| Year |
Citation |
Score |
| 2018 |
Abdul-Razak HH, Rocca CJ, Howe SJ, Alonso-Ferrero ME, Wang J, Gabriel R, Bartholomae CC, Gan CHV, Garín MI, Roberts A, Blundell MP, Prakash V, Molina-Estevez FJ, Pantoglou J, Guenechea G, ... ... Kinnon C, et al. Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency. Scientific Reports. 8: 8214. PMID 29844458 DOI: 10.1038/S41598-018-26439-9 |
0.384 |
|
| 2017 |
Alonso-Ferrero ME, van Til NP, Bartolovic K, Mata MF, Wagemaker G, Moulding D, Williams DA, Kinnon C, Waddington SN, Milsom MD, Howe SJ. Enhancement of mouse hematopoietic stem/progenitor cell function via transient gene delivery using integration-deficient lentiviral vectors. Experimental Hematology. PMID 28911908 DOI: 10.1016/J.Exphem.2017.09.003 |
0.425 |
|
| 2011 |
Gaspar HB, Cooray S, Gilmour KC, Parsley KL, Adams S, Howe SJ, Al Ghonaium A, Bayford J, Brown L, Davies EG, Kinnon C, Thrasher AJ. Long-term persistence of a polyclonal T cell repertoire after gene therapy for X-linked severe combined immunodeficiency. Science Translational Medicine. 3: 97ra79. PMID 21865537 DOI: 10.1126/Scitranslmed.3002715 |
0.449 |
|
| 2011 |
Abeyewickreme A, Thrasher AJ, Kinnon C. Bone morphogenetic protein-4 (BMP4) up regulates key haematopoietic genes in differentiating embryonic stem cells treated with BMP4 short hairpin RNA British Journal of Haematology. 155: 638-641. PMID 21749358 DOI: 10.1111/J.1365-2141.2011.08759.X |
0.316 |
|
| 2011 |
Ward NJ, Buckley SM, Waddington SN, Vandendriessche T, Chuah MK, Nathwani AC, McIntosh J, Tuddenham EG, Kinnon C, Thrasher AJ, McVey JH. Codon optimization of human factor VIII cDNAs leads to high-level expression. Blood. 117: 798-807. PMID 21041718 DOI: 10.1182/Blood-2010-05-282707 |
0.372 |
|
| 2011 |
Santilli G, Almarza E, Brendel C, Choi U, Beilin C, Blundell MP, Haria S, Parsley KL, Kinnon C, Malech HL, Bueren JA, Grez M, Thrasher AJ. Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 122-32. PMID 20978475 DOI: 10.1038/Mt.2010.226 |
0.48 |
|
| 2009 |
Blundell MP, Bouma G, Metelo J, Worth A, Calle Y, Cowell LA, Westerberg LS, Moulding DA, Mirando S, Kinnon C, Cory GO, Jones GE, Snapper SB, Burns SO, Thrasher AJ. Phosphorylation of WASp is a key regulator of activity and stability in vivo. Proceedings of the National Academy of Sciences of the United States of America. 106: 15738-43. PMID 19805221 DOI: 10.1073/Pnas.0904346106 |
0.336 |
|
| 2008 |
Howe SJ, Mansour MR, Schwarzwaelder K, Bartholomae C, Hubank M, Kempski H, Brugman MH, Pike-Overzet K, Chatters SJ, De Ridder D, Gilmour KC, Adams S, Thornhill SI, Parsley KL, Staal FJT, ... ... Kinnon C, et al. Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients Journal of Clinical Investigation. 118: 3143-3150. PMID 18688286 DOI: 10.1172/Jci35798 |
0.44 |
|
| 2008 |
Blundell MP, Bouma G, Calle Y, Jones GE, Kinnon C, Thrasher AJ. Improvement of migratory defects in a murine model of Wiskott-Aldrich syndrome gene therapy Molecular Therapy. 16: 836-844. PMID 18388921 DOI: 10.1038/Mt.2008.43 |
0.456 |
|
| 2008 |
Santilli G, Thornhill SI, Kinnon C, Thrasher AJ. Gene therapy of inherited immunodeficiencies Expert Opinion On Biological Therapy. 8: 397-407. PMID 18352845 DOI: 10.1517/14712598.8.4.397 |
0.397 |
|
| 2008 |
Thornhill SI, Schambach A, Howe SJ, Ulaganathan M, Grassman E, Williams D, Schiedlmeier B, Sebire NJ, Gaspar HB, Kinnon C, Baum C, Thrasher AJ. Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 590-8. PMID 18180772 DOI: 10.1038/Sj.Mt.6300393 |
0.399 |
|
| 2007 |
Marshall CJ, Sinclair JC, Thrasher AJ, Kinnon C. Bone morphogenetic protein 4 modulates c-Kit expression and differentiation potential in murine embryonic aorta-gonad-mesonephros haematopoiesis in vitro British Journal of Haematology. 139: 321-330. PMID 17897310 DOI: 10.1111/J.1365-2141.2007.06795.X |
