Nunzio Bottini - Publications

Affiliations: 
Genetic, Molecular, and Cell Biology University of Southern California, Los Angeles, CA, United States 
Area:
Molecular Biology

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Year Citation  Score
2024 Stanford SM, Nguyen TP, Chang J, Zhao Z, Hackman GL, Santelli E, Sanders CM, Katiki M, Dondossola E, Brauer BL, Diaz MA, Zhan Y, Ramsey SH, Watson PA, Sankaran B, ... ... Bottini N, et al. Targeting prostate tumor low-molecular weight tyrosine phosphatase for oxidation-sensitizing therapy. Science Advances. 10: eadg7887. PMID 38295166 DOI: 10.1126/sciadv.adg7887  0.624
2023 Stanford SM, Bottini N. Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders. Nature Reviews. Drug Discovery. 1-22. PMID 36693907 DOI: 10.1038/s41573-022-00618-w  0.665
2022 Imbery JF, Heinzelbecker J, Jebsen JK, McGowan M, Myklebust C, Bottini N, Stanford SM, Skånland SS, Tveita A, Tjønnfjord GE, Munthe LA, Szodoray P, Nakken B. T-helper cell regulation of CD45 phosphatase activity by galectin-1 and CD43 governs chronic lymphocytic leukaemia proliferation. British Journal of Haematology. PMID 35655388 DOI: 10.1111/bjh.18285  0.647
2021 Szodoray P, Andersen TK, Heinzelbecker J, Imbery JF, Huszthy PC, Stanford SM, Bogen B, Landsverk OB, Bottini N, Tveita A, Munthe LA, Nakken B. Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity. Cell Reports. 36: 109525. PMID 34380042 DOI: 10.1016/j.celrep.2021.109525  0.652
2021 Stanford SM, Diaz MA, Ardecky RJ, Zou J, Roosild T, Holmes ZJ, Nguyen TP, Hedrick MP, Rodiles S, Guan A, Grotegut S, Santelli E, Chung TDY, Jackson MR, Bottini N, et al. Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase. Journal of Medicinal Chemistry. PMID 33914534 DOI: 10.1021/acs.jmedchem.0c02126  0.652
2021 Stanford SM, Collins M, Diaz MA, Holmes ZJ, Gries P, Bliss MR, Lodi A, Zhang V, Tiziani S, Bottini N. The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy. Journal of Cellular Physiology. PMID 33615467 DOI: 10.1002/jcp.30307  0.679
2020 Hsieh WC, Svensson MN, Zoccheddu M, Tremblay ML, Sakaguchi S, Stanford SM, Bottini N. PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis. Jci Insight. 5. PMID 33055428 DOI: 10.1172/jci.insight.141868  0.662
2020 Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, ... ... Bottini N, et al. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Science Advances. 6: eaba4353. PMID 32637608 DOI: 10.1126/Sciadv.Aba4353  0.69
2020 Yang S, Svensson MND, Harder NHO, Hsieh WC, Santelli E, Kiosses WB, Moresco JJ, Yates JR, King CC, Liu L, Stanford SM, Bottini N. PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling. Science Signaling. 13. PMID 32184287 DOI: 10.1126/Scisignal.Aaw8130  0.706
2020 Wen Y, Yang S, Wakabayashi K, Svensson MND, Stanford SM, Santelli E, Bottini N. RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain. The Journal of Biological Chemistry. PMID 32139509 DOI: 10.1074/Jbc.Ra119.011808  0.648
2020 Stanford SM, Diaz MA, Zou JJ, Ardecky RJ, Pinkerton A, Bottini N. 1742-P: Targeting the Low Molecular Weight Protein Tyrosine Phosphatase for Obesity-Associated Diabetes Therapy Diabetes. 69. DOI: 10.2337/Db20-1742-P  0.655
