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Evette S. Radisky, Ph.D. - Publications

1995-2000 Chemistry University of Utah, Salt Lake City, UT 

46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Cohen I, Kayode O, Hockla A, Sankaran B, Radisky DC, Radisky ES, Papo N. Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy. The Biochemical Journal. PMID 26957636 DOI: 10.1042/Bj20151410  1
2015 Mehner C, Oberg AL, Kalli KR, Nassar A, Hockla A, Pendlebury D, Cichon MA, Goergen KM, Maurer MJ, Goode EL, Keeney GL, Jatoi A, Sahin-Tóth M, Copland JA, Radisky DC, ... Radisky ES, et al. Serine protease inhibitor Kazal type 1 (SPINK1) drives proliferation and anoikis resistance in a subset of ovarian cancers. Oncotarget. 6: 35737-35754. PMID 26437224 DOI: 10.18632/Oncotarget.5927  1
2015 Alloy AP, Kayode O, Wang R, Hockla A, Soares AS, Radisky ES. Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates. The Journal of Biological Chemistry. PMID 26175157 DOI: 10.1074/Jbc.M115.662429  1
2015 Radisky ES, Radisky DC. Matrix metalloproteinases as breast cancer drivers and therapeutic targets. Frontiers in Bioscience (Landmark Edition). 20: 1144-63. PMID 25961550 DOI: 10.2741/4364  1
2014 Pendlebury D, Wang R, Henin RD, Hockla A, Soares AS, Madden BJ, Kazanov MD, Radisky ES. Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin. The Journal of Biological Chemistry. 289: 32783-97. PMID 25301953 DOI: 10.1074/Jbc.M114.609560  1
2014 Szabó A, Salameh MA, Ludwig M, Radisky ES, Sahin-Tóth M. Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids. Plos One. 9: e102063. PMID 25010489 DOI: 10.1371/Journal.Pone.0102063  1
2014 Mehner C, Miller E, Khauv D, Nassar A, Oberg AL, Bamlet WR, Zhang L, Waldmann J, Radisky ES, Crawford HC, Radisky DC. Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma. Molecular Cancer Research : McR. 12: 1430-9. PMID 24850902 DOI: 10.1158/1541-7786.Mcr-13-0557-T  1
2014 Mehner C, Hockla A, Miller E, Ran S, Radisky DC, Radisky ES. Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer. Oncotarget. 5: 2736-49. PMID 24811362 DOI: 10.18632/Oncotarget.1932  1
2014 Szabó A, Radisky ES, Sahin-Tóth M. Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation. The Journal of Biological Chemistry. 289: 4753-61. PMID 24403079 DOI: 10.1074/Jbc.M113.538884  1
2013 Batra J, Soares AS, Mehner C, Radisky ES. Matrix metalloproteinase-10/TIMP-2 structure and analyses define conserved core interactions and diverse exosite interactions in MMP/TIMP complexes. Plos One. 8: e75836. PMID 24073280 DOI: 10.1371/Journal.Pone.0075836  1
2013 Salameh MA, Radisky ES. Biochemical and structural insights into mesotrypsin: an unusual human trypsin. International Journal of Biochemistry and Molecular Biology. 4: 129-39. PMID 24049668  1
2013 Chen F, Radisky ES, Das P, Batra J, Hata T, Hori T, Baine AM, Gardner L, Yue MY, Bu G, del Zoppo G, Patel TC, Nguyen JH. TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 1041-9. PMID 23532086 DOI: 10.1038/Jcbfm.2013.45  1
2013 Radisky ES. PRSS3/mesotrypsin in prostate cancer progression: implications for translational medicine. Asian Journal of Andrology. 15: 439-40. PMID 23503422 DOI: 10.1038/Aja.2013.14  1
2013 Batra J, Szabó A, Caulfield TR, Soares AS, Sahin-Tóth M, Radisky ES. Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation. The Journal of Biological Chemistry. 288: 9848-59. PMID 23430245 DOI: 10.1074/Jbc.M113.457382  1
2013 Chen JM, Radisky ES, Férec C. Human Trypsins Handbook of Proteolytic Enzymes. 3: 2600-2609. DOI: 10.1016/B978-0-12-382219-2.00576-7  1
