| Year |
Citation |
Score |
| 2024 |
Huseby DL, Cao S, Zamaratski E, Sooriyaarachchi S, Ahmad S, Bergfors T, Krasnova L, Pelss J, Ikaunieks M, Loza E, Katkevics M, Bobileva O, Cirule H, Gukalova B, Grinberga S, ... ... Hughes D, et al. Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria. Proceedings of the National Academy of Sciences of the United States of America. 121: e2317274121. PMID 38579010 DOI: 10.1073/pnas.2317274121 |
0.336 |
|
| 2020 |
Brandis G, Granström S, Leber AT, Bartke K, Garoff L, Cao S, Huseby DL, Hughes D. Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response. The Journal of Antimicrobial Chemotherapy. PMID 33221850 DOI: 10.1093/jac/dkaa469 |
0.348 |
|
| 2020 |
Praski Alzrigat L, Huseby DL, Brandis G, Hughes D. Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli. The Journal of Antimicrobial Chemotherapy. PMID 33089314 DOI: 10.1093/jac/dkaa417 |
0.405 |
|
| 2020 |
Nord C, Bjerketorp J, Levenfors JJ, Cao S, Strömstedt AA, Guss B, Larsson R, Hughes D, Öberg B, Broberg A. Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria. Acs Chemical Biology. PMID 33054165 DOI: 10.1021/acschembio.0c00568 |
0.333 |
|
| 2020 |
Garoff L, Pietsch F, Huseby DL, Lilja T, Brandis G, Hughes D. Population bottlenecks strongly influence the evolutionary trajectory to fluoroquinolone resistance in Escherichia coli. Molecular Biology and Evolution. PMID 32031639 DOI: 10.1093/Molbev/Msaa032 |
0.321 |
|
| 2020 |
Huseby DL, Brandis G, Praski Alzrigat L, Hughes D. Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene. Proceedings of the National Academy of Sciences of the United States of America. PMID 31992637 DOI: 10.1073/Pnas.1919390117 |
0.306 |
|
| 2019 |
Juhas M, Widlake E, Teo J, Huseby DL, Tyrrell JM, Polikanov YS, Ercan O, Petersson A, Cao S, Aboklaish AF, Rominski A, Crich D, Böttger EC, Walsh TR, Hughes D, et al. In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii. The Journal of Antimicrobial Chemotherapy. PMID 30629184 DOI: 10.1093/Jac/Dky546 |
0.345 |
|
| 2018 |
Vestö K, Huseby DL, Snygg I, Wang H, Hughes D, Rhen M. Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Serovar Typhimurium. Frontiers in Microbiology. 9: 2941. PMID 30619108 DOI: 10.3389/Fmicb.2018.02941 |
0.436 |
|
| 2018 |
Brandis G, Hughes D. Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB. Scientific Reports. 8: 17488. PMID 30504835 DOI: 10.1038/s41598-018-36005-y |
0.316 |
|
| 2018 |
Pantel L, Florin T, Dobosz-Bartoszek M, Racine E, Sarciaux M, Serri M, Houard J, Campagne JM, de Figueiredo RM, Midrier C, Gaudriault S, Givaudan A, Lanois A, Forst S, Aumelas A, ... ... Hughes D, et al. Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site. Molecular Cell. 70: 83-94.e7. PMID 29625040 DOI: 10.1016/J.Molcel.2018.03.001 |
0.374 |
|
| 2018 |
Jeannot F, Taillier T, Despeyroux P, Renard S, Rey A, Mourez M, Poeverlein C, Khichane I, Perrin MA, Versluys S, Stavenger RA, Huang J, Germe T, Maxwell A, Cao S, ... ... Hughes D, et al. Imidazopyrazinones (IPYs): non-quinolone bacterial topoisomerase inhibitors showing partial cross-resistance with quinolones. Journal of Medicinal Chemistry. PMID 29596745 DOI: 10.1021/Acs.Jmedchem.7B01892 |
