| Year |
Citation |
Score |
| 2022 |
Majerová T, Konvalinka J. Viral proteases as therapeutic targets. Molecular Aspects of Medicine. 88: 101159. PMID 36459838 DOI: 10.1016/j.mam.2022.101159 |
0.356 |
|
| 2021 |
Kryštůfek R, Šácha P, Starková J, Brynda J, Hradilek M, Tloušt'ová E, Grzymska J, Rut W, Boucher MJ, Drąg M, Majer P, Hájek M, Řezáčová P, Madhani HD, Craik CS, ... Konvalinka J, et al. Re-emerging Aspartic Protease Targets: Examining Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery. Journal of Medicinal Chemistry. 64: 6706-6719. PMID 34006103 DOI: 10.1021/acs.jmedchem.0c02177 |
0.372 |
|
| 2019 |
Majerová T, Novotný P, Krýsová E, Konvalinka J. Exploiting the unique features of Zika and Dengue proteases for inhibitor design. Biochimie. 166: 132-141. PMID 31077760 DOI: 10.1016/j.biochi.2019.05.004 |
0.345 |
|
| 2018 |
Humpolíčková J, Weber J, Starková J, Mašínová E, Günterová J, Flaisigová I, Konvalinka J, Majerová T. Inhibition of the precursor and mature forms of HIV-1 protease as a tool for drug evaluation. Scientific Reports. 8: 10438. PMID 29992979 DOI: 10.1038/s41598-018-28638-w |
0.404 |
|
| 2016 |
Hanne J, Göttfert F, Schimer J, Anders-Össwein M, Konvalinka J, Engelhardt J, Müller B, Hell SW, Kräusslich HG. Stimulated Emission Depletion Nanoscopy Reveals Time-Course of Human Immunodeficiency Virus Proteolytic Maturation. Acs Nano. PMID 27517329 DOI: 10.1021/Acsnano.6B03850 |
0.599 |
|
| 2016 |
Kožíšek M, Štěpánek O, Parkan K, Berenguer Albiñana C, Pávová M, Weber J, Krӓusslich HG, Konvalinka J, Machara A. Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly. Bioorganic & Medicinal Chemistry Letters. PMID 27353536 DOI: 10.1016/J.Bmcl.2016.06.039 |
0.344 |
|
| 2016 |
Albiñana CB, Machara A, Řezáčová P, Pachl P, Konvalinka J, Kožíšek M. Kinetic, thermodynamic and structural analysis of tamiphosphor binding to neuraminidase of H1N1 (2009) pandemic influenza. European Journal of Medicinal Chemistry. 121: 100-109. PMID 27236066 DOI: 10.1016/J.Ejmech.2016.05.016 |
0.312 |
|
| 2015 |
Machara A, Lux V, Kozisek M, Grantz-Saskova K, Stepanek O, Kotora M, Parkan K, Pavova M, Glass B, Sehr P, Lewis J, Muller B, Kraeusslich HG, Konvalinka J. Specific inhibitors of HIV capsid assembly binding to the C-terminal domain of the capsid protein: evaluation of 2-arylquinazolines as potential antiviral compounds. Journal of Medicinal Chemistry. PMID 26685880 DOI: 10.1021/Acs.Jmedchem.5B01089 |
0.381 |
|
| 2015 |
Konvalinka J, Kräusslich HG, Müller B. Retroviral proteases and their roles in virion maturation. Virology. 479: 403-17. PMID 25816761 DOI: 10.1016/j.virol.2015.03.021 |
0.645 |
|
| 2015 |
Schimer J, Pávová M, Anders M, Pachl P, Šácha P, Cígler P, Weber J, Majer P, ?ezá?ová P, Kräusslich HG, Müller B, Konvalinka J. Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor. Nature Communications. 6: 6461. PMID 25751579 DOI: 10.1038/ncomms7461 |
0.637 |
|
| 2014 |
Mattei S, Anders M, Konvalinka J, Kräusslich HG, Briggs JA, Müller B. Induced maturation of human immunodeficiency virus. Journal of Virology. 88: 13722-31. PMID 25231305 DOI: 10.1128/JVI.02271-14 |
0.623 |
|
| 2014 |
Kožíšek M, Lepšík M, Grantz Šašková K, Brynda J, Konvalinka J, Rezáčová P. Thermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteases. The Febs Journal. 281: 1834-47. PMID 24785545 DOI: 10.1111/febs.12743 |
0.343 |
|
| 2014 |
