Year |
Citation |
Score |
2024 |
Sun J, Kessl JJ. Optimizing the Multimerization Properties of Quinoline-Based Allosteric HIV-1 Integrase Inhibitors. Viruses. 16. PMID 38399977 DOI: 10.3390/v16020200 |
0.642 |
|
2022 |
Dinh LP, Sun J, Glenn CD, Patel K, Pigza JA, Donahue MG, Yet L, Kessl JJ. Multi-Substituted Quinolines as HIV-1 Integrase Allosteric Inhibitors. Viruses. 14. PMID 35891446 DOI: 10.3390/v14071466 |
0.63 |
|
2022 |
Adu-Ampratwum D, Pan Y, Koneru PC, Antwi J, Hoyte AC, Kessl J, Griffin PR, Kvaratskhelia M, Fuchs JR, Larue RC. Identification and Optimization of a Novel HIV-1 Integrase Inhibitor. Acs Omega. 7: 4482-4491. PMID 35155940 DOI: 10.1021/acsomega.1c06378 |
0.611 |
|
2021 |
Sun J, Patel K, Hume J, Pigza JA, Donahue MG, Kessl JJ. Optimized binding of substituted quinoline ALLINIs within the HIV-1 integrase oligomer. The Journal of Biological Chemistry. 100363. PMID 33539919 DOI: 10.1016/j.jbc.2021.100363 |
0.614 |
|
2018 |
Jentsch NG, Hart AP, Hume JD, Sun J, McNeely KA, Lama C, Pigza JA, Donahue MG, Kessl JJ. Synthesis and Evaluation of Aryl Quinolines as HIV-1 Integrase Multimerization Inhibitors. Acs Medicinal Chemistry Letters. 9: 1007-1012. PMID 30344908 DOI: 10.1021/Acsmedchemlett.8B00269 |
0.629 |
|
2018 |
Jentsch NG, Hume JD, Crull EB, Beauti SM, Pham AH, Pigza JA, Kessl JJ, Donahue MG. Quinolines from the cyclocondensation of isatoic anhydride with ethyl acetoacetate: preparation of ethyl 4-hydroxy-2-methylquinoline-3-carboxylate and derivatives. Beilstein Journal of Organic Chemistry. 14: 2529-2536. PMID 30344776 DOI: 10.3762/Bjoc.14.229 |
0.558 |
|
2018 |
Zhao XZ, Métifiot M, Kiselev E, Kessl JJ, Maddali K, Marchand C, Kvaratskhelia M, Pommier Y, Burke TR. HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence. Molecules (Basel, Switzerland). 23. PMID 30049955 DOI: 10.3390/molecules23081858 |
0.418 |
|
2016 |
Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. The Journal of Biological Chemistry. 291: 23569-23577. PMID 27645997 DOI: 10.1074/Jbc.M116.753384 |
0.623 |
|
2016 |
Patel PA, Kvaratskhelia N, Mansour Y, Antwi J, Feng L, Koneru P, Kobe MJ, Jena N, Shi G, Mohamed MS, Li C, Kessl JJ, Fuchs JR. Indole-based allosteric inhibitors of HIV-1 integrase. Bioorganic & Medicinal Chemistry Letters. PMID 27568085 DOI: 10.1016/J.Bmcl.2016.08.037 |
0.552 |
|
2016 |
Kessl JJ, Kutluay SB, Townsend D, Rebensburg S, Slaughter A, Larue RC, Shkriabai N, Bakouche N, Fuchs JR, Bieniasz PD, Kvaratskhelia M. HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis. Cell. 166: 1257-1268.e12. PMID 27565348 DOI: 10.1016/J.Cell.2016.07.044 |
0.356 |
|
2016 |
Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M. The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency. Acs Chemical Biology. 11: 1313-21. PMID 26910179 DOI: 10.1021/Acschembio.6B00167 |
0.56 |
|
2016 |
Kessl JJ, Sharma A, Kvaratskhelia M. Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase. Methods in Molecular Biology (Clifton, N.J.). 1354: 149-64. PMID 26714710 DOI: 10.1007/978-1-4939-3046-3_10 |
0.456 |
|
2015 |
Feng L, Larue RC, Slaughter A, Kessl JJ, Kvaratskhelia M. HIV-1 integrase multimerization as a therapeutic target. Current Topics in Microbiology and Immunology. 389: 93-119. PMID 25778682 DOI: 10.1007/82_2015_439 |
0.541 |
|
2014 |
Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology. 11: 100. PMID 25421939 DOI: 10.1186/S12977-014-0100-1 |
