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Rami Al-Horani - Publications

Affiliations: 
2007-2011 Virginia Commonwealth University, Richmond, VA, United States 
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44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Vu KT, Kar S, Goyal N, Mottamal M, Afosah DK, Al-Horani RA. Discovery of Heparin Mimetic, Potent, and Selective Inhibitors of Human Clotting Factor XIIIa. Acs Omega. 9: 31105-31119. PMID 39035933 DOI: 10.1021/acsomega.4c04518  0.535
2024 Al-Horani RA. Revisiting the effect of cholesteryl sulfate on clotting and fibrinolysis: Inhibition of human thrombin and other human blood proteases. Heliyon. 10: e28017. PMID 38533078 DOI: 10.1016/j.heliyon.2024.e28017  0.371
2024 Woodland MD, Thompson A, Lipford A, Goyal N, Schexnaildre JC, Mottamal M, Afosah DK, Al-Horani RA. New Triazole-Based Potent Inhibitors of Human Factor XIIa as Anticoagulants. Acs Omega. 9: 10694-10708. PMID 38463342 DOI: 10.1021/acsomega.3c09335  0.515
2023 Afosah DK, Fayyad RM, Puliafico VR, Merrell S, Langmia EK, Diagne SR, Al-Horani RA, Desai UR. Homogeneous, Synthetic, Non-Saccharide Glycosaminoglycan Mimetics as Potent Inhibitors of Human Cathepsin G. Biomolecules. 13. PMID 37238630 DOI: 10.3390/biom13050760  0.785
2023 Chiles R, Afosah DK, Al-Horani RA. Investigation of the anticoagulant activity of cyclic sulfated glycosaminoglycan mimetics. Carbohydrate Research. 529: 108831. PMID 37209666 DOI: 10.1016/j.carres.2023.108831  0.378
2023 Al-Horani RA, Afosah DK, Kar S, Aliter KF, Mottamal M. Sulphated penta-galloyl glucopyranoside (SPGG) is glycosaminoglycan mimetic allosteric inhibitor of cathepsin G. Rps Pharmacy and Pharmacology Reports. 2: rqad001. PMID 36844783 DOI: 10.1093/rpsppr/rqad001  0.309
2023 Al-Horani RA. 6-(Arylaminomethyl) Isoquinolines as Enzyme Inhibitors and Their Preparation: A Patent Highlight of Factor XIIa Inhibitors. Cardiovascular & Hematological Agents in Medicinal Chemistry. PMID 36703578 DOI: 10.2174/1871525721666230126114224  0.381
2022 Al-Horani RA, Afosah DK, Mottamal M. Triazol-1-yl Benzamides Promote Anticoagulant Activity via Inhibition of Factor XIIa. Cardiovascular & Hematological Agents in Medicinal Chemistry. PMID 36321236 DOI: 10.2174/1871525721666221031141323  0.436
2022 Al-Horani RA, Parsaeian E, Mohammad M, Mottamal M. Sulfonated non-saccharide molecules and human factor XIa: Enzyme inhibition and computational studies. Chemical Biology & Drug Design. PMID 35377529 DOI: 10.1111/cbdd.14053  0.521
2022 Afosah DK, Ofori E, Mottamal M, Al-Horani RA. Factor IX(a) inhibitors: an updated patent review (2003-present). Expert Opinion On Therapeutic Patents. 32: 381-400. PMID 34991418 DOI: 10.1080/13543776.2022.2026926  0.343
2021 Kar S, Bankston P, Afosah DK, Al-Horani RA. Lignosulfonic Acid Sodium Is a Noncompetitive Inhibitor of Human Factor XIa. Pharmaceuticals (Basel, Switzerland). 14. PMID 34577586 DOI: 10.3390/ph14090886  0.41
2021 Al-Horani RA, Aliter KF, Kar S, Mottamal M. Sulfonated Nonsaccharide Heparin Mimetics Are Potent and Noncompetitive Inhibitors of Human Neutrophil Elastase. Acs Omega. 6: 12699-12710. PMID 34056422 DOI: 10.1021/acsomega.1c00935  0.494
2020 Kar S, Mottamal M, Al-Horani RA. Discovery of Benzyl Tetraphosphonate Derivative as Inhibitor of Human Factor Xia. Chemistryopen. 9: 1161-1172. PMID 33204588 DOI: 10.1002/open.202000277  0.544
