| Year |
Citation |
Score |
| 2022 |
Elkamhawy A, Paik S, Ali EMH, Hassan AHE, Kang SJ, Lee K, Roh EJ. Identification of Novel Aryl Carboxamide Derivatives as Death-Associated Protein Kinase 1 (DAPK1) Inhibitors with Anti-Proliferative Activities: Design, Synthesis, In Vitro, and In Silico Biological Studies. Pharmaceuticals (Basel, Switzerland). 15. PMID 36145271 DOI: 10.3390/ph15091050 |
0.62 |
|
| 2022 |
Jacobson KA, Kim HS, Ravi G, Kim SK, Lee K, Chen A, Chen W, Kim SG, Barak D, Liang BT, Gao ZG. Engineering of A Adenosine and P2Y Nucleotide Receptors and Their Ligands. Drug Development Research. 58: 330-339. PMID 35799977 DOI: 10.1002/ddr.10168 |
0.762 |
|
| 2022 |
Nada H, Lee K, Gotina L, Pae AN, Elkamhawy A. Identification of novel discoidin domain receptor 1 (DDR1) inhibitors using E-pharmacophore modeling, structure-based virtual screening, molecular dynamics simulation and MM-GBSA approaches. Computers in Biology and Medicine. 142: 105217. PMID 35032738 DOI: 10.1016/j.compbiomed.2022.105217 |
0.319 |
|
| 2021 |
Lee K, Nada H, Byun HJ, Lee CH, Elkamhawy A. Hit Identification of a Novel Quinazoline Sulfonamide as a Promising EphB3 Inhibitor: Design, Virtual Combinatorial Library, Synthesis, Biological Evaluation, and Docking Simulation Studies. Pharmaceuticals (Basel, Switzerland). 14. PMID 34959648 DOI: 10.3390/ph14121247 |
0.327 |
|
| 2021 |
Elsherbeny MH, Kim J, Gouda NA, Gotina L, Cho J, Pae AN, Lee K, Park KD, Elkamhawy A, Roh EJ. Highly Potent, Selective, and Competitive Indole-Based MAO-B Inhibitors Protect PC12 Cells against 6-Hydroxydopamine- and Rotenone-Induced Oxidative Stress. Antioxidants (Basel, Switzerland). 10. PMID 34679775 DOI: 10.3390/antiox10101641 |
0.618 |
|
| 2021 |
Elkamhawy A, Woo J, Gouda NA, Kim J, Nada H, Roh EJ, Park KD, Cho J, Lee K. Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress. Antioxidants (Basel, Switzerland). 10. PMID 34679739 DOI: 10.3390/antiox10101604 |
0.605 |
|
| 2021 |
Elsherbeny MH, Elkamhawy A, Nada H, Abdellattif MH, Lee K, Roh EJ. Development of New Meridianin/Leucettine-Derived Hybrid Small Molecules as Nanomolar Multi-Kinase Inhibitors with Antitumor Activity. Biomedicines. 9. PMID 34572319 DOI: 10.3390/biomedicines9091131 |
0.615 |
|
| 2021 |
Elkamhawy A, Kim HJ, Elsherbeny MH, Paik S, Park JH, Gotina L, Abdellattif MH, Gouda NA, Cho J, Lee K, Nim Pae A, Park KD, Roh EJ. Discovery of 3,4-dichloro-N-(1H-indol-5-yl)benzamide: A highly potent, selective, and competitive hMAO-B inhibitor with high BBB permeability profile and neuroprotective action. Bioorganic Chemistry. 116: 105352. PMID 34562673 DOI: 10.1016/j.bioorg.2021.105352 |
0.628 |
|
| 2021 |
Elkamhawy A, Ammar UM, Paik S, Abdellattif MH, Elsherbeny MH, Lee K, Roh EJ. Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening. Molecules (Basel, Switzerland). 26. PMID 34500757 DOI: 10.3390/molecules26175324 |
0.638 |
|
| 2021 |
Elkamhawy A, Paik S, Park JH, Kim HJ, Hassan AHE, Lee K, Park KD, Roh EJ. Discovery of novel and potent safinamide-based derivatives as highly selective hMAO-B inhibitors for treatment of Parkinson's disease (PD): Design, synthesis, in vitro, in vivo and in silico biological studies. Bioorganic Chemistry. 115: 105233. PMID 34390968 DOI: 10.1016/j.bioorg.2021.105233 |
0.628 |
|
| 2020 |
Kim M, Wei JD, Harmalkar DS, Goo JI, Lee K, Choi Y, Kim JH, Cho AE. Elucidation of Mechanism for Ligand Efficacy at Leukotriene B Receptor 2 (BLT2). Acs Medicinal Chemistry Letters. 11: 1529-1534. PMID 32832019 DOI: 10.1021/Acsmedchemlett.0C00065 |
0.358 |
|
| 2020 |