0.333 |
|
| 2017 |
Khan DD, Lagerbäck P, Malmberg C, Kristoffersson AN, Gullberg E, Sha C, Cars O, Andersson DI, Hughes D, Nielsen EI, Friberg LE. Predicting mutant selection in competition experiments with ciprofloxacin-exposed escherichia coli. International Journal of Antimicrobial Agents. PMID 29127049 DOI: 10.1016/j.ijantimicag.2017.10.019 |
0.321 |
|
| 2017 |
Garoff L, Yadav K, Hughes D. Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli. The Journal of Antimicrobial Chemotherapy. PMID 29106520 DOI: 10.1093/jac/dkx375 |
0.329 |
|
| 2017 |
Praski Alzrigat L, Huseby DL, Brandis G, Hughes D. Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli. The Journal of Antimicrobial Chemotherapy. PMID 28962020 DOI: 10.1093/Jac/Dkx270 |
0.351 |
|
| 2017 |
Brandis G, Cao S, Huseby DL, Hughes D. Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance. Microbial Cell (Graz, Austria). 4: 275-277. PMID 28845425 DOI: 10.15698/Mic2017.08.587 |
0.447 |
|
| 2017 |
Andersson DI, Hughes D. Selection and Transmission of Antibiotic-Resistant Bacteria. Microbiology Spectrum. 5. PMID 28752817 DOI: 10.1128/microbiolspec.MTBP-0013-2016 |
0.367 |
|
| 2017 |
Hughes D, Andersson DI. Evolutionary Trajectories to Antibiotic Resistance. Annual Review of Microbiology. PMID 28697667 DOI: 10.1146/annurev-micro-090816-093813 |
0.356 |
|
| 2017 |
Cao S, Huseby DL, Brandis G, Hughes D. Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus. Mbio. 8. PMID 28634236 DOI: 10.1128/Mbio.00358-17 |
0.449 |
|
| 2017 |
Banin E, Hughes D, Kuipers OP. Editorial: Bacterial pathogens, antibiotics and antibiotic resistance. Fems Microbiology Reviews. PMID 28486583 DOI: 10.1093/Femsre/Fux016 |
0.367 |
|
| 2017 |
Hughes D, Andersson DI. Environmental and genetic modulation of the phenotypic expression of antibiotic resistance. Fems Microbiology Reviews. PMID 28333270 DOI: 10.1093/femsre/fux004 |
0.344 |
|
| 2017 |
Huseby DL, Pietsch F, Brandis G, Garoff L, Tegehall A, Hughes D. Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli. Molecular Biology and Evolution. PMID 28087782 DOI: 10.1093/Molbev/Msx052 |
0.36 |
|
| 2016 |
Pietsch F, Bergman JM, Brandis G, Marcusson LL, Zorzet A, Huseby DL, Hughes D. Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects. The Journal of Antimicrobial Chemotherapy. PMID 27621175 DOI: 10.1093/Jac/Dkw364 |
0.31 |
|
| 2014 |
Brandis G, Pietsch F, Alemayehu R, Hughes D. Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis. The Journal of Antimicrobial Chemotherapy. 70: 680-5. PMID 25362573 DOI: 10.1093/jac/dku434 |
0.364 |
|
| 2014 |
Marcusson LL, Komp Lindgren P, Olofsson SK, Hughes D, Cars O. Mutant prevention concentrations of pradofloxacin for susceptible and mutant strains of Escherichia coli with reduced fluoroquinolone susceptibility. International Journal of Antimicrobial Agents. 44: 354-7. PMID 25129317 DOI: 10.1016/j.ijantimicag.2014.06.010 |
0.329 |
|
| 2014 |
Hughes D. Selection and evolution of resistance to antimicrobial drugs. Iubmb Life. 66: 521-9. PMID 24933583 DOI: 10.1002/iub.1278 |
0.357 |
|
| 2014 |
