Joerg Langowski, Dr. rer. nat. - Publications

Affiliations: 
Biophysics of Macromolecules German Cancer Research Center, Heidelberg, Baden-Württemberg, Germany 
Area:
Biophysics, single molecule spectroscopy, computational biology

79 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Lehmann K, Felekyan S, Kühnemuth R, Dimura M, Tóth K, Seidel CAM, Langowski J. Dynamics of the nucleosomal histone H3 N-terminal tail revealed by high precision single-molecule FRET. Nucleic Acids Research. PMID 31956896 DOI: 10.1093/nar/gkz1186  0.402
2018 Gansen A, Felekyan S, Kühnemuth R, Lehmann K, Tóth K, Seidel CAM, Langowski J. High precision FRET studies reveal reversible transitions in nucleosomes between microseconds and minutes. Nature Communications. 9: 4628. PMID 30401903 DOI: 10.1038/s41467-018-06758-1  0.4
2017 Rubio-Cosials A, Battistini F, Gansen A, Cuppari A, Bernadó P, Orozco M, Langowski J, Tóth K, Solà M. Protein Flexibility and Synergy of HMG Domains Underlie U-Turn Bending of DNA by TFAM in Solution. Biophysical Journal. PMID 29248151 DOI: 10.1016/J.Bpj.2017.11.3743  0.428
2017 Sauer PV, Timm J, Liu D, Sitbon D, Boeri-Erba E, Velours C, Mücke N, Langowski J, Ochsenbein F, Almouzni G, Panne D. Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1. Elife. 6. PMID 28315525 DOI: 10.7554/Elife.23474  0.347
2015 Hazan NP, Tomov TE, Tsukanov R, Liber M, Berger Y, Masoud R, Toth K, Langowski J, Nir E. Nucleosome Core Particle Disassembly and Assembly Kinetics Studied Using Single-Molecule Fluorescence. Biophysical Journal. 109: 1676-85. PMID 26488658 DOI: 10.1016/J.Bpj.2015.07.004  0.434
2015 Gansen A, Tóth K, Schwarz N, Langowski J. Opposing roles of H3- and H4-acetylation in the regulation of nucleosome structure––a FRET study. Nucleic Acids Research. 43: 1433-43. PMID 25589544 DOI: 10.1093/nar/gku1354  0.322
2015 Elbel T, Langowski J. The effect of DNA supercoiling on nucleosome structure and stability. Journal of Physics. Condensed Matter : An Institute of Physics Journal. 27: 064105. PMID 25563201 DOI: 10.1088/0953-8984/27/6/064105  0.457
2014 Erler J, Zhang R, Petridis L, Cheng X, Smith JC, Langowski J. The role of histone tails in the nucleosome: a computational study. Biophysical Journal. 107: 2911-22. PMID 25517156 DOI: 10.1016/J.Bpj.2014.10.065  0.353
2014 Hieb AR, Gansen A, Böhm V, Langowski J. The conformational state of the nucleosome entry-exit site modulates TATA box-specific TBP binding Nucleic Acids Research. 42: 7561-7576. PMID 24829456 DOI: 10.1093/nar/gku423  0.743
2013 Waldeck W, Mueller G, Glatting KH, Hotz-Wagenblatt A, Diessl N, Chotewutmonti S, Langowski J, Semmler W, Wiessler M, Braun K. Spatial localization of genes determined by intranuclear DNA fragmentation with the fusion proteins lamin KRED and histone KRED und visible light. International Journal of Medical Sciences. 10: 1136-48. PMID 23869190 DOI: 10.7150/ijms.6121  0.317
2013 Tóth K, Böhm V, Sellmann C, Danner M, Hanne J, Berg M, Barz I, Gansen A, Langowski J. Histone- and DNA sequence-dependent stability of nucleosomes studied by single-pair FRET. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 83: 839-46. PMID 23843180 DOI: 10.1002/cyto.a.22320  0.423