Elkamhawy A, Paik S, Kim HJ, Park JH, Londhe AM, Lee K, Pae AN, Park KD, Roh EJ. Discovery of -(1-(3-fluorobenzoyl)-1-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B. Journal of Enzyme Inhibition and Medicinal Chemistry. 35: 1568-1580. PMID 32752896 DOI: 10.1080/14756366.2020.1800666 |
0.654 |
|
| 2020 |
Al-Sanea MM, Elkamhawy A, Paik S, Lee K, El Kerdawy AM, Syed Nasir Abbas B, Joo Roh E, Eldehna WM, Elshemy HAH, Bakr RB, Ali Farahat I, Alzarea AI, Alzarea SI, Alharbi KS, Abdelgawad MA. Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights. Bioorganic & Medicinal Chemistry. 115525. PMID 32371117 DOI: 10.1016/J.Bmc.2020.115525 |
0.389 |
|
| 2020 |
Sivaraman A, Kim DG, Bhattarai D, Kim M, Lee HY, Lim S, Kong J, Goo JI, Shim S, Lee S, Suh YG, Choi Y, Kim S, Lee K. Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy. Journal of Medicinal Chemistry. PMID 32315177 DOI: 10.1021/Acs.Jmedchem.9B01961 |
0.376 |
|
| 2019 |
Lu Q, Harmalkar DS, Choi Y, Lee K. An Overview of Saturated Cyclic Ethers: Biological Profiles and Synthetic Strategies. Molecules (Basel, Switzerland). 24. PMID 31640154 DOI: 10.3390/Molecules24203778 |
0.301 |
|
| 2019 |
Harmalkar DS, Lee SJ, Lu Q, Kim MI, Park J, Lee H, Park M, Lee A, Lee C, Lee K. Identification of novel non-nucleoside vinyl-stilbene analogs as potent norovirus replication inhibitors with a potential host-targeting mechanism. European Journal of Medicinal Chemistry. 184: 111733. PMID 31604163 DOI: 10.1016/J.Ejmech.2019.111733 |
0.382 |
|
| 2019 |
Soung NK, Kim HM, Asami Y, Kim DH, Cho Y, Naik R, Jang Y, Jang K, Han HJ, Ganipisetti SR, Cha-Molstad H, Hwang J, Lee KH, Ko SK, Jang JH, ... ... Lee KS, ... ... Lee K, et al. Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition. Experimental & Molecular Medicine. 51: 10. PMID 30755586 DOI: 10.1038/S12276-018-0200-4 |
0.313 |
|
| 2018 |
Harmalkar DS, Lu Q, Lee K. Total Synthesis of Gramistilbenoids A, B, and C. Journal of Natural Products. PMID 29613790 DOI: 10.1021/Acs.Jnatprod.7B00865 |
0.336 |
|
| 2018 |
Harmalkar DS, Mali JR, Sivaraman A, Choi Y, Lee K. Schweinfurthins A–Q: isolation, synthesis, and biochemical properties Rsc Advances. 8: 21191-21209. DOI: 10.1039/C8Ra02872A |
0.337 |
|
| 2017 |
Bhattarai D, Xu X, Lee K. Hypoxia-inducible factor-1 (HIF-1) inhibitors from the last decade (2007 to 2016): A "structure-activity relationship" perspective. Medicinal Research Reviews. PMID 29278273 DOI: 10.1002/Med.21477 |
0.329 |
|
| 2017 |
Naik R, Ban HS, Jang K, Kim I, Xu X, Harmalkar D, Shin SA, Kim M, Kim BK, Park J, Ku B, Oh S, Won M, Lee K. Methyl 3-(3-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism. Journal of Medicinal Chemistry. PMID 28991459 DOI: 10.1021/Acs.Jmedchem.7B01231 |
0.391 |
|
| 2017 |
Ban HS, Kim BK, Lee H, Kim HM, Harmalkar D, Nam M, Park SK, Lee K, Park JT, Kim I, Lee K, Hwang GS, Won M. The novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth. Cell Death & Disease. 8: e2843. PMID 28569777 DOI: 10.1038/Cddis.2017.235 |
0.331 |
|
| 2017 |
Singh S, Goo JI, Noh H, Lee SJ, Kim MW, Park H, Jalani HB, Lee K, Kim C, Kim WK, Ju C, Choi Y. Discovery of a novel series of N-hydroxypyridone derivatives protecting astrocytes against hydrogen peroxide-induced toxicity via improved mitochondrial functionality. Bioorganic & Medicinal Chemistry. PMID 28089588 DOI: 10.1016/J.Bmc.2016.12.052 |
0.302 |
|
| 2017 |
Won M, Ban HS, Lee K, Lee H, Kim B, Kim HM, Naik R, Park S, Park J, Kim I, Nam M, Hwang G. Abstract 1164: A novel hypoxia-inducible factor-1 inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth Cancer Research. 77: 1164-1164. DOI: 10.1158/1538-7445.Am2017-1164 |
