI: 10.1038/Mtna.2013.4 |
0.361 |
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| 2013 |
Serrao E, Debnath B, Otake H, Kuang Y, Christ F, Debyser Z, Neamati N. Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction. Journal of Medicinal Chemistry. 56: 2311-22. PMID 23445471 DOI: 10.1021/Jm301632E |
0.413 |
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| 2013 |
Méreau H, De Rijck J, Cermáková K, Kutz A, Juge S, Demeulemeester J, Gijsbers R, Christ F, Debyser Z, Schwaller J. Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75). Leukemia. 27: 1245-53. PMID 23318960 DOI: 10.1038/Leu.2013.10 |
0.417 |
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| 2013 |
Sanchez TW, Debnath B, Christ F, Otake H, Debyser Z, Neamati N. Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions. Bioorganic & Medicinal Chemistry. 21: 957-63. PMID 23306052 DOI: 10.1016/J.Bmc.2012.12.012 |
0.395 |
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| 2013 |
Christ F, Debyser Z. The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy. Virology. 435: 102-9. PMID 23217620 DOI: 10.1016/J.Virol.2012.09.033 |
0.515 |
|
| 2013 |
Schrijvers R, Demeulemeester J, De Rijck J, Christ F, Gérard M, Debyser Z, Gijsbers R. Characterization of rare lens epithelium-derived growth factor/p75 genetic variants identified in HIV-1 long-term nonprogressors. Aids (London, England). 27: 539-43. PMID 23211777 DOI: 10.1097/Qad.0B013E32835D0D86 |
0.473 |
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| 2013 |
De Luca L, Ferro S, Morreale F, Christ F, Debyser Z, Chimirri A, Gitto R. Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 28: 1002-9. PMID 22803661 DOI: 10.3109/14756366.2012.703184 |
0.414 |
|
| 2013 |
Christ F, Demeulemeester J, Desimmie B, Suchaud V, Taltynov O, Lion C, Bailly F, Strelkov S, Cotelle P, Debyser Z. 2-Hydroxyisoquinoline-1,3(2H, 4H)diones (HQDs), novel inhibitors of the HIV integrase catalytic activity with a high barrier to resistance Retrovirology. 10. DOI: 10.1186/1742-4690-10-S1-P16 |
0.472 |
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| 2013 |
Debyser Z. LEDGINs, a novel class of antivirals targeting HIV integrase during integration and assembly Retrovirology. 10. DOI: 10.1186/1742-4690-10-S1-O44 |
0.49 |
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| 2013 |
De Riick J, de Kogel C, Demeulemeester J, Vets S, Malani N, Bushman FD, Busschots K, Husson S, Gijsbers R, Debyser Z. Bromodomain and extra-terminal (BET) proteins target Moloney murine leukemia virus integration to transcription start sites Retrovirology. 10. DOI: 10.1186/1742-4690-10-S1-O20 |
0.425 |
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| 2013 |
Boll A, Vranckx L, Di Primio C, Quercioli V, Gijsbers R, Debyser Z, Cereseto A. LEDGF/p75 controls 3D-localization of HIV-1 provirus in the nuclear compartment of infected cells Retrovirology. 10. DOI: 10.1186/1742-4690-10-S1-O10 |
0.455 |
|
| 2013 |
Christ F, Debyser Z. Corrigendum to The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy [Virology 435 (1) (2013) 102-109] Virology. 438: 50. DOI: 10.1016/J.Virol.2013.01.007 |
0.455 |
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| 2012 |
Aboye TL, Ha H, Majumder S, Christ F, Debyser Z, Shekhtman A, Neamati N, Camarero JA. Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity. Journal of Medicinal Chemistry. 55: 10729-34. PMID 23151033 DOI: 10.1021/Jm301468K |
0.467 |
|
| 2012 |
Carlon MS, Toelen J, da Cunha MM, Vidović D, Van der Perren A, Mayer S, Sbragia L, Nuyts J, Himmelreich U, Debyser Z, Deprest J. A novel surgical approach for intratracheal administration of bioactive agents in a fetal mouse model. Journal of Visualized Experiments : Jove. PMID 23149801 DOI: 10.3791/4219 |
0.316 |
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| 2012 |
Schrijvers R, Vets S, De Rijck J, Malani N, Bushman FD, Debyser Z, Gijsbers R. HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells. Retrovirology. 9: 84. PMID 23046603 DOI: 10.1186/1742-4690-9-84 |
0.487 |
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| 2012 |
Serrao E, Thys W, Demeulemeester J, Al-Mawsawi LQ, Christ F, Debyser Z, Neamati N. A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replication. Plos One. 7: e45177. PMID 23028829 DOI: 10.1371/Journal.Pone.0045177 |
0.431 |
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| 2012 |
Deroose CM, Chitneni SK, Gijsbers R, Vermaelen P, Ibrahimi A, Balzarini J, Baekelandt V, Verbruggen A, Nuyts J, Debyser Z, Bormans GM, Mortelmans L. Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET. Nuclear Medicine and Biology. 39: 1266-74. PMID 22981986 DOI: 10.1016/J.Nucmedbio.2012.06.014 |
0.311 |
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| 2012 |
Taltynov O, Desimmie BA, Demeulemeester J, Christ F, Debyser Z. Cellular cofactors of lentiviral integrase: from target validation to drug discovery. Molecular Biology International. 2012: 863405. PMID 22928108 DOI: 10.1155/2012/863405 |
0.491 |
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| 2012 |
Larue R, Gupta K, Wuensch C, Shkriabai N, Kessl JJ, Danhart E, Feng L, Taltynov O, Christ F, Van Duyne GD, Debyser Z, Foster MP, Kvaratskhelia M. Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2). The Journal of Biological Chemistry. 287: 34044-58. PMID 22872640 DOI: 10.1074/Jbc.M112.384669 |
0.467 |
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| 2012 |
De Houwer S, Demeulemeester J, Thys W, Taltynov O, Zmajkovicova K, Christ F, Debyser Z. Identification of residues in the C-terminal domain of HIV-1 integrase that mediate binding to the transportin-SR2 protein. The Journal of Biological Chemistry. 287: 34059-68. PMID 22872638 DOI: 10.1074/Jbc.M112.387944 |
0.431 |
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| 2012 |
Schrijvers R, Debyser Z. Combinational therapies for HIV: a focus on EVG/COBI/FTC/TDF. Expert Opinion On Pharmacotherapy. 13: 1969-83. PMID 22849516 DOI: 10.1517/14656566.2012.712514 |
0.439 |
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| 2012 |