Grantz Šašková K, Kozíšek M, Stray K, de Jong D, Rezáová P, Brynda J, van Maarseveen NM, Nijhuis M, Cihlár T, Konvalinka J. GS-8374, a prototype phosphonate-containing inhibitor of HIV-1 protease, effectively inhibits protease mutants with amino acid insertions. Journal of Virology. 88: 3586-90. PMID 24371077 DOI: 10.1128/JVI.02688-13 |
0.447 |
|
| 2014 |
Schimer J, Konvalinka J. Unorthodox inhibitors of HIV protease: looking beyond active-site-directed peptidomimetics. Current Pharmaceutical Design. 20: 3389-97. PMID 24001229 DOI: 10.2174/13816128113199990634 |
0.407 |
|
| 2013 |
Pokorná J, Heyda J, Konvalinka J. Ion specific effects of alkali cations on the catalytic activity of HIV-1 protease. Faraday Discussions. 160: 359-70; discussion 3. PMID 23795510 DOI: 10.1039/C2Fd20094E |
0.396 |
|
| 2013 |
Kozisek M, Durcak J, Konvalinka J. Thermodynamic characterization of the peptide assembly inhibitor binding to HIV-1 capsid protein Retrovirology. 10. DOI: 10.1186/1742-4690-10-S1-P108 |
0.311 |
|
| 2012 |
Schimer J, Cígler P, Veselý J, Grantz Šašková K, Lepšík M, Brynda J, Rezáčová P, Kožíšek M, Císařová I, Oberwinkler H, Kraeusslich HG, Konvalinka J. Structure-aided design of novel inhibitors of HIV protease based on a benzodiazepine scaffold. Journal of Medicinal Chemistry. 55: 10130-5. PMID 23050738 DOI: 10.1021/jm301249q |
0.378 |
|
| 2012 |
KozÃsek M, Henke S, Sasková KG, Jacobs GB, Schuch A, Buchholz B, Müller V, Kräusslich HG, Rezácová P, Konvalinka J, Bodem J. Mutations in HIV-1 gag and pol compensate for the loss of viral fitness caused by a highly mutated protease. Antimicrobial Agents and Chemotherapy. 56: 4320-30. PMID 22644035 DOI: 10.1128/AAC.00465-12 |
0.622 |
|
| 2011 |
Fun A, van Maarseveen NM, Pokorná J, Maas RE, Schipper PJ, Konvalinka J, Nijhuis M. HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat. Retrovirology. 8: 70. PMID 21864346 DOI: 10.1186/1742-4690-8-70 |
0.4 |
|
| 2010 |
Hoffman HE, Jirásková J, Zvelebil M, Konvalinka J. Random mutagenesis of human serine racemase reveals residues important for the enzymatic activity Collection of Czechoslovak Chemical Communications. 75: 59-79. DOI: 10.1135/CCCC2010003 |
0.345 |
|
| 2009 |
Pokorná J, Machala L, Rezáčová P, Konvalinka J. Current and Novel Inhibitors of HIV Protease. Viruses. 1: 1209-39. PMID 21994591 DOI: 10.3390/v1031209 |
0.381 |
|
| 2009 |
Rezácová P, Pokorná J, Brynda J, Kozísek M, Cígler P, Lepsík M, Fanfrlík J, Rezác J, Grantz Sasková K, Sieglová I, Plesek J, Sícha V, Grüner B, Oberwinkler H, Sedlácek' J, ... ... Konvalinka J, et al. Design of HIV protease inhibitors based on inorganic polyhedral metallacarboranes. Journal of Medicinal Chemistry. 52: 7132-41. PMID 19874035 DOI: 10.1021/Jm9011388 |
0.601 |
|
| 2009 |
Hoffman HE, Jirásková J, Cígler P, Sanda M, Schraml J, Konvalinka J. Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor. Journal of Medicinal Chemistry. 52: 6032-41. PMID 19791805 DOI: 10.1021/jm900775q |
0.318 |
|
| 2009 |
Sasková KG, Kozísek M, Rezácová P, Brynda J, Yashina T, Kagan RM, Konvalinka J. Molecular characterization of clinical isolates of human immunodeficiency virus resistant to the protease inhibitor darunavir. Journal of Virology. 83: 8810-8. PMID 19535439 DOI: 10.1128/JVI.00451-09 |
0.422 |
|
| 2008 |
