| Year |
Citation |
Score |
| 2006 |
Hitchings GH, Elion GB. Some Aspects Of Immunosuppression Annals of the New York Academy of Sciences. 129: 799-803. DOI: 10.1111/J.1749-6632.1966.Tb12897.X |
0.644 |
|
| 2005 |
Kurtzberg J, Ernst TJ, Keating MJ, Gandhi V, Hodge JP, Kisor DF, Lager JJ, Stephens C, Levin J, Krenitsky T, Elion G, Mitchell BS. Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies Journal of Clinical Oncology. 23: 3396-3403. PMID 15908652 DOI: 10.1200/Jco.2005.03.199 |
0.328 |
|
| 2000 |
BALIS ME, LEVIN DH, BROWN GB, ELION GB, NATHAN HC, HITCHINGS G. The effects of 6-mercaptopurine on Lactobacillus casei. Archives of Biochemistry and Biophysics. 71: 358-66. PMID 13471038 DOI: 10.1016/0003-9861(57)90046-2 |
0.684 |
|
| 2000 |
Patel VJ, Elion GB, Houghton PJ, Keir S, Pegg AE, Johnson SP, Dolan ME, Bigner DD, Friedman HS. Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 6: 4154-7. PMID 11051270 |
0.261 |
|
| 2000 |
Castellino RC, Elion GB, Keir ST, Houghton PJ, Johnson SP, Bigner DD, Friedman HS. Schedule-dependent activity of irinotecan plus BCNU against malignant glioma xenografts. Cancer Chemotherapy and Pharmacology. 45: 345-9. PMID 10755324 DOI: 10.1007/S002800050050 |
0.355 |
|
| 1999 |
Elion GB, Furman PA, Fyfe JA, de Miranda P, Beauchamp L, Schaeffer HJ. The selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Reproduced from Proc. Natl. Acad. Sci. USA 74, 5716-5720 (1977) Reviews in Medical Virology. 9: 147-52; discussion 1. PMID 10479776 DOI: 10.1002/(Sici)1099-1654(199907/09)9:3<147::Aid-Rmv255>3.0.Co;2-P |
0.333 |
|
| 1999 |
Elion GB. Personal reflections Annals of the New York Academy of Sciences. 869: 16-18. DOI: 10.1111/j.1749-6632.1999.tb08350.x |
0.157 |
|
| 1998 |
Hanley ML, Elion GB, Colvin OM, Modrich PL, Keir S, Adams DJ, Bigner DD, Friedman HS. Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors. Cancer Chemotherapy and Pharmacology. 42: 479-82. PMID 9788574 DOI: 10.1007/S002800050848 |
0.349 |
|
| 1998 |
Coggins CA, Elion GB, Houghton PJ, Hare CB, Keir S, Colvin OM, Bigner DD, Friedman HS. Enhancement of irinotecan (CPT-11) activity against central nervous system tumor xenografts by alkylating agents. Cancer Chemotherapy and Pharmacology. 41: 485-90. PMID 9554593 DOI: 10.1007/s002800050771 |
0.28 |
|
| 1997 |
Hare CB, Elion GB, Colvin OM, Ali-Osman F, Griffith OW, Petros WP, Keir S, Marcelli SL, Bigner DD, Friedman HS. Characterization of the mechanisms of busulfan resistance in a human glioblastoma multiforme xenograft. Cancer Chemotherapy and Pharmacology. 40: 409-14. PMID 9272117 DOI: 10.1007/s002800050678 |
0.261 |
|
| 1997 |
Aarbakke J, Janka-Schaub G, Elion GB. Thiopurine biology and pharmacology Trends in Pharmacological Sciences. 18: 3-7. PMID 9114722 DOI: 10.1016/S0165-6147(96)01007-3 |
0.22 |
|
| 1997 |
Hare CB, Elion GB, Houghton PJ, Houghton JA, Keir S, Marcelli SL, Bigner DD, Friedman HS. Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against pediatric and adult central nervous system tumor xenografts. Cancer Chemotherapy and Pharmacology. 39: 187-91. PMID 8996518 DOI: 10.1007/S002800050558 |
0.361 |
|
| 1997 |
Moynihan K, Elion GB, Pegram C, Reist CJ, Wellner D, Bigner DD, Griffith OW, Friedman HS. L-amino acid oxidase (LOX) modulation of melphalan activity against intracranial glioma. Cancer Chemotherapy and Pharmacology. 39: 179-86. PMID 8996517 DOI: 10.1007/S002800050557 |
0.395 |
|
| 1996 |
Moynihan K, Elion GB, Ali-Osman F, Marcelli S, Keir S, Bigner DD, Friedman HS. Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta. Cancer Chemotherapy and Pharmacology. 38: 349-54. PMID 8674158 DOI: 10.1007/S002800050494 |
0.347 |
|
| 1995 |
Castellino SM, Friedman HS, Elion GB, Ong ET, Marcelli SL, Page R, Bigner DD, Dewhirst MW. Flunarizine enhancement of melphalan activity against drug-sensitive-resistant rhabdomyosarcoma British Journal of Cancer. 71: 1181-1187. PMID 7779708 DOI: 10.1038/Bjc.1995.230 |
0.342 |
|
| 1995 |
Rich JN, Elion GB, Wellner D, Colvin OM, Groothuis DR, Hilton JH, Schlageter KE, Bigner DD, Griffith OW, Friedman HS. The effect of L-amino acid oxidase on activity of melphalan against an intracranial xenograft. Cancer Chemotherapy and Pharmacology. 36: 379-84. PMID 7634379 DOI: 10.1007/Bf00686186 |
0.4 |
|
| 1994 |
Aaron RH, Elion GB, Colvin OM, Graham M, Keir S, Bigner DD, Friedman HS. Busulfan therapy of central nervous system xenografts in athymic mice Cancer Chemotherapy and Pharmacology. 35: 127-131. PMID 7987988 DOI: 10.1007/BF00686634 |
0.255 |
|
| 1993 |
Elion GB. The quest for a cure Annual Review of Pharmacology and Toxicology. 33: 1-23. PMID 8494337 DOI: 10.1146/Annurev.Pa.33.040193.000245 |
0.288 |
|
| 1993 |
Castellino S, Elion GB, Griffith OW, Dewhirst M, Kurtzberg J, Cattley RC, Scott P, Bigner DD, Friedman HS. Development of a model of melphalan-induced gastrointestinal toxicity in mice Cancer Chemotherapy and Pharmacology. 31: 376-380. PMID 8431971 DOI: 10.1007/Bf00686151 |
0.347 |
|
| 1993 |
Elion GB. The George Hitchings and Gertrude Elion Lecture. The pharmacology of azathioprine. Annals of the New York Academy of Sciences. 685: 400-407. PMID 8363248 DOI: 10.1111/J.1749-6632.1993.Tb35897.X |
0.341 |
|
| 1993 |
Elion GB. Acyclovir: discovery, mechanism of action, and selectivity. Journal of Medical Virology. 2-6. PMID 8245887 DOI: 10.1002/Jmv.1890410503 |
0.357 |
|
| 1993 |
Elion GB. The pharmacology of azathioprine Annals of the New York Academy of Sciences. 685: 401-407. |
0.236 |
|
| 1992 |
Laskowitz DT, Elion GB, Dewhirst MW, Griffith OW, Savina PM, Blum MR, Prescott DM, Bigner DD, Friedman HS. Hyperthermia-induced enhancement of melphalan activity against a melphalan-resistant human rhabdomyosarcoma xenograft. Radiation Research. 129: 218-23. PMID 1734453 |
0.246 |
|
| 1992 |
Laskowitz DT, Elion GB, Dewhirst MW, Griffith OW, Casero RA, Scott PA, Bullock N, Bigner DD, Friedman HS. Effects of glutathione or polyamine depletion on in vivo thermosensitization International Journal of Hyperthermia. 8: 199-208. PMID 1573309 DOI: 10.3109/02656739209021775 |
0.254 |
|
| 1992 |
Laskowitz DT, Elion GB, Dewhirst MW, Griffith OW, Cattley RC, Bigner DD, Friedman HS. Enhancement of melphalan-induced gastrointestinal toxicity in mice treated with regional hyperthermia and BSO-mediated glutathione depletion International Journal of Hyperthermia. 8: 111-120. PMID 1545157 DOI: 10.3109/02656739209052883 |
0.348 |
|
| 1992 |