0.343 |
|
| 2007 |
Moulding DA, Blundell MP, Spiller DG, White MR, Cory GO, Calle Y, Kempski H, Sinclair J, Ancliff PJ, Kinnon C, Jones GE, Thrasher AJ. Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia. The Journal of Experimental Medicine. 204: 2213-24. PMID 17724125 DOI: 10.1084/Jem.20062324 |
0.385 |
|
| 2007 |
Schwarzwaelder K, Howe SJ, Schmidt M, Brugman MH, Deichmann A, Glimm H, Schmidt S, Prinz C, Wissler M, King DJS, Zhang F, Parsley KL, Gilmour KC, Sinclair J, Bayford J, ... ... Kinnon C, et al. Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo Journal of Clinical Investigation. 117: 2241-2249. PMID 17671654 DOI: 10.1172/Jci31661 |
0.425 |
|
| 2007 |
Karlsson H, Brewin J, Kinnon C, Veys P, Amrolia PJ. Generation of trispecific cytotoxic T cells recognizing cytomegalovirus, adenovirus, and Epstein-Barr virus: an approach for adoptive immunotherapy of multiple pathogens. Journal of Immunotherapy (Hagerstown, Md. : 1997). 30: 544-56. PMID 17589295 DOI: 10.1097/Cji.0B013E3180335B7A |
0.363 |
|
| 2007 |
Zhang F, Thornhill SI, Howe SJ, Ulaganathan M, Schambach A, Sinclair J, Kinnon C, Gaspar HB, Antoniou M, Thrasher AJ. Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells Blood. 110: 1448-1457. PMID 17456723 DOI: 10.1182/Blood-2006-12-060814 |
0.429 |
|
| 2007 |
Qasim W, Mackey T, Sinclair J, Chatziandreou I, Kinnon C, Thrasher AJ, Gaspar HB. Lentiviral vectors for T-cell suicide gene therapy: Preservation of T-cell effector function after cytokine-mediated transduction Molecular Therapy. 15: 355-360. PMID 17235314 DOI: 10.1038/Sj.Mt.6300042 |
0.419 |
|
| 2007 |
Chatziandreou I, Gilmour KC, McNicol AM, Costabile M, Sinclair J, Cubitt D, Campbell JDM, Kinnon C, Qasim W, Bobby Gaspar H. Capture and generation of adenovirus specific T cells for adoptive immunotherapy British Journal of Haematology. 136: 117-126. PMID 17092305 DOI: 10.1111/J.1365-2141.2006.06386.X |
0.381 |
|
| 2006 |
Gaspar HB, Bjorkegren E, Parsley K, Gilmour KC, King D, Sinclair J, Zhang F, Giannakopoulos A, Adams S, Fairbanks LD, Gaspar J, Henderson L, Xu-Bayford JH, Davies EG, Veys PA, ... Kinnon C, et al. Successful reconstitution of immunity in ADA-SCID by stem cell gene therapy following cessation of PEG-ADA and use of mild preconditioning. Molecular Therapy : the Journal of the American Society of Gene Therapy. 14: 505-13. PMID 16905365 DOI: 10.1016/J.Ymthe.2006.06.007 |
0.412 |
|
| 2006 |
Ancliff PJ, Blundell MP, Cory GO, Calle Y, Worth A, Kempski H, Burns S, Jones GE, Sinclair J, Kinnon C, Hann IM, Gale RE, Linch DC, Thrasher AJ. Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia. Blood. 108: 2182-9. PMID 16804117 DOI: 10.1182/Blood-2006-01-010249 |
0.376 |
|
| 2006 |
Kinnon C. Gene therapy: has it delivered what it promised? British Journal of Hospital Medicine (London, England : 2005). 67: 228-9. PMID 16729623 DOI: 10.12968/Hmed.2006.67.5.21058 |
0.309 |
|
| 2006 |
Yáñez-Muñoz RJ, Balaggan KS, MacNeil A, Howe SJ, Schmidt M, Smith AJ, Buch P, MacLaren RE, Anderson PN, Barker SE, Duran Y, Bartholomae C, von Kalle C, Heckenlively JR, Kinnon C, et al. Effective gene therapy with nonintegrating lentiviral vectors. Nature Medicine. 12: 348-53. PMID 16491086 DOI: 10.1038/Nm1365 |
0.382 |
|
| 2006 |
Bailey SI, Howe SJ, Schambach A, Kinnon C, Baum C, Thrasher AJ. 665. Novel Gammaretroviral Vectors for Gene Therapy of SCID-X1 Molecular Therapy. 13. DOI: 10.1016/J.Ymthe.2006.08.742 |
0.412 |
|
| 2006 |
Mackey T, Buddle J, Kinnon C, Thrasher A, Gaspar H, Qasim W. 929. Functional Potential of Human T Cells Following Lentiviral Suicide Gene Transduction Molecular Therapy. 13. DOI: 10.1016/J.Ymthe.2006.08.1020 |