2013 Gansen A, Hieb AR, Böhm V, Tóth K, Langowski J. Closing the gap between single molecule and bulk FRET analysis of nucleosomes. Plos One. 8: e57018. PMID 23637734 DOI: 10.1371/Journal.Pone.0057018  0.709
2012 Voltz K, Trylska J, Calimet N, Smith JC, Langowski J. Unwrapping of nucleosomal DNA ends: a multiscale molecular dynamics study. Biophysical Journal. 102: 849-58. PMID 22385856 DOI: 10.1016/J.Bpj.2011.11.4028  0.468
2012 Biswas M, Wocjan T, Langowski J, Smith JC. DNA bending potentials for loop-mediated nucleosome repositioning Epl. 97. DOI: 10.1209/0295-5075/97/38004  0.533
2012 Biswas M, Langowski J, Smith JC. Structural Alterations in the Nucleosome upon H3 Tail-Truncation Reveals a Crucial Role for the H2A C Terminal Docking Domain in Nucleosome Destabilization Biophysical Journal. 102: 73a. DOI: 10.1016/J.Bpj.2011.11.428  0.354
2011 Winheim S, Hieb AR, Silbermann M, Surmann EM, Wedig T, Herrmann H, Langowski J, Mücke N. Deconstructing the late phase of vimentin assembly by total internal reflection fluorescence microscopy (TIRFM) Plos One. 6. PMID 21544245 DOI: 10.1371/Journal.Pone.0019202  0.683
2011 Böhm V, Hieb AR, Andrews AJ, Gansen A, Rocker A, Tóth K, Luger K, Langowski J. Nucleosome accessibility governed by the dimer/tetramer interface. Nucleic Acids Research. 39: 3093-102. PMID 21177647 DOI: 10.1093/Nar/Gkq1279  0.754
2011 Elbel T, Langowski J. Atomic Force Microscopy Studies on the Effect of DNA Supercoiling on Nucleosome Structure Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.577  0.526
2010 Diesinger PM, Kunkel S, Langowski J, Heermann DW. Histone depletion facilitates chromatin loops on the kilobasepair scale. Biophysical Journal. 99: 2995-3001. PMID 21044597 DOI: 10.1016/j.bpj.2010.08.039  0.306
2010 Biswas M, Langowski J, Smith JC. DNA Loop Formation in Nucleosomes Biophysical Journal. 98: 476a. DOI: 10.1016/J.Bpj.2009.12.2593  0.544
2009 Wocjan T, Krieger J, Krichevsky O, Langowski J. Dynamics of a fluorophore attached to superhelical DNA: FCS experiments simulated by Brownian dynamics. Physical Chemistry Chemical Physics : Pccp. 11: 10671-81. PMID 20145811 DOI: 10.1039/B911857H  0.404
2009 Wocjan T, Klenin K, Langowski J. Brownian dynamics simulation of DNA unrolling from the nucleosome. The Journal of Physical Chemistry. B. 113: 2639-46. PMID 19708203 DOI: 10.1021/jp806137e  0.385
2009 Gansen A, Valeri A, Hauger F, Felekyan S, Kalinin S, Tóth K, Langowski J, Seidel CA. Nucleosome disassembly intermediates characterized by single-molecule FRET. Proceedings of the National Academy of Sciences of the United States of America. 106: 15308-13. PMID 19706432 DOI: 10.1073/pnas.0903005106  0.376
2009 Gansen A, Tóth K, Schwarz N, Langowski J. Structural variability of nucleosomes detected by single-pair Förster resonance energy transfer: histone acetylation, sequence variation, and salt effects. The Journal of Physical Chemistry. B. 113: 2604-13. PMID 18950220 DOI: 10.1021/jp7114737  0.401
2008 Poirier MG, Bussiek M, Langowski J, Widom J. Spontaneous access to DNA target sites in folded chromatin fibers. Journal of Molecular Biology. 379: 772-86. PMID 18485363 DOI: 10.1016/J.Jmb.2008.04.025  0.423