Laskowitz DT, Elion GB, Dewhirst MW, Griffith OW, Savina PM, Blum MR, Prescott DM, Bigner DD, Friedman HS. Hyperthermia-Induced Enhancement of Melphalan Activity against a Melphalan-Resistant Human Rhabdomyosarcoma Xenograft Radiation Research. 129: 218-223. DOI: 10.2307/3578160 |
0.344 |
|
| 1991 |
Wang AM, Elion GB, Friedman HS, Bodell WJ, Bigner DD, Schold SC. Positive therapeutic interaction between thiopurines and alkylating drugs in human glioma xenografts Cancer Chemotherapy and Pharmacology. 27: 278-284. PMID 1998983 DOI: 10.1007/Bf00685112 |
0.358 |
|
| 1991 |
Elion GB. Kidney transplantation: Overlooked pioneer [3] Science. 251: 258. PMID 1987640 |
0.198 |
|
| 1991 |
Hebert ME, Greenberg ML, Chaffee S, Gravatt L, Hershfield MS, Elion GB, Kurtzberg J. Pharmacologic purging of malignant T cells from human bone marrow using 9-beta-D-arabinofuranosylguanine. Transplantation. 52: 634-40. PMID 1926342 DOI: 10.1097/00007890-199110000-00011 |
0.335 |
|
| 1991 |
Lilley ER, Elion GB, Dewhirst MW, Schold SC, Blum MR, Savina PM, Laskowitz DT, Bigner DD, Friedman HS. Therapeutic analysis of melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR Cancer Research. 51: 3906-3909. PMID 1855207 |
0.23 |
|
| 1991 |
Elion GB. Kidney Transplantation: Overlooked Pioneer Science. 251: 258-258. DOI: 10.1126/Science.251.4991.258-A |
0.312 |
|
| 1990 |
Lilley ER, Rosenberg MC, Elion GB, Colvin OM, Bigner DD, Friedman HS. Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft Cancer Research. 50: 284-287. PMID 2295068 |
0.254 |
|
| 1989 |
Friedman HS, Colvin OM, Griffith OW, Lippitz B, Elion GB, Schold SC, Hilton J, Bigner DD. Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion Journal of the National Cancer Institute. 81: 524-527. PMID 2921776 DOI: 10.1093/jnci/81.7.524 |
0.261 |
|
| 1989 |
Elion GB. The purine path to chemotherapy Bioscience Reports. 9: 509-529. PMID 2679902 DOI: 10.1007/Bf01119794 |
0.353 |
|
| 1989 |
Elion GB. Nobel lecture in physiology or medicine--1988. The purine path to chemotherapy. In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association. 25: 321-30. PMID 2654122 DOI: 10.1007/Bf02624593 |
0.319 |
|
| 1989 |
Elion GB. The purine path to chemotherapy. Science (New York, N.Y.). 244: 41-7. PMID 2649979 DOI: 10.1126/Science.2649979 |
0.353 |
|
| 1989 |
Rosenberg MC, Colvin OM, Griffith OW, Bigner SH, Elion GB, Horton JK, Lilley E, Bigner DD, Friedman HS. Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion. Cancer Research. 49: 6917-22. PMID 2582434 |
0.221 |
|
| 1989 |
Elion GB. The Purine Path to Chemotherapy (Nobel Lecture) Angewandte Chemie. 28: 870-878. DOI: 10.1002/Anie.198908701 |
0.314 |
|
| 1989 |
Elion GB. Der Purin-Weg zur Chemotherapie (Nobel-Vortrag) Angewandte Chemie. 101: 893-902. DOI: 10.1002/Ange.19891010706 |
0.314 |
|
| 1989 |
Elion GB. The public path to chemotherapy Angewandte Chemie - International Edition in English. 28: 870-878. |
0.184 |
|
| 1988 |
Friedman HS, Skapek SX, Colvin OM, Elion GB, Blum MR, Savina PM, Hilton J, Schold SC, Kurtzberg J, Bigner DD. Melphalan transport, glutathione levels, and glutathione-S-transferase activity in human medulloblastoma Cancer Research. 48: 5397-5402. PMID 3416297 |
0.272 |
|
| 1988 |
Friedman HS, Colvin OM, Skapek SX, Ludeman SM, Elion GB, Schold SC, Jacobsen PF, Muhlbaier LH, Bigner DD. Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents Cancer Research. 48: 4189-4195. PMID 3390813 |
0.288 |
|
| 1988 |
Skapek SX, Colvin OM, Griffith OW, Elion GB, Bigner DD, Friedman HS. Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice Cancer Research. 48: 2764-2767. PMID 3359437 |
0.255 |
|
| 1988 |
Skapek SX, Colvin OM, Griffith OW, Groothuis DR, Colapinto EV, Lee Y, Hilton J, Elion GB, Bigner DD, Friedman HS. Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts. Biochemical Pharmacology. 37: 4313-7. PMID 3196356 DOI: 10.1016/0006-2952(88)90612-0 |
0.371 |
|
| 1986 |
Elion GB. Historical background of 6-mercaptopurine Toxicology and Industrial Health. 2: 1-9. PMID 3538499 DOI: 10.1177/074823378600200201 |
0.286 |
|
| 1985 |
Dranoff G, Elion GB, Friedman HS, Bigner DD. Combination chemotherapy in vitro exploiting glutamine metabolism of human glioma and medulloblastoma Cancer Research. 45: 4082-4086. PMID 4028000 |
0.273 |
|
| 1985 |
Elion GB. An overview of the role of nucleosides in chemotherapy Advances in Enzyme Regulation. 24: 323-334. PMID 3915187 DOI: 10.1016/0065-2571(85)90084-6 |
0.377 |
|
| 1985 |
Elion GB. Selectivity - Key to chemotherapy: Presidential adress Cancer Research. 45: 2943-2950. PMID 3891079 |
0.207 |
|
| 1985 |
Hitchings GH, Elion GB. Layer on layer: The Bruce F. Cain Memorial Award Lecture Cancer Research. 45: 2415-2420. PMID 3886133 |
0.603 |
|
| 1985 |
Dranoff G, Elion GB, Friedman HS, Campbell GL, Bigner DD. Influence of glutamine on the growth of human glioma and medulloblastoma in culture Cancer Research. 45: 4077-4081. PMID 2862994 |
0.297 |
|
| 1985 |
Dranoff G, Elion GB, Friedman HS, Bigner DD. Glutamine based combination chemotherapy in culture for human glioma and medulloblastoma Proceedings of the American Association For Cancer Research. No. 1273. |
0.221 |
|
| 1984 |
Nelson DJ, Elion GB. Metabolic studies of high doses of allopurinol in humans. Advances in Experimental Medicine and Biology. 165: 167-170. PMID 6720373 DOI: 10.1007/978-1-4684-4553-4_31 |
0.35 |
|
| 1984 |
Rundles RW, Elion GB. Mercaptopurine 'bioavailability' New England Journal of Medicine. 310: 929. PMID 6583508 |
0.217 |
|
| 1984 |
McGuirt PV, Shaw JE, Elion GB, Furman PA. Identification of small DNA fragments synthesized in herpes simplex virus-infected cells in the presence of acyclovir Antimicrobial Agents and Chemotherapy. 25: 507-509. PMID 6329081 DOI: 10.1128/Aac.25.4.507 |
0.338 |
|
| 1984 |
Dranoff G, Elion GB, Campbell GL, Friedman HS, Bigner PP. 130 Influence Of Glutamine On Growth Of Human Medulloblastoma In Culture Journal of Neuropathology and Experimental Neurology. 43: 336. DOI: 10.1097/00005072-198405000-00136 |
0.319 |
|
| 1984 |
RIDEAOUT JL, KRENITSKY TA, CHAO EY, ELION GB, WILLIAMS RB, LATTER VS. ChemInform Abstract: Pyrazolo[3,4»d]pyrimidine Ribonucleosides as Anticoccidials. Part 3. Synthesis and Activity of Some Nucleosides of 4-[(Arylalkenyl)thio]pyrazolo[3,4-d]pyrimidines. Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198413344 |
0.291 |
|
| 1983 |
Tucker WE, Krasny HC, de Miranda P, Goldenthal EI, Elion GB, Hajian G, Szczech GM. Preclinical toxicology studies with acyclovir: carcinogenicity bioassays and chronic toxicity tests. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 3: 579-86. PMID 6662300 DOI: 10.1016/S0272-0590(83)80108-0 |
