141 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Huang J, Lou Y, Liu J, Bulet P, Cai C, Ma K, Jiao R, Hoffmann JA, Liégeois S, Li Z, Ferrandon D. A Toll pathway effector protects specifically from distinct toxins secreted by a fungus or a bacterium. Proceedings of the National Academy of Sciences of the United States of America. 120: e2205140120. PMID 36917667 DOI: 10.1073/pnas.2205140120  0.387
2018 Goto A, Okado K, Martins N, Cai H, Barbier V, Lamiable O, Troxler L, Santiago E, Kuhn L, Paik D, Silverman N, Holleufer A, Hartmann R, Liu J, Peng T, ... Hoffmann JA, et al. The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila. Immunity. PMID 30119996 DOI: 10.1016/J.Immuni.2018.07.013  0.405
2016 Lamiable O, Arnold J, da Silva de Faria IJ, Proveti Olmo R, Bergami F, Meignin C, Hoffmann JA, Marques JT, Imler JL. Analysis of the contribution of hemocytes and autophagy to Drosophila antiviral immunity. Journal of Virology. PMID 27009948 DOI: 10.1128/Jvi.00238-16  0.335
2016 Lamiable O, Kellenberger C, Kemp C, Troxler L, Pelte N, Boutros M, Marques JT, Daeffler L, Hoffmann JA, Roussel A, Imler JL. Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. PMID 26739560 DOI: 10.1073/Pnas.1516122113  0.406
2014 Majzoub K, Hafirassou ML, Meignin C, Goto A, Marzi S, Fedorova A, Verdier Y, Vinh J, Hoffmann JA, Martin F, Baumert TF, Schuster C, Imler JL. RACK1 controls IRES-mediated translation of viruses. Cell. 159: 1086-95. PMID 25416947 DOI: 10.1016/J.Cell.2014.10.041  0.321
2014 Chtarbanova S, Lamiable O, Lee KZ, Galiana D, Troxler L, Meignin C, Hetru C, Hoffmann JA, Daeffler L, Imler JL. Drosophila C virus systemic infection leads to intestinal obstruction. Journal of Virology. 88: 14057-69. PMID 25253354 DOI: 10.1128/Jvi.02320-14  0.316
2014 Tartey S, Matsushita K, Vandenbon A, Ori D, Imamura T, Mino T, Standley DM, Hoffmann JA, Reichhart JM, Akira S, Takeuchi O. Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex. The Embo Journal. 33: 2332-48. PMID 25107474 DOI: 10.15252/Embj.201488447  0.351
2014 Goto A, Fukuyama H, Imler JL, Hoffmann JA. The chromatin regulator DMAP1 modulates activity of the nuclear factor κB (NF-κB) transcription factor Relish in the Drosophila innate immune response Journal of Biological Chemistry. 289: 20470-20476. PMID 24947515 DOI: 10.1074/Jbc.C114.553719  0.411
2013 Fukuyama H, Verdier Y, Guan Y, Makino-Okamura C, Shilova V, Liu X, Maksoud E, Matsubayashi J, Haddad I, Spirohn K, Ono K, Hetru C, Rossier J, Ideker T, Boutros M, ... ... Hoffmann JA, et al. Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge. Proceedings of the National Academy of Sciences of the United States of America. 110: 10717-22. PMID 23749869 DOI: 10.1073/Pnas.1304380110  0.479
2013 Bonnay F, Cohen-Berros E, Hoffmann M, Kim SY, Boulianne GL, Hoffmann JA, Matt N, Reichhart JM. big bang gene modulates gut immune tolerance in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 110: 2957-62. PMID 23378635 DOI: 10.1073/Pnas.1221910110  0.426
2013 Kemp C, Mueller S, Goto A, Barbier V, Paro S, Bonnay F, Dostert C, Troxler L, Hetru C, Meignin C, Pfeffer S, Hoffmann JA, Imler JL. Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila. Journal of Immunology (Baltimore, Md. : 1950). 190: 650-8. PMID 23255357 DOI: 10.4049/Jimmunol.1102486  0.32
2012 Liu X, Sano T, Guan Y, Nagata S, Hoffmann JA, Fukuyama H. Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif Plos One. 7. PMID 22916150 DOI: 10.1371/Journal.Pone.0042725  0.414
2012 Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. Pillars article: the dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 1996. 86: 973-983. Journal of Immunology (Baltimore, Md. : 1950). 188: 5210-20. PMID 22611248  0.318
2012 Fukuyama H, Ndiaye S, Hoffmann J, Rossier J, Liuu S, Vinh J, Verdier Y. On-bead tryptic proteolysis: an attractive procedure for LC-MS/MS analysis of the Drosophila caspase 8 protein complex during immune response against bacteria. Journal of Proteomics. 75: 4610-9. PMID 22450469 DOI: 10.1016/J.Jprot.2012.03.003  0.337
2009 Hetru C, Hoffmann JA. NF-kappaB in the immune response of Drosophila. Cold Spring Harbor Perspectives in Biology. 1: a000232. PMID 20457557 DOI: 10.1101/Cshperspect.A000232  0.455
2009 Mishima Y, Quintin J, Aimanianda V, Kellenberger C, Coste F, Clavaud C, Hetru C, Hoffmann JA, Latgé JP, Ferrandon D, Roussel A. The N-terminal domain of Drosophila Gram-negative binding protein 3 (GNBP3) defines a novel family of fungal pattern recognition receptors. The Journal of Biological Chemistry. 284: 28687-97. PMID 19692333 DOI: 10.1074/Jbc.M109.034587  0.331
