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Jens Meiler - Publications

Affiliations: 
Vanderbilt University, Nashville, TN 
Website:
http://www.meilerlab.org/
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Year Citation  Score
2024 Woods H, Leman JK, Meiler J. Modeling membrane geometries implicitly in Rosetta. Protein Science : a Publication of the Protein Society. 33: e4908. PMID 38358133 DOI: 10.1002/pro.4908  0.716
2024 Melancon K, Pliushcheuskaya P, Meiler J, Künze G. Targeting ion channels with ultra-large library screening for hit discovery. Frontiers in Molecular Neuroscience. 16: 1336004. PMID 38249296 DOI: 10.3389/fnmol.2023.1336004  0.761
2023 Sekar TV, Elghonaimy EA, Swancutt KL, Diegeler S, Gonzalez I, Hamilton C, Leung PQ, Meiler J, Martina CE, Whitney M, Aguilera TA. Simultaneous selection of nanobodies for accessible epitopes on immune cells in the tumor microenvironment. Nature Communications. 14: 7473. PMID 37978291 DOI: 10.1038/s41467-023-43038-z  0.774
2023 Marin A, Mamun AA, Patel H, Akamatsu H, Ye D, Sudhan DR, Eli L, Marcelain K, Brown BP, Meiler J, Arteaga CL, Hanker AB. Acquired secondary HER2 mutations enhance HER2/MAPK signaling and promote resistance to HER2 kinase inhibition in breast cancer. Cancer Research. PMID 37404061 DOI: 10.1158/0008-5472.CAN-22-3617  0.56
2023 Martina CE, Crowe JE, Meiler J. Glycan masking in vaccine design: Targets, immunogens and applications. Frontiers in Immunology. 14: 1126034. PMID 37033915 DOI: 10.3389/fimmu.2023.1126034  0.763
2023 Ledwitch KV, Künze G, McKinney JR, Okwei E, Larochelle K, Pankewitz L, Ganguly S, Darling HL, Coin I, Meiler J. Sparse pseudocontact shift NMR data obtained from a non-canonical amino acid-linked lanthanide tag improves integral membrane protein structure prediction. Journal of Biomolecular Nmr. PMID 37016190 DOI: 10.1007/s10858-023-00412-9  0.545
2023 Okwei E, Smith ST, Bender BJ, Allison B, Ganguly S, Geanes A, Zhang X, Ledwitch K, Meiler J. Rosetta's Predictive Ability for Low-Affinity Ligand Binding in Fragment-Based Drug Discovery. Biochemistry. PMID 36626571 DOI: 10.1021/acs.biochem.2c00649  0.512
2022 Schoeder CT, Gilchuk P, Sangha AK, Ledwitch KV, Malherbe DC, Zhang X, Binshtein E, Williamson LE, Martina CE, Dong J, Armstrong E, Sutton R, Nargi R, Rodriguez J, Kuzmina N, ... ... Meiler J, et al. Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region. Plos Pathogens. 18: e1010518. PMID 35584193 DOI: 10.1371/journal.ppat.1010518  0.782
2022 Borza CM, Bolas G, Zhang X, Browning Monroe MB, Zhang MZ, Meiler J, Skwark MJ, Harris RC, Lapierre LA, Goldenring JR, Hook M, Rivera J, Brown KL, Leitinger B, Tyska MJ, et al. The Collagen Receptor Discoidin Domain Receptor 1b Enhances Integrin β1-Mediated Cell Migration by Interacting With Talin and Promoting Rac1 Activation. Frontiers in Cell and Developmental Biology. 10: 836797. PMID 35309920 DOI: 10.3389/fcell.2022.836797  0.688
2021 Koehler Leman J, Lyskov S, Lewis SM, Adolf-Bryfogle J, Alford RF, Barlow K, Ben-Aharon Z, Farrell D, Fell J, Hansen WA, Harmalkar A, Jeliazkov J, Kuenze G, Krys JD, Ljubetič A, ... ... Meiler J, et al. Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks. Nature Communications. 12: 6947. PMID 34845212 DOI: 10.1038/s41467-021-27222-7  0.78
2021 Schoeder CT, Schmitz S, Adolf-Bryfogle J, Sevy AM, Finn JA, Sauer MF, Bozhanova NG, Mueller BK, Sangha AK, Bonet J, Sheehan JH, Kuenze G, Marlow B, Smith ST, Woods H, ... ... Meiler J, et al. Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design. Biochemistry. PMID 33705117 DOI: 10.1021/acs.biochem.0c00912  0.785
2020 Gulsevin A, Meiler J. An Investigation of Three-Finger Toxin-nAChR Interactions through Rosetta Protein Docking. Toxins. 12. PMID 32947868 DOI: 10.20944/Preprints202008.0318.V1  0.307
2020 Finn JA, Dong J, Sevy AM, Parrish E, Gilchuk I, Nargi R, Scarlett-Jones M, Reichard W, Bombardi R, Voss TG, Meiler J, Crowe JE. Identification of Structurally Related Antibodies in Antibody Sequence Databases Using Rosetta-Derived Position-Specific Scoring. Structure (London, England : 1993). PMID 32783953 DOI: 10.1016/J.Str.2020.07.012  0.307
2020 Leman JK, Weitzner BD, Lewis SM, Adolf-Bryfogle J, Alam N, Alford RF, Aprahamian M, Baker D, Barlow KA, Barth P, Basanta B, Bender BJ, Blacklock K, Bonet J, Boyken SE, ... ... Meiler J, et al. Macromolecular modeling and design in Rosetta: recent methods and frameworks. Nature Methods. PMID 32483333 DOI: 10.1038/S41592-020-0848-2  0.737
2020 Seacrist CD, Kuenze G, Hoffmann RM, Moeller BE, Burke JE, Meiler J, Blind RD. Integrated Structural Modeling of Full-Length LRH-1 Reveals Inter-domain Interactions Contribute to Receptor Structure and Function. Structure (London, England : 1993). PMID 32433991 DOI: 10.1016/J.Str.2020.04.020  0.308
2020 Koehler Leman J, Weitzner BD, Renfrew PD, Lewis SM, Moretti R, Watkins AM, Mulligan VK, Lyskov S, Adolf-Bryfogle J, Labonte JW, Krys J, Bystroff C, Schief W, Gront D, ... ... Meiler J, et al. Better together: Elements of successful scientific software development in a distributed collaborative community. Plos Computational Biology. 16: e1007507. PMID 32365137 DOI: 10.1371/Journal.Pcbi.1007507  0.774
2020 Sauer MF, Sevy AM, Crowe JE, Meiler J. Multi-state design of flexible proteins predicts sequences optimal for conformational change. Plos Computational Biology. 16: e1007339. PMID 32032348 DOI: 10.1371/Journal.Pcbi.1007339  0.318
2020 Wedemeyer MJ, Mueller BK, Bender BJ, Meiler J, Volkman BF. Comparative modeling and docking of chemokine-receptor interactions with Rosetta. Biochemical and Biophysical Research Communications. PMID 31924303 DOI: 10.1016/J.Bbrc.2019.12.076  0.322
2020 Leman JK, Weitzner BD, Renfrew PD, Lewis SM, Moretti R, Watkins AM, Mulligan VK, Lyskov S, Adolf-Bryfogle J, Labonte JW, Krys J, Bystroff C, Schief W, Gront D, Schueler-Furman O, ... ... Meiler J, et al. Members of the RosettaCommons Consortium. Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.1007507.S009  0.736
2020 Leman JK, Weitzner BD, Renfrew PD, Lewis SM, Moretti R, Watkins AM, Mulligan VK, Lyskov S, Adolf-Bryfogle J, Labonte JW, Krys J, Bystroff C, Schief W, Gront D, Schueler-Furman O, ... ... Meiler J, et al. Details of Remaining Collective Challenges. Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.1007507.S008  0.748
2020 Leman JK, Weitzner BD, Renfrew PD, Lewis SM, Moretti R, Watkins AM, Mulligan VK, Lyskov S, Adolf-Bryfogle J, Labonte JW, Krys J, Bystroff C, Schief W, Gront D, Schueler-Furman O, ... ... Meiler J, et al. Commercial spin-off companies from the Rosetta community. Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.1007507.S007  0.74
2020 Leman JK, Weitzner BD, Renfrew PD, Lewis SM, Moretti R, Watkins AM, Mulligan VK, Lyskov S, Adolf-Bryfogle J, Labonte JW, Krys J, Bystroff C, Schief W, Gront D, Schueler-Furman O, ... ... Meiler J, et al. Values Statement: Equality and Inclusion in the RosettaCommons. Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.1007507.S005  0.727
2020 Leman JK, Weitzner BD, Renfrew PD, Lewis SM, Moretti R, Watkins AM, Mulligan VK, Lyskov S, Adolf-Bryfogle J, Labonte JW, Krys J, Bystroff C, Schief W, Gront D, Schueler-Furman O, ... ... Meiler J, et al. Descriptions of the Rosetta board positions. Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.1007507.S004  0.735
2020 Leman JK, Weitzner BD, Renfrew PD, Lewis SM, Moretti R, Watkins AM, Mulligan VK, Lyskov S, Adolf-Bryfogle J, Labonte JW, Krys J, Bystroff C, Schief W, Gront D, Schueler-Furman O, ... ... Meiler J, et al. Typical development workflow in the Rosetta community. Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.1007507.S003  0.751
2020 Leman JK, Weitzner BD, Renfrew PD, Lewis SM, Moretti R, Watkins AM, Mulligan VK, Lyskov S, Adolf-Bryfogle J, Labonte JW, Krys J, Bystroff C, Schief W, Gront D, Schueler-Furman O, ... ... Meiler J, et al. Specific tests for Rosetta running on our automated testing framework. Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.1007507.S002  0.741
2020 Leman JK, Weitzner BD, Renfrew PD, Lewis SM, Moretti R, Watkins AM, Mulligan VK, Lyskov S, Adolf-Bryfogle J, Labonte JW, Krys J, Bystroff C, Schief W, Gront D, Schueler-Furman O, ... ... Meiler J, et al. Growth in Rosetta PIs and conference attendees. Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.1007507.S001  0.73
2019 Del Alamo D, Tessmer MH, Stein RA, Feix JB, Mchaourab HS, Meiler J. Rapid Simulation of Unprocessed DEER Decay Data for Protein Fold Prediction. Biophysical Journal. PMID 31892409 DOI: 10.1016/J.Bpj.2019.12.011  0.35
2019 Berman HM, Adams PD, Bonvin AA, Burley SK, Carragher B, Chiu W, DiMaio F, Ferrin TE, Gabanyi MJ, Goddard TD, Griffin PR, Haas J, Hanke CA, Hoch JC, Hummer G, ... ... Meiler J, et al. Federating Structural Models and Data: Outcomes from A Workshop on Archiving Integrative Structures. Structure (London, England : 1993). PMID 31780431 DOI: 10.1016/J.Str.2019.11.002  0.323
2019 Kuenze G, Bonneau R, Leman JK, Meiler J. Integrative Protein Modeling in RosettaNMR from Sparse Paramagnetic Restraints. Structure (London, England : 1993). PMID 31522945 DOI: 10.1016/J.Str.2019.08.012  0.792
2019 Kuenze G, Duran AM, Woods H, Brewer KR, McDonald EF, Vanoye CG, George AL, Sanders CR, Meiler J. Upgraded molecular models of the human KCNQ1 potassium channel. Plos One. 14: e0220415. PMID 31518351 DOI: 10.1371/Journal.Pone.0220415  0.319
2019 Li B, Mendenhall J, Meiler J. Interfaces Between Alpha-helical Integral Membrane Proteins: Characterization, Prediction, and Docking. Computational and Structural Biotechnology Journal. 17: 699-711. PMID 31303974 DOI: 10.1016/J.Csbj.2019.05.005  0.351
2019 Kuenze G, Meiler J. Protein structure prediction using sparse NOE and RDC restraints with Rosetta in CASP13. Proteins. PMID 31292988 DOI: 10.1002/Prot.25769  0.372
2019 Xia Y, Ledwitch K, Kuenze G, Duran A, Li J, Sanders CR, Manning C, Meiler J. A unified structural model of the mammalian translocator protein (TSPO). Journal of Biomolecular Nmr. PMID 31243635 DOI: 10.1007/S10858-019-00257-1  0.349
2019 Brown B, Mendenhall JL, Meiler J. BCL::MolAlign: Three-Dimensional Small Molecule Alignment for Pharmacophore Mapping. Journal of Chemical Information and Modeling. PMID 30707580 DOI: 10.1021/Acs.Jcim.9B00020  0.316
2019 Wedemeyer MJ, Mueller BK, Bender BJ, Meiler J, Volkman BF. Modeling the complete chemokine-receptor interaction. Methods in Cell Biology. 149: 289-314. PMID 30616825 DOI: 10.1016/Bs.Mcb.2018.09.005  0.312
2018 Bender BJ, Vortmeier G, Ernicke S, Bosse M, Kaiser A, Els-Heindl S, Krug U, Beck-Sickinger A, Meiler J, Huster D. Structural Model of Ghrelin Bound to its G Protein-Coupled Receptor. Structure (London, England : 1993). PMID 30686667 DOI: 10.1016/J.Str.2018.12.004  0.311
2018 Bhate MP, Lemmin T, Kuenze G, Mensa B, Ganguly S, Peters J, Schmidt N, Pelton JG, Gross C, Meiler J, DeGrado WF. Structure and function of the transmembrane domain of NsaS, an antibiotic sensing histidine kinase in S. aureus. Journal of the American Chemical Society. PMID 29771498 DOI: 10.1021/Jacs.7B09670  0.561
2018 Combs SA, Mueller BK, Meiler J. Holistic Approach to Partial Covalent Interactions in Protein Structure Prediction and Design with Rosetta. Journal of Chemical Information and Modeling. PMID 29641200 DOI: 10.1021/Acs.Jcim.7B00398  0.314
2018 Xia Y, Fischer AW, Teixeira P, Weiner B, Meiler J. Integrated Structural Biology for α-Helical Membrane Protein Structure Determination. Structure (London, England : 1993). PMID 29526436 DOI: 10.1016/J.Str.2018.02.006  0.323
2018 Sivley RM, Dou X, Meiler J, Bush WS, Capra JA. Comprehensive Analysis of Constraint on the Spatial Distribution of Missense Variants in Human Protein Structures. American Journal of Human Genetics. PMID 29455857 DOI: 10.1016/J.Ajhg.2018.01.017  0.301
2018 Sevy AM, Panda S, Crowe JE, Meiler J, Vorobeychik Y. Integrating linear optimization with structural modeling to increase HIV neutralization breadth. Plos Computational Biology. 14: e1005999. PMID 29451898 DOI: 10.1371/Journal.Pcbi.1005999  0.344
2018 Joedicke L, Mao J, Kuenze G, Reinhart C, Kalavacherla T, Jonker HRA, Richter C, Schwalbe H, Meiler J, Preu J, Michel H, Glaubitz C. The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors. Nature Chemical Biology. PMID 29334381 DOI: 10.1038/Nchembio.2551  0.463
2018 Tessmer MH, Anderson DM, Pickrum AM, Riegert MO, Moretti R, Meiler J, Feix JB, Frank DW. Identification of a ubiquitin-binding interface using Rosetta and DEER. Proceedings of the National Academy of Sciences of the United States of America. PMID 29295930 DOI: 10.1073/Pnas.1716861115  0.353
2018 Mao J, Lopez JJ, Shukla AK, Kuenze G, Meiler J, Schwalbe H, Michel H, Glaubitz C. Backbone structure of free bradykinin (BK) in DDM/CHS detergent micelle determined by MAS SSNMR Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr34207  0.422
2018 Mao J, Lopez JJ, Shukla AK, Kuenze G, Meiler J, Schwalbe H, Michel H, Glaubitz C. Backbone structure of bradykinin (BK) peptide bound to human Bradykinin 2 Receptor (B2R) determined by MAS SSNMR Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr34206  0.438
2017 Fu DY, Meiler J. The Predictive Power of Different Types of Experimental Restraints in Small Molecule Docking: A Review. Journal of Chemical Information and Modeling. PMID 29286651 DOI: 10.1021/Acs.Jcim.7B00418  0.304
2017 Duran AM, Meiler J. Computational Design of Membrane Proteins using RosettaMembrane. Protein Science : a Publication of the Protein Society. PMID 29090504 DOI: 10.1002/Pro.3335  0.322
2017 Li B, Fooksa M, Heinze S, Meiler J. Finding the needle in the haystack: towards solving the protein-folding problem computationally. Critical Reviews in Biochemistry and Molecular Biology. 1-28. PMID 28976219 DOI: 10.1080/10409238.2017.1380596  0.327
2017 Moretti R, Lyskov S, Das R, Meiler J, Gray JJ. Web-accessible molecular modeling with Rosetta: The Rosetta Online Server That Includes Everyone (ROSIE). Protein Science : a Publication of the Protein Society. PMID 28960691 DOI: 10.1002/Pro.3313  0.655
2017 Teixeira PL, Mendenhall JL, Heinze S, Weiner B, Skwark MJ, Meiler J. Membrane protein contact and structure prediction using co-evolution in conjunction with machine learning. Plos One. 12: e0177866. PMID 28542325 DOI: 10.1371/Journal.Pone.0177866  0.734
2017 Li B, Mendenhall J, Nguyen ED, Weiner BE, Fischer AW, Meiler J. Improving Prediction of Helix-Helix Packing in Membrane Proteins Using Predicted Contact Numbers as Restraints. Proteins. PMID 28263405 DOI: 10.1002/Prot.25281  0.327
2016 Borza CM, Su Y, Tran TL, Yu L, Steyns N, Temple KJ, Skwark MJ, Meiler J, Lindsley CW, Hicks BR, Leitinger B, Zent R, Pozzi A. Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 27915093 DOI: 10.1016/J.Matbio.2016.11.009  0.698
2016 Beck-Sickinger AG, Burkert K, Zellmann T, Kaiser A, Meier R, Stichel J, Meiler J, Mittapalli GK, Roberts E. Deep Hydrophobic Binding Cavity is the Main Interaction of Different Y2R Antagonists. Chemmedchem. PMID 27874262 DOI: 10.1002/Cmdc.201600433  0.303
2016 Kroncke BM, Van Horn WD, Smith J, Kang C, Welch RC, Song Y, Nannemann DP, Taylor KC, Sisco NJ, George AL, Meiler J, Vanoye CG, Sanders CR. Structural basis for KCNE3 modulation of potassium recycling in epithelia. Science Advances. 2: e1501228. PMID 27626070 DOI: 10.1126/Sciadv.1501228  0.758
2016 Kroncke BM, Duran AM, Mendenhall JL, Meiler J, Blume JD, Sanders CR. Documentation of an Imperative to Improve Methods for Predicting Membrane Protein Stability. Biochemistry. PMID 27564391 DOI: 10.1021/Acs.Biochem.6B00537  0.315
2016 Bender BJ, Cisneros A, Duran AM, Finn JA, Fu D, Lokits AD, Mueller BK, Sangha AK, Sauer MF, Sevy AM, Sliwoski G, Sheehan JH, DiMaio F, Meiler J, Moretti R. Protocols for Molecular Modeling with Rosetta3 and RosettaScripts. Biochemistry. PMID 27490953 DOI: 10.1021/Acs.Biochem.6B00444  0.358
2016 Nnamani MC, Ganguly S, Erkenbrack EM, Lynch VJ, Mizoue LS, Tong Y, Darling HL, Fuxreiter M, Meiler J, Wagner GP. A Derived Allosteric Switch Underlies the Evolution of Conditional Cooperativity between HOXA11 and FOXO1. Cell Reports. PMID 27239043 DOI: 10.1016/J.Celrep.2016.04.088  0.54
