| Year |
Citation |
Score |
| 2024 |
Gabrielle M, Yudin Y, Wang Y, Su X, Rohacs T. Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity. Nature Communications. 15: 7020. PMID 39147733 DOI: 10.1038/s41467-024-51181-4 |
0.383 |
|
| 2024 |
Gabrielle M, Yudin Y, Wang Y, Su X, Rohacs T. Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity. Biorxiv : the Preprint Server For Biology. PMID 38464030 DOI: 10.1101/2024.03.01.582964 |
0.382 |
|
| 2024 |
Pumroy RA, De Jesús-Pérez JJ, Protopopova AD, Rocereta JA, Fluck EC, Fricke T, Lee BH, Rohacs T, Leffler A, Moiseenkova-Bell V. Molecular details of ruthenium red pore block in TRPV channels. Embo Reports. PMID 38225355 DOI: 10.1038/s44319-023-00050-0 |
0.492 |
|
| 2023 |
De Jesús-Pérez JJ, Gabrielle M, Raheem S, Fluck EC, Rohacs T, Moiseenkova-Bell VY. Structural mechanism of TRPV5 inhibition by econazole. Structure (London, England : 1993). PMID 38141613 DOI: 10.1016/j.str.2023.11.012 |
0.421 |
|
| 2023 |
Rohacs T. Phosphoinositide Regulation of TRP Channels: A Functional Overview in the Structural Era. Annual Review of Physiology. PMID 37871124 DOI: 10.1146/annurev-physiol-042022-013956 |
0.608 |
|
| 2023 |
Lee BH, De Jesús Pérez JJ, Moiseenkova-Bell V, Rohacs T. Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A. Nature Communications. 14: 5883. PMID 37735536 DOI: 10.1038/s41467-023-41577-z |
0.58 |
|
| 2023 |
Gabrielle M, Rohacs T. TMEM120A/TACAN: A putative regulator of ion channels, mechanosensation, and lipid metabolism. Channels (Austin, Tex.). 17: 2237306. PMID 37523628 DOI: 10.1080/19336950.2023.2237306 |
0.471 |
|
| 2023 |
Burglen L, Van Hoeymissen E, Qebibo L, Barth M, Belnap N, Boschann F, Depienne C, De Clercq K, Douglas AGL, Fitzgerald MP, Foulds N, Garel C, Helbig I, Held K, Horn D, ... ... Rohacs T, et al. Gain-of-function variants in the ion channel gene underlie a spectrum of neurodevelopmental disorders. Elife. 12. PMID 36648066 DOI: 10.7554/eLife.81032 |
0.395 |
|
| 2022 |
Zhao S, Carnevale V, Gabrielle M, Gianti E, Rohacs T. Computational and functional studies of the PI(4,5)P binding site of the TRPM3 ion channel reveal interactions with other regulators. The Journal of Biological Chemistry. 102547. PMID 36181791 DOI: 10.1016/j.jbc.2022.102547 |
0.458 |
|
| 2022 |
Rohacs T, Fluck EC, De Jesús-Pérez JJ, Moiseenkova-Bell VY. What structures did, and did not, reveal about the function of the epithelial Ca channels TRPV5 and TRPV6. Cell Calcium. 106: 102620. PMID 35834842 DOI: 10.1016/j.ceca.2022.102620 |
0.591 |
|
| 2022 |
Del Rosario JS, Gabrielle M, Yudin Y, Rohacs T. TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels. The Journal of General Physiology. 154. PMID 35819364 DOI: 10.1085/jgp.202213164 |
0.795 |
|
| 2022 |
Fluck EC, Yazici AT, Rohacs T, Moiseenkova-Bell VY. Structural basis of TRPV5 regulation by physiological and pathophysiological modulators. Cell Reports. 39: 110737. PMID 35476976 DOI: 10.1016/j.celrep.2022.110737 |
0.597 |
|
| 2021 |
Yudin Y, Liu L, Nagwekar J, Rohacs T. Methods to study phosphoinositide regulation of ion channels. Methods in Enzymology. 652: 49-79. PMID 34059290 DOI: 10.1016/bs.mie.2021.01.025 |
0.465 |
|
| 2021 |
Zhao S, Rohacs T. The newest TRP channelopathy: Gain of function TRPM3 mutations cause epilepsy and intellectual disability. Channels (Austin, Tex.). 15: 386-397. PMID 33853504 DOI: 10.1080/19336950.2021.1908781 |
0.413 |
|
| 2021 |
Yazici AT, Gianti E, Kasimova MA, Lee BH, Carnevale V, Rohacs T. Dual regulation of TRPV1 channels by phosphatidylinositol via functionally distinct binding sites. The Journal of Biological Chemistry. 296: 100573. PMID 33766560 DOI: 10.1016/j.jbc.2021.100573 |
0.481 |
|
| 2021 |
Jiang W, Del Rosario JS, Botello-Smith W, Zhao S, Lin YC, Zhang H, Lacroix J, Rohacs T, Luo YL. Crowding-induced opening of the mechanosensitive Piezo1 channel in silico. Communications Biology. 4: 84. PMID 33469156 DOI: 10.1038/s42003-020-01600-1 |
0.777 |
|
| 2020 |
Kelemen B, Pinto S, Kim N, Lisztes E, Hanyicska M, Vladár A, Oláh A, Pénzes Z, Shu B, Vriens J, Bíró T, Rohács T, Voets T, Tóth BI. The TRPM3 ion channel mediates pain nociception but not itch evoked by endogenous pruritogenic mediators. Biochemical Pharmacology. 114310. PMID 33130130 DOI: 10.1016/j.bcp.2020.114310 |
0.469 |
|
| 2020 |
Behrendt M, Gruss F, Enzeroth R, Dembla S, Zhao S, Crassous PA, Mohr F, Nys M, Louros N, Gallardo R, Zorzini V, Wagner D, Economou A, Rousseau F, Schymkowitz J, ... ... Rohacs T, et al. The structural basis for an on-off switch controlling Gβγ-mediated inhibition of TRPM3 channels. Proceedings of the National Academy of Sciences of the United States of America. PMID 33122432 DOI: 10.1073/pnas.2001177117 |
0.471 |
|
| 2020 |
Liu L, Yudin Y, Rohacs T. Diacylglycerol kinases regulate TRPV1 channel activity. The Journal of Biological Chemistry. 295: 8174-8185. PMID 32345612 DOI: 10.1074/jbc.RA119.012505 |
0.619 |
|
| 2020 |
Zhao S, Yudin Y, Rohacs T. Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms. Elife. 9. PMID 32343227 DOI: 10.7554/eLife.55634 |
0.377 |
|
| 2020 |
Del Rosario JS, Yudin Y, Su S, Hartle CM, Mirshahi T, Rohacs T. Gi-coupled receptor activation potentiates Piezo2 currents via Gβγ. Embo Reports. e49124. PMID 32227462 DOI: 10.15252/embr.201949124 |
0.774 |
|
| 2020 |
Liu L, Rohacs T. Regulation of the cold-sensing TRPM8 channels by phosphoinositides and G-coupled receptors. Channels (Austin, Tex.). 14: 79-86. PMID 32101066 DOI: 10.1080/19336950.2020.1734266 |
0.594 |
|
| 2019 |
Hughes TE, Del Rosario JS, Kapoor A, Yazici AT, Yudin Y, Fluck EC, Filizola M, Rohacs T, Moiseenkova-Bell VY. Structure-based characterization of novel TRPV5 inhibitors. Elife. 8. PMID 31647410 DOI: 10.7554/Elife.49572 |
0.77 |
|
| 2019 |
Pumroy RA, Samanta A, Liu Y, Hughes TE, Zhao S, Yudin Y, Rohacs T, Han S, Moiseenkova-Bell VY. Molecular mechanism of TRPV2 channel modulation by cannabidiol. Elife. 8. PMID 31566564 DOI: 10.7554/eLife.48792 |
0.528 |
|
| 2019 |
Liu L, Yudin Y, Nagwekar J, Kang C, Shirokova N, Rohacs T. G sensitizes TRPM8 to inhibition by PI(4,5)P depletion upon receptor activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31127000 DOI: 10.1523/Jneurosci.2304-18.2019 |
0.568 |
|
| 2019 |
Yudin Y, Rohacs T. The G-protein-biased agents PZM21 and TRV130 are partial agonists of μ-opioid receptor-mediated signalling to ion channels. British Journal of Pharmacology. 176: 3110-3125. PMID 31074038 DOI: 10.1111/bph.14702 |
0.316 |
|
| 2019 |
Robinson CV, Rohacs T, Hansen SB. Tools for Understanding Nanoscale Lipid Regulation of Ion Channels. Trends in Biochemical Sciences. PMID 31060927 DOI: 10.1016/J.Tibs.2019.04.001 |
0.427 |
|
| 2018 |
Kasimova MA, Yazici AT, Yudin Y, Granata D, Klein ML, Rohacs T, Carnevale V. A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine. The Journal of General Physiology. PMID 30333107 DOI: 10.1085/Jgp.201812124 |
0.41 |
|
| 2018 |
Hughes TET, Pumroy RA, Yazici AT, Kasimova MA, Fluck EC, Huynh KW, Samanta A, Molugu SK, Zhou ZH, Carnevale V, Rohacs T, Moiseenkova-Bell VY. Structural insights on TRPV5 gating by endogenous modulators. Nature Communications. 9: 4198. PMID 30305626 DOI: 10.1038/s41467-018-06753-6 |
0.526 |
|
| 2018 |
Yudin Y, Rohacs T. Inhibitory G-coupled receptors in somatosensory neurons: Potential therapeutic targets for novel analgesics. Molecular Pain. 14: 1744806918763646. PMID 29580154 DOI: 10.1177/1744806918763646 |
0.388 |
|
| 2018 |
Kasimova MA, Yazici A, Yudin Y, Granata D, Klein ML, Rohacs T, Carnevale V. Ion Channel Sensing: Are Fluctuations the Crux of the Matter? The Journal of Physical Chemistry Letters. PMID 29439562 DOI: 10.1021/Acs.Jpclett.7B03396 |
0.308 |
|
| 2018 |
Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY. Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM. Nature Structural & Molecular Biology. 25: 53-60. PMID 29323279 DOI: 10.1038/S41594-017-0009-1 |
0.8 |
|
| 2017 |
Badheka D, Yudin Y, Borbiro I, Hartle CM, Yazici A, Mirshahi T, Rohacs T. Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits. Elife. 6. PMID 28829742 DOI: 10.7554/eLife.26147 |
0.53 |
|
| 2016 |
Carnevale V, Rohacs T. TRPV1: A Target for Rational Drug Design. Pharmaceuticals (Basel, Switzerland). 9. PMID 27563913 DOI: 10.3390/ph9030052 |
0.466 |
|
| 2016 |
Velisetty P, Borbiro I, Kasimova MA, Liu L, Badheka D, Carnevale V, Rohacs T. A molecular determinant of phosphoinositide affinity in mammalian TRPV channels. Scientific Reports. 6: 27652. PMID 27291418 DOI: 10.1038/srep27652 |
0.561 |
|
| 2016 |
Badheka D, Rohacs T. TRPM3 joins the ranks of PI(4,5)P2 sensitive ion channels. Channels (Austin, Tex.). 9: 233-4. PMID 26542627 DOI: 10.1080/19336950.2015.1089072 |
0.481 |
|
| 2016 |
Badheka D, Borbiro I, Rohacs T. Transient receptor potential melastatin 3 is a phosphoinositide-dependent ion channel. The Journal of General Physiology. 146: 65-77. PMID 26123195 DOI: 10.1085/jgp.201411336 |
0.641 |
|
| 2015 |
Rohacs T. Phosphoinositide signaling in somatosensory neurons. Advances in Biological Regulation. 61: 2-16. PMID 26724974 DOI: 10.1016/j.jbior.2015.11.012 |
0.311 |
|
| 2015 |
Elokely K, Velisetty P, Delemotte L, Palovcak E, Klein ML, Rohacs T, Carnevale V. Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin. Proceedings of the National Academy of Sciences of the United States of America. PMID 26719417 DOI: 10.1073/Pnas.1517288113 |
0.37 |
|
| 2015 |
Rohacs T. Phosphoinositide regulation of TRPV1 revisited. Pflugers Archiv : European Journal of Physiology. 467: 1851-69. PMID 25754030 DOI: 10.1007/s00424-015-1695-3 |
0.655 |
|
| 2015 |
Borbiro I, Badheka D, Rohacs T. Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides. Science Signaling. 8: ra15. PMID 25670203 DOI: 10.1126/scisignal.2005667 |
0.673 |
|
| 2015 |
Gamper N, Rohacs T. Phosphoinositide sensitivity of ion channels, a functional perspective. Sub-Cellular Biochemistry. 59: 289-333. PMID 22374095 DOI: 10.1007/978-94-007-3015-1_10 |
0.569 |
|
| 2014 |
Rohacs T. Phosphoinositide regulation of TRP channels. Handbook of Experimental Pharmacology. 223: 1143-76. PMID 24961984 DOI: 10.1007/978-3-319-05161-1_18 |
0.609 |
|
| 2013 |
Lukacs V, Rives JM, Sun X, Zakharian E, Rohacs T. Promiscuous activation of transient receptor potential vanilloid 1 (TRPV1) channels by negatively charged intracellular lipids: the key role of endogenous phosphoinositides in maintaining channel activity. The Journal of Biological Chemistry. 288: 35003-13. PMID 24158445 DOI: 10.1074/jbc.M113.520288 |
0.801 |
|
| 2013 |
Rohacs T. Regulation of transient receptor potential channels by the phospholipase C pathway. Advances in Biological Regulation. 53: 341-55. PMID 23916247 DOI: 10.1016/j.jbior.2013.07.004 |
0.584 |
|
| 2013 |
Cao C, Yudin Y, Bikard Y, Chen W, Liu T, Li H, Jendrossek D, Cohen A, Pavlov E, Rohacs T, Zakharian E. Polyester modification of the mammalian TRPM8 channel protein: implications for structure and function. Cell Reports. 4: 302-315. PMID 23850286 DOI: 10.1016/j.celrep.2013.06.022 |
0.496 |
|
| 2013 |
Lukacs V, Yudin Y, Hammond GR, Sharma E, Fukami K, Rohacs T. Distinctive changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11451-63. PMID 23843517 DOI: 10.1523/JNEUROSCI.5637-12.2013 |
0.8 |
|
| 2013 |
Rohacs T. Recording macroscopic currents in large patches from Xenopus oocytes. Methods in Molecular Biology (Clifton, N.J.). 998: 119-31. PMID 23529425 DOI: 10.1007/978-1-62703-351-0_9 |
0.476 |
|
| 2013 |
Cao C, Zakharian E, Borbiro I, Rohacs T. Interplay between calmodulin and phosphatidylinositol 4,5-bisphosphate in Ca2+-induced inactivation of transient receptor potential vanilloid 6 channels. The Journal of Biological Chemistry. 288: 5278-90. PMID 23300090 DOI: 10.1074/jbc.M112.409482 |
0.488 |
|
| 2013 |
Rohacs T. Sphingosine and the transient receptor potential channel kinase(s). British Journal of Pharmacology. 168: 1291-3. PMID 23186176 DOI: 10.1111/bph.12070 |
0.546 |
|
| 2012 |
Rohacs T. Cool channel subunits reveal their independent interactions with menthol. The Journal of Physiology. 589: 4809. PMID 22001726 DOI: 10.1113/jphysiol.2011.219543 |
0.43 |
|
| 2011 |
Yudin Y, Rohacs T. Regulation of TRPM8 channel activity. Molecular and Cellular Endocrinology. 353: 68-74. PMID 22061619 DOI: 10.1016/j.mce.2011.10.023 |
0.508 |
|
| 2011 |
Yudin Y, Lukacs V, Cao C, Rohacs T. Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels. The Journal of Physiology. 589: 6007-27. PMID 22005680 DOI: 10.1113/jphysiol.2011.220228 |
0.801 |
|
| 2011 |
Zakharian E, Cao C, Rohacs T. Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) P₂. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3915-28. PMID 21810903 DOI: 10.1096/fj.11-184630 |
0.627 |
|
| 2010 |
Zakharian E, Cao C, Rohacs T. Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 12526-34. PMID 20844147 DOI: 10.1523/JNEUROSCI.3189-10.2010 |
0.623 |
|
| 2009 |
Zakharian E, Thyagarajan B, French RJ, Pavlov E, Rohacs T. Inorganic polyphosphate modulates TRPM8 channels Plos One. 4. PMID 19404398 DOI: 10.1371/journal.pone.0005404 |
0.579 |
|
| 2009 |
Rohacs T. Phosphoinositide regulation of non-canonical transient receptor potential channels. Cell Calcium. 45: 554-65. PMID 19376575 DOI: 10.1016/j.ceca.2009.03.011 |
0.594 |
|
| 2009 |
Thyagarajan B, Benin BS, Christakos S, Rohacs T. Phospholipase C-mediated regulation of transient receptor potential vanilloid 6 channels: implications in active intestinal Ca 2+ transport Molecular Pharmacology. 75: 608-616. PMID 19073818 DOI: 10.1124/mol.108.052449 |
0.435 |
|
| 2008 |
Rohacs T, Thyagarajan B, Lukacs V. Phospholipase C mediated modulation of TRPV1 channels Molecular Neurobiology. 37: 153-163. PMID 18528787 DOI: 10.1007/s12035-008-8027-y |
0.809 |
|
| 2008 |
Thyagarajan B, Lukacs V, Rohacs T. Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels Journal of Biological Chemistry. 283: 14980-14987. PMID 18390907 DOI: 10.1074/jbc.M704224200 |
0.788 |
|
| 2007 |
Lopes CM, Remon JI, Matavel A, Sui JL, Keselman I, Medei E, Shen Y, Rosenhouse-Dantsker A, Rohacs T, Logothetis DE. Protein kinase A modulates PLC-dependent regulation and PIP2-sensitivity of K+ channels. Channels (Austin, Tex.). 1: 124-34. PMID 18690021 DOI: 10.4161/Chan.4322 |
0.537 |
|
| 2007 |
Lukacs V, Thyagarajan B, Varnai P, Balla A, Balla T, Rohacs T. Dual regulation of TRPV1 by phosphoinositides Journal of Neuroscience. 27: 7070-7080. PMID 17596456 DOI: 10.1523/JNEUROSCI.1866-07.2007 |
0.787 |
|
| 2007 |
Rohacs T, Nilius B. Regulation of transient receptor potential (TRP) channels by phosphoinositides. Pflugers Archiv : European Journal of Physiology. 455: 157-68. PMID 17479281 DOI: 10.1007/s00424-007-0275-6 |
0.56 |
|
| 2006 |
Varnai P, Thyagarajan B, Rohacs T, Balla T. Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells Journal of Cell Biology. 175: 377-382. PMID 17088424 DOI: /10.1083/jcb.200607116 |
0.406 |
|
| 2006 |
Rohacs T. Regulation of TRP channels by PIP(2). Pflugers Archiv : European Journal of Physiology. 453: 753-62. PMID 17031667 DOI: 10.1007/s00424-006-0153-7 |
0.534 |
|
| 2005 |
Rohacs T. Teaching resources. TRP channels. Science's Stke : Signal Transduction Knowledge Environment. 2005: tr14. PMID 15870425 DOI: 10.1126/stke.2822005tr14 |
0.407 |
|
| 2005 |
Rohács T, Lopes CM, Michailidis I, Logothetis DE. PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nature Neuroscience. 8: 626-34. PMID 15852009 DOI: 10.1038/Nn1451 |
0.618 |
|
| 2005 |
Lopes CM, Rohács T, Czirják G, Balla T, Enyedi P, Logothetis DE. PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels. The Journal of Physiology. 564: 117-29. PMID 15677683 DOI: 10.1113/Jphysiol.2004.081935 |
0.588 |
|
| 2004 |
Du X, Zhang H, Lopes C, Mirshahi T, Rohacs T, Logothetis DE. Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators. The Journal of Biological Chemistry. 279: 37271-81. PMID 15155739 DOI: 10.1074/Jbc.M403413200 |
0.537 |
|
| 2003 |
Zhang H, Craciun LC, Mirshahi T, Rohács T, Lopes CM, Jin T, Logothetis DE. PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents. Neuron. 37: 963-75. PMID 12670425 DOI: 10.1016/S0896-6273(03)00125-9 |
0.575 |
|
| 2003 |
Rohács T, Lopes CM, Jin T, Ramdya PP, Molnár Z, Logothetis DE. Specificity of activation by phosphoinositides determines lipid regulation of Kir channels. Proceedings of the National Academy of Sciences of the United States of America. 100: 745-50. PMID 12525701 DOI: 10.1073/Pnas.0236364100 |
0.547 |
|
| 2002 |
Jin T, Peng L, Mirshahi T, Rohacs T, Chan KW, Sanchez R, Logothetis DE. The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment. Molecular Cell. 10: 469-81. PMID 12408817 DOI: 10.1016/S1097-2765(02)00659-7 |
0.407 |
|
| 2002 |
Lopes CM, Zhang H, Rohacs T, Jin T, Yang J, Logothetis DE. Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies. Neuron. 34: 933-44. PMID 12086641 DOI: 10.1016/S0896-6273(02)00725-0 |
0.491 |
|
| 2002 |
Rohács T, Lopes C, Mirshahi T, Jin T, Zhang H, Logothetis DE. Assaying phosphatidylinositol bisphosphate regulation of potassium channels. Methods in Enzymology. 345: 71-92. PMID 11665643 DOI: 10.1016/S0076-6879(02)45008-2 |
0.505 |
|
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