Kimberly D. Siegmund - Publications

Preventive Medicine University of Southern California, Los Angeles, CA, United States 

104 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Habeshian TS, Cannavale KL, Slezak JM, Shu YH, Chien GW, Chen X, Shi F, Siegmund KD, Van Den Eeden SK, Huang J, Chao CR. DNA methylation markers for risk of metastasis in a cohort of men with localized prostate cancer. Epigenetics. 19: 2308920. PMID 38525786 DOI: 10.1080/15592294.2024.2308920  0.305
2020 Miles FL, Mashchak A, Filippov V, Orlich MJ, Duerksen-Hughes P, Chen X, Wang C, Siegmund K, Fraser GE. DNA Methylation Profiles of Vegans and Non-Vegetarians in the Adventist Health Study-2 Cohort. Nutrients. 12. PMID 33266012 DOI: 10.3390/nu12123697  0.317
2020 Xu T, Li HT, Wei J, Li M, Hsieh TC, Lu YT, Lakshminarasimhan R, Xu R, Hodara E, Morrison G, Gujar H, Rhie SK, Siegmund K, Liang G, Goldkorn A. Epigenetic plasticity potentiates a rapid cyclical shift to and from an aggressive cancer phenotype. International Journal of Cancer. PMID 32017074 DOI: 10.1002/Ijc.32904  0.393
2020 Park SL, Patel Y, Loo LWM, Lum-Jones A, Tiirikainen M, Murphy S, Siegmund K, Stram DO, Marchand LL. Abstract C047: Internal smoking dose is associated with specific blood DNA methylation patterns across race/ethnicity: The Multiethnic Cohort Study Cancer Epidemiology, Biomarkers & Prevention. DOI: 10.1158/1538-7755.Disp19-C047  0.341
2019 Pandey P, Yang Z, Shibata D, Marjoram P, Siegmund KD. Mutational signatures in colon cancer. Bmc Research Notes. 12: 788. PMID 31796096 DOI: 10.1186/S13104-019-4820-0  0.343
2019 Yang Z, Pandey P, Shibata D, Conti DV, Marjoram P, Siegmund KD. HiLDA: a statistical approach to investigate differences in mutational signatures. Peerj. 7: e7557. PMID 31523512 DOI: 10.7717/Peerj.7557  0.322
2019 Wang J, Van Den Berg D, Hwang AE, Weisenberger D, Triche T, Nathwani BN, Conti DV, Siegmund K, Mack TM, Horvath S, Cozen W. DNA methylation patterns of adult survivors of adolescent/young adult Hodgkin lymphoma compared to their unaffected monozygotic twin. Leukemia & Lymphoma. 1-9. PMID 30668190 DOI: 10.1080/10428194.2018.1533128  0.471
2019 OSKOUI HB, BOGUMIL DD, KYSH L, BARRETT M, SIEGMUND K, CORTESSIS VK. 1685-P: Type 1 Diabetes Mellitus and Incident Bladder Cancer: A Systematic Review and Meta-analysis Diabetes. 68: 1685-P. DOI: 10.2337/Db19-1685-P  0.319
2019 Lu Y, Gooden GC, Tew BY, Buckley D, Siegmund K, Daneshmand S, Salhia B, Goldkorn A. Cell-free DNA (cfDNA) whole genome bisulfite sequencing in patients with muscle-invasive bladder cancer patient treated with cystectomy with curative intent. Journal of Clinical Oncology. 37: 359-359. DOI: 10.1200/Jco.2019.37.7_Suppl.359  0.411
2019 Lu Y, Gooden GC, Tew BY, Buckley D, Siegmund K, Daneshmand S, Salhia B, Goldkorn A. Epigenomic profiling of plasma cell-free DNA (cfDNA) to predict bladder cancer recurrence after radical cystectomy. Journal of Clinical Oncology. 37: e14525-e14525. DOI: 10.1200/Jco.2019.37.15_Suppl.E14525  0.406
2019 Wiemels JL, Muskens IS, Li S, Pandey P, Roy R, Hansen HM, Siegmund KD, Mueller BA, Ma X, Metayer C, Smith AJd. The Genome-Wide Impact of Trisomy 21 on DNA Methylation and Its Implications for Hematologic Malignancies Blood. 134: 2510-2510. DOI: 10.1182/Blood-2019-131455  0.385
2019 Lu Y, Gooden G, Tew BY, Buckley D, Siegmund K, Daneshmand S, Goldkorn A, Salhia B. Abstract 2274: Whole-genome bisulfite sequencing of cell-free DNA (cfDNA) in muscle-invasive bladder cancer patients to predict the risk of recurrence Cancer Research. 79: 2274-2274. DOI: 10.1158/1538-7445.Sabcs18-2274  0.412