Andersson DI, Hughes D. Microbiological effects of sublethal levels of antibiotics. Nature Reviews. Microbiology. 12: 465-78. PMID 24861036 DOI: 10.1038/nrmicro3270 |
0.352 |
|
| 2014 |
Bergman JM, Hammarlöf DL, Hughes D. Reducing ppGpp level rescues an extreme growth defect caused by mutant EF-Tu. Plos One. 9: e90486. PMID 24587376 DOI: 10.1371/journal.pone.0090486 |
0.335 |
|
| 2013 |
Brandis G, Hughes D. Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates. The Journal of Antimicrobial Chemotherapy. 68: 2493-7. PMID 23759506 DOI: 10.1093/jac/dkt224 |
0.323 |
|
| 2012 |
Hughes D, Andersson DI. Selection of resistance at lethal and non-lethal antibiotic concentrations. Current Opinion in Microbiology. 15: 555-60. PMID 22878455 DOI: 10.1016/j.mib.2012.07.005 |
0.384 |
|
| 2012 |
Brandis G, Wrande M, Liljas L, Hughes D. Fitness-compensatory mutations in rifampicin-resistant RNA polymerase. Molecular Microbiology. 85: 142-51. PMID 22646234 DOI: 10.1111/j.1365-2958.2012.08099.x |
0.36 |
|
| 2012 |
Andersson DI, Hughes D. Evolution of antibiotic resistance at non-lethal drug concentrations. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 15: 162-72. PMID 22516308 DOI: 10.1016/j.drup.2012.03.005 |
0.384 |
|
| 2011 |
Lannergård J, Cao S, Norström T, Delgado A, Gustafson JE, Hughes D. Genetic complexity of fusidic acid-resistant small colony variants (SCV) in Staphylococcus aureus. Plos One. 6: e28366. PMID 22140579 DOI: 10.1371/journal.pone.0028366 |
0.336 |
|
| 2011 |
Gullberg E, Cao S, Berg OG, Ilbäck C, Sandegren L, Hughes D, Andersson DI. Selection of resistant bacteria at very low antibiotic concentrations. Plos Pathogens. 7: e1002158. PMID 21811410 DOI: 10.1371/journal.ppat.1002158 |
0.374 |
|
| 2011 |
Andersson DI, Hughes D. Persistence of antibiotic resistance in bacterial populations. Fems Microbiology Reviews. 35: 901-11. PMID 21707669 DOI: 10.1111/j.1574-6976.2011.00289.x |
0.364 |
|
| 2011 |
Nazir H, Cao S, Hasan F, Hughes D. Can phylogenetic type predict resistance development? The Journal of Antimicrobial Chemotherapy. 66: 778-87. PMID 21393154 DOI: 10.1093/jac/dkq505 |
0.302 |
|
| 2010 |
Koskiniemi S, Hughes D, Andersson DI. Effect of translesion DNA polymerases, endonucleases and RpoS on mutation rates in Salmonella typhimurium. Genetics. 185: 783-95. PMID 20421601 DOI: 10.1534/genetics.110.116376 |
0.307 |
|
| 2010 |
Macvanin M, Hughes D.. Assays of sensitivity of antibiotic-resistant bacteria to hydrogen peroxide and measurement of catalase activity Methods Mol Biol.. 642: 95-193. PMID 20401588 DOI: 10.1007/978-1-60327-279-7_7 |
0.567 |
|
| 2010 |
Andersson DI, Hughes D. Antibiotic resistance and its cost: is it possible to reverse resistance? Nature Reviews. Microbiology. 8: 260-71. PMID 20208551 DOI: 10.1038/nrmicro2319 |
0.368 |
|
| 2009 |
Marcusson LL, Frimodt-Møller N, Hughes D. Interplay in the selection of fluoroquinolone resistance and bacterial fitness. Plos Pathogens. 5: e1000541. PMID 19662169 DOI: 10.1371/journal.ppat.1000541 |
0.388 |
|
| 2009 |
Lannergård J, Norström T, Hughes D. Genetic determinants of resistance to fusidic acid among clinical bacteremia isolates of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 53: 2059-65. PMID 19289529 DOI: 10.1128/AAC.00871-08 |