0.432 |
|
| 2005 |
de Noronha S, Hardy S, Sinclair J, Blundell MP, Strid J, Schulz O, Zwirner J, Jones GE, Katz DR, Kinnon C, Thrasher AJ. Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein. Blood. 105: 1590-7. PMID 15494425 DOI: 10.1182/Blood-2004-06-2332 |
0.351 |
|
| 2005 |
Yáñez-Muñoz RJ, Balaggan KS, MacNeil A, Smith AJ, Buch P, Howe S, Durán Y, MacLaren RE, Anderson PN, Kinnon C, Ali RR, Thrasher AJ. 391. Effective Gene Therapy with Non-Integrating Lentivirus Vectors Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.394 |
0.386 |
|
| 2005 |
Gaspar HB, Bjorkegren E, Parsley K, Gilmour KC, Sinclair J, Zhang F, Fairbanks LD, King D, Davies G, Veys PA, Kinnon C, Thrasher AJ. Somatic Gene Therapy for ADA-SCID following cessation of PEG-ADA and use of a mild conditioning regime Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.041 |
0.439 |
|
| 2004 |
Gaspar HB, Parsley KL, Howe S, King D, Gilmour KC, Sinclair J, Brouns G, Schmidt M, Von Kalle C, Barington T, Jakobsen MA, Christensen HO, Al Ghonaium A, White HN, Smith JL, ... ... Kinnon C, et al. Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector. Lancet (London, England). 364: 2181-7. PMID 15610804 DOI: 10.1016/S0140-6736(04)17590-9 |
0.427 |
|
| 2004 |
Schwickerath O, Brouns G, Thrasher A, Kinnon C, Roes J, Casimir C. Enhancer-deleted retroviral vectors restore high levels of superoxide generation in a mouse model of CGD. The Journal of Gene Medicine. 6: 603-15. PMID 15170731 DOI: 10.1002/Jgm.557 |
0.349 |
|
| 2004 |
Sharifi R, Sinclair JC, Gilmour KC, Arkwright PD, Kinnon C, Thrasher AJ, Gaspar HB. SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative disease Blood. 103: 3821-3827. PMID 14726378 DOI: 10.1182/Blood-2003-09-3359 |
0.418 |
|
| 2003 |
Qasim W, King D, Buddle J, Verfuerth S, Kinnon C, Thrasher AJ, Gaspar HB. The impact of retroviral suicide gene transduction procedures on T cells British Journal of Haematology. 123: 712-719. PMID 14616977 DOI: 10.1046/J.1365-2141.2003.04672.X |
0.415 |
|
| 2003 |
Uduehi A, Mailhos C, Truman H, Thrasher AJ, Kinnon C, Hart SL. Enhancement of integrin-mediated transfection of haematopoietic cells with a synthetic vector system. Biotechnology and Applied Biochemistry. 38: 201-9. PMID 12812522 DOI: 10.1042/Ba20030062 |
0.382 |
|
| 2003 |
Siapati KE, Barker S, Kinnon C, Michalski A, Anderson R, Brickell P, Thrasher AJ, Hart SL. Improved antitumour immunity in murine neuroblastoma using a combination of IL-2 and IL-12. British Journal of Cancer. 88: 1641-8. PMID 12771934 DOI: 10.1038/Sj.Bjc.6600928 |
0.312 |
|
| 2002 |
Qasim W, Thrasher AJ, Buddle J, Kinnon C, Black ME, Gaspar HB. T cell transduction and suicide with an enhanced mutant thymidine kinase Gene Therapy. 9: 824-827. PMID 12040465 DOI: 10.1038/Sj.Gt.3301690 |
0.373 |
|
| 2002 |
Demaison C, Parsley K, Brouns G, Scherr M, Battmer K, Kinnon C, Grez M, Thrasher AJ. High-level transduction and gene expression in hematopoietic repopulating cells using a human imunodeficiency virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter Human Gene Therapy. 13: 803-813. PMID 11975847 DOI: 10.1089/10430340252898984 |
0.404 |
|
| 2002 |
Yong KL, Fahey A, Pahal G, Linch DC, Pizzey A, Thomas NS, Jauniaux E, Kinnon C, Thrasher AJ. Fetal haemopoietic cells display enhanced migration across endothelium. British Journal of Haematology. 116: 392-400. PMID 11841444 DOI: 10.1046/J.1365-2141.2002.03273.X |
0.333 |
|
| 2001 |
Estruch EJ, Hart SL, Kinnon C, Winchester BG. Non-viral, integrin-mediated gene transfer into fibroblasts from patients with lysosomal storage diseases. The Journal of Gene Medicine. 3: 488-97. PMID 11601762 DOI: 10.1002/Jgm.214 |
0.327 |
|
| 2001 |
Gilmour KC, Fujii H, Cranston T, Davies EG, Kinnon C, Gaspar HB. Defective expression of the interleukin-2/interleukin-15 receptor beta subunit leads to a natural killer cell-deficient form of severe combined immunodeficiency. Blood. 98: 877-879. PMID 11468191 DOI: 10.1182/Blood.V98.3.877 |
0.338 |
|
| 2001 |
Qasim W, Gilmour KC, Heath S, Ashton E, Cranston T, Thomas A, Finn A, Davies EG, Thrasher AJ, Kinnon C, Jones A, Gaspar HB. Protein assays for diagnosis of Wiskott-Aldrich syndrome and X-linked thrombocytopenia. British Journal of Haematology. 113: 861-5. PMID 11442475 DOI: 10.1046/J.1365-2141.2001.02832.X |
0.371 |
|
| 2001 |
Leverrier Y, Lorenzi R, Blundell MP, Brickell P, Kinnon C, Ridley AJ, Thrasher AJ. Cutting edge: The Wiskott-Aldrich syndrome protein is required for efficient phagocytosis of apoptotic cells Journal of Immunology. 166: 4831-4834. PMID 11290758 DOI: 10.4049/Jimmunol.166.8.4831 |
0.368 |
|
| 2001 |
Gilmour KC, Cranston T, Loughlin S, Gwyther J, Lester T, Espanol T, Hernandez M, Savoldi G, Davies EG, Abinun M, Kinnon C, Jones A, Gaspar HB. Rapid protein-based assays for the diagnosis of T-B+ severe combined immunodeficiency. British Journal of Haematology. 112: 671-6. PMID 11260071 DOI: 10.1046/J.1365-2141.2001.02578.X |
0.411 |
|
| 2001 |
Gaspar HB, Kinnon C. X-Linked Agammaglobulinemia Immunology and Allergy Clinics of North America. 21: 23-43. DOI: 10.1016/S0889-8561(05)70191-0 |
0.392 |
|
| 2000 |
Pahal GS, Jauniaux E, Kinnon C, Thrasher AJ, Rodeck CH. Normal development of human fetal hematopoiesis between eight and seventeen weeks' gestation American Journal of Obstetrics and Gynecology. 183: 1029-1034. PMID 11035358 DOI: 10.1067/Mob.2000.106976 |
0.305 |
|
| 2000 |
Gilmour KC, Cranston T, Jones A, Graham Davies E, Goldblatt D, Thrasher A, Kinnon C, Nichols KE, Caspar HB. Diagnosis of X-linked lymphoproliferative disease by analysis of SLAM-associated protein expression European Journal of Immunology. 30: 1691-1697. PMID 10898506 DOI: 10.1002/1521-4141(200006)30:6<1691::Aid-Immu1691>3.0.Co;2-K |
0.372 |
|
| 2000 |
Ali RR, Sarra GM, Stephens C, Alwis MD, Bainbridge JW, Munro PM, Fauser S, Reichel MB, Kinnon C, Hunt DM, Bhattacharya SS, Thrasher AJ. Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy. Nature Genetics. 25: 306-10. PMID 10888879 DOI: 10.1038/77068 |
0.332 |
|
| 2000 |
Gaspar HB, Ferrando M, Caragol I, Hernandez M, Bertran JM, gracia XD, Lester T, Kinnon C, Ashton E, Espanol T. Kinase mutant Btk results in atypical X-linked agammaglobulinaemia phenotype Clinical and Experimental Immunology. 120: 346-350. PMID 10792386 DOI: 10.1046/J.1365-2249.2000.01230.X |
0.337 |
|
| 2000 |
Thrasher AJ, Kinnon C. The Wiskott-Aldrich syndrome. Clinical and Experimental Immunology. 120: 2-9. PMID 10759756 DOI: 10.1046/J.1365-2249.2000.01193.X |
0.334 |
|
| 2000 |
White H, Thrasher A, Veys P, Kinnon C, Gaspar HB. Intrinsic defects of B cell function in X-linked severe combined immunodeficiency. European Journal of Immunology. 30: 732-737. PMID 10741387 DOI: 10.1002/1521-4141(200003)30:3<732::Aid-Immu732>3.0.Co;2-L |
0.411 |
|
| 2000 |
Jenkins RG, Herrick SE, Meng QH, Kinnon C, Laurent GJ, McAnulty RJ, Hart SL. An integrin-targeted non-viral vector for pulmonary gene therapy. Gene Therapy. 7: 393-400. PMID 10694821 DOI: 10.1038/Sj.Gt.3301095 |
0.379 |
|
| 2000 |
Demaison C, Brouns G, Blundell MP, Goldman JP, Levinsky RJ, Grez M, Kinnon C, Thrasher AJ. A defined window for efficient gene marking of severe combined immunodeficient-repopulating cells using a gibbon ape leukemia virus- pseudotyped retroviral vector Human Gene Therapy. 11: 91-100. PMID 10646642 DOI: 10.1089/10430340050016184 |