2016 Finn JA, Koehler Leman J, Willis JR, Cisneros A, Crowe JE, Meiler J. Improving Loop Modeling of the Antibody Complementarity-Determining Region 3 Using Knowledge-Based Restraints. Plos One. 11: e0154811. PMID 27182833 DOI: 10.1371/Journal.Pone.0154811  0.319
2016 Figueroa M, Sleutel M, Vandevenne M, Parvizi G, Attout S, Jacquin O, Vandenameele J, Fischer AW, Damblon C, Goormaghtigh E, Valerio-Lepiniec M, Urvoas A, Durand D, Pardon E, Steyaert J, ... ... Meiler J, et al. The unexpected structure of the designed protein octarellin V.1 forms a challenge for protein structure prediction tools. Journal of Structural Biology. PMID 27181418 DOI: 10.1016/J.Jsb.2016.05.004  0.36
2016 Fischer AW, Bordignon E, Bleicken S, García-Sáez AJ, Jeschke G, Meiler J. Pushing the size limit of de novo structure ensemble prediction guided by sparse SDSL-EPR restraints to 200 residues: The monomeric and homodimeric forms of BAX. Journal of Structural Biology. PMID 27129417 DOI: 10.1016/J.Jsb.2016.04.014  0.355
2016 Schaarschmidt J, Nagel MB, Huth S, Jaeschke H, Moretti R, Hintze V, von Bergen M, Kalkhof S, Meiler J, Paschke R. Rearrangement of the extracellular domain/extracellular loop 1 interface is critical for thyrotropin receptor activation. The Journal of Biological Chemistry. PMID 27129207 DOI: 10.1074/Jbc.M115.709659  0.324
2016 Moretti R, Bender BJ, Allison B, Meiler J. Rosetta and the Design of Ligand Binding Sites. Methods in Molecular Biology (Clifton, N.J.). 1414: 47-62. PMID 27094285 DOI: 10.1007/978-1-4939-3569-7_4  0.312
2016 Fischer AW, Heinze S, Putnam DK, Li B, Pino JC, Xia Y, Lopez CF, Meiler J. CASP11 - An Evaluation of a Modular BCL::Fold-Based Protein Structure Prediction Pipeline. Plos One. 11: e0152517. PMID 27046050 DOI: 10.1371/Journal.Pone.0152517  0.357
2016 Li B, Mendenhall J, Nguyen DE, Weiner BE, Fischer AW, Meiler J. Accurate Prediction of Contact Numbers for Multi-Spanning Helical Membrane Proteins. Journal of Chemical Information and Modeling. PMID 26804342 DOI: 10.1021/Acs.Jcim.5B00517  0.318
2015 Kothiwale S, Mendenhall JL, Meiler J. BCL::Conf: small molecule conformational sampling using a knowledge based rotamer library. Journal of Cheminformatics. 7: 47. PMID 26473018 DOI: 10.1186/S13321-015-0095-1  0.308
2015 DeLuca S, Khar K, Meiler J. Fully Flexible Docking of Medium Sized Ligand Libraries with RosettaLigand. Plos One. 10: e0132508. PMID 26207742 DOI: 10.1371/Journal.Pone.0132508  0.316
2015 Sevy AM, Jacobs TM, Crowe JE, Meiler J. Design of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences. Plos Computational Biology. 11: e1004300. PMID 26147100 DOI: 10.1371/Journal.Pcbi.1004300  0.329
2015 Putnam DK, Weiner BE, Woetzel N, Lowe EW, Meiler J. BCL::SAXS: GPU accelerated debye method for computation of small angle X Ray scattering profiles. Proteins. PMID 26018949 DOI: 10.1002/Prot.24838  0.329
2015 Hofmann T, Fischer AW, Meiler J, Kalkhof S. Protein structure prediction guided by crosslinking restraints - A systematic evaluation of the impact of the crosslinking spacer length. Methods (San Diego, Calif.). PMID 25986934 DOI: 10.1016/J.Ymeth.2015.05.014  0.329
2015 Kaiser A, Müller P, Zellmann T, Scheidt HA, Thomas L, Bosse M, Meier R, Meiler J, Huster D, Beck-Sickinger AG, Schmidt P. Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y2 Receptor Binding and Activation. Angewandte Chemie (International Ed. in English). 54: 7446-9. PMID 25924821 DOI: 10.1002/Anie.201411688  0.307
2015 Fischer AW, Alexander NS, Woetzel N, Karakas M, Weiner BE, Meiler J. BCL::MP-Fold: Membrane protein structure prediction guided by EPR restraints. Proteins. PMID 25820805 DOI: 10.1002/Prot.24801  0.314
2015 Heinze S, Putnam DK, Fischer AW, Kohlmann T, Weiner BE, Meiler J. CASP10-BCL::Fold efficiently samples topologies of large proteins. Proteins. 83: 547-63. PMID 25581562 DOI: 10.1002/Prot.24733  0.333
2014 Sevy AM, Meiler J. Antibodies: Computer-Aided Prediction of Structure and Design of Function. Microbiology Spectrum. 2. PMID 26104439 DOI: 10.1128/Microbiolspec.Aid-0024-2014  0.317
2014 Lössl P, Kölbel K, Tänzler D, Nannemann D, Ihling CH, Keller MV, Schneider M, Zaucke F, Meiler J, Sinz A. Analysis of nidogen-1/laminin γ1 interaction by cross-linking, mass spectrometry, and computational modeling reveals multiple binding modes. Plos One. 9: e112886. PMID 25387007 DOI: 10.1371/Journal.Pone.0112886  0.755
2014 Margeti? A, Nannemann D, Meiler J, Huster D, Theisgen S. Guanylate Cyclase-Activating Protein-2 Undergoes Structural Changes upon Binding to Detergent Micelles and Bicelles. Biochimica Et Biophysica Acta. 1838: 2767-77. PMID 25051529 DOI: 10.1016/J.Bbamem.2014.07.012  0.767
2014 Doberenz C, Zorn M, Falke D, Nannemann D, Hunger D, Beyer L, Ihling CH, Meiler J, Sinz A, Sawers RG. Pyruvate formate-lyase interacts directly with the formate channel FocA to regulate formate translocation. Journal of Molecular Biology. 426: 2827-39. PMID 24887098 DOI: 10.1016/J.Jmb.2014.05.023  0.757
2014 Austin TM, Nannemann DP, Deluca SL, Meiler J, Delpire E. In silico analysis and experimental verification of OSR1 kinase - Peptide interaction. Journal of Structural Biology. 187: 58-65. PMID 24821279 DOI: 10.1016/J.Jsb.2014.05.001  0.763
2014 Gregory KJ, Nguyen ED, Malosh C, Mendenhall JL, Zic JZ, Bates BS, Noetzel MJ, Squire EF, Turner EM, Rook JM, Emmitte KA, Stauffer SR, Lindsley CW, Meiler J, Conn PJ. Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site. Acs Chemical Neuroscience. 5: 282-95. PMID 24528109 DOI: 10.1021/Cn400225X  0.3
2014 Sliwoski G, Kothiwale S, Meiler J, Lowe EW. Computational methods in drug discovery. Pharmacological Reviews. 66: 334-95. PMID 24381236 DOI: 10.1124/Pr.112.007336  0.306
2014 Pedragosa-Badia X, Sliwoski GR, Dong Nguyen E, Lindner D, Stichel J, Kaufmann KW, Meiler J, Beck-Sickinger AG. Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket. The Journal of Biological Chemistry. 289: 5846-59. PMID 24375409 DOI: 10.1074/Jbc.M113.502021  0.306
2014 Alexander NS, Preininger AM, Kaya AI, Stein RA, Hamm HE, Meiler J. Energetic analysis of the rhodopsin-G-protein complex links the α5 helix to GDP release. Nature Structural & Molecular Biology. 21: 56-63. PMID 24292645 DOI: 10.1038/Nsmb.2705  0.312
2014 Weiner BE, Alexander N, Akin LR, Woetzel N, Karakas M, Meiler J. BCL::Fold--protein topology determination from limited NMR restraints. Proteins. 82: 587-95. PMID 24123100 DOI: 10.1002/Prot.24427  0.355
2014 Allison B, Combs S, DeLuca S, Lemmon G, Mizoue L, Meiler J. Computational design of protein-small molecule interfaces. Journal of Structural Biology. 185: 193-202. PMID 23962892 DOI: 10.1016/J.Jsb.2013.08.003  0.317
2013 Duran AM, Meiler J. Inverted topologies in membrane proteins: a mini-review. Computational and Structural Biotechnology Journal. 8: e201308004. PMID 24688744 DOI: 10.5936/Csbj.201308004  0.306
2013 Thornburg NJ, Nannemann DP, Blum DL, Belser JA, Tumpey TM, Deshpande S, Fritz GA, Sapparapu G, Krause JC, Lee JH, Ward AB, Lee DE, Li S, Winarski KL, Spiller BW, ... Meiler J, et al. Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses. The Journal of Clinical Investigation. 123: 4405-9. PMID 23999429 DOI: 10.1172/Jci69377  0.746
2013 Figueroa M, Oliveira N, Lejeune A, Kaufmann KW, Dorr BM, Matagne A, Martial JA, Meiler J, Van de Weerdt C. Octarellin VI: using rosetta to design a putative artificial (β/α)8 protein. Plos One. 8: e71858. PMID 23977165 DOI: 10.1371/Journal.Pone.0071858  0.333
2013 Lindert S, Meiler J, McCammon JA. Iterative Molecular Dynamics-Rosetta Protein Structure Refinement Protocol to Improve Model Quality. Journal of Chemical Theory and Computation. 9: 3843-3847. PMID 23956701 DOI: 10.1021/Ct400260C  0.617
2013 Li F, Xia Y, Meiler J, Ferguson-Miller S. Characterization and modeling of the oligomeric state and ligand binding behavior of purified translocator protein 18 kDa from Rhodobacter sphaeroides. Biochemistry. 52: 5884-99. PMID 23952237 DOI: 10.1021/Bi400431T  0.31
2013 Nguyen ED, Norn C, Frimurer TM, Meiler J. Assessment and challenges of ligand docking into comparative models of G-protein coupled receptors. Plos One. 8: e67302. PMID 23844000 DOI: 10.1371/Journal.Pone.0067302  0.338
2013 Combs SA, Deluca SL, Deluca SH, Lemmon GH, Nannemann DP, Nguyen ED, Willis JR, Sheehan JH, Meiler J. Small-molecule ligand docking into comparative models with Rosetta. Nature Protocols. 8: 1277-98. PMID 23744289 DOI: 10.1038/Nprot.2013.074  0.785
2013 Weiner BE, Woetzel N, Karaka? M, Alexander N, Meiler J. BCL::MP-fold: folding membrane proteins through assembly of transmembrane helices. Structure (London, England : 1993). 21: 1107-17. PMID 23727232 DOI: 10.1016/J.Str.2013.04.022  0.335
2013 Aiyegbo MS, Sapparapu G, Spiller BW, Eli IM, Williams DR, Kim R, Lee DE, Liu T, Li S, Woods VL, Nannemann DP, Meiler J, Stewart PL, Crowe JE. Human rotavirus VP6-specific antibodies mediate intracellular neutralization by binding to a quaternary structure in the transcriptional pore. Plos One. 8: e61101. PMID 23671563 DOI: 10.1371/Journal.Pone.0061101  0.75
2013 Preininger AM, Meiler J, Hamm HE. Conformational flexibility and structural dynamics in GPCR-mediated G protein activation: a perspective. Journal of Molecular Biology. 425: 2288-98. PMID 23602809 DOI: 10.1016/J.Jmb.2013.04.011  0.308
2013 Leman JK, Mueller R, Karakas M, Woetzel N, Meiler J. Simultaneous prediction of protein secondary structure and transmembrane spans. Proteins. 81: 1127-40. PMID 23349002 DOI: 10.1002/Prot.24258  0.748
2013 Butkiewicz M, Lowe EW, Mueller R, Mendenhall JL, Teixeira PL, Weaver CD, Meiler J. Benchmarking ligand-based virtual High-Throughput Screening with the PubChem database. Molecules (Basel, Switzerland). 18: 735-56. PMID 23299552 DOI: 10.3390/Molecules18010735  0.301
2013 Lindert S, Stewart PL, Meiler J. Computational determination of the orientation of a heat repeat-like domain of DNA-PKcs. Computational Biology and Chemistry. 42: 1-4. PMID 23246775 DOI: 10.1016/J.Compbiolchem.2012.11.001  0.59
2013 Meiler J. Membrane Protein Structure Determination Through Assembly of Trans-Membrane Helices Guided by Limited Experimental Data Biophysical Journal. 104: 3-4. DOI: 10.1016/J.Bpj.2012.11.2142  0.326
2012 Kaufmann KW, Meiler J. Using RosettaLigand for small molecule docking into comparative models. Plos One. 7: e50769. PMID 23239984 DOI: 10.1371/Journal.Pone.0050769  0.317
2012 Woetzel N, Karaka? M, Staritzbichler R, Müller R, Weiner BE, Meiler J. BCL::Score--knowledge based energy potentials for ranking protein models represented by idealized secondary structure elements. Plos One. 7: e49242. PMID 23173051 DOI: 10.1371/Journal.Pone.0049242  0.326
2012 Karaka? M, Woetzel N, Staritzbichler R, Alexander N, Weiner BE, Meiler J. BCL::Fold--de novo prediction of complex and large protein topologies by assembly of secondary structure elements. Plos One. 7: e49240. PMID 23173050 DOI: 10.1371/Journal.Pone.0049240  0.331
2012 Lindert S, Alexander N, Wötzel N, Karaka? M, Stewart PL, Meiler J. EM-fold: de novo atomic-detail protein structure determination from medium-resolution density maps. Structure (London, England : 1993). 20: 464-78. PMID 22405005 DOI: 10.1016/J.Str.2012.01.023  0.59
2012 Eisenbeis S, Proffitt W, Coles M, Truffault V, Shanmugaratnam S, Meiler J, Höcker B. Potential of fragment recombination for rational design of proteins. Journal of the American Chemical Society. 134: 4019-22. PMID 22329686 DOI: 10.1021/Ja211657K  0.357
2012 Lindert S, Hofmann T, Wötzel N, Karaka? M, Stewart PL, Meiler J. Ab initio protein modeling into CryoEM density maps using EM-Fold. Biopolymers. 97: 669-77. PMID 22302372 DOI: 10.1002/Bip.22027  0.599
2012 Lemmon G, Meiler J. Rosetta Ligand docking with flexible XML protocols. Methods in Molecular Biology (Clifton, N.J.). 819: 143-55. PMID 22183535 DOI: 10.1007/978-1-61779-465-0_10  0.306
2011 Koehler J, Meiler J. Expanding the utility of NMR restraints with paramagnetic compounds: background and practical aspects. Progress in Nuclear Magnetic Resonance Spectroscopy. 59: 360-89. PMID 22027343 DOI: 10.1016/J.Pnmrs.2011.05.001  0.317
2011 Fortenberry C, Bowman EA, Proffitt W, Dorr B, Combs S, Harp J, Mizoue L, Meiler J. Exploring symmetry as an avenue to the computational design of large protein domains. Journal of the American Chemical Society. 133: 18026-9. PMID 21978247 DOI: 10.1021/Ja2051217  0.346
2011 Fleishman SJ, Leaver-Fay A, Corn JE, Strauch EM, Khare SD, Koga N, Ashworth J, Murphy P, Richter F, Lemmon G, Meiler J, Baker D. RosettaScripts: a scripting language interface to the Rosetta macromolecular modeling suite. Plos One. 6: e20161. PMID 21731610 DOI: 10.1371/Journal.Pone.0020161  0.789
2011 Woetzel N, Lindert S, Stewart PL, Meiler J. BCL::EM-Fit: rigid body fitting of atomic structures into density maps using geometric hashing and real space refinement. Journal of Structural Biology. 175: 264-76. PMID 21565271 DOI: 10.1016/J.Jsb.2011.04.016  0.572
2011 Ganguly S, Weiner BE, Meiler J. Membrane protein structure determination using paramagnetic tags. Structure (London, England : 1993). 19: 441-3. PMID 21481766 DOI: 10.1016/J.Str.2011.03.008  0.558
2011 Morin A, Kaufmann KW, Fortenberry C, Harp JM, Mizoue LS, Meiler J. Computational design of an endo-1,4-beta-xylanase ligand binding site. Protein Engineering, Design & Selection : Peds. 24: 503-16. PMID 21349882 DOI: 10.1093/Protein/Gzr006  0.598
2011 Morin A, Meiler J, Mizoue LS. Computational design of protein-ligand interfaces: potential in therapeutic development. Trends in Biotechnology. 29: 159-66. PMID 21295366 DOI: 10.1016/J.Tibtech.2011.01.002  0.591
2011 Leaver-Fay A, Tyka M, Lewis SM, Lange OF, Thompson J, Jacak R, Kaufman K, Renfrew PD, Smith CA, Sheffler W, Davis IW, Cooper S, Treuille A, Mandell DJ, Richter F, ... ... Meiler J, et al. ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules. Methods in Enzymology. 487: 545-74. PMID 21187238 DOI: 10.1016/B978-0-12-381270-4.00019-6  0.759
2011 Kazmier K, Alexander NS, Meiler J, McHaourab HS. Algorithm for selection of optimized EPR distance restraints for de novo protein structure determination. Journal of Structural Biology. 173: 549-57. PMID 21074624 DOI: 10.1016/J.Jsb.2010.11.003  0.32
2011 Hirst SJ, Alexander N, McHaourab HS, Meiler J. RosettaEPR: an integrated tool for protein structure determination from sparse EPR data. Journal of Structural Biology. 173: 506-14. PMID 21029778 DOI: 10.1016/J.Bpj.2010.12.1390  0.339
2011 Meiler J, Lindert S, Stewart P. De Novo Atomic-Detail Structure Prediction for Proteins Guided by Medium Resolution Density Maps Microscopy and Microanalysis. 17: 970-971. DOI: 10.1017/S1431927611005721  0.583
2011 Lindert S, Stewart P, Meiler J. Predicting Models for a Domain of DNA-PKcs Microscopy and Microanalysis. 17: 126-127. DOI: 10.1017/S1431927611001504  0.569
2011 DeLuca S, Meiler J. A Novel Method for Guiding Protein-Ligand Docking with QSAR-Derived Pharmacophore Maps Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.2344  0.327
2010 Kalkhof S, Haehn S, Paulsson M, Smyth N, Meiler J, Sinz A. Computational modeling of laminin N-terminal domains using sparse distance constraints from disulfide bonds and chemical cross-linking. Proteins. 78: 3409-27. PMID 20939100 DOI: 10.1002/Prot.22848  0.301
2010 Nannemann DP, Kaufmann KW, Meiler J, Bachmann BO. Design and directed evolution of a dideoxy purine nucleoside phosphorylase. Protein Engineering, Design & Selection : Peds. 23: 607-16. PMID 20525731 DOI: 10.1093/Protein/Gzq033  0.773
2010 Kaufmann KW, Lemmon GH, Deluca SL, Sheehan JH, Meiler J. Practically useful: what the Rosetta protein modeling suite can do for you. Biochemistry. 49: 2987-98. PMID 20235548 DOI: 10.1021/Bi902153G  0.37
2010 Karaka? M, Woetzel N, Meiler J. BCL::contact-low confidence fold recognition hits boost protein contact prediction and de novo structure determination. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 17: 153-68. PMID 19772383 DOI: 10.1089/Cmb.2009.0030  0.32