2018 Ryser MD, Yu M, Grady W, Siegmund K, Shibata D. Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance. Scientific Reports. 8: 17292. PMID 30470817 DOI: 10.1038/S41598-018-35621-Y  0.34
2018 Gao L, Urman R, Millstein J, Siegmund KD, Dubeau L, Breton CV. Association between AXL promoter methylation and lung function growth during adolescence. Epigenetics. PMID 30277126 DOI: 10.1080/15592294.2018.1529517  0.374
2018 Park SL, Patel YM, Loo LWM, Mullen DJ, Offringa IA, Maunakea A, Stram DO, Siegmund K, Murphy SE, Tiirikainen M, Le Marchand L. Association of internal smoking dose with blood DNA methylation in three racial/ethnic populations. Clinical Epigenetics. 10: 110. PMID 30139389 DOI: 10.1186/S13148-018-0543-7  0.364
2018 Gao L, Liu X, Millstein J, Siegmund KD, Dubeau L, Maguire RL, Jim Zhang J, Fuemmeler BF, Kollins SH, Hoyo C, Murphy SK, Breton CV. Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes. Clinical Epigenetics. 10: 98. PMID 30029617 DOI: 10.1186/S13148-018-0532-X  0.35
2018 Ryser MD, Min BH, Siegmund KD, Shibata D. Spatial mutation patterns as markers of early colorectal tumor cell mobility. Proceedings of the National Academy of Sciences of the United States of America. PMID 29760052 DOI: 10.1073/Pnas.1716552115  0.312
2018 Mullen DJ, Stueve TR, Yan C, Siegmund KD, Laird-Offringa IA. Abstract A08: Widespread tobacco smoking-associated changes in DNA methylation and gene expression in lung tissue of smokers Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Aacriaslc18-A08  0.379
2017 Byun HM, Eshaghian S, Douer D, Trent J, Garcia-Manero G, Bhatia R, Siegmund K, Yang AS. Impact of Chromosomal Rearrangement upon DNA Methylation Patterns in Leukemia. Open Medicine (Warsaw, Poland). 12: 76-85. PMID 28730166 DOI: 10.1515/med-2017-0014  0.333
2017 Zhao J, Salomon MP, Shibata D, Curtis C, Siegmund K, Marjoram P. Early mutation bursts in colorectal tumors. Plos One. 12: e0172516. PMID 28257429 DOI: 10.1371/Journal.Pone.0172516  0.326
2017 Mundbjerg K, Chopra S, Alemozaffar M, Duymich C, Lakshminarasimhan R, Nichols PW, Aron M, Siegmund KD, Ukimura O, Aron M, Stern M, Gill P, Carpten JD, Ørntoft TF, Sørensen KD, et al. Identifying aggressive prostate cancer foci using a DNA methylation classifier. Genome Biology. 18: 3. PMID 28081708 DOI: 10.1186/S13059-016-1129-3  0.319
2016 Breton CV, Gao L, Yao J, Siegmund KD, Lurmann F, Gilliland F. Particulate matter, the newborn methylome, and cardio-respiratory health outcomes in childhood. Environmental Epigenetics. 2: dvw005. PMID 29492287 DOI: 10.1093/Eep/Dvw005  0.355
2016 Chopra S, Liu J, Alemozaffar M, Nichols PW, Aron M, Weisenberger DJ, Collings CK, Syan S, Hu B, Desai M, Aron M, Duddalwar V, Gill I, Liang G, Siegmund KD. Improving needle biopsy accuracy in small renal mass using tumor-specific DNA methylation markers. Oncotarget. PMID 27690297 DOI: 10.18632/Oncotarget.12276  0.308
2016 Liu J, Siegmund KD. An evaluation of processing methods for HumanMethylation450 BeadChip data. Bmc Genomics. 17: 469. PMID 27334613 DOI: 10.1186/S12864-016-2819-7  0.301
2016 Breton CV, Yao J, Millstein J, Gao L, Siegmund KD, Mack W, Whitfield-Maxwell L, Lurmann F, Hodis H, Avol E, Gilliland FD. Prenatal Air Pollution Exposures, DNA Methyl Transferase Genotypes, and Associations with Newborn LINE1 and Alu Methylation and Childhood Blood Pressure and Carotid Intima-Media Thickness in the Children's Health Study. Environmental Health Perspectives. PMID 27219456 DOI: 10.1289/Ehp181  0.326