2009 Fraiture M, Baxter RH, Steinert S, Chelliah Y, Frolet C, Quispe-Tintaya W, Hoffmann JA, Blandin SA, Levashina EA. Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium. Cell Host & Microbe. 5: 273-84. PMID 19286136 DOI: 10.1016/J.Chom.2009.01.005  0.33
2008 Deddouche S, Matt N, Budd A, Mueller S, Kemp C, Galiana-Arnoux D, Dostert C, Antoniewski C, Hoffmann JA, Imler JL. The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila. Nature Immunology. 9: 1425-32. PMID 18953338 DOI: 10.1038/Ni.1664  0.353
2008 Maillet F, Bischoff V, Vignal C, Hoffmann J, Royet J. The Drosophila peptidoglycan recognition protein PGRP-LF blocks PGRP-LC and IMD/JNK pathway activation. Cell Host & Microbe. 3: 293-303. PMID 18474356 DOI: 10.1016/J.Chom.2008.04.002  0.776
2008 Goto A, Matsushita K, Gesellchen V, Chamy LE, Kuttenkeuler D, Takeuchi O, Hoffmann JA, Akira S, Boutros M, Reichhart JM. Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice Nature Immunology. 9: 97-104. PMID 18066067 DOI: 10.1038/Ni1543  0.399
2007 Nehme NT, Liégeois S, Kele B, Giammarinaro P, Pradel E, Hoffmann JA, Ewbank JJ, Ferrandon D. A model of bacterial intestinal infections in Drosophila melanogaster. Plos Pathogens. 3: e173. PMID 18039029 DOI: 10.1371/Journal.Ppat.0030173  0.44
2007 Ferrandon D, Imler JL, Hetru C, Hoffmann JA. The Drosophila systemic immune response: Sensing and signalling during bacterial and fungal infections Nature Reviews Immunology. 7: 862-874. PMID 17948019 DOI: 10.1038/Nri2194  0.453
2007 Beutler B, Eidenschenk C, Crozat K, Imler JL, Takeuchi O, Hoffmann JA, Akira S. Genetic analysis of resistance to viral infection Nature Reviews Immunology. 7: 753-766. PMID 17893693 DOI: 10.1038/Nri2174  0.322
2007 Lemaitre B, Hoffmann J. The host defense of Drosophila melanogaster. Annual Review of Immunology. 25: 697-743. PMID 17201680 DOI: 10.1146/Annurev.Immunol.25.022106.141615  0.402
2006 Shiao SH, Whitten MMA, Zachary D, Hoffmann JA, Levashina EA. Fz2 and cdc42 mediate melanization and actin polymerization but are dispensable for Plasmodium killing in the mosquito midgut. Plos Pathogens. 2: e133. PMID 17196037 DOI: 10.1371/Journal.Ppat.0020133  0.335
2006 Gottar M, Gobert V, Matskevich AA, Reichhart JM, Wang C, Butt TM, Belvin M, Hoffmann JA, Ferrandon D. Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors Cell. 127: 1425-1437. PMID 17190605 DOI: 10.1016/J.Cell.2006.10.046  0.437
2006 Frolet C, Thoma M, Blandin S, Hoffmann JA, Levashina EA. Boosting NF-κB-Dependent Basal Immunity of Anopheles gambiae Aborts Development of Plasmodium berghei Immunity. 25: 677-685. PMID 17045818 DOI: 10.1016/J.Immuni.2006.08.019  0.361
2006 Galiana-Arnoux D, Dostert C, Schneemann A, Hoffmann JA, Imler JL. Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila Nature Immunology. 7: 590-597. PMID 16554838 DOI: 10.1038/Ni1335  0.32
2006 Bischoff V, Vignal C, Duvic B, Boneca IG, Hoffmann JA, Royet J. Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2. Plos Pathogens. 2: e14. PMID 16518472 DOI: 10.1371/Journal.Ppat.0020014  0.777
2006 Leclerc V, Pelte N, El Chamy L, Martinelli C, Ligoxygakis P, Hoffmann JA, Reichhart JM. Prophenoloxidase activation is not required for survival to microbial infections in Drosophila. Embo Reports. 7: 231-5. PMID 16322759 DOI: 10.1038/Sj.Embor.7400592  0.386
2005 Kocks C, Cho JH, Nehme N, Ulvila J, Pearson AM, Meister M, Strom C, Conto SL, Hetru C, Stuart LM, Stehle T, Hoffmann JA, Reichhart JM, Ferrandon D, Rämet M, et al. Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Cell. 123: 335-46. PMID 16239149 DOI: 10.1016/J.Cell.2005.08.034  0.444
2005 Dostert C, Jouanguy E, Irving P, Troxler L, Galiana-Arnoux D, Hetru C, Hoffmann JA, Imler JL. The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila Nature Immunology. 6: 946-953. PMID 16086017 DOI: 10.1038/Ni1237  0.413
2005 Irving P, Ubeda JM, Doucet D, Troxler L, Lagueux M, Zachary D, Hoffmann JA, Hetru C, Meister M. New insights into Drosophila larval haemocyte functions through genome-wide analysis. Cellular Microbiology. 7: 335-50. PMID 15679837 DOI: 10.1111/J.1462-5822.2004.00462.X  0.406
2005 Royet J, Reichhart JM, Hoffmann JA. Sensing and signaling during infection in Drosophila Current Opinion in Immunology. 17: 11-17. PMID 15653304 DOI: 10.1016/J.Coi.2004.12.002  0.707