2019 Liu L, Hu F, Wang H, Wu X, Eltahan AS, Stanford S, Bottini N, Xiao H, Bottini M, Guo W, Liang XJ. Secreted Protein Acidic and Rich in Cysteine Mediated Biomimetic Delivery of Methotrexate by Albumin-Based Nanomedicines for Rheumatoid Arthritis Therapy. Acs Nano. PMID 30978282 DOI: 10.1021/Acsnano.9B01710  0.672
2019 Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V, Sacchetti C, Zoccheddu M, Lonic A, Li X, Boyle DL, Hammaker D, Meng TC, ... ... Bottini N, et al. PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes. Annals of the Rheumatic Diseases. PMID 30808624 DOI: 10.1136/Annrheumdis-2018-213799  0.683
2019 Svensson MN, Doody KM, Schmiedel BJ, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, ... ... Bottini N, et al. Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity. The Journal of Clinical Investigation. PMID 30620725 DOI: 10.1172/Jci123267  0.404
2018 Mustelin T, Bottini N, Stanford SM. The contribution of PTPN22 to rheumatological disease. Arthritis & Rheumatology (Hoboken, N.J.). PMID 30507064 DOI: 10.1002/Art.40790  0.691
2018 Zhao M, Svensson MND, Venken K, Chawla A, Liang S, Engel I, Mydel P, Day J, Elewaut D, Bottini N, Kronenberg M. Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70. Nature Communications. 9: 2627. PMID 29980684 DOI: 10.1038/S41467-018-05095-7  0.371
2018 STANFORD S, ZHANG V, BOTTINI N. The Tyrosine Phosphatase LMPTP Is a Key Promoter of Adipogenesis Diabetes. 67: 2421-PUB. DOI: 10.2337/Db18-2421-Pub  0.682
2017 Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, ... Bottini N, et al. PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis. Nature Communications. 8: 1060. PMID 29057934 DOI: 10.1038/S41467-017-01168-1  0.686
2017 Stanford SM, Bottini N. Targeting Tyrosine Phosphatases: Time to End the Stigma. Trends in Pharmacological Sciences. PMID 28412041 DOI: 10.1016/J.Tips.2017.03.004  0.668
2017 Sacchetti C, Bottini N. Protein Tyrosine Phosphatases in Systemic Sclerosis: Potential Pathogenic Players and Therapeutic Targets. Current Rheumatology Reports. 19: 28. PMID 28397126 DOI: 10.1007/S11926-017-0655-7  0.353
2017 Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, ... ... Bottini N, et al. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nature Chemical Biology. PMID 28346406 DOI: 10.1038/Nchembio.2344  0.673
2017 Doody KM, Bottini N, Firestein GS. Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes. Epigenomics. PMID 28322585 DOI: 10.2217/Epi-2016-0151  0.301
2016 Cho JH, Kim HO, Ju YJ, Kye YC, Lee GW, Lee SW, Yun CH, Bottini N, Webster K, Goodnow CC, Surh CD, King C, Sprent J. CD45-mediated control of TCR tuning in naïve and memory CD8(+) T cells. Nature Communications. 7: 13373. PMID 27841348 DOI: 10.1038/Ncomms13373  0.309
2016 Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS. Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation. Jci Insight. 1. PMID 27275015 DOI: 10.1172/Jci.Insight.86580  0.675
2016 Szodoray P, Stanford SM, Molberg Ø, Munthe LA, Bottini N, Nakken B. T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity. The Journal of Allergy and Clinical Immunology. PMID 27056269 DOI: 10.1016/J.Jaci.2016.01.035  0.679
2015 Fraser HI, Howlett S, Clark J, Rainbow DB, Stanford SM, Wu DJ, Hsieh YW, Maine CJ, Christensen M, Kuchroo V, Sherman LA, Podolin PL, Todd JA, Steward CA, Peterson LB, ... Bottini N, et al. Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice. Journal of Immunology (Baltimore, Md. : 1950). PMID 26438525 DOI: 10.4049/Jimmunol.1402654  0.688