Desimmie BA, Humbert M, Lescrinier E, Hendrix J, Vets S, Gijsbers R, Ruprecht RM, Dietrich U, Debyser Z, Christ F. Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 2064-75. PMID 22828501 DOI: 10.1038/Mt.2012.132 |
0.509 |
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| 2012 |
Christ F, Shaw S, Demeulemeester J, Desimmie BA, Marchand A, Butler S, Smets W, Chaltin P, Westby M, Debyser Z, Pickford C. Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization. Antimicrobial Agents and Chemotherapy. 56: 4365-74. PMID 22664975 DOI: 10.1128/Aac.00717-12 |
0.502 |
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| 2012 |
Suchaud V, Bailly F, Lion C, Tramontano E, Esposito F, Corona A, Christ F, Debyser Z, Cotelle P. Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity. Bioorganic & Medicinal Chemistry Letters. 22: 3988-92. PMID 22607675 DOI: 10.1016/J.Bmcl.2012.04.096 |
0.405 |
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| 2012 |
Tintori C, Demeulemeester J, Franchi L, Massa S, Debyser Z, Christ F, Botta M. Discovery of small molecule HIV-1 integrase dimerization inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 3109-14. PMID 22483582 DOI: 10.1016/J.Bmcl.2012.03.064 |
0.476 |
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| 2012 |
Schrijvers R, De Rijck J, Demeulemeester J, Adachi N, Vets S, Ronen K, Christ F, Bushman FD, Debyser Z, Gijsbers R. LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs. Plos Pathogens. 8: e1002558. PMID 22396646 DOI: 10.1371/Journal.Ppat.1002558 |
0.494 |
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| 2012 |
Demeulemeester J, Tintori C, Botta M, Debyser Z, Christ F. Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors. Journal of Biomolecular Screening. 17: 618-28. PMID 22337657 DOI: 10.1177/1087057111436343 |
0.423 |
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| 2012 |
Vets S, Kimpel J, Volk A, De Rijck J, Schrijvers R, Verbinnen B, Maes W, Von Laer D, Debyser Z, Gijsbers R. Lens epithelium-derived growth factor/p75 qualifies as a target for HIV gene therapy in the NSG mouse model. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 908-17. PMID 22334021 DOI: 10.1038/Mt.2012.6 |
0.477 |
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| 2012 |
Leoh LS, van Heertum B, De Rijck J, Filippova M, Rios-Colon L, Basu A, Martinez SR, Tungteakkhun SS, Filippov V, Christ F, De Leon M, Debyser Z, Casiano CA. The stress oncoprotein LEDGF/p75 interacts with the methyl CpG binding protein MeCP2 and influences its transcriptional activity. Molecular Cancer Research : McR. 10: 378-91. PMID 22275515 DOI: 10.1158/1541-7786.Mcr-11-0314 |
0.332 |
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| 2012 |
Yu S, Zhang L, Yan S, Wang P, Sanchez T, Christ F, Debyser Z, Neamati N, Zhao G. Nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity. Journal of Enzyme Inhibition and Medicinal Chemistry. 27: 628-40. PMID 22233539 DOI: 10.3109/14756366.2011.604851 |
0.402 |
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| 2012 |
Cavalluzzo C, Voet A, Christ F, Singh BK, Sharma A, Debyser Z, De Maeyer M, Van Der Eycken E. De novo design of small molecule inhibitors targeting the LEDGF/p75-HIV integrase interaction Rsc Advances. 2: 974-984. DOI: 10.1039/C1Ra00582K |
0.433 |
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| 2012 |
Demeulemeester J, Christ F, De Maeyer M, Debyser Z. Fueling HIV-1 integrase drug design with structural insights Drug Discovery Today: Technologies. 9: e205-e212. DOI: 10.1016/J.Ddtec.2012.05.005 |
0.436 |
|
| 2011 |
Gijsbers R, Vets S, De Rijck J, Ocwieja KE, Ronen K, Malani N, Bushman FD, Debyser Z. Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting. The Journal of Biological Chemistry. 286: 41812-25. PMID 21987578 DOI: 10.1074/Jbc.M111.255711 |
0.365 |
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| 2011 |
De Luca L, Gitto R, Christ F, Ferro S, De Grazia S, Morreale F, Debyser Z, Chimirri A. 4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process. Antiviral Research. 92: 102-7. PMID 21767569 DOI: 10.1016/J.Antiviral.2011.07.005 |
0.476 |
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| 2011 |
Schrijvers R, Desimmie BA, Debyser Z. Rilpivirine: a step forward in tailored HIV treatment. Lancet (London, England). 378: 201-3. PMID 21763920 DOI: 10.1016/S0140-6736(11)60992-6 |
0.434 |
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| 2011 |
McNeely M, Hendrix J, Busschots K, Boons E, Deleersnijder A, Gerard M, Christ F, Debyser Z. In vitro DNA tethering of HIV-1 integrase by the transcriptional coactivator LEDGF/p75. Journal of Molecular Biology. 410: 811-30. PMID 21763490 DOI: 10.1016/J.Jmb.2011.03.073 |
0.378 |
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| 2011 |
Maga G, Falchi F, Radi M, Botta L, Casaluce G, Bernardini M, Irannejad H, Manetti F, Garbelli A, Samuele A, Zanoli S, Esté JA, Gonzalez E, Zucca E, Paolucci S, ... ... Debyser Z, et al. Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation. Chemmedchem. 6: 1371-89. PMID 21698775 DOI: 10.1002/Cmdc.201100166 |
0.468 |
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| 2011 |
Madlala P, Gijsbers R, Christ F, Hombrouck A, Werner L, Mlisana K, An P, Abdool Karim SS, Winkler CA, Debyser Z, Ndung'u T. Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression. Aids (London, England). 25: 1711-9. PMID 21681054 DOI: 10.1097/Qad.0B013E328349C693 |
0.403 |
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| 2011 |
Billamboz M, Bailly F, Lion C, Touati N, Vezin H, Calmels C, Andréola ML, Christ F, Debyser Z, Cotelle P. Magnesium chelating 2-hydroxyisoquinoline-1,3(2H,4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: discovery of a novel selective inhibitor of the ribonuclease H function. Journal of Medicinal Chemistry. 54: 1812-24. PMID 21366258 DOI: 10.1021/Jm1014692 |
0.367 |
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| 2011 |
Van der Perren A, Toelen J, Carlon M, Van den Haute C, Coun F, Heeman B, Reumers V, Vandenberghe LH, Wilson JM, Debyser Z, Baekelandt V. Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9. Gene Therapy. 18: 517-27. PMID 21326331 DOI: 10.1038/Gt.2010.179 |
0.643 |
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| 2011 |
Thys W, De Houwer S, Demeulemeester J, Taltynov O, Vancraenenbroeck R, Gérard M, De Rijck J, Gijsbers R, Christ F, Debyser Z. Interplay between HIV entry and transportin-SR2 dependency. Retrovirology. 8: 7. PMID 21276267 DOI: 10.1186/1742-4690-8-7 |
0.488 |
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| 2011 |
Rinaldi M, Tintori C, Franchi L, Vignaroli G, Innitzer A, Massa S, Esté JA, Gonzalo E, Christ F, Debyser Z, Botta M. A versatile and practical synthesis toward the development of novel HIV-1 integrase inhibitors. Chemmedchem. 6: 343-52. PMID 21246739 DOI: 10.1002/Cmdc.201000510 |
0.455 |
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| 2011 |
De Luca L, De Grazia S, Ferro S, Gitto R, Christ F, Debyser Z, Chimirri A. HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation. European Journal of Medicinal Chemistry. 46: 756-64. PMID 21227550 DOI: 10.1016/J.Ejmech.2010.12.012 |
0.422 |
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| 2011 |
Billamboz M, Bailly F, Lion C, Calmels C, Andréola ML, Witvrouw M, Christ F, Debyser Z, De Luca L, Chimirri A, Cotelle P. 2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4. European Journal of Medicinal Chemistry. 46: 535-46. PMID 21185110 DOI: 10.1016/J.Ejmech.2010.11.033 |
0.378 |
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| 2011 |
Hendrix J, Gijsbers R, De Rijck J, Voet A, Hotta J, McNeely M, Hofkens J, Debyser Z, Engelborghs Y. The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering. Nucleic Acids Research. 39: 1310-25. PMID 20974633 DOI: 10.1093/Nar/Gkq933 |
0.346 |
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| 2011 |
Thys W, Bartholomeeusen K, Debyser Z, De Rijck J. Cellular Cofactors of HIV Integration Hiv-1 Integrase: Mechanism and Inhibitor Design. 105-129. DOI: 10.1002/9781118015377.ch9 |
0.351 |
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| 2011 |
Hombrouck A, Clayton R, Voet A, Witvrouw M, Debyser Z. Resistance to Inhibitors of HIV-1 Integrase Hiv-1 Integrase: Mechanism and Inhibitor Design. 477-498. DOI: 10.1002/9781118015377.ch30 |
0.321 |
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| 2011 |
Christ F, Busschots K, Mcneely M, Debyser Z, Hendrix J, Engelborghs Y. Assays for Evaluation of HIV-1 Integrase Enzymatic Activity, DNA Binding, and Cofactor Interaction Hiv-1 Integrase: Mechanism and Inhibitor Design. 151-163. DOI: 10.1002/9781118015377.ch12 |
0.305 |
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| 2010 |
Debyser Z, Christ F. On the cell biology of HIV integration from basic research to development of novel antiviral drugs Verhandelingen - Koninklijke Academie Voor Geneeskunde Van België. 72: 219-237. PMID 21409951 |
0.363 |
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| 2010 |
De Luca L, Ferro S, Gitto R, Barreca ML, Agnello S, Christ F, Debyser Z, Chimirri A. Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor. Bioorganic & Medicinal Chemistry. 18: 7515-21. PMID 20850978 DOI: 10.1016/J.Bmc.2010.08.051 |
0.451 |
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| 2010 |
Carlon M, Toelen J, Van der Perren A, Vandenberghe LH, Reumers V, Sbragia L, Gijsbers R, Baekelandt V, Himmelreich U, Wilson JM, Deprest J, Debyser Z. Efficient gene transfer into the mouse lung by fetal intratracheal injection of rAAV2/6.2. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 2130-8. PMID 20664525 DOI: 10.1038/Mt.2010.153 |
0.633 |
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| 2010 |
Ferro S, De Luca L, Barreca ML, De Grazia S, Christ F, Debyser Z, Chimirri A. New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action. Bioorganic & Medicinal Chemistry. 18: 5510-8. PMID 20630765 DOI: 10.1016/J.Bmc.2010.06.063 |
0.44 |
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| 2010 |
Maurin C, Lion C, Bailly F, Touati N, Vezin H, Mbemba G, Mouscadet JF, Debyser Z, Witvrouw M, Cotelle P. New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase--discovery of a new polyhydroxylated antiviral agent. Bioorganic & Medicinal Chemistry. 18: 5194-201. PMID 20541944 DOI: 10.1016/J.Bmc.2010.05.059 |
0.422 |
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| 2010 |
Lock M, Alvira M, Vandenberghe LH, Samanta A, Toelen J, Debyser Z, Wilson JM. Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale. Human Gene Therapy. 21: 1259-71. PMID 20497038 DOI: 10.1089/Hum.2010.055 |
0.635 |
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| 2010 |
De Rijck J, Bartholomeeusen K, Ceulemans H, Debyser Z, Gijsbers R. High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region. Nucleic Acids Research. 38: 6135-47. PMID 20484370 DOI: 10.1093/Nar/Gkq410 |
0.416 |
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| 2010 |
Christ F, Voet A, Marchand A, Nicolet S, Desimmie BA, Marchand D, Bardiot D, Van der Veken NJ, Van Remoortel B, Strelkov SV, De Maeyer M, Chaltin P, Debyser Z. Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. Nature Chemical Biology. 6: 442-8. PMID 20473303 DOI: 10.1038/Nchembio.370 |
0.504 |
|
| 2010 |
Gijsbers R, Ronen K, Vets S, Malani N, De Rijck J, McNeely M, Bushman FD, Debyser Z. LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 552-60. PMID 20195265 DOI: 10.1038/Mt.2010.36 |
0.351 |
|
| 2010 |
Schrijvers R, De Rijck J, Gijsbers R, Ronen K, Bushman F, Debyser Z. LEDGF/p75 is critical but not essential for multiple-round HIV 1 replication Journal of the International Aids Society. 13: O10. DOI: 10.1186/1758-2652-13-S3-O10 |
0.486 |
|
| 2010 |
Leoh LS, Rios-Colon L, Martinez S, Tungteakkhun S, Filippova M, Manuel L, Gijsbers R, Debyser Z, Casiano CA. Abstract 2945: Methyl CpG binding protein MeCP2 interacts with the stress-response transcription coactivator LEDGF/p75 and modulates its survival and transcription functions Cancer Research. 70: 2945-2945. DOI: 10.1158/1538-7445.Am10-2945 |
0.306 |
|
| 2010 |