2004 Levy F, Rabel D, Charlet M, Bulet P, Hoffmann JA, Ehret-Sabatier L. Peptidomic and proteomic analyses of the systemic immune response of Drosophila. Biochimie. 86: 607-16. PMID 15556270 DOI: 10.1016/J.Biochi.2004.07.007  0.427
2004 Bischoff V, Vignal C, Boneca IG, Michel T, Hoffmann JA, Royet J. Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria. Nature Immunology. 5: 1175-80. PMID 15448690 DOI: 10.1038/Ni1123  0.761
2004 Imler JL, Ferrandon D, Royet J, Reichhart JM, Hetru C, Hoffmann JA. Toll-dependent and Toll-independent immune responses in Drosophila Journal of Endotoxin Research. 10: 241-246. PMID 15373968 DOI: 10.1177/09680519040100040701  0.717
2004 Ferrandon D, Imler JL, Hoffmann JA. Sensing infection in Drosophila: Toll and beyond Seminars in Immunology. 16: 43-53. PMID 14751763 DOI: 10.1016/J.Smim.2003.10.008  0.424
2003 Gobert V, Gottar M, Matskevich AA, Rutschmann S, Royet J, Belvin M, Hoffmann JA, Ferrandon D. Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors Science. 302: 2126-2130. PMID 14684822 DOI: 10.1126/Science.1085432  0.705
2003 Hoffmann JA. The immune response of Drosophila Nature. 426: 33-38. PMID 14603309 DOI: 10.1038/Nature02021  0.441
2003 Thouzeau C, Le Maho Y, Froget G, Sabatier L, Le Bohec C, Hoffmann JA, Bulet P. Spheniscins, Avian β-Defensins in Preserved Stomach Contents of the King Penguin, Aptenodytes patagonicus Journal of Biological Chemistry. 278: 51053-51058. PMID 14525994 DOI: 10.1074/Jbc.M306839200  0.334
2003 Weber ANR, Tauszig-Delamasure S, Hoffmann JA, Lelièvre E, Gascan H, Ray KP, Morse MA, Imler JL, Gay NJ. Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling Nature Immunology. 4: 794-800. PMID 12872120 DOI: 10.1038/Ni955  0.435
2003 Hetru C, Troxler L, Hoffmann JA. Drosophila melanogaster antimicrobial defense Journal of Infectious Diseases. 187: S327-S334. PMID 12792847 DOI: 10.1086/374758  0.461
2003 Kurz CL, Chauvet S, Andrès E, Aurouze M, Vallet I, Michel GPF, Uh M, Celli J, Filloux A, De Bentzmann S, Steinmetz I, Hoffmann JA, Finlay BB, Gorvel JP, Ferrandon D, et al. Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening Embo Journal. 22: 1451-1460. PMID 12660152 DOI: 10.1093/Emboj/Cdg159  0.37
2003 Imler JL, Hoffmann JA. Toll signaling: The TIReless quest for specificity Nature Immunology. 4: 105-106. PMID 12555093 DOI: 10.1038/Ni0203-105  0.327
2002 Kambris Z, Hoffmann JA, Imler JL, Capovilla M. Tissue and stage-specific expression of the Tolls in Drosophila embryos Gene Expression Patterns. 2: 311-317. PMID 12617819 DOI: 10.1016/S1567-133X(02)00020-0  0.411
2002 Imler JL, Hoffmann JA. Toll receptors in Drosophila: A family of molecules regulating development and immunity Current Topics in Microbiology and Immunology. 270: 63-79. PMID 12467244 DOI: 10.1007/978-3-642-59430-4_4  0.396
2002 Ligoxygakis P, Pelte N, Ji C, Leclerc V, Duvic B, Belvin M, Jiang H, Hoffmann JA, Reichhart JM. A serpin mutant links Toll activation to melanization in the host defence of Drosophila. The Embo Journal. 21: 6330-7. PMID 12456640 DOI: 10.1093/Emboj/Cdf661  0.448
2002 Duvic B, Hoffmann JA, Meister M, Royet J. Notch signaling controls lineage specification during Drosophila larval hematopoiesis. Current Biology : Cb. 12: 1923-7. PMID 12445385 DOI: 10.1016/S0960-9822(02)01297-6  0.654
2002 Naitza S, Rossé C, Kappler C, Georgel P, Belvin M, Gubb D, Camonis J, Hoffmann JA, Reichhart JM. The Drosophila immune defense against gram-negative infection requires the death protein dFADD. Immunity. 17: 575-81. PMID 12433364 DOI: 10.1016/S1074-7613(02)00454-5  0.458
2002 Christophides GK, Zdobnov E, Barillas-Mury C, Birney E, Blandin S, Blass C, Brey PT, Collins FH, Danielli A, Dimopoulos G, Hetru C, Hoa NT, Hoffmann JA, Kanzok SM, Letunic I, et al. Immunity-related genes and gene families in Anopheles gambiae. Science (New York, N.Y.). 298: 159-65. PMID 12364793 DOI: 10.1126/Science.1077136  0.394
2002 Ligoxygakis P, Pelte N, Hoffmann JA, Reichhart JM. Activation of Drosophila Toll during fungal infection by a blood serine protease. Science (New York, N.Y.). 297: 114-6. PMID 12098703 DOI: 10.1126/Science.1072391  0.434
2002 Gottar M, Gobert V, Michel T, Belvin M, Duyk G, Hoffmann JA, Ferrandon D, Royet J. The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein Nature. 416: 640-644. PMID 11912488 DOI: 10.1038/Nature734  0.723
2002 Hoffmann JA, Reichhart JM. Drosophila innate immunity: An evolutionary perspective Nature Immunology. 3: 121-126. PMID 11812988 DOI: 10.1038/Ni0202-121  0.475