0.307 |
|
| 2016 |
Bhattarai D, Jung JH, Han S, Lee H, Oh SJ, Ko HW, Lee K. Design, synthesis, and biological evaluation of structurally modified isoindolinone and quinazolinone derivatives as hedgehog pathway inhibitors. European Journal of Medicinal Chemistry. 125: 1036-1050. PMID 27810591 DOI: 10.1016/J.Ejmech.2016.10.040 |
0.368 |
|
| 2016 |
Lee SJ, Jung YS, Yoon MH, Kang SM, Oh AY, Lee JH, Jun SY, Woo TG, Chun HY, Kim SK, Chung KJ, Lee HY, Lee K, Kim G, Na MK, et al. Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype. The Journal of Clinical Investigation. PMID 27617860 DOI: 10.1172/Jci84164 |
0.306 |
|
| 2016 |
Ban HS, Xu X, Jang K, Kim I, Kim BK, Lee K, Won M. A Novel Malate Dehydrogenase 2 Inhibitor Suppresses Hypoxia-Inducible Factor-1 by Regulating Mitochondrial Respiration. Plos One. 11: e0162568. PMID 27611801 DOI: 10.1371/Journal.Pone.0162568 |
0.386 |
|
| 2016 |
Ban HS, Naik R, Kim HM, Kim BK, Lee H, Kim I, Ahn HC, Jang Y, Jang K, Eo Y, Song KB, Lee K, Won M. Identification of targets of the HIF-1 inhibitor IDF-11774 using alkyne-conjugated photoaffinity probes. Bioconjugate Chemistry. PMID 27386732 DOI: 10.1021/Acs.Bioconjchem.6B00305 |
0.34 |
|
| 2016 |
Jung SW, Lee K, Cho AE. Computational approaches to predict binding interactions between mammalian tyrosinases and (S)-(+)-decursin and its analogues as potent inhibitors Rsc Advances. 6: 46765-46774. DOI: 10.1039/C6Ra09365E |
0.372 |
|
| 2015 |
Liu Y, Park JM, Chang KH, Huh HJ, Lee K, Lee MY. AMP-activated Protein Kinase Mediates the Antiplatelet Effects of the Thiazolidinediones Rosiglitazone and Pioglitazone. Molecular Pharmacology. PMID 26643379 DOI: 10.1124/Mol.115.102004 |
0.305 |
|
| 2015 |
Kim HJ, Fei X, Cho SC, Choi BY, Ahn HC, Lee K, Seo SY, Keum YS. Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1. Bioorganic & Medicinal Chemistry Letters. PMID 26508549 DOI: 10.1016/J.Bmcl.2015.10.034 |
0.303 |
|
| 2015 |
Singh S, Goo J, Gajulapati V, Chang TS, Lee K, Choi Y. Recent Advances in Anticancer Chemotherapeutics based upon Azepine Scaffold. Anti-Cancer Agents in Medicinal Chemistry. PMID 26373395 DOI: 10.2174/1871520615666150916091750 |
0.311 |
|
| 2015 |
Naik R, Han S, Lee K. Chemical biology approach for the development of hypoxia inducible factor (HIF) inhibitor LW6 as a potential anticancer agent. Archives of Pharmacal Research. 38: 1563-74. PMID 26310207 DOI: 10.1007/S12272-015-0632-5 |
0.328 |
|
| 2015 |
Kim BS, Lee K, Jung HJ, Bhattarai D, Kwon HJ. HIF-1α suppressing small molecule, LW6, inhibits cancer cell growth by binding to calcineurin b homologous protein 1. Biochemical and Biophysical Research Communications. 458: 14-20. PMID 25603055 DOI: 10.1016/J.Bbrc.2015.01.031 |
0.339 |
|
| 2015 |
Kim M, Kwon J, Kim MO, Singh S, Kim SK, Lee K, Lee K, Lee HS, Choi Y. Discovery of a Novel Series of Indolyl Hydrazide Derivatives as Diacylglycerol Acyltransferase-1 Inhibitors Bulletin of the Korean Chemical Society. 36: 628-635. DOI: 10.1002/Bkcs.10123 |
0.368 |
|
| 2015 |
Son S, Kim D, Lee S, Jin G, Park J, Han H, Lee K, Lee C. Synthesis and Structure-Activity Relationship of Novel Indole Acrylamide Derivatives as HCV Replication Inhibitors Bulletin of the Korean Chemical Society. 36: 88-98. DOI: 10.1002/Bkcs.10021 |
0.321 |
|
| 2015 |
Singh S, Veeraswamy G, Bhattarai D, Goo JI, Lee K, Choi Y. Recent Advances in the Development of Pharmacologically Active Compounds that Contain a Benzoxazole Scaffold Asian Journal of Organic Chemistry. 4: 1338-1361. DOI: 10.1002/Ajoc.201500235 |
0.34 |
|
| 2014 |