2010 Kazmier K, Alexander NS, Meiler J, Mchaourab HS. Optimal Selection of EPR Distance Restraints for Global Folding of Protein Structure Biophysical Journal. 98: 571a-572a. DOI: 10.1016/J.Bpj.2009.12.3104  0.319
2009 Farès C, Lakomek NA, Walter KF, Frank BT, Meiler J, Becker S, Griesinger C. Accessing ns-micros side chain dynamics in ubiquitin with methyl RDCs. Journal of Biomolecular Nmr. 45: 23-44. PMID 19652920 DOI: 10.1007/S10858-009-9354-7  0.447
2009 Lindert S, Staritzbichler R, Wötzel N, Karaka? M, Stewart PL, Meiler J. EM-fold: De novo folding of alpha-helical proteins guided by intermediate-resolution electron microscopy density maps. Structure (London, England : 1993). 17: 990-1003. PMID 19604479 DOI: 10.1016/J.Str.2009.06.001  0.585
2009 Friedland GD, Lakomek NA, Griesinger C, Meiler J, Kortemme T. A correspondence between solution-state dynamics of an individual protein and the sequence and conformational diversity of its family. Plos Computational Biology. 5: e1000393. PMID 19478996 DOI: 10.1371/Journal.Pcbi.1000393  0.665
2009 Lindert S, Stewart PL, Meiler J. Hybrid approaches: applying computational methods in cryo-electron microscopy. Current Opinion in Structural Biology. 19: 218-25. PMID 19339173 DOI: 10.1016/J.Sbi.2009.02.010  0.581
2009 Durham E, Dorr B, Woetzel N, Staritzbichler R, Meiler J. Solvent accessible surface area approximations for rapid and accurate protein structure prediction. Journal of Molecular Modeling. 15: 1093-108. PMID 19234730 DOI: 10.1007/S00894-009-0454-9  0.316
2009 Alexander N, Mchaourab H, Meiler J. Membrane Protein Structure Determination by Coupling Sparse Experimental Data with Protein Structure Prediction Techniques Biophysical Journal. 96: 654a. DOI: 10.1016/J.Bpj.2008.12.3455  0.326
2009 Lindert S, Staritzbichler R, Woetzel N, Karakas M, Stewart P, Meiler J. Cryo-EM Guided de novo Protein Fold Elucidation Biophysical Journal. 96: 654a. DOI: 10.1016/J.Bpj.2008.12.3454  0.607
2008 Lakomek NA, Lange OF, Walter KF, Farès C, Egger D, Lunkenheimer P, Meiler J, Grubmüller H, Becker S, de Groot BL, Griesinger C. Residual dipolar couplings as a tool to study molecular recognition of ubiquitin. Biochemical Society Transactions. 36: 1433-7. PMID 19021570 DOI: 10.1042/Bst0361433  0.496
2008 Lange OF, Lakomek NA, Farès C, Schröder GF, Walter KF, Becker S, Meiler J, Grubmüller H, Griesinger C, de Groot BL. Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution. Science (New York, N.Y.). 320: 1471-5. PMID 18556554 DOI: 10.1126/Science.1157092  0.472
2008 Lakomek NA, Walter KF, Farès C, Lange OF, de Groot BL, Grubmüller H, Brüschweiler R, Munk A, Becker S, Meiler J, Griesinger C. Self-consistent residual dipolar coupling based model-free analysis for the robust determination of nanosecond to microsecond protein dynamics. Journal of Biomolecular Nmr. 41: 139-55. PMID 18523727 DOI: 10.1007/S10858-008-9244-4  0.45
2008 Alexander N, Bortolus M, Al-Mestarihi A, Mchaourab H, Meiler J. De novo high-resolution protein structure determination from sparse spin-labeling EPR data. Structure (London, England : 1993). 16: 181-95. PMID 18275810 DOI: 10.1016/J.Str.2007.11.015  0.303
2007 Reese M, Sánchez-Pedregal VM, Kubicek K, Meiler J, Blommers MJJ, Griesinger C, Carlomagno T. Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution Angewandte Chemie - International Edition. 46: 1864-1868. PMID 17274084 DOI: 10.1002/Anie.200604505  0.455
2006 Zanghellini A, Jiang L, Wollacott AM, Cheng G, Meiler J, Althoff EA, Röthlisberger D, Baker D. New algorithms and an in silico benchmark for computational enzyme design. Protein Science : a Publication of the Protein Society. 15: 2785-94. PMID 17132862 DOI: 10.1110/Ps.062353106  0.759
2006 Sánchez-Pedregal VM, Kubicek K, Meiler J, Lyothier I, Paterson I, Carlomagno T. The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide Angewandte Chemie - International Edition. 45: 7388-7394. PMID 17036370 DOI: 10.1002/Anie.200602793  0.315
2006 Meiler J, Baker D. ROSETTALIGAND: protein-small molecule docking with full side-chain flexibility. Proteins. 65: 538-48. PMID 16972285 DOI: 10.1002/Prot.21086  0.431
2006 Lakomek NA, Carlomagno T, Becker S, Griesinger C, Meiler J. A thorough dynamic interpretation of residual dipolar couplings in ubiquitin Journal of Biomolecular Nmr. 34: 101-115. PMID 16518697 DOI: 10.1007/S10858-005-5686-0  0.452
2005 Lakomek NA, Farès C, Becker S, Carlomagno T, Meiler J, Griesinger C. Side-chain orientation and hydrogen-bonding imprint supra-τC motion on the protein backbone of ubiquitin Angewandte Chemie - International Edition. 44: 7776-7778. PMID 16276548 DOI: 10.1002/Anie.200502573  0.424
2005 Graña O, Baker D, MacCallum RM, Meiler J, Punta M, Rost B, Tress ML, Valencia A. CASP6 assessment of contact prediction. Proteins. 61: 214-24. PMID 16187364 DOI: 10.1002/Prot.20739  0.397
2005 Bradley P, Malmström L, Qian B, Schonbrun J, Chivian D, Kim DE, Meiler J, Misura KM, Baker D. Free modeling with Rosetta in CASP6. Proteins. 61: 128-34. PMID 16187354 DOI: 10.1002/Prot.20729  0.79
2005 Sánchez-Pedregal VM, Reese M, Meiler J, Blommers MJJ, Griesinger C, Carlomagno T. The INPHARMA method: Protein-mediated interligand NOEs for pharmacophore mapping Angewandte Chemie - International Edition. 44: 4172-4175. PMID 15929149 DOI: 10.1002/Anie.200500503  0.475
2005 Meiler J, Baker D. The fumarate sensor DcuS: progress in rapid protein fold elucidation by combining protein structure prediction methods with NMR spectroscopy. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 173: 310-6. PMID 15780923 DOI: 10.1016/J.Jmr.2004.11.031  0.451
2004 Griesinger C, Peti W, Meiler J, Brüschweiler R. Projection angle restraints for studying structure and dynamics of biomolecules Methods in Molecular Biology (Clifton, N.J.). 278: 107-121. PMID 15317994 DOI: 10.1385/1-59259-809-9:107  0.626
2004 Kuhn M, Meiler J, Baker D. Strand-loop-strand motifs: prediction of hairpins and diverging turns in proteins. Proteins. 54: 282-8. PMID 14696190 DOI: 10.1002/Prot.10589  0.4
2003 Meiler J, Baker D. Rapid protein fold determination using unassigned NMR data. Proceedings of the National Academy of Sciences of the United States of America. 100: 15404-9. PMID 14668443 DOI: 10.1073/Pnas.2434121100  0.449
2003 Bradley P, Chivian D, Meiler J, Misura KM, Rohl CA, Schief WR, Wedemeyer WJ, Schueler-Furman O, Murphy P, Schonbrun J, Strauss CE, Baker D. Rosetta predictions in CASP5: successes, failures, and prospects for complete automation. Proteins. 53: 457-68. PMID 14579334 DOI: 10.1002/Prot.10552  0.773
2003 Meiler J, Baker D. Coupled prediction of protein secondary and tertiary structure. Proceedings of the National Academy of Sciences of the United States of America. 100: 12105-10. PMID 14528006 DOI: 10.1073/Pnas.1831973100  0.429
2003 Meiler J, Peti W, Griesinger C. Dipolar couplings in multiple alignments suggest α helical motion in ubiquitin Journal of the American Chemical Society. 125: 8072-8073. PMID 12837055 DOI: 10.1021/Ja029816L  0.636
2003 Carlomagno T, Blommers MJJ, Meiler J, Jahnke W, Schupp T, Petersen F, Schinzer D, Altmann KH, Griesinger C. The high-resolution solution structure of epothilone A bound to tuhulin: An understanding of the structure-activity relationships for a powerful class of antitumor agents Angewandte Chemie - International Edition. 42: 2511-2515. PMID 12800173 DOI: 10.1002/Anie.200351276  0.439
2003 Meiler J. PROSHIFT: Protein chemical shift prediction using artificial neural networks Journal of Biomolecular Nmr. 26: 25-37. PMID 12766400 DOI: 10.1023/A:1023060720156  0.331
2003 Carlomagno T, Blommers MJJ, Meiler J, Jahnke W, Schupp T, Petersen F, Schinzer D, Altmann K, Griesinger C. Cover Picture: The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents (Angew. Chem. Int. Ed. 22/2003) Angewandte Chemie International Edition. 42: 2433-2433. DOI: 10.1002/Anie.200390473  0.432
2003 Carlomagno T, Blommers MJJ, Meiler J, Jahnke W, Schupp T, Petersen F, Schinzer D, Altmann K, Griesinger C. Titelbild: The High-Resolution Solution Structure of Epothilone A Bound to Tubulin: An Understanding of the Structure–Activity Relationships for a Powerful Class of Antitumor Agents (Angew. Chem. 22/2003) Angewandte Chemie. 115: 2537-2537. DOI: 10.1002/Ange.200390500  0.432
2002 Hutter MC, Krebs J, Meiler J, Griesinger C, Carafoli E, Helms V. A structural model of the complex formed by phospholamban and the calcium pump of sarcoplasmic reticulum obtained by molecular mechanics Chembiochem. 3: 1200-1208. PMID 12465028 DOI: 10.1002/1439-7633(20021202)3:12<1200::Aid-Cbic1200>3.0.Co;2-H  0.491
2002 Peti W, Meiler J, Brüschweiler R, Griesinger C. Model-free analysis of protein backbone motion from residual dipolar couplings Journal of the American Chemical Society. 124: 5822-5833. PMID 12010057 DOI: 10.1021/Ja011883C  0.631
2001 Carlomagno T, Blommers MJJ, Meiler J, Cuenoud B, Griesinger C. Determination of aliphatic side-chain conformation using cross-correlated relaxation: Application to an extraordinarily stable 2′-aminoethoxy-modified oligonucleotide triplex Journal of the American Chemical Society. 123: 7364-7370. PMID 11472167 DOI: 10.1021/Ja002592R  0.447
2001 Meiler J, Prompers JJ, Peti W, Griesinger C, Brüschweiler R. Model-free approach to the dynamic interpretation of residual dipolar couplings in globular proteins Journal of the American Chemical Society. 123: 6098-6107. PMID 11414844 DOI: 10.1021/Ja010002Z  0.636
2001 Neubauer H, Meiler J, Peti W, Griesinger C. NMR structure determination of saccharose and raffinose by means of homo- and heteronuclear dipolar couplings Helvetica Chimica Acta. 84: 243-258. DOI: 10.1002/1522-2675(20010131)84:1<243::Aid-Hlca243>3.0.Co;2-F  0.407
2000 Meiler J, Peti W, Griesinger C. DipoCoup: A versatile program for 3D-structure homology comparison based on residual dipolar couplings and pseudocontact shifts Journal of Biomolecular Nmr. 17: 283-294. PMID 11014592 DOI: 10.1023/A:1008362931964  0.648
2000 Meiler J, Blomberg N, Nilges M, Griesinger C. A new approach for applying residual dipolar couplings as restraints in structure elucidation Journal of Biomolecular Nmr. 16: 245-252. PMID 10805131 DOI: 10.1023/A:1008378624590  0.459
Low-probability matches (unlikely to be authored by this person)
2009 Koehler J, Woetzel N, Staritzbichler R, Sanders CR, Meiler J. A unified hydrophobicity scale for multispan membrane proteins. Proteins. 76: 13-29. PMID 19089980 DOI: 10.1002/Prot.22315  0.3
2008 Hanson SM, Dawson ES, Francis DJ, Van Eps N, Klug CS, Hubbell WL, Meiler J, Gurevich VV. A model for the solution structure of the rod arrestin tetramer. Structure (London, England : 1993). 16: 924-34. PMID 18547524 DOI: 10.1016/J.Str.2008.03.006  0.3
2014 Kroncke BM, Van Horn W, Vanoye C, Nannemann D, Meiler J, Sanders C. A Model of Human Potassium Channel KCNQ1 Modulation by Accessory Protein KCNE3 Biophysical Journal. 106: 143a. DOI: 10.1016/J.Bpj.2013.11.830  0.299
2011 Kaufmann K, Shen N, Mizoue L, Meiler J. A physical model for PDZ-domain/peptide interactions. Journal of Molecular Modeling. 17: 315-24. PMID 20461427 DOI: 10.1007/S00894-010-0725-5  0.299
2004 Meiler J, Köck M. Novel methods of automated structure elucidation based on 13C NMR spectroscopy Magnetic Resonance in Chemistry. 42: 1042-1045. PMID 15470690 DOI: 10.1002/Mrc.1424  0.299
2020 Muslinkina L, Gavrikov AS, Bozhanova NG, Mishin AS, Baranov MS, Meiler J, Pletneva NV, Pletnev VZ, Pletnev S. Structure-Based Rational Design of Two Enhanced Bacterial Lipocalin Tags for Protein-PAINT Super-resolution Microscopy. Acs Chemical Biology. PMID 32809793 DOI: 10.1021/Acschembio.0C00440  0.299
2013 Crivelli JJ, Lemmon G, Kaufmann KW, Meiler J. Simultaneous prediction of binding free energy and specificity for PDZ domain-peptide interactions. Journal of Computer-Aided Molecular Design. 27: 1051-65. PMID 24305904 DOI: 10.1007/S10822-013-9696-9  0.299
2011 DeLuca S, Dorr B, Meiler J. Design of native-like proteins through an exposure-dependent environment potential. Biochemistry. 50: 8521-8. PMID 21905701 DOI: 10.1021/Bi200664B  0.298
2013 Lemmon G, Meiler J. Towards ligand docking including explicit interface water molecules. Plos One. 8: e67536. PMID 23840735 DOI: 10.1371/Journal.Pone.0067536  0.298
2008 Dong E, Smith J, Heinze S, Alexander N, Meiler J. BCL::Align-sequence alignment and fold recognition with a custom scoring function online. Gene. 422: 41-6. PMID 18601985 DOI: 10.1016/J.Gene.2008.06.006  0.297
2016 Gajewski S, Waddell MB, Vaithiyalingam S, Nourse A, Li Z, Woetzel N, Alexander N, Meiler J, White SW. Structure and mechanism of the phage T4 recombination mediator protein UvsY. Proceedings of the National Academy of Sciences of the United States of America. PMID 26951671 DOI: 10.1073/Pnas.1519154113  0.297
2007 Smith JA, Vanoye CG, George AL, Meiler J, Sanders CR. Structural models for the KCNQ1 voltage-gated potassium channel Biochemistry. 46: 14141-14152. PMID 17999538 DOI: 10.1021/Bi701597S  0.296
2020 Brown BP, Mendenhall J, Lovly C, Meiler J. Abstract 22: Toward automated design of mutant-selective tyrosine kinase inhibitors using dynamic pharmacophore mapping and machine learning Clinical Cancer Research. 26: 22-22. DOI: 10.1158/1557-3265.Advprecmed20-22  0.295
2014 Mittendorf KF, Kroncke BM, Meiler J, Sanders CR. The homology model of PMP22 suggests mutations resulting in peripheral neuropathy disrupt transmembrane helix packing. Biochemistry. 53: 6139-41. PMID 25243937 DOI: 10.1021/Bi500809T  0.295
2019 Butkiewicz M, Rodriguez AL, Rainey SE, Wieting JM, Luscombe VB, Stauffer SR, Lindsley CW, Conn PJ, Meiler J. Identification of novel allosteric modulators of mGlu5 acting at site distinct from MPEP binding. Acs Chemical Neuroscience. PMID 31132237 DOI: 10.1021/Acschemneuro.8B00227  0.294
2020 Piotrowski C, Moretti R, Ihling CH, Haedicke A, Liepold T, Lipstein N, Meiler J, Jahn O, Sinz A. Delineating the Molecular Basis of the Calmodulin‒bMunc13-2 Interaction by Cross-Linking/Mass Spectrometry-Evidence for a Novel CaM Binding Motif in bMunc13-2. Cells. 9. PMID 31936129 DOI: 10.3390/Cells9010136  0.294
2011 Gregory KJ, Dong EN, Meiler J, Conn PJ. Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential. Neuropharmacology. 60: 66-81. PMID 20637216 DOI: 10.1016/J.Neuropharm.2010.07.007  0.294
2018 Roushar FJ, Gruenhagen TC, Penn WD, Li B, Meiler J, Jastrzebska B, Schlebach JP. Contribution of Cotranslational Folding Defects to Membrane Protein Homeostasis. Journal of the American Chemical Society. PMID 30537820 DOI: 10.1021/Jacs.8B08243  0.294
2019 Sevy AM, Wu NC, Gilchuk IM, Parrish EH, Burger S, Yousif D, Nagel MBM, Schey KL, Wilson IA, Crowe JE, Meiler J. Multistate design of influenza antibodies improves affinity and breadth against seasonal viruses. Proceedings of the National Academy of Sciences of the United States of America. PMID 30642961 DOI: 10.1073/pnas.1806004116  0.291
2015 Krug U, Alexander NS, Stein RA, Keim A, Mchaourab HS, Sträter N, Meiler J. Characterization of the Domain Orientations of E. coli 5'-Nucleotidase by Fitting an Ensemble of Conformers to DEER Distance Distributions. Structure (London, England : 1993). PMID 26724996 DOI: 10.1016/J.Str.2015.11.007  0.291
2015 Martin E, Knapp S, Engh RA, Moebitz H, Varin T, Roux B, Meiler J, Berdini V, Baumann A, Vieth M. Perspective on computational and structural aspects of kinase discovery from IPK2014. Biochimica Et Biophysica Acta. PMID 25861861 DOI: 10.1016/J.Bbapap.2015.03.014  0.291
2002 Meiler J, Will M. Genius: A genetic algorithm for automated structure elucidation from 13C NMR spectra Journal of the American Chemical Society. 124: 1868-1870. PMID 11866596 DOI: 10.1021/Ja0109388  0.29
2018 Lokits AD, Indrischek H, Meiler J, Hamm HE, Stadler PF. Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa. Bmc Evolutionary Biology. 18: 51. PMID 29642851 DOI: 10.1186/S12862-018-1147-8  0.289
2019 Gräb J, Berg A, Blechschmidt L, Klüver B, Rubner S, Fu DY, Meiler J, Gräber M, Berg T. The STAT5b linker domain mediates selectivity of catechol bisphosphates for STAT5b over STAT5a. Acs Chemical Biology. PMID 30835430 DOI: 10.1021/Acschembio.9B00137  0.288
2015 Gopal Vandavasi V, Putnam DK, Zhang Q, Petridis L, Heller WT, Nixon BT, Haigler CH, Kalluri U, Coates L, Langan P, Smith JC, Meiler J, O'Neill H. A Structural Study of CESA1 catalytic domain of Arabidopsis thaliana Cellulose Synthesis Complex: Evidence for CESA trimers. Plant Physiology. PMID 26556795 DOI: 10.1104/Pp.15.01356  0.287
2007 McKinney BA, Kallewaard NL, Crowe JE, Meiler J. Using the natural evolution of a rotavirus-specific human monoclonal antibody to predict the complex topography of a viral antigenic site. Immunome Research. 3: 8. PMID 17877819 DOI: 10.1186/1745-7580-3-8  0.286
2015 Swale DR, Sheehan JH, Banerjee S, Husni AS, Nguyen TT, Meiler J, Denton JS. Computational and functional analyses of a small-molecule binding site in ROMK. Biophysical Journal. 108: 1094-103. PMID 25762321 DOI: 10.1016/J.Bpj.2015.01.022  0.285
2020 Bozhanova NG, Gavrikov AS, Mishin AS, Meiler J. DiB-splits: nature-guided design of a novel fluorescent labeling split system. Scientific Reports. 10: 11049. PMID 32632329 DOI: 10.1038/S41598-020-67095-2  0.285
2015 Sali A, Berman HM, Schwede T, Trewhella J, Kleywegt G, Burley SK, Markley J, Nakamura H, Adams P, Bonvin AM, Chiu W, Peraro MD, Di Maio F, Ferrin TE, Grünewald K, ... ... Meiler J, et al. Outcome of the First wwPDB Hybrid/Integrative Methods Task Force Workshop. Structure (London, England : 1993). PMID 26095030 DOI: 10.1016/J.Str.2015.05.013  0.285
2016 Bornhop DJ, Kammer MN, Kussrow A, Flowers RA, Meiler J. Origin and prediction of free-solution interaction studies performed label-free. Proceedings of the National Academy of Sciences of the United States of America. PMID 26960999 DOI: 10.1073/Pnas.1515706113  0.284
2017 Voehler M, Ashoka MA, Meiler J, Bock PE. Carbon and amide detect backbone assignment methods of a novel repeat protein from the staphylocoagulase in S. aureus. Biomolecular Nmr Assignments. PMID 28819722 DOI: 10.1007/S12104-017-9757-4  0.284
2015 Vortmeier G, DeLuca SH, Els-Heindl S, Chollet C, Scheidt HA, Beck-Sickinger AG, Meiler J, Huster D. Integrating solid-state NMR and computational modeling to investigate the structure and dynamics of membrane-associated ghrelin. Plos One. 10: e0122444. PMID 25803439 DOI: 10.1371/Journal.Pone.0122444  0.284
2010 Mueller R, Rodriguez AL, Dawson ES, Butkiewicz M, Nguyen TT, Oleszkiewicz S, Bleckmann A, Weaver CD, Lindsley CW, Conn PJ, Meiler J. Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening. Acs Chemical Neuroscience. 1: 288-305. PMID 20414370 DOI: 10.1021/Cn9000389  0.284
2017 Schmidt P, Bender BJ, Kaiser A, Gulati K, Scheidt HA, Hamm HE, Meiler J, Beck-Sickinger AG, Huster D. Improved in Vitro Folding of the Y2 G Protein-Coupled Receptor into Bicelles. Frontiers in Molecular Biosciences. 4: 100. PMID 29387686 DOI: 10.3389/Fmolb.2017.00100  0.283
2011 Schreiber A, Meiler J. Structural forecasting: Modeling G-protein coupled receptors with ROSETTA | Modellierung G-Protein-gekoppelter Rezeptoren mit ROSETTA Biospektrum. 17: 158-161. DOI: 10.1007/S12268-011-0021-7  0.283
2001 Meiler J, Will M. Automated Structure Elucidation of Organic Molecules from 13C NMR Spectra Using Genetic Algorithms and Neural Networks Journal of Chemical Information and Computer Sciences. 41: 1535-1546. PMID 11749580 DOI: 10.1021/Ci0102970  0.282
2013 Putnam DK, Lowe EW, Meiler J. Reconstruction of SAXS Profiles from Protein Structures. Computational and Structural Biotechnology Journal. 8: e201308006. PMID 24688746 DOI: 10.5936/Csbj.201308006  0.282
2019 Vu O, Mendenhall J, Altarawy D, Meiler J. BCL::Mol2D-a robust atom environment descriptor for QSAR modeling and lead optimization. Journal of Computer-Aided Molecular Design. PMID 30955193 DOI: 10.1007/S10822-019-00199-8  0.282
2013 Gregory KJ, Nguyen ED, Reiff SD, Squire EF, Stauffer SR, Lindsley CW, Meiler J, Conn PJ. Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology. Molecular Pharmacology. 83: 991-1006. PMID 23444015 DOI: 10.1124/Mol.112.083949  0.281
2020 Zost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Nkolola JP, Schäfer A, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Martinez DR, Williamson LE, Chen EC, ... ... Meiler J, et al. Potently neutralizing and protective human antibodies against SARS-CoV-2. Nature. PMID 32668443 DOI: 10.1038/S41586-020-2548-6  0.28
2012 Kim M, Vishnivetskiy SA, Van Eps N, Alexander NS, Cleghorn WM, Zhan X, Hanson SM, Morizumi T, Ernst OP, Meiler J, Gurevich VV, Hubbell WL. Conformation of receptor-bound visual arrestin. Proceedings of the National Academy of Sciences of the United States of America. 109: 18407-12. PMID 23091036 DOI: 10.1073/Pnas.1216304109  0.28
2019 Ely ZA, Moon JM, Sliwoski GR, Sangha AK, Shen XX, Labella AL, Meiler J, Capra JA, Rokas A. The impact of natural selection on the evolution and function of placentally expressed galectins. Genome Biology and Evolution. PMID 31504490 DOI: 10.1093/Gbe/Evz183  0.279
2017 Lis C, Rubner S, Roatsch M, Berg A, Gilcrest T, Fu D, Nguyen E, Schmidt AM, Krautscheid H, Meiler J, Berg T. Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells. Scientific Reports. 7: 17390. PMID 29234062 DOI: 10.1038/S41598-017-17600-X  0.279
2011 Olmsted IR, Xiao Y, Cho M, Csordas AT, Sheehan JH, Meiler J, Soh HT, Bornhop DJ. Measurement of aptamer-protein interactions with back-scattering interferometry. Analytical Chemistry. 83: 8867-70. PMID 22032342 DOI: 10.1021/Ac202823M  0.278
2009 Kaufmann KW, Dawson ES, Henry LK, Field JR, Blakely RD, Meiler J. Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies. Proteins. 74: 630-42. PMID 18704946 DOI: 10.1002/Prot.22178  0.278
2019 Kroncke BM, Mendenhall J, Smith DK, Sanders CR, Capra JA, George AL, Blume JD, Meiler J, Roden DM. Protein structure aids predicting functional perturbation of missense variants in and . Computational and Structural Biotechnology Journal. 17: 206-214. PMID 30828412 DOI: 10.1016/J.Csbj.2019.01.008  0.277
2016 Huster D, Kaiser A, Kahr J, Zellmann T, Scheidt HA, Meier R, Meiler J, Beck-Sickinger AG, Schmidt P. Structural Dynamics of the Ligand-Receptor Interaction of the Neuropeptide Y Receptor Type 2 Biophysical Journal. 110: 2-5. DOI: 10.1016/J.Bpj.2015.11.1246  0.277
2010 Hirst S, Alexander N, Kaufmann K, Mchaourab H, Meiler J. Rosettaepr: Developing Protein Structure Prediction Methods using Sparse SDSL-EPR Data Biophysical Journal. 98: 461a-462a. DOI: 10.1016/J.Bpj.2009.12.2508  0.276
2019 Meiler J. Integrated Structural Biology for Alpha-Helical Membrane Protein Structure Determination Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.1791  0.276
2016 Mousa JJ, Sauer MF, Sevy AM, Finn JA, Bates JT, Alvarado G, King HG, Loerinc LB, Fong RH, Doranz BJ, Correia BE, Kalyuzhniy O, Wen X, Jardetzky TS, Schief WR, ... ... Meiler J, et al. Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791117 DOI: 10.1073/Pnas.1609449113  0.276
2011 Van Eps N, Preininger AM, Alexander N, Kaya AI, Meier S, Meiler J, Hamm HE, Hubbell WL. Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit. Proceedings of the National Academy of Sciences of the United States of America. 108: 9420-4. PMID 21606326 DOI: 10.1073/Pnas.1105810108  0.275
2016 Dastvan R, Fischer AW, Mishra S, Meiler J, Mchaourab HS. Structural Dynamics of the Small Multidrug Transporter EMRE Biophysical Journal. 110: 135a. DOI: 10.1016/J.Bpj.2015.11.775  0.275
2011 DeLuca S, Dorr B, Meiler J. Correction to Design of Native-like Proteins through an Exposure-Dependent Environment Potential Biochemistry. 50: 10986-10986. DOI: 10.1021/Bi201611H  0.275
2017 Sangha AK, Dong J, Williamson L, Hashiguchi T, Saphire EO, Crowe JE, Meiler J. Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein. Structure (London, England : 1993). PMID 29153506 DOI: 10.1016/J.Str.2017.10.005  0.275
2014 Wu H, Wang C, Gregory KJ, Han GW, Cho HP, Xia Y, Niswender CM, Katritch V, Meiler J, Cherezov V, Conn PJ, Stevens RC. Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. Science (New York, N.Y.). 344: 58-64. PMID 24603153 DOI: 10.1126/Science.1249489  0.275
2014 Conn PJ, Lindsley CW, Meiler J, Niswender CM. Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders. Nature Reviews. Drug Discovery. 13: 692-708. PMID 25176435 DOI: 10.1038/Nrd4308  0.274
2002 Meiler J, Sanli E, Junker J, Meusinger R, Lindel T, Will M, Maier W, Köck M. Validation of structural proposals by substructure analysis and 13C NMR chemical shift prediction Journal of Chemical Information and Computer Sciences. 42: 241-248. DOI: 10.1021/Ci010294N  0.274
2017 Kothiwale S, Borza C, Pozzi A, Meiler J. Quantitative Structure-Activity Relationship Modeling of Kinase Selectivity Profiles. Molecules (Basel, Switzerland). 22. PMID 28925954 DOI: 10.3390/Molecules22091576  0.274
2013 Alexander NS, Stein RA, Koteiche HA, Kaufmann KW, McHaourab HS, Meiler J. RosettaEPR: rotamer library for spin label structure and dynamics. Plos One. 8: e72851. PMID 24039810 DOI: 10.1371/Journal.Pone.0072851  0.272
2016 Dastvan R, Fischer AW, Mishra S, Meiler J, Mchaourab HS. Protonation-dependent conformational dynamics of the multidrug transporter EmrE. Proceedings of the National Academy of Sciences of the United States of America. PMID 26787875 DOI: 10.1073/Pnas.1520431113  0.272
2010 Dave S, Sheehan JH, Meiler J, Strange K. Unique gating properties of C. elegans ClC anion channel splice variants are determined by altered CBS domain conformation and the R-helix linker. Channels (Austin, Tex.). 4: 289-301. PMID 20581474 DOI: 10.4161/Chan.4.4.12445  0.271
2012 Rathmann D, Lindner D, DeLuca SH, Kaufmann KW, Meiler J, Beck-Sickinger AG. Ligand-mimicking receptor variant discloses binding and activation mode of prolactin-releasing peptide. The Journal of Biological Chemistry. 287: 32181-94. PMID 22778259 DOI: 10.1074/Jbc.M112.349852  0.271
2018 King LB, Fusco ML, Flyak AI, Ilinykh PA, Huang K, Gunn B, Kirchdoerfer RN, Hastie KM, Sangha AK, Meiler J, Alter G, Bukreyev A, Crowe JE, Saphire EO. The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding. Cell Host & Microbe. 23: 101-109.e4. PMID 29324225 DOI: 10.1016/J.Chom.2017.12.003  0.271
2016 Mendenhall J, Meiler J. Improving quantitative structure-activity relationship models using Artificial Neural Networks trained with dropout. Journal of Computer-Aided Molecular Design. PMID 26830599 DOI: 10.1007/S10822-016-9895-2  0.27
2018 Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, ... ... Meiler J, et al. Structural basis of ligand binding modes at the neuropeptide Y Y receptor. Nature. PMID 29670288 DOI: 10.1038/S41586-018-0046-X  0.27
2013 Yang T, Smith JA, Leake BF, Sanders CR, Meiler J, Roden DM. An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1. Molecular Pharmacology. 83: 481-9. PMID 23193163 DOI: 10.1124/Mol.112.081513  0.269
2016 Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE. A conserved hydrophobic core in Gαi1 regulates G protein activation and release from activated receptor. The Journal of Biological Chemistry. PMID 27462082 DOI: 10.1074/Jbc.M116.745513  0.268
2018 Huang H, Kuenze G, Smith JA, Taylor KC, Duran AM, Hadziselimovic A, Meiler J, Vanoye CG, George AL, Sanders CR. Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations. Science Advances. 4: eaar2631. PMID 29532034 DOI: 10.1126/Sciadv.Aar2631  0.268
2016 Vandavasi VG, Putnam DK, Zhang Q, Petridis L, Heller WT, Nixon BT, Haigler CH, Kalluri U, Coates L, Langan P, Smith JC, Meiler J, O'Neill H. Structural Studies of Plant CESA Support Eighteen CESAs in the Plant CSC Biophysical Journal. 110: 27a. DOI: 10.1016/J.Bpj.2015.11.208  0.268
2020 Maddur AA, Kroh HK, Aschenbrenner ME, Gibson BH, Panizzi P, Sheehan JH, Meiler J, Bock PE, Verhamme IM. Specificity and affinity of the N-terminal residues in staphylocoagulase in binding to prothrombin. The Journal of Biological Chemistry. PMID 32156702 DOI: 10.1074/Jbc.Ra120.012588  0.267
2015 Willis JR, Sapparapu G, Murrell S, Julien JP, Singh V, King HG, Xia Y, Pickens JA, LaBranche CC, Slaughter JC, Montefiori DC, Wilson IA, Meiler J, Crowe JE. Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth. The Journal of Clinical Investigation. 125: 2523-31. PMID 25985274 DOI: 10.1172/Jci80693  0.267
2012 Sliwoski G, Lowe EW, Butkiewicz M, Meiler J. BCL::EMAS--enantioselective molecular asymmetry descriptor for 3D-QSAR. Molecules (Basel, Switzerland). 17: 9971-89. PMID 22907158 DOI: 10.3390/Molecules17089971  0.267
2017 Kharade S, Sheehan J, Figueroa E, Meiler J, Denton J. Pore polarity and charge determine differential block of Kir1.1 and Kir7.1 potassium channels by the small-molecule inhibitor VU590. Molecular Pharmacology. PMID 28619748 DOI: 10.1124/Mol.117.108472  0.266
2002 Meiler J, Maier W, Will M, Meusinger R. Using neural networks for 13C NMR chemical shift prediction-comparison with traditional methods Journal of Magnetic Resonance. 157: 242-252. PMID 12323143 DOI: 10.1006/Jmre.2002.2599  0.266
2015 Kothiwale S, Borza CM, Lowe EW, Pozzi A, Meiler J. Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery. Drug Discovery Today. 20: 255-61. PMID 25284748 DOI: 10.1016/J.Drudis.2014.09.025  0.266
2013 Willis JR, Briney BS, DeLuca SL, Crowe JE, Meiler J. Human germline antibody gene segments encode polyspecific antibodies. Plos Computational Biology. 9: e1003045. PMID 23637590 DOI: 10.1371/Journal.Pcbi.1003045  0.265
2018 Huster D, Vortmeier G, Schrottke S, Els-Heindl S, DeLuca S, Bender B, Beck-Sickinger A, Meiler J. Dynamics and Ligand Binding of the GHS G Protein-Coupled Receptor in Lipid Membranes Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.163  0.265
2010 Hoffman L, Kaufmann K, Colbran R, Meiler J, Mchaourab H. Conformational Changes of CaMKII: A Model of Activation Biophysical Journal. 98: 675a. DOI: 10.1016/J.Bpj.2009.12.3710  0.264
2010 Lowe EW, Ferrebee A, Rodriguez AL, Conn PJ, Meiler J. 3D-QSAR CoMFA study of benzoxazepine derivatives as mGluR5 positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 20: 5922-4. PMID 20732812 DOI: 10.1016/J.Bmcl.2010.07.061  0.264
2013 Schmidt P, Ritscher L, Dong EN, Hermsdorf T, Cöster M, Wittkopf D, Meiler J, Schöneberg T. Identification of determinants required for agonistic and inverse agonistic ligand properties at the ADP receptor P2Y12. Molecular Pharmacology. 83: 256-66. PMID 23093496 DOI: 10.1124/Mol.112.082198  0.264
2008 Kang C, Tian C, Sönnichsen FD, Smith JA, Meiler J, George AL, Vanoye CG, Kim HJ, Sanders CR. Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel. Biochemistry. 47: 7999-8006. PMID 18611041 DOI: 10.1021/Bi800875Q  0.264
2013 Deluca SH, Rathmann D, Beck-Sickinger AG, Meiler J. The activity of prolactin releasing peptide correlates with its helicity. Biopolymers. 99: 314-25. PMID 23426574 DOI: 10.1002/Bip.22162  0.263
2003 Bleckmann A, Meiler J. Epothilones: Quantitative Structure Activity Relations Studied by Support Vector Machines and Artificial Neural Networks Qsar and Combinatorial Science. 22: 722-728. DOI: 10.1002/Qsar.200330837  0.262
2017 Vanoye CG, Desai RR, Fabre KL, Meiler J, Sanders CR, George AL. Functional Annotation of KCNQ1 Variants of Unknown Significance using Automated Electrophysiology Biophysical Journal. 112: 410a. DOI: 10.1016/J.Bpj.2016.11.2556  0.261
2012 Findeisen M, Würker C, Rathmann D, Meier R, Meiler J, Olsson R, Beck-Sickinger AG. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. Journal of Medicinal Chemistry. 55: 6124-36. PMID 22708927 DOI: 10.1021/Jm300535S  0.261
2012 Mueller R, Dawson ES, Meiler J, Rodriguez AL, Chauder BA, Bates BS, Felts AS, Lamb JP, Menon UN, Jadhav SB, Kane AS, Jones CK, Gregory KJ, Niswender CM, Conn PJ, et al. Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGluâ‚…): from an artificial neural network virtual screen to an in vivo tool compound. Chemmedchem. 7: 406-14. PMID 22267125 DOI: 10.1002/Cmdc.201100510  0.261