0.571 |
|
2014 |
Shkriabai N, Dharmarajan V, Slaughter A, Kessl JJ, Larue RC, Feng L, Fuchs JR, Griffin PR, Kvaratskhelia M. A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase. The Journal of Biological Chemistry. 289: 26430-40. PMID 25118283 DOI: 10.1074/jbc.M114.589572 |
0.458 |
|
2014 |
Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. A new class of multimerization selective inhibitors of HIV-1 integrase. Plos Pathogens. 10: e1004171. PMID 24874515 DOI: 10.1371/Journal.Ppat.1004171 |
0.624 |
|
2013 |
Sharma A, Larue RC, Plumb MR, Malani N, Male F, Slaughter A, Kessl JJ, Shkriabai N, Coward E, Aiyer SS, Green PL, Wu L, Roth MJ, Bushman FD, Kvaratskhelia M. BET proteins promote efficient murine leukemia virus integration at transcription start sites. Proceedings of the National Academy of Sciences of the United States of America. 110: 12036-41. PMID 23818621 DOI: 10.1073/Pnas.1307157110 |
0.334 |
|
2013 |
Engelman A, Kessl JJ, Kvaratskhelia M. Allosteric inhibition of HIV-1 integrase activity. Current Opinion in Chemical Biology. 17: 339-45. PMID 23647983 DOI: 10.1016/J.Cbpa.2013.04.010 |
0.512 |
|
2013 |
Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M. The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors. The Journal of Biological Chemistry. 288: 15813-20. PMID 23615903 DOI: 10.1074/Jbc.M112.443390 |
0.587 |
|
2013 |
Jurado KA, Wang H, Slaughter A, Feng L, Kessl JJ, Koh Y, Wang W, Ballandras-Colas A, Patel PA, Fuchs JR, Kvaratskhelia M, Engelman A. Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation. Proceedings of the National Academy of Sciences of the United States of America. 110: 8690-5. PMID 23610442 DOI: 10.1073/Pnas.1300703110 |
0.558 |
|
2012 |
Larue R, Gupta K, Wuensch C, Shkriabai N, Kessl JJ, Danhart E, Feng L, Taltynov O, Christ F, Van Duyne GD, Debyser Z, Foster MP, Kvaratskhelia M. Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2). The Journal of Biological Chemistry. 287: 34044-58. PMID 22872640 DOI: 10.1074/Jbc.M112.384669 |
0.524 |
|
2012 |
Kessl JJ, Jena N, Koh Y, Taskent-Sezgin H, Slaughter A, Feng L, de Silva S, Wu L, Le Grice SF, Engelman A, Fuchs JR, Kvaratskhelia M. Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors. The Journal of Biological Chemistry. 287: 16801-11. PMID 22437836 DOI: 10.1074/Jbc.M112.354373 |
0.621 |
|
2011 |
Kessl JJ, Li M, Ignatov M, Shkriabai N, Eidahl JO, Feng L, Musier-Forsyth K, Craigie R, Kvaratskhelia M. FRET analysis reveals distinct conformations of in tetramers in the presence of viral DNA or LEDGF/p75 Nucleic Acids Research. 39: 9009-9022. PMID 21771857 DOI: 10.1093/Nar/Gkr581 |
0.303 |
|
2009 |
Kessl JJ, McKee CJ, Eidahl JO, Shkriabai N, Katz A, Kvaratskhelia M. HIV-1 Integrase-DNA Recognition Mechanisms. Viruses. 1: 713-36. PMID 21994566 DOI: 10.3390/v1030713 |
0.38 |
|
2009 |
Kessl JJ, Eidahl JO, Shkriabai N, Zhao Z, McKee CJ, Hess S, Burke TR, Kvaratskhelia M. An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule. Molecular Pharmacology. 76: 824-32. PMID 19638533 DOI: 10.1124/mol.109.058883 |
0.519 |
|
2008 |
McKee CJ, Kessl JJ, Shkriabai N, Dar MJ, Engelman A, Kvaratskhelia M. Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein. The Journal of Biological Chemistry. 283: 31802-12. PMID 18801737 DOI: 10.1074/Jbc.M805843200 |
0.395 |
|
2008 |