2015 Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Aleman Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, ... ... Bottini N, et al. "Receptor protein tyrosine phosphatase alpha enhances rheumatoid synovial fibroblast signaling and promotes arthritis in mice". Arthritis & Rheumatology (Hoboken, N.J.). PMID 26414708 DOI: 10.1002/Art.39442  0.697
2015 Wade F, Quijada P, Al-Haffar KM, Awad SM, Kunhi M, Toko H, Marashly Q, Belhaj K, Zahid I, Al-Mohanna F, Stanford SM, Alvarez R, Liu Y, Colak D, Jordan MC, ... ... Bottini N, et al. Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy. The Journal of Pathology. PMID 26213100 DOI: 10.1002/Path.4594  0.657
2015 Kiris E, Nuss JE, Stanford SM, Wanner LM, Cazares L, Maestre MF, Du HT, Gomba GY, Burnett JC, Gussio R, Bottini N, Panchal RG, Kane CD, Tessarollo L, Bavari S. Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays. Plos One. 10: e0129264. PMID 26061731 DOI: 10.1371/Journal.Pone.0129264  0.666
2015 Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, ... ... Bottini N, et al. Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Science Translational Medicine. 7: 288ra76. PMID 25995222 DOI: 10.1126/Scitranslmed.Aaa4616  0.693
2015 Doody KM, Stanford SM, Sacchetti C, Svensson MND, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, ... ... Bottini N, et al. Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aaa4616  0.628
2014 Stanford SM, Aleman Muench GR, Bartok B, Sacchetti C, Kiosses WB, Sharma J, Maestre MF, Bottini M, Mustelin T, Boyle DL, Firestein GS, Bottini N. TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness. Annals of the Rheumatic Diseases. PMID 25378349 DOI: 10.1136/Annrheumdis-2014-205790  0.686
2014 de Jong PR, Takahashi N, Harris AR, Lee J, Bertin S, Jeffries J, Jung M, Duong J, Triano AI, Lee J, Niv Y, Herdman DS, Taniguchi K, Kim CW, Dong H, ... ... Bottini N, et al. Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. The Journal of Clinical Investigation. 124: 3793-806. PMID 25083990 DOI: 10.1172/Jci72340  0.678
2014 Doody KM, Bottini N. "PEST control": regulation of molecular barcodes by tyrosine phosphatases. Cell Research. 24: 1027-8. PMID 25081059 DOI: 10.1038/Cr.2014.100  0.338
2014 Stanford SM, Bottini N. PTPN22: the archetypal non-HLA autoimmunity gene. Nature Reviews. Rheumatology. 10: 602-11. PMID 25003765 DOI: 10.1038/Nrrheum.2014.109  0.713
2014 Fousteri G, Jofra T, Debernardis I, Stanford SM, Laurenzi A, Bottini N, Battaglia M. The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization. Clinical and Experimental Immunology. 178: 178-89. PMID 24905474 DOI: 10.1111/Cei.12393  0.695
2014 Wu DJ, Zhou W, Enouz S, Orrú V, Stanford SM, Maine CJ, Rapini N, Sawatzke K, Engel I, Fiorillo E, Sherman LA, Kronenberg M, Zehn D, Peterson E, Bottini N. Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells. Plos One. 9: e86677. PMID 24498279 DOI: 10.1371/Journal.Pone.0086677  0.705
2014 Ahmed VF, Bottini N, Barrios AM. Covalent inhibition of the lymphoid tyrosine phosphatase. Chemmedchem. 9: 296-9. PMID 24403103 DOI: 10.1002/Cmdc.201300404  0.316
2014 Bottini N, Peterson EJ. Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease. Annual Review of Immunology. 32: 83-119. PMID 24364806 DOI: 10.1146/Annurev-Immunol-032713-120249  0.407