2008 Hoischen C, Bussiek M, Langowski J, Diekmann S. Escherichia coli low-copy-number plasmid R1 centromere parC forms a U-shaped complex with its binding protein ParR Nucleic Acids Research. 36: 607-615. PMID 18056157 DOI: 10.1093/nar/gkm672  0.401
2007 Langowski J, Heermann DW. Computational modeling of the chromatin fiber Seminars in Cell and Developmental Biology. 18: 659-667. PMID 17936653 DOI: 10.1016/j.semcdb.2007.08.011  0.302
2007 Bussiek M, Müller G, Waldeck W, Diekmann S, Langowski J. Organisation of nucleosomal arrays reconstituted with repetitive African green monkey alpha-satellite DNA as analysed by atomic force microscopy. European Biophysics Journal : Ebj. 37: 81-93. PMID 17503032 DOI: 10.1007/s00249-007-0166-y  0.408
2007 Jin H, Jeng ES, Heller DA, Jena PV, Kirmse R, Langowski J, Strano MS. Divalent ion and thermally induced DNA conformational polymorphism on single-walled carbon nanotubes Macromolecules. 40: 6731-6739. DOI: 10.1021/Ma070608T  0.612
2006 Bussiek M, Tóth K, Schwarz N, Langowski J. Trinucleosome compaction studied by fluorescence energy transfer and scanning force microscopy. Biochemistry. 45: 10838-46. PMID 16953569 DOI: 10.1021/bi060807p  0.334
2006 Egyeki M, Tóth K, Waldeck W, Schmezer P, Langowski J, Csík G. DNA damaging capability of hematoporphyrin towards DNAs of various accessibilities. Journal of Photochemistry and Photobiology. B, Biology. 84: 119-27. PMID 16549364 DOI: 10.1016/j.jphotobiol.2006.02.005  0.429
2006 Langowski J. Polymer chain models of DNA and chromatin. The European Physical Journal. E, Soft Matter. 19: 241-9. PMID 16547610 DOI: 10.1140/epje/i2005-10067-9  0.312
2006 Klenin KV, Merlitz H, Langowski J, Wu CX. Facilitated diffusion of DNA-binding proteins. Physical Review Letters. 96: 018104. PMID 16486524 DOI: 10.1103/PhysRevLett.96.018104  0.354
2006 Tóth K, Brun N, Langowski J. Chromatin compaction at the mononucleosome level. Biochemistry. 45: 1591-8. PMID 16460006 DOI: 10.1021/bi052110u  0.372
2005 Bussiek M, Tóth K, Brun N, Langowski J. DNA-loop formation on nucleosomes shown by in situ scanning force microscopy of supercoiled DNA. Journal of Molecular Biology. 345: 695-706. PMID 15588819 DOI: 10.1016/j.jmb.2004.11.016  0.443
2004 Lankas F, Sponer J, Langowski J, Cheatham TE. DNA deformability at the base pair level. Journal of the American Chemical Society. 126: 4124-5. PMID 15053599 DOI: 10.1021/Ja0390449  0.32
2003 Kepert JF, Tóth KF, Caudron M, Mücke N, Langowski J, Rippe K. Conformation of reconstituted mononucleosomes and effect of linker histone H1 binding studied by scanning force microscopy. Biophysical Journal. 85: 4012-22. PMID 14645090 DOI: 10.1016/S0006-3495(03)74815-2  0.369
2003 Bussiek M, Mücke N, Langowski J. Polylysine-coated mica can be used to observe systematic changes in the supercoiled DNA conformation by scanning force microscopy in solution Nucleic Acids Research. 31: e137. PMID 14602930  0.374
2003 Lankas F, Sponer J, Langowski J, Cheatham TE. DNA basepair step deformability inferred from molecular dynamics simulations. Biophysical Journal. 85: 2872-83. PMID 14581192 DOI: 10.1016/S0006-3495(03)74710-9  0.374
2002 Bussiek M, Klenin K, Langowski J. Kinetics of site-site interactions in supercoiled DNA with bent sequences. Journal of Molecular Biology. 322: 707-18. PMID 12270708 DOI: 10.1016/S0022-2836(02)00817-3  0.39
2002 Klenin K, Langowski J, Vologodskii A. Computational analysis of the chiral action of type II DNA topoisomerases. Journal of Molecular Biology. 320: 359-67. PMID 12079392 DOI: 10.1016/S0022-2836(02)00447-3  0.369
2001 Tóth K, Brun N, Langowski J. Trajectory of nucleosomal linker DNA studied by fluorescence resonance energy transfer Biochemistry. 40: 6921-6928. PMID 11389607 DOI: 10.1021/bi002695m  0.417
2001 Chirico G, Collini M, Tóth K, Brun N, Langowski J. Rotational dynamics of curved DNA fragments studied by fluorescence polarization anisotropy. European Biophysics Journal : Ebj. 29: 597-606. PMID 11288835 DOI: 10.1007/s002490000110  0.336
2000 Schulz A, Langowski J, Rippe K. The effect of the DNA conformation on the rate of NtrC activated transcription of Escherichia coli RNA polymerase.sigma(54) holoenzyme. Journal of Molecular Biology. 300: 709-25. PMID 10891265 DOI: 10.1006/jmbi.2000.3921  0.372
2000 Hammermann M, Tóth K, Rodemer C, Waldeck W, May RP, Langowski J. Salt-dependent compaction of di- and trinucleosomes studied by small-angle neutron scattering. Biophysical Journal. 79: 584-94. PMID 10866982 DOI: 10.1016/S0006-3495(00)76318-1  0.312
2000 Lankas F, Sponer J, Hobza P, Langowski J. Sequence-dependent elastic properties of DNA. Journal of Molecular Biology. 299: 695-709. PMID 10835278 DOI: 10.1006/Jmbi.2000.3781  0.331
1998 Hammermann M, Brun N, Klenin KV, May R, Tóth K, Langowski J. Salt-dependent DNA superhelix diameter studied by small angle neutron scattering measurements and Monte Carlo simulations. Biophysical Journal. 75: 3057-63. PMID 9826625 DOI: 10.1016/S0006-3495(98)77746-X  0.349
1998 Schulz A, Mücke N, Langowski J, Rippe K. Scanning force microscopy of Escherichia coli RNA polymerase.sigma54 holoenzyme complexes with DNA in buffer and in air. Journal of Molecular Biology. 283: 821-36. PMID 9790843 DOI: 10.1006/jmbi.1998.2131  0.384
1998 Klenin K, Merlitz H, Langowski J. A Brownian dynamics program for the simulation of linear and circular DNA and other wormlike chain polyelectrolytes. Biophysical Journal. 74: 780-8. PMID 9533691 DOI: 10.1016/S0006-3495(98)74003-2  0.381
1998 Merlitz H, Rippe K, Klenin KV, Langowski J. Looping dynamics of linear DNA molecules and the effect of DNA curvature: a study by Brownian dynamics simulation. Biophysical Journal. 74: 773-9. PMID 9533690 DOI: 10.1016/S0006-3495(98)74002-0  0.439
1998 Sevenich FW, Langowski J, Weiss V, Rippe K. DNA binding and oligomerization of NtrC studied by fluorescence anisotropy and fluorescence correlation spectroscopy Nucleic Acids Research. 26: 1373-1381. PMID 9490780 DOI: 10.1093/nar/26.6.1373  0.396
1998 Pfannschmidt C, Langowski J. Superhelix organization by DNA curvature as measured through site-specific labeling. Journal of Molecular Biology. 275: 601-11. PMID 9466934 DOI: 10.1006/jmbi.1997.1476  0.37
1998 Wedemann G, Münkel C, Schöppe G, Langowski J. Kinetics of structural changes in superhelical DNA Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics. 58: 3537-3546.  0.38