2020 Boothello RS, Sankaranarayanan NV, Afosah DK, Karuturi R, Al-Horani RA, Desai UR. Studies on fragment-based design of allosteric inhibitors of human factor XIa. Bioorganic & Medicinal Chemistry. 28: 115762. PMID 32992249 DOI: 10.1016/J.Bmc.2020.115762  0.852
2020 Al-Horani RA. Potential Therapeutic Roles for Direct Factor Xa Inhibitors in Coronavirus Infections. American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions. PMID 32918208 DOI: 10.1007/s40256-020-00438-6  0.388
2020 Aliter KF, Al-Horani RA. Thrombin Inhibition by Argatroban: Potential Therapeutic Benefits in COVID-19. Cardiovascular Drugs and Therapy. PMID 32870433 DOI: 10.1007/s10557-020-07066-x  0.394
2020 Al-Horani RA, Kar S. Factor XIIIa inhibitors as potential novel drugs for venous thromboembolism. European Journal of Medicinal Chemistry. 200: 112442. PMID 32502864 DOI: 10.1016/j.ejmech.2020.112442  0.46
2020 Al-Horani RA, Mottamal M. Sulfonated Arylurea Derivatives are Potent Inhibitors of Human Neutrophil Elastase The Faseb Journal. 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.04403  0.34
2019 Al-Horani RA. Factor XI(a) inhibitors for thrombosis: an updated patent review (2016-present). Expert Opinion On Therapeutic Patents. 1-17. PMID 31847619 DOI: 10.1080/13543776.2020.1705783  0.416
2019 Al-Horani RA, Abdelfadiel EI, Afosah DK, Morla S, Sistla JC, Mohammed B, Martin EJ, Sakagami M, Brophy DF, Desai UR. A Synthetic Heparin Mimetic That Allosterically Inhibits Factor XIa and Reduces Thrombosis In Vivo Without Enhanced Risk of Bleeding. Journal of Thrombosis and Haemostasis : Jth. PMID 31397071 DOI: 10.1111/Jth.14606  0.707
2019 Al-Horani RA, Clemons D, Mottamal M. The In Vitro Effects of Pentamidine Isethionate on Coagulation and Fibrinolysis. Molecules (Basel, Switzerland). 24. PMID 31174390 DOI: 10.3390/molecules24112146  0.321
2018 Afosah DK, Al-Horani RA. Sulfated Non-Saccharide Glycosaminoglycan Mimetics as Novel Drug Discovery Platform for Various Pathologies. Current Medicinal Chemistry. PMID 30457046 DOI: 10.2174/0929867325666181120101147  0.8
2018 Gangji RN, Sankaranarayanan NV, Elste J, Al-Horani RA, Afosah DK, Joshi R, Tiwari V, Desai UR. Inhibition of Herpes Simplex Virus-1 Entry into Human Cells by Nonsaccharide Glycosaminoglycan Mimetics. Acs Medicinal Chemistry Letters. 9: 797-802. PMID 30128070 DOI: 10.1021/Acsmedchemlett.7B00364  0.721
2018 Al-Horani RA, Afosah DK. Recent advances in the discovery and development of factor XI/XIa inhibitors. Medicinal Research Reviews. 38: 1974-2023. PMID 29727017 DOI: 10.1002/med.21503  0.828
2018 Afosah DK, Verespy S, Al-Horani RA, Boothello RS, Karuturi R, Desai UR. A small group of sulfated benzofurans induces steady-state submaximal inhibition of thrombin. Bioorganic & Medicinal Chemistry Letters. PMID 29459207 DOI: 10.1016/J.Bmcl.2018.01.069  0.759
2017 Obaidullah AJ, Al-Horani RA. Discovery of Chromen-7-yl Furan-2-Carboxylate as a Potent and Selective Factor XIa Inhibitor. Cardiovascular & Hematological Agents in Medicinal Chemistry. 15: 40-48. PMID 28552062 DOI: 10.2174/1871525715666170529093938  0.438
2016 Afosah DK, Al-Horani RA, Sankaranarayanan NV, Desai UR. Potent, Selective, Allosteric Inhibition of Human Plasmin by Sulfated Non-Saccharide Glycosaminoglycan Mimetics. Journal of Medicinal Chemistry. PMID 27976897 DOI: 10.1021/acs.jmedchem.6b01474  0.82
2016 Al-Horani RA, Karuturi R, Lee M, Afosah DK, Desai UR. Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile. Plos One. 11: e0160189. PMID 27467511 DOI: 10.1371/journal.pone.0160189  0.85
