Loren D. Walensky

Affiliations: 
Chemistry and Chemical Biology Harvard University, Cambridge, MA, United States 
Area:
General Chemistry, Molecular Biology
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"Loren Walensky"
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Publications

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McHenry MW, Shi P, Camara CM, et al. (2024) Covalent inhibition of pro-apoptotic BAX. Nature Chemical Biology
Adhikary U, Paulo JA, Godes M, et al. (2023) Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction. Cell Reports. 42: 113176
Hawley KM, Eclov RJ, Schnorenberg MR, et al. (2022) Inhibition of FOXP3 by stapled alpha-helical peptides dampens regulatory T cell function. Proceedings of the National Academy of Sciences of the United States of America. 119: e2209044119
Prew MS, Adhikary U, Choi DW, et al. (2022) MCL-1 is a master regulator of cancer dependency on fatty acid oxidation. Cell Reports. 41: 111445
Bloch NB, Wales TE, Prew MS, et al. (2021) The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core. Nature Communications. 12: 4932
Cathcart AM, Bird GH, Wales TE, et al. (2020) Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer. Nature Chemical Biology
Korshavn KJ, Wales TE, Bird GH, et al. (2020) A redox switch regulates the structure and function of anti-apoptotic BFL-1. Nature Structural & Molecular Biology
Hauseman ZJ, Harvey EP, Newman CE, et al. (2020) Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization. Molecular Cell
Harvey EP, Hauseman ZJ, Cohen DT, et al. (2020) Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chemical Biology
Ben-Nun Y, Seo HS, Harvey EP, et al. (2020) Identification of a Structural Determinant for Selective Targeting of HDMX. Structure (London, England : 1993)
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