2002 Tauszig-Delamasure S, Bilak H, Capovilla M, Hoffmann JA, Imler JL. Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections Nature Immunology. 3: 91-97. PMID 11743586 DOI: 10.1038/Ni747  0.395
2001 Michel T, Relchhart J, Hoffmann JA, Royet J. Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein Nature. 414: 756-759. PMID 11742401 DOI: 10.1038/414756A  0.724
2001 Irving P, Troxler L, Heuer TS, Belvin M, Kopczynski C, Reichhart JM, Hoffmann JA, Hetru C. A genome-wide analysis of immune responses in Drosophila Proceedings of the National Academy of Sciences of the United States of America. 98: 15119-15124. PMID 11742098 DOI: 10.1073/Pnas.261573998  0.378
2001 Georgel P, Naitza S, Kappler C, Ferrandon D, Zachary D, Swimmer C, Kopczynski C, Duyk G, Reichhart JM, Hoffmann JA. Drosophila Immune Deficiency (IMD) Is a Death Domain Protein that Activates Antibacterial Defense and Can Promote Apoptosis Developmental Cell. 1: 503-514. PMID 11703941 DOI: 10.1016/S1534-5807(01)00059-4  0.387
2001 Vizioli J, Bulet P, Hoffmann JA, Kafatos FC, Müller HM, Dimopoulos G. Gambicin: a novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae. Proceedings of the National Academy of Sciences of the United States of America. 98: 12630-5. PMID 11606751 DOI: 10.1073/Pnas.221466798  0.404
2001 Imler JL, Hoffmann JA. Toll receptors in innate immunity Trends in Cell Biology. 11: 304-311. PMID 11413042 DOI: 10.1016/S0962-8924(01)02004-9  0.433
2001 Jung AC, Criqui MC, Rutschmann S, Hoffmann JA, Ferrandon D. Microfluorometer assay to measure the expression of β-galactosidase and green fluorescent protein reporter genes in single Drosophila flies Biotechniques. 30: 594-601. PMID 11252795 DOI: 10.2144/01303Rr04  0.343
2001 Lamberty M, Zachary D, Lanot R, Bordereau C, Robert A, Hoffmann JA, Bulet P. Insect immunity. Constitutive expression of a cysteine-rich antifungal and a linear antibacterial peptide in a termite insect Journal of Biological Chemistry. 276: 4085-4092. PMID 11053427 DOI: 10.1074/Jbc.M002998200  0.355
2001 Alan R, Ezekowitz B, Hoffmann J. Innate immunity still blossoming Current Opinion in Immunology. 13: 53-54. DOI: 10.1016/S0952-7915(00)00181-3  0.346
2000 Imler JL, Tauszig S, Jouanguy E, Forestier C, Hoffmann JA. LPS-induced immune response in Drosophila Journal of Endotoxin Research. 6: 459-462. PMID 11521071 DOI: 10.1177/09680519000060060801  0.442
2000 Imler JL, Hoffmann JA. Toll and Toll-like proteins: An ancient family of receptors signaling infection Reviews in Immunogenetics. 2: 294-304. PMID 11256741  0.319
2000 Tzou P, Ohresser S, Ferrandon D, Capovilla M, Reichhart JM, Lemaitre B, Hoffmann JA, Imler JL. Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity. 13: 737-48. PMID 11114385 DOI: 10.1016/S1074-7613(00)00072-8  0.417
2000 Lagueux M, Perrodou E, Levashina EA, Capovilla M, Hoffmann JA. Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants of Drosophila Proceedings of the National Academy of Sciences of the United States of America. 97: 11427-11432. PMID 11027343 DOI: 10.1073/Pnas.97.21.11427  0.374
2000 Rutschmann S, Jung AC, Zhou R, Silverman N, Hoffmann JA, Ferrandon D. Role of Drosophila IKKγ in a Toll-independent antibacterial immune response Nature Immunology. 1: 342-347. PMID 11017107 DOI: 10.1038/79801  0.462
2000 Tauszig S, Jouanguy E, Hoffmann JA, Imler JL. Toll-related receptors and the control of antimicrobial peptide expression in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 97: 10520-5. PMID 10973475 DOI: 10.1073/Pnas.180130797  0.415
2000 Rutschmann S, Jung AC, Hetru C, Reichhart JM, Hoffmann JA, Ferrandon D. The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila Immunity. 12: 569-580. PMID 10843389 DOI: 10.1016/S1074-7613(00)80208-3  0.468
2000 Meister M, Hetru C, Hoffmann JA. The antimicrobial host defense of Drosophila. Current Topics in Microbiology and Immunology. 248: 17-36. PMID 10793472 DOI: 10.1007/978-3-642-59674-2_2  0.315
2000 Basset A, Khush RS, Braun A, Gardan L, Boccard F, Hoffmann JA, Lemaitre B. The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response. Proceedings of the National Academy of Sciences of the United States of America. 97: 3376-81. PMID 10725405 DOI: 10.1073/Pnas.070357597  0.459
2000 Imler JL, Hoffmann JA. Signaling mechanisms in the antimicrobial host defense of Drosophila. Current Opinion in Microbiology. 3: 16-22. PMID 10679426 DOI: 10.1016/S1369-5274(99)00045-4  0.449