2016 Becket E, Chopra S, Duymich CE, Lin JJ, You JS, Pandiyan K, Nichols PW, Siegmund KD, Charlet J, Weisenberger DJ, Jones PA, Liang G. Identification of DNA methylation-independent epigenetic events underlying clear cell renal cell carcinoma. Cancer Research. PMID 26759245 DOI: 10.1158/0008-5472.Can-15-2622  0.456
2016 Becket E, Chopra S, Duymich C, Justin LJ, You JS, Pandiyan K, Nichols PW, Siegmund KD, Jones PA, Liang G. Abstract B03: Identification of epigenetic regulated genes through simultaneous analysis of DNA methylation and chromatin structure in uncultured tumors Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-B03  0.46
2015 Kang H, Salomon MP, Sottoriva A, Zhao J, Toy M, Press MF, Curtis C, Marjoram P, Siegmund K, Shibata D. Many private mutations originate from the first few divisions of a human colorectal adenoma. The Journal of Pathology. PMID 26119426 DOI: 10.1002/Path.4581  0.313
2015 Sottoriva A, Kang H, Ma Z, Graham TA, Salomon MP, Zhao J, Marjoram P, Siegmund K, Press MF, Shibata D, Curtis C. A Big Bang model of human colorectal tumor growth. Nature Genetics. 47: 209-16. PMID 25665006 DOI: 10.1038/Ng.3214  0.304
2015 Weisenberger DJ, Levine AJ, Long TI, Buchanan DD, Walters R, Clendenning M, Rosty C, Joshi AD, Stern MC, Le Marchand L, Lindor NM, Daftary D, Gallinger S, Selander T, Bapat B, ... ... Siegmund KD, et al. Association of the colorectal CpG island methylator phenotype with molecular features, risk factors, and family history. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 24: 512-9. PMID 25587051 DOI: 10.1158/1055-9965.Epi-14-1161  0.436
2014 Breton CV, Siegmund KD, Joubert BR, Wang X, Qui W, Carey V, Nystad W, Håberg SE, Ober C, Nicolae D, Barnes KC, Martinez F, Liu A, Lemanske R, Strunk R, et al. Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation. Plos One. 9: e99716. PMID 24964093 DOI: 10.1371/Journal.Pone.0099716  0.321
2014 Wang X, Laird PW, Hinoue T, Groshen S, Siegmund KD. Non-specific filtering of beta-distributed data. Bmc Bioinformatics. 15: 199. PMID 24943962 DOI: 10.1186/1471-2105-15-199  0.313
2014 Zhao J, Siegmund KD, Shibata D, Marjoram P. Ancestral inference in tumors: how much can we know? Journal of Theoretical Biology. 359: 136-45. PMID 24907673 DOI: 10.1016/J.Jtbi.2014.05.027  0.33
2014 Su SF, de Castro Abreu AL, Chihara Y, Tsai Y, Andreu-Vieyra C, Daneshmand S, Skinner EC, Jones PA, Siegmund KD, Liang G. A panel of three markers hyper- and hypomethylated in urine sediments accurately predicts bladder cancer recurrence. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 1978-89. PMID 24691641 DOI: 10.1158/1078-0432.Ccr-13-2637  0.363
2014 Shi J, Marconett CN, Duan J, Hyland PL, Li P, Wang Z, Wheeler W, Zhou B, Campan M, Lee DS, Huang J, Zhou W, Triche T, Amundadottir L, Warner A, ... ... Siegmund KD, et al. Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. Nature Communications. 5: 3365. PMID 24572595 DOI: 10.1038/Ncomms4365  0.542
2014 Shi J, Marconett C, Duan J, Hyland P, Li P, Wang Z, Wheeler W, Campan M, Huang J, Zhou W, Triche T, Amundadottir L, Hutchinson A, Chen P, Zhou B, ... ... Siegmund K, et al. Abstract 287: Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue Cancer Research. 74: 287-287. DOI: 10.1158/1538-7445.Am2014-287  0.492