Kozísek M, Cígler P, Lepsík M, Fanfrlík J, Rezácová P, Brynda J, Pokorná J, Plesek J, Grüner B, Grantz Sasková K, Václavíková J, Král V, Konvalinka J. Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance. Journal of Medicinal Chemistry. 51: 4839-43. PMID 18598016 DOI: 10.1021/jm8002334 |
0.404 |
|
| 2008 |
Sasková KG, Kozísek M, Lepsík M, Brynda J, Rezácová P, Václavíková J, Kagan RM, Machala L, Konvalinka J. Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir. Protein Science : a Publication of the Protein Society. 17: 1555-64. PMID 18560011 DOI: 10.1110/ps.036079.108 |
0.303 |
|
| 2008 |
Kozísek M, Sasková KG, Rezácová P, Brynda J, van Maarseveen NM, De Jong D, Boucher CA, Kagan RM, Nijhuis M, Konvalinka J. Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region. Journal of Virology. 82: 5869-78. PMID 18400858 DOI: 10.1128/Jvi.02325-07 |
0.428 |
|
| 2008 |
Bartonová V, Král V, Sieglová I, Brynda J, Fábry M, Horejsí M, Kozísek M, Sasková KG, Konvalinka J, Sedlácek J, Rezácová P. Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies. Antiviral Research. 78: 275-7. PMID 18329737 DOI: 10.1016/j.antiviral.2008.01.009 |
0.357 |
|
| 2007 |
Kozísek M, Bray J, Rezácová P, Sasková K, Brynda J, Pokorná J, Mammano F, Rulísek L, Konvalinka J. Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants. Journal of Molecular Biology. 374: 1005-16. PMID 17977555 DOI: 10.1016/j.jmb.2007.09.083 |
0.402 |
|
| 2007 |
Mlcochová P, Plechanovová A, Barinka C, Mahadevan D, Saldanha JW, Rulísek L, Konvalinka J. Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis. The Febs Journal. 274: 4731-41. PMID 17714508 DOI: 10.1111/J.1742-4658.2007.06021.X |
0.311 |
|
| 2007 |
Nijhuis M, van Maarseveen NM, Lastere S, Schipper P, Coakley E, Glass B, Rovenska M, de Jong D, Chappey C, Goedegebuure IW, Heilek-Snyder G, Dulude D, Cammack N, Brakier-Gingras L, Konvalinka J, et al. A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism. Plos Medicine. 4: e36. PMID 17227139 DOI: 10.1371/Journal.Pmed.0040036 |
0.606 |
|
| 2006 |
Skalova T, Dohnalek J, Duskova J, Petrokova H, Hradílek M, Soucek M, Konvalinka J, Hasek J. HIV-1 protease mutations and inhibitor modifications monitored on a series of complexes. Structural basis for the effect of the A71V mutation on the active site. Journal of Medicinal Chemistry. 49: 5777-84. PMID 16970402 DOI: 10.1021/jm0605583 |
0.386 |
|
| 2006 |
Koval D, Jirásková J, Strísovský K, Konvalinka J, Kasicka V. Capillary electrophoresis method for determination of D-serine and its application for monitoring of serine racemase activity. Electrophoresis. 27: 2558-66. PMID 16721908 DOI: 10.1002/elps.200500946 |
0.653 |
|
| 2006 |
Dusková J, Dohnálek J, Skálová T, Petroková H, Vondrácková E, Hradílek M, Konvalinka J, Soucek M, Brynda J, Fábry M, Sedlácek J, Hasek J. On the role of the R configuration of the reaction-intermediate isostere in HIV-1 protease-inhibitor binding: X-ray structure at 2.0 A resolution. Acta Crystallographica. Section D, Biological Crystallography. 62: 489-97. PMID 16627941 DOI: 10.1107/S0907444906006718 |
0.395 |
|
| 2006 |
Majerová-Uhlíková T, Dantuma NP, Lindsten K, Masucci MG, Konvalinka J. Non-infectious fluorimetric assay for phenotyping of drug-resistant HIV proteinase mutants. Journal of Clinical Virology : the Official Publication of the Pan American Society For Clinical Virology. 36: 50-9. PMID 16527535 DOI: 10.1016/j.jcv.2006.01.014 |
0.338 |
|
| 2005 |