2000 Vizioli J, Bulet P, Charlet M, Lowenberger C, Blass C, Müller HM, Dimopoulos G, Hoffmann J, Kafatos FC, Richman A. Cloning and analysis of a cecropin gene from the malaria vector mosquito, Anopheles gambiae. Insect Molecular Biology. 9: 75-84. PMID 10672074 DOI: 10.1046/J.1365-2583.2000.00164.X  0.367
2000 Hetru C, Letellier L, Oren Z, Hoffmann JA, Shai Y. Androctonin, a hydrophilic disulphide-bridged non-haemolytic anti-microbial peptide: a plausible mode of action. The Biochemical Journal. 345: 653-64. PMID 10642525 DOI: 10.1042/Bj3450653  0.34
1999 Levashina EA, Langley E, Green C, Gubb D, Ashburner M, Hoffmann JA, Reichhart JM. Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. Science (New York, N.Y.). 285: 1917-9. PMID 10489372 DOI: 10.1126/Science.285.5435.1917  0.46
1999 Manfruelli P, Reichhart JM, Steward R, Hoffmann JA, Lemaitre B. A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF. The Embo Journal. 18: 3380-91. PMID 10369678 DOI: 10.1093/Emboj/18.12.3380  0.402
1999 Hoffmann JA, Kafatos FC, Janeway CA, Ezekowitz RA. Phylogenetic perspectives in innate immunity. Science (New York, N.Y.). 284: 1313-8. PMID 10334979 DOI: 10.1126/Science.284.5418.1313  0.408
1999 Lamberty M, Ades S, Uttenweiler-Joseph S, Brookhart G, Bushey D, Hoffmann JA, Bulet P. Insect immunity. Isolation from the lepidopteran Heliothis virescens of a novel insect defensin with potent antifungal activity. The Journal of Biological Chemistry. 274: 9320-6. PMID 10092609 DOI: 10.1074/Jbc.274.14.9320  0.408
1999 Lowenberger CA, Smartt CT, Bulet P, Ferdig MT, Severson DW, Hoffmann JA, Christensen BM. Insect immunity: molecular cloning, expression, and characterization of cDNAs and genomic DNA encoding three isoforms of insect defensin in Aedes aegypti. Insect Molecular Biology. 8: 107-18. PMID 9927179 DOI: 10.1046/J.1365-2583.1999.810107.X  0.321
1999 Lowenberger CA, Kamal S, Chiles J, Paskewitz S, Bulet P, Hoffmann JA, Christensen BM. Mosquito-Plasmodium interactions in response to immune activation of the vector. Experimental Parasitology. 91: 59-69. PMID 9920043 DOI: 10.1006/Expr.1999.4350  0.419
1998 Dimarcq JL, Bulet P, Hetru C, Hoffmann J. Cysteine-rich antimicrobial peptides in invertebrates Biopolymers - Peptide Science Section. 47: 465-477. PMID 10333738 DOI: 10.1002/(Sici)1097-0282(1998)47:6<465::Aid-Bip5>3.0.Co;2-#  0.386
1998 Braun A, Hoffmann JA, Meister M. Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes. Proceedings of the National Academy of Sciences of the United States of America. 95: 14337-42. PMID 9826701 DOI: 10.1073/Pnas.95.24.14337  0.397
1998 Uttenweiler-Joseph S, Moniatte M, Lagueux M, Van Dorsselaer A, Hoffmann JA, Bulet P. Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study. Proceedings of the National Academy of Sciences of the United States of America. 95: 11342-7. PMID 9736738 DOI: 10.1073/Pnas.95.19.11342  0.367
1998 Taguchi S, Bulet P, Hoffmann JA. A novel insect defensin from the ant Formica rufa. Biochimie. 80: 343-6. PMID 9672756 DOI: 10.1016/S0300-9084(98)80078-3  0.318
1998 Shahabuddin M, Fields I, Bulet P, Hoffmann JA, Miller LH. Plasmodium gallinaceum: differential killing of some mosquito stages of the parasite by insect defensin. Experimental Parasitology. 89: 103-12. PMID 9603495 DOI: 10.1006/Expr.1998.4212  0.332
1998 Nicolas E, Reichhart JM, Hoffmann JA, Lemaitre B. In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila. The Journal of Biological Chemistry. 273: 10463-9. PMID 9553105 DOI: 10.1074/Jbc.273.17.10463  0.417
1998 Ferrandon D, Jung AC, Criqui M, Lemaitre B, Uttenweiler-Joseph S, Michaut L, Reichhart J, Hoffmann JA. A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway. The Embo Journal. 17: 1217-27. PMID 9482719 DOI: 10.1093/Emboj/17.5.1217  0.436
1998 Alan R, Ezekowitz B, Hoffmann J. Innate immunity : The blossoming of innate immunity Current Opinion in Immunology. 10: 9-11. DOI: 10.1016/S0952-7915(98)80023-X  0.346
1997 Dimarcq JL, Imler JL, Lanot R, Ezekowitz RA, Hoffmann JA, Janeway CA, Lagueux M. Treatment of l(2)mbn Drosophila tumorous blood cells with the steroid hormone ecdysone amplifies the inducibility of antimicrobial peptide gene expression. Insect Biochemistry and Molecular Biology. 27: 877-86. PMID 9474784 DOI: 10.1016/S0965-1748(97)00072-6  0.391
1997 Lemaitre B, Reichhart JM, Hoffmann JA. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proceedings of the National Academy of Sciences of the United States of America. 94: 14614-9. PMID 9405661 DOI: 10.1073/Pnas.94.26.14614  0.414