2014 Stanford SM, Ahmed V, Barrios AM, Bottini N. Cellular biochemistry methods for investigating protein tyrosine phosphatases. Antioxidants & Redox Signaling. 20: 2160-78. PMID 24294920 DOI: 10.1089/Ars.2013.5731  0.678
2014 Stanford SM, Krishnamurthy D, Kulkarni RA, Karver CE, Bruenger E, Walker LM, Ma CT, Chung TD, Sergienko E, Bottini N, Barrios AM. pCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assays. Methods (San Diego, Calif.). 65: 165-74. PMID 23886911 DOI: 10.1016/J.Ymeth.2013.07.022  0.628
2013 Bottini N, Firestein GS. Epigenetics in rheumatoid arthritis: a primer for rheumatologists. Current Rheumatology Reports. 15: 372. PMID 24072602 DOI: 10.1007/S11926-013-0372-9  0.318
2013 Kulkarni RA, Vellore NA, Bliss MR, Stanford SM, Falk MD, Bottini N, Baron R, Barrios AM. Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors. Chembiochem : a European Journal of Chemical Biology. 14: 1640-7. PMID 23956195 DOI: 10.1002/Cbic.201300273  0.669
2013 Kulkarni RA, Stanford SM, Vellore NA, Krishnamurthy D, Bliss MR, Baron R, Bottini N, Barrios AM. Thiuram disulfides as pseudo-irreversible inhibitors of lymphoid tyrosine phosphatase. Chemmedchem. 8: 1561-8. PMID 23873737 DOI: 10.1002/Cmdc.201300215  0.659
2013 Wang Y, Shaked I, Stanford SM, Zhou W, Curtsinger JM, Mikulski Z, Shaheen ZR, Cheng G, Sawatzke K, Campbell AM, Auger JL, Bilgic H, Shoyama FM, Schmeling DO, Balfour HH, ... ... Bottini N, et al. The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity. 39: 111-22. PMID 23871208 DOI: 10.1016/J.Immuni.2013.06.013  0.672
2013 He Y, Liu S, Menon A, Stanford S, Oppong E, Gunawan AM, Wu L, Wu DJ, Barrios AM, Bottini N, Cato AC, Zhang ZY. A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases. Journal of Medicinal Chemistry. 56: 4990-5008. PMID 23713581 DOI: 10.1021/Jm400248C  0.689
2013 Sacchetti C, Rapini N, Magrini A, Cirelli E, Bellucci S, Mattei M, Rosato N, Bottini N, Bottini M. In vivo targeting of intratumor regulatory T cells using PEG-modified single-walled carbon nanotubes. Bioconjugate Chemistry. 24: 852-8. PMID 23682992 DOI: 10.1021/Bc400070Q  0.33
2013 Stanford SM, Maestre MF, Campbell AM, Bartok B, Kiosses WB, Boyle DL, Arnett HA, Mustelin T, Firestein GS, Bottini N. Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival. Arthritis and Rheumatism. 65: 1171-80. PMID 23335101 DOI: 10.1002/Art.37872  0.699
2013 Bottini N, Firestein GS. Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nature Reviews. Rheumatology. 9: 24-33. PMID 23147896 DOI: 10.1038/Nrrheum.2012.190  0.345
2013 Stanford SM, Bottini M, Bottini N. The role of LMPTP in the metabolic syndrome Protein Tyrosine Phosphatase Control of Metabolism. 203-220. DOI: 10.1007/978-1-4614-7855-3_11  0.647
2012 Stanford SM, Panchal RG, Walker LM, Wu DJ, Falk MD, Mitra S, Damle SS, Ruble D, Kaltcheva T, Zhang S, Zhang ZY, Bavari S, Barrios AM, Bottini N. High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45. Proceedings of the National Academy of Sciences of the United States of America. 109: 13972-7. PMID 22891353 DOI: 10.1073/Pnas.1205028109  0.698
2012 Stanford SM, Rapini N, Bottini N. Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity. Immunology. 137: 1-19. PMID 22862552 DOI: 10.1111/J.1365-2567.2012.03591.X  0.706