2017 Schubert M, Stichel J, Du Y, Tough IR, Sliwoski G, Meiler J, Cox HM, Weaver CD, Beck-Sickinger AG. Identification and Characterization of the First Selective Y4 Receptor Positive Allosteric Modulator. Journal of Medicinal Chemistry. PMID 28795803 DOI: 10.1021/Acs.Jmedchem.7B00976  0.26
2013 Turlington M, Noetzel MJ, Chun A, Zhou Y, Gogliotti RD, Nguyen ED, Gregory KJ, Vinson PN, Rook JM, Gogi KK, Xiang Z, Bridges TM, Daniels JS, Jones C, Niswender CM, ... Meiler J, et al. Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254). Journal of Medicinal Chemistry. 56: 7976-96. PMID 24050755 DOI: 10.1021/Jm401028T  0.26
2019 Bender B, Vortmeier G, Ernicke S, Bosse M, Kaiser A, Els-Heindl S, Krug U, Beck-Sickinger A, Meiler J, Huster D. Ghrelin Binding at its G Protein-Coupled Receptor Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr27600  0.26
2011 Combs S, Kaufmann K, Field JR, Blakely RD, Meiler J. Y95 and E444 interaction required for high-affinity S-citalopram binding in the human serotonin transporter. Acs Chemical Neuroscience. 2: 75-81. PMID 22778858 DOI: 10.1021/Cn100066P  0.26
2015 Kroncke BM, Vanoye CG, Meiler J, George AL, Sanders CR. Personalized biochemistry and biophysics. Biochemistry. 54: 2551-9. PMID 25856502 DOI: 10.1021/Acs.Biochem.5B00189  0.257
2018 Sivley RM, Sheehan JH, Kropski JA, Cogan J, Blackwell TS, Phillips JA, Bush WS, Meiler J, Capra JA. Three-dimensional spatial analysis of missense variants in RTEL1 identifies pathogenic variants in patients with Familial Interstitial Pneumonia. Bmc Bioinformatics. 19: 18. PMID 29361909 DOI: 10.1186/S12859-018-2010-Z  0.257
2019 He MY, Li WK, Meiler J, Zheng QC, Zhang HX. Insight on mutation-induced resistance to anaplastic lymphoma kinase inhibitor ceritinib from molecular dynamics simulations. Biopolymers. e23257. PMID 30664251 DOI: 10.1002/Bip.23257  0.257
2016 Schmidt P, Kaiser A, Bender BJ, Meiler J, Beck-Sickinger AG, Huster D. High yield in vitro folding of the Y2 receptor into bicelles for structural studies Neuropeptides. 55: 15. DOI: 10.1016/J.Npep.2015.11.041  0.256
2020 Penn WD, McKee AG, Kuntz CP, Woods H, Nash V, Gruenhagen TC, Roushar FJ, Chandak M, Hemmerich C, Rusch DB, Meiler J, Schlebach JP. Probing biophysical sequence constraints within the transmembrane domains of rhodopsin by deep mutational scanning. Science Advances. 6: eaay7505. PMID 32181350 DOI: 10.1126/Sciadv.Aay7505  0.255
2020 Schmitz S, Soto C, Crowe JE, Meiler J. Human-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoires. Mabs. 12: 1758291. PMID 32397786 DOI: 10.1080/19420862.2020.1758291  0.255
2018 Schoeder CT, Hess C, Madea B, Meiler J, Müller CE. Pharmacological evaluation of new constituents of "Spice": synthetic cannabinoids based on indole, indazole, benzimidazole and carbazole scaffolds. Forensic Toxicology. 36: 385-403. PMID 29963207 DOI: 10.1007/S11419-018-0415-Z  0.255
2012 Mueller R, Dawson ES, Niswender CM, Butkiewicz M, Hopkins CR, Weaver CD, Lindsley CW, Conn PJ, Meiler J. Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators. Journal of Molecular Modeling. 18: 4437-46. PMID 22592386 DOI: 10.1007/S00894-012-1441-0  0.254
2016 Sliwoski G, Schubert M, Stichel J, Weaver D, Beck-Sickinger AG, Meiler J. Discovery of Small-Molecule Modulators of the Human Y4 Receptor. Plos One. 11: e0157146. PMID 27294784 DOI: 10.1371/Journal.Pone.0157146  0.254
2017 Croessmann S, Sheehan JH, Lee KM, Sliwoski GR, He J, Nagy RJ, Riddle DA, Mayer IA, Balko JM, Lanman RB, Miller V, Cantley LC, Meiler J, Arteaga CL. PIK3CA C2 domain deletions hyperactivate phosphoinositide 3-kinase (PI3K), generate oncogene dependence and are exquisitely sensitive to PI3Kα inhibitors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29284706 DOI: 10.1158/1078-0432.Ccr-17-2141  0.253
2018 Kharade SV, Kurata H, Bender A, Blobaum AL, Figueroa EE, Duran AM, Kramer M, Days E, Vinson P, Flores D, Satlin LM, Meiler J, Weaver CD, Lindsley CW, Hopkins CR, et al. Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992. Molecular Pharmacology. PMID 29895592 DOI: 10.1124/Mol.118.112359  0.253
2012 Lemmon G, Kaufmann K, Meiler J. Prediction of HIV-1 protease/inhibitor affinity using RosettaLigand. Chemical Biology & Drug Design. 79: 888-96. PMID 22321894 DOI: 10.1111/J.1747-0285.2012.01356.X  0.252
2016 Swale DR, Kurata H, Kharade SV, Sheehan JH, Raphemot RR, Voigtritter KR, Figueroa E, Meiler J, Flobaum AL, Lindsley CW, Hopkins CR, Denton JS. ML418: The first selective, sub-micromolar pore blocker of Kir7.1 potassium channels. Acs Chemical Neuroscience. PMID 27184474 DOI: 10.1021/Acschemneuro.6B00111  0.252
2000 Meiler J, Meusinger R, Will M. Fast determination of 13C NMR chemical shifts using artificial neural networks Journal of Chemical Information and Computer Sciences. 40: 1169-1176. PMID 11045810 DOI: 10.1021/Ci000021C  0.252
2016 Geanes AR, Cho HP, Nance KD, McGowan KM, Conn PJ, Jones CK, Meiler J, Lindsley CW. Ligand-based virtual screen for the discovery of novel M5 inhibitor chemotypes. Bioorganic & Medicinal Chemistry Letters. PMID 27503678 DOI: 10.1016/J.Bmcl.2016.07.071  0.252
2001 Meiler J, Müller M, Zeidler A, Schmäschke F. Generation and evaluation of dimension-reduced amino acid parameter representations by artificial neural networks Journal of Molecular Modeling. 7: 360-369. DOI: 10.1007/S008940100038  0.25
2018 Kratochvil I, Hofmann T, Rother S, Schlichting R, Moretti R, Scharnweber D, Hintze V, Escher BI, Meiler J, Kalkhof S, von Bergen M. MEHP and MEOHP but not DEHP bind productively to the peroxisome proliferator-activated receptor γ. Rapid Communications in Mass Spectrometry : Rcm. PMID 30085373 DOI: 10.1002/Rcm.8258  0.25
2014 Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE. A conserved phenylalanine as a relay between the α5 helix and the GDP binding region of heterotrimeric Gi protein α subunit. The Journal of Biological Chemistry. 289: 24475-87. PMID 25037222 DOI: 10.1074/Jbc.M114.572875  0.249
2020 Sevy AM, Gilchuk IM, Brown BP, Bozhanova NG, Nargi R, Jensen M, Meiler J, Crowe JE. Computationally Designed Cyclic Peptides Derived from an Antibody Loop Increase Breadth of Binding for Influenza Variants. Structure (London, England : 1993). PMID 32610044 DOI: 10.1016/J.Str.2020.04.005  0.249
2014 Jaeschke H, Schaarschmidt J, Eszlinger M, Huth S, Puttinger R, Rittinger O, Meiler J, Paschke R. A newly discovered TSHR variant (L665F) associated with nonautoimmune hyperthyroidism in an Austrian family induces constitutive TSHR activation by steric repulsion between TM1 and TM7. The Journal of Clinical Endocrinology and Metabolism. 99: E2051-9. PMID 24947036 DOI: 10.1055/S-0034-1372106  0.248
2020 Soto C, Finn JA, Willis JR, Day SB, Sinkovits RS, Jones T, Schmitz S, Meiler J, Branchizio A, Crowe JE. PyIR: a scalable wrapper for processing billions of immunoglobulin and T cell receptor sequences using IgBLAST. Bmc Bioinformatics. 21: 314. PMID 32677886 DOI: 10.1186/S12859-020-03649-5  0.248
2009 Fallen K, Banerjee S, Sheehan J, Addison D, Lewis LM, Meiler J, Denton JS. The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating. Channels (Austin, Tex.). 3: 57-68. PMID 19221509 DOI: 10.4161/Chan.3.1.7817  0.247
2017 Berenger F, Vu O, Meiler J. Consensus queries in ligand-based virtual screening experiments. Journal of Cheminformatics. 9: 60. PMID 29185065 DOI: 10.1186/S13321-017-0248-5  0.247
2011 Bhave G, Chauder BA, Liu W, Dawson ES, Kadakia R, Nguyen TT, Lewis LM, Meiler J, Weaver CD, Satlin LM, Lindsley CW, Denton JS. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Molecular Pharmacology. 79: 42-50. PMID 20926757 DOI: 10.1124/Mol.110.066928  0.247
2019 Du Z, Gallant J, Red-Brewer M, Brown B, Sheehan J, Meiler J, Lovly CM. Abstract 867: EGFR kinase domain duplication (EGFR-KDD) is activated by asymmetric intra-molecular dimerization Cancer Research. 79: 867-867. DOI: 10.1158/1538-7445.Am2019-867  0.246
2019 Bennett MR, Dong J, Bombardi RG, Soto C, Parrington HM, Nargi RS, Schoeder CT, Nagel MB, Schey KL, Meiler J, Skaar EP, Crowe JE. Human Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis. Mbio. 10. PMID 31641091 DOI: 10.1128/Mbio.02473-19  0.246
2016 Kaiser A, Müller P, Zellmann T, Scheidt HA, Meier R, Meiler J, Huster D, Schmidt P, Beck-Sickinger AG. Hydrophobic contacts specifically contribute to peptide binding at the neuropeptide Y2 receptor Neuropeptides. 55: 16. DOI: 10.1016/J.Npep.2015.11.043  0.246
2020 Sinatra L, Bandolik JJ, Roatsch M, Sönnichsen M, Schoeder CT, Hamacher A, Schoeler A, Borkhardt A, Meiler J, Bhatia S, Kassack MU, Hansen FK. Hydroxamic Acids Immobilized on Resins (HAIRs): A Toolbox for the Synthesis of Dual-Targeting HDAC Inhibitors and HDAC Degraders (PROTACs). Angewandte Chemie (International Ed. in English). PMID 32780485 DOI: 10.1002/Anie.202006725  0.243
2014 Mäde V, Bellmann-Sickert K, Kaiser A, Meiler J, Beck-Sickinger AG. Position and length of fatty acids strongly affect receptor selectivity pattern of human pancreatic polypeptide analogues. Chemmedchem. 9: 2463-74. PMID 25156249 DOI: 10.1002/Cmdc.201402235  0.242
2020 Brewer KR, Kuenze G, Vanoye CG, George AL, Meiler J, Sanders CR. Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome. Frontiers in Pharmacology. 11: 550. PMID 32431610 DOI: 10.3389/Fphar.2020.00550  0.241
2020 Park Y, Sanders CR, Meiler J. Structural Insight of the Complex of TREM2 and DAP12 in Membrane Bilayer Biophysical Journal. 118: 525a. DOI: 10.1016/J.Bpj.2019.11.2886  0.241
2009 Stepanovic SZ, Potet F, Petersen CI, Smith JA, Meiler J, Balser JR, Kupershmidt S. The evolutionarily conserved residue A653 plays a key role in HERG channel closing. The Journal of Physiology. 587: 2555-66. PMID 19406877 DOI: 10.1113/Jphysiol.2008.166694  0.24
2017 Brüser A, Zimmermann A, Crews BC, Sliwoski G, Meiler J, König GM, Kostenis E, Lede V, Marnett LJ, Schöneberg T. Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6. Scientific Reports. 7: 2380. PMID 28539604 DOI: 10.1038/S41598-017-02414-8  0.24
2018 Mao J, Kuenze G, Joedicke L, Meiler J, Michel H, Glaubitz C. Backbone structure of Des-Arg10-Kallidin (DAKD) peptide bound to human Bradykinin 1 Receptor (B1R) determined by DNP-enhanced MAS SSNMR Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr34209  0.239
2016 Kaiser A, Müller P, Kahr J, Zellmann T, Scheidt HA, Thomas L, Bosse M, Meier R, Meiler J, Beck-Sickinger AG, Schmidt P, Huster D. Structural dynamics of the ligand–receptor interaction of the neuropeptide Y receptor type 2 Neuropeptides. 55: 9-10. DOI: 10.1016/J.Npep.2015.11.023  0.239
2020 Taylor KC, Kang PW, Hou P, Yang ND, Kuenze G, Smith JA, Shi J, Huang H, White KM, Peng D, George AL, Meiler J, McFeeters RL, Cui J, Sanders CR. Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state. Elife. 9. PMID 32096762 DOI: 10.7554/Elife.53901  0.238
2010 Lebois EP, Bridges TM, Lewis LM, Dawson ES, Kane AS, Xiang Z, Jadhav SB, Yin H, Kennedy JP, Meiler J, Niswender CM, Jones CK, Conn PJ, Weaver CD, Lindsley CW. Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system. Acs Chemical Neuroscience. 1: 104-121. PMID 21961051 DOI: 10.1021/Cn900003H  0.235
1999 Meiler J, Meusinger R, Will M. Neural network prediction of 13C NMR chemical shifts of substituted benzenes Monatshefte Fur Chemie. 130: 1089-1095. DOI: 10.1007/Pl00010287  0.235
2015 Sliwoski G, Mendenhall J, Meiler J. Autocorrelation descriptor improvements for QSAR: 2DA_Sign and 3DA_Sign. Journal of Computer-Aided Molecular Design. PMID 26721261 DOI: 10.1007/S10822-015-9893-9  0.234
2019 Brown BP, Zhang YK, Westover D, Yan Y, Qiao H, Huang V, Du Z, Smith JA, Ross JS, Miller VA, Ali SM, Bazhenova L, Schrock AB, Meiler J, Lovly CM. On-target resistance to the mutant-selective EGFR inhibitor osimertinib can develop in an allele specific manner dependent on the original EGFR activating mutation. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30796031 DOI: 10.1158/1078-0432.Ccr-18-3829  0.232
2016 Bender B, Schmidt P, Kaiser A, Beck-Sickinger A, Huster D, Meiler J. Structure and dynamic signaling of the Y2 receptor Neuropeptides. 55: 14-15. DOI: 10.1016/J.Npep.2015.11.039  0.232
2024 Ertelt M, Mulligan VK, Maguire JB, Lyskov S, Moretti R, Schiffner T, Meiler J, Schoeder CT. Combining machine learning with structure-based protein design to predict and engineer post-translational modifications of proteins. Plos Computational Biology. 20: e1011939. PMID 38484014 DOI: 10.1371/journal.pcbi.1011939  0.231
2016 Zellmann T, Burkert K, Kaiser A, Meier R, Meiler J, Huster D, Schmidt P, Beck-Sickinger AG. Comparison of agonist and antagonist binding sites of the neuropeptide Y receptor 2 Neuropeptides. 55: 17. DOI: 10.1016/J.Npep.2015.11.046  0.231
2019 Sevy AM, Soto C, Bombardi RG, Meiler J, Crowe JE. Immune repertoire fingerprinting by principal component analysis reveals shared features in subject groups with common exposures. Bmc Bioinformatics. 20: 629. PMID 31801472 DOI: 10.1186/S12859-019-3281-8  0.23
2016 Willis JR, Finn JA, Briney B, Sapparapu G, Singh V, King H, LaBranche CC, Montefiori DC, Meiler J, Crowe JE. Long antibody HCDR3s from HIV-naïve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization. Proceedings of the National Academy of Sciences of the United States of America. PMID 27044078 DOI: 10.1073/Pnas.1518405113  0.23
2019 Campbell NG, Shekar A, Aguilar JI, Peng D, Navratna V, Yang D, Morley AN, Duran AM, Galli G, O'Grady B, Ramachandran R, Sutcliffe JS, Sitte HH, Erreger K, Meiler J, et al. Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in . Proceedings of the National Academy of Sciences of the United States of America. PMID 30755521 DOI: 10.1073/Pnas.1816247116  0.23
2012 Coles M, Truffault V, Eisenbeis S, Proffitt W, Meiler J, Hocker B. Computational design of an eight-stranded (beta/alpha)-barrel from fragments of different folds Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Lle/Pdb  0.229
2020 Hanker AB, Jayanthan HS, Ye D, Lin C, Akamatsu H, Sheehan JH, Koch JP, Sudhan DR, Brewer MR, Servetto A, He J, Miller VA, Lalani AS, Meiler J, Arteaga CL. Abstract GS6-04: Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, breast cancer progression, and HER2 inhibitor sensitivity Cancer Research. 80. DOI: 10.1158/1538-7445.Sabcs19-Gs6-04  0.228
2023 Sala D, Hildebrand PW, Meiler J. Biasing AlphaFold2 to predict GPCRs and kinases with user-defined functional or structural properties. Frontiers in Molecular Biosciences. 10: 1121962. PMID 36876042 DOI: 10.3389/fmolb.2023.1121962  0.228
2017 Croessmann S, Sheehan J, Sliwoski G, Leelatian N, He J, Nagy R, Balko JM, Mayer IA, Lanman RB, Miller V, Cantley LC, Irish JM, Meiler J, Arteaga CL. Abstract 1772:PIK3CAC2 domain deletions hyperactivate PI3K, generate oncogene dependence and are exquisitely sensitive to PI3Kα inhibitors Cancer Research. 77: 1772-1772. DOI: 10.1158/1538-7445.Am2017-1772  0.228
2020 Vanoye CG, Desai RR, Adusumili S, Meiler J, Sanders CR, Mirshahi T, Puckelwartz MJ, McNally EM, George AL. Functional Consequences of Incidentally Discovered KCNQ1 Variants Determined by Automated Electrophysiology Biophysical Journal. 118: 110a. DOI: 10.1016/J.Bpj.2019.11.749  0.226
2017 Li B, Mendenhall JL, Kroncke BM, Taylor KC, Huang H, Smith DK, Vanoye CG, Blume JD, George AL, Sanders CR, Meiler J. Predicting the Functional Impact of KCNQ1 Variants of Unknown Significance. Circulation. Cardiovascular Genetics. 10. PMID 29021305 DOI: 10.1161/Circgenetics.117.001754  0.225
2014 Kumar KK, Lowe EW, Aboud AA, Neely MD, Redha R, Bauer JA, Odak M, Weaver CD, Meiler J, Aschner M, Bowman AB. Cellular manganese content is developmentally regulated in human dopaminergic neurons. Scientific Reports. 4: 6801. PMID 25348053 DOI: 10.1038/Srep06801  0.225
2021 Schmitz S, Ertelt M, Merkl R, Meiler J. Rosetta design with co-evolutionary information retains protein function. Plos Computational Biology. 17: e1008568. PMID 33465067 DOI: 10.1371/journal.pcbi.1008568  0.224
2021 Schmitz S, Ertelt M, Merkl R, Meiler J. Rosetta design with co-evolutionary information retains protein function. Plos Computational Biology. 17: e1008568. PMID 33465067 DOI: 10.1371/journal.pcbi.1008568  0.224