2013 Michels KB, Binder AM, Dedeurwaerder S, Epstein CB, Greally JM, Gut I, Houseman EA, Izzi B, Kelsey KT, Meissner A, Milosavljevic A, Siegmund KD, Bock C, Irizarry RA. Recommendations for the design and analysis of epigenome-wide association studies. Nature Methods. 10: 949-55. PMID 24076989 DOI: 10.1038/Nmeth.2632  0.327
2013 Thomas JP, Davis-Dao C, Lewinger JP, Siegmund KD, Hamilton AS, Daneshmand S, Skinner EC, Thomas DC, Cortessis VK. Null association between histology of first and second primary malignancies in men with bilateral testicular germ cell tumors. American Journal of Epidemiology. 178: 1240-5. PMID 23928263 DOI: 10.1093/Aje/Kwt100  0.329
2013 Marconett CN, Zhou B, Rieger ME, Selamat SA, Dubourd M, Fang X, Lynch SK, Stueve TR, Siegmund KD, Berman BP, Borok Z, Laird-Offringa IA. Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation. Plos Genetics. 9: e1003513. PMID 23818859 DOI: 10.1371/Journal.Pgen.1003513  0.314
2013 Triche TJ, Weisenberger DJ, Van Den Berg D, Laird PW, Siegmund KD. Low-level processing of Illumina Infinium DNA Methylation BeadArrays. Nucleic Acids Research. 41: e90. PMID 23476028 DOI: 10.1093/Nar/Gkt090  0.492
2013 Schumacher FR, Wang Z, Skotheim RI, Koster R, Chung CC, Hildebrandt MA, Kratz CP, Bakken AC, Bishop DT, Cook MB, Erickson RL, FossÃ¥ SD, Greene MH, Jacobs KB, Kanetsky PA, ... ... Siegmund KD, et al. Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23. Human Molecular Genetics. 22: 2748-53. PMID 23462292 DOI: 10.1093/Hmg/Ddt109  0.317
2013 Abreu ALdC, Su S, Siegmund K, Tsai Y, Chihara Y, Skinner E, Daneshmand S, Jones PA, Liang G. 1699 Identifying Novel Dna Methylation Markers To Monitor Bladder Cancer Recurrence In Urine Sediments From Turbt Patients The Journal of Urology. 189. DOI: 10.1016/J.Juro.2013.02.3009  0.325
2012 Liu Y, Siegmund KD, Laird PW, Berman BP. Bis-SNP: combined DNA methylation and SNP calling for Bisulfite-seq data. Genome Biology. 13: R61. PMID 22784381 DOI: 10.1186/Gb-2012-13-7-R61  0.351
2012 Cortessis VK, Thomas DC, Levine AJ, Breton CV, Mack TM, Siegmund KD, Haile RW, Laird PW. Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Human Genetics. 131: 1565-89. PMID 22740325 DOI: 10.1007/S00439-012-1189-8  0.358
2012 Selamat SA, Chung BS, Girard L, Zhang W, Zhang Y, Campan M, Siegmund KD, Koss MN, Hagen JA, Lam WL, Lam S, Gazdar AF, Laird-Offringa IA. Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Research. 22: 1197-211. PMID 22613842 DOI: 10.1101/Gr.132662.111  0.437
2012 Breton CV, Salam MT, Wang X, Byun HM, Siegmund KD, Gilliland FD. Particulate matter, DNA methylation in nitric oxide synthase, and childhood respiratory disease. Environmental Health Perspectives. 120: 1320-6. PMID 22591701 DOI: 10.1289/Ehp.1104439  0.377
2012 Wang J, Joshi AD, Corral R, Siegmund KD, Marchand LL, Martinez ME, Haile RW, Ahnen DJ, Sandler RS, Lance P, Stern MC. Carcinogen metabolism genes, red meat and poultry intake, and colorectal cancer risk. International Journal of Cancer. Journal International Du Cancer. 130: 1898-907. PMID 21618522 DOI: 10.1002/Ijc.26199  0.323
2011 Campan M, Moffitt M, Houshdaran S, Shen H, Widschwendter M, Daxenbichler G, Long T, Marth C, Laird-Offringa IA, Press MF, Dubeau L, Siegmund KD, Wu AH, Groshen S, Chandavarkar U, et al. Genome-scale screen for DNA methylation-based detection markers for ovarian cancer. Plos One. 6: e28141. PMID 22163280 DOI: 10.1371/Journal.Pone.0028141  0.411