Cígler P, Kozísek M, Rezácová P, Brynda J, Otwinowski Z, Pokorná J, Plesek J, Grüner B, Dolecková-Maresová L, Mása M, Sedlácek J, Bodem J, Kräusslich HG, Král V, Konvalinka J. From nonpeptide toward noncarbon protease inhibitors: metallacarboranes as specific and potent inhibitors of HIV protease. Proceedings of the National Academy of Sciences of the United States of America. 102: 15394-9. PMID 16227435 DOI: 10.1073/pnas.0507577102 |
0.629 |
|
| 2005 |
Strísovský K, Jirásková J, Mikulová A, Rulísek L, Konvalinka J. Dual substrate and reaction specificity in mouse serine racemase: identification of high-affinity dicarboxylate substrate and inhibitors and analysis of the beta-eliminase activity. Biochemistry. 44: 13091-100. PMID 16185077 DOI: 10.1021/bi051201o |
0.654 |
|
| 2004 |
Petroková H, Dusková J, Dohnálek J, Skálová T, Vondrácková-Buchtelová E, Soucek M, Konvalinka J, Brynda J, Fábry M, Sedlácek J, Hasek J. Role of hydroxyl group and R/S configuration of isostere in binding properties of HIV-1 protease inhibitors. European Journal of Biochemistry. 271: 4451-61. PMID 15560786 DOI: 10.1111/j.1432-1033.2004.04384.x |
0.396 |
|
| 2004 |
Svec M, Bauerová H, Pichová I, Konvalinka J, Strísovský K. Proteinases of betaretroviruses bind single-stranded nucleic acids through a novel interaction module, the G-patch. Febs Letters. 576: 271-6. PMID 15474050 DOI: 10.1016/j.febslet.2004.09.010 |
0.645 |
|
| 2004 |
Prejdová J, Soucek M, Konvalinka J. Determining and overcoming resistance to HIV protease inhibitors. Current Drug Targets. Infectious Disorders. 4: 137-52. PMID 15180461 DOI: 10.2174/1568005043340984 |
0.408 |
|
| 2004 |
Brynda J, Rezacova P, Fabry M, Horejsi M, Stouracova R, Sedlacek J, Soucek M, Hradilek M, Lepsik M, Konvalinka J. A phenylnorstatine inhibitor binding to HIV-1 protease: geometry, protonation, and subsite-pocket interactions analyzed at atomic resolution. Journal of Medicinal Chemistry. 47: 2030-6. PMID 15056001 DOI: 10.1021/jm031105q |
0.374 |
|
| 2004 |
Kožíšek M, Prejdová J, Souček M, Machala L, Staňková M, Linka M, Brůčková M, Konvalinka J. Characterisation of Mutated Proteinases Derived from HIV-Positive Patients: Enzyme Activity, Vitality and Inhibition Collection of Czechoslovak Chemical Communications. 69: 703-714. DOI: 10.1135/CCCC20040703 |
0.438 |
|
| 2003 |
Ingr M, Uhlíková T, Strísovský K, Majerová E, Konvalinka J. Kinetics of the dimerization of retroviral proteases: the "fireman's grip" and dimerization. Protein Science : a Publication of the Protein Society. 12: 2173-82. PMID 14500875 DOI: 10.1110/ps.03171903 |
0.69 |
|
| 2003 |
Skálová T, Hasek J, Dohnálek J, Petroková H, Buchtelová E, Dusková J, Soucek M, Majer P, Uhlíková T, Konvalinka J. An ethylenamine inhibitor binds tightly to both wild type and mutant HIV-1 proteases. Structure and energy study. Journal of Medicinal Chemistry. 46: 1636-44. PMID 12699382 DOI: 10.1021/jm021079g |
0.344 |
|
| 2003 |
Strísovský K, Jirásková J, Barinka C, Majer P, Rojas C, Slusher BS, Konvalinka J. Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate. Febs Letters. 535: 44-8. PMID 12560076 DOI: 10.1016/s0014-5793(02)03855-3 |
0.655 |
|
| 2002 |
Weber J, Mesters JR, Lepsík M, Prejdová J, Svec M, Sponarová J, Mlcochová P, Skalická K, Strísovský K, Uhlíková T, Soucek M, Machala L, Stanková M, Vondrásek J, Klimkait T, ... ... Konvalinka J, et al. Unusual binding mode of an HIV-1 protease inhibitor explains its potency against multi-drug-resistant virus strains. Journal of Molecular Biology. 324: 739-54. PMID 12460574 |