0.336 |
|
| 1983 |
Tucker WE, Macklin AW, Szot RJ, Johnston RE, Elion GB, de Miranda P, Szczech GM. Preclinical toxicology studies with acyclovir: acute and subchronic tests. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 3: 573-8. PMID 6662299 DOI: 10.1016/S0272-0590(83)80107-9 |
0.336 |
|
| 1983 |
Tucker WE, Johnston RE, Macklin AW, Szot RJ, Elion GB, de Miranda P, Szczech GM. Preclinical toxicology studies with acyclovir: ophthalmic and cutaneous tests. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 3: 569-72. PMID 6662298 DOI: 10.1016/S0272-0590(83)80106-7 |
0.344 |
|
| 1983 |
Good SS, Krasny HC, Elion GB, De Miranda P. Disposition of the dog and the rat of 2,6-diamino-9-(2-hydroxyethoxymethyl)purine (A134U), a potential prodrug of acyclovir Journal of Pharmacology and Experimental Therapeutics. 227: 644-651. PMID 6655561 |
0.231 |
|
| 1983 |
Tuttle JV, Krenitsky TA, Elion GB. Effects of acyclovir and its metabolites on hypoxanthine-guanine phosphoribosyltransferase Biochemical Pharmacology. 32: 3011-3015. PMID 6639669 DOI: 10.1016/0006-2952(83)90242-3 |
0.387 |
|
| 1983 |
Rideout JL, Krenitsky TA, Chao EY, Elion GB, Williams RB, Latter VS. Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 3. Synthesis and activity of some nucleosides of 4-[(arylalkenyl)thio]pyrazolo[3,4-d]pyrimidines Journal of Medicinal Chemistry. 26: 1489-1494. PMID 6620308 DOI: 10.1002/Chin.198413344 |
0.363 |
|
| 1983 |
Elion GB. The biochemistry and mechanism of action of acyclovir Journal of Antimicrobial Chemotherapy. 12: 9-17. PMID 6313600 DOI: 10.1093/Jac/12.Suppl_B.9 |
0.367 |
|
| 1983 |
Kucera LS, Furman PA, Elion GB. Inhibition by acyclovir of herpes simplex virus type 2 morphologically transformed cell growth in tissue culture and tumor-bearing animals Journal of Medical Virology. 12: 119-127. PMID 6311971 DOI: 10.1002/Jmv.1890120206 |
0.354 |
|
| 1983 |
Averett DR, Lubbers C, Elion GB, Spector T. Ribonucleotide reductase induced by herpes simplex type 1 virus. Characterization of a distinct enzyme. Journal of Biological Chemistry. 258: 9831-9838. PMID 6309786 |
0.261 |
|
| 1983 |
Tucker WE, Krasny HC, De Miranda P, Goldenthal EI, Elion GB, Hajian G, Szczech GM. Preclinical toxicology studies with acyclovir: Carcinogenicity bioassays and chronic toxicity tests Toxicological Sciences. 3: 579-586. DOI: 10.1093/toxsci/3.6.579 |
0.2 |
|
| 1983 |
Tucker WE, Macklin AW, Szot RJ, Johnston RE, Elion GB, De Miranda P, Szczech GM. Preclinical toxicology studies with acyclovir: Acute and subchronic tests Toxicological Sciences. 3: 573-578. DOI: 10.1093/toxsci/3.6.573 |
0.188 |
|
| 1983 |
Tucker WE, Johnston RE, Macklin AW, Szot RJ, Elion GB, De Miranda P, Szczech GM. Preclinical toxicology studies with acyclovir: Ophthalmic and cutaneous tests Toxicological Sciences. 3: 569-572. DOI: 10.1093/toxsci/3.6.569 |
0.198 |
|
| 1983 |
Rideout JL, Krenitsky TA, Koszalka GW, Cohn NK, Chao EY, Elion GB, Latter VS, Williams RB. Pyrazolo(3,4-D)Pyrimidine Ribonucleosides As Anticoccidials. 2. Synthesis And D Activity Of Some Nucleosides Of 4-(Alkylamino)-1H-Pyrazolo(3,4-D)Pyrimidines Cheminform. 14. DOI: 10.1002/Chin.198305340 |
0.356 |
|
| 1982 |
Medzihradsky JL, Zimmerman TP, Wolberg G, Elion GB. Immunosuppressive effects of the S-adenosylhomocysteine hydrolase inhibitor, 3-deazaadenosine Journal of Immunopharmacology. 4: 29-41. PMID 7153525 DOI: 10.3109/08923978209031073 |
0.253 |
|
| 1982 |
Rideout JL, Krenitsky TA, Koszalka GW, Cohn NK, Chao EY, Elion GB, Latter VS, Williams RB. Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 2. Synthesis and activity of some nucleosides of 4-(alkylamino)-1H-pyrazolo[3, 4-d]pyrimidines. Journal of Medicinal Chemistry. 25: 1040-4. PMID 7131482 DOI: 10.1021/Jm00351A007 |
0.374 |
|
| 1982 |
Miranda Pd, Krasny HC, Page DA, Elion GB. Species differences in the disposition of acyclovir The American Journal of Medicine. 73: 31-35. PMID 7102710 DOI: 10.1016/0002-9343(82)90059-6 |
0.347 |
|
| 1982 |
Krenitsky TA, Rideout JL, Koszalka GW, Inmon RB, Chao EY, Elion GB, Latter VS, Williams RB. Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 1. Synthesis and activity of some nucleosides of purines and 4-(alkylthio)pyrazolo[3,4-d]pyrimidines Journal of Medicinal Chemistry. 25: 32-35. PMID 7086819 DOI: 10.1021/Jm00343A007 |
0.361 |
|
| 1982 |
Biron KK, Noblin JE, De Miranda P, Elion GB. Uptake, distribution, and anabolism of acyclovir in herpes simplex virus-infected mice Antimicrobial Agents and Chemotherapy. 21: 44-50. PMID 7081975 |
0.231 |
|
| 1982 |
Marr JJ, Berens RL, Nelson DJ, Krenitsky TA, Spector T, LaFon SW, Elion GB. Antileishmanial action of 4-thiopyrazolo (3,4-d)pyrimidine and its ribonucleoside. Biological effects and metabolism Biochemical Pharmacology. 31: 143-148. PMID 7073876 DOI: 10.1016/0006-2952(82)90203-9 |
0.4 |
|
| 1982 |
Quinn RP, Wolberg G, Medzihradsky J, Elion GB. Effect of acyclovir on various murine in vivo and in vitro immunologic assay systems The American Journal of Medicine. 73: 62-66. PMID 7048924 DOI: 10.1016/0002-9343(82)90065-1 |
0.364 |
|
| 1982 |
Elion GB. Mechanism of action and selectivity of acyclovir The American Journal of Medicine. 73: 7-13. PMID 6285736 DOI: 10.1016/0002-9343(82)90055-9 |
0.368 |
|
| 1982 |
Fyfe JA, Biron KK, McKee SA, Kelly CM, Elion GB, Soike KF. Activation and antiviral effect of acyclovir in cells infected with a varicella-like simian virus The American Journal of Medicine. 73: 58-61. PMID 6285734 DOI: 10.1016/0002-9343(82)90064-X |
0.353 |
|
| 1982 |
Biron KK, Elion GB. Effect of acyclovir combined with other antiherpetic agents on varicella zoster virus in vitro The American Journal of Medicine. 73: 54-57. PMID 6285733 DOI: 10.1016/0002-9343(82)90063-8 |
0.371 |
|
| 1982 |
Biron KK, Fyfe JA, Noblin JE, Elion GB. Selection and preliminary characterization of acyclovir-resistant mutants of varicella zoster virus The American Journal of Medicine. 73: 383-386. PMID 6285728 DOI: 10.1016/0002-9343(82)90128-0 |
0.357 |
|
| 1982 |
McGuirt PV, Keller PM, Elion GB. A radioimmunoassay for Herpes Simplex Virus (HSV) thymidine kinase Virology. 116: 489-498. PMID 6278724 DOI: 10.1016/0042-6822(82)90142-8 |
0.341 |
|
| 1982 |
Elion GB, Williams TE, Berken A. Allopurinol-induced suppressor T cell dysfunction Journal of the American Academy of Dermatology. 7: 687-688. PMID 6216274 |
0.191 |
|
| 1982 |
