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Ashleigh S Paparella - Publications

Affiliations: 
Albert Einstein College of Medicine, New York, New York, United States 
Area:
Enzymology, Enzyme Transition States, Enzyme Inhibitors, Antibiotics
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2/10 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Paparella AS, Cahill SM, Aboulache BL, Schramm VL. TcdB Toxin Glucosylates Rho GTPase by an S Mechanism and Ion Pair Transition State. Acs Chemical Biology. 17: 2507-2518. PMID 36038138 DOI: 10.1021/acschembio.2c00408  0.392
2021 Paparella AS, Aboulache BL, Harijan RK, Potts KS, Tyler PC, Schramm VL. Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues. Nature Communications. 12: 6285. PMID 34725358 DOI: 10.1038/s41467-021-26580-6  0.393
Low-probability matches (unlikely to be authored by this person)
2016 Feng J, Paparella AS, Booker GW, Polyak SW, Abell AD. Biotin Protein Ligase Is a Target for New Antibacterials. Antibiotics (Basel, Switzerland). 5. PMID 27463729 DOI: 10.3390/Antibiotics5030026  0.254
2015 Tieu W, Polyak SW, Paparella AS, Yap MY, Soares da Costa TP, Ng B, Wang G, Lumb R, Bell JM, Turnidge JD, Wilce MC, Booker GW, Abell AD. Improved Synthesis of Biotinol-5'-AMP: Implications for Antibacterial Discovery. Acs Medicinal Chemistry Letters. 6: 216-20. PMID 25699152 DOI: 10.1021/Ml500475N  0.228
2014 Paparella AS, Soares da Costa TP, Yap MY, Tieu W, Wilce MCJ, Booker GW, Abell AD, Polyak SW. Structure guided design of Biotin protein ligase inhibitors for antibiotic discovery Current Topics in Medicinal Chemistry. 14: 4-20. PMID 24236729 DOI: 10.2174/1568026613666131111103149  0.227
2019 Lee KJ, Tieu W, Blanco-Rodriguez B, Paparella AS, Yu J, Hayes A, Feng J, Marshall AC, Noll B, Milne R, Cini D, Wilce MCJ, Booker GW, Bruning JB, Polyak SW, et al. Sulfonamide-based inhibitors of biotin protein ligase as new antibiotic leads. Acs Chemical Biology. PMID 31407891 DOI: 10.1021/Acschembio.9B00463  0.204
2014 Tieu W, Jarrad AM, Paparella AS, Keeling KA, Soares da Costa TP, Wallace JC, Booker GW, Polyak SW, Abell AD. Heterocyclic acyl-phosphate bioisostere-based inhibitors of Staphylococcus aureus biotin protein ligase. Bioorganic & Medicinal Chemistry Letters. 24: 4689-93. PMID 25193234 DOI: 10.1016/J.Bmcl.2014.08.030  0.187
2016 Feng J, Paparella AS, Tieu W, Heim D, Clark S, Hayes A, Booker GW, Polyak SW, Abell AD. New Series of BPL Inhibitors To Probe the Ribose-Binding Pocket of Staphylococcus aureus Biotin Protein Ligase. Acs Medicinal Chemistry Letters. 7: 1068-1072. PMID 27994739 DOI: 10.1021/Acsmedchemlett.6B00248  0.183
2020 Hayes AJ, Satiaputra J, Sternicki LM, Paparella AS, Feng Z, Lee KJ, Rodriguez BB, Tieu W, Eijkelkamp BA, Shearwin KE, Pukala TL, Abell AD, Booker GW, Polyak SW. Advanced Resistance Studies Identify Two Discrete Mechanisms in to Overcome Antibacterial Compounds that Target Biotin Protein Ligase. Antibiotics (Basel, Switzerland). 9. PMID 32268615 DOI: 10.3390/Antibiotics9040165  0.181
2017 Paparella AS, Lee KJ, Hayes A, Feng J, Feng Z, Cini D, Deshmukh S, Booker GW, Wilce MCJ, Polyak SW, Abell AD. Halogenation of biotin protein ligase inhibitors improves whole cell activity against Staphylococcus aureus. Acs Infectious Diseases. PMID 29131575 DOI: 10.1021/Acsinfecdis.7B00134  0.169
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