Chimirri A, De Luca L, Ferro S, Gitto R, Monforte AM, Agnello S, Barreca ML, Christ F, Debyser Z. Small Molecules Targeting Protein–Protein Interactions: A Promising Anti-HIV Strategy Antiviral Research. 86: A32. DOI: 10.1016/J.Antiviral.2010.02.368 |
0.433 |
|
| 2009 |
Voet ARD, De Maeyer M, Debyser Z, Christ F. In search of second-generation HIV integrase inhibitors: Targeting integration beyond strand transfer Future Medicinal Chemistry. 1: 1259-1274. PMID 21426102 DOI: 10.4155/Fmc.09.86 |
0.459 |
|
| 2009 |
Vandenberghe LH, Breous E, Nam HJ, Gao G, Xiao R, Sandhu A, Johnston J, Debyser Z, Agbandje-McKenna M, Wilson JM. Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints. Gene Therapy. 16: 1416-28. PMID 19727141 DOI: 10.1038/Gt.2009.101 |
0.642 |
|
| 2009 |
De Luca L, Barreca ML, Ferro S, Christ F, Iraci N, Gitto R, Monforte AM, Debyser Z, Chimirri A. Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75 Chemmedchem. 4: 1311-1316. PMID 19565598 DOI: 10.1002/Cmdc.200900070 |
0.495 |
|
| 2009 |
Rajamaki S, Innitzer A, Falciani C, Tintori C, Christ F, Witvrouw M, Debyser Z, Massa S, Botta M. Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 3615-8. PMID 19447621 DOI: 10.1016/J.Bmcl.2009.04.132 |
0.434 |
|
| 2009 |
Bartholomeeusen K, Christ F, Hendrix J, Rain JC, Emiliani S, Benarous R, Debyser Z, Gijsbers R, de Rijck J. Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of pogZ Journal of Biological Chemistry. 284: 11467-11477. PMID 19244240 DOI: 10.1074/Jbc.M807781200 |
0.409 |
|
| 2009 |
Ferro S, De Luca L, Barreca ML, Iraci N, De Grazia S, Christ F, Witvrouw M, Debyser Z, Chimirri A. Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions Journal of Medicinal Chemistry. 52: 569-573. PMID 19105658 DOI: 10.1021/Jm8009266 |
0.395 |
|
| 2009 |
Busschots K, De Rijck J, Christ F, Debyser Z. In search of small molecules blocking interactions between HIV proteins and intracellular cofactors Molecular Biosystems. 5: 21-31. PMID 19081927 DOI: 10.1039/B810306B |
0.39 |
|
| 2009 |
Ferro S, De Grazia S, De Luca L, Barreca ML, Debyser Z, Chimirri A. Structural modification of diketo acid portion in 1H-benzylindole derivatives HIV-1 integrase inhibitors Heterocycles. 78: 947-959. DOI: 10.3987/Com-08-11573 |
0.443 |
|
| 2009 |
Thys W, Busschots K, McNeely M, Voet A, Christ F, Debyser Z. LEDGF/p75 and transportin-SR2 are cellular cofactors of HIV integrase and novel targets for antiviral therapy Hiv Therapy. 3: 171-188. DOI: 10.2217/17584310.3.2.171 |
0.514 |
|
| 2008 |
Mcneely M, Christ F, Thys W, Debyser Z. Targeting the HIV integration process in antiviral therapy Journal of Hiv Therapy. 13: 83-92. PMID 19418658 |
0.329 |
|
| 2008 |
Billamboz M, Bailly F, Barreca ML, De Luca L, Mouscadet JF, Calmels C, Andréola ML, Witvrouw M, Christ F, Debyser Z, Cotelle P. Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain Journal of Medicinal Chemistry. 51: 7717-7730. PMID 19053754 DOI: 10.1021/Jm8007085 |
0.383 |
|
| 2008 |
Greene WC, Debyser Z, Ikeda Y, Freed EO, Stephens E, Yonemoto W, Buckheit RW, Esté JA, Cihlar T. Novel targets for HIV therapy. Antiviral Research. 80: 251-65. PMID 18789977 DOI: 10.1016/J.Antiviral.2008.08.003 |
0.49 |
|
| 2008 |
Christ F, Thys W, De Rijck J, Gijsbers R, Albanese A, Arosio D, Emiliani S, Rain JC, Benarous R, Cereseto A, Debyser Z. Transportin-SR2 Imports HIV into the Nucleus Current Biology. 18: 1192-1202. PMID 18722123 DOI: 10.1016/J.Cub.2008.07.079 |
0.495 |
|
| 2008 |
Queffélec C, Bailly F, Mbemba G, Mouscadet JF, Hayes S, Debyser Z, Witvrouw M, Cotelle P. Synthesis and antiviral properties of some polyphenols related to Salvia genus Bioorganic and Medicinal Chemistry Letters. 18: 4736-4740. PMID 18674899 DOI: 10.1016/J.Bmcl.2008.06.063 |
0.347 |
|
| 2008 |
Pasquini S, Mugnaini C, Tintori C, Botta M, Trejos A, Arvela RK, Larhed M, Witvrouw M, Michiels M, Christ F, Debyser Z, Corelli F. Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors Journal of Medicinal Chemistry. 51: 5125-5129. PMID 18665580 DOI: 10.1021/Jm8003784 |
0.407 |
|
| 2008 |
Hombrouck A, Van Remoortel B, Michiels M, Noppe W, Christ F, Eneroth A, Sahlberg BL, Benkestock K, Vrang L, Johansson NG, Barreca ML, De Luca L, Ferro S, Chimirri A, Debyser Z, et al. Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors Antimicrobial Agents and Chemotherapy. 52: 2861-2869. PMID 18541726 DOI: 10.1128/Aac.00210-08 |
0.503 |
|
| 2008 |
Al-Mawsawi LQ, Hombrouck A, Dayam R, Debyser Z, Neamati N. Four-tiered π interaction at the dimeric interface of HIV-1 integrase critical for DNA integration and viral infectivity Virology. 377: 355-363. PMID 18514248 DOI: 10.1016/J.Virol.2008.04.030 |
0.424 |
|
| 2008 |
De Luca L, Barreca ML, Ferro S, Iraci N, Michiels M, Christ F, Debyser Z, Witvrouw M, Chimirri A. A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series Bioorganic and Medicinal Chemistry Letters. 18: 2891-2895. PMID 18417342 DOI: 10.1016/J.Bmcl.2008.03.089 |
0.439 |
|
| 2008 |
Dubois M, Bailly F, Mbemba G, Mouscadet JF, Debyser Z, Witvrouw M, Cotelle P. Reaction of rosmarinic acid with nitrite ions in acidic conditions: Discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents Journal of Medicinal Chemistry. 51: 2575-2579. PMID 18351727 DOI: 10.1021/Jm7011134 |
0.365 |
|
| 2008 |
Al-Mawsawi LQ, Christ F, Dayam R, Debyser Z, Neamati N. Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: Insight into integrase-DNA complex formation and catalysis Febs Letters. 582: 1425-1430. PMID 18331842 DOI: 10.1016/J.Febslet.2008.02.076 |
0.322 |
|
| 2008 |
Dayam R, Al-Mawsawi LQ, Zawahir Z, Witvrouw M, Debyser Z, Neamati N. Quinolone 3-carboxylic acid pharmacophore: Design of second generation HIV-1 integrase inhibitors Journal of Medicinal Chemistry. 51: 1136-1144. PMID 18281931 DOI: 10.1021/Jm070609B |
0.438 |
|
| 2008 |
Queffélec C, Bailly F, Mbemba G, Mouscadet JF, Debyser Z, Witvrouw M, Cotelle P. The total synthesis of fukiic acid, an HIV-1 integrase inhibitor European Journal of Medicinal Chemistry. 43: 2268-2271. PMID 18243421 DOI: 10.1016/J.Ejmech.2007.12.013 |
0.434 |
|
| 2008 |
Selvam P, Murugesh N, Chandramohan M, Debyser Z, Witvrouw M. Design, synthesis and antiHIV activity of novel isatine-sulphonamides Indian Journal of Pharmaceutical Sciences. 70: 779-782. DOI: 10.4103/0250-474X.49121 |
