Year |
Citation |
Score |
2018 |
Gómez Santiago C, Paci E, Donnelly D. A mechanism for agonist activation of the glucagon-like peptide-1 (GLP-1) receptor through modelling & molecular dynamics. Biochemical and Biophysical Research Communications. 498: 359-365. PMID 29397068 DOI: 10.1016/j.bbrc.2018.01.110 |
0.539 |
|
2016 |
Weaver RE, Carlos Mobarec J, Wigglesworth MJ, Reynolds CA, Donnelly D. High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5. Biochemical Pharmacology. PMID 28012961 DOI: 10.1016/J.Bcp.2016.12.013 |
0.767 |
|
2016 |
Graaf C, Donnelly D, Wootten D, Lau J, Sexton PM, Miller LJ, Ahn JM, Liao J, Fletcher MM, Yang D, Brown AJ, Zhou C, Deng J, Wang MW. Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes. Pharmacological Reviews. 68: 954-1013. PMID 27630114 DOI: 10.1124/pr.115.011395 |
0.566 |
|
2015 |
Dods RL, Donnelly D. The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling. Bioscience Reports. 36: e00285. PMID 26598711 DOI: 10.1042/BSR20150253 |
0.842 |
|
2014 |
Weaver RE, Wigglesworth MJ, Donnelly D. A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity. Peptides. 61: 83-7. PMID 25218037 DOI: 10.1016/j.peptides.2014.09.004 |
0.733 |
|
2014 |
Al-Sabah S, Al-Fulaij M, Shaaban G, Ahmed HA, Mann RJ, Donnelly D, Bünemann M, Krasel C. The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively. Plos One. 9: e106890. PMID 25191754 DOI: 10.1371/Journal.Pone.0106890 |
0.763 |
|
2014 |
Kumar A, Gopalswamy M, Wishart C, Henze M, Eschen-Lippold L, Donnelly D, Balbach J. N-terminal phosphorylation of parathyroid hormone (PTH) abolishes its receptor activity. Acs Chemical Biology. 9: 2465-70. PMID 25158085 DOI: 10.1021/Cb5004515 |
0.724 |
|
2012 |
Donnelly D. The structure and function of the glucagon-like peptide-1 receptor and its ligands. British Journal of Pharmacology. 166: 27-41. PMID 21950636 DOI: 10.1111/j.1476-5381.2011.01687.x |
0.432 |
|
2010 |
Mann RJ, Al-Sabah S, de Maturana RL, Sinfield JK, Donnelly D. Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket. Peptides. 31: 2289-93. PMID 20869417 DOI: 10.1016/j.peptides.2010.09.015 |
0.699 |
|
2010 |
Chapman KL, Kinsella GK, Cox A, Donnelly D, Findlay JB. Interactions of the melanocortin-4 receptor with the peptide agonist NDP-MSH. Journal of Molecular Biology. 401: 433-50. PMID 20600126 DOI: 10.1016/j.jmb.2010.06.028 |
0.783 |
|
2010 |
Miller PS, Barwell J, Poyner DR, Wigglesworth MJ, Garland SL, Donnelly D. Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74. Biochemical and Biophysical Research Communications. 391: 437-42. PMID 19914210 DOI: 10.1016/j.bbrc.2009.11.076 |
0.757 |
|
2010 |
Barwell J, Miller PS, Donnelly D, Poyner DR. Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptor. Peptides. 31: 170-6. PMID 19913063 DOI: 10.1016/j.peptides.2009.10.021 |
0.775 |
|
2008 |
Mann R, Wigglesworth MJ, Donnelly D. Ligand-receptor interactions at the parathyroid hormone receptors: subtype binding selectivity is mediated via an interaction between residue 23 on the ligand and residue 41 on the receptor. Molecular Pharmacology. 74: 605-13. PMID 18539702 DOI: 10.1124/mol.108.048017 |
0.818 |
|
2005 |
Ellis J, Warburton P, Donnelly D, Balmforth AJ. Conformational induction is the key process for activation of the AT1 receptor. Biochemical Pharmacology. 71: 464-71. PMID 16343447 DOI: 10.1016/j.bcp.2005.11.011 |
0.65 |
|
2005 |
Cox A, Donnelly D, Kaur M, Cheetham SC, Cockcroft VB, Findlay JB. MTSEA prevents ligand binding to the human melanocortin-4 receptor by modification of cysteine 130 in transmembrane helix 3. Febs Letters. 579: 285-91. PMID 15620728 DOI: 10.1016/j.febslet.2004.11.087 |
0.682 |
|
2004 |
López de Maturana R, Treece-Birch J, Abidi F, Findlay JB, Donnelly D. Met-204 and Tyr-205 are together important for binding GLP-1 receptor agonists but not their N-terminally truncated analogues. Protein and Peptide Letters. 11: 15-22. PMID 14965274 |
0.74 |
|
2004 |
Al-Sabah S, Donnelly D. The primary ligand-binding interaction at the GLP-1 receptor is via the putative helix of the peptide agonists. Protein and Peptide Letters. 11: 9-14. PMID 14965273 DOI: 10.2174/0929866043478365 |
0.85 |
|
2003 |
Al-Sabah S, Donnelly D. The positive charge at Lys-288 of the glucagon-like peptide-1 (GLP-1) receptor is important for binding the N-terminus of peptide agonists. Febs Letters. 553: 342-6. PMID 14572647 DOI: 10.1016/s0014-5793(03)01043-3 |
0.85 |
|
2003 |
Al-Sabah S, Donnelly D. A model for receptor-peptide binding at the glucagon-like peptide-1 (GLP-1) receptor through the analysis of truncated ligands and receptors. British Journal of Pharmacology. 140: 339-46. PMID 12970080 DOI: 10.1038/sj.bjp.0705453 |
0.857 |
|
2003 |
López de Maturana R, Willshaw A, Kuntzsch A, Rudolph R, Donnelly D. The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1. The Journal of Biological Chemistry. 278: 10195-200. PMID 12524435 DOI: 10.1074/jbc.M212147200 |
0.613 |
|
2002 |
López de Maturana R, Donnelly D. The glucagon-like peptide-1 receptor binding site for the N-terminus of GLP-1 requires polarity at Asp198 rather than negative charge. Febs Letters. 530: 244-8. PMID 12387900 DOI: 10.1016/s0014-5793(02)03492-0 |
0.549 |
|
Low-probability matches (unlikely to be authored by this person) |
2020 |
Poulter JA, Gravett MSC, Taylor RL, Fujinami K, De Zaeytijd J, Bellingham J, Rehman AU, Hayashi T, Kondo M, Rehman A, Ansar M, Donnelly D, Toomes C, Ali M, et al. New variants and in silico analyses in GRK1 associated Oguchi disease. Human Mutation. PMID 33252155 DOI: 10.1002/humu.24140 |
0.14 |
|
2004 |
Bond U, Neal C, Donnelly D, James TC. Aneuploidy and copy number breakpoints in the genome of lager yeasts mapped by microarray hybridisation. Current Genetics. 45: 360-70. PMID 15103502 DOI: 10.1007/s00294-004-0504-x |
0.01 |
|
Hide low-probability matches. |