1997 Schätz T, Langowski J. Curvature and sequence analysis of eukaryotic promoters. Journal of Biomolecular Structure & Dynamics. 15: 265-75. PMID 9399154 DOI: 10.1080/07391102.1997.10508191  0.343
1997 Hammermann M, Steinmaier C, Merlitz H, Kapp U, Waldeck W, Chirico G, Langowski J. Salt effects on the structure and internal dynamics of superhelical DNAs studied by light scattering and Brownian dynamics. Biophysical Journal. 73: 2674-87. PMID 9370461 DOI: 10.1016/S0006-3495(97)78296-1  0.302
1997 Rippe K, Mücke N, Langowski J. Superhelix dimensions of a 1868 base pair plasmid determined by scanning force microscopy in air and in aqueous solution Nucleic Acids Research. 25: 1736-1744. PMID 9108155 DOI: 10.1093/nar/25.9.1736  0.331
1997 Längst G, Schätz T, Langowski J, Grummt I. Structural analysis of mouse rDNA: Coincidence between nuclease hypersensitive sites, DNA curvature and regulatory elements in the intergenic spacer Nucleic Acids Research. 25: 511-517. PMID 9016589 DOI: 10.1093/nar/25.3.511  0.307
1996 Langowski J, Olson WK, Pedersen SC, Tobias I, Westcott TP, Yang Y. DNA supercoiling, localized bending and thermal fluctuations. Trends in Biochemical Sciences. 21: 50. PMID 8851658 DOI: 10.1016/S0968-0004(96)80178-2  0.337
1996 Chirico G, Langowski J. Brownian dynamics simulations of supercoiled DNA with bent sequences. Biophysical Journal. 71: 955-71. PMID 8842235 DOI: 10.1016/S0006-3495(96)79299-8  0.4
1996 Pfannschmidt C, Schaper A, Heim G, Jovin TM, Langowski J. Sequence-specific labeling of superhelical DNA by triple helix formation and psoralen crosslinking Nucleic Acids Research. 24: 1702-1709. PMID 8649989 DOI: 10.1093/nar/24.9.1702  0.402
1995 Rippe K, von Hippel PH, Langowski J. Action at a distance: DNA-looping and initiation of transcription. Trends in Biochemical Sciences. 20: 500-6. PMID 8571451 DOI: 10.1016/S0968-0004(00)89117-3  0.374
1995 Klenin KV, Frank-Kamenetskii MD, Langowski J. Modulation of intramolecular interactions in superhelical DNA by curved sequences: a Monte Carlo simulation study. Biophysical Journal. 68: 81-8. PMID 7711271 DOI: 10.1016/S0006-3495(95)80161-X  0.408
1995 Diekmann S, Langowski J. Supercoiling couples DNA curvature to the overall shape and the internal motion of the DNA molecule in solution Journal of Molecular Structure: Theochem. 336: 227-234. DOI: 10.1016/0166-1280(94)04085-7  0.365
1993 Kremer W, Klenin K, Diekmann S, Langowski J. DNA curvature influences the internal motions of supercoiled DNA. The Embo Journal. 12: 4407-12. PMID 8223450  0.415
1992 Kapp U, Langowski J. Preparation of DNA topoisomers by RP-18 high-performance liquid chromatography Analytical Biochemistry. 206: 293-299. PMID 1443600 DOI: 10.1016/0003-2697(92)90369-I  0.349
1990 Krueger S, Zaccai G, Wlodawer A, Langowski J, O'Dea M, Maxwell A, Gellert M. Neutron and light-scattering studies of DNA gyrase and its complex with DNA. Journal of Molecular Biology. 211: 211-20. PMID 2153834 DOI: 10.1016/0022-2836(90)90021-D  0.395
1989 Langowski J, Giesen U. Configurational and dynamic properties of different length superhelical DNAs measured by dynamic light scattering Biophysical Chemistry. 34: 9-18. PMID 2611344 DOI: 10.1016/0301-4622(89)80036-5  0.352