1997 Meister M, Lemaitre B, Hoffmann JA. Antimicrobial peptide defense in Drosophila. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 19: 1019-26. PMID 9394624 DOI: 10.1002/Bies.950191112  0.409
1997 Hoffmann JA. Immune responsiveness in vector insects Proceedings of the National Academy of Sciences of the United States of America. 94: 11152-11153. PMID 9326575 DOI: 10.1073/Pnas.94.21.11152  0.425
1996 Ehret-Sabatier L, Loew D, Goyffon M, Fehlbaum P, Hoffmann JA, Van Dorsselaer A, Bulet P. Characterization of novel cysteine-rich antimicrobial peptides from scorpion blood Journal of Biological Chemistry. 271: 29537-29544. PMID 8939880 DOI: 10.1074/Jbc.271.47.29537  0.338
1996 Barillas-Mury C, Charlesworth A, Gross I, Richman A, Hoffmann JA, Kafatos FC. Immune factor Gambif1, a new rel family member from the human malaria vector, Anopheles gambiae. The Embo Journal. 15: 4691-701. PMID 8887560 DOI: 10.1002/J.1460-2075.1996.Tb00846.X  0.417
1996 Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 86: 973-83. PMID 8808632 DOI: 10.1016/S0092-8674(00)80172-5  0.433
1996 Richman AM, Bulet P, Hetru C, Barillas-Mury C, Hoffmann JA, Kafalos FC. Inducible immune factors of the vector mosquito Anopheles gambiae: biochemical purification of a defensin antibacterial peptide and molecular cloning of preprodefensin cDNA. Insect Molecular Biology. 5: 203-10. PMID 8799739 DOI: 10.1111/J.1365-2583.1996.Tb00055.X  0.422
1996 Hoffmann JA, Reichhart JM, Hetru C. Innate immunity in higher insects Current Opinion in Immunology. 8: 8-13. PMID 8729440 DOI: 10.1016/S0952-7915(96)80098-7  0.443
1996 Charlet M, Chernysh S, Philippe H, Hetru C, Hoffmann JA, Bulet P. Innate immunity: Isolation of several cysteine-rich antimicrobial peptides from the blood of a mollusc, Mytilus edulis Journal of Biological Chemistry. 271: 21808-21813. PMID 8702979 DOI: 10.1074/Jbc.271.36.21808  0.36
1996 Lowenberger CA, Ferdig MT, Bulet P, Khalili S, Hoffmann JA, Christensen BM. Aedes aegypti: induced antibacterial proteins reduce the establishment and development of Brugia malayi. Experimental Parasitology. 83: 191-201. PMID 8682188 DOI: 10.1006/Expr.1996.0066  0.439
1996 Franc NC, Dimarcq JL, Lagueux M, Hoffmann J, Ezekowitz RA. Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells. Immunity. 4: 431-43. PMID 8630729 DOI: 10.1016/S1074-7613(00)80410-0  0.309
1996 Gross I, Georgel P, Kappler C, Reichhart JM, Hoffmann JA. Drosophila immunity: A comparative analysis of the Rel proteins dorsal and Dif in the induction of the genes encoding diptericin and cecropin Nucleic Acids Research. 24: 1238-1245. PMID 8614625 DOI: 10.1093/Nar/24.7.1238  0.371
1996 Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA. Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides Proceedings of the National Academy of Sciences of the United States of America. 93: 1221-1225. PMID 8577744 DOI: 10.1073/Pnas.93.3.1221  0.357
1995 Lemaitre B, Meister M, Govind S, Georgel P, Steward R, Reichhart JM, Hoffmann JA. Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila. The Embo Journal. 14: 536-45. PMID 7859742 DOI: 10.1002/J.1460-2075.1995.Tb07029.X  0.412
1995 Bulet P, Hegy G, Lambert J, Van Dorsselaer A, Hoffmann JA, Hetru C. Insect immunity. The inducible antibacterial peptide diptericin carries two O-glycans necessary for biological activity Biochemistry. 34: 7394-7400. PMID 7779781 DOI: 10.1021/Bi00022A012  0.322
1995 Hoffmann JA. Innate immunity of insects Current Opinion in Immunology. 7: 4-10. PMID 7772280 DOI: 10.1016/0952-7915(95)80022-0  0.439
1995 Cornet B, Bonmatin JM, Hetru C, Hoffmann JA, Ptak M, Vovelle F. Refined three-dimensional solution structure of insect defensin A Structure. 3: 435-448. PMID 7663941 DOI: 10.1016/S0969-2126(01)00177-0  0.345
1995 Lowenberger C, Bulet P, Charlet M, Hetru C, Hodgeman B, Christensen BM, Hoffmann JA. Insect immunity: isolation of three novel inducible antibacterial defensins from the vector mosquito, Aedes aegypti. Insect Biochemistry and Molecular Biology. 25: 867-73. PMID 7633471 DOI: 10.1016/0965-1748(95)00043-U  0.37
1995 Lemaitre B, Kromer-Metzger E, Michaut L, Nicolas E, Meister M, Georgel P, Reichhart JM, Hoffmann JA. A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense. Proceedings of the National Academy of Sciences of the United States of America. 92: 9465-9. PMID 7568155 DOI: 10.1073/Pnas.92.21.9465  0.4