Naik R, Won M, Ban HS, Bhattarai D, Xu X, Eo Y, Hong YS, Singh S, Choi Y, Ahn HC, Lee K. Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1α/malate dehydrogenase 2 inhibitors. Journal of Medicinal Chemistry. 57: 9522-38. PMID 25356789 DOI: 10.1021/Jm501241G |
0.367 |
|
| 2014 |
Jin G, Lee S, Choi M, Son S, Kim GW, Oh JW, Lee C, Lee K. Chemical genetics-based discovery of indole derivatives as HCV NS5B polymerase inhibitors. European Journal of Medicinal Chemistry. 75: 413-25. PMID 24561671 DOI: 10.1016/J.Ejmech.2014.01.062 |
0.317 |
|
| 2013 |
Chung KS, Han G, Kim BK, Kim HM, Yang JS, Ahn J, Lee K, Song KB, Won M. A novel antitumor piperazine alkyl compound causes apoptosis by inducing RhoB expression via ROS‑mediated c‑Abl/p38 MAPK signaling. Cancer Chemotherapy and Pharmacology. 72: 1315-24. PMID 24121479 DOI: 10.1007/S00280-013-2310-Y |
0.334 |
|
| 2013 |
Ju C, Song S, Hwang S, Kim C, Kim M, Gu J, Oh YK, Lee K, Kwon J, Lee K, Kim WK, Choi Y. Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects. Bioorganic & Medicinal Chemistry Letters. 23: 5421-5. PMID 23953190 DOI: 10.1016/J.Bmcl.2013.07.038 |
0.331 |
|
| 2013 |
Lee K, Cho SH, Lee JH, Goo J, Lee SY, Boovanahalli SK, Yeo SK, Lee SJ, Kim YK, Kim DH, Choi Y, Song GY. Synthesis of a novel series of 2-alkylthio substituted naphthoquinones as potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors. European Journal of Medicinal Chemistry. 62: 515-25. PMID 23419736 DOI: 10.1016/J.Ejmech.2013.01.020 |
0.398 |
|
| 2013 |
Song D, Yang JS, Kim SJ, Kim BK, Park SK, Won M, Lee K, Kim HM, Choi KY, Lee K, Han G. Design, synthesis and biological evaluation of novel aliphatic amido/sulfonamido-quaternary ammonium salts as antitumor agents. Bioorganic & Medicinal Chemistry. 21: 788-94. PMID 23266181 DOI: 10.1016/J.Bmc.2012.11.027 |
0.379 |
|
| 2013 |
Lee K, Kim M, Lee B, Goo J, Kim J, Naik R, Seo JH, Kim MO, Byun Y, Song GY, Lee HS, Choi Y. Discovery of indolyl acrylamide derivatives as human diacylglycerol acyltransferase-2 selective inhibitors. Organic & Biomolecular Chemistry. 11: 849-58. PMID 23242135 DOI: 10.1039/C2Ob27114A |
0.387 |
|
| 2013 |
Kwon J, Kondaji G, Song S, Kim C, Lee K, Kim WK, Choi Y. Synthesis of naturally occurring norlignan (±)-nyasol Bulletin of the Korean Chemical Society. 34: 1247-1249. DOI: 10.5012/Bkcs.2013.34.4.1247 |
0.39 |
|
| 2012 |
Naik R, Won M, Kim BK, Xia Y, Choi HK, Jin G, Jung Y, Kim HM, Lee K. Synthesis and structure-activity relationship of (E)-phenoxyacrylic amide derivatives as hypoxia-inducible factor (HIF) 1α inhibitors. Journal of Medicinal Chemistry. 55: 10564-71. PMID 23153200 DOI: 10.1021/Jm301419D |
0.37 |
|
| 2012 |
Lee K, Goo JI, Jung HY, Kim M, Boovanahalli SK, Park HR, Kim MO, Kim DH, Lee HS, Choi Y. Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 7456-60. PMID 23141914 DOI: 10.1016/J.Bmcl.2012.10.046 |
0.324 |
|
| 2012 |
Kim M, Gajulapati K, Kim C, Jung HY, Goo J, Lee K, Kaur N, Kang HJ, Chung SJ, Choi Y. A facile synthetic route to diazepinone derivatives via ring closing metathesis and its application for human cytidine deaminase inhibitors. Chemical Communications (Cambridge, England). 48: 11443-5. PMID 23086289 DOI: 10.1039/C2Cc35484E |
0.345 |
|
| 2012 |
Lee K, Jung SW, Naik R, Cho AE. 3D-QSAR Study of Melanin Inhibiting (S)-(+)-Decursin and its Analogues by Pharmacophore Mapping Bulletin of the Korean Chemical Society. 33: 149-152. DOI: 10.5012/Bkcs.2012.33.1.149 |
0.36 |
|
| 2011 |
Xia Y, Jin Y, Kaur N, Choi Y, Lee K. HIF-1α inhibitors: synthesis and biological evaluation of novel moracin O and P analogues. European Journal of Medicinal Chemistry. 46: 2386-96. PMID 21481991 DOI: 10.1016/J.Ejmech.2011.03.022 |