2016 Verespy Iii S, Mehta AY, Afosah D, Al-Horani RA, Desai UR. Allosteric Partial Inhibition of Monomeric Proteases. Sulfated Coumarins Induce Regulation, not just Inhibition, of Thrombin. Scientific Reports. 6: 24043. PMID 27053426 DOI: 10.1038/Srep24043  0.817
2016 Al-Horani RA, Desai UR. Factor XIa inhibitors: A review of the patent literature. Expert Opinion On Therapeutic Patents. PMID 26881476 DOI: 10.1517/13543776.2016.1154045  0.571
2015 Al-Horani RA, Gailani D, Desai UR. Allosteric inhibition of factor XIa. Sulfated non-saccharide glycosaminoglycan mimetics as promising anticoagulants. Thrombosis Research. 136: 379-87. PMID 25935648 DOI: 10.1016/J.Thromres.2015.04.017  0.7
2015 Al-Horani RA, Karuturi R, White DT, Desai UR. Plasmin regulation through allosteric, sulfated, small molecules. Molecules (Basel, Switzerland). 20: 608-24. PMID 25569517 DOI: 10.3390/molecules20010608  0.676
2015 Boothello RS, Al-Horani RA, Desai UR. Glycosaminoglycan-protein interaction studies using fluorescence spectroscopy. Methods in Molecular Biology (Clifton, N.J.). 1229: 335-53. PMID 25325964 DOI: 10.1007/978-1-4939-1714-3_27  0.776
2015 Al-Horani RA, Karuturi R, Verespy S, Desai UR. Synthesis of glycosaminoglycan mimetics through sulfation of polyphenols. Methods in Molecular Biology (Clifton, N.J.). 1229: 49-67. PMID 25325944 DOI: 10.1007/978-1-4939-1714-3_7  0.769
2014 Al-Horani RA. Serpin regulation of fibrinolytic system: implications for therapeutic applications in cardiovascular diseases. Cardiovascular & Hematological Agents in Medicinal Chemistry. 12: 91-125. PMID 25374013  0.361
2014 Patel NJ, Karuturi R, Al-Horani RA, Baranwal S, Patel J, Desai UR, Patel BB. Synthetic, non-saccharide, glycosaminoglycan mimetics selectively target colon cancer stem cells. Acs Chemical Biology. 9: 1826-33. PMID 24968014 DOI: 10.1021/cb500402f  0.579
2014 Al-Horani RA, Desai UR. Designing allosteric inhibitors of factor XIa. Lessons from the interactions of sulfated pentagalloylglucopyranosides. Journal of Medicinal Chemistry. 57: 4805-18. PMID 24844380 DOI: 10.1021/jm500311e  0.673
2014 Al-Horani RA, Desai UR. Recent advances on plasmin inhibitors for the treatment of fibrinolysis-related disorders. Medicinal Research Reviews. 34: 1168-216. PMID 24659483 DOI: 10.1002/Med.21315  0.653
2013 Karuturi R, Al-Horani RA, Mehta SC, Gailani D, Desai UR. Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site. Journal of Medicinal Chemistry. 56: 2415-28. PMID 23451707 DOI: 10.1021/Jm301757V  0.654
2013 Al-Horani RA, Ponnusamy P, Mehta AY, Gailani D, Desai UR. Sulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIa. Journal of Medicinal Chemistry. 56: 867-78. PMID 23316863 DOI: 10.1021/Jm301338Q  0.834
2012 Al-Horani RA, Mehta AY, Desai UR. Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold. European Journal of Medicinal Chemistry. 54: 771-83. PMID 22770607 DOI: 10.1016/J.Ejmech.2012.06.032  0.81
2012 Al-Horani RA, Desai UR. Electronically Rich N-Substituted Tetrahydroisoquinoline 3-Carboxylic Acid Esters: Concise Synthesis and Conformational Studies. Tetrahedron. 68: 2027-2040. PMID 22665943 DOI: 10.1016/J.Tet.2012.01.005  0.492
2011 Al-Horani RA, Liang A, Desai UR. Designing nonsaccharide, allosteric activators of antithrombin for accelerated inhibition of factor Xa. Journal of Medicinal Chemistry. 54: 6125-38. PMID 21800826 DOI: 10.1021/Jm2008387  0.794
2010 Al-Horani RA, Desai UR. Chemical Sulfation of Small Molecules - Advances and Challenges. Tetrahedron. 66: 2907-2918. PMID 20689724 DOI: 10.1016/J.Tet.2010.02.015  0.5
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