0.422 |
|
| 2000 |
Marshall CJ, Kinnon C, Thrasher AJ. Polarized expression of bone morphogenetic protein-4 in the human aorta-gonad-mesonephros region Blood. 96: 1591-1593. DOI: 10.1182/Blood.V96.4.1591.H8001591_1591_1593 |
0.324 |
|
| 2000 |
Lorenzi R, Brickell PM, Katz DR, Kinnon C, Thrasher AJ. Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis Blood. 95: 2943-2946. DOI: 10.1182/Blood.V95.9.2943.009K17_2943_2946 |
0.329 |
|
| 1999 |
Zhang X, De Alwis M, Hart SL, Fitzke FW, Inglis SC, Boursnell ME, Levinsky RJ, Kinnon C, Ali RR, Thrasher AJ. High-titer recombinant adeno-associated virus production from replicating amplicons and herpes vectors deleted for glycoprotein H. Human Gene Therapy. 10: 2527-37. PMID 10543617 DOI: 10.1089/10430349950016861 |
0.32 |
|
| 1999 |
Marshall CJ, Moore RL, Thorogood P, Brickell PM, Kinnon C, Thrasher AJ. Detailed characterization of the human aorta-gonad-mesonephros region reveals morphological polarity resembling a hematopoietic stromal layer. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 215: 139-47. PMID 10373018 DOI: 10.1002/(Sici)1097-0177(199906)215:2<139::Aid-Dvdy6>3.0.Co;2-# |
0.348 |
|
| 1999 |
O'Sullivan E, Kinnon C, Brickell P. Wiskott-Aldrich syndrome protein, WASP. The International Journal of Biochemistry & Cell Biology. 31: 383-387. PMID 10224664 DOI: 10.1016/S1357-2725(98)00118-6 |
0.426 |
|
| 1998 |
Goldman JP, Blundell MP, Lopes L, Kinnon C, Di Santo JP, Thrasher AJ. Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor γ chain British Journal of Haematology. 103: 335-342. PMID 9827902 DOI: 10.1046/J.1365-2141.1998.00980.X |
0.374 |
|
| 1998 |
Binks M, Jones GE, Brickell PM, Kinnon C, Katz DR, Thrasher AJ. Intrinsic dendritic cell abnormalities in Wiskott-Aldrich syndrome European Journal of Immunology. 28: 3259-3267. PMID 9808195 DOI: 10.1002/(Sici)1521-4141(199810)28:10<3259::Aid-Immu3259>3.0.Co;2-B |
0.341 |
|
| 1998 |
MacCarthy-Morrogh L, Gaspar HB, Wang Y, Katz F, Thompson L, Layton M, Jones AM, Kinnon C. Absence of expression of the Wiskott-Aldrich syndrome protein in peripheral blood cells of Wiskott-Aldrich syndrome patients. Clinical Immunology and Immunopathology. 88: 22-27. PMID 9683546 DOI: 10.1006/Clin.1998.4557 |
0.348 |
|
| 1998 |
Zicha D, Allen WE, Brickell PM, Kinnon C, Dunn GA, Jones GE, Thrasher AJ. Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome. British Journal of Haematology. 101: 659-65. PMID 9674738 DOI: 10.1046/J.1365-2141.1998.00767.X |
0.348 |
|
| 1998 |
Ali RR, Reichel MB, De Alwis M, Kanuga N, Kinnon C, Levinsky RJ, Hunt DM, Bhattacharya SS, Thrasher AJ. Adeno-associated virus gene transfer to mouse retina. Human Gene Therapy. 9: 81-6. PMID 9458245 DOI: 10.1089/Hum.1998.9.1-81 |
0.337 |
|
| 1998 |
Goldman JP, Blundell MP, Kinnon C, DiSanto JP, Thrasher AJ. Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain Molecular Immunology. 35: 779. DOI: 10.1016/S0161-5890(98)90488-6 |
0.306 |
|
| 1997 |
Maas A, Dingjan GM, Savelkoul HF, Kinnon C, Grosveld F, Hendriks RW. The X-linked immunodeficiency defect in the mouse is corrected by expression of human Bruton's tyrosine kinase from a yeast artificial chromosome transgene. European Journal of Immunology. 27: 2180-7. PMID 9341757 DOI: 10.1002/Eji.1830270910 |
0.408 |
|
| 1997 |
Thrasher AJ, Goldman J, de Alwis M, Porter CD, Kinnon C. Gene therapy for primary immunodeficiency. Biochemical Society Transactions. 25: 537-40. PMID 9191151 DOI: 10.1042/Bst0250537 |
0.325 |
|
| 1997 |
Jones AM, Clark PA, Katz F, Genet S, McMahon C, Alterman L, Cant A, Kinnon C. B-cell-negative severe combined immunodeficiency associated with a common gamma chain mutation. Human Genetics. 99: 677-680. PMID 9150740 DOI: 10.1007/S004390050428 |