2011 Cortessis VK, Siegmund K, Houshdaran S, Laird PW, Sokol RZ. Repeated assessment by high-throughput assay demonstrates that sperm DNA methylation levels are highly reproducible. Fertility and Sterility. 96: 1325-30. PMID 22035967 DOI: 10.1016/J.Fertnstert.2011.09.036  0.393
2011 Wang X, Kang GH, Campan M, Weisenberger DJ, Long TI, Cozen W, Bernstein L, Wu AH, Siegmund KD, Shibata D, Laird PW. Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors. Plos One. 6: e25985. PMID 22028801 DOI: 10.1371/Journal.Pone.0025985  0.398
2011 Rakovski C, Weisenberger DJ, Marjoram P, Laird PW, Siegmund KD. Modeling measurement error in tumor characterization studies. Bmc Bioinformatics. 12: 284. PMID 21752297 DOI: 10.1186/1471-2105-12-284  0.433
2011 Siegmund KD, Marjoram P, Tavaré S, Shibata D. High DNA methylation pattern intratumoral diversity implies weak selection in many human colorectal cancers. Plos One. 6: e21657. PMID 21738754 DOI: 10.1371/Journal.Pone.0021657  0.367
2011 Selamat SA, Galler JS, Joshi AD, Fyfe MN, Campan M, Siegmund KD, Kerr KM, Laird-Offringa IA. DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma. Plos One. 6: e21443. PMID 21731750 DOI: 10.1371/Journal.Pone.0021443  0.42
2011 Davis-Dao CA, Siegmund KD, Vandenberg DJ, Skinner EC, Coetzee GA, Thomas DC, Pike MC, Cortessis VK. Heterogenous effect of androgen receptor CAG tract length on testicular germ cell tumor risk: shorter repeats associated with seminoma but not other histologic types. Carcinogenesis. 32: 1238-43. PMID 21642359 DOI: 10.1093/Carcin/Bgr104  0.341
2011 Siegmund KD. Statistical approaches for the analysis of DNA methylation microarray data. Human Genetics. 129: 585-95. PMID 21519831 DOI: 10.1007/S00439-011-0993-X  0.405
2011 Kastrinos F, Steyerberg EW, Mercado R, Balmaña J, Holter S, Gallinger S, Siegmund KD, Church JM, Jenkins MA, Lindor NM, Thibodeau SN, Burbidge LA, Wenstrup RJ, Syngal S. The PREMM(1,2,6) model predicts risk of MLH1, MSH2, and MSH6 germline mutations based on cancer history. Gastroenterology. 140: 73-81. PMID 20727894 DOI: 10.1053/J.Gastro.2010.08.021  0.318
2010 Brevik A, Joshi AD, Corral R, Onland-Moret NC, Siegmund KD, Le Marchand L, Baron JA, Martinez ME, Haile RW, Ahnen DJ, Sandler RS, Lance P, Stern MC. Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 19: 3167-73. PMID 21037106 DOI: 10.1158/1055-9965.Epi-10-0606  0.332
2010 Wolff EM, Chihara Y, Pan F, Weisenberger DJ, Siegmund KD, Sugano K, Kawashima K, Laird PW, Jones PA, Liang G. Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue. Cancer Research. 70: 8169-78. PMID 20841482 DOI: 10.1158/0008-5472.Can-10-1335  0.418
2010 Hong YJ, Marjoram P, Shibata D, Siegmund KD. Using DNA methylation patterns to infer tumor ancestry. Plos One. 5: e12002. PMID 20711251 DOI: 10.1371/Journal.Pone.0012002  0.424
2010 Wolff EM, Byun HM, Han HF, Sharma S, Nichols PW, Siegmund KD, Yang AS, Jones PA, Liang G. Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer. Plos Genetics. 6: e1000917. PMID 20421991 DOI: 10.1371/Journal.Pgen.1000917  0.323
2010 Wang XM, Greiner TC, Bibikova M, Pike BL, Siegmund KD, Sinha UK, Müschen M, Jaeger EB, Weisenburger DD, Chan WC, Shibata D, Fan JB, Hacia JG. Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations. Journal of Cellular Biochemistry. 109: 818-27. PMID 20069569 DOI: 10.1002/Jcb.22461  0.454
2010 Wu AH, Siegmund KD, Long TI, Cozen W, Wan P, Tseng CC, Shibata D, Laird PW. Hormone therapy, DNA methylation and colon cancer. Carcinogenesis. 31: 1060-7. PMID 20064828 DOI: 10.1093/Carcin/Bgq009  0.395