0.69 |
|
| 2002 |
Dohnálek J, Hasek J, Dusková J, Petroková H, Hradilek M, Soucek M, Konvalinka J, Brynda J, Sedlácek J, Fábry M. Hydroxyethylamine isostere of an HIV-1 protease inhibitor prefers its amine to the hydroxy group in binding to catalytic aspartates. A synchrotron study of HIV-1 protease in complex with a peptidomimetic inhibitor. Journal of Medicinal Chemistry. 45: 1432-8. PMID 11906284 DOI: 10.1021/jm010979e |
0.376 |
|
| 2002 |
Strísovský K, Smrz D, Fehrmann F, Kräusslich HG, Konvalinka J. The murine endogenous retrovirus MIA14 encodes an active aspartic proteinase that is functionally similar to proteinases from D-type retroviruses. Archives of Biochemistry and Biophysics. 398: 261-8. PMID 11831858 DOI: 10.1006/abbi.2001.2728 |
0.707 |
|
| 2001 |
Lindsten K, Uhlíková T, Konvalinka J, Masucci MG, Dantuma NP. Cell-based fluorescence assay for human immunodeficiency virus type 1 protease activity. Antimicrobial Agents and Chemotherapy. 45: 2616-22. PMID 11502538 DOI: 10.1128/AAC.45.9.2616-2622.2001 |
0.372 |
|
| 2001 |
Dohnálek J, Hasek J, Dusková J, Petroková H, Hradilek M, Soucek M, Konvalinka J, Brynda J, Sedlácek J, Fábry M. A distinct binding mode of a hydroxyethylamine isostere inhibitor of HIV-1 protease. Acta Crystallographica. Section D, Biological Crystallography. 57: 472-6. PMID 11223536 DOI: 10.1107/S0907444900018928 |
0.341 |
|
| 2001 |
Strisovsky K, Tessmer U, Langner J, Konvalinka J, Kräusslich HG. Systematic mutational analysis of the active-site threonine of HIV-1 proteinase: rethinking the "fireman's grip" hypothesis. Protein Science : a Publication of the Protein Society. 9: 1631-41. PMID 11045610 DOI: 10.1110/PS.9.9.1631 |
0.415 |
|
| 2000 |
Rinnová M, Hradilek M, Barinka C, Weber J, Soucek M, Vondrásek J, Klimkait T, Konvalinka J. A picomolar inhibitor of resistant strains of human immunodeficiency virus protease identified by a combinatorial approach. Archives of Biochemistry and Biophysics. 382: 22-30. PMID 11051093 DOI: 10.1006/abbi.2000.2017 |
0.391 |
|
| 1998 |
Konvalinka J, Litera J, Weber J, Vondrásek J, Hradílek M, Soucek M, Pichová I, Majer P, Strop P, Sedlácek J, Heuser AM, Kottler H, Kräusslich HG. Configurations of diastereomeric hydroxyethylene isosteres strongly affect biological activities of a series of specific inhibitors of human-immunodeficiency-virus proteinase. European Journal of Biochemistry. 250: 559-66. PMID 9428710 DOI: 10.1111/J.1432-1033.1997.0559A.X |
0.441 |
|
| 1997 |
Weber J, Majer P, Litera J, Urban J, Soucek M, Vondrásek J, Konvalinka J, Novek P, Sedlácek J, Strop P, Kräusslich HG, Pichová I. Potency comparison of peptidomimetic inhibitors against HIV-1 and HIV-2 proteinases: design of equipotent lead compounds. Archives of Biochemistry and Biophysics. 341: 62-9. PMID 9143353 DOI: 10.1006/abbi.1997.9945 |
0.388 |
|
| 1997 |
Schorr J, Kellner R, Fackler O, Freund J, Konvalinka J, Kienzle N, Kräusslich HG, Mueller-Lantzsch N, Kalbitzer HR. Specific cleavage sites of Nef proteins from human immunodeficiency virus types 1 and 2 for the viral proteases. Journal of Virology. 70: 9051-4. PMID 8971042 DOI: 10.1128/jvi.70.12.9051-9054.1996 |
0.39 |
|
| 1996 |
Uhlíková T, Konvalinka J, Pichová I, Soucek M, Kräusslich HG, Vondrásek J. A modular approach to HIV-1 proteinase inhibitor design. Biochemical and Biophysical Research Communications. 222: 38-43. PMID 8630071 DOI: 10.1006/BBRC.1996.0694 |