2012 Maine CJ, Hamilton-Williams EE, Cheung J, Stanford SM, Bottini N, Wicker LS, Sherman LA. PTPN22 alters the development of regulatory T cells in the thymus. Journal of Immunology (Baltimore, Md. : 1950). 188: 5267-75. PMID 22539785 DOI: 10.4049/Jimmunol.1200150  0.709
2011 Teruel M, Martin JE, González-Juanatey C, López-Mejias R, Miranda-Filloy JA, Blanco R, Balsa A, Pascual-Salcedo D, Rodriguez-Rodriguez L, Fernández-Gutierrez B, Ortiz AM, González-Alvaro I, Gómez-Vaquero C, Bottini N, Llorca J, et al. Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients. Arthritis Research & Therapy. 13: R116. PMID 21767392 DOI: 10.1186/Ar3401  0.339
2011 Stanford SM, Krishnamurthy D, Falk MD, Messina R, Debnath B, Li S, Liu T, Kazemi R, Dahl R, He Y, Yu X, Chan AC, Zhang ZY, Barrios AM, Woods VL, ... ... Bottini N, et al. Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. Journal of Medicinal Chemistry. 54: 1640-54. PMID 21341673 DOI: 10.1021/Jm101202J  0.704
2010 Delogu LG, Stanford SM, Santelli E, Magrini A, Bergamaschi A, Motamedchaboki K, Rosato N, Mustelin T, Bottini N, Bottini M. Carbon nanotube-based nanocarriers: the importance of keeping it clean. Journal of Nanoscience and Nanotechnology. 10: 5293-301. PMID 21125885 DOI: 10.1166/Jnn.2010.3083  0.647
2010 Sebastiani GD, Bottini N, Greco E, Saccucci P, Canu G, Lucarelli P, Gloria-Bottini F, Fontana L. A study of adenosine-deaminase genetic polymorphism in rheumatoid arthritis International Journal of Immunopathology and Pharmacology. 23: 791-795. PMID 20943049 DOI: 10.1177/039463201002300313  0.312
2010 Fiorillo E, Orrú V, Stanford SM, Liu Y, Salek M, Rapini N, Schenone AD, Saccucci P, Delogu LG, Angelini F, Manca Bitti ML, Schmedt C, Chan AC, Acuto O, Bottini N. Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue. The Journal of Biological Chemistry. 285: 26506-18. PMID 20538612 DOI: 10.1074/Jbc.M110.111104  0.707
2010 Stanford SM, Mustelin TM, Bottini N. Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases. Seminars in Immunopathology. 32: 127-36. PMID 20204370 DOI: 10.1007/S00281-010-0201-4  0.698
2010 Karver MR, Krishnamurthy D, Bottini N, Barrios AM. Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase. Journal of Inorganic Biochemistry. 104: 268-73. PMID 20083307 DOI: 10.1016/J.Jinorgbio.2009.12.012  0.328
2009 Karver MR, Krishnamurthy D, Kulkarni RA, Bottini N, Barrios AM. Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of Au(I) complexes. Journal of Medicinal Chemistry. 52: 6912-8. PMID 19888762 DOI: 10.1021/Jm901220M  0.335
2009 Shu YH, Hartiala J, Xiang AH, Trigo E, Lawrence JM, Allayee H, Buchanan TA, Bottini N, Watanabe RM. Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans. The Journal of Clinical Endocrinology and Metabolism. 94: 4094-102. PMID 19622628 DOI: 10.1210/Jc.2008-2751  0.301
2009 Liu Y, Stanford SM, Jog SP, Fiorillo E, Orrú V, Comai L, Bottini N. Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain. Biochemistry. 48: 7525-32. PMID 19586056 DOI: 10.1021/Bi900332F  0.667
2009 Delogu LG, Magrini A, Bergamaschi A, Rosato N, Dawson MI, Bottini N, Bottini M. Conjugation of antisense oligonucleotides to PEGylated carbon nanotubes enables efficient knockdown of PTPN22 in T lymphocytes. Bioconjugate Chemistry. 20: 427-31. PMID 19243140 DOI: 10.1021/Bc800540J  0.343
2009 Orrú V, Tsai SJ, Rueda B, Fiorillo E, Stanford SM, Dasgupta J, Hartiala J, Zhao L, Ortego-Centeno N, D'Alfