| Year |
Citation |
Score |
| 2018 |
Gómez Santiago C, Paci E, Donnelly D. A mechanism for agonist activation of the glucagon-like peptide-1 (GLP-1) receptor through modelling & molecular dynamics. Biochemical and Biophysical Research Communications. 498: 359-365. PMID 29397068 DOI: 10.1016/j.bbrc.2018.01.110 |
0.539 |
|
| 2016 |
Weaver RE, Carlos Mobarec J, Wigglesworth MJ, Reynolds CA, Donnelly D. High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5. Biochemical Pharmacology. PMID 28012961 DOI: 10.1016/J.Bcp.2016.12.013 |
0.767 |
|
| 2016 |
Graaf C, Donnelly D, Wootten D, Lau J, Sexton PM, Miller LJ, Ahn JM, Liao J, Fletcher MM, Yang D, Brown AJ, Zhou C, Deng J, Wang MW. Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes. Pharmacological Reviews. 68: 954-1013. PMID 27630114 DOI: 10.1124/pr.115.011395 |
0.566 |
|
| 2015 |
Dods RL, Donnelly D. The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling. Bioscience Reports. 36: e00285. PMID 26598711 DOI: 10.1042/BSR20150253 |
0.842 |
|
| 2014 |
Weaver RE, Wigglesworth MJ, Donnelly D. A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity. Peptides. 61: 83-7. PMID 25218037 DOI: 10.1016/j.peptides.2014.09.004 |
0.733 |
|
| 2014 |
Al-Sabah S, Al-Fulaij M, Shaaban G, Ahmed HA, Mann RJ, Donnelly D, Bünemann M, Krasel C. The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively. Plos One. 9: e106890. PMID 25191754 DOI: 10.1371/Journal.Pone.0106890 |
0.763 |
|
| 2014 |
Kumar A, Gopalswamy M, Wishart C, Henze M, Eschen-Lippold L, Donnelly D, Balbach J. N-terminal phosphorylation of parathyroid hormone (PTH) abolishes its receptor activity. Acs Chemical Biology. 9: 2465-70. PMID 25158085 DOI: 10.1021/Cb5004515 |
0.724 |
|
| 2012 |
Donnelly D. The structure and function of the glucagon-like peptide-1 receptor and its ligands. British Journal of Pharmacology. 166: 27-41. PMID 21950636 DOI: 10.1111/j.1476-5381.2011.01687.x |
0.432 |
|
| 2010 |
Mann RJ, Al-Sabah S, de Maturana RL, Sinfield JK, Donnelly D. Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket. Peptides. 31: 2289-93. PMID 20869417 DOI: 10.1016/j.peptides.2010.09.015 |
0.699 |
|
| 2010 |
Chapman KL, Kinsella GK, Cox A, Donnelly D, Findlay JB. Interactions of the melanocortin-4 receptor with the peptide agonist NDP-MSH. Journal of Molecular Biology. 401: 433-50. PMID 20600126 DOI: 10.1016/j.jmb.2010.06.028 |
0.783 |
|
| 2010 |
Miller PS, Barwell J, Poyner DR, Wigglesworth MJ, Garland SL, Donnelly D. Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74. Biochemical and Biophysical Research Communications. 391: 437-42. PMID 19914210 DOI: 10.1016/j.bbrc.2009.11.076 |
0.757 |
|
| 2010 |
Barwell J, Miller PS, Donnelly D, Poyner DR. Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptor. Peptides. 31: 170-6. PMID 19913063 DOI: 10.1016/j.peptides.2009.10.021 |
0.775 |
|
| 2008 |
Mann R, Wigglesworth MJ, Donnelly D. Ligand-receptor interactions at the parathyroid hormone receptors: subtype binding selectivity is mediated via an interaction between residue 23 on the ligand and residue 41 on the receptor. Molecular Pharmacology. 74: 605-13. PMID 18539702 DOI: 10.1124/mol.108.048017 |
0.818 |
|
| 2005 |
Ellis J, Warburton P, Donnelly D, Balmforth AJ. Conformational induction is the key process for activation of the AT1 receptor. Biochemical Pharmacology. 71: 464-71. PMID 16343447 DOI: 10.1016/j.bcp.2005.11.011 |
0.65 |
|
| 2005 |
Cox A, Donnelly D, Kaur M, Cheetham SC, Cockcroft VB, Findlay JB. MTSEA prevents ligand binding to the human melanocortin-4 receptor by modification of cysteine 130 in transmembrane helix 3. Febs Letters. 579: 285-91. PMID 15620728 DOI: 10.1016/j.febslet.2004.11.087 |
0.683 |
|
| 2004 |
López de Maturana R, Treece-Birch J, Abidi F, Findlay JB, Donnelly D. Met-204 and Tyr-205 are together important for binding GLP-1 receptor agonists but not their N-terminally truncated analogues. Protein and Peptide Letters. 11: 15-22. PMID 14965274 |
0.74 |
|
| 2004 |
Al-Sabah S, Donnelly D. The primary ligand-binding interaction at the GLP-1 receptor is via the putative helix of the peptide agonists. Protein and Peptide Letters. 11: 9-14. PMID 14965273 DOI: 10.2174/0929866043478365 |
0.85 |
|
| 2003 |
Al-Sabah S, Donnelly D. The positive charge at Lys-288 of the glucagon-like peptide-1 (GLP-1) receptor is important for binding the N-terminus of peptide agonists. Febs Letters. 553: 342-6. PMID 14572647 DOI: 10.1016/s0014-5793(03)01043-3 |
0.85 |
|
| 2003 |
Al-Sabah S, Donnelly D. A model for receptor-peptide binding at the glucagon-like peptide-1 (GLP-1) receptor through the analysis of truncated ligands and receptors. British Journal of Pharmacology. 140: 339-46. PMID 12970080 DOI: 10.1038/sj.bjp.0705453 |
0.857 |
|
| 2003 |
López de Maturana R, Willshaw A, Kuntzsch A, Rudolph R, Donnelly D. The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1. The Journal of Biological Chemistry. 278: 10195-200. PMID 12524435 DOI: 10.1074/jbc.M212147200 |
0.613 |
|
| 2002 |
López de Maturana R, Donnelly D. The glucagon-like peptide-1 receptor binding site for the N-terminus of GLP-1 requires polarity at Asp198 rather than negative charge. Febs Letters. 530: 244-8. PMID 12387900 DOI: 10.1016/s0014-5793(02)03492-0 |
0.549 |
|
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