Jason I. Herschkowitz, Ph.D. - Publications

Affiliations: 
2008 Genetics & Molecular Biology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Bioinformatics, Genetics, Oncology

34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Bai F, Wang C, Liu X, Hollern D, Liu S, Fan C, Liu C, Ren S, Herschkowitz JI, Zhu WG, Pei XH. Loss of function of BRCA1 promotes EMT in mammary tumors through activation of TGFβR2 signaling pathway. Cell Death & Disease. 13: 195. PMID 35236825 DOI: 10.1038/s41419-022-04646-7  0.563
2021 Ropri AS, DeVaux RS, Eng J, Chittur SV, Herschkowitz JI. Cis-acting super-enhancer lncRNAs as biomarkers to early-stage breast cancer. Breast Cancer Research : Bcr. 23: 101. PMID 34717732 DOI: 10.1186/s13058-021-01479-8  0.358
2020 DeVaux RS, Ropri AS, Grimm SL, Hall PA, Herrera EO, Chittur SV, Smith WP, Coarfa C, Behbod F, Herschkowitz JI. Long noncoding RNA BHLHE40-AS1 promotes early breast cancer progression through modulating IL-6/STAT3 signaling. Journal of Cellular Biochemistry. PMID 31907974 DOI: 10.1002/Jcb.29621  0.336
2018 DeVaux RS, Herschkowitz JI. Beyond DNA: the Role of Epigenetics in the Premalignant Progression of Breast Cancer. Journal of Mammary Gland Biology and Neoplasia. PMID 30306389 DOI: 10.1007/s10911-018-9414-2  0.353
2016 Ramirez L, Herschkowitz JI, Wang J. Stand-Sit Microchip for High-Throughput, Multiplexed Analysis of Single Cancer Cells. Scientific Reports. 6: 32505. PMID 27581736 DOI: 10.1038/srep32505  0.351
2016 Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, et al. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nature Cell Biology. PMID 27183469 DOI: 10.1038/Ncb3355  0.304
2016 Pfefferle AD, Agrawal YN, Koboldt DC, Kanchi KL, Herschkowitz JI, Mardis ER, Rosen JM, Perou CM. Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53 deficient mammary cancers. Disease Models & Mechanisms. PMID 27149990 DOI: 10.1242/Dmm.025239  0.661
2015 Elsarraj HS, Hong Y, Valdez KE, Michaels W, Hook M, Smith WP, Chien J, Herschkowitz JI, Troester MA, Beck M, Inciardi M, Gatewood J, May L, Cusick T, McGinness M, et al. Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. Breast Cancer Research : Bcr. 17: 128. PMID 26384318 DOI: 10.1186/S13058-015-0630-Z  0.46
2015 Pei X, Bai F, Chan HL, Scott A, Smith MD, Fan C, Herschkowitz JI, Perou CM, Livingstone AS, Robbins DJ, Capobianco AJ. Abstract P4-05-01: Genetic analysis of the role of Brca1 in suppression of basal-like breast cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P4-05-01  0.706
2014 Bai F, Chan HL, Scott A, Smith MD, Fan C, Herschkowitz JI, Perou CM, Livingstone AS, Robbins DJ, Capobianco AJ, Pei XH. BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development. Cancer Research. 74: 6161-72. PMID 25239453 DOI: 10.1158/0008-5472.Can-14-1119  0.704
2014 Sandhu R, Rein J, D'Arcy M, Herschkowitz JI, Hoadley KA, Troester MA. Overexpression of miR-146a in basal-like breast cancer cells confers enhanced tumorigenic potential in association with altered p53 status. Carcinogenesis. 35: 2567-75. PMID 25123132 DOI: 10.1093/Carcin/Bgu175  0.571
2014 Nair R, Roden DL, Teo WS, McFarland A, Junankar S, Ye S, Nguyen A, Yang J, Nikolic I, Hui M, Morey A, Shah J, Pfefferle AD, Usary J, Selinger C, ... ... Herschkowitz JI, et al. c-Myc and Her2 cooperate to drive a stem-like phenotype with poor prognosis in breast cancer. Oncogene. 33: 3992-4002. PMID 24056965 DOI: 10.1038/Onc.2013.368  0.582
2013 Pfefferle AD, Herschkowitz JI, Usary J, Harrell JC, Spike BT, Adams JR, Torres-Arzayus MI, Brown M, Egan SE, Wahl GM, Rosen JM, Perou CM. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biology. 14: R125. PMID 24220145 DOI: 10.1186/Gb-2013-14-11-R125  0.624
2013 Usary J, Zhao W, Darr D, Roberts PJ, Liu M, Balletta L, Karginova O, Jordan J, Combest A, Bridges A, Prat A, Cheang MC, Herschkowitz JI, Rosen JM, Zamboni W, et al. Predicting drug responsiveness in human cancers using genetically engineered mice. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 4889-99. PMID 23780888 DOI: 10.1158/1078-0432.Ccr-13-0522  0.598
2013 Knight JF, Lesurf R, Zhao H, Pinnaduwage D, Davis RR, Saleh SM, Zuo D, Naujokas MA, Chughtai N, Herschkowitz JI, Prat A, Mulligan AM, Muller WJ, Cardiff RD, Gregg JP, et al. Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 110: E1301-10. PMID 23509284 DOI: 10.1073/Pnas.1210353110  0.623
2013 Hollier BG, Tinnirello AA, Werden SJ, Evans KW, Taube JH, Sarkar TR, Sphyris N, Shariati M, Kumar SV, Battula VL, Herschkowitz JI, Guerra R, Chang JT, Miura N, Rosen JM, et al. FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer. Cancer Research. 73: 1981-92. PMID 23378344 DOI: 10.1158/0008-5472.Can-12-2962  0.558
2012 Herschkowitz JI, Zhao W, Zhang M, Usary J, Murrow G, Edwards D, Knezevic J, Greene SB, Darr D, Troester MA, Hilsenbeck SG, Medina D, Perou CM, Rosen JM. Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 2778-83. PMID 21633010 DOI: 10.1073/Pnas.1018862108  0.677
2011 Jiang Z, Jones R, Liu JC, Deng T, Robinson T, Chung PE, Wang S, Herschkowitz JI, Egan SE, Perou CM, Zacksenhaus E. RB1 and p53 at the crossroad of EMT and triple-negative breast cancer. Cell Cycle (Georgetown, Tex.). 10: 1563-70. PMID 21502814 DOI: 10.4161/Cc.10.10.15703  0.7
2011 Giulianelli S, Herschkowitz JI, Patel V, Lamb CA, Gutkind JS, Molinolo A, Perou CM, Lanari C. MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements. Breast Cancer Research and Treatment. 129: 49-67. PMID 20890655 DOI: 10.1007/S10549-010-1185-4  0.6
2010 Herschkowitz JI, Lubet R. Mouse models of triple negative [basal-like/claudin low] breast cancer. Breast Disease. 32: 63-71. PMID 21965308 DOI: 10.3233/BD-2010-0321  0.432
2010 Prat A, Parker JS, Karginova O, Fan C, Livasy C, Herschkowitz JI, He X, Perou CM. Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Research : Bcr. 12: R68. PMID 20813035 DOI: 10.1186/Bcr2635  0.737
2010 Taube JH, Herschkowitz JI, Komurov K, Zhou AY, Gupta S, Yang J, Hartwell K, Onder TT, Gupta PB, Evans KW, Hollier BG, Ram PT, Lander ES, Rosen JM, Weinberg RA, et al. Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proceedings of the National Academy of Sciences of the United States of America. 107: 15449-54. PMID 20713713 DOI: 10.1073/Pnas.1004900107  0.4
2010 Jiang Z, Deng T, Jones R, Li H, Herschkowitz JI, Liu JC, Weigman VJ, Tsao MS, Lane TF, Perou CM, Zacksenhaus E. Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status. The Journal of Clinical Investigation. 120: 3296-309. PMID 20679727 DOI: 10.1172/Jci41490  0.701
2010 Pond AC, Herschkowitz JI, Schwertfeger KL, Welm B, Zhang Y, York B, Cardiff RD, Hilsenbeck S, Perou CM, Creighton CJ, Lloyd RE, Rosen JM. Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer. Cancer Research. 70: 4868-79. PMID 20501844 DOI: 10.1158/0008-5472.Can-09-4404  0.56
2010 Herschkowitz JI. Breast cancer stem cells: initiating a new sort of thinking. Disease Models & Mechanisms. 3: 257-8. PMID 20427552 DOI: 10.1242/dmm.005207  0.393
2009 Creighton CJ, Li X, Landis M, Dixon JM, Neumeister VM, Sjolund A, Rimm DL, Wong H, Rodriguez A, Herschkowitz JI, Fan C, Zhang X, He X, Pavlick A, Gutierrez MC, et al. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proceedings of the National Academy of Sciences of the United States of America. 106: 13820-5. PMID 19666588 DOI: 10.1073/Pnas.0905718106  0.591
2009 Troester MA, Herschkowitz JI, Hoadley KA. Molecular signatures of drug resistance Drug Resistance in Cancer Cells. 271-294. DOI: 10.1007/978-0-387-89445-4_12  0.473
2008 Herschkowitz JI, He X, Fan C, Perou CM. The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas. Breast Cancer Research : Bcr. 10: R75. PMID 18782450 DOI: 10.1186/Bcr2142  0.571
2008 Wright MH, Robles AI, Herschkowitz JI, Hollingshead MG, Anver MR, Perou CM, Varticovski L. Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1. Molecular Cancer. 7: 29. PMID 18394172 DOI: 10.1186/1476-4598-7-29  0.661
2008 Bultman SJ, Herschkowitz JI, Godfrey V, Gebuhr TC, Yaniv M, Perou CM, Magnuson T. Characterization of mammary tumors from Brg1 heterozygous mice Oncogene. 27: 460-468. PMID 17637742 DOI: 10.1038/Sj.Onc.1210664  0.663
2007 Li Z, Tognon CE, Godinho FJ, Yasaitis L, Hock H, Herschkowitz JI, Lannon CL, Cho E, Kim SJ, Bronson RT, Perou CM, Sorensen PH, Orkin SH. ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. Cancer Cell. 12: 542-58. PMID 18068631 DOI: 10.1016/J.Ccr.2007.11.012  0.625
2007 Burkart MF, Wren JD, Herschkowitz JI, Perou CM, Garner HR. Clustering microarray-derived gene lists through implicit literature relationships. Bioinformatics (Oxford, England). 23: 1995-2003. PMID 17537751 DOI: 10.1093/Bioinformatics/Btm261  0.508
2007 Herschkowitz JI, Simin K, Weigman VJ, Mikaelian I, Usary J, Hu Z, Rasmussen KE, Jones LP, Assefnia S, Chandrasekharan S, Backlund MG, Yin Y, Khramtsov AI, Bastein R, Quackenbush J, et al. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biology. 8: R76. PMID 17493263 DOI: 10.1186/Gb-2007-8-5-R76  0.69
2006 Troester MA, Herschkowitz JI, Oh DS, He X, Hoadley KA, Barbier CS, Perou CM. Gene expression patterns associated with p53 status in breast cancer. Bmc Cancer. 6: 276. PMID 17150101 DOI: 10.1186/1471-2407-6-276  0.714
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