Gerald Litwack - Related publications

1964-1991 Temple University, Philadelphia, PA, United States 
 1991-2003 Pharmacology Thomas Jefferson University 
glucocorticoid receptor
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Gao J, Yuan X, Zheng X, Zhao X, Wang T, Liang Q, Xiao C, Wang J, Li Q, Zhao X. Two-point immobilization of a conformation-specific beta-adrenoceptor for recognizing the receptor agonists or antagonists inspired by binding-induced DNA assembly. Biomaterials Science. PMID 34704989 DOI: 10.1039/d1bm01222c   
2021 Wookey P, Gupta P, Bittencourt L, Cheung S, Hare D, Furness S. Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy. F1000research. 10: 1019. PMID 34745567 DOI: 10.12688/f1000research.72845.1   
2021 Steindorf D, Loeuillet A, Bagnard D, Strand S, Schneider D. Increased stability of the TM helix oligomer abrogates the apoptotic activity of the human Fas receptor. Biochimica Et Biophysica Acta. Biomembranes. 1864: 183807. PMID 34662567 DOI: 10.1016/j.bbamem.2021.183807   
2021 Floeser A, Becker K, Kostenis E, König G, Krasel C, Kolb P, Buenemann M. Disentangling bias between G, GRK2, and arrestin3 recruitment to the M muscarinic acetylcholine receptor. Elife. 10. PMID 34851820 DOI: 10.7554/eLife.58442   
2021 Suresh M, Li B, Huang X, Korolowicz KE, Murreddu MG, Gudima SO, Menne S. Agonistic Activation of Cytosolic DNA Sensing Receptors in Woodchuck Hepatocyte Cultures and Liver for Inducing Antiviral Effects. Frontiers in Immunology. 12: 745802. PMID 34671360 DOI: 10.3389/fimmu.2021.745802   
2021 Buwaneka P, Ralko A, Gorai S, Pham H, Cho W. Phosphoinositide binding activity of Smad2 is essential for its function in TGF-β signaling. The Journal of Biological Chemistry. 101303. PMID 34655614 DOI: 10.1016/j.jbc.2021.101303   
2021 Garnelo Gómez B, Holzwart E, Shi C, Lozano-Durán R, Wolf S. Phosphorylation-dependent routing of RLP44 towards brassinosteroid or phytosulfokine signalling. Journal of Cell Science. 134. PMID 34569597 DOI: 10.1242/jcs.259134   
2021 Wines BD, Trist HM, Esparon S, Impey RE, Mackay GA, Andrews RK, Soares da Costa TP, Pietersz GA, Baker RI, Hogarth PM. Fc Binding by FcγRIIa Is Essential for Cellular Activation by the Anti-FcγRIIa mAbs 8.26 and 8.2. Frontiers in Immunology. 12: 666813. PMID 34759915 DOI: 10.3389/fimmu.2021.666813   
2021 Sapkota K, Burnell ES, Irvine MW, Fang G, Gawande DY, Dravid SM, Jane DE, Monaghan DT. Pharmacological characterization of a novel negative allosteric modulator of NMDA receptors, UBP792. Neuropharmacology. 201: 108818. PMID 34610288 DOI: 10.1016/j.neuropharm.2021.108818   
2021 Wang W, Bian J, Sun Y, Li Z. The new fate of internalized membrane receptors: Internalized activation. Pharmacology & Therapeutics. 108018. PMID 34626676 DOI: 10.1016/j.pharmthera.2021.108018   
2021 Mitra A, Sarkar A, Borics A. Universal Properties and Specificities of the β-Adrenergic Receptor-G Protein Complex Activation Mechanism Revealed by All-Atom Molecular Dynamics Simulations. International Journal of Molecular Sciences. 22. PMID 34638767 DOI: 10.3390/ijms221910423   
2021 Khan SA, Zia K, Ashraf S, Khan A, Ul-Haq Z. Theoretical investigation of selective ligand binding mode of galanin receptors. Journal of Biomolecular Structure & Dynamics. 1-11. PMID 34632940 DOI: 10.1080/07391102.2021.1977703   