Zhao Z, McKee CJ, Kessl JJ, Santos WL, Daigle JE, Engelman A, Verdine G, Kvaratskhelia M. Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding. The Journal of Biological Chemistry. 283: 5632-41. PMID 18093980 DOI: 10.1074/Jbc.M705241200 |
0.4 |
|
Low-probability matches (unlikely to be authored by this person) |
2007 |
Kessl JJ, Moskalev NV, Gribble GW, Nasr M, Meshnick SR, Trumpower BL. Parameters determining the relative efficacy of hydroxy-naphthoquinone inhibitors of the cytochrome bc1 complex. Biochimica Et Biophysica Acta. 1767: 319-26. PMID 17383607 DOI: 10.1016/J.Bbabio.2007.02.014 |
0.294 |
|
2008 |
McKee CJ, Kessl JJ, Norris JO, Shkriabai N, Kvaratskhelia M. Mass spectrometry-based footprinting of protein-protein interactions. Methods (San Diego, Calif.). 47: 304-7. PMID 19015031 DOI: 10.1016/j.ymeth.2008.10.023 |
0.209 |
|
2003 |
Kessl JJ, Lange BB, Merbitz-Zahradnik T, Zwicker K, Hill P, Meunier B, Pálsdóttir H, Hunte C, Meshnick S, Trumpower BL. Molecular basis for atovaquone binding to the cytochrome bc1 complex. The Journal of Biological Chemistry. 278: 31312-8. PMID 12791689 DOI: 10.1074/Jbc.M304042200 |
0.196 |
|
2004 |
Kessl JJ, Hill P, Lange BB, Meshnick SR, Meunier B, Trumpower BL. Molecular basis for atovaquone resistance in Pneumocystis jirovecii modeled in the cytochrome bc(1) complex of Saccharomyces cerevisiae. The Journal of Biological Chemistry. 279: 2817-24. PMID 14576156 DOI: 10.1074/Jbc.M309984200 |
0.188 |
|
2006 |
Kessl JJ, Ha KH, Merritt AK, Meshnick SR, Trumpower BL. Molecular basis of Toxoplasma gondii atovaquone resistance modeled in Saccharomyces cerevisiae. Molecular and Biochemical Parasitology. 146: 255-8. PMID 16412524 DOI: 10.1016/J.Molbiopara.2005.12.002 |
0.179 |
|
2007 |
Kessl JJ, Meshnick SR, Trumpower BL. Modeling the molecular basis of atovaquone resistance in parasites and pathogenic fungi. Trends in Parasitology. 23: 494-501. PMID 17826334 DOI: 10.1016/J.Pt.2007.08.004 |
0.14 |
|
2005 |
Kessl JJ, Ha KH, Merritt AK, Lange BB, Hill P, Meunier B, Meshnick SR, Trumpower BL. Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 280: 17142-8. PMID 15718226 DOI: 10.1074/Jbc.M500388200 |
0.135 |
|
2003 |
Hill P, Kessl J, Fisher N, Meshnick S, Trumpower BL, Meunier B. Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis jiroveci. Antimicrobial Agents and Chemotherapy. 47: 2725-31. PMID 12936966 DOI: 10.1128/Aac.47.9.2725-2731.2003 |
0.106 |
|
2024 |
Somarathne RP, Misra SK, Kariyawasam CS, Kessl JJ, Sharp JS, Fitzkee NC. Exploring Residue-Level Interactions between the Biofilm-Driving R2ab Protein and Polystyrene Nanoparticles. Langmuir : the Acs Journal of Surfaces and Colloids. 40: 1213-1222. PMID 38174900 DOI: 10.1021/acs.langmuir.3c02609 |
0.106 |
|
2023 |
Somarathne RP, Misra SK, Kariyawasam CS, Kessl JJ, Sharp JS, Fitzkee NC. Exploring the Residue-Level Interactions between the R2ab Protein and Polystyrene Nanoparticles. Biorxiv : the Preprint Server For Biology. PMID 37693402 DOI: 10.1101/2023.08.28.554951 |
0.104 |
|
2002 |
DeLabre ML, Kessl J, Karamanou S, Trumpower BL. RPL29 codes for a non-essential protein of the 60S ribosomal subunit in Saccharomyces cerevisiae and exhibits synthetic lethality with mutations in genes for proteins required for subunit coupling. Biochimica Et Biophysica Acta. 1574: 255-61. PMID 11997090 DOI: 10.1016/S0167-4781(01)00372-4 |
0.089 |
|
Hide low-probability matches. |