Melanie I. Stefan, PhD

2015- Centre for Integrative Physiology University of Edinburgh, Edinburgh, Scotland, United Kingdom 
Synaptic signalling; Calcium signalling; multi-state modelling
"Melanie Stefan"

I am a Lecturer at the School of Biomedical Sciences at the University of Edinburgh (UK). My research interests revolve around using computers to understand learning and memory, from simulating how proteins in the brain work together to strengthen the connection between neurons to using educational data to understand how students learn. My teaching appointment is within the Dual Award Honours degree program at the University of Edinburgh (UK) and Zhejiang University (China).

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Christiane Nüsslein-Volhard research assistant 2004-2004 Max Planck Institute for Developmental Biology (Neurotree)
Nicolas Le Novère grad student 2005-2010 EMBL-European Bioinformatics Institute
Shinya Kuroda post-doc 2010-2010 University of Tokyo (Neurotree)
Mary B. Kennedy post-doc 2010-2013 Caltech (Neurotree)
Johanna Lee Gutlerner post-doc 2013-2014 Harvard Medical School (Neurotree)
 (Curriculum fellow)
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Pharris MC, Patel NM, VanDyk TG, et al. (2019) A Multi-State Model of the CaMKII Dodecamer Suggests a Role for Calmodulin in Maintenance of Autophosphorylation. Plos Computational Biology. 15: e1006941
Viswan NA, HarshaRani GV, Stefan MI, et al. (2018) FindSim: A Framework for Integrating Neuronal Data and Signaling Models. Frontiers in Neuroinformatics. 12: 38
Roy RD, Rosenmund C, Stefan MI. (2017) Cooperative binding mitigates the high-dose hook effect. Bmc Systems Biology. 11: 74
Rodriguez N, Pettit JB, Dalle Pezze P, et al. (2016) The systems biology format converter. Bmc Bioinformatics. 17: 154
Stefan MI, Gutlerner JL, Born RT, et al. (2015) The quantitative methods boot camp: teaching quantitative thinking and computing skills to graduate students in the life sciences. Plos Computational Biology. 11: e1004208
Stefan MI, Bartol TM, Sejnowski TJ, et al. (2014) Multi-state modeling of biomolecules. Plos Computational Biology. 10: e1003844
Dutta Roy R, Stefan MI, Rosenmund C. (2014) Biophysical properties of presynaptic short-term plasticity in hippocampal neurons: insights from electrophysiology, imaging and mechanistic models. Frontiers in Cellular Neuroscience. 8: 141
Stefan MI, Le Novère N. (2013) Cooperative binding. Plos Computational Biology. 9: e1003106
Li L, Stefan MI, Le Novère N. (2012) Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII. Plos One. 7: e43810
Stefan MI, Marshall DP, Le Novère N. (2012) Structural analysis and stochastic modelling suggest a mechanism for calmodulin trapping by CaMKII. Plos One. 7: e29406
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