2021 Islam MR, Teleb M, Karageorgos V, Sakellaris S, Papadopoulos M, Pirmettis I, Fronczek FR, Liapakis G, Fahmy H. Design, Synthesis, Structural Optimization, SAR, in silico Prediction of Physicochemical Properties and Pharmacological Evaluation of Novel & Potent Thiazolo[4,5-d]pyrimidine Corticotropin Releasing Factor (CRF) Receptor Antagonists. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 106084. PMID 34856350 DOI: 10.1016/j.ejps.2021.106084   
2021 Wang M, Hou S, Liu Y, Li D, Lin J. Identification of Novel Antagonists Targeting Cannabinoid Receptor 2 Using a Multi-Step Virtual Screening Strategy. Molecules (Basel, Switzerland). 26. PMID 34771087 DOI: 10.3390/molecules26216679   
2021 Liu T, Yi TL, Yang DQ, Tao YX. Regulation of melanocortin-5 receptor pharmacology by two isoforms of MRAP2 in ricefield eel (Monopterus albus). General and Comparative Endocrinology. 113928. PMID 34653433 DOI: 10.1016/j.ygcen.2021.113928   
2021 Biswas AD, Catte A, Mancini G, Barone V. Analysis of L-DOPA and Droxidopa binding to Human β-Adrenergic Receptor. Biophysical Journal. PMID 34767786 DOI: 10.1016/j.bpj.2021.11.007   
2021 Raj S, Lu L, Unsworth LD. Screening Peptides that Activate MRGPRX2 using Engineered HEK Cells. Journal of Visualized Experiments : Jove. PMID 34806705 DOI: 10.3791/62448   
2021 Lou L, Li C, Wang J, Wu A, Zhang T, Ma Z, Chai L, Zhang D, Zhao Y, Nie B, Jin Q, Chen H, Liu WJ. Yiqi Huoxue preserves heart function by upregulating the Sigma-1 receptor in rats with myocardial infarction. Experimental and Therapeutic Medicine. 22: 1308. PMID 34630662 DOI: 10.3892/etm.2021.10743   
2021 Connelly SM, Sridharan R, Naider F, Dumont ME. Oligomerization of Yeast α-factor Receptor Detected by Fluorescent Energy Transfer Between Ligands. Biophysical Journal. PMID 34627767 DOI: 10.1016/j.bpj.2021.10.005   
2021 Zhang F, Chen X, Chen J, Xu Y, Li S, Guo Y, Pu X. Probing Allosteric Regulation Mechanism of W7.35 on Agonist-Induced Activity for μOR by Mutation Simulation. Journal of Chemical Information and Modeling. PMID 34779608 DOI: 10.1021/acs.jcim.1c00650   
2021 Vidad AR, Macaspac S, Ng HL. Locating ligand binding sites in G-protein coupled receptors using combined information from docking and sequence conservation. Peerj. 9: e12219. PMID 34631323 DOI: 10.7717/peerj.12219   
2021 Song J, Chow RD, Pena-Hernandez M, Zhang L, Loeb SA, So EY, Liang OD, Wilen CB, Lee S. LRRC15 is an inhibitory receptor blocking SARS-CoV-2 spike-mediated entry . Biorxiv : the Preprint Server For Biology. PMID 34845449 DOI: 10.1101/2021.11.23.469714   
2021 Li YL, Li YX, Wang XP, Kang XL, Guo KQ, Dong DJ, Wang JX, Zhao XF. Identification and Functional Analysis of G Protein-Coupled Receptors in 20-Hydroxyecdysone Signaling From the Genome. Frontiers in Cell and Developmental Biology. 9: 753787. PMID 34765604 DOI: 10.3389/fcell.2021.753787   
2021 Jagleniec D, Walczak N, Dobrzycki Ł, Romański J. Utilizing an Amino Acid Scaffold to Construct Heteroditopic Receptors Capable of Interacting with Salts under Interfacial Conditions. International Journal of Molecular Sciences. 22. PMID 34639095 DOI: 10.3390/ijms221910754   
2021 Hunt JP, Galiardi J, Free TJ, Yang SO, Poole D, Zhao EL, Andersen JL, Wood DW, Bundy BC. Mechanistic discoveries and simulation-guided assay optimization of portable hormone biosensors with cell-free protein synthesis. Biotechnology Journal. e2100152. PMID 34761537 DOI: 10.1002/biot.202100152   
