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Richard K. Tsai, Ph.D.

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
cell biophysics and polymer engineering
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Dennis E. Discher grad student 2009 Penn, Bioeng
 (Functional characterization of the self signal CD47: From macrophage clearance mechanisms to therapeutic development.)

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Publications

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Hayes BH, Tsai RK, Dooling LJ, et al. (2020) Macrophages eat more after disruption of interactions between CD47 and the checkpoint receptor SIRPα. Journal of Cell Science
Sosale NG, Ivanovska II, Tsai RK, et al. (2016) "Marker of Self" CD47 on lentiviral vectors decreases macrophage-mediated clearance and increases delivery to SIRPA-expressing lung carcinoma tumors. Molecular Therapy. Methods & Clinical Development. 3: 16080
Rodriguez PL, Harada T, Christian DA, et al. (2013) Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles. Science (New York, N.Y.). 339: 971-5
Sosale N, Ivanovska II, Tsai RK, et al. (2013) Lentiviral Vectors Nano-Engineered with ‘Marker of Self’ CD47 to avoid Immune Surveillance Biophysical Journal. 104: 417a
Stachelek SJ, Finley MJ, Alferiev IS, et al. (2011) The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation. Biomaterials. 32: 4317-26
Sosale N, Tsai RK, Ivanovska I, et al. (2011) Reducing Immune Response against Lentiviral Vectors: Lentiviral Vector Presentation of CD47, The ‘Marker of Self’ Biophysical Journal. 100: 403a
Tsai RK, Rodriguez PL, Discher DE. (2010) Self inhibition of phagocytosis: the affinity of 'marker of self' CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels. Blood Cells, Molecules & Diseases. 45: 67-74
Discher DE, Rodriguez P, Tsai R, et al. (2010) Physics of Phagocytosis in Self Recognition: Particle Size and Myosin Forces Biophysical Journal. 98: 727a
Tsai R, Rodriguez P, Discher DE. (2008) Cys shotgun labeling of macrophages adhering to and engulfing Ig-opsonized cells. Transfusion Clinique Et Biologique : Journal De La SociéTé FrançAise De Transfusion Sanguine. 15: 58-61
Tsai RK, Discher DE. (2008) Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. The Journal of Cell Biology. 180: 989-1003
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