0.37 |
|
| 2011 |
Kim BK, Kim HM, Chung KS, Kim DM, Park SK, Song A, Won KJ, Lee K, Oh YK, Lee K, Song KB, Simon JA, Han G, Won M. Upregulation of RhoB via c-Jun N-terminal kinase signaling induces apoptosis of the human gastric carcinoma NUGC-3 cells treated with NSC12618. Carcinogenesis. 32: 254-61. PMID 21084431 DOI: 10.1093/Carcin/Bgq244 |
0.339 |
|
| 2011 |
Naik R, Jeon C, Min H, Choi H, Min K, Lee K. Synthesis and Bioactivity of Novel Adamantyl Derivatives as Potent MDR Reversal Agents Bulletin of the Korean Chemical Society. 32: 4444-4446. DOI: 10.5012/Bkcs.2011.32.12.4444 |
0.383 |
|
| 2011 |
Lee K, Roh S, Xia Y, Kang K. Synthesis and Biological Evaluation of Phenoxy-N-phenylacetamide Derivatives as Novel P-glycoprotein Inhibitors Bulletin of the Korean Chemical Society. 32: 3666-3674. DOI: 10.5012/Bkcs.2011.32.10.3666 |
0.4 |
|
| 2010 |
Lee K, Lee JH, Boovanahalli SK, Choi Y, Choo SJ, Yoo ID, Kim DH, Yun MY, Lee GW, Song GY. Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells. European Journal of Medicinal Chemistry. 45: 5567-75. PMID 20884093 DOI: 10.1016/J.Ejmech.2010.09.006 |
0.393 |
|
| 2010 |
Lee K, Kwon OK, Xia Y, Ahn KS. Effect of AC-264, a novel indole derivative, on apoptosis in HL-60 cells Bulletin of the Korean Chemical Society. 31: 3777-3781. DOI: 10.5012/Bkcs.2010.31.12.3777 |
0.304 |
|
| 2009 |
Min KH, Xia Y, Kim EK, Jin Y, Kaur N, Kim ES, Kim DK, Jung HY, Choi Y, Park MK, Min YK, Lee K, Lee K. A novel class of highly potent multidrug resistance reversal agents: disubstituted adamantyl derivatives. Bioorganic & Medicinal Chemistry Letters. 19: 5376-9. PMID 19679475 DOI: 10.1016/J.Bmcl.2009.07.127 |
0.349 |
|
| 2009 |
Won MS, Im N, Park S, Boovanahalli SK, Jin Y, Jin X, Chung KS, Kang M, Lee K, Park SK, Kim HM, Kwon BM, Lee JJ, Lee K. A novel benzimidazole analogue inhibits the hypoxia-inducible factor (HIF)-1 pathway. Biochemical and Biophysical Research Communications. 385: 16-21. PMID 19433063 DOI: 10.1016/J.Bbrc.2009.05.022 |
0.347 |
|
| 2009 |
Chung JY, Pasha FA, Cho SJ, Won M, Lee JJ, Lee K. Pharmacophore-based 3D-QSAR of HIF-1 inhibitors Archives of Pharmacal Research. 32: 317-323. PMID 19387572 DOI: 10.1007/S12272-009-1301-3 |
0.333 |
|
| 2009 |
Kim W, Lee D, Hong SS, Na Z, Shin JC, Roh SH, Wu CZ, Choi O, Lee K, Shen YM, Paik SG, Lee JJ, Hong YS. Rational biosynthetic engineering for optimization of geldanamycin analogues. Chembiochem : a European Journal of Chemical Biology. 10: 1243-51. PMID 19308924 DOI: 10.1002/Cbic.200800763 |
0.34 |
|
| 2009 |
Nguyen TD, Lee K, Hong YS, Young HK, Chau VM, Jung JL. A peroxisome proliferator-activated receptor-gamma agonist and other constituents from Chromolaena odorata Planta Medica. 75: 803-807. PMID 19242902 DOI: 10.1055/S-0029-1185386 |
0.385 |
|
| 2009 |
Dat NT, Jin X, Lee K, Hong YS, Kim YH, Lee JJ. Hypoxia-inducible factor-1 inhibitory benzofurans and chalcone-derived diels-alder adducts from Morus species. Journal of Natural Products. 72: 39-43. PMID 19072214 DOI: 10.1021/Np800491U |
0.345 |
|
| 2009 |
Jin Y, Rho MC, Gajulapati K, Jung HY, Boovanahalli SK, Lee JH, Song GY, Choi JH, Kim YK, Lee K, Choi Y. Synthesis of a Novel Series of Imidazo(1,2-α)pyridines as Acyl-CoA: Cholesterol Acyltransferase (ACAT) Inhibitors Bulletin of the Korean Chemical Society. 30: 1297-1304. DOI: 10.5012/Bkcs.2009.30.6.1297 |
0.374 |
|
| 2009 |