0.465 |
|
| 2008 |
Debyser Z. LEDGF/P75 as a Co-factor of HIV-1 Integrase and as a New Antiviral Target Antiviral Research. 78: A18. DOI: 10.1016/J.Antiviral.2008.01.016 |
0.457 |
|
| 2007 |
Al-Mawsawi LQ, Dayam R, Taheri L, Witvrouw M, Debyser Z, Neamati N. Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors Bioorganic and Medicinal Chemistry Letters. 17: 6472-6475. PMID 17950601 DOI: 10.1016/J.Bmcl.2007.09.102 |
0.42 |
|
| 2007 |
Mugnaini C, Rajamaki S, Tintori C, Corelli F, Massa S, Witvrouw M, Debyser Z, Veljkovic V, Botta M. Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies. Bioorganic & Medicinal Chemistry Letters. 17: 5370-3. PMID 17716893 DOI: 10.1016/J.Bmcl.2007.08.005 |
0.367 |
|
| 2007 |
Bartholomeeusen K, De Rijck J, Busschots K, Desender L, Gijsbers R, Emiliani S, Benarous R, Debyser Z, Christ F. Differential Interaction of HIV-1 Integrase and JPO2 with the C Terminus of LEDGF/p75 Journal of Molecular Biology. 372: 407-421. PMID 17669426 DOI: 10.1016/J.Jmb.2007.06.090 |
0.482 |
|
| 2007 |
Tintori C, Manetti F, Veljkovic N, Perovic V, Vercammen J, Hayes S, Massa S, Witvrouw M, Debyser Z, Veljkovic V, Botta M. Novel virtual screening protocol based on the combined use of molecular modeling and electron-ion interaction potential techniques to design HIV-1 integrase inhibitors. Journal of Chemical Information and Modeling. 47: 1536-44. PMID 17608406 DOI: 10.1021/Ci700078N |
0.397 |
|
| 2007 |
Ferro S, Barreca ML, De Luca L, Rao A, Monforte AM, Debyser Z, Witvrouw M, Chimirri A. New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, β-diketo acid analogs as HIV-1 integrase inhibitors Archiv Der Pharmazie. 340: 292-298. PMID 17562561 DOI: 10.1002/Ardp.200700066 |
0.421 |
|
| 2007 |
Hombrouck A, Hantson A, van Remoortel B, Michiels M, Vercammen J, Rhodes D, Tetz V, Engelborghs Y, Christ F, Debyser Z, Witvrouw M. Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action. The Journal of Antimicrobial Chemotherapy. 59: 1084-95. PMID 17470918 DOI: 10.1093/Jac/Dkm101 |
0.429 |
|
| 2007 |
Chitneni SK, Deroose CM, Fonge H, Gijsbers R, Dyubankova N, Balzarini J, Debyser Z, Mortelmans L, Verbruggen AM, Bormans GM. Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging. Bioorganic & Medicinal Chemistry Letters. 17: 3458-62. PMID 17446073 DOI: 10.1016/J.Bmcl.2007.03.081 |
0.313 |
|
| 2007 |
Hombrouck A, De Rijck J, Hendrix J, Vandekerckhove L, Voet A, De Maeyer M, Witvrouw M, Engelborghs Y, Christ F, Gijsbers R, Debyser Z. Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV Plos Pathogens. 3. PMID 17397262 DOI: 10.1371/Journal.Ppat.0030047 |
0.48 |
|
| 2007 |
Taymans JM, Vandenberghe LH, Haute CV, Thiry I, Deroose CM, Mortelmans L, Wilson JM, Debyser Z, Baekelandt V. Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain. Human Gene Therapy. 18: 195-206. PMID 17343566 DOI: 10.1089/Hum.2006.178 |
0.636 |
|
| 2007 |
Veljkovic V, Mouscadet JF, Veljkovic N, Glisic S, Debyser Z. Simple criterion for selection of flavonoid compounds with anti-HIV activity Bioorganic and Medicinal Chemistry Letters. 17: 1226-1232. PMID 17189684 DOI: 10.1016/J.Bmcl.2006.12.029 |
0.425 |
|
| 2007 |
Busschots K, Voet A, De Maeyer M, Rain JC, Emiliani S, Benarous R, Desender L, Debyser Z, Christ F. Identification of the LEDGF/p75 Binding Site in HIV-1 Integrase Journal of Molecular Biology. 365: 1480-1492. PMID 17137594 DOI: 10.1016/J.Jmb.2006.10.094 |
0.434 |
|
| 2007 |
SELVAM P, MURUGESH N, CHANDRAMOHAN M, DEBYSER Z, WITVROUW M, ENGELBORGHS Y. Design, Synthesis and Anti-HIV Activity of Some Novel Isatin Derivatives Antiviral Research. 74: A68-A68. DOI: 10.1016/J.Antiviral.2007.01.107 |
0.43 |
|
| 2006 |
De Rijck J, Vandekerckhove L, Gijsbers R, Hombrouck A, Hendrix J, Vercammen J, Engelborghs Y, Christ F, Debyser Z. Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication Journal of Virology. 80: 11498-11509. PMID 16987986 DOI: 10.1128/Jvi.00801-06 |
0.517 |
|
| 2006 |
De Rijck J, Debyser Z. The central DNA flap of the human immunodeficiency virus type 1 is important for viral replication Biochemical and Biophysical Research Communications. 349: 1100-1110. PMID 16962998 DOI: 10.1016/J.Bbrc.2006.08.141 |
0.391 |
|
| 2006 |
Deroose CM, Reumers V, Gijsbers R, Bormans G, Debyser Z, Mortelmans L, Baekelandt V. Noninvasive monitoring of long-term lentiviral vector-mediated gene expression in rodent brain with bioluminescence imaging. Molecular Therapy : the Journal of the American Society of Gene Therapy. 14: 423-31. PMID 16820324 DOI: 10.1016/J.Ymthe.2006.05.007 |
0.304 |
|
| 2006 |
Geraerts M, Eggermont K, Hernandez-Acosta P, Garcia-Verdugo JM, Baekelandt V, Debyser Z. Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo Human Gene Therapy. 17: 635-650. PMID 16776572 DOI: 10.1089/Hum.2006.17.635 |
0.309 |
|
| 2006 |
Vandekerckhove L, Christ F, Van Maele B, De Rijck J, Gijsbers R, Van Den Haute C, Witvrouw M, Debyser Z. Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus Journal of Virology. 80: 1886-1896. PMID 16439544 DOI: 10.1128/Jvi.80.4.1886-1896.2006 |
0.508 |
|
| 2006 |
Van Maele B, Busschots K, Vandekerckhove L, Christ F, Debyser Z. Cellular co-factors of HIV-1 integration Trends in Biochemical Sciences. 31: 98-105. PMID 16403635 DOI: 10.1016/J.Tibs.2005.12.002 |
0.502 |
|
| 2006 |
Adams MM, Bats JW, Nikolaus NV, Witvrouw M, Debyser Z, Engels JW. Microwave-assisted synthesis of fluoroquinolones and their nucleosides as inhibitors of HIV integrase Collection of Czechoslovak Chemical Communications. 71: 978-990. DOI: 10.1135/Cccc20060978 |
0.412 |
|
| 2006 |
Vandekerckhove L, De Rijck J, Christ F, Gijsbers R, Debyser Z. RNAi-based treatment of HIV/AIDS: Current status and perspectives Drug Discovery Today: Therapeutic Strategies. 3: 227-235. DOI: 10.1016/J.Ddstr.2006.06.013 |
0.471 |
|
| 2006 |
Toelen J, Sbragia L, Gijsbers R, Sara D, Roubliova X, Debyser Z, Deprest J. Transduction of human pulmonary epithelial cell lines with a lentiviral vector American Journal of Obstetrics and Gynecology. 195: S179. DOI: 10.1016/J.Ajog.2006.10.640 |
