| Year |
Citation |
Score |
| 2018 |
Kwak SH, Shin S, Lee JH, Shim JK, Kim M, Lee SD, Lee A, Bae J, Park JH, Abdelrahman A, Müller CE, Cho SK, Kang SG, Bae MA, Yang JY, ... Ko H, et al. Synthesis and structure-activity relationships of quinolinone and quinoline-based P2X7 receptor antagonists and their anti-sphere formation activities in glioblastoma cells. European Journal of Medicinal Chemistry. 151: 462-481. PMID 29649742 DOI: 10.1016/J.Ejmech.2018.03.023 |
0.578 |
|
| 2017 |
Jung YH, Kim YC, Kim YO, Lin H, Cho JH, Park JH, Lee SD, Bae J, Kang KM, Kim YG, Pae AN, Ko H, Park CS, Yoon MH. Discovery of Potent Antiallodynic Agents for Neuropathic Pain Targeting P2X3 Receptors. Acs Chemical Neuroscience. PMID 28323403 DOI: 10.1021/acschemneuro.6b00401 |
0.592 |
|
| 2016 |
Kwak SH, Kang JA, Kim M, Lee SD, Park JH, Park SG, Ko H, Kim YC. Discovery and structure-activity relationship studies of quinolinone derivatives as potent IL-2 suppressive agents. Bioorganic & Medicinal Chemistry. PMID 27647370 DOI: 10.1016/j.bmc.2016.08.051 |
0.437 |
|
| 2016 |
Lee SM, Yoon KB, Lee HJ, Kim J, Chung YK, Cho WJ, Mukai C, Choi S, Kang KW, Han SY, Ko H, Kim YC. The discovery of 2,5-isomers of triazole-pyrrolopyrimidine as selective Janus kinase 2 (JAK2) inhibitors versus JAK1 and JAK3. Bioorganic & Medicinal Chemistry. PMID 27555284 DOI: 10.1016/J.Bmc.2016.08.008 |
0.493 |
|
| 2016 |
Park JH, Williams DR, Lee JH, Lee SD, Lee JH, Ko H, Lee GE, Kim S, Lee JM, Abdelrahman A, Müller CE, Jung DW, Kim YC. Potent Suppressive Effects of 1-Piperidinylimidazole Based Novel P2X7 Receptor Antagonists on Cancer Cell Migration and Invasion. Journal of Medicinal Chemistry. PMID 27427902 DOI: 10.1021/Acs.Jmedchem.5B01690 |
0.603 |
|
| 2016 |
Kim BK, Ko H, Jeon ES, Ju ES, Jeong LS, Kim YC. 2,3,4-Trihydroxybenzyl-hydrazide analogues as novel potent coxsackievirus B3 3C protease inhibitors. European Journal of Medicinal Chemistry. 120: 202-216. PMID 27191615 DOI: 10.1016/j.ejmech.2016.03.085 |
0.474 |
|
| 2015 |
Park JH, Lee GE, Lee SD, Ko H, Kim YC. Structure-activity relationship studies of pyrimidine-2,4-dione derivatives as potent P2X7 receptor antagonists. European Journal of Medicinal Chemistry. 106: 180-193. PMID 26547056 DOI: 10.1016/j.ejmech.2015.10.036 |
0.711 |
|
| 2015 |
Kwak SH, Lee WG, Lee YJ, Lee SD, Kim YC, Ko H. Discovery of novel purine-based heterocyclic P2X7 receptor antagonists. Bioorganic Chemistry. 61: 58-65. PMID 26123174 DOI: 10.1016/j.bioorg.2015.06.003 |
0.552 |
|
| 2015 |
You H, Yoon HE, Jeong PH, Ko H, Yoon JH, Kim YC. Pheophorbide-a conjugates with cancer-targeting moieties for targeted photodynamic cancer therapy. Bioorganic & Medicinal Chemistry. 23: 1453-62. PMID 25753328 DOI: 10.1016/j.bmc.2015.02.014 |
0.558 |
|
| 2015 |
Park JH, Lee GE, Lee SD, Hien TT, Kim S, Yang JW, Cho JH, Ko H, Lim SC, Kim YG, Kang KW, Kim YC. Discovery of novel 2,5-dioxoimidazolidine-based P2X(7) receptor antagonists as constrained analogues of KN62. Journal of Medicinal Chemistry. 58: 2114-34. PMID 25597334 DOI: 10.1021/jm500324g |