2021 Bachurin SO, Makhaeva GF, Shevtsova EF, Aksinenko AY, Grigoriev VV, Shevtsov PN, Goreva TV, Epishina TA, Kovaleva NV, Pushkareva EA, Boltneva NP, Lushchekina SV, Gabrelyan AV, Zamoyski VL, Dubova LG, et al. Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands. Molecules (Basel, Switzerland). 26. PMID 34576998 DOI: 10.3390/molecules26185527   
2021 Gysel K, Laursen M, Thygesen MB, Lironi D, Bozsóki Z, Hjuler CT, Maolanon NN, Cheng J, Bjørk PK, Vinther M, Madsen LH, Rübsam H, Muszyński A, Ghodrati A, Azadi P, et al. Kinetic proofreading of lipochitooligosaccharides determines signal activation of symbiotic plant receptors. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34716271 DOI: 10.1073/pnas.2111031118   
2021 Tan ZC, Meyer AS. A general model of multivalent binding with ligands of heterotypic subunits and multiple surface receptors. Mathematical Biosciences. 108714. PMID 34637774 DOI: 10.1016/j.mbs.2021.108714   
2021 Raïch I, Rivas-Santisteban R, Lillo A, Lillo J, Reyes-Resina I, Nadal X, Ferreiro-Vera C, de Medina VS, Majellaro M, Sotelo E, Navarro G, Franco R. Similarities and differences upon binding of naturally occurring Δ-tetrahydrocannabinol-derivatives to cannabinoid CB and CB receptors. Pharmacological Research. 174: 105970. PMID 34758399 DOI: 10.1016/j.phrs.2021.105970   
2021 Mann G, Kadiyala KG, Thirumal M, Tiwari AK, Datta A. Receptor mapping using methoxy phenyl piperazine derivative: Preclinical PET imaging. Bioorganic Chemistry. 117: 105429. PMID 34736134 DOI: 10.1016/j.bioorg.2021.105429   
2021 Wolf P, Mohr A, Gavins G, Behr V, Mörl K, Seitz O, Beck-Sickinger AG. Orthogonal Peptide-Templated Labeling Elucidates Lateral ET R/ET R Proximity and Reveals Altered Downstream Signaling. Chembiochem : a European Journal of Chemical Biology. PMID 34699123 DOI: 10.1002/cbic.202100340   
2021 Cai X, Yao Y, Teng F, Li Y, Wu L, Yan W, Lin N. The role of P2X7 receptor in infection and metabolism: Based on inflammation and immunity. International Immunopharmacology. 101: 108297. PMID 34717202 DOI: 10.1016/j.intimp.2021.108297   
2021 Cheng X, Yin C, Deng Y, Li Z. Exogenous adenosine activates A2A adenosine receptor to inhibit RANKL-induced osteoclastogenesis via AP-1 pathway to facilitate bone repair. Molecular Biology Reports. PMID 34846650 DOI: 10.1007/s11033-021-07017-1   
2021 Mikuła R, Pruszyńska-Oszmałek E, Pszczola M, Rząsińska J, Sassek M, Nowak KW, Nogowski L, Kołodziejski PA. Changes in metabolic and hormonal profiles during transition period in dairy cattle - the role of spexin. Bmc Veterinary Research. 17: 359. PMID 34798894 DOI: 10.1186/s12917-021-03069-4   
2021 Yan W, Fan L, Yu J, Liu R, Wang H, Tan L, Wang S, Cheng J. 2-Phenylcyclopropylmethylamine Derivatives as Dopamine D Receptor Partial Agonists: Design, Synthesis, and Biological Evaluation. Journal of Medicinal Chemistry. PMID 34797051 DOI: 10.1021/acs.jmedchem.1c01327   
2021 Matsushita Y, Manabe M, Kitagawa I, Higuchi M, Hosaka YZ, Kitamura N. Inhibition of transient receptor potential vanilloid type 1 through α adrenergic receptors at peripheral nerve terminals relieves pain. The Journal of Veterinary Medical Science. 83: 1570-1581. PMID 34470979 DOI: 10.1292/jvms.21-0429   
2021 Romero-Martínez BS, Montaño LM, Solís-Chagoyán H, Sommer B, Ramírez-Salinas GL, Pérez-Figueroa GE, Flores-Soto E. Possible Beneficial Actions of Caffeine in SARS-CoV-2. International Journal of Molecular Sciences. 22. PMID 34067243 DOI: 10.3390/ijms22115460   