0.319 |
|
| 2005 |
Barreca ML, Ferro S, Rao A, De Luca L, Zappalà M, Monforte AM, Debyser Z, Witvrouw M, Chimirri A. Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors Journal of Medicinal Chemistry. 48: 7084-7088. PMID 16250669 DOI: 10.1021/Jm050549E |
0.385 |
|
| 2005 |
Hantson A, Fikkert V, Van Remoortel B, Pannecouque C, Cherepanov P, Matthews B, Holan G, De Clercq E, Vandamme AM, Debyser Z, Witvrouw M. Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology Antiviral Chemistry and Chemotherapy. 16: 253-266. PMID 16130523 DOI: 10.1177/095632020501600405 |
0.349 |
|
| 2005 |
Geraerts M, Micheils M, Baekelandt V, Debyser Z, Gijsbers R. Upscaling of lentiviral vector production by tangential flow filtration Journal of Gene Medicine. 7: 1299-1310. PMID 15906396 DOI: 10.1002/Jgm.778 |
0.395 |
|
| 2005 |
van Griensven J, De Clercq E, Debyser Z. Hematopoietic stem cell-based gene therapy against HIV infection: Promises and caveats Aids Reviews. 7: 44-55. PMID 15875660 |
0.35 |
|
| 2005 |
Van Maele B, Debyser Z. HIV-1 integration: An interplay between HIV-1 integrase, cellular and viral proteins Aids Reviews. 7: 26-43. PMID 15875659 |
0.365 |
|
| 2005 |
Emiliani S, Mousnier A, Busschots K, Maroun M, Van Maele B, Tempé D, Vandekerckhove L, Moisant F, Ben-Slama L, Witvrouw M, Christ F, Rain JC, Dargemont C, Debyser Z, Benarous R. Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication Journal of Biological Chemistry. 280: 25517-25523. PMID 15855167 DOI: 10.1074/Jbc.M501378200 |
0.489 |
|
| 2005 |
Maertens G, Vercammen J, Debyser Z, Engelborghs Y. Measuring protein-protein interactions inside living cells using single color fluorescence correlation spectroscopy. Application to human immunodeficiency virus type 1 integrase and LEDGF/p75 Faseb Journal. 19: 1039-1041. PMID 15788449 DOI: 10.1096/Fj.04-3373Fje |
0.403 |
|
| 2005 |
Busschots K, Vercammen J, Emiliani S, Benarous R, Engelborghs Y, Christ F, Debyser Z. The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding Journal of Biological Chemistry. 280: 17841-17847. PMID 15749713 DOI: 10.1074/Jbc.M411681200 |
0.476 |
|
| 2005 |
De Rijck J, Van Maele B, Debyser Z. Positional effects of the central DNA flap in HIV-1-derived lentiviral vectors Biochemical and Biophysical Research Communications. 328: 987-994. PMID 15707975 DOI: 10.1016/J.Bbrc.2005.01.052 |
0.44 |
|
| 2005 |
Van Maele B, Van Eylen L, Pluymers W, Debyser Z. Evaluation of the activity of HIV-1 integrase over-expressed in eukaryotic cells Biochemical and Biophysical Research Communications. 327: 261-267. PMID 15629457 DOI: 10.1016/J.Bbrc.2004.11.157 |
0.474 |
|
| 2005 |
Fikkert V, Hombrouck A, Van Remoortel B, De Maeyer M, Pannecouque C, De Clercq E, Debyser Z, Witvrouw M. Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360. Aids (London, England). 18: 2019-28. PMID 15577623 DOI: 10.1097/00002030-200410210-00006 |
0.433 |
|
| 2005 |
Witvrouw M, Van Maele B, Vercammen J, Hantson A, Engelborghs Y, De Clercq E, Pannecouque C, Debyser Z. Novel inhibitors of HIV-1 integration. Current Drug Metabolism. 5: 291-304. PMID 15320701 DOI: 10.2174/1389200043335487 |
0.484 |
|
| 2005 |
Ferro S, Rao A, Zappala M, Chimirri A, Barreca ML, Witvrouw M, Debyser Z, Monforte P. Synthesis of New Potential HIV-1 Integrase Inhibitors. Cheminform. 36. DOI: 10.3987/Com-04-10193 |
0.445 |
|
| 2005 |
Witvrouw M, Fikkert V, Vercammen J, Van Maele B, Engelborghs Y, Debyser Z. Identification of authentic inhibitors of HIV-1 integration Current Medicinal Chemistry: Anti-Infective Agents. 4: 153-165. DOI: 10.2174/1568012053507007 |
0.508 |
|
| 2004 |
Barreca ML, Rao A, De Luca L, Zappalà M, Gurnari C, Monforte P, De Clercq E, Van Maele B, Debyser Z, Witvrouw M, Briggs JM, Chimirri A. Efficient 3D database screening for novel HIV-1 IN inhibitors. Journal of Chemical Information and Computer Sciences. 44: 1450-5. PMID 15272853 DOI: 10.1021/Ci034296E |
0.433 |
|
| 2004 |
Maertens G, Cherepanov P, Debyser Z, Engelborghs Y, Engelman A. Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75. The Journal of Biological Chemistry. 279: 33421-9. PMID 15163664 DOI: 10.1074/Jbc.M404700200 |
0.41 |
|
| 2004 |
van Griensven J, Zhan X, Van Maele B, Pluymers W, Michiels M, De Clercq E, Cherepanov P, Debyser Z. Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication. The Journal of Gene Medicine. 6: 268-77. PMID 15026988 DOI: 10.1002/Jgm.520 |
0.494 |
|
| 2004 |
Debyser Z. Biosafety of lentiviral vectors. Current Gene Therapy. 3: 517-25. PMID 14683448 DOI: 10.2174/1566523034578177 |
0.379 |
|
| 2004 |
Monforte P, Ferro S, Rao A, Zappalà M, Chimirri A, Letizia Barreca M, Witvrouw M, Debyser Z. Synthesis of New Potential HIV-1 Integrase Inhibitors Heterocycles. 63: 2727. DOI: 10.3987/com-04-10193 |
0.344 |
|
| 2003 |
Van den Haute C, Eggermont K, Nuttin B, Debyser Z, Baekelandt V. Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain. Human Gene Therapy. 14: 1799-807. PMID 14670130 DOI: 10.1089/104303403322611809 |
0.347 |
|
| 2003 |
Fikkert V, Van Maele B, Vercammen J, Hantson A, Van Remoortel B, Michiels M, Gurnari C, Pannecouque C, De Maeyer M, Engelborghs Y, De Clercq E, Debyser Z, Witvrouw M. Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations. Journal of Virology. 77: 11459-70. PMID 14557631 DOI: 10.1128/Jvi.77.21.11459-11470.2003 |
0.388 |
|
| 2003 |
Baekelandt V, Eggermont K, Michiels M, Nuttin B, Debyser Z. Optimized lentiviral vector production and purification procedure prevents immune response after transduction of mouse brain. Gene Therapy. 10: 1933-40. PMID 14528317 DOI: 10.1038/Sj.Gt.3302094 |
0.332 |
|
| 2003 |
Maertens G, Cherepanov P, Pluymers W, Busschots K, De Clercq E, Debyser Z, Engelborghs Y. LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. The Journal of Biological Chemistry. 278: 33528-39. PMID 12796494 DOI: 10.1074/Jbc.M303594200 |
0.396 |
|
| 2003 |
Lagoja IM, Pannecouque C, Van Aerschot A, Witvrouw M, Debyser Z, Balzarini J, Herdewijn P, De Clercq E. N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action. Journal of Medicinal Chemistry. 46: 1546-53. PMID 12672256 DOI: 10.1021/Jm0211117 |
0.418 |
|
| 2003 |
Van Maele B, De Rijck J, De Clercq E, Debyser Z. Impact of the central polypurine tract on the kinetics of human immunodeficiency virus type 1 vector transduction. Journal of Virology. 77: 4685-94. PMID 12663775 DOI: 10.1128/Jvi.77.8.4685-4694.2003 |
0.482 |
|
| 2003 |
Okamoto M, Wang X, Debyser Z, De Clercq E, Baba M. Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof. Journal of Virological Methods. 108: 195-203. PMID 12609687 DOI: 10.1016/S0166-0934(02)00288-4 |
0.421 |
|
| 2003 |
Cherepanov P, Maertens G, Proost P, Devreese B, Van Beeumen J, Engelborghs Y, De Clercq E, Debyser Z. HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells. The Journal of Biological Chemistry. 278: 372-81. PMID 12407101 DOI: 10.1074/Jbc.M209278200 |
0.48 |
|
| 2002 |
Pluymers W, De Clercq E, Debyser Z. HIV-1 integration as a target for antiretroviral therapy: a review. Current Drug Targets. Infectious Disorders. 1: 133-49. PMID 12455410 DOI: 10.2174/1568005014606044 |
0.492 |
|
| 2002 |
Fikkert V, Cherepanov P, Van Laethem K, Hantson A, Van Remoortel B, Pannecouque C, De Clercq E, Debyser Z, Vandamme AM, Witvrouw M. env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors. Antimicrobial Agents and Chemotherapy. 46: 3954-62. PMID 12435701 DOI: 10.1128/Aac.46.12.3954-3962.2002 |
0.402 |
|
| 2002 |
Pluymers W, Pais G, Van Maele B, Pannecouque C, Fikkert V, Burke TR, De Clercq E, Witvrouw M, Neamati N, Debyser Z. Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives. Antimicrobial Agents and Chemotherapy. 46: 3292-7. PMID 12234864 DOI: 10.1128/Aac.46.10.3292-3297.2002 |
0.481 |
|
| 2002 |
Debyser Z, Cherepanov P, Van Maele B, De Clercq E, Witvrouw M. In search of authentic inhibitors of HIV-1 integration. Antiviral Chemistry & Chemotherapy. 13: 1-15. PMID 12180645 DOI: 10.1177/095632020201300101 |
0.502 |
|
| 2002 |
Pannecouque C, Pluymers W, Van Maele B, Tetz V, Cherepanov P, De Clercq E, Witvrouw M, Debyser Z. New class of HIV integrase inhibitors that block viral replication in cell culture. Current Biology : Cb. 12: 1169-77. PMID 12176326 DOI: 10.1016/S0960-9822(02)00952-1 |
0.489 |
|
| 2002 |
Vercammen J, Maertens G, Gerard M, De Clercq E, Debyser Z, Engelborghs Y. DNA-induced polymerization of HIV-1 integrase analyzed with fluorescence fluctuation spectroscopy. The Journal of Biological Chemistry. 277: 38045-52. PMID 12147698 DOI: 10.1074/Jbc.M205842200 |
0.34 |
|
| 2002 |
Baekelandt V, Claeys A, Eggermont K, Lauwers E, De Strooper B, Nuttin B, Debyser Z. Characterization of lentiviral vector-mediated gene transfer in adult mouse brain. Human Gene Therapy. 13: 841-53. PMID 11975850 DOI: 10.1089/10430340252899019 |
0.359 |
|
| 2001 |
Debyser Z, Cherepanov P, Pluymers W, De Clercq E. Assays for the evaluation of HIV-1 integrase inhibitors Methods in Molecular Biology (Clifton, N.J.). 160: 139-155. PMID 11265279 DOI: 10.1385/1-59259-233-3:139 |
0.454 |
|
| 2000 |
Baekelandt V, Claeys A, Cherepanov P, De Clercq E, De Strooper B, Nuttin B, Debyser Z. DNA-Dependent protein kinase is not required for efficient lentivirus integration. Journal of Virology. 74: 11278-85. PMID 11070027 DOI: 10.1128/Jvi.74.23.11278-11285.2000 |
0.375 |
|
| 2000 |
Pluymers W, Neamati N, Pannecouque C, Fikkert V, Marchand C, Burke TR, Pommier Y, Schols D, De Clercq E, Debyser Z, Witvrouw M. Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters. Molecular Pharmacology. 58: 641-8. PMID 10953059 DOI: 10.1124/Mol.58.3.641 |
0.345 |
|
| 2000 |
Cherepanov P, Pluymers W, Claeys A, Proost P, De Clercq E, Debyser Z. High-level expression of active HIV-1 integrase from a synthetic gene in human cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 1389-99. PMID 10877832 DOI: 10.1096/Fj.14.10.1389 |
0.465 |
|
| 2000 |
Witvrouw M, Fikkert V, Pluymers W, Matthews B, Mardel K, Schols D, Raff J, Debyser Z, De Clercq E, Holan G, Pannecouque C. Polyanionic (i.e., Polysulfonate) Dendrimers Can Inhibit the Replication of Human Immunodeficiency Virus by Interfering with Both Virus Adsorption and Later Steps (Reverse Transcriptase/Integrase) in the Virus Replicative Cycle Molecular Pharmacology. 58: 1100-1108. DOI: 10.1124/Mol.58.5.1100 |
0.445 |
|
| 2000 |
Pannecouque C, Pluymers W, Fikkert V, Neamati N, Marchand C, Burke T, Pommier Y, De Clercq E, Debyser Z, Witvrouw M. 4 Viral entry as the primary target of anti-HIV activity of chicoric acid and its tetra-acetyl esters Antiviral Research. 46: A36. DOI: 10.1016/S0166-3542(00)90335-8 |
0.44 |
|
| 1999 |
Pluymers W, Cherepanov P, Schols D, De Clercq E, Debyser Z. Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein. Virology. 258: 327-32. PMID 10366569 DOI: 10.1006/Viro.1999.9727 |
0.465 |
|
| 1999 |
Oelrichs RB, Vandamme AM, Van Laethem K, Debyser Z, McCutchan FE, Deacon NJ. Full-length genomic sequence of an HIV type 1 subtype G from Kinshasa. Aids Research and Human Retroviruses. 15: 585-9. PMID 10221535 DOI: 10.1089/088922299311105 |
0.372 |
|
| 1999 |
Cherepanov P, Surratt D, Toelen J, Pluymers W, Griffith J, De Clercq E, Debyser Z. Activity of recombinant HIV-1 integrase on mini-HIV DNA. Nucleic Acids Research. 27: 2202-10. PMID 10219094 DOI: 10.1093/Nar/27.10.2202 |
0.466 |
|
| 1999 |
Lin Z, Neamati N, Zhao H, Kiryu Y, Turpin JA, Aberham C, Strebel K, Kohn K, Witvrouw M, Pannecouque C, Debyser Z, De Clercq E, Rice WG, Pommier Y, Burke TR. Chicoric acid analogues as HIV-1 integrase inhibitors. Journal of Medicinal Chemistry. 42: 1401-14. PMID 10212126 DOI: 10.1021/Jm980531M |
0.453 |
|
| 1998 |
Debyser Z, Van Wijngaerden E, Van Laethem K, Beuselinck K, Reynders M, De Clercq E, Desmyter J, Vandamme AM. Failure to quantify viral load with two of the three commercial methods in a pregnant woman harboring an HIV type 1 subtype G strain. Aids Research and Human Retroviruses. 14: 453-9. PMID 9546805 DOI: 10.1089/Aid.1998.14.453 |
0.444 |
|
| 1998 |
Esté JA, Cabrera C, Schols D, Cherepanov P, Gutierrez A, Witvrouw M, Pannecouque C, Debyser Z, Rando RF, Clotet B, Desmyter J, De Clercq E. Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir). Molecular Pharmacology. 53: 340-5. PMID 9463493 DOI: 10.1124/Mol.53.2.340 |
0.462 |
|
| 1997 |
Cherepanov P, Esté JA, Rando RF, Ojwang JO, Reekmans G, Steinfeld R, David G, De Clercq E, Debyser Z. Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1. Molecular Pharmacology. 52: 771-80. PMID 9351967 DOI: 10.1124/Mol.52.5.771 |
0.455 |
|
| 1997 |
Witvrouw M, Balzarini J, Pannecouque C, Jhaumeer-Laulloo S, Esté JA, Schols D, Cherepanov P, Schmit JC, Debyser Z, Vandamme AM, Desmyter J, Ramadas SR, de Clercq E. SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus. Antimicrobial Agents and Chemotherapy. 41: 262-8. PMID 9021177 DOI: 10.1128/Aac.41.2.262 |
0.475 |
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| 1997 |
Jonckheere H, De Vreese K, Debyser Z, Vandekerckhove J, Balzarini J, Desmyter J, De Clercq E, Anné J. A two plasmid co-expression system in Escherichia coli for the production of virion-like reverse transcriptase of the human immunodeficiency virus type 1. Journal of Virological Methods. 61: 113-25. PMID 8882944 DOI: 10.1016/0166-0934(96)02076-9 |
0.428 |
|
| 1997 |
Witvrouw M, Balzarini J, Pannecouque C, Jhaumeer-Laulloo S, Esté JA, Schols D, Cherepanov P, Schmit JC, Debyser Z, Vandamme AM, Desmyter J, Ramadas SR, de Clercq E. SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus. Antimicrobial Agents and Chemotherapy. 41: 262-268. DOI: 10.1128/aac.41.2.262 |
0.373 |
|
| 1997 |
Este J, Schols D, Witvrouw M, Cherepanov P, Pannecouque C, Rando R, Debyser Z, Desmyter J, De Clercq E. Human immunodeficiency virus gp120 as the primary target of action of AR177 (Zintevir) Antiviral Research. 34: A57. DOI: 10.1016/S0166-3542(97)83191-9 |
0.309 |
|
| 1997 |
Witvrouw M, Pannecouque C, Balzarini J, Jhaumeer-Laulloo S, Pluymers W, Este J, Schols D, Cherepanov P, Schmit J, Debyser Z, Vandamme A, Desmyter J, Ramadas S, De Clercq E. Disulfide-containing macrolides that inhibit a late stage of the replicative cycle of human immunodeficiency virus Antiviral Research. 34: A48. DOI: 10.1016/S0166-3542(97)83162-2 |
0.318 |
|
| 1996 |
Debyser Z, De Clercq E. Chemical crosslinking of the subunits of HIV-1 reverse transcriptase. Protein Science : a Publication of the Protein Society. 5: 278-86. PMID 8745406 DOI: 10.1002/Pro.5560050212 |
0.447 |
|
| 1995 |
Pauwels R, Andries K, Debyser Z, Kukla MJ, Schols D, Breslin HJ, Woestenborghs R, Desmyter J, Janssen MA, De Clercq E. New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs. Antimicrobial Agents and Chemotherapy. 38: 2863-70. PMID 7535037 DOI: 10.1128/Aac.38.12.2863 |
0.49 |
|
| 1995 |
Thormar H, Balzarini J, Debyser Z, Witvrouw M, Desmyter J, De Clercq E. Inhibition of visna virus replication and cytopathic effect in sheep choroid plexus cell cultures by selected anti-HIV agents. Antiviral Research. 27: 49-57. PMID 7486958 DOI: 10.1016/0166-3542(94)00082-J |
0.458 |
|
| 1994 |
De Clercq E, Yamamoto N, Pauwels R, Balzarini J, Witvrouw M, De Vreese K, Debyser Z, Rosenwirth B, Peichl P, Datema R. Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100. Antimicrobial Agents and Chemotherapy. 38: 668-74. PMID 7913308 DOI: 10.1128/Aac.38.4.668 |
0.486 |
|
| 1994 |
Vandamme AM, Debyser Z, Pauwels R, De Vreese K, Goubau P, Youle M, Gazzard B, Stoffels PA, Cauwenbergh GF, Anne J. Characterization of HIV-1 strains isolated from patients treated with TIBO R82913. Aids Research and Human Retroviruses. 10: 39-46. PMID 7514016 DOI: 10.1089/Aid.1994.10.39 |
0.402 |
|
| 1994 |
Debyser Z, Pauwels R, Andries K, De Clercq E. Specific HIV-1 reverse transcriptase inhibitors. Journal of Enzyme Inhibition. 6: 47-53. PMID 1285302 DOI: 10.3109/14756369209041355 |
0.462 |
|
| 1993 |
Pauwels R, Andries K, Debyser Z, Van Daele P, Schols D, Stoffels P, De Vreese K, Woestenborghs R, Vandamme AM, Janssen CG. Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase. Proceedings of the National Academy of Sciences of the United States of America. 90: 1711-5. PMID 7680476 DOI: 10.1073/Pnas.90.5.1711 |
0.477 |
|
| 1992 |
De Clercq E, Yamamoto N, Pauwels R, Baba M, Schols D, Nakashima H, Balzarini J, Debyser Z, Murrer BA, Schwartz D. Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event. Proceedings of the National Academy of Sciences of the United States of America. 89: 5286-90. PMID 1608936 DOI: 10.1073/Pnas.89.12.5286 |
0.497 |
|
| 1992 |
Pauwels R, Andries K, Debyser Z, Kukla M, Schols D, Desmyter J, De Clercq E, Janssen PA. TIBO derivatives: a new class of highly potent and specific inhibitors of HIV-1 replication. Biochemical Society Transactions. 20: 509-12. PMID 1383063 DOI: 10.1042/Bst0200509 |
0.467 |
|
| 1992 |
Debyser Z, De Vreese K, Pauwels R, Yamamoto N, Anné J, De Clercq E, Desmyter J. Differential inhibitory effects of TIBO derivatives on different strains of simian immunodeficiency virus. The Journal of General Virology. 1799-804. PMID 1378481 DOI: 10.1099/0022-1317-73-7-1799 |
0.474 |
|
| 1992 |
de Vreese K, Debyser Z, Vandamme AM, Pauwels R, Desmyter J, de Clercq E, Anné J. Resistance of human immunodeficiency virus type 1 reverse transcriptase to TIBO derivatives induced by site-directed mutagenesis. Virology. 188: 900-4. PMID 1374986 DOI: 10.1016/0042-6822(92)90550-9 |
0.47 |
|
| 1991 |
Debyser Z, Pauwels R, Andries K, Desmyter J, Kukla M, Janssen PA, De Clercq E. An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives. Proceedings of the National Academy of Sciences of the United States of America. 88: 1451-5. PMID 1705038 DOI: 10.1073/Pnas.88.4.1451 |
0.494 |
|
| 1991 |
Pauwels R, Debyser Z, Andries K, Baba M, Schols D, Kukla M, Desmyter J, Janssen P, De Clercq E. The TIBO-site on HIV-1 reverse transcriptase represents a new target for anti-HIV chemotherapy Antiviral Research. 15: 85. DOI: 10.1016/0166-3542(91)90164-M |
0.459 |
|
| 1989 |
Pauwels R, Debyser Z, Balzarini J, Baba M, Desmyter J, Rayner B, Morvan F, Imbach JL, De Clercq E. Alpba-Oligodeoxynucleotides as Inhibitors of HIV Reverse Transcriptase Nucleosides, Nucleotides and Nucleic Acids. 8: 995-1000. DOI: 10.1080/07328318908054262 |
0.352 |
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