0.377 |
|
| 1995 |
Konvalinka J, Löchelt M, Zentgraf H, Flügel RM, Kräusslich HG. Active foamy virus proteinase is essential for virus infectivity but not for formation of a Pol polyprotein. Journal of Virology. 69: 7264-8. PMID 7474150 DOI: 10.1128/jvi.69.11.7264-7268.1995 |
0.304 |
|
| 1995 |
Konvalinka J, Litterst MA, Welker R, Kottler H, Rippmann F, Heuser AM, Kräusslich HG. An active-site mutation in the human immunodeficiency virus type 1 proteinase (PR) causes reduced PR activity and loss of PR-mediated cytotoxicity without apparent effect on virus maturation and infectivity. Journal of Virology. 69: 7180-6. PMID 7474139 DOI: 10.1128/jvi.69.11.7180-7186.1995 |
0.41 |
|
| 1994 |
Freund J, Kellner R, Konvalinka J, Wolber V, Kräusslich HG, Kalbitzer HR. A possible regulation of negative factor (Nef) activity of human immunodeficiency virus type 1 by the viral protease. European Journal of Biochemistry. 223: 589-93. PMID 8055930 DOI: 10.1111/J.1432-1033.1994.TB19029.X |
0.345 |
|
| 1992 |
Strop P, Horejsí M, Konvalinka J, Skrabana R, Velek J, Bláha I, Cerná V, Pichová I, Pavlícková L, Andreánsky M. Protein-engineered proteinase of myeloblastosis associated virus, an enzyme of high activity and HIV-1 proteinase-like specificity. Advances in Experimental Medicine and Biology. 306: 515-8. PMID 1812751 DOI: 10.1007/978-1-4684-6012-4_68 |
0.365 |
|
| 1992 |
Jupp RA, Richards AD, Phylip LH, Kay J, Konvalinka J, Strop P, Kostka V, Scarborough PE, Farmerie WG, Dunn BM. Substrate cleavage by HIV-1 proteinase. Advances in Experimental Medicine and Biology. 306: 461-7. PMID 1812743 DOI: 10.1007/978-1-4684-6012-4_59 |
0.451 |
|
| 1992 |
Griffiths JT, Phylip LH, Konvalinka J, Strop P, Gustchina A, Wlodawer A, Davenport RJ, Briggs R, Dunn BM, Kay J. Different requirements for productive interaction between the active site of HIV-1 proteinase and substrates containing -hydrophobic*hydrophobic- or -aromatic*pro- cleavage sites Biochemistry. 31: 5193-5200. PMID 1606143 DOI: 10.1021/Bi00137A015 |
0.319 |
|
| 1992 |
Urban J, Konvalinka J, Stehlíková J, Gregorová E, Majer P, Soucek M, Andreánsky M, Fábry M, Strop P. Reduced-bond tight-binding inhibitors of HIV-1 protease. Fine tuning of the enzyme subsite specificity. Febs Letters. 298: 9-13. PMID 1544426 DOI: 10.1016/0014-5793(92)80010-E |
0.347 |
|
| 1992 |
Konvalinka J, Horejsí M, Andreánsky M, Novek P, Pichová I, Bláha I, Fábry M, Sedlácek J, Foundling S, Strop P. An engineered retroviral proteinase from myeloblastosis associated virus acquires pH dependence and substrate specificity of the HIV-1 proteinase. The Embo Journal. 11: 1141-1144. DOI: 10.1002/j.1460-2075.1992.tb05154.x |
0.32 |
|
| 1990 |
Konvalinka J, Strop P, Velek J, Cerna V, Kostka V, Phylip LH, Richards AD, Dunn BM, Kay J. Sub-site preferences of the aspartic proteinase from the human immunodeficiency virus, HIV-1 Febs Letters. 268: 35-38. PMID 2200711 DOI: 10.1016/0014-5793(90)80966-M |
0.308 |
|
| 1990 |
Richards AD, Phylip LH, Farmerie WG, Scarborough PE, Alvarez A, Dunn BM, Hirel PH, Konvalinka J, Strop P, Pavlickova L. Sensitive, soluble chromogenic substrates for HIV-1 proteinase. Journal of Biological Chemistry. 265: 7733-7736. DOI: 10.1016/s0021-9258(19)38989-6 |
0.336 |
|
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