0.596 |
|
| 2015 |
Kwak SH, Kim MJ, Lee SD, You H, Kim YC, Ko H. Solid-phase synthesis of quinolinone library. Acs Combinatorial Science. 17: 60-9. PMID 25437883 DOI: 10.1021/co5001585 |
0.6 |
|
| 2015 |
Moon S, Bae JY, Son HK, Lee DY, Park G, You H, Ko H, Kim YC, Kim J. RUNX3 confers sensitivity to pheophorbide a-photodynamic therapy in human oral squamous cell carcinoma cell lines. Lasers in Medical Science. 30: 499-507. PMID 23700080 DOI: 10.1007/s10103-013-1350-1 |
0.369 |
|
| 2013 |
Cho JH, Jung KY, Jung Y, Kim MH, Ko H, Park CS, Kim YC. Design and synthesis of potent and selective P2X₃ receptor antagonists derived from PPADS as potential pain modulators. European Journal of Medicinal Chemistry. 70: 811-30. PMID 24246730 DOI: 10.1016/j.ejmech.2013.10.026 |
0.68 |
|
| 2012 |
Lee WG, Lee SD, Cho JH, Jung Y, Kim JH, Hien TT, Kang KW, Ko H, Kim YC. Structure-activity relationships and optimization of 3,5-dichloropyridine derivatives as novel P2X(7) receptor antagonists. Journal of Medicinal Chemistry. 55: 3687-98. PMID 22400713 DOI: 10.1021/jm2012326 |
0.628 |
|
| 2012 |
Lee WG, Kim WS, Park SG, Kim H, Hong J, Ko H, Kim YC. Immunosuppressive effects of subglutinol derivatives. Chemmedchem. 7: 218-22. PMID 22114006 DOI: 10.1002/Cmdc.201100409 |
0.396 |
|
| 2012 |
Lee S, Lee W, Kim Y, Ko H. CorrigendumCorrigendum to “Synthesis and biological evaluation of α, β unsaturated lactones as potent immunosuppressive agents” [Bioorg. Med. Chem. Lett., 2011, 21, 5726–5729] Bioorganic & Medicinal Chemistry Letters. 22: 1287. DOI: 10.1016/J.Bmcl.2011.12.010 |
0.368 |
|
| 2011 |
You H, Yoon HE, Yoon JH, Ko H, Kim YC. Synthesis of pheophorbide-a conjugates with anticancer drugs as potential cancer diagnostic and therapeutic agents. Bioorganic & Medicinal Chemistry. 19: 5383-91. PMID 21873067 DOI: 10.1016/j.bmc.2011.07.058 |
0.394 |
|
| 2011 |
Lee SM, Lee WG, Kim YC, Kim YC, Ko H. Synthesis and biological evaluation of α,β-unsaturated lactones as potent immunosuppressive agents. Bioorganic & Medicinal Chemistry Letters. 21: 5726-9. PMID 21873054 DOI: 10.1016/j.bmcl.2011.08.020 |
0.424 |
|
| 2011 |
You H, Youn HS, Im I, Bae MH, Lee SK, Ko H, Eom SH, Kim YC. Design, synthesis and X-ray crystallographic study of NAmPRTase inhibitors as anti-cancer agents. European Journal of Medicinal Chemistry. 46: 1153-64. PMID 21330015 DOI: 10.1016/j.ejmech.2011.01.034 |
0.451 |
|
| 2010 |
Maruoka H, Barrett MO, Ko H, Tosh DK, Melman A, Burianek LE, Balasubramanian R, Berk B, Costanzi S, Harden TK, Jacobson KA. Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications. Journal of Medicinal Chemistry. 53: 4488-501. PMID 20446735 DOI: 10.1021/Jm100287T |
0.81 |
|
| 2010 |
Das A, Ko H, Burianek LE, Barrett MO, Harden TK, Jacobson KA. Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. Journal of Medicinal Chemistry. 53: 471-80. PMID 19902968 DOI: 10.1021/Jm901432G |