Medzihradsky JL, Klein C, Elion GB. Differential interference by azathioprine and 6-mercaptopurine with antibody-mediated immunoregulation: Synergism of azathioprine and antibody in the control of an immune response Journal of Immunology. 129: 145-149. PMID 6177747 |
0.226 |
|
| 1982 |
Krenitsky TA, Rideout JL, Koszalka GW, Inmon RB, Chao EY, Elion GB, Latter VS, Williams RB. Pyrazolo(3,4-D)Pyrimidine Ribonucleosides As Anticoccidials. 1. Synthesis And D Activity Of Some Nucleosides Of Purines And 4-(Alkylthio)Pyrazolo(3,4-D)Pyrimidines Cheminform. 13. DOI: 10.1002/Chin.198228324 |
0.358 |
|
| 1982 |
Medzihradsky JL, Elion GB. Suppression of antibody-dependent cellular effector functions by the S-adenosylhomocysteine hydrolase inhibitor, 3-deazaadenosine: Potentiation of the effect by L-homocysteine thiolactone International Journal of Immunopharmacology. 4: 359. |
0.228 |
|
| 1981 |
Krasny HC, De Miranda P, Blum MR, Elion GB. Pharmacokinetics and bioavailability of acyclovir in the dog Journal of Pharmacology and Experimental Therapeutics. 216: 281-288. PMID 7463350 |
0.236 |
|
| 1981 |
Miranda de P, Krasn HC, Page DA, Elion GB. The disposition of acyclovir in different species Journal of Pharmacology and Experimental Therapeutics. 219: 309-315. PMID 7288622 |
0.247 |
|
| 1981 |
Medzihradsky JL, Hollowell RP, Elion GB. Differential inhibition by azathioprine and 6-mercaptopurine of specific suppressor T cell generation in mice. Journal of Immunopharmacology. 3: 1-16. PMID 6454729 |
0.246 |
|
| 1981 |
Furman PA, De Miranda P, St. Clair MH, Elion GB. Metabolism of acyclovir in virus-infected and uninfected cells Antimicrobial Agents and Chemotherapy. 20: 518-524. PMID 6282196 |
0.253 |
|
| 1981 |
Keller PM, Fyfe JA, Beauchamp L, Lubbers CM, Furman PA, Schaeffer HJ, Elion GB. Enzymatic phosphorylation of acyclic nucleoside analogs and correlations with antiherpetic activities Biochemical Pharmacology. 30: 3071-3077. PMID 6279102 DOI: 10.1016/0006-2952(81)90495-0 |
0.384 |
|
| 1981 |
Derse D, Cheng YC, Furman PA, St Clair MH, Elion GB. Inhibition of purified human and herpes simplex virus-induced DNA polymerases by 9-(2-hydroxyethoxymethyl)guanine triphosphate. Effects on primer-template function. Journal of Biological Chemistry. 256: 11447-11451. PMID 6271750 |
0.24 |
|
| 1981 |
Colby BM, Furman PA, Shaw JE, Elion GB, Pagano JS. Phosphorylation of acyclovir [9-(2-hydroxyethoxymethyl)guanine] in Epstein-Barr virus-infected lymphoblastoid cell lines Journal of Virology. 38: 606-611. PMID 6264131 |
0.227 |
|
| 1981 |
Medzihradsky JL, Hollowell RP, Elion GB. Differential inhibition by azathioprine and 6-mercaptopurine of specific suppressor t cell generation in mice Immunopharmacology and Immunotoxicology. 3: 1-16. DOI: 10.3109/08923978109026415 |
0.226 |
|
| 1981 |
Krenitsky TA, Koszalka GW, Tuttle JV, Rideout JL, Elion GB. An enzymic synthesis of purine d-Arabinonucleosides Carbohydrate Research. 97: 139-146. DOI: 10.1016/S0008-6215(00)80531-5 |
0.367 |
|
| 1980 |
Elion GB, Benezra FM, Beardmore TD, Kelley WN. Studies with allopurinol in patients with impaired renal function. Advances in Experimental Medicine and Biology. 122: 263-7. PMID 7424645 DOI: 10.1007/978-1-4615-9140-5_43 |
0.368 |
|
| 1980 |
Zimmerman TP, Wolberg G, Duncan GS, Elion GB. Adenosine analogues as substrates and inhibitors of S-Adenosylhomocysteine Hydrolase in intact lymphocytes Biochemistry. 19: 2252-2259. PMID 7378359 DOI: 10.1021/Bi00551A040 |
0.368 |
|
| 1980 |
Clair St. MH, Furman PA, Lubbers CM, Elion GB. Inhibition of cellular α and virally induced deoxyribonucleic acid polymerases by the triphosphate of acyclovir Antimicrobial Agents and Chemotherapy. 18: 741-745. PMID 7192534 DOI: 10.1128/Aac.18.5.741 |
0.365 |
|
| 1980 |
Elion GB. The chemotherapeutic exploitation of virus-specified enzymes Advances in Enzyme Regulation. 18: 53-66. PMID 6255770 DOI: 10.1016/0065-2571(80)90008-4 |
0.375 |
|
| 1980 |
Zimmerman TP, Schmitges CJ, Wolberg G, Deeprose RD, Duncan GS, Cuatrecasas P, Elion GB. Modulation of cyclic AMP metabolism by S-adenosylhomocysteine and S-3-deazaadenosylhomocysteine in mouse lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 77: 5639-43. PMID 6255458 DOI: 10.1073/Pnas.77.10.5639 |
0.379 |
|
| 1980 |
Biron KK, Elion GB. In vitro susceptibility of varicella-zoster virus to acyclovir Antimicrobial Agents and Chemotherapy. 18: 443-447. PMID 6252836 |
0.258 |
|
| 1980 |
Colby BM, Shaw JE, Elion GB, Pagano JS. Effect of acyclovir [9-(2-hydroxyethoxymethyl)guanine] on Epstein-Barr virus DNA replication Journal of Virology. 34: 560-568. PMID 6246281 |
0.243 |
|
| 1980 |
Furman PA, McGuirt PV, Keller PM, Fyfe JA, Elion GB. Inhibition by acyclovir of cell growth and DNA synthesis of cells biochemically transformed with Herpesvirus genetic information Virology. 102: 420-430. PMID 6245517 DOI: 10.1016/0042-6822(80)90109-9 |
0.354 |
|
| 1979 |
Nelson DJ, LaFon SW, Elion GB, Marr JJ, Berens RL. Comparative metabolism of a new antileishmanial agent, allopurinol riboside, in the parasite and the host cell. Advances in Experimental Medicine and Biology. 122: 7-12. PMID 546162 DOI: 10.1007/978-1-4684-8559-2_2 |
0.338 |
|
| 1979 |
Nelson DJ, LaFon SW, Tuttle JV, Miller WH, Miller RL, Krenitsky TA, Elion GB, Berens RL, Marr JJ. Allopurinol ribonucleoside as an antileishmanial agent. Biological effects, metabolism, and enzymatic phosphorylation Journal of Biological Chemistry. 254: 11544-11549. PMID 500658 |
0.253 |
|
| 1979 |
Spector T, Jones TE, Elion GB. Specificity of adenylosuccinate synthetase and adenylosuccinate lyase from Leishmania donovani. Selective amination of an antiprotozoal agent Journal of Biological Chemistry. 254: 8422-8426. PMID 468834 |
0.236 |
|
| 1979 |
Field HJ, Bell SE, Elion GB, Nash AA, Wildy P. Effect of acycloguanosine treatment on acute and latent herpes simplex infections in mice Antimicrobial Agents and Chemotherapy. 15: 554-561. PMID 464587 DOI: 10.1128/Aac.15.4.554 |
0.342 |
|
| 1979 |
Nelson DJ, Bugge CJL, Elion GB, Berens RL, Marr JJ. Metabolism of pyrazolo(3,4-d)pyrimidines in Leishmania braziliensis and Leishmania donovani. Allopurinol, oxipurinol, and 4-aminopyrazolo(3,4-d)pyrimidine Journal of Biological Chemistry. 254: 3959-3964. PMID 438170 |
0.278 |
|
| 1979 |
Furman PA, St Clair MH, Fyfe JA, Rideout JL, Keller PM, Elion GB. Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate Journal of Virology. 32: 72-77. PMID 232189 |
0.261 |
|
| 1979 |
de Miranda P, Whitley RJ, Blum MR, Keeney RE, Barton N, Cocchetto DM, Good S, Hemstreet GP, Kirk LE, Page DA, Elion GB. Acyclovir kinetics after intravenous infusion. Clinical Pharmacology and Therapeutics. 26: 718-28. PMID 227639 |
0.245 |
|
| 1979 |
Miller RL, Adamczyk DL, Miller WH, Koszalka GW, Rideout JL, Beacham LM, Chao EY, Haggerty JJ, Krenitsky TA, Elion GB. Adenosine kinase from rabbit liver. II. Substrate and inhibitor specificity. The Journal of Biological Chemistry. 254: 2346-52. PMID 218934 |
0.22 |
|
| 1979 |
Krenitsky TA, Koszalka GW, Tuttle JV, Adamczyk DL, Elion GB, Marr JJ. Purine salvage enzymes in man and Leishmania donovani. Advances in Experimental Medicine and Biology. 122: 51-56. PMID 121040 DOI: 10.1007/978-1-4684-8559-2_10 |
0.347 |
|
| 1979 |
Hollowell RP, Medzihradsky JL, Elion GB. Differential effects of 6-mercaptopurine and azathioprine on suppressor cells Federation Proceedings. 38: No.1960. |
0.209 |
|
| 1979 |
Krasny HC, De Miranda P, Blum MR, Elion GB. Pharmacokinetics and bioavailability of 9-(2-hydroxyethoxymethyl)guanine (BW 248U) in beagle dogs Federation Proceedings. 38: No. 1883. |
0.192 |
|
| 1978 |
Fyfe JA, Keller PM, Furman PA, Miller RL, Elion GB. Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine. The Journal of Biological Chemistry. 253: 8721-7. PMID 214430 |
0.222 |
|
| 1978 |
Zimmerman TP, Wolberg G, Duncan GS, Rideout JL, Beacham LM, Krenitsky TA, Elion GB. Inhibition of lymphocyte-mediated cytolysis by 2-fluoroadenosine--evidence for two discrete mechanisms of drug action. Biochemical Pharmacology. 27: 1731-7. PMID 213077 DOI: 10.1016/0006-2952(78)90549-X |
0.336 |
|
| 1978 |
Wolberg G, Zimmerman TP, Duncan GS, Singer KH, Elion GB. Inhibition of lymphocyte-mediated cytolysis by adenosine analogs. Biochemical studies concerning mechanism of action. Biochemical Pharmacology. 27: 1487-95. PMID 212072 DOI: 10.1016/0006-2952(78)90105-3 |
0.406 |
|
| 1978 |
Schaeffer HJ, Beauchamp L, de Miranda P, Elion GB, Bauer DJ, Collins P. 9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group. Nature. 272: 583-5. PMID 205792 DOI: 10.1038/272583A0 |
0.348 |
|
| 1977 |
Elion GB. Pharmacologic and physical agents. Immunosuppressive agents. Transplantation Proceedings. 9: 975-9. PMID 325831 |
0.208 |
|
| 1977 |
Elion GB, Furman PA, Fyfe JA, de Miranda P, Beauchamp L, Schaeffer HJ. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Proceedings of the National Academy of Sciences of the United States of America. 74: 5716-20. PMID 202961 DOI: 10.1073/Pnas.74.12.5716 |
0.374 |
|
| 1976 |
Krenitsky TA, Tuttle JV, Koszalka GW, Chen IS, Beacham LM, Rideout JL, Elion GB. Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity. The Journal of Biological Chemistry. 251: 4055-61. PMID 932021 |
0.254 |
|
| 1976 |
Zimmerman TP, Rideout JL, Wolberg G, Duncan GS, Elion GB. 2-Fluoroadenosine 3':5'-monophosphate. A metabolite of 2-fluoroadenosine in mouse cytotoxic lymphocytes. The Journal of Biological Chemistry. 251: 6757-66. PMID 185217 |
0.219 |
|
| 1975 |
de Miranda P, Beacham LM, Creagh TH, Elion GB. The metabolic disposition of 14C-azathioprine in the dog. The Journal of Pharmacology and Experimental Therapeutics. 195: 50-7. PMID 1181404 |
0.276 |
|
| 1975 |
Rodnan GP, Robin JA, Tolchin SF, Elion GB. Allopurinol and Gouty Hyperuricemia: Efficacy of a Single Daily Dose Jama: the Journal of the American Medical Association. 231: 1143-1147. PMID 1172813 DOI: 10.1001/jama.1975.03240230017012 |
0.219 |
|
| 1975 |
Nelson DJ, Elion GB. Metabolism of (6-14-c)allopurinollack of incorporation of allopurinol into nucleic acids. Biochemical Pharmacology. 24: 1235-7. PMID 1137609 DOI: 10.1016/0006-2952(75)90069-6 |
0.385 |
|
| 1975 |
Elion GB, Rideout JL, de Miranda P, Collins P, Bauer DJ. Biological activities of some purine arabinosides. Annals of the New York Academy of Sciences. 255: 468-80. PMID 171996 DOI: 10.1111/J.1749-6632.1975.Tb29251.X |
0.337 |
|
| 1974 |
Elion GB, Nelson DJ. Ribonucleotides of allopurinol and oxipurinol in rat tissues and their significance in purine metabolism Advances in Experimental Medicine and Biology. 41: 639-652. PMID 4832590 DOI: 10.1007/978-1-4757-1433-3_34 |
0.387 |
|
| 1974 |
Zimmerman TP, Chu LC, Bugge CJL, Nelson DJ, Lyon GM, Elion GB. Identification of 6 methylmercaptopurine ribonucleoside 5' diphosphate and 5' triphosphate as metabolites of 6 mercaptopurine in man Cancer Research. 34: 221-224. PMID 4520420 |
0.249 |
|
| 1974 |
Zimmerman TP, Li-Chiang C, Buggé CJL, Nelson DJ, Miller RL, Elion GB. Formation of 5′-nucleotides of 6-methylmercaptopurine ribonucleoside in human tissues in vitro Biochemical Pharmacology. 23: 2737-2749. PMID 4370717 DOI: 10.1016/0006-2952(74)90044-6 |
0.374 |
|
| 1974 |
Elion GB. Drugs in the treatment of hyperuricemia Advances in Nephrology From the Necker Hospital. 3: 51-57. PMID 4219708 |
0.196 |
|
| 1974 |
Miller RL, Adamczyk DL, Fyfe JA, Elion GB. Xanthine phosphoribosyltransferase from Streptococcus faecalis. Properties and specificity Archives of Biochemistry and Biophysics. 165: 349-358. PMID 4216296 DOI: 10.1016/0003-9861(74)90173-8 |
0.365 |
|
| 1974 |
YOEWELL HN, ELION GB. ChemInform Abstract: SYNTHESIS OF 6-(1-METHYL-4-NITRO-5-(4,5(14)C)IMIDAZOLYL)THIOPURINE (AZATHIOPRINE) Chemischer Informationsdienst. 5: no-no. DOI: 10.1002/chin.197428337 |
0.245 |
|
| 1974 |
De Miranda P, Beacham LM, Elion GB. Biotransformation of 14C azathioprine (imuran) in the dog Pharmacologist. 16: 035. |
0.192 |
|
| 1973 |
De Miranda P, Beacham LM, Creagh TH, Elion GB. The metabolic fate of the methylnitroimidazole moiety of azathioprine in the rat Journal of Pharmacology and Experimental Therapeutics. 187: 588-601. PMID 4770400 |
0.222 |
|
| 1973 |
Nelson DJ, Buggé CJL, Krasny HC, Elion GB. Formation of nucleotides of [6-14C]allopurinol and [6-14C]oxipurinol in rat tissues and effects on uridine nucleotide pools Biochemical Pharmacology. 22: 2003-2022. PMID 4353669 DOI: 10.1016/0006-2952(73)90082-8 |
0.364 |
|
| 1973 |
Yrowell HN, Elion GB. Synthesis of 6(1‐Methyl‐4‐nitro‐5‐|4,5‐14 C| imidazolyl)thiopurinc (azathioprine) Journal of Heterocyclic Chemistry. 10: 1017-1019. DOI: 10.1002/Jhet.5570100625 |
0.346 |
|
| 1973 |
Elion GB, Nelson DJ. Quantitative determination of ribonucleotides of allopurinol and oxipurinol in rat tissues and their significance in purine metabolism Israel Journal of Medical Sciences. 9: 1090. |
0.223 |
|
| 1973 |
Elion GB. Drug therapy of hyperuricemia | TRAITEMENT MEDICAMENTEUX DE L'HYPERURICEMIE Actualites Nephrologiques De L'Hopital Necker. 51-57. |
0.199 |
|
| 1973 |
Yeowell HN, Elion GB. Synthesis of 6 (1 methyl 4 nitro 5 [4,5 14C]imidazolyl)thiopurine (azathioprine) Journal of Heterocyclic Chemistry. 10: 1017-1019. |