Shen GN, Choi JH, Gajulapati K, Lee JH, Kim YK, Rho MC, Jung SH, Lee K, Han SS, Song GY, Choi Y. 2-Substitiuted Thio- and Amino-5,8-dimethoxy-1,4-naphthoquinones as a Novel Class of Acyl-CoA: Cholestrol Acyltransferase Inhibitors Bulletin of the Korean Chemical Society. 30: 1088-1092. DOI: 10.5012/Bkcs.2009.30.5.1088 |
0.346 |
|
| 2009 |
Xia Y, Min KH, Lee K. Synthesis and biological evaluation of decursin, prantschimgin and their derivatives Bulletin of the Korean Chemical Society. 30: 43-48. DOI: 10.5012/Bkcs.2009.30.1.043 |
0.318 |
|
| 2008 |
Dat NT, Lee J, Lee K, Hong Y, Kim YH, Lee JJ. Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression. Journal of Natural Products. 71: 1696-1700. PMID 18841906 DOI: 10.1021/Np800383Q |
0.333 |
|
| 2008 |
Lee K, Ryu JS, Jin Y, Kim W, Kaur N, Chung SJ, Jeon YJ, Park JT, Bang JS, Lee HS, Kim TY, Lee JJ, Hong YS. Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites. Organic & Biomolecular Chemistry. 6: 340-8. PMID 18175003 DOI: 10.1039/B713407J |
0.401 |
|
| 2008 |
Song EY, Kaur N, Park MY, Jin Y, Lee K, Kim G, Lee KY, Yang JS, Shin JH, Nam KY, No KT, Han G. Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor. European Journal of Medicinal Chemistry. 43: 1519-24. PMID 18023932 DOI: 10.1016/J.Ejmech.2007.10.008 |
0.383 |
|
| 2007 |
Boovanahalli SK, Jin X, Jin Y, Kim JH, Dat NT, Hong YS, Lee JH, Jung SH, Lee K, Lee JJ. Synthesis of (aryloxyacetylamino)-isonicotinic/nicotinic acid analogues as potent hypoxia-inducible factor (HIF)-1alpha inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 6305-10. PMID 17884495 DOI: 10.1016/J.Bmcl.2007.09.005 |
0.369 |
|
| 2007 |
Kim W, Lee JS, Lee D, Cai XF, Shin JC, Lee K, Lee CH, Ryu S, Paik SG, Lee JJ, Hong YS. Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: generation of structural diversity at the benzoquinone ring. Chembiochem : a European Journal of Chemical Biology. 8: 1491-4. PMID 17661303 DOI: 10.1002/Cbic.200700196 |
0.363 |
|
| 2007 |
Dat NT, Jin X, Lee JH, Lee D, Hong YS, Lee K, Kim YH, Lee JJ. Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1. Journal of Natural Products. 70: 1093-7. PMID 17583950 DOI: 10.1021/Np060482D |
0.345 |
|
| 2007 |
Kang SU, Choi WJ, Oishi S, Lee K, Karki RG, Worthy KM, Bindu LK, Nicklaus MC, Fisher RJ, Burke TR. Examination of acylated 4-aminopiperidine-4-carboxylic acid residues in the phosphotyrosyl+1 position of Grb2 SH2 domain-binding tripeptides. Journal of Medicinal Chemistry. 50: 1978-82. PMID 17371004 DOI: 10.1021/Jm0614073 |
0.314 |
|
| 2007 |
Lee K, Lee JH, Boovanahalli SK, Jin Y, Lee M, Jin X, Kim JH, Hong YS, Lee JJ. (Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors. Journal of Medicinal Chemistry. 50: 1675-84. PMID 17328532 DOI: 10.1021/Jm0610292 |
0.354 |
|
| 2007 |
In JK, Lee MS, Yang JE, Kwak JH, Lee H, Boovanahalli SK, Lee K, Kim SJ, Moon SK, Lee S, Choi NS, Ahn SK, Jung JK. Synthesis of novel diaryl ethers and their evaluation as antimitotic agents. Bioorganic & Medicinal Chemistry Letters. 17: 1799-802. PMID 17276056 DOI: 10.1016/J.Bmcl.2006.12.048 |
0.386 |
|
| 2006 |
Lee J, Koo TH, Yoon H, Jung HS, Jin HZ, Lee K, Hong Y, Lee JJ. Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid Biochemical Pharmacology. 72: 1311-1321. PMID 16984800 DOI: 10.1016/J.Bcp.2006.08.014 |
0.31 |
|
| 2006 |
Cai XF, Jin X, Lee D, Yang YT, Lee K, Hong YS, Lee JH, Lee JJ. Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells. Journal of Natural Products. 69: 1095-7. PMID 16872154 DOI: 10.1021/Np060081Y |
0.332 |
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| 2006 |
Jin HZ, Lee D, Lee JH, Lee K, Hong YS, Choung DH, Kim YH, Lee JJ. New sesquiterpene dimers from Inula britannica inhibit NF-κB activation and NO and TNF-α production in LPS-stimulated RAW264.7 cells Planta Medica. 72: 40-45. PMID 16450294 DOI: 10.1055/S-2005-873189 |