0.437 |
|
| 1996 |
Katz F, Hinshelwood S, Rutland P, Jones A, Kinnon C, Morgan G. Mutation analysis in CD40 ligand deficiency leading to X-linked hypogammaglobulinemia with hyper IgM syndrome. Human Mutation. 8: 223-228. PMID 8889581 DOI: 10.1002/(Sici)1098-1004(1996)8:3<223::Aid-Humu5>3.0.Co;2-A |
0.37 |
|
| 1996 |
Jones A, Bradley L, Alterman L, Tarlow M, Thompson R, Kinnon C, Morgan G. X linked agammaglobulinaemia with a 'leaky' phenotype. Archives of Disease in Childhood. 74: 548-549. PMID 8758136 DOI: 10.1136/Adc.74.6.548 |
0.438 |
|
| 1996 |
Ali RR, Reichel MB, Thrasher AJ, Levinsky RJ, Kinnon C, Kanuga N, Hunt DM, Bhattacharya SS. Gene transfer into the mouse retina mediated by an adeno-associated viral vector Human Molecular Genetics. 5: 591-594. PMID 8733124 DOI: 10.1093/Hmg/5.5.591 |
0.361 |
|
| 1996 |
Porter CD, Kuribayashi F, Parkar MH, Roos D, Kinnon C. Detection of gp91-phox precursor protein in B-cell lines from patients with X-linked Chronic Granulomatous Disease as an indicator for mutations impairing cytochrome b558 biosynthesis Biochemical Journal. 315: 571-575. PMID 8615831 DOI: 10.1042/Bj3150571 |
0.355 |
|
| 1996 |
Porter CD, Parkar MH, Collins MKL, Levinsky RJ, Kinnon C. Efficient retroviral transduction of human bone marrow progenitor and long-term culture-initiating cells: partial reconstitution of cells from patients with X-linked chronic granulomatous disease by gp91-phox expression Blood. 87: 3722-3730. DOI: 10.1182/Blood.V87.9.3722.Bloodjournal8793722 |
0.449 |
|
| 1996 |
Notarangelo LD, Peitsch MC, Abrahamsen TG, Bachelot C, Bordigoni P, Cant AJ, Chapel H, Clementi M, Deacock S, Basile GdS, Duse M, Espanol T, Etzioni A, Fasth A, Fischer A, ... ... Kinnon C, et al. CD40lbase: a database of CD40L gene mutations causing X-linked hyper-IgM syndrome. Immunology Today. 17: 511-516. DOI: 10.1016/S0167-5699(96)80904-2 |
0.351 |
|
| 1995 |
Hinshelwood S, Lovering RC, Genevier HC, Levinsky RJ, Kinnon C. The protein defective in X-linked agammaglobulinemia, Bruton's tyrosine kinase, shows increased autophosphorylation activity in vitro when isolated from cells in which the B cell receptor has been cross-linked. European Journal of Immunology. 25: 1113-6. PMID 7737282 DOI: 10.1002/Eji.1830250439 |
0.393 |
|
| 1995 |
Gaspar HB, Bradley LA, Katz F, Lovering RC, Roifman CM, Morgan G, Levinsky RJ, Kinnon C. Mutation analysis in Bruton's tyrosine kinase, the X-linked agammaglobulinaemia gene, including identification of an insertional hotspot. Human Molecular Genetics. 4: 755-7. PMID 7633429 DOI: 10.1093/Hmg/4.4.755 |
0.358 |
|
| 1995 |
Cory GO, Lovering RC, Hinshelwood S, MacCarthy-Morrogh L, Levinsky RJ, Kinnon C. The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase. The Journal of Experimental Medicine. 182: 611-5. PMID 7629518 DOI: 10.1084/Jem.182.2.611 |
0.359 |
|
| 1995 |
Clark PA, Lester T, Genet S, Jones AM, Hendriks R, Levinsky RJ, Kinnon C. Screening for mutations causing X-linked severe combined immunodeficiency in the IL-2R gamma chain gene by single-strand conformation polymorphism analysis. Human Genetics. 96: 427-432. PMID 7557965 DOI: 10.1007/Bf00191801 |
0.313 |
|
| 1995 |
Thrasher AJ, Casimir CM, Kinnon C, Morgan G, Levinsky RJ, Segal AW. Gene transfer to primary chronic granulomatous disease monocytes The Lancet. 346: 92-93. PMID 7541496 DOI: 10.1016/S0140-6736(95)92116-8 |
0.393 |
|
| 1995 |
Thrasher AJ, Alwis MD, Casimir CM, Kinnon C, Page K, Lebkowski J, Segal AW, Levinsky RJ. Functional Reconstitution of the NADPH-Oxidase by Adeno-Associated Virus Gene Transfer Blood. 86: 761-765. DOI: 10.1182/Blood.V86.2.761.Bloodjournal862761 |
0.44 |
|
| 1994 |