2012 Hockla A, Miller E, Salameh MA, Copland JA, Radisky DC, Radisky ES. PRSS3/mesotrypsin is a therapeutic target for metastatic prostate cancer. Molecular Cancer Research : McR. 10: 1555-66. PMID 23258495 DOI: 10.1158/1541-7786.Mcr-12-0314  1
2012 Batra J, Robinson J, Mehner C, Hockla A, Miller E, Radisky DC, Radisky ES. PEGylation extends circulation half-life while preserving in vitro and in vivo activity of tissue inhibitor of metalloproteinases-1 (TIMP-1). Plos One. 7: e50028. PMID 23185522 DOI: 10.1371/Journal.Pone.0050028  1
2012 Stallings-Mann ML, Waldmann J, Zhang Y, Miller E, Gauthier ML, Visscher DW, Downey GP, Radisky ES, Fields AP, Radisky DC. Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression. Science Translational Medicine. 4: 142ra95. PMID 22786680 DOI: 10.1126/Scitranslmed.3004062  1
2012 Salameh MA, Soares AS, Alloy A, Radisky ES. Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors. Protein Science : a Publication of the Protein Society. 21: 1103-12. PMID 22610453 DOI: 10.1002/Pro.2097  1
2012 Liu H, Radisky DC, Yang D, Xu R, Radisky ES, Bissell MJ, Bishop JM. MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits. Nature Cell Biology. 14: 567-74. PMID 22581054 DOI: 10.1038/Ncb2491  1
2012 Justilien V, Regala RP, Tseng IC, Walsh MP, Batra J, Radisky ES, Murray NR, Fields AP. Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential. Plos One. 7: e35040. PMID 22545096 DOI: 10.1371/Journal.Pone.0035040  1
2012 Batra J, Robinson J, Soares AS, Fields AP, Radisky DC, Radisky ES. Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure. The Journal of Biological Chemistry. 287: 15935-46. PMID 22427646 DOI: 10.1074/Jbc.M112.341156  1
2011 Salameh MA, Soares AS, Hockla A, Radisky DC, Radisky ES. The P(2)' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity. The Biochemical Journal. 440: 95-105. PMID 21806544 DOI: 10.1042/Bj20110788  1
2011 Cichon MA, Radisky ES, Radisky DC. Identifying the stroma as a critical player in radiation-induced mammary tumor development. Cancer Cell. 19: 571-2. PMID 21575857 DOI: 10.1016/J.Ccr.2011.05.001  1
2011 Szabó A, Héja D, Szakács D, Zboray K, Kékesi KA, Radisky ES, Sahin-Tóth M, Pál G. High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues. The Journal of Biological Chemistry. 286: 22535-45. PMID 21515688 DOI: 10.1074/Jbc.M111.235754  1
2010 Salameh MA, Soares AS, Navaneetham D, Sinha D, Walsh PN, Radisky ES. Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin. The Journal of Biological Chemistry. 285: 36884-96. PMID 20861008 DOI: 10.1074/Jbc.M110.171348  1
2010 Radisky ES. Cathepsin D: Regulation in mammary gland remodeling, misregulation in breast cancer. Cancer Biology & Therapy. 10: 467-70. PMID 20647745 DOI: 10.4161/Cbt.10.5.12855  1
2010 Radisky ES, Radisky DC. Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer. Journal of Mammary Gland Biology and Neoplasia. 15: 201-12. PMID 20440544 DOI: 10.1007/S10911-010-9177-X  1
2010 Orlichenko L, Geyer R, Yanagisawa M, Khauv D, Radisky ES, Anastasiadis PZ, Radisky DC. The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin. The Journal of Biological Chemistry. 285: 19153-61. PMID 20395297 DOI: 10.1074/Jbc.M109.099382  1
2010 Hockla A, Radisky DC, Radisky ES. Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109. Breast Cancer Research and Treatment. 124: 27-38. PMID 20035377 DOI: 10.1007/S10549-009-0699-0  1
2010 Salameh MA, Robinson JL, Navaneetham D, Sinha D, Madden BJ, Walsh PN, Radisky ES. The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin. The Journal of Biological Chemistry. 285: 1939-49. PMID 19920152 DOI: 10.1074/Jbc.M109.057216  1