2021 Hoglin BE, Miner M, Dores RM. Pharmacological properties of whale shark (Rhincodon typus) melanocortin-2 receptor and melancortin-5 receptor: Interaction with MRAP1 and MRAP2. General and Comparative Endocrinology. 113915. PMID 34607718 DOI: 10.1016/j.ygcen.2021.113915   
2021 Rečnik LM, Thatcher RJ, Mallah S, Butts CP, Collingridge GL, Molnár E, Jane DE, Willis CL. Synthesis and pharmacological characterisation of arctigenin analogues as antagonists of AMPA and kainate receptors. Organic & Biomolecular Chemistry. 19: 9154-9162. PMID 34642722 DOI: 10.1039/d1ob01653a   
2021 Chou WC, Rampanelli E, Li X, Ting JP. Impact of intracellular innate immune receptors on immunometabolism. Cellular & Molecular Immunology. PMID 34697412 DOI: 10.1038/s41423-021-00780-y   
2021 Nagarajan SK, Babu S, Devaraju P, Sohn H, Madhavan T. Structure and dynamics of the Somatostatin receptor 3 (SSTR3)-ligand binding in presence of lipids examined using computational structural biology methods. Proteins. PMID 34661304 DOI: 10.1002/prot.26267   
2021 Sprague DJ, Getschman AE, Fenske TG, Volkman BF, Smith BC. Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12. Acs Medicinal Chemistry Letters. 12: 1773-1782. PMID 34795867 DOI: 10.1021/acsmedchemlett.1c00388   
2021 Jenkins L, Marsango S, Mancini S, Mahmud ZA, Morrison A, McElroy SP, Bennett KA, Barnes M, Tobin AB, Tikhonova IG, Milligan G. Discovery and Characterization of Novel Antagonists of the Proinflammatory Orphan Receptor GPR84. Acs Pharmacology & Translational Science. 4: 1598-1613. PMID 34661077 DOI: 10.1021/acsptsci.1c00151   
2021 Rivera R, Williams NA, Kennedy GG, Sánchez-Pavón P, Chun J. Generation of an Lpar1-EGFP Fusion Knock-in Transgenic Mouse Line. Cell Biochemistry and Biophysics. 79: 619-627. PMID 34652685 DOI: 10.1007/s12013-021-01033-5   
2021 Rudolf S, Kaempf K, Vu O, Meiler J, Beck-Sickinger AG, Coin I. Binding of Natural Peptide Ligands to the Neuropeptide Y5 Receptor. Angewandte Chemie (International Ed. in English). PMID 34822209 DOI: 10.1002/anie.202108738   
2021 He X, Zhang Y, Xu Y, Xie L, Yu Z, Zheng J. The function of P2 × 7 receptor in hematopoiesis and leukemogenesis. Experimental Hematology. PMID 34687808 DOI: 10.1016/j.exphem.2021.10.001   
2021 Bolt MJ, Singh P, Obkirchner CE, Powell RT, Mancini MG, Szafran AT, Stossi F, Mancini MA. Endocrine disrupting chemicals differentially alter intranuclear dynamics and transcriptional activation of estrogen receptor-α. Iscience. 24: 103227. PMID 34712924 DOI: 10.1016/j.isci.2021.103227   
2021 Catar RA, Wischnewski O, Chen L, Heidecke H, Rutz C, Schülein R, Dragun D, Philippe A, Kusch A. Non-HLA antibodies targeting angiotensin II type 1 receptors and endothelin-1 type A receptors impair endothelial repair via a β2-arrestin link to the mTOR pathway. Kidney International. PMID 34757123 DOI: 10.1016/j.kint.2021.09.029   
2021 Song Y, Deng X, Shi W, Tang F, Huang W, Gong L, Qin Q. A homogeneous time-resolved fluorometric energy transfer assay for the binding assessment of FcRn with IgG antibodies. Journal of Immunological Methods. 113180. PMID 34736962 DOI: 10.1016/j.jim.2021.113180   
2021 Austin JR, Li K, Rivera Rodríguez R, Lantvit DD, Murphy BT, Burdette JE. Irilone, a Red Clover Isoflavone, Combined with Progesterone Enhances PR Signaling through the Estrogen and Glucocorticoid Receptors. Journal of Natural Products. PMID 34813298 DOI: 10.1021/acs.jnatprod.1c00835