1987 Langowski J. Salt effects on internal motions of superhelical and linear pUC8 DNA. Dynamic light scattering studies. Biophysical Chemistry. 27: 263-71. PMID 3663849 DOI: 10.1016/0301-4622(87)80066-2  0.426
1986 Langowski J, Giesen U, Lehmann C. Dynamics of superhelical DNA studied by photon correlation spectroscopy. Biophysical Chemistry. 25: 191-200. PMID 3028521 DOI: 10.1016/0301-4622(86)87010-7  0.35
1985 Langowski J, Fujimoto BS, Wemmer DE, Benight AS, Drobny G, Shibata JH, Schurr JM. Deformational dynamics and NMR relaxation of supercoiled DNAs. Biopolymers. 24: 1023-56. PMID 4027335 DOI: 10.1002/Bip.360240609  0.636
1985 Langowski J, Benight AS, Fujimoto BS, Schurr JM, Schomburg U. Change of conformation and internal dynamics of supercoiled DNA upon binding of Escherichia coli single-strand binding protein. Biochemistry. 24: 4022-8. PMID 2996588  0.76
1984 Alves J, Pingoud A, Haupt W, Langowski J, Peters F, Maass G, Wolff C. The influence of sequences adjacent to the recognition site on the cleavage of oligodeoxynucleotides by the EcoRI endonuclease. European Journal of Biochemistry / Febs. 140: 83-92. PMID 6323183  0.517
1983 Langowski J, Alves J, Pingoud A, Maass G. Does the specific recognition of DNA by the restriction endonuclease EcoRI involve a linear diffusion step? Investigation of the processivity of the EcoRI endonuclease. Nucleic Acids Research. 11: 501-13. PMID 6298727 DOI: 10.1093/nar/11.2.501  0.604
1982 Alves J, Pingoud A, Langowski J, Urbanke C, Maass G. Two identical subunits of the EcoRI restriction endonuclease Co-operate in the binding and cleavage of the palindromic substrate. European Journal of Biochemistry / Febs. 124: 139-42. PMID 6282584  0.523
1981 Goppelt M, Langowski J, Pingoud A, Haupt W, Urbanke C, Mayer H, Maass G. The effect of several nucleic acid binding drugs on the cleavage of d(GGAATTCC) and pBR 322 by the Eco RI restriction endonuclease. Nucleic Acids Research. 9: 6115-27. PMID 6273824 DOI: 10.1093/nar/9.22.6115  0.55
1981 Shore D, Langowski J, Baldwin RL. DNA flexibility studied by covalent closure of short fragments into circles. Proceedings of the National Academy of Sciences of the United States of America. 78: 4833-7. PMID 6272277 DOI: 10.1073/Pnas.78.8.4833  0.419
1981 Langowski J, Urbanke C, Pingoud A, Maass G. Transient cleavage kinetics of the Eco RI restriction endonuclease measured in a pulsed quench-flow apparatus: enzyme concentration-dependent activity change. Nucleic Acids Research. 9: 3483-90. PMID 6269084 DOI: 10.1093/nar/9.14.3483  0.578
1981 Alves J, Pingoud A, Langowski J, Maass G, Baltzinger M, Holler E. The endonucleolytic reaction catalysed by the EcoRI restriction enzyme is inhibited when the enzyme is in excess over substrate Biophysics of Structure and Mechanism. 7: 247-248. DOI: 10.1007/BF02425379  0.45
1980 Langowski J, Pingoud A, Goppelt M, Maass G. Inhibition of Eco RI action by polynucleotides. A characterization of the non-specific binding of the enzyme to DNA. Nucleic Acids Research. 8: 4727-36. PMID 6255431 DOI: 10.1093/nar/8.20.4727  0.602
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