1995 Georgel P, Kappler C, Langley E, Gross I, Nicolas E, Reichhart Jm, Hoffmann JA. Drosophila immunity. A sequence homologous to mammalian interferon consensus response element enhances the activity of the diptericin promoter Nucleic Acids Research. 23: 1140-1145. PMID 7537872 DOI: 10.1093/Nar/23.7.1140  0.393
1994 Dimarcq JL, Hoffmann D, Meister M, Bulet P, Lanot R, Reichhart JM, Hoffmann JA. Characterization and transcriptional profiles of a Drosophila gene encoding an insect defensin. A study in insect immunity. European Journal of Biochemistry / Febs. 221: 201-9. PMID 8168509 DOI: 10.1111/J.1432-1033.1994.Tb18730.X  0.364
1994 Cociancich S, Dupont A, Hegy G, Lanot R, Holder F, Hetru C, Hoffmann JA, Bulet P. Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus Biochemical Journal. 300: 567-575. PMID 8002963 DOI: 10.1042/Bj3000567  0.352
1994 Meister M, Braun A, Kappler C, Reichhart JM, Hoffmann JA. Insect immunity. A transgenic analysis in Drosophila defines several functional domains in the diptericin promoter. The Embo Journal. 13: 5958-66. PMID 7813433 DOI: 10.1002/J.1460-2075.1994.Tb06941.X  0.336
1994 Cociancich S, Bulet P, Hetru C, Hoffmann JA. The inducible antibacterial peptides of insects Parasitology Today. 10: 132-139. DOI: 10.1016/0169-4758(94)90260-7  0.328
1993 Hoffmann JA, Hetru C, Reichhart JM. The humoral antibacterial response of Drosophila Febs Letters. 325: 63-66. PMID 8513894 DOI: 10.1016/0014-5793(93)81414-U  0.399
1993 Kappler C, Meister M, Lagueux M, Gateff E, Hoffmann JA, Reichhart JM. Insect immunity. Two 17 bp repeats nesting a kappa B-related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria-challenged Drosophila. The Embo Journal. 12: 1561-8. PMID 8467806 DOI: 10.1002/J.1460-2075.1993.Tb05800.X  0.35
1993 Cociancich S, Goyffon M, Bontems F, Bulet P, Bouet F, Menez A, Hoffmann J. Purification and Characterization of a Scorpion Defensin, a 4kDa Antibacterial Peptide Presenting Structural Similarities with Insect Defensins and Scorpion Toxins Biochemical and Biophysical Research Communications. 194: 17-22. PMID 8333834 DOI: 10.1006/Bbrc.1993.1778  0.328
1993 Reichhart JM, Georgel P, Meister M, Lemaitre B, Kappler C, Hoffmann JA. Expression and nuclear translocation of the rel/NF-kappa B-related morphogen dorsal during the immune response of Drosophila. Comptes Rendus De L'Acadã©Mie Des Sciences. Sã©Rie Iii, Sciences De La Vie. 316: 1218-24. PMID 8062131  0.301
1993 Georgel P, Meister M, Kappler C, Lemaitre B, Reichhart JM, Hoffmann JA. Insect immunity: the diptericin promoter contains multiple functional regulatory sequences homologous to mammalian acute-phase response elements. Biochemical and Biophysical Research Communications. 197: 508-17. PMID 7505569 DOI: 10.1006/Bbrc.1993.2508  0.372
1992 Bulet P, Cociancich S, Reuland M, Sauber F, Bischoff R, Hegy G, Van Dorsselaer A, Hetru C, Hoffmann JA. A novel insect defensin mediates the inducible antibacterial activity in larvae of the dragonfly Aeschna cyanea (Paleoptera, Odonata) European Journal of Biochemistry. 209: 977-984. PMID 1425705 DOI: 10.1111/J.1432-1033.1992.Tb17371.X  0.382
1992 Hoffmann JA, Hetru C. Insect defensins: inducible antibacterial peptides Immunology Today. 13: 411-415. PMID 1418378 DOI: 10.1016/0167-5699(92)90092-L  0.391
1992 Reichhart JM, Meister M, Dimarcq JL, Zachary D, Hoffmann D, Ruiz C, Richards G, Hoffmann JA. Insect immunity: developmental and inducible activity of the Drosophila diptericin promoter. The Embo Journal. 11: 1469-77. PMID 1373375 DOI: 10.1002/J.1460-2075.1992.Tb05191.X  0.364
1992 Reichhart J, Petit I, Legrain M, Dimarcq J, Keppi E, Lecocq J, Hoffmann JA, Achstetter T. Expression and secretion in yeast of active insect defensin, an inducible antibacterial peptide from the fleshfly Phormia terranovae Invertebrate Reproduction & Development. 21: 15-24. DOI: 10.1080/07924259.1992.9672215  0.322
1990 Dimarcq JL, Zachary D, Hoffmann JA, Hoffmann D, Reichhart JM. Insect immunity: Expression of the two major inducible antibacterial peptides, defensin diptericin, in phormia terranovae Embo Journal. 9: 2507-2515. PMID 2369900 DOI: 10.1002/J.1460-2075.1990.Tb07430.X  0.394
1990 Hietter H, Dorsselaer AV, Green B, Denoroy L, Hoffmann J, Luu B. Isolation and structure elucidation of a novel 5-kDa peptide from neurohaemal lobes of the corpora cardiaca of Locusta migratoria (Insecta, Orthoptera). Febs Journal. 187: 241-247. PMID 2298206 DOI: 10.1111/J.1432-1033.1990.Tb15301.X  0.323