0.242 |
|
| 1973 |
Nelson DJ, Bugge CJ, Krasny HC, Elion GB. Nucleotide derivatives of allopurinol and effect of uridine nucleotide metabolism Federation Proceedings. 32: 1641. |
0.267 |
|
| 1972 |
Elion GB. Significance of azathioprine metabolites Proceedings of the Royal Society of Medicine. 65: 257-260. PMID 5083313 DOI: 10.1177/003591577206500315 |
0.35 |
|
| 1972 |
Krenitsky TA, Neil SM, Elion GB, Hitchings GH. A comparison of the specificities of xanthine oxidase and aldehyde oxidase. Archives of Biochemistry and Biophysics. 150: 585-99. PMID 5044040 DOI: 10.1016/0003-9861(72)90078-1 |
0.673 |
|
| 1972 |
Yü TF, Balis ME, Krenitsky TA, Dancis J, Silvers DN, Elion GB, Gutman AB. Rarity of X-linked partial hypoxanthine-guanine phosphoribosyltransferase deficiency in a large gouty population Annals of Internal Medicine. 76: 255-264. PMID 5009592 DOI: 10.7326/0003-4819-76-2-255 |
0.34 |
|
| 1972 |
Massey V, Edmondson D, Palmer G, Beacham LM, Elion GB. The separation of functional and non-functional xanthine oxidase by affinity chromatography. The Biochemical Journal. 127: 10P-11P. PMID 4672853 DOI: 10.1042/Bj1270010P |
0.301 |
|
| 1972 |
Miller RL, Ramsey GA, Krenitsky TA, Elion GB. Guanine phosphoribosyltransferase from Escherichia coli, specificity and propertiest Biochemistry. 11: 4723-4731. PMID 4347700 DOI: 10.1021/Bi00775A014 |
0.311 |
|
| 1972 |
Edmondson D, Massey V, Palmer G, Beacham LM, Elion GB. The resolution of active and inactive xanthine oxidase by affinity chromatography. The Journal of Biological Chemistry. 247: 1597-604. PMID 4335003 |
0.217 |
|
| 1970 |
Massey V, Komai H, Palmer G, Elion GB. On the mechanism of inactivation of xanthine oxidase by allopurinol and other pyrazolo[3,4-d]pyrimidines. The Journal of Biological Chemistry. 245: 2837-44. PMID 5467924 |
0.231 |
|
| 1970 |
Massey V, Komai H, Palmer G, Elion GB. The existence of nonfunctional active sites in milk xanthine oxidase: reaction with functional active site inhibitors. Vitamins and Hormones. 28: 505-31. PMID 4335890 DOI: 10.1016/S0083-6729(08)60909-7 |
0.348 |
|
| 1969 |
Krenitsky TA, Papaioannou R, Elion GB. Human hypoxanthine phosphoribosyltransferase. I. Purification, properties, and specificity Journal of Biological Chemistry. 244: 1263-1270. PMID 5767308 |
0.21 |
|
| 1969 |
Elion GB. Actions of purine analogs: enzyme specificity studies as a basis for interpretation and design Cancer Research. 29: 2448-2453. PMID 4984034 |
0.229 |
|
| 1969 |
Elion GB, Blancuzzi V, Zahner E. Immunosuppressive effects of phytohemagglutinin Transplantation Proceedings. 1: 622-623. PMID 4944280 |
0.236 |
|
| 1969 |
Krenitsky TA, Neil SM, Elion GB, Hitchings GH. Adenine phosphoribosyltransferase from monkey liver. Specificity and properties. The Journal of Biological Chemistry. 244: 4779-84. PMID 4309151 |
0.614 |
|
| 1969 |
Hitchings GH, Elion GB. Role of antimetabolites in immunosuppression and transplantation Accounts of Chemical Research. 2: 202-209. DOI: 10.1021/Ar50019A002 |
0.64 |
|
| 1969 |
Krenitsky TA, Neil SM, Elion GB, Hitchings GH. Adenine Phosphoribosyltransferase from Monkey Liver Journal of Biological Chemistry. 244: 4779-4784. DOI: 10.1016/s0021-9258(18)93692-6 |
0.611 |
|
| 1969 |
Hitchings GH, Elion GB. The role of antimetabolites in immunosuppression and transplantation Accounts of Chemical Research. 2: 202-209. |
0.613 |
|
| 1968 |
Elion GB, Yü TF, Gutman AB, Hitchings GH. Renal clearance of oxipurinol, the chief metabolite of allopurinol The American Journal of Medicine. 45: 69-77. PMID 5658870 DOI: 10.1016/0002-9343(68)90008-9 |
0.658 |
|
| 1968 |
Krenitsky TA, Elion GB, Henderson AM, Hitchings GH. Inhibition of human purine nucleoside phosphorylase. Studies with intact erythrocytes and the purified enzyme. Journal of Biological Chemistry. 243: 2876-2881. PMID 5653179 |
0.641 |
|
| 1968 |
Elion GB, Benezra FM, Canellas I, Carrington LO, Hitchings GH. Effects of Xanthine Oxidase Inhibitors on Purine Catabolism Israel Journal of Chemistry. 6: 787-796. DOI: 10.1002/Ijch.196800096 |
0.684 |
|
| 1968 |
Kozma C, Salvador RA, Elion GB. Chronic allopurinol administration and iron storage in mice Life Sciences. 7: 341-348. |
0.192 |
|
| 1967 |
Krenitsky TA, Elion GB, Strelitz RA, Hitchings GH. Ribonucleosides of allopurinol and oxoallopurinol. Isolation from human urine, enzymatic synthesis, and characterization. Journal of Biological Chemistry. 242: 2675-2682. PMID 6028796 |
0.644 |
|
| 1967 |
Elion GB. Symposium on immunosuppressive drugs. Biochemistry and pharmacology of purine analogues Federation Proceedings. 26: 898-904. PMID 5337283 |
0.229 |
|
| 1967 |
Kozma C, Salvador R, Elion G. ALLOPURINOL AND IRON STORAGE The Lancet. 290: 1040-1041. DOI: 10.1016/S0140-6736(67)90310-8 |
0.168 |
|
| 1966 |
Elion GB, Kovensky A, Hitchings GH, Metz E, Rundles RW. Metabolic studies of allopurinol, an inhibitor of xanthine oxidase Biochemical Pharmacology. 15: 863-880. PMID 5967902 DOI: 10.1016/0006-2952(66)90163-8 |
0.681 |
|
| 1966 |
Elion GB. Enzymatic and metabolic studies with allopurinol Annals of the Rheumatic Diseases. 25: 608-614. PMID 5958693 |
0.239 |
|
| 1966 |
Singer S, Elion GB, Hitchings GH. Resistance to inhibitors of dihydrofolate reductase in strains of Lactobacillus casei and Proteus vulgaris. Journal of General Microbiology. 42: 185-196. PMID 5912585 |
0.626 |
|
| 1965 |
Pomales R, Elion GB, Hitchings GH. Xanthine as a precursor of nucleic acid purines in the mouse Bba Section Nucleic Acids and Protein Synthesis. 95: 505-506. PMID 14342542 |
0.657 |
|
| 1965 |
Elion GB, Hitchings GH. Metabolic basis for the actions of analogs of purines and pyrimidines. Advances in Chemotherapy. 2: 91-177. PMID 5319963 |
0.643 |
|
| 1964 |
Rundles RW, Silberman HR, Hitchings GH, Elion GB. Effects of Xanthine Oxidase Inhibitor on Clinical Manifestations and Purine Metabolism in Gout. Annals of Internal Medicine. 60: 717-718. DOI: 10.7326/0003-4819-60-4-717_2 |
0.673 |
|
| 1964 |
Trattner RB, Elion GB, Hitchings GH, Sharefkin DM. Deamination studies on pyrimidine and condensed pyrimidine systems Journal of Organic Chemistry. 29: 2674-2677. DOI: 10.1021/Jo01032A047 |
0.671 |
|
| 1963 |
ELION GB, CALLAHAN S, RUNDLES RW, HITCHINGS GH. RELATIONSHIP BETWEEN METABOLIC FATES AND ANTITUMOR ACTIVITIES OF THIOPURINES. Cancer Research. 23: 1207-1217. PMID 14070377 |
0.635 |
|
| 1963 |
HITCHINGS GH, ELION GB. Chemical suppression of the immune response. Pharmacological Reviews. 15: 365-405. PMID 13954804 |
0.611 |
|
| 1963 |