2010 Liang G, Wolff EM, Han HF, Byun H, Sharma S, Nichols P, Siegmund KD, Jones PA. Abstract 4801: Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer Cancer Research. 70: 4801-4801. DOI: 10.1158/1538-7445.Am10-4801  0.345
2010 Cozen W, Wang J, Siegmund K, Triche T, Weisenberger D, Berg DVD, Hamilton A, Hwang A, Mack TM. Abstract 155: A comparison of DNA methylation in identical twins discordant for Hodgkin lymphoma Cancer Research. 70: 155-155. DOI: 10.1158/1538-7445.Am10-155  0.542
2009 Byun HM, Siegmund KD, Pan F, Weisenberger DJ, Kanel G, Laird PW, Yang AS. Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns. Human Molecular Genetics. 18: 4808-17. PMID 19776032 DOI: 10.1093/Hmg/Ddp445  0.426
2009 Poynter JN, Haile RW, Siegmund KD, Campbell PT, Figueiredo JC, Limburg P, Young J, Le Marchand L, Potter JD, Cotterchio M, Casey G, Hopper JL, Jenkins MA, Thibodeau SN, Newcomb PA, et al. Associations between smoking, alcohol consumption, and colorectal cancer, overall and by tumor microsatellite instability status. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 18: 2745-50. PMID 19755657 DOI: 10.1158/1055-9965.Epi-09-0517  0.316
2009 Siegmund KD, Marjoram P, Tavaré S, Shibata D. Many colorectal cancers are "flat" clonal expansions. Cell Cycle (Georgetown, Tex.). 8: 2187-93. PMID 19556889 DOI: 10.4161/Cc.8.14.9151  0.378
2009 Siegmund KD, Marjoram P, Woo YJ, Tavaré S, Shibata D. Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers. Proceedings of the National Academy of Sciences of the United States of America. 106: 4828-33. PMID 19261858 DOI: 10.1073/Pnas.0810276106  0.414
2009 Woo YJ, Siegmund KD, Tavaré S, Shibata D. Older individuals appear to acquire mitotically older colorectal cancers. The Journal of Pathology. 217: 483-8. PMID 19165870 DOI: 10.1002/Path.2506  0.355
2009 Joshi AD, Corral R, Siegmund KD, Haile RW, Le Marchand L, Martínez ME, Ahnen DJ, Sandler RS, Lance P, Stern MC. Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk. Carcinogenesis. 30: 472-9. PMID 19029193 DOI: 10.1093/Carcin/Bgn260  0.328
2009 Siegmund KD. DNA Methylation Microarrays: Experimental Design and Statistical Analysis by WANG, S.‐C. and PETRONIS, A. Biometrics. 65: 332-333. DOI: 10.1111/J.1541-0420.2009.01208_7.X  0.369
2008 Poynter JN, Siegmund KD, Weisenberger DJ, Long TI, Thibodeau SN, Lindor N, Young J, Jenkins MA, Hopper JL, Baron JA, Buchanan D, Casey G, Levine AJ, Le Marchand L, Gallinger S, et al. Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 17: 3208-15. PMID 18990764 DOI: 10.1158/1055-9965.Epi-08-0512  0.37
2008 Magda D, Lecane P, Prescott J, Thiemann P, Ma X, Dranchak PK, Toleno DM, Ramaswamy K, Siegmund KD, Hacia JG. mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft. Bmc Genomics. 9: 521. PMID 18980691 DOI: 10.1186/1471-2164-9-521  0.319
2008 Anglim PP, Galler JS, Koss MN, Hagen JA, Turla S, Campan M, Weisenberger DJ, Laird PW, Siegmund KD, Laird-Offringa IA. Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer. Molecular Cancer. 7: 62. PMID 18616821 DOI: 10.1186/1476-4598-7-62  0.435
2008 Siegmund KD, Marjoram P, Shibata D. Modeling DNA methylation in a population of cancer cells. Statistical Applications in Genetics and Molecular Biology. 7: Article 18. PMID 18597664 DOI: 10.2202/1544-6115.1374  0.429
2008 Chu M, Siegmund KD, Hao QL, Crooks GM, Tavaré S, Shibata D. Inferring relative numbers of human leucocyte genome replications. British Journal of Haematology. 141: 862-71. PMID 18410448 DOI: 10.1111/J.1365-2141.2008.07142.X  0.352