1990 Wicker C, Reichhart JM, Hoffmann D, Hultmark D, Samakovlis C, Hoffmann JA. Insect immunity. Characterization of a Drosophila cDNA encoding a novel member of the diptericin family of immune peptides. The Journal of Biological Chemistry. 265: 22493-8. PMID 2125051  0.321
1990 Hoffmann D, Hoffmann JA. Cellular and molecular aspects of insect immunity Research in Immunology. 141: 895-896. PMID 2100018 DOI: 10.1016/0923-2494(90)90189-6  0.345
1990 Frédéric D, Christine K, Charles H, Bernard R, Michéle C, Bang L, Hoffmann JA. Synthesis of high specific activity [3H2-1,2]-7-dehydrocholesterol. Conversion to ecdysone in follicle cells of locusta (Insects) Tetrahedron. 46: 5305-5316. DOI: 10.1016/S0040-4020(01)87837-6  0.331
1989 Lambert J, Keppi E, Dimarcq JL, Wicker C, Reichhart JM, Dunbar B, Lepage P, Van Dorsselaer A, Hoffmann J, Fothergill J. Insect immunity: isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides. Proceedings of the National Academy of Sciences of the United States of America. 86: 262-6. PMID 2911573 DOI: 10.1073/Pnas.86.1.262  0.366
1989 Reichhart JM, Essrich M, Dimarcq JL, Hoffmann D, Hoffmann JA, Lagueux M. Insect immunity. Isolation of cDNA clones corresponding to diptericin, an inducible antibacterial peptide from Phormia terranovae (Diptera). Transcriptional profiles during immunization European Journal of Biochemistry. 182: 423-427. PMID 2544427 DOI: 10.1111/J.1432-1033.1989.Tb14848.X  0.377
1989 Keppi E, Pugsley AP, Lambert J, Wicker C, Dimarcq J, Hoffmann JA, Hoffmann D. Mode of action of diptericin A, a bactericidal peptide induced in the hemolymph of Phormia terranovae larvae Archives of Insect Biochemistry and Physiology. 10: 229-239. DOI: 10.1002/Arch.940100306  0.351
1988 Dimarcq JL, Keppi E, Dunbar B, Lambert J, Reichhart JM, Hoffmann D, Rankine SM, Fothergill JE, Hoffmann JA. Insect immunity. Purification and characterization of a family of novel inducible antibacterial proteins from immunized larvae of the dipteran Phormia terranovae and complete amino-acid sequence of the predominant member, diptericin A. European Journal of Biochemistry. 171: 17-22. PMID 3276515 DOI: 10.1111/J.1432-1033.1988.Tb13752.X  0.371
1987 Meister MF, Brandtner HM, Koolman J, Hoffmann JA. Conversion of a Radiolabelled Putative Ecdysone Precursor, 2,22,25-Trideoxyecdysone (5β-Ketodiol) in Larvae and Pupae of Calliphora vicina International Journal of Invertebrate Reproduction and Development. 12: 13-28. DOI: 10.1080/01688170.1987.10510299  0.677
1987 Burger A, Roussel JP, Colobert F, Kappler C, Hetru C, Luu B, Hoffmann JA. In vitro studies on potential selective and irreversible inhibitors of enzymes involved in the biosynthesis of ecdysone Pesticide Biochemistry and Physiology. 29: 197-208. DOI: 10.1016/0048-3575(87)90150-7  0.536
1986 Keppi E, Zachary D, Robertson M, Hoffmann D, Hoffmann JA. Induced antibacterial proteins in the haemolymph of Phormia terranovae (Diptera): Purification and possible origin of one protein Insect Biochemistry. 16: 395-402. DOI: 10.1016/0020-1790(86)90053-3  0.354
1979 Hirn M, Hetru C, Lagueux M, Hoffmann JA. Prothoracic gland activity and blood titres of ecdysone and ecdysterone during the last larval instar of Locusta migratoria L Journal of Insect Physiology. 25: 255-261. DOI: 10.1016/0022-1910(79)90052-0  0.315
1977 Feyereisen R, Hoffmann JA. Regulation of ecdysone hydroxylation in Locusta migratoria: Rôle of the moulting hormone level Journal of Insect Physiology. 23: 1175-1181. DOI: 10.1016/0022-1910(77)90150-0  0.309
1974 Hoffmann JA, Koolman J. Prothoracic glands in the regulation of ecdysone titres and metabolic fate of injected labelled ecdysone in Locusta migratoria Journal of Insect Physiology. 20: 1593-1601. PMID 4853927 DOI: 10.1016/0022-1910(74)90088-2  0.701
1974 Hoffmann JA, Koolman J, Karlson P, Joly P. Molting hormone titer and metabolic fate of injected ecdysone during the fifth larval instar and in adults of Locusta migratoria (Orthoptera) General and Comparative Endocrinology. 22: 90-97. PMID 4814737 DOI: 10.1016/0016-6480(74)90091-4  0.754
1973 Koolman J, Hoffmann JA, Karlson P. Sulphate esters as inactivation products of ecdysone in Locusta migratoria Hoppe Seyler's Z.Physiol.Chem.. 354: 1043-1048. PMID 4609886 DOI: 10.1515/Bchm2.1973.354.2.1043  0.716
1970 Hoffmann JA, Porte A, Joly P. [On the localization of phenol-oxidase activity in coagulocytes of Locusta migratoria L. (Orthoptera)]. Comptes Rendus Hebdomadaires Des SéAnces De L'AcadéMie Des Sciences. SéRie D: Sciences Naturelles. 270: 629-31. PMID 4985478  0.428
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