0.314 |
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| 2005 |
Lee D, Lee JH, Cai XF, Shin JC, Lee K, Hong YS, Lee JJ. Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor gamma. The Journal of Antibiotics. 58: 615-20. PMID 16392676 DOI: 10.1038/Ja.2005.84 |
0.352 |
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| 2005 |
Lee K, Boovanahalli SK, Nam KY, Kang SU, Lee M, Phan J, Wu L, Waugh DS, Zhang ZY, No KT, Lee JJ, Burke TR. Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 4037-42. PMID 16039123 DOI: 10.1016/J.Bmcl.2005.06.027 |
0.416 |
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| 2004 |
Shi ZD, Wei CQ, Lee K, Liu H, Zhang M, Araki T, Roberts LR, Worthy KM, Fisher RJ, Neel BG, Kelley JA, Yang D, Burke TR. Macrocyclization in the design of non-phosphorus-containing Grb2 SH2 domain-binding ligands. Journal of Medicinal Chemistry. 47: 2166-9. PMID 15056012 DOI: 10.1021/Jm030510E |
0.336 |
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| 2004 |
Shi ZD, Lee K, Wei CQ, Roberts LR, Worthy KM, Fisher RJ, Burke TR. Synthesis of a 5-methylindolyl-containing macrocycle that displays ultrapotent Grb2 SH2 domain-binding affinity. Journal of Medicinal Chemistry. 47: 788-91. PMID 14761181 DOI: 10.1021/Jm030440B |
0.348 |
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| 2004 |
Liu DG, Gao Y, Voigt JH, Lee K, Nicklaus MC, Wu L, Zhang ZY, Burke TR. Acylsulfonamide-containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration. Bioorganic & Medicinal Chemistry Letters. 13: 3005-7. PMID 12941322 DOI: 10.1016/S0960-894X(03)00635-8 |
0.336 |
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| 2003 |
Phan J, Lee K, Cherry S, Tropea JE, Burke TR, Waugh DS. High-resolution structure of the Yersinia pestis protein tyrosine phosphatase YopH in complex with a phosphotyrosyl mimetic-containing hexapeptide. Biochemistry. 42: 13113-21. PMID 14609321 DOI: 10.1021/Bi030156M |
0.308 |
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| 2003 |
Shi ZD, Lee K, Liu H, Zhang M, Roberts LR, Worthy KM, Fivash MJ, Fisher RJ, Yang D, Burke TR. A novel macrocyclic tetrapeptide mimetic that exhibits low-picomolar Grb2 SH2 domain-binding affinity. Biochemical and Biophysical Research Communications. 310: 378-83. PMID 14521921 DOI: 10.1016/J.Bbrc.2003.09.029 |
0.355 |
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| 2003 |
Lee K, Gao Y, Yao ZJ, Phan J, Wu L, Liang J, Waugh DS, Zhang ZY, Burke TR. Tripeptide inhibitors of Yersinia protein-tyrosine phosphatase. Bioorganic & Medicinal Chemistry Letters. 13: 2577-81. PMID 12852970 DOI: 10.1016/S0960-894X(03)00481-5 |
0.381 |
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| 2003 |
Lee K, Zhang M, Liu H, Yang D, Burke TR. Utilization of a β-Aminophosphotyrosyl Mimetic in the Design and Synthesis of Macrocyclic Grb2 SH2 Domain-Binding Peptides Journal of Medicinal Chemistry. 46: 2621-2630. PMID 12801226 DOI: 10.1021/Jm030049Q |
0.328 |
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| 2003 |
Wei CQ, Gao Y, Lee K, Guo R, Li B, Zhang M, Yang D, Burke TR. Macrocyclization in the Design of Grb2 SH2 Domain-Binding Ligands Exhibiting High Potency in Whole-Cell Systems Journal of Medicinal Chemistry. 46: 244-254. PMID 12519063 DOI: 10.1021/Jm0203635 |
0.347 |
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| 2003 |
Jacobson KA, Kim HS, Ravi G, Kim S, Lee K, Chen A, Chen W, Kim SG, Barak D, Liang BT, Gao Z. Engineering of A3 adenosine and P2Y nucleotide receptors and their ligands Drug Development Research. 58: 330-339. DOI: 10.1002/Ddr.10168 |