2012 Yang R, Shi J, Byeon IJ, Ahn J, Sheehan JH, Meiler J, Gronenborn AM, Aiken C. Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects. Retrovirology. 9: 30. PMID 22515365 DOI: 10.1186/1742-4690-9-30  0.223
2019 Taylor KC, wei Kang P, Hou P, Yang N, Kuenze G, Shi J, Smith JA, McFarland White K, Huang H, Peng D, George AL, Meiler J, McFeeters RL, Cui J, Sanders CR. Structure of the Intermediate State of the Human KCNQ1 Channel Voltage-Sensor Domain Biophysical Journal. 116: 542a. DOI: 10.1016/J.Bpj.2018.11.2914  0.223
2019 Zhang Y, Brown BP, Westover D, Yan Y, Qiao H, Huang V, Du Z, Smith JA, Ross JS, Miller VA, Ali S, Bazhenova L, Schrock AB, Meiler J, Lovly CM. Abstract 930: On-target resistance to mutant selective EGFR inhibitors develops in an allele-specific manner dependent on the original EGFR activating mutation Cancer Research. 79: 930-930. DOI: 10.1158/1538-7445.Am2019-930  0.222
2011 Henry LK, Iwamoto H, Field JR, Kaufmann K, Dawson ES, Jacobs MT, Adams C, Felts B, Zdravkovic I, Armstrong V, Combs S, Solis E, Rudnick G, Noskov SY, DeFelice LJ, ... Meiler J, et al. A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transport. The Journal of Biological Chemistry. 286: 30823-36. PMID 21730057 DOI: 10.1074/Jbc.M111.250308  0.222
2022 Del Alamo D, Sala D, Mchaourab HS, Meiler J. Sampling alternative conformational states of transporters and receptors with AlphaFold2. Elife. 11. PMID 35238773 DOI: 10.7554/eLife.75751  0.221
2016 Meiler J, Sliwoski G, Schubert M, Stichel J, Beck-Sickinger A, Weaver D. Discovery of novel small-molecule modulators of the human Y4 receptor Neuropeptides. 55: 10. DOI: 10.1016/J.Npep.2015.11.025  0.221
2017 Hanker AB, Red Brewer M, Sheehan JH, Koch JP, Sliwoski GR, Nagy R, Lanman R, Berger MF, Hyman DM, Solit DB, He J, Miller V, Cutler RE, Lalani AS, Cross D, ... ... Meiler J, et al. An Acquired HER2 T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer. Cancer Discovery. PMID 28274957 DOI: 10.1158/2159-8290.Cd-16-1431  0.22
2017 Du Z, Gallant J, Sheehan J, Meiler J, Lovly C. Intramolecular Dimerization of EGFR Kinase Domain Duplication as a Novel Activation Mechanism Journal of Thoracic Oncology. 12: S1536. DOI: 10.1016/J.Jtho.2017.06.022  0.22
2021 Bozhanova NG, Harp JM, Bender BJ, Gavrikov AS, Gorbachev DA, Baranov MS, Mercado CB, Zhang X, Lukyanov KA, Mishin AS, Meiler J. Computational redesign of a fluorogen activating protein with Rosetta. Plos Computational Biology. 17: e1009555. PMID 34748541 DOI: 10.1371/journal.pcbi.1009555  0.22
2020 Del Alamo D, Fischer AW, Moretti R, Alexander NS, Mendenhall J, Hyman NJ, Meiler J. Efficient Sampling of Protein Loop Regions Using Conformational Hashing Complemented with Random Coordinate Descent. Journal of Chemical Theory and Computation. PMID 33373213 DOI: 10.1021/acs.jctc.0c00836  0.219
2020 Del Alamo D, Fischer AW, Moretti R, Alexander NS, Mendenhall J, Hyman NJ, Meiler J. Efficient Sampling of Protein Loop Regions Using Conformational Hashing Complemented with Random Coordinate Descent. Journal of Chemical Theory and Computation. PMID 33373213 DOI: 10.1021/acs.jctc.0c00836  0.219
2015 Kaiser A, Müller P, Zellmann T, Scheidt HA, Thomas L, Bosse M, Meier R, Meiler J, Huster D, Beck-Sickinger AG, Schmidt P. Die Entfaltung der C-terminalen α-Helix des Neuropeptids Y ist entscheidend für die Bindung und Aktivierung des Y2-Rezeptors Angewandte Chemie. 127: 7554-7558. DOI: 10.1002/Ange.201411688  0.218
2020 Taylor KC, Kang PW, Hou P, Yang N, Kuenze G, Smith JA, Shi J, Huang H, White KM, Peng D, George AL, Meiler J, McFeeters RL, Cui J, Sanders CR. Author response: Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state Elife. DOI: 10.7554/Elife.53901.Sa2  0.217
2018 Sánchez-Soto M, Casadó-Anguera V, Yano H, Bender BJ, Cai NS, Moreno E, Canela EI, Cortés A, Meiler J, Casadó V, Ferré S. α- and α-Adrenoceptors as Potential Targets for Dopamine and Dopamine Receptor Ligands. Molecular Neurobiology. PMID 29552726 DOI: 10.1007/S12035-018-1004-1  0.217
2015 Gallant JN, Sheehan JH, Shaver TM, Bailey M, Lipson D, Chandramohan R, Red Brewer M, York SJ, Kris MG, Pietenpol JA, Ladanyi M, Miller VA, Ali SM, Meiler J, Lovly CM. EGFR kinase domain duplication (EGFR-KDD) is a novel oncogenic driver in lung cancer that is clinically responsive to afatinib. Cancer Discovery. PMID 26286086 DOI: 10.1158/2159-8290.Cd-15-0654  0.216
2015 DeLuca S, Khar K, Meiler J. Comparison of specific successes and failures between the RosettaLigand protocols. Plos One. DOI: 10.1371/Journal.Pone.0132508.G007  0.215
2022 Sala D, Del Alamo D, Mchaourab HS, Meiler J. Modeling of protein conformational changes with Rosetta guided by limited experimental data. Structure (London, England : 1993). PMID 35597243 DOI: 10.1016/j.str.2022.04.013  0.215
2020 Sanders CR, Taylor KC, Kang PW, Hou P, Yang N, Kuenze G, George AL, Meiler J, McFeeters RL, Cui J. Structure and Physiological Function of the KCNQ1 Channel Voltage Sensor Intermediate State Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1858  0.214
2018 Mao J, Kuenze G, Joedicke L, Meiler J, Michel H, Glaubitz C. Backbone structure of Des-Arg10-Kallidin (DAKD) peptide in frozen DDM/CHS detergent micelle solution determined by DNP-enhanced MAS SSNMR Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr34208  0.214
2015 Donahue JP, Levinson RT, Sheehan JH, Sutton L, Taylor HE, Meiler J, D'Aquila RT, Song C. Genetic analysis of the localization of APOBEC3F to human immunodeficiency virus type 1 virion cores. Journal of Virology. 89: 2415-24. PMID 25505075 DOI: 10.1128/Jvi.01981-14  0.214
2017 Fischer AW, Anderson DM, Tessmer MH, Frank DW, Feix JB, Meiler J. Structure and Dynamics of Type III Secretion Effector Protein ExoU As determined by SDSL-EPR Spectroscopy in Conjunction with De Novo Protein Folding. Acs Omega. 2: 2977-2984. PMID 28691114 DOI: 10.1021/acsomega.7b00349  0.213
2009 Lebois EP, Bridges TM, Dawson ES, Kennedy JP, Xiang Z, Jadhav SB, Yin H, Meiler J, Jones CK, Conn PJ, Weaver CD, Lindsley CW. P2-256: Towards the treatment of Alzheimer's disease: Discovery and development of novel subtype-specific M1 allosteric agonists Alzheimer's & Dementia. 5: P335-P335. DOI: 10.1016/J.Jalz.2009.04.570  0.212
2019 Hanker A, Koch J, Ye D, Sliwoski G, Sheehan J, Kinch L, Brewer MR, He J, Miller V, Lalani A, Cutler R, Croessmann S, Zabransky D, Meiler J, Arteaga C. Abstract PD3-05: Co-occurring gain-of-function mutations in HER2 and HER3 cooperate to enhance HER2/HER3 binding, HER-dependent signaling, and breast cancer growth Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-Pd3-05  0.212
2020 Brewer KR, Huang H, Kuenze G, Meiler J, Sanders CR. KCNQ1 DDG Calculations and Correlation to Experimental Data Biophysical Journal. 118: 263a. DOI: 10.1016/J.Bpj.2019.11.1522  0.212
2016 Konduri K, Gallant JN, Chae YK, Giles FJ, Gitlitz BJ, Gowen K, Ichihara E, Owonikoko TK, Peddareddigari V, Ramalingam SS, Reddy SK, Eaby-Sandy B, Vavalà T, Whiteley A, Chen H, ... ... Meiler J, et al. EGFR fusions as novel therapeutic targets in lung cancer. Cancer Discovery. PMID 27102076 DOI: 10.1158/2159-8290.Cd-16-0075  0.211
2016 Schubert M, Stichel JD, Sliwosky GR, Gurevich VV, Weaver CD, Meiler J, Beck-Sickinger AG. Allosteric modulators to target the human Y4 receptor Neuropeptides. 55: 18. DOI: 10.1016/J.Npep.2015.11.049  0.211
2020 Bender BJ, Marlow B, Meiler J. Improving homology modeling from low-sequence identity templates in Rosetta: A case study in GPCRs. Plos Computational Biology. 16: e1007597. PMID 33112852 DOI: 10.1371/journal.pcbi.1007597  0.211
2020 Logunova NN, Kriukova VV, Shelyakin PV, Egorov ES, Pereverzeva A, Bozhanova NG, Shugay M, Shcherbinin DS, Pogorelyy MV, Merzlyak EM, Zubov VN, Meiler J, Chudakov DM, Apt AS, Britanova OV. MHC-II alleles shape the CDR3 repertoires of conventional and regulatory naïve CD4 T cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 32482872 DOI: 10.1073/Pnas.2003170117  0.209
2014 Mäde V, Bellmann‐Sickert K, Kaiser A, Meiler J, Beck‐Sickinger AG. Back Cover: Position and Length of Fatty Acids Strongly Affect Receptor Selectivity Pattern of Human Pancreatic Polypeptide Analogues (ChemMedChem 11/2014) Chemmedchem. 9: 2604-2604. DOI: 10.1002/Cmdc.201490043  0.208
2019 Newman JH, Shaver A, Sheehan JH, Mallal S, Stone JH, Pillai S, Bastarache L, Riebau D, Allard-Chamard H, Stone WM, Perugino C, Pilkinton M, Smith SA, McDonnell WJ, Capra JA, ... Meiler J, et al. IgG4-related disease: Association with a rare gene variant expressed in cytotoxic T cells. Molecular Genetics & Genomic Medicine. e686. PMID 30993913 DOI: 10.1002/Mgg3.686  0.206
2022 Phul S, Kuenze G, Vanoye CG, Sanders CR, George AL, Meiler J. Predicting the functional impact of KCNQ1 variants with artificial neural networks. Plos Computational Biology. 18: e1010038. PMID 35442947 DOI: 10.1371/journal.pcbi.1010038  0.206
2018 Fu DY, Meiler J. RosettaLigandEnsemble: A Small-Molecule Ensemble-Driven Docking Approach. Acs Omega. 3: 3655-3664. PMID 29732444 DOI: 10.1021/acsomega.7b02059  0.205
2020 Tilden DR, Sheehan JH, Newman JH, Meiler J, Capra JA, Ramirez A, Simmons J, Dahir K. Phenotypic Profiling in Subjects Heterozygous for 1 of 2 Rare Variants in the Hypophosphatasia Gene (). Journal of the Endocrine Society. 4: bvaa084. PMID 32803091 DOI: 10.1210/Jendso/Bvaa084  0.202
2021 Li B, Mendenhall J, Capra JA, Meiler J. A Multitask Deep-Learning Method for Predicting Membrane Associations and Secondary Structures of Proteins. Journal of Proteome Research. PMID 34236204 DOI: 10.1021/acs.jproteome.1c00410  0.199
2021 Li B, Mendenhall J, Capra JA, Meiler J. A Multitask Deep-Learning Method for Predicting Membrane Associations and Secondary Structures of Proteins. Journal of Proteome Research. PMID 34236204 DOI: 10.1021/acs.jproteome.1c00410  0.199
2023 Liessmann F, Künze G, Meiler J. Improving the Modeling of Extracellular Ligand Binding Pockets in RosettaGPCR for Conformational Selection. International Journal of Molecular Sciences. 24. PMID 37175495 DOI: 10.3390/ijms24097788  0.197
2004 Meiler J, Lefebvre B, Williams A, Hachey M. Addendum to “Using neural networks for 13C NMR chemical shift prediction—comparison with traditional methods” [J. Magn. Reson. 157 (2002) 242–252] Journal of Magnetic Resonance. 171: 1-3. DOI: 10.1016/J.Jmr.2004.07.012  0.197
2016 Tang D, Li J, Buck JR, Tantawy MN, Xia Y, Harp JM, Nickels ML, Meiler J, Manning HC. Evaluation of TSPO PET Ligands [(18)F]VUIIS1009A and [(18)F]VUIIS1009B: Tracers for Cancer Imaging. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. PMID 27853987 DOI: 10.1007/S11307-016-1027-9  0.196
2020 Huang H, Chamness L, Schlebach J, Hadziselimovic A, Kuenze G, Meiler J, George AL, Sanders CR. Stabilization of the KCNQ1 Potassium Channel Causes Disease Biophysical Journal. 118: 108a. DOI: 10.1016/J.Bpj.2019.11.740  0.195
2022 Gulsevin A, Han B, Porta JC, Mchaourab HS, Meiler J, Kenworthy AK. Template-free prediction of a new monotopic membrane protein fold and assembly by Alphafold2. Biophysical Journal. PMID 36352786 DOI: 10.1016/j.bpj.2022.11.011  0.193
2024 Vallat B, Webb BM, Westbrook JD, Goddard TD, Hanke CA, Graziadei A, Peisach E, Zalevsky A, Sagendorf J, Tangmunarunkit H, Voinea S, Sekharan M, Yu J, A M J J Bonvin A, DiMaio F, ... ... Meiler J, et al. IHMCIF: An Extension of the PDBx/mmCIF Data Standard for Integrative Structure Determination Methods. Journal of Molecular Biology. 168546. PMID 38508301 DOI: 10.1016/j.jmb.2024.168546  0.192
2017 Hanker A, Brewer MR, Sheehan J, Koch J, Lanman R, Hyman D, Cutler R, Lalani A, Cross D, Lovly C, Meiler J, Arteaga C. Abstract P3-03-03: An acquired HER2 T798I gatekeeper mutation induces resistance to neratinib in a patient with HER2 mutant-driven breast cancer Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-P3-03-03  0.19
2021 Brown BP, Mendenhall J, Geanes AR, Meiler J. General Purpose Structure-Based Drug Discovery Neural Network Score Functions with Human-Interpretable Pharmacophore Maps. Journal of Chemical Information and Modeling. PMID 33496578 DOI: 10.1021/acs.jcim.0c01001  0.189
2019 Hanker AB, Brewer MR, Sheehan JH, Koch JP, Sliwoski GR, Nagy R, Lanman R, Berger MF, Hyman DM, Solit DB, He J, Miller V, Cutler RE, Lalani AS, Cross D, ... ... Meiler J, et al. Correction: An Acquired Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer. Cancer Discovery. 9: 303. PMID 30737217 DOI: 10.1158/2159-8290.Cd-18-1515  0.189
2019 Shibao CA, Phillips J, Cogan JD, Newman JH, Hamid R, Meiler J, Capra JA, Sheehan J, Yan Y, Vetrini F, Black B, Joos K, Robertson D, Biaggioni I. Abstract P176: Familial Autonomic Ganglionopathy Caused by Rare CHRNA3 Genetic Variants. Novel Genetic Cause of Neurogenic Orthostatic Hypotension Hypertension. 74. DOI: 10.1161/Hyp.74.Suppl_1.P176  0.189
2022 Fischer MFS, Crowe JE, Meiler J. Computational epitope mapping of class I fusion proteins using low complexity supervised learning methods. Plos Computational Biology. 18: e1010230. PMID 36477260 DOI: 10.1371/journal.pcbi.1010230  0.186
2009 Koehler J, Mueller R, Meiler J. Improved prediction of trans-membrane spans in proteins using an Artificial Neural Network. Ieee Symposium On Computational Intelligence in Bioinformatics and Computational Biology Proceedings . Ieee Symposium On Computational Intelligence in Bioinformatics and Computational Biology. 2009: 68-74. PMID 27747315 DOI: 10.1109/CIBCB.2009.4925709  0.186
2020 Tessmer MH, DeCero SA, Del Alamo D, Riegert MO, Meiler J, Frank DW, Feix JB. Characterization of the ExoU activation mechanism using EPR and integrative modeling. Scientific Reports. 10: 19700. PMID 33184362 DOI: 10.1038/s41598-020-76023-3  0.186
2022 Nagel M, Moretti R, Paschke R, von Bergen M, Meiler J, Kalkhof S. Integrative model of the FSH receptor reveals the structural role of the flexible hinge region. Structure (London, England : 1993). PMID 35973423 DOI: 10.1016/j.str.2022.07.007  0.186
2021 Fischer TF, Schoeder CT, Zellmann T, Stichel J, Meiler J, Beck-Sickinger AG. Cyclic Analogues of the Chemerin C-Terminus Mimic a Loop Conformation Essential for Activating the Chemokine-like Receptor 1. Journal of Medicinal Chemistry. PMID 33705662 DOI: 10.1021/acs.jmedchem.0c01804  0.183
2020 Smith ST, Meiler J. Assessing multiple score functions in Rosetta for drug discovery. Plos One. 15: e0240450. PMID 33044994 DOI: 10.1371/journal.pone.0240450  0.181
2024 Harmych SJ, Tydings CW, Meiler J, Singh B. Sequence and structural insights of monoleucine-based sorting motifs contained within the cytoplasmic domains of basolateral proteins. Frontiers in Cell and Developmental Biology. 12: 1379224. PMID 38495621 DOI: 10.3389/fcell.2024.1379224  0.18
2022 Gonzalez Somermeyer L, Fleiss A, Mishin AS, Bozhanova NG, Igolkina AA, Meiler J, Alaball Pujol ME, Putintseva EV, Sarkisyan KS, Kondrashov FA. Heterogeneity of the GFP fitness landscape and data-driven protein design. Elife. 11. PMID 35510622 DOI: 10.7554/eLife.75842  0.179
2022 McDonald EF, Jones T, Plate L, Meiler J, Gulsevin A. Benchmarking AlphaFold2 on peptide structure prediction. Structure (London, England : 1993). 31: 111-119.e2. PMID 36525975 DOI: 10.1016/j.str.2022.11.012  0.177
2023 Schüß C, Vu O, Mishra NM, Tough IR, Du Y, Stichel J, Cox HM, Weaver CD, Meiler J, Emmitte KA, Beck-Sickinger AG. Structure-Activity Relationship Study of the High-Affinity Neuropeptide Y Receptor Positive Allosteric Modulator VU0506013. Journal of Medicinal Chemistry. PMID 37339079 DOI: 10.1021/acs.jmedchem.3c00383  0.177
2021 Del Alamo D, Jagessar KL, Meiler J, Mchaourab HS. Methodology for rigorous modeling of protein conformational changes by Rosetta using DEER distance restraints. Plos Computational Biology. 17: e1009107. PMID 34133419 DOI: 10.1371/journal.pcbi.1009107  0.175
2023 Marlow B, Kuenze G, Meiler J, Koehler Leman J. Docking cholesterol to integral membrane proteins with Rosetta. Plos Computational Biology. 19: e1010947. PMID 36972273 DOI: 10.1371/journal.pcbi.1010947  0.173