2009 Chen CS, Nelson CM, Khauv D, Bennett S, Radisky ES, Hirai Y, Bissell MJ, Radisky DC. Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis. The Journal of Biological Chemistry. 284: 6877-84. PMID 19129200 DOI: 10.1074/Jbc.M805908200  1
2008 Salameh MA, Soares AS, Hockla A, Radisky ES. Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsin. The Journal of Biological Chemistry. 283: 4115-23. PMID 18077447 DOI: 10.1074/Jbc.M708268200  1
2007 Radisky ES, Radisky DC. Stromal induction of breast cancer: inflammation and invasion. Reviews in Endocrine & Metabolic Disorders. 8: 279-87. PMID 17447144 DOI: 10.1007/S11154-007-9037-1  1
2006 Radisky ES, Lee JM, Lu CJ, Koshland DE. Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates. Proceedings of the National Academy of Sciences of the United States of America. 103: 6835-40. PMID 16636277 DOI: 10.1073/Pnas.0601910103  1
2005 Radisky ES, Lu CJ, Kwan G, Koshland DE. Role of the intramolecular hydrogen bond network in the inhibitory power of chymotrypsin inhibitor 2. Biochemistry. 44: 6823-30. PMID 15865427 DOI: 10.1021/Bi047301W  1
2004 Radisky ES, Kwan G, Karen Lu CJ, Koshland DE. Binding, proteolytic, and crystallographic analyses of mutations at the protease-inhibitor interface of the subtilisin BPN'/chymotrypsin inhibitor 2 complex. Biochemistry. 43: 13648-56. PMID 15504027 DOI: 10.1021/Bi048797K  1
2003 Radisky ES, King DS, Kwan G, Koshland DE. The role of the protein core in the inhibitory power of the classic serine protease inhibitor, chymotrypsin inhibitor 2. Biochemistry. 42: 6484-92. PMID 12767231 DOI: 10.1021/Bi034275D  1
2002 Radisky ES, Koshland DE. A clogged gutter mechanism for protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 99: 10316-21. PMID 12142461 DOI: 10.1073/Pnas.112332899  1
2000 Radisky ES, Poulter CD. Squalene synthase: steady-state, pre-steady-state, and isotope-trapping studies. Biochemistry. 39: 1748-60. PMID 10677224 DOI: 10.1021/Bi9915014  1
1999 Wu Z, Demma M, Strickland CL, Radisky ES, Poulter CD, Le HV, Windsor WT. Farnesyl protein transferase: identification of K164 alpha and Y300 beta as catalytic residues by mutagenesis and kinetic studies. Biochemistry. 38: 11239-49. PMID 10471273 DOI: 10.1021/Bi990583T  1
1997 Ajioka RS, Jorde LB, Gruen JR, Yu P, Dimitrova D, Barrow J, Radisky E, Edwards CQ, Griffen LM, Kushner JP. Haplotype analysis of hemochromatosis: Evaluation of different linkage- disequilibrium approaches and evolution of disease chromosomes American Journal of Human Genetics. 60: 1439-1447. PMID 9199565 DOI: 10.1086/515466  1
1994 Radisky ES, Ajioka RS, Edwards CQ, Griffen LM, Kushner JP. Mapping recombinant events with molecular markers in hemochromatosis pedigrees. Cytogenetics and Cell Genetics. 67: 126-8. PMID 7913677 DOI: 10.1159/000133812  1
1993 Radisky DC, Radisky ES, Barrows LR, Copp BR, Kramer RA, Ireland CM. Novel cytotoxic topoisomerase II inhibiting pyrroloiminoquinones from Fijian sponges of the genus Zyzzya Journal of the American Chemical Society. 115: 1632-1638. DOI: 10.1021/Ja00058A003  1
1992 Yu Y, Radisky E, Leibold EA. The iron-responsive element binding protein: Purification, cloning, and regulation in rat liver Journal of Biological Chemistry. 267: 19005-19010. PMID 1527027  1
1990 Garey JR, Harrison LM, Franklin KF, Metcalf KM, Radisky ES, Kushner JP. Uroporphyrinogen decarboxylase: a splice site mutation causes the deletion of exon 6 in multiple families with porphyria cutanea tarda. The Journal of Clinical Investigation. 86: 1416-22. PMID 2243121 DOI: 10.1172/Jci114856  1
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