Elion GB, Callahan S, Nathan H, Bieber S, Rundles RW, Hitchings GH. Potentiation by inhibition of drug degradation : 6-substituted purines and xanthine oxidase Biochemical Pharmacology. 12: 85-93. DOI: 10.1016/0006-2952(63)90012-1 |
0.694 |
|
| 1962 |
BIEBER S, ELION GB, HITCHINGS GH, HOOPER DC, NATHAN HC. Suppression of the immune response by drugs in combination. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 111: 334-337. PMID 13968137 DOI: 10.3181/00379727-111-27783 |
0.667 |
|
| 1962 |
Elion GB. Condensed pyrimidine systems. XXII. N-methylpurines Journal of Organic Chemistry. 27: 2478-2491. |
0.231 |
|
| 1961 |
NATHAN HC, BIEBER S, ELION GB, HITCHINGS GH. Detection of agents which interfere with the immune response. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 107: 796-799. PMID 14478529 DOI: 10.3181/00379727-107-26758 |
0.655 |
|
| 1960 |
ELION GB, CALLAHAN SW, HITCHINGS GH, RUNDLES RW. The metabolism of 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio]purine (B.W. 57-323) in man. Cancer Chemotherapy Reports. Part 1. 8: 47-52. PMID 13849699 |
0.643 |
|
| 1960 |
ELION GB, BIEBER S, HITCHINGS GH. A summary of investigations with 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio]purine (B.W. 57-323) in animals. Cancer Chemotherapy Reports. Part 1. 8: 36-43. PMID 13849698 |
0.636 |
|
| 1960 |
ELION GB, SINGER S, HITCHINGS GH. Potentiation in combinations of three biochemically related antimetabolites. Antibiotica Et Chemotherapia. Fortschritte. Advances. ProgrèS. 9: 556-564. PMID 13819933 |
0.626 |
|
| 1960 |
ELION GB, BIEBER S, HITCHINGS GH. Studies on the mechanism of action of urethane on mammary adenocarcinoma 755. Acta - Unio Internationalis Contra Cancrum. 16: 605-8. PMID 13819932 |
0.614 |
|
| 1959 |
Elion GB, Mueller S, Hitchings GH. Studies on condensed pyrimidine systems. XXI. The isolation and synthesis of 6-mercapto-2,8-purinediol (6-thiouric acid) Journal of the American Chemical Society. 81: 3042-3045. DOI: 10.1021/Ja01521A033 |
0.696 |
|
| 1959 |
Elion GB, Goodman I, Lange W, Hitchings GH. Condensed pyrimidine systems. XX. Purines related to 6-mercaptopurine and thioguanine Journal of the American Chemical Society. 81: 1898-1902. DOI: 10.1021/Ja01517A030 |
0.668 |
|
| 1958 |
ELION GB, BIEBER S, NATHAN H, HITCHINGS GH. Uracil antagonism and inhibition of mammary adenocarcinoma 755. Cancer Research. 18: 802-817. PMID 13573346 |
0.635 |
|
| 1958 |
CLARKE DA, ELION GB, HITCHINGS GH, STOCK CC. Structure-activity relationships among purines related to 6-mercaptopurine. Cancer Research. 18: 445-456. PMID 13536996 |
0.622 |
|
| 1957 |
Balis ME, Levin DH, Brown GB, Elion GB, Nathan HC, Hitchings GH. The effects of 6-mercaptopurine on Lactobacillus casei Archives of Biochemistry and Biophysics. 71: 358-366. |
0.628 |
|
| 1956 |
Elion GB, Hitchings GH. Studies on condensed pyrimidine systems. XVII. Some halogenopurines Journal of the American Chemical Society. 78: 3508-3510. DOI: 10.1021/Ja01595A065 |
0.666 |
|
| 1956 |
Elion GB, Lange WH, Hitchings GH. Studies on condensed pyrimidine systems. XVI. Purines and thiazolo[5,4-d]pyrimidines from 4-amino-5-formamido-6-mercaptopyrimidines Journal of the American Chemical Society. 78: 2858-2863. DOI: 10.1021/Ja01593A062 |
0.685 |
|
| 1956 |
Elion GB, Lange WH, Hitchings GH. Studies on condensed pyrimidine systems. XIII. Some amino-substituted derivatives of guanine and 6-thioguanine Journal of the American Chemical Society. 78: 217-220. DOI: 10.1021/Ja01582A060 |
0.692 |
|
| 1955 |
HITCHINGS GH, ELION GB. The lactobacillus casei screening test. Cancer Research. 66-8. PMID 14364503 |
0.603 |
|
| 1955 |
Elion GB, Hitchings GH. The synthesis of 6-thioguanine Journal of the American Chemical Society. 77: 1676. DOI: 10.1021/Ja01611A082 |
0.672 |
|
| 1954 |
HAMILTON L, ELION GB. The fate of 6-mercaptopurine in man Annals of the New York Academy of Sciences. 60: 304-314. PMID 14350536 |
0.178 |
|
| 1954 |
ELION GB, BIEBER S, HITCHINGS GH. The fate of 6-mercaptopurine in mice. Annals of the New York Academy of Sciences. 60: 297-303. PMID 14350535 DOI: 10.1111/J.1749-6632.1954.Tb40020.X |
0.639 |
|
| 1954 |
ELION GB, SINGER S, HITCHINGS GH. Microbiological effects of 6-mercaptopurine. Annals of the New York Academy of Sciences. 60: 200-6. PMID 14350524 DOI: 10.1111/J.1749-6632.1954.Tb40009.X |
0.652 |
|
| 1954 |
HITCHINGS GH, ELION GB. The chemistry and biochemistry of purine analogs. Annals of the New York Academy of Sciences. 60: 195-9. PMID 14350523 DOI: 10.1111/J.1749-6632.1954.Tb40008.X |
0.666 |
|
| 1954 |
ELION GB, SINGER S, HITCHINGS GH. Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites. The Journal of Biological Chemistry. 208: 477-88. PMID 13174557 |
0.671 |
|
| 1954 |
SKIPPER HE, THOMSON JR, ELION GB, HITCHINGS GH. Observations on the anticancer activity of 6-mercaptopurine. Cancer Research. 14: 294-8. PMID 13160953 |
0.625 |
|
| 1954 |
Elion GB, Hitchings GH. Synthesis of 8-C14 and of S35-6-mercaptopurine Journal of the American Chemical Society. 76: 4027-4028. DOI: 10.1021/Ja01644A050 |
0.655 |
|
| 1953 |
ELION GB, SINGER S, HITCHINGS GH. The purine metabolism of a 6-mercaptopurine-resistant Lactobacillus casei. The Journal of Biological Chemistry. 204: 35-41. PMID 13084575 |
0.63 |
|
| 1953 |
CLARKE DA, PHILIPS FS, STERNBERG SS, STOCK CC, ELION GB, HITCHINGS GH. 6-Mercaptopurine: effects in mouse sarcoma 180 and in normal animals. Cancer Research. 13: 593-604. PMID 13082494 |
0.625 |
|
| 1953 |
ELION GB, SINGER S, HITCHINGS GH, BALIS ME, DROWN GB. Effects of purine antagonists on a diaminopurine-resistant strain of Lactobacillus casei. The Journal of Biological Chemistry. 202: 647-54. PMID 13061489 |
0.626 |
|
| 1953 |
ELION GB, VANDERWERFF H, HITCHINGS GH, BALIS ME, LEVIN DH, BROWN GB. Purine metabolism of a diaminopurine-resistant strain of Lactobacillus casei. The Journal of Biological Chemistry. 200: 7-16. PMID 13034753 |
0.628 |
|
| 1953 |
BALIS ME, LEVIN DH, BROWN GB, ELION GB, VANDERWERFF H, HITCHINGS GH. The utilization of purine ribotides by Lactobacillus casei. The Journal of Biological Chemistry. 200: 1-6. PMID 13034752 |
0.632 |
|
| 1953 |
Elion GB, Hitchings GH. Studies on condensed pyrimidine systems. XI. Some 8-alkyl-7-pteridones Journal of the American Chemical Society. 75: 4311-4314. DOI: 10.1021/Ja01113A050 |
0.671 |
|
| 1952 |
BALIS ME, LEVIN DH, BROWN GB, ELION GB, VANDERWERFF H, HITCHINGS GH. Utilization of some purine riboside derivatives by Lactobacillus casei. The Journal of Biological Chemistry. 199: 227-34. PMID 12999834 |
0.647 |
|
| 1952 |
HITCHINGS GH, FALCO EA, VANDERWERFF H, RUSSELL PB, ELION GB. Antagonists of nucleic acid derivatives. VII. 2, 4-Diaminopyrimidines. The Journal of Biological Chemistry. 199: 43-56. PMID 12999813 |
0.667 |
|
| 1952 |
HITCHINGS GH, FALCO EA, ELION GB, SINGER S, WARING GB, HUTCHISON DJ, BURCHENAL JH. 2, 4-Diaminopyrimidines as antagonists of folic acid and folinic acid. Archives of Biochemistry and Biophysics. 40: 479-81. PMID 12997239 DOI: 10.1016/0003-9861(52)90138-0 |
0.679 |
|
| 1952 |
BALIS ME, LEVIN DH, BROWN GB, ELION GB, VANDERWERFF H, HITCHINGS GH. The incorporation of exogenous purines into pentose nucleic acid by Lactobacillus casei. The Journal of Biological Chemistry. 196: 729-47. PMID 12981013 |
0.658 |
|
| 1952 |
Falco EA, Elion GB, Burgi E, Hitchings GH. Studies on condensed pyrimidine systems. X. Some 1,3-oxazolo(5,4-d)pyrimidines Journal of the American Chemical Society. 74: 4897-4902. DOI: 10.1021/Ja01139A049 |
0.665 |
|
| 1952 |
Elion GB, Hitchings GH. The identification of "β-dihydroxanthopterin" as 2,4-diamino-6-hydroxy-p-oxazino (2,3-d)pyrimidine Journal of the American Chemical Society. 74: 3877-3882. DOI: 10.1021/Ja01135A048 |
0.649 |
|
| 1952 |
Elion GB, Burgi E, Hitchings GH. Studies on condensed pyrimidine systems. IX. The synthesis of some 6-substituted purines Journal of the American Chemical Society. 74: 411-414. DOI: 10.1021/Ja01122A037 |
0.688 |
|
| 1951 |
ELION GB, HITCHINGS GH, VANDERWERFF H. Antagonists of nucleic acid derivatives. VI. Purines. The Journal of Biological Chemistry. 192: 505-18. PMID 14907641 |
0.667 |
|
| 1951 |
ELION GB, HITCHINGS GH. Antagonists of nucleic acid derivatives. V. Pteridines. The Journal of Biological Chemistry. 188: 611-21. PMID 14824148 |
0.657 |
|
| 1951 |
BALIS ME, BROWN GB, ELION GB, HITCHINGS GH, VANDERWERFF H. On the interconversion of purines by Lactobacillus casei. The Journal of Biological Chemistry. 188: 217-9. PMID 14814131 |
0.642 |
|
| 1951 |
BIESELE JJ, BERGER RE, WILSON AY, HITCHINGS GH, ELION GB. Studies on 2,6-diaminopurine and related substances in cultures of embryonic and sarcomatous rodent tissues. Cancer. 4: 186-97. PMID 14801789 DOI: 10.1002/1097-0142(195101)4:1<186::Aid-Cncr2820040123>3.0.Co;2-# |
0.641 |
|
| 1951 |
Elion GB, Burgi E, Hitchings GH. Studies on condensed pyrimidine systems. VII. Some 8-arylpurines Journal of the American Chemical Society. 73: 5235-5239. DOI: 10.1021/Ja01155A070 |
0.666 |
|
| 1950 |
HITCHINGS GH, ELION GB, FALCO EA, RUSSELL PB, VANDERWERFF H. Studies on analogs of purines and pyrimidines. Annals of the New York Academy of Sciences. 52: 1318-35. PMID 15433149 DOI: 10.1111/J.1749-6632.1950.Tb54032.X |
0.681 |
|
| 1950 |
ELION GB, HITCHINGS GH. Antagonists of nucleic acid derivatives. IV. Reversal studies with 2-aminopurine and 2,6-diaminopurine. The Journal of Biological Chemistry. 187: 511-22. PMID 14803432 |
0.669 |
|
| 1950 |
THOMPSON RL, PRICE ML, MINTON SA, ELION GB, HITCHINGS GH. Effects of purine derivatives and analogues on multiplication of the vaccinia virus. Journal of Immunology (Baltimore, Md. : 1950). 65: 529-34. PMID 14794918 |
0.643 |
|
| 1950 |
HITCHINGS GH, ELION GB, FALCO EA. Antagonists of nucleic acid derivatives. II. Reversal studies with substances structurally related to thymine. The Journal of Biological Chemistry. 185: 643-9. PMID 14774407 |
0.652 |
|
| 1950 |
Elion GB, Hitchings GH, Russell PB. The formation of 6-hydroxy- and 7-hydroxypteridines from 4,5-diaminopyrimidines and α-ketoacids and esters Journal of the American Chemical Society. 72: 78-81. DOI: 10.1021/Ja01157A022 |
0.647 |
|
| 1950 |
Elion GB, Hitchings GH. ANTAGONISTS OF NUCLEIC ACID DERIVATIVES Journal of Biological Chemistry. 187: 511-522. DOI: 10.1016/s0021-9258(18)56194-9 |
0.666 |
|
| 1949 |
Elion GB, Light AE, Hitchings GH. The preparation of xanthopterin Journal of the American Chemical Society. 71: 741. PMID 18112077 DOI: 10.1021/Ja01170A504 |
0.651 |
|
| 1949 |
HITCHINGS GH, ELION GB. Isomeric dihydroxanthopterins. Journal of the American Chemical Society. 71: 467-73. PMID 18112059 |
0.616 |
|
| 1949 |
HITCHINGS GH, ELION GB. A new synthesis of cytosine and 5-methylcytosine. The Journal of Biological Chemistry. 177: 357-60. PMID 18107440 |
0.641 |
|
| 1949 |
Thompson RL, Wilkin ML, Hitchings GH, Elion GB, Falco EA, Russell PB. The Effects of Antagonists on the Multiplication of Vaccinia Virus in Vitro. Science (New York, N.Y.). 110: 454. PMID 17787837 DOI: 10.1126/Science.110.2861.454 |
0.662 |
|
| 1949 |
Elion GB, Light AE, Hitchings GH. Additions and Corrections-The Preparation of Xanthopterin Journal of the American Chemical Society. 71: 4165-4165. DOI: 10.1021/Ja01180A618 |
0.653 |
|
| 1949 |
Hitchings GH, Elion GB. Additions and Corrections-Isometric Dihydroxanthopterins Journal of the American Chemical Society. 71: 4165-4165. DOI: 10.1021/Ja01180A617 |
0.641 |
|
| 1949 |
Russell PB, Elion GB, Falco EA, Hitchings GH. A synthesis of 4-amino-2-thiolpyrimidines Journal of the American Chemical Society. 71: 2279-2282. DOI: 10.1021/Ja01175A001 |
0.687 |
|
| 1949 |
Russell PB, Elion GB, Hitchings GH. A new condensed pyrimidine system: Some p-oxazino[2,3-d]pyrimidines Journal of the American Chemical Society. 71: 474-478. DOI: 10.1021/Ja01170A029 |
0.655 |
|
| 1948 |
HITCHINGS GH, ELION GB, VANDERWERFF H. The limitations of inhibition analysis. The Journal of Biological Chemistry. 174: 1037. PMID 18871261 |
0.631 |
|
| 1948 |
HITCHINGS GH, ELION GB. Pyrimidine derivatives as antagonists of pteroylglutamic acid. The Journal of Biological Chemistry. 174: 765. PMID 18865647 |
0.67 |
|
| 1947 |
ELION GB, HITCHINGS GH. The direct thiation of uracils. Journal of the American Chemical Society. 69: 2138. PMID 20262741 DOI: 10.1021/Ja01201A025 |
0.645 |
|
| 1947 |
Elion GB, Hitchings GH. The synthesis of some new pteridines Journal of the American Chemical Society. 69: 2553-2555. DOI: 10.1021/Ja01202A502 |
0.664 |
|
| 1946 |
Elion GB, Ide WS, Hitchings GH. The Ultraviolet Absorption Spectra of Thiouracils1 Journal of the American Chemical Society. 68: 2137-2140. PMID 21002213 DOI: 10.1021/Ja01215A004 |
0.632 |
|
| 1943 |
Galat A, Elion G. The Interaction of Amides with Amines: A General Method of Acylation1 Journal of the American Chemical Society. 65: 1566-1567. DOI: 10.1021/Ja01248A033 |
0.314 |
|
| 1939 |
Galat A, Elion G. The Preparation of Primary Amines Journal of the American Chemical Society. 61: 3585-3586. DOI: 10.1021/Ja01267A504 |
0.333 |
|
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