0.768 |
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| 2002 |
Gao ZG, Kim SK, Biadatti T, Chen W, Lee K, Barak D, Kim SG, Johnson CR, Jacobson KA. Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary. Journal of Medicinal Chemistry. 45: 4471-84. PMID 12238926 DOI: 10.1021/jm020211 |
0.772 |
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| 2002 |
Ravi RG, Kim HS, Servos J, Zimmermann H, Lee K, Maddileti S, Boyer JL, Harden TK, Jacobson KA. Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists. Journal of Medicinal Chemistry. 45: 2090-100. PMID 11985476 DOI: 10.1021/Jm010538V |
0.642 |
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| 2002 |
Lee K, Choi Y, Gumina G, Zhou W, Schinazi RF, Chu CK. Structure-activity relationships of 2′-fluoro-2′,3′-unsaturated d-nucleosides as anti-hiv-1 agents Journal of Medicinal Chemistry. 45: 1313-1320. PMID 11882000 DOI: 10.1021/Jm010418N |
0.321 |
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| 2002 |
Lee K, Ravi G, Ji XD, Marquez VE, Jacobson KA. Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications. Bioorganic & Medicinal Chemistry Letters. 11: 1333-7. PMID 11392549 DOI: 10.1016/S0960-894X(01)00213-X |
0.532 |
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| 2002 |
Rompaey PV, Jacobson KA, Gao Z, Chen A, Barak D, Kim S, Lee K, Link A, Liang BT, Herdewijn P, Calenbergh SV. Amine-modified nucleosides as adenosine A3 neoceptor ligands Collection of Czechoslovak Chemical Communications. 5: 267-271. DOI: 10.1135/Css200205267 |
0.444 |
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| 2002 |
Lee K, Zhou W, Kelley LC, Momany C, Chu CK. Synthesis of unsaturated fluoride containing d- and l-pyranosyl nucleosides Tetrahedron: Asymmetry. 13: 1589-1598. DOI: 10.1016/S0957-4166(02)00438-X |
0.333 |
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| 2001 |
Jacobson KA, Gao ZG, Chen A, Barak D, Kim SA, Lee K, Link A, Rompaey PV, van Calenbergh S, Liang BT. Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides. Journal of Medicinal Chemistry. 44: 4125-36. PMID 11708915 DOI: 10.1021/Jm010232O |
0.511 |
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| 2001 |
Jacobson KA, Ravi RG, Nandanan E, Kim HS, Moro S, Kim YC, Lee K, Barak D, Marquez VE, Ji XD. Ribose modified nucleosides and nucleotides as ligands for purine receptors. Nucleosides, Nucleotides & Nucleic Acids. 20: 333-41. PMID 11563046 DOI: 10.1081/Ncn-100002305 |
0.74 |
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| 2001 |
Ravi G, Lee K, Ji X, Kim HS, Soltysiak KA, Marquez VE, Jacobson KA. Synthesis and purine receptor affinity of 6-oxopurine nucleosides and nucleotides containing (N)-methanocarba-pseudoribose rings. Bioorganic & Medicinal Chemistry Letters. 11: 2295-300. PMID 11527718 DOI: 10.1016/S0960-894X(01)00450-4 |
0.615 |
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| 2001 |
Lee K, Cass C, Jacobson KA. Synthesis using ring closure metathesis and effect on nucleoside transport of a (N)-methanocarba S-(4-nitrobenzyl)thioinosine derivative. Organic Letters. 3: 597-9. PMID 11178834 DOI: 10.1021/Ol006999C |
0.493 |
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| 1999 |
Lee K, Choi Y, Gullen E, Schlueter-Wirtz S, Schinazi RF, Cheng YC, Chu CK. Synthesis and anti-HIV and anti-HBV activities of 2'-fluoro-2',3'- unsaturated L-nucleosides Journal of Medicinal Chemistry. 42: 1320-1328. PMID 10197975 DOI: 10.1021/Jm980651U |
0.343 |
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