0.413 |
|
| 2008 |
Lannergård J, von Eiff C, Sander G, Cordes T, Seggewiss J, Peters G, Proctor RA, Becker K, Hughes D. Identification of the genetic basis for clinical menadione-auxotrophic small-colony variant isolates of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 52: 4017-22. PMID 18779359 DOI: 10.1128/AAC.00668-08 |
0.329 |
|
| 2008 |
Wrande M, Roth JR, Hughes D. Accumulation of mutants in "aging" bacterial colonies is due to growth under selection, not stress-induced mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 11863-8. PMID 18701713 DOI: 10.1073/Pnas.0804739105 |
0.353 |
|
| 2007 |
Norström T, Lannergård J, Hughes D. Genetic and phenotypic identification of fusidic acid-resistant mutants with the small-colony-variant phenotype in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 51: 4438-46. PMID 17923494 DOI: 10.1128/AAC.00328-07 |
0.43 |
|
| 2007 |
Olofsson SK, Marcusson LL, Strömbäck A, Hughes D, Cars O. Dose-related selection of fluoroquinolone-resistant Escherichia coli. The Journal of Antimicrobial Chemotherapy. 60: 795-801. PMID 17635875 DOI: 10.1093/jac/dkm265 |
0.369 |
|
| 2006 |
Orlén H, Hughes D. Weak mutators can drive the evolution of fluoroquinolone resistance in Escherichia coli. Antimicrobial Agents and Chemotherapy. 50: 3454-6. PMID 17005830 DOI: 10.1128/AAC.00783-06 |
0.321 |
|
| 2006 |
Olofsson SK, Marcusson LL, Komp Lindgren P, Hughes D, Cars O. Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: relation between drug exposure and mutant prevention concentration. The Journal of Antimicrobial Chemotherapy. 57: 1116-21. PMID 16624874 DOI: 10.1093/jac/dkl135 |
0.374 |
|
| 2005 |
Macvanin M, Hughes D.. Hyper-susceptibility of a fusidic acid-resistant mutant of Salmonella to different classes of antibiotics Fems Microbiol Lett. 2005 Jun 15;247(2):215-20. Doi:. 247: 215-220. PMID 15935566 DOI: 10.1016/j.femsle.2005.05.007 |
0.584 |
|
| 2005 |
Komp Lindgren P, Marcusson LL, Sandvang D, Frimodt-Møller N, Hughes D. Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections. Antimicrobial Agents and Chemotherapy. 49: 2343-51. PMID 15917531 DOI: 10.1128/AAC.49.6.2343-2351.2005 |
0.337 |
|
| 2004 |
Macvanin M, Ballagi A, Hughes D.. Fusidic acid-resistant mutants of Salmonella enterica serovar typhimurium have low levels of heme and a reduced rate of respiration and are sensitive to oxidative stress Antimicrob Agents Chemother.. 48: 3877-3883. PMID 15388448 DOI: 10.1128/AAC.48.10.3877-3883.2004 |
0.593 |
|
| 2004 |
Komp Lindgren P, Karlsson A, Hughes D. Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. Antimicrobial Agents and Chemotherapy. 47: 3222-32. PMID 14506034 DOI: 10.1128/AAC.47.10.3222-3232.2003 |
0.328 |
|
| 2003 |
Macvanin M, Björkman J, Eriksson S, Rhen M, Andersson DI, Hughes D. Fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium with low fitness in vivo are defective in RpoS induction. Antimicrobial Agents and Chemotherapy. 47: 3743-9. PMID 14638476 |
0.415 |
|
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