0.638 |
|
| 2009 |
Lee JY, Yu J, Cho WJ, Ko H, Kim YC. Synthesis and structure-activity relationships of pyrazolodiazepine derivatives as human P2X7 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 19: 6053-8. PMID 19800793 DOI: 10.1016/j.bmcl.2009.09.053 |
0.577 |
|
| 2009 |
Carter RL, Fricks IP, Barrett MO, Burianek LE, Zhou Y, Ko H, Das A, Jacobson KA, Lazarowski ER, Harden TK. Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor. Molecular Pharmacology. 76: 1341-8. PMID 19759354 DOI: 10.1124/Mol.109.058578 |
0.719 |
|
| 2009 |
Ko H, Das A, Carter RL, Fricks IP, Zhou Y, Ivanov AA, Melman A, Joshi BV, Kovác P, Hajduch J, Kirk KL, Harden TK, Jacobson KA. Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose. Bioorganic & Medicinal Chemistry. 17: 5298-311. PMID 19502066 DOI: 10.1016/J.Bmc.2009.05.024 |
0.786 |
|
| 2009 |
Cosyn L, Van Calenbergh S, Joshi BV, Ko H, Carter RL, Kendall Harden T, Jacobson KA. Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives. Bioorganic & Medicinal Chemistry Letters. 19: 3002-5. PMID 19419868 DOI: 10.1016/J.Bmcl.2009.04.027 |
0.748 |
|
| 2009 |
Jacobson KA, Ivanov AA, de Castro S, Harden TK, Ko H. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signalling. 5: 75-89. PMID 18600475 DOI: 10.1007/S11302-008-9106-2 |
0.821 |
|
| 2008 |
Ko H, Carter RL, Cosyn L, Petrelli R, de Castro S, Besada P, Zhou Y, Cappellacci L, Franchetti P, Grifantini M, Van Calenbergh S, Harden TK, Jacobson KA. Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorganic & Medicinal Chemistry. 16: 6319-32. PMID 18514530 DOI: 10.1016/J.Bmc.2008.05.013 |
0.83 |
|
| 2007 |
Ko H, Fricks I, Ivanov AA, Harden TK, Jacobson KA. Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor. Journal of Medicinal Chemistry. 50: 2030-9. PMID 17407275 DOI: 10.1021/Jm061222W |
0.806 |
|
| 2007 |
Ivanov AA, Ko H, Cosyn L, Maddileti S, Besada P, Fricks I, Costanzi S, Harden TK, Calenbergh SV, Jacobson KA. Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. Journal of Medicinal Chemistry. 50: 1166-76. PMID 17302398 DOI: 10.1021/Jm060903O |
0.787 |
|
| 2006 |
Besada P, Shin DH, Costanzi S, Ko H, Mathé C, Gagneron J, Gosselin G, Maddileti S, Harden TK, Jacobson KA. Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. Journal of Medicinal Chemistry. 49: 5532-43. PMID 16942026 DOI: 10.1021/Jm060485N |
0.814 |
|
| 2006 |
Jacobson KA, Costanzi S, Joshi BV, Besada P, Shin DH, Ko H, Ivanov AA, Mamedova L. Agonists and antagonists for P2 receptors. Novartis Foundation Symposium. 276: 58-68; discussion 68. PMID 16805423 DOI: 10.1002/9780470032244.Ch6 |
0.738 |
|
| 2002 |
Kim S, Ko H, Park JE, Jung S, Lee SK, Chun YJ. Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. Journal of Medicinal Chemistry. 45: 160-4. PMID 11754588 DOI: 10.1021/jm010298j |
0.304 |
|
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