2008 Pike BL, Greiner TC, Wang X, Weisenburger DD, Hsu YH, Renaud G, Wolfsberg TG, Kim M, Weisenberger DJ, Siegmund KD, Ye W, Groshen S, Mehrian-Shai R, Delabie J, Chan WC, et al. DNA methylation profiles in diffuse large B-cell lymphoma and their relationship to gene expression status. Leukemia. 22: 1035-43. PMID 18288132 DOI: 10.1038/Leu.2008.18  0.412
2007 Houshdaran S, Cortessis VK, Siegmund K, Yang A, Laird PW, Sokol RZ. Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm. Plos One. 2: e1289. PMID 18074014 DOI: 10.1371/Journal.Pone.0001289  0.399
2007 Poynter JN, Figueiredo JC, Conti DV, Kennedy K, Gallinger S, Siegmund KD, Casey G, Thibodeau SN, Jenkins MA, Hopper JL, Byrnes GB, Baron JA, Goode EL, Tiirikainen M, Lindor N, et al. Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry. Cancer Research. 67: 11128-32. PMID 18056436 DOI: 10.1158/0008-5472.Can-07-3239  0.34
2007 Stern MC, Conti DV, Siegmund KD, Corral R, Yuan JM, Koh WP, Yu MC. DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 16: 2363-72. PMID 18006925 DOI: 10.1158/1055-9965.Epi-07-0268  0.338
2007 Tsou JA, Galler JS, Siegmund KD, Laird PW, Turla S, Cozen W, Hagen JA, Koss MN, Laird-Offringa IA. Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma. Molecular Cancer. 6: 70. PMID 17967182 DOI: 10.1186/1476-4598-6-70  0.394
2007 Siegmund KD, Connor CM, Campan M, Long TI, Weisenberger DJ, Biniszkiewicz D, Jaenisch R, Laird PW, Akbarian S. DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. Plos One. 2: e895. PMID 17878930 DOI: 10.1371/Journal.Pone.0000895  0.399
2007 Chu MW, Siegmund KD, Eckstam CL, Kim JY, Yang AS, Kanel GC, Tavaré S, Shibata D. Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging. Bmc Medical Genetics. 8: 50. PMID 17672908 DOI: 10.1186/1471-2350-8-50  0.394
2007 Tsou JA, Galler JS, Wali A, Ye W, Siegmund KD, Groshen S, Laird PW, Turla S, Koss MN, Pass HI, Laird-Offringa IA. DNA methylation profile of 28 potential marker loci in malignant mesothelioma. Lung Cancer (Amsterdam, Netherlands). 58: 220-30. PMID 17659810 DOI: 10.1016/J.Lungcan.2007.06.015  0.448
2007 Alonzo TA, Siegmund KD. Statistical methods for evaluating DNA methylation as a marker for early detection or prognosis. Disease Markers. 23: 113-20. PMID 17325431 DOI: 10.1155/2007/308573  0.364
2007 Cortessis V, Houshdaran S, Siegmund K, Yang A, Laird P, Sokol R. A broad epigenetic defect of abnormal human sperm is suggested by elevated methylation of numerous DNA sequences in sperm of low concentration, poor morphology and poor motility Fertility and Sterility. 88: S68. DOI: 10.1016/J.Fertnstert.2007.07.229  0.348
2006 Marjoram P, Chang J, Laird PW, Siegmund KD. Cluster analysis for DNA methylation profiles having a detection threshold. Bmc Bioinformatics. 7: 361. PMID 16872497 DOI: 10.1186/1471-2105-7-361  0.384
2006 Weisenberger DJ, Siegmund KD, Campan M, Young J, Long TI, Faasse MA, Kang GH, Widschwendter M, Weener D, Buchanan D, Koh H, Simms L, Barker M, Leggett B, Levine J, et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nature Genetics. 38: 787-93. PMID 16804544 DOI: 10.1038/Ng1834  0.43
2006 Siegmund KD, Levine AJ, Chang J, Laird PW. Modeling exposures for DNA methylation profiles. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 567-72. PMID 16537717 DOI: 10.1158/1055-9965.Epi-05-0717  0.345
2006 Tsou J, Galler J, Wali A, Pass H, Siegmund K, Ye W, Groshen S, Weisenberger D, Campan M, Laird P, Turla S, Koss M, Laird-Offringa I. 147 DNA methylation profile of 28 candidate marker loci in malignant mesothelioma Lung Cancer. 54: S36. DOI: 10.1016/S0169-5002(07)70223-4  0.406