2022 Kuntz CP, Woods H, McKee AG, Zelt NB, Mendenhall JL, Meiler J, Schlebach JP. Towards generalizable predictions for G protein-coupled receptor variant expression. Biophysical Journal. PMID 35715957 DOI: 10.1016/j.bpj.2022.06.018  0.17
2022 Tran MH, Schoeder CT, Schey KL, Meiler J. Computational Structure Prediction for Antibody-Antigen Complexes From Hydrogen-Deuterium Exchange Mass Spectrometry: Challenges and Outlook. Frontiers in Immunology. 13: 859964. PMID 35720345 DOI: 10.3389/fimmu.2022.859964  0.167
2023 Selvasingh JA, McDonald EF, Neufer PD, McKinney JR, Meiler J, Ledwitch KV. Dark nanodiscs for evaluating membrane protein thermostability by differential scanning fluorimetry. Biophysical Journal. PMID 37978799 DOI: 10.1016/j.bpj.2023.11.019  0.165
2023 Woods H, Schiano DL, Aguirre JI, Ledwitch KV, McDonald EF, Voehler M, Meiler J, Schoeder CT. Computational modeling and prediction of deletion mutants. Structure (London, England : 1993). PMID 37119820 DOI: 10.1016/j.str.2023.04.005  0.164
2022 Smith ST, Shub L, Meiler J. PlaceWaters: Real-time, explicit interface water sampling during Rosetta ligand docking. Plos One. 17: e0269072. PMID 35639743 DOI: 10.1371/journal.pone.0269072  0.164
2020 Bozhanova NG, Calcutt MW, Beavers WN, Brown BP, Skaar EP, Meiler J. Lipocalin Blc is a potential heme-binding protein. Febs Letters. PMID 33210733 DOI: 10.1002/1873-3468.14001  0.164
2023 Selvasingh JA, McDonald EF, Mckinney JR, Meiler J, Ledwitch KV. Dark nanodiscs as a model membrane for evaluating membrane protein thermostability by differential scanning fluorimetry. Biorxiv : the Preprint Server For Biology. PMID 37214798 DOI: 10.1101/2023.05.08.539917  0.163
2024 Brown BP, Stein RA, Meiler J, Mchaourab HS. Approximating Projections of Conformational Boltzmann Distributions with AlphaFold2 Predictions: Opportunities and Limitations. Journal of Chemical Theory and Computation. PMID 38215214 DOI: 10.1021/acs.jctc.3c01081  0.162
2021 Marlow B, Kuenze G, Li B, Sanders CR, Meiler J. Structural Determinants of Cholesterol Recognition in Helical Integral Membrane Proteins. Biophysical Journal. PMID 33640379 DOI: 10.1016/j.bpj.2021.02.028  0.159
2022 McDonald EF, Woods H, Smith ST, Kim M, Schoeder CT, Plate L, Meiler J. Structural Comparative Modeling of Multi-Domain F508del CFTR. Biomolecules. 12. PMID 35327663 DOI: 10.3390/biom12030471  0.157
2020 Mendenhall J, Brown BP, Kothiwale S, Meiler J. BCL::Conf: Improved Open-Source Knowledge-Based Conformation Sampling Using the Crystallography Open Database. Journal of Chemical Information and Modeling. PMID 33351632 DOI: 10.1021/acs.jcim.0c01140  0.157
2023 Liu YL, Moretti R, Wang Y, Bodenheimer B, Derr T, Meiler J. Integrating Expert Knowledge with Deep Learning Improves QSAR Models for CADD Modeling. Biorxiv : the Preprint Server For Biology. PMID 37131837 DOI: 10.1101/2023.04.17.537185  0.156
2016 Kölbel K, Warnke S, Seo J, von Helden G, Moretti R, Meiler J, Pagel K, Sinz A. Conformational Shift of a β-Hairpin Peptide upon Complex Formation with an Oligo-proline Peptide Studied by Mass Spectrometry. Chemistryselect. 1: 3651-3656. PMID 30547079 DOI: 10.1002/slct.201600934  0.152
2021 Kodali P, Schoeder CT, Schmitz S, Crowe JE, Meiler J. RosettaCM for antibodies with very long HCDR3s and low template availability. Proteins. PMID 34176159 DOI: 10.1002/prot.26166  0.151
2021 Kodali P, Schoeder CT, Schmitz S, Crowe JE, Meiler J. RosettaCM for antibodies with very long HCDR3s and low template availability. Proteins. PMID 34176159 DOI: 10.1002/prot.26166  0.151
2022 Del Alamo D, Meiler J, Mchaourab HS. Principles of Alternating Access in LeuT-fold Transporters: Commonalities and Divergences. Journal of Molecular Biology. 434: 167746. PMID 35843285 DOI: 10.1016/j.jmb.2022.167746  0.15
2023 Han B, Gulsevin A, Connolly S, Wang T, Meyer B, Porta J, Tiwari A, Deng A, Chang L, Peskova Y, Mchaoraub H, Karakas E, Ohi M, Meiler J, Kenworthy A. Structural analysis of the P132L disease mutation in caveolin-1 reveals its role in assembly of oligomeric complexes. The Journal of Biological Chemistry. 104574. PMID 36870682 DOI: 10.1016/j.jbc.2023.104574  0.15
2023 Brown BP, Stein RA, Meiler J, Mchaourab H. Approximating conformational Boltzmann distributions with AlphaFold2 predictions. Biorxiv : the Preprint Server For Biology. PMID 37609301 DOI: 10.1101/2023.08.06.552168  0.15
2022 Mukherjee S, Cassini TA, Hu N, Yang T, Li B, Shen W, Moth CW, Rinker DC, Sheehan JH, Cogan JD, Newman JH, Hamid R, Macdonald RL, Roden DM, Meiler J, et al. Personalized structural biology reveals the molecular mechanisms underlying heterogeneous epileptic phenotypes caused by KCNC2 variants. Hgg Advances. 3: 100131. PMID 36035247 DOI: 10.1016/j.xhgg.2022.100131  0.149
2021 Gulsevin A, Meiler J. Prediction of amphipathic helix-Membrane interactions with Rosetta. Plos Computational Biology. 17: e1008818. PMID 33730029 DOI: 10.1371/journal.pcbi.1008818  0.148
2023 Chamness LM, Kuntz CP, McKee AG, Penn WD, Hemmerich CM, Rusch DB, Woods H, Meiler J, Schlebach JP. Divergent Pairwise Epistasis in the Context of Unstable Membrane Protein Variants. Biorxiv : the Preprint Server For Biology. PMID 37662415 DOI: 10.1101/2023.08.25.554866  0.147
2024 Philipp M, Moth CW, Ristic N, Tiemann JKS, Seufert F, Panfilova A, Meiler J, Hildebrand PW, Stein A, Wiegreffe D, Staritzbichler R. MUTATIONEXPLORER- A WEBSERVER FOR MUTATION OF PROTEINS AND 3D VISUALIZATION OF ENERGETIC IMPACTS. Biorxiv : the Preprint Server For Biology. PMID 38464310 DOI: 10.1101/2023.03.23.533926  0.147
2021 Schüß C, Vu O, Schubert M, Du Y, Mishra NM, Tough IR, Stichel J, Weaver CD, Emmitte KA, Cox HM, Meiler J, Beck-Sickinger AG. Highly Selective Y Receptor Antagonist Binds in an Allosteric Binding Pocket. Journal of Medicinal Chemistry. PMID 33595306 DOI: 10.1021/acs.jmedchem.0c02000  0.144
2020 Gulsevin A, Meiler J, Horenstein NA. A Computational Analysis of the Factors Governing the Dynamics of α7 nAChR and Its Homologs. Biophysical Journal. PMID 33010233 DOI: 10.1016/j.bpj.2020.09.006  0.142
2020 Bozhanova NG, Sangha AK, Sevy AM, Gilchuk P, Huang K, Nargi RS, Reidy JX, Trivette A, Carnahan RH, Bukreyev A, Crowe JE, Meiler J. Discovery of Marburg virus neutralizing antibodies from virus-naïve human antibody repertoires using large-scale structural predictions. Proceedings of the National Academy of Sciences of the United States of America. PMID 33229516 DOI: 10.1073/pnas.1922654117  0.142
2023 Junker H, Meiler J, Schoeder CT. Interplay of thermodynamics and evolution within the ternary ligand-GPCR-G protein complex. Current Opinion in Structural Biology. 82: 102656. PMID 37467526 DOI: 10.1016/j.sbi.2023.102656  0.142
2022 Bloodworth N, Barbaro NR, Moretti R, Harrison DG, Meiler J. Rosetta FlexPepDock to predict peptide-MHC binding: An approach for non-canonical amino acids. Plos One. 17: e0275759. PMID 36512534 DOI: 10.1371/journal.pone.0275759  0.141
2022 Del Alamo D, DeSousa L, Nair RM, Rahman S, Meiler J, Mchaourab HS. Integrated AlphaFold2 and DEER investigation of the conformational dynamics of a pH-dependent APC antiporter. Proceedings of the National Academy of Sciences of the United States of America. 119: e2206129119. PMID 35969794 DOI: 10.1073/pnas.2206129119  0.138
2021 Chamness LM, Zelt NB, Harrington HR, Kuntz CP, Bender BJ, Penn WD, Ziarek JJ, Meiler J, Schlebach JP. Molecular basis for the evolved instability of a human G-protein coupled receptor. Cell Reports. 37: 110046. PMID 34818554 DOI: 10.1016/j.celrep.2021.110046  0.138
2021 Vu O, Bender BJ, Pankewitz L, Huster D, Beck-Sickinger AG, Meiler J. The Structural Basis of Peptide Binding at Class A G Protein-Coupled Receptors. Molecules (Basel, Switzerland). 27. PMID 35011444 DOI: 10.3390/molecules27010210  0.136
2024 McDonald EF, Oliver KE, Schlebach JP, Meiler J, Plate L. Benchmarking AlphaMissense pathogenicity predictions against cystic fibrosis variants. Plos One. 19: e0297560. PMID 38271453 DOI: 10.1371/journal.pone.0297560  0.134
2022 Brown BP, Vu O, Geanes AR, Kothiwale S, Butkiewicz M, Lowe EW, Mueller R, Pape R, Mendenhall J, Meiler J. Introduction to the BioChemical Library (BCL): An Application-Based Open-Source Toolkit for Integrated Cheminformatics and Machine Learning in Computer-Aided Drug Discovery. Frontiers in Pharmacology. 13: 833099. PMID 35264967 DOI: 10.3389/fphar.2022.833099  0.13
2002 Meiler J, Sanli E, Junker J, Meusinger R, Lindel T, Will M, Maier W, Köck M. Validation of structural proposals by substructure analysis and 13C NMR chemical shift prediction. Journal of Chemical Information and Computer Sciences. 42: 241-8. PMID 11911693 DOI: 10.1021/ci010294n  0.129
2021 Rudolf S, Kaempf K, Vu O, Meiler J, Beck-Sickinger AG, Coin I. Binding of Natural Peptide Ligands to the Neuropeptide Y5 Receptor. Angewandte Chemie (International Ed. in English). PMID 34822209 DOI: 10.1002/anie.202108738  0.127
2017 Butkiewicz M, Wang Y, Bryant SH, Lowe EW, Weaver DC, Meiler J. High-Throughput Screening Assay Datasets from the PubChem Database. Chemical Informatics (Wilmington, Del.). 3. PMID 29795804  0.127
2022 Zimmermann A, Vu O, Brüser A, Sliwoski G, Marnett LJ, Meiler J, Schöneberg T. Mapping the binding sites of UDP and prostaglandin E2 glyceryl ester in the nucleotide receptor P2Y6. Chemmedchem. PMID 35034430 DOI: 10.1002/cmdc.202100683  0.125
2021 Fischer TF, Czerniak AS, Weiß T, Schoeder CT, Wolf P, Seitz O, Meiler J, Beck-Sickinger AG. Ligand-binding and -scavenging of the chemerin receptor GPR1. Cellular and Molecular Life Sciences : Cmls. PMID 34241650 DOI: 10.1007/s00018-021-03894-8  0.124
2023 McDonald EF, Oliver KE, Schlebach JP, Meiler J, Plate L. Benchmarking AlphaMissense Pathogenicity Predictions Against Cystic Fibrosis Variants. Biorxiv : the Preprint Server For Biology. PMID 37873426 DOI: 10.1101/2023.10.05.561147  0.121
2011 Alexander N, Woetzel N, Meiler J. bcl::Cluster : A method for clustering biological molecules coupled with visualization in the Pymol Molecular Graphics System. Ieee ... International Conference On Computational Advances in Bio and Medical Sciences : [Proceedings]. Ieee International Conference On Computational Advances in Bio and Medical Sciences. 2011: 13-18. PMID 27818847 DOI: 10.1109/ICCABS.2011.5729867  0.121
2011 Alexander N, Woetzel N, Meiler J. bcl::Cluster : A method for clustering biological molecules coupled with visualization in the Pymol Molecular Graphics System. Ieee ... International Conference On Computational Advances in Bio and Medical Sciences : [Proceedings]. Ieee International Conference On Computational Advances in Bio and Medical Sciences. 2011: 13-18. PMID 27818847 DOI: 10.1109/ICCABS.2011.5729867  0.121
2021 Mikhailowitsch Gershkovich M, Elisabeth Groß V, Vu O, Tabea Schoeder C, Meiler J, Prömel S, Kaiser A. Structural perspective on ancient neuropeptide Y -like system reveals hallmark features for peptide recognition and receptor activation. Journal of Molecular Biology. 166992. PMID 33865871 DOI: 10.1016/j.jmb.2021.166992  0.121
2024 Smith ST, Cassada JB, Von Bredow L, Erreger K, Webb EM, Trombley TA, Kalbfleisch JJ, Bender BJ, Zagol-Ikapitte I, Kramlinger VM, Bouchard JL, Mitchell SG, Tretbar M, Shoichet BK, Lindsley CW, ... Meiler J, et al. Discovery of Protease-Activated Receptor 4 (PAR4)-Tethered Ligand Antagonists Using Ultralarge Virtual Screening. Acs Pharmacology & Translational Science. 7: 1086-1100. PMID 38633591 DOI: 10.1021/acsptsci.3c00378  0.12
2024 Ertelt M, Meiler J, Schoeder CT. Combining Rosetta Sequence Design with Protein Language Model Predictions Using Evolutionary Scale Modeling (ESM) as Restraint. Acs Synthetic Biology. 13: 1085-1092. PMID 38568188 DOI: 10.1021/acssynbio.3c00753  0.12
2024 Moeller J, Bozhanova NG, Voehler M, Meiler J, Schoeder CT. Backbone chemical shift and secondary structure assignments for mouse siderocalin. Biomolecular Nmr Assignments. PMID 38564159 DOI: 10.1007/s12104-024-10171-9  0.12
2024 Tang Y, Moretti R, Meiler J. Recent Advances in Automated Structure-Based De Novo Drug Design. Journal of Chemical Information and Modeling. 64: 1794-1805. PMID 38485516 DOI: 10.1021/acs.jcim.4c00247  0.12
2022 Schmitz S, Schmitz EA, Crowe JE, Meiler J. The human antibody sequence space and structural design of the V, J regions, and CDRH3 with Rosetta. Mabs. 14: 2068212. PMID 35544469 DOI: 10.1080/19420862.2022.2068212  0.116
2022 Porta JC, Han B, Gulsevin A, Chung JM, Peskova Y, Connolly S, Mchaourab HS, Meiler J, Karakas E, Kenworthy AK, Ohi MD. Molecular architecture of the human caveolin-1 complex. Science Advances. 8: eabn7232. PMID 35544577 DOI: 10.1126/sciadv.abn7232  0.116
2002 Meiler J, Meringer M. Ranking Molgen structure proposals by 13C NMR chemical shift prediction with analyze Match. 85-108.  0.114
2020 Kuenze G, Vanoye CG, Desai RR, Adusumilli S, Brewer KR, Woods H, McDonald EF, Sanders CR, George AL, Meiler J. Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation. Elife. 9. PMID 33095155 DOI: 10.7554/eLife.57680  0.113
2023 McDonald EF, Meiler J, Plate L. CFTR Folding: From Structure and Proteostasis to Cystic Fibrosis Personalized Medicine. Acs Chemical Biology. 18: 2128-2143. PMID 37730207 DOI: 10.1021/acschembio.3c00310  0.109
2021 Du Z, Brown BP, Kim S, Ferguson D, Pavlick DC, Jayakumaran G, Benayed R, Gallant JN, Zhang YK, Yan Y, Red-Brewer M, Ali SM, Schrock AB, Zehir A, Ladanyi M, ... ... Meiler J, et al. Structure-function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting. Nature Communications. 12: 1382. PMID 33654076 DOI: 10.1038/s41467-021-21613-6  0.108
2022 Gulsevin A, Glazer AM, Shields T, Kroncke BM, Roden DM, Meiler J. Veratridine Can Bind to a Site at the Mouth of the Channel Pore at Human Cardiac Sodium Channel Na1.5. International Journal of Molecular Sciences. 23. PMID 35216338 DOI: 10.3390/ijms23042225  0.108
2021 Maddur AA, Voehler M, Panizzi P, Meiler J, Bock PE, Verhamme IM. Mapping of the fibrinogen-binding site on the staphylocoagulase C-terminal repeat region. The Journal of Biological Chemistry. 101493. PMID 34915025 DOI: 10.1016/j.jbc.2021.101493  0.105
2021 Williamson LE, Reeder KM, Bailey K, Tran MH, Roy V, Fouch ME, Kose N, Trivette A, Nargi RS, Winkler ES, Kim AS, Gainza C, Rodriguez J, Armstrong E, Sutton RE, ... ... Meiler J, et al. Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress. Cell. 184: 4430-4446.e22. PMID 34416147 DOI: 10.1016/j.cell.2021.07.033  0.104
2022 Bozhanova NG, Flyak AI, Brown BP, Ruiz SE, Salas J, Rho S, Bombardi RG, Myers L, Soto C, Bailey JR, Crowe JE, Bjorkman PJ, Meiler J. Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals. Nature Communications. 13: 3178. PMID 35676279 DOI: 10.1038/s41467-022-30865-9  0.104
2023 Engdahl TB, Binshtein E, Brocato RL, Kuzmina NA, Principe LM, Kwilas SA, Kim RK, Chapman NS, Porter MS, Guardado-Calvo P, Rey FA, Handal LS, Diaz SM, Zagol-Ikapitte IA, Tran MH, ... ... Meiler J, et al. Antigenic mapping and functional characterization of human new world hantavirus neutralizing antibodies. Elife. 12. PMID 36971354 DOI: 10.7554/eLife.81743  0.104
2024 Küry S, Stanton JE, van Woerden G, Hsieh TC, Rosenfelt C, Scott-Boyer MP, Most V, Wang T, Papendorf JJ, de Konink C, Deb W, Vignard V, Studencka-Turski M, Besnard T, Hajdukowicz AM, ... ... Meiler J, et al. Unveiling the crucial neuronal role of the proteasomal ATPase subunit gene in neurodevelopmental proteasomopathies. Medrxiv : the Preprint Server For Health Sciences. PMID 38293138 DOI: 10.1101/2024.01.13.24301174  0.103
2023 Shi X, Lingerak R, Herting CJ, Ge Y, Kim S, Toth P, Wang W, Brown BP, Meiler J, Sossey-Alaoui K, Buck M, Himanen J, Hambardzumyan D, Nikolov DB, Smith AW, et al. Time-resolved live-cell spectroscopy reveals EphA2 multimeric assembly. Science (New York, N.Y.). eadg5314. PMID 37972196 DOI: 10.1126/science.adg5314  0.103
2022 Blee AM, Li B, Pecen T, Meiler J, Nagel ZD, Capra JA, Chazin WJ. An active learning framework improves tumor variant interpretation. Cancer Research. PMID 35687855 DOI: 10.1158/0008-5472.CAN-21-3798  0.102
2009 Koehler J, Mueller R, Meiler J. Improved prediction of trans-membrane spans in proteins using an artificial neural network 2009 Ieee Symposium On Computational Intelligence in Bioinformatics and Computational Biology, Cibcb 2009 - Proceedings. 68-74. DOI: 10.1109/CIBCB.2009.4925709  0.101
2022 Brown BP, Zhang YK, Kim S, Finneran P, Yan Y, Du Z, Kim J, Hartzler AL, LeNoue-Newton ML, Smith AW, Meiler J, Lovly CM. Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 119: e2206588119. PMID 35867821 DOI: 10.1073/pnas.2206588119  0.101
2012 Lowe EW, Butkiewicz M, White Z, Spellings M, Omlor A, Meiler J. Comparative analysis of machine learning techniques for the prediction of the DMPK parameters intrinsic clearance and plasma protein binding 4th International Conference On Bioinformatics and Computational Biology 2012, Bicob 2012. 25-30.  0.1
2021 McKee AG, Kuntz CP, Ortega JT, Woods H, Most V, Roushar FJ, Meiler J, Jastrzebska B, Schlebach JP. Systematic Profiling of Temperature- and Retinal-Sensitive Rhodopsin Variants by Deep Mutational Scanning. The Journal of Biological Chemistry. 101359. PMID 34756884 DOI: 10.1016/j.jbc.2021.101359  0.099
2022 Nebe M, Kehr S, Schmitz S, Breitfeld J, Lorenz J, Le Duc D, Stadler PF, Meiler J, Kiess W, Garten A, Kirstein AS. Small integral membrane protein 10 like 1 downregulation enhances differentiation of adipose progenitor cells. Biochemical and Biophysical Research Communications. 604: 57-62. PMID 35290761 DOI: 10.1016/j.bbrc.2022.03.014  0.098
2023 McKee AG, McDonald EF, Penn WD, Kuntz CP, Noguera K, Chamness LM, Roushar FJ, Meiler J, Oliver KE, Plate L, Schlebach JP. General trends in the effects of VX-661 and VX-445 on the plasma membrane expression of clinical CFTR variants. Cell Chemical Biology. PMID 37253358 DOI: 10.1016/j.chembiol.2023.05.001  0.097
2007 McKinney BA, Kallewaard NL, Crowe JE, Meiler J. Using the natural evolution of a rotavirus-specific human monoclonal antibody to predict the complex topography of a viral antigenic site Immunome Research. 3. DOI: 10.1186/1745-7580-3-8  0.096
2001 Hlubek F, Löhberg C, Meiler J, Jung A, Kirchner T, Brabletz T. Tip60 is a cell-type-specific transcriptional regulator Journal of Biochemistry. 129: 635-641. PMID 11275565  0.094
2021 Chen Z, Kuenze G, Meiler J, Canessa CM. An arginine residue in the outer segment of hASIC1a TM1 affects both proton affinity and channel desensitization. The Journal of General Physiology. 153. PMID 33851970 DOI: 10.1085/jgp.202012802  0.093
2021 Hanker AB, Brown BP, Meiler J, Marín A, Jayanthan HS, Ye D, Lin CC, Akamatsu H, Lee KM, Chatterjee S, Sudhan DR, Servetto A, Brewer MR, Koch JP, Sheehan JH, et al. Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity. Cancer Cell. PMID 34171264 DOI: 10.1016/j.ccell.2021.06.001  0.092
2021 Bertron JL, Duvernay MT, Mitchell SG, Smith ST, Maeng JG, Blobaum AL, Davis DC, Meiler J, Hamm HE, Lindsley CW. Discovery and Optimization of a Novel Series of Competitive and Central Nervous System-Penetrant Protease-Activated Receptor 4 (PAR4) Inhibitors. Acs Chemical Neuroscience. PMID 34855359 DOI: 10.1021/acschemneuro.1c00557  0.092
2022 Roushar FJ, McKee AG, Kuntz CP, Ortega JT, Penn WD, Woods H, Chamness LM, Most V, Meiler J, Jastrzebska B, Schlebach JP. Molecular Basis for Variations in the Sensitivity of Pathogenic Rhodopsin Variants to 9-cis-Retinal. The Journal of Biological Chemistry. 102266. PMID 35850308 DOI: 10.1016/j.jbc.2022.102266  0.091
2020 Alexander MR, Schoeder CT, Brown JA, Smart CD, Moth C, Wikswo JP, Capra JA, Meiler J, Chen W, Madhur MS. Predicting susceptibility to SARS-CoV-2 infection based on structural differences in ACE2 across species. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 33015868 DOI: 10.1096/fj.202001808R  0.088
2021 Huang H, Chamness LM, Vanoye CG, Kuenze G, Meiler J, George AL, Schlebach JP, Sanders CR. Disease-linked super-trafficking of a potassium channel. The Journal of Biological Chemistry. 100423. PMID 33600800 DOI: 10.1016/j.jbc.2021.100423  0.087
2021 Shibao C, Joos K, Phillips JA, Cogan J, Newman JH, Hamid R, Meiler J, Capra J, Sheehan J, Vetrini F, Yang Y, Black B, Diedrich A, Roberston D, Biaggioni I. Familial Autonomic Ganglionopathy Caused by Rare Genetic Variants. Neurology. PMID 33947782 DOI: 10.1212/WNL.0000000000012143  0.087
2024 Kraft FB, Enns J, Honin I, Engelhardt J, Schöler A, Smith ST, Meiler J, Schäker-Hübner L, Weindl G, Hansen FK. Groebke Blackburn Bienaymé-mediated multi-component synthesis of selective HDAC6 inhibitors with anti-inflammatory properties. Bioorganic Chemistry. 143: 107072. PMID 38185013 DOI: 10.1016/j.bioorg.2023.107072  0.086
2023 Manoharan J, Rana R, Kuenze G, Gupta D, Elwakiel A, Ambreen S, Wang H, Banerjee K, Zimmermann S, Singh K, Gupta A, Fatima S, Kretschmer S, Schaefer L, Zeng-Brouwers J, ... ... Meiler J, et al. Tissue factor binds to and inhibits interferon-α receptor 1 signaling. Immunity. PMID 38141610 DOI: 10.1016/j.immuni.2023.11.017  0.086
2022 Schäker-Hübner L, Haschemi R, Büch T, Kraft FB, Brumme B, Schöler A, Jenke R, Meiler J, Aigner A, Bendas G, Hansen FK. Balancing Histone Deacetylase (HDAC) Inhibition and Drug-likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors. Chemmedchem. PMID 35073610 DOI: 10.1002/cmdc.202100755  0.086
2021 Neuser S, Brechmann B, Heimer G, Brösse I, Schubert S, O'Grady L, Zech M, Srivastava S, Sweetser DA, Dincer Y, Mall V, Winkelmann J, Behrends C, Darras BT, Graham RJ, ... ... Meiler J, et al. Clinical, neuroimaging and molecular spectrum of TECPR2-associated hereditary sensory and autonomic neuropathy with intellectual disability. Human Mutation. PMID 33847017 DOI: 10.1002/humu.24206  0.082
2021 Gulsevin A, Papke RL, Stokes C, Tran HNT, Jin AH, Vetter I, Meiler J. The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site. Toxins. 13. PMID 34437426 DOI: 10.3390/toxins13080555  0.077
2021 Mukherjee S, Cogan JD, Newman JH, Phillips JA, Hamid R, Meiler J, Capra JA. Identifying digenic disease genes via machine learning in the Undiagnosed Diseases Network. American Journal of Human Genetics. PMID 34529933 DOI: 10.1016/j.ajhg.2021.08.010  0.076
2007 Henry LK, Meiler J, Blakely RD. Bound to be different: neurotransmitter transporters meet their bacterial cousins. Molecular Interventions. 7: 306-9. PMID 18199851 DOI: 10.1124/mi.7.6.4  0.075
2018 Vanoye CG, Desai RR, Fabre KL, Gallagher SL, Potet F, DeKeyser JM, Macaya D, Meiler J, Sanders CR, George AL. High-Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance. Circulation. Genomic and Precision Medicine. 11: e002345. PMID 30571187 DOI: 10.1161/CIRCGEN.118.002345  0.074
1989 Meiler J. Simplified determination of the effective prefiltration of an x-ray tube | VEREINFACHTE BESTIMMUNG DES EFFEKTIVEN VORFILTERS VON RONTGENSTRAHLERN Rontgen-Blatter. 42: 487-490. PMID 2685980  0.073
1976 Meiler J. [The effect of increased performance of modern x-ray tubes on improvements in picture quality, particularly of moving organs (author's transl)]. Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin. 125: 70-8. PMID 133950 DOI: 10.1055/s-0029-1230421  0.072
2022 Aslanoglou D, Bertera S, Friggeri L, Sánchez-Soto M, Lee J, Xue X, Logan RW, Lane JR, Yechoor VK, McCormick PJ, Meiler J, Free RB, Sibley DR, Bottino R, Freyberg Z. Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine. Iscience. 25: 104771. PMID 35982797 DOI: 10.1016/j.isci.2022.104771  0.069
2009 Butkiewicz M, Mueller R, Selic D, Dawson E, Meiler J. Application of machine learning approaches on quantitative structure activity relationships 2009 Ieee Symposium On Computational Intelligence in Bioinformatics and Computational Biology, Cibcb 2009 - Proceedings. 255-262. DOI: 10.1109/CIBCB.2009.4925736  0.069
2012 Meiler J, Guyot M, Hoffarth S, Wesarg E, Höhn Y, Breitenbuecher F, Schuler M. Individual dose and scheduling determine the efficacy of combining cytotoxic anticancer agents with a kinase inhibitor in non-small-cell lung cancer. Journal of Cancer Research and Clinical Oncology. 138: 1385-94. PMID 22488173 DOI: 10.1007/s00432-012-1220-4  0.069
2024 Arias HR, Rudin D, Hines DJ, Contreras A, Gulsevin A, Manetti D, Anouar Y, De Deurwaerdere P, Meiler J, Romanelli MN, Liechti ME, Chagraoui A. The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT receptor activation. European Journal of Pharmacology. 966: 176329. PMID 38253116 DOI: 10.1016/j.ejphar.2024.176329  0.068
2021 Aguilar JI, Cheng MH, Font J, Schwartz AC, Ledwitch K, Duran A, Mabry SJ, Belovich AN, Zhu Y, Carter AM, Shi L, Kurian MA, Fenollar-Ferrer C, Meiler J, Ryan RM, et al. Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia. Elife. 10. PMID 34002696 DOI: 10.7554/eLife.68039  0.065
2019 Croessmann S, Sheehan JH, Lee KM, Sliwoski G, He J, Nagy R, Riddle D, Mayer IA, Balko JM, Lanman R, Miller VA, Cantley LC, Meiler J, Arteaga CL. Correction: C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 25: 1432. PMID 30770491 DOI: 10.1158/1078-0432.CCR-18-4269  0.063
2008 Kaufmann KW, Meiler J. Small molecules as rotamers: Generation and docking in ROSETTALIGAND Proceedings of the German Conference On Bioinformatics, Gcb 2008. 148-157.  0.062
2012 Lowe EW, Butkiewicz M, Woetzel N, Meiler J. GPU-accelerated machine learning techniques enable QSAR modeling of large HTS data 2012 Ieee Symposium On Computational Intelligence and Computational Biology, Cibcb 2012. 314-320. DOI: 10.1109/CIBCB.2012.6217246  0.062
2013 Wiesweg M, Ting S, Reis H, Worm K, Kasper S, Tewes M, Welt A, Richly H, Meiler J, Bauer S, Hense J, Gauler TC, Köhler J, Eberhardt WE, Darwiche K, et al. Feasibility of preemptive biomarker profiling for personalised early clinical drug development at a Comprehensive Cancer Center. European Journal of Cancer (Oxford, England : 1990). 49: 3076-82. PMID 23876834 DOI: 10.1016/j.ejca.2013.06.014  0.058
2016 Meiler J, Sliwoski G, Schubert M, Stichel J, Beck-Sickinger A, Weaver D. Discovery of novel small-molecule modulators of the human Y4receptor Neuropeptides. 55: 18. DOI: 10.1016/j.npep.2015.11.050  0.057
2011 Lowe EW, Butkiewicz M, Spellings M, Omlor A, Meiler J. Comparative analysis of machine learning techniques for the prediction of logP Ieee Ssci 2011 - Symposium Series On Computational Intelligence - Cibcb 2011: 2011 Ieee Symposium On Computational Intelligence in Bioinformatics and Computational Biology. 35-40. DOI: 10.1109/CIBCB.2011.5948478  0.054
2012 Butkiewicz M, Lowe EW, Meiler J. BclChemInfo - Qualitative analysis of machine learning models for activation of HSD involved in Alzheimer's Disease 2012 Ieee Symposium On Computational Intelligence and Computational Biology, Cibcb 2012. 329-334. DOI: 10.1109/CIBCB.2012.6217248  0.053
2006 Meiler J, Schuler M. Therapeutic targeting of apoptotic pathways in cancer Current Drug Targets. 7: 1361-1369. PMID 17073598 DOI: 10.2174/138945006778559175  0.052
1989 Matz R, Meiler J, Haarer D. X-Ray Photoemission Investigation of Excimer Laser Induced Etching of InP Mrs Proceedings. 158. DOI: 10.1557/PROC-158-307  0.051
1977 Meiler J. [Modulation transfer function of the radiograph (author's transl)]. Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin. 125: 559-63. PMID 137855 DOI: 10.1055/s-0029-1230519  0.046
2020 Voigtmann F, Wolf P, Landgraf K, Stein R, Kratzsch J, Schmitz S, Jamra RA, Blüher M, Meiler J, Beck-Sickinger AG, Kiess W, Körner A. Identification of a novel leptin receptor (LEPR) variant and proof of functional relevance directing treatment decisions in patients with morbid obesity. Metabolism: Clinical and Experimental. 154438. PMID 33221380 DOI: 10.1016/j.metabol.2020.154438  0.045
1978 Meiler J. [Modulation transmission function and detail recognition in tomograms (author's transl)]. Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin. 127: 582-5. PMID 146010 DOI: 10.1055/s-0029-1230770  0.044
2012 Kasper S, Meiler J, Schuler M. Antibodies for adoptive immunotherapy of solid cancers | Antikörper zur adoptiven Immuntherapie solider Tumoren Onkologe. 18: 757-769. DOI: 10.1007/s00761-012-2257-3  0.043
2022 Choo CH, Chung DD, Ledwitch KV, Kassels A, Meiler J, Aldave AJ. Confirmation of association of p.Ser591Phe mutation with variant lattice corneal dystrophy. Ophthalmic Genetics. 1-4. PMID 35315300 DOI: 10.1080/13816810.2022.2050766  0.041
1998 Wendt MA, Meiler J, Weinhold F, Farrar TC. Solvent and concentration dependence of the hydroxyl chemical shift of methanol Molecular Physics. 93: 145-151. DOI: 10.1080/00268979809482198  0.037
1986 Meiler J. [Effective prefilter and patient dosage]. Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin. 144: 100-4. PMID 3003823 DOI: 10.1055/s-2008-1048749  0.027
1999 Brabletz T, Jung A, Hlubek F, Löhberg C, Meiler J, Suchy U, Kirchner T. Negative regulation of CD4 expression in T cells by the transcriptional repressor ZEB International Immunology. 11: 1701-1708. PMID 10508188 DOI: 10.1093/intimm/11.10.1701  0.027
1977 Meiler J. [Limitations of detail recognition in radiographs due to threshold contrast values (author's transl)]. Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin. 127: 179-82. PMID 143414 DOI: 10.1055/S-0029-1230681  0.026
1991 Meiler JG. Biomass research [2] Chemical and Engineering News. 69: 2.  0.025
2014 Pabo EF, Meiler J, Matthias T. Wafer bonding process for building MEMS devices Proceedings of Spie - the International Society For Optical Engineering. 9257. DOI: 10.1117/12.2064826  0.022
1987 Meiler J. Anode filtration and its contribution to the total inherent filtration of an x-ray tube | Die Anodenfilterung und ihr Anteil an der Gesamtvorfilterung eines Röntgenstrahlers Rontgenpraxis. 40: 165-168. PMID 3603223  0.021
1992 Meiler J. Dependence on radiation exposure in radiography | ABHANGIGKEITEN DER STRAHLENEXPOSITION BEI RONTGENAUFNAHMEN Aktuelle Radiologie. 2: 16-18. PMID 1547289  0.02
2015 Seidel C, Oechsle K, Lorch A, Dieing A, Hentrich M, Hornig M, Grünwald V, Cathomas R, Meiler J, de Wit M, Bokemeyer C. Efficacy and safety of gemcitabine, oxaliplatin, and paclitaxel in cisplatin-refractory germ cell cancer in routine care-Registry data from an outcomes research project of the German Testicular Cancer Study Group Urologic Oncology: Seminars and Original Investigations. DOI: 10.1016/j.urolonc.2015.11.007  0.019
1987 Meiler J. Pre-filtration of an x-ray radiation source in 2-pulse operation | Die Vorfilterung eines Röntgenstrahlers bei 2-Puls-Betrieb Rontgenpraxis. 40: 331-333. PMID 3660107  0.013
1994 Matz R, Meiler J. Photochemical etching of III/V semiconductors for integrated optoelectronics Galvanotechnik. 85: 1669-1679.  0.011
1987 Köhler W, Meiler J, Friedrich J. Tunneling dynamics of doped organic low-temperature glasses as probed by a photophysical hole-burning system Physical Review B. 35: 4031-4037. DOI: 10.1103/PhysRevB.35.4031  0.011
1989 Meiler J. The filter of an X-ray apparatus and radiation exposure of a patient | DIE VORFILTERUNG EINES RONTGENSTRAHLERS UND DIE STRAHLENEXPOSITION DES PATIENTEN Rontgenpraxis. 42: 119-123. PMID 2711262  0.01
1988 Meiler J. X-ray radiation in 2-pulse operation | DIE RONTGENSTRAHLUNG BEIM 2-PULS-BETRIEB Rontgenpraxis. 41: 111-115. PMID 3291144  0.01
1987 Meiler J. Radiation burden of the patient in roentgen exposures | Die Strahlenbelastung des Patienten bei Röntgenaufnahmen Rontgenpraxis. 40: 57-64. PMID 3576373  0.01
1987 Meiler J, Friedrich J. Dispersive relaxation and spectral diffusion in a doped alcohol glass: the influence of sample aging Chemical Physics Letters. 134: 263-267. DOI: 10.1016/0009-2614(87)87133-6  0.01
1964 Meiler J. Der Wandel der Röntgenapparatur und des Röhrenspannungsverlaufes in seinen Auswirkungen auf die Aufnahmetechnik RöFo - Fortschritte Auf Dem Gebiet Der RöNtgenstrahlen Und Der Bildgebenden Verfahren. 101: 547-556. DOI: 10.1055/S-0029-1227593  0.01
1959 Meiler J. Ermöglicht ein Nachleuchten des Lumineszenzmaterials einen geringeren Energieaufwand für eine Röntgenaufnahme? RöFo - Fortschritte Auf Dem Gebiet Der RöNtgenstrahlen Und Der Bildgebenden Verfahren. 90: 255-260. DOI: 10.1055/S-0029-1226277  0.01
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