Parkar M, Lovering R, Levinsky RJ, Kinnon C. Genetic mapping of two loci, DXS454 and DXS458, with respect to the X-linked agammaglobulinemia gene locus. Human Genetics. 93: 89-90. PMID 8270264 DOI: 10.1007/Bf00218924 |
0.301 |
|
| 1994 |
Bradley LA, Sweatman AK, Lovering RC, Jones AM, Morgan G, Levinsky RJ, Kinnon C. Mutation detection in the X-linked agammaglobulinemia gene, BTK, using single strand conformation polymorphism analysis. Human Molecular Genetics. 3: 79-83. PMID 8162056 DOI: 10.1093/Hmg/3.1.79 |
0.389 |
|
| 1994 |
Sweatman AK, Bradley LA, Lovering RC, O'Reilly MA, Levinsky RJ, Kinnon C. Physical mapping in the region of the Bruton's tyrosine kinase and alpha-galactosidase A gene loci in proximal Xq22. Human Genetics. 94: 624-8. PMID 7989038 DOI: 10.1007/Bf00206955 |
0.302 |
|
| 1994 |
Lester T, de Alwis M, Clark PA, Jones AM, Katz F, Levinsky RJ, Kinnon C. Trisomy X in a female member of a family with X linked severe combined immunodeficiency: implications for carrier diagnosis. Journal of Medical Genetics. 31: 717-20. PMID 7815443 DOI: 10.1136/Jmg.31.9.717 |
0.31 |
|
| 1994 |
Genevier HC, Hinshelwood S, Gaspar HB, Rigley KP, Brown D, Saeland S, Rousset F, Levinsky RJ, Callard RE, Kinnon C, Lovering RC. Expression of Bruton's tyrosine kinase protein within the B cell lineage European Journal of Immunology. 24: 3100-3105. PMID 7805739 DOI: 10.1002/Eji.1830241228 |
0.412 |
|
| 1994 |
Porter CD, Parkar MH, Verhoeven AJ, Levinsky RJ, Collins MKL, Kinnon C. p22-phox-Deficient Chronic Granulomatous Disease: Reconstitution by Retrovirus-Mediated Expression and Identification of a Biosynthetic Intermediate of gp91-phox Blood. 84: 2767-2775. DOI: 10.1182/Blood.V84.8.2767.Bloodjournal8482767 |
0.374 |
|
| 1993 |
Lovering R, Middleton-Price HR, O'Reilly MAJ, Genet SA, Parkar M, Sweatman AK, Bradley LD, Alterman LA, Malcolm S, Morgan G, Levinsky RJ, Kinnon C. Genetic linkage analysis identifies new proximal and distal flanking markers for the X-linked agammaglobulinemia gene locus, refining its localization in Xq22 Human Molecular Genetics. 2: 139-141. PMID 8499902 DOI: 10.1093/Hmg/2.2.139 |
0.382 |
|
| 1993 |
Lovering R, Sweatman AK, O'reilly M-J, Genet SA, Middleton-Price H, Malcolm S, Levinsky RJ, Kinnon C. Physical mapping identifies DXS265 as a useful genetic marker for carrier detection and prenatal diagnosis of X-linked agammaglobulinemia Human Genetics. 91: 178-180. PMID 8462977 DOI: 10.1007/Bf00222721 |
0.322 |
|
| 1993 |
O'Reilly MJ, Alterman LA, Zijlstra J, Malcolm S, Levinsky RJ, Kinnon C. Pulsed-Field Gel Electrophoresis and Radiation Hybrid Mapping Analyses Enable the Ordering of Eleven DNA Loci in Xq22 Genomics. 15: 275-282. PMID 8449491 DOI: 10.1006/Geno.1993.1057 |
0.307 |
|
| 1993 |
Vetrie D, Vořechovský I, Sideras P, Holland J, Davies A, Flinter F, Hammarström L, Kinnon C, Levinsky R, Bobrow M, Smith CIE, Bentley DR. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases Nature. 361: 226-233. PMID 8380905 DOI: 10.1038/361226A0 |
0.439 |
|
| 1993 |
Jones AM, Malcolm S, Levinsky RJ, Kinnon C. Physical mapping in the region of human Xq12-21.1 using pulsed field gel electrophoresis. Human Genetics. 91: 485-488. PMID 8314562 DOI: 10.1007/Bf00217777 |
0.302 |
|
| 1993 |
Kinnon C, Hinshelwood S, Levinsky RJ, Lovering RC. X-linked agammaglobulinemia--gene cloning and future prospects. Immunology Today. 14: 554-8. PMID 8274198 DOI: 10.1016/0167-5699(93)90187-P |
0.429 |
|
| 1993 |
Alterman LA, de Alwis M, Genet S, Lovering R, Middleton-Price H, Morgan G, Jones A, Malcolm S, Levinsky RJ, Kinnon C. Carrier determination for X-linked agammaglobulinemia using X inactivation analysis of purified B cells. Journal of Immunological Methods. 166: 111-6. PMID 8228281 DOI: 10.1016/0022-1759(93)90334-4 |
0.352 |
|
| 1993 |
O'Reilly MA, Sweatman AK, Bradley LD, Alterman LA, Lovering R, Malcolm S, Levinsky RJ, Kinnon C. Isolation and mapping of discrete DXS101 loci in Xq22 near the X-linked agammaglobulinaemia gene locus. Human Genetics. 91: 605-8. PMID 8101833 DOI: 10.1007/Bf00205088 |
0.329 |
|
| 1993 |
Sweatman A, Lovering R, Middleton-Price H, Jones A, Morgan G, Levinsky R, Kinnon C. A new restriction fragment length polymorphism at the DXS101 locus allows carrier detection in a family with X linked agammaglobulinaemia Journal of Medical Genetics. 30: 512-514. PMID 8100857 DOI: 10.1136/Jmg.30.6.512 |
0.315 |
|
| 1993 |
Padayachee M, Levinsky RJ, Kinnon C, Finn A, McKeown C, Feighery C, Notarangelo LD, Hendriks RW, Read AP, Malcolm S. Mapping of the X linked form of hyper IgM syndrome (HIGM1) Journal of Medical Genetics. 30: 202-5. PMID 8097258 DOI: 10.1136/Jmg.30.3.202 |
0.377 |
|
| 1993 |
Porter CD, Parkar MH, Levinsky RJ, Collins MKL, Kinnon C. X-Linked Chronic Granulomatous Disease: Correction of NADPH Oxidase Defect by Retrovirus-Mediated Expression of gp91-phox Blood. 82: 2196-2202. DOI: 10.1182/Blood.V82.7.2196.Bloodjournal8272196 |
0.419 |
|
| 1992 |
Kinnon C, Levinsky R. The molecular basis of X-linked immunodeficiency disease Journal of Inherited Metabolic Disease. 15: 674-682. PMID 1528025 DOI: 10.1007/Bf01799623 |
0.372 |
|
| 1992 |
O'Reilly MJ, Alterman LA, Malcolm S, Levinsky RJ, Kinnon C. Identification of CpG islands around the DXS178 locus in the region of the X-linked agammaglobulinaemia gene locus in Xq22. Human Genetics. 90: 275-278. PMID 1487242 DOI: 10.1007/Bf00220078 |
0.345 |
|
| 1992 |
Porter CD, Parkar MH, Collins MKL, Levinsky RJ, Kinnon C. Superoxide production by normal and chronic granulomatous disease (CGD) patient-derived EBV-transformed B cell lines measured by chemiluminescence-based assays Journal of Immunological Methods. 155: 151-157. PMID 1331241 DOI: 10.1016/0022-1759(92)90281-W |
0.343 |
|
| 1991 |
Rougon G, Alterman LA, Dennis K, Guo XJ, Kinnon C. The murine heat-stable antigen: a differentiation antigen expressed in both the hematolymphoid and neural cell lineages. European Journal of Immunology. 21: 1397-402. PMID 2044653 DOI: 10.1002/Eji.1830210611 |
0.303 |
|
| 1990 |
Kinnon C, Levinsky RJ. Somatic gene therapy for genetic disease. Archives of Disease in Childhood. 65: 72-73. PMID 2405788 DOI: 10.1136/Adc.65.1.72 |
0.334 |
|
| 1990 |
Kinnon C, Levinsky RJ. Gene therapy for cancer. European Journal of Cancer and Clinical Oncology. 26: 638-640. PMID 2169279 DOI: 10.1016/0277-5379(90)90096-C |
0.387 |
|
| 1990 |
O'Reilly MJ, Kinnon C. The technique of pulsed field gel electrophoresis and its impact on molecular immunology. Journal of Immunological Methods. 131: 1-13. PMID 2116481 DOI: 10.1016/0022-1759(90)90226-L |
0.313 |
|
| 1990 |
Pelham A, O'reilly M-J, Malcolm S, Levinsky RJ, Kinnon C. RFLP and deletion analysis for X-linked chronic granulomatous disease using the cDNA probe: potential for improved prenatal diagnosis and carrier determination. Blood. 76: 820-824. DOI: 10.1182/Blood.V76.4.820.Bloodjournal764820 |
0.342 |
|
| 1990 |
Pelham A, Kinnon C, Levinsky RJ. Prenatal diagnosis and carrier detection of inherited immunodeficiency disorders Pediatric Allergy and Immunology. 1: 51-59. DOI: 10.1111/J.1399-3038.1990.Tb00010.X |
0.331 |
|
| 1987 |
Kinnon C, McGuire KL, Rothenberg EV. Differential regulation of T cell receptor gamma genes in immature thymocyte populations European Journal of Immunology. 17: 1265-1269. PMID 2958294 DOI: 10.1002/Eji.1830170908 |
0.692 |
|
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