2005 Millstein J, Siegmund KD, Conti DV, Gauderman WJ. Identifying susceptibility genes by using joint tests of association and linkage and accounting for epistasis. Bmc Genetics. 6: S147. PMID 16451607 DOI: 10.1186/1471-2156-6-S1-S147  0.301
2005 Friedrich MG, Chandrasoma S, Siegmund KD, Weisenberger DJ, Cheng JC, Toma MI, Huland H, Jones PA, Liang G. Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma. European Journal of Cancer (Oxford, England : 1990). 41: 2769-78. PMID 16242928 DOI: 10.1016/J.Ejca.2005.07.019  0.406
2005 Kim JY, Siegmund KD, Tavaré S, Shibata D. Age-related human small intestine methylation: evidence for stem cell niches. Bmc Medicine. 3: 10. PMID 15975143 DOI: 10.1186/1741-7015-3-10  0.305
2005 Tsou JA, Shen LY, Siegmund KD, Long TI, Laird PW, Seneviratne CK, Koss MN, Pass HI, Hagen JA, Laird-Offringa IA. Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-tumor lung. Lung Cancer (Amsterdam, Netherlands). 47: 193-204. PMID 15639718 DOI: 10.1016/J.Lungcan.2004.08.003  0.428
2004 Friedrich MG, Weisenberger DJ, Cheng JC, Chandrasoma S, Siegmund KD, Gonzalgo ML, Toma MI, Huland H, Yoo C, Tsai YC, Nichols PW, Bochner BH, Jones PA, Liang G. Detection of methylated apoptosis-associated genes in urine sediments of bladder cancer patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 7457-65. PMID 15569975 DOI: 10.1158/1078-0432.Ccr-04-0930  0.44
2004 Siegmund KD, Laird PW, Laird-Offringa IA. A comparison of cluster analysis methods using DNA methylation data. Bioinformatics (Oxford, England). 20: 1896-904. PMID 15044245 DOI: 10.1093/Bioinformatics/Bth176  0.402
2004 Friedrich MG, Liang G, Toma MI, Weisenberger DJ, Cheng JC, Siegmund KD, Huland H, Jones PA. 743: Methylation of the E-Cadherin and the TIMP-3 Genes are Positive Prognostic Markers for Patients with Non-Muscle Invasive Bladder Carcinoma Journal of Urology. 171: 197-197. DOI: 10.1016/S0022-5347(18)37992-8  0.305
2003 Cortessis VK, Siegmund K, Xue S, Ross RK, Yu MC. A case-control study of cyclin D1 CCND1 870A-->G polymorphism and bladder cancer. Carcinogenesis. 24: 1645-50. PMID 12896908 DOI: 10.1093/Carcin/Bgg128  0.347
2002 Tsao JL, Dudley S, Kwok B, Nickel AE, Laird PW, Siegmund KD, Liskay RM, Shibata D. Diet, cancer and aging in DNA mismatch repair deficient mice. Carcinogenesis. 23: 1807-10. PMID 12419828 DOI: 10.1093/Carcin/23.11.1807  0.308
2002 Siegmund KD, Laird PW. Analysis of complex methylation data. Methods (San Diego, Calif.). 27: 170-8. PMID 12095277 DOI: 10.1016/S1046-2023(02)00071-3  0.389
2002 Virmani AK, Tsou JA, Siegmund KD, Shen LY, Long TI, Laird PW, Gazdar AF, Laird-Offringa IA. Hierarchical clustering of lung cancer cell lines using DNA methylation markers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 11: 291-7. PMID 11895880  0.3
2000 Siegmund KD, Todorov AA. Linkage analysis for diseases with variable age of onset. Human Heredity. 50: 205-10. PMID 10686502 DOI: 10.1159/000022916  0.308
1999 Siegmund KD, Gauderman WJ, Thomas DC. Association tests using unaffected-sibling versus pseudo-sibling controls. Genetic Epidemiology. 17: S731-6. PMID 10597522 DOI: 10.1002/Gepi.13701707120  0.321
1998 Siegmund K, McKnight B. Modeling hazard functions in families Genetic Epidemiology. 15: 147-171. PMID 9554553 DOI: 10.1002/(Sici)1098-2272(1998)15:2<147::Aid-Gepi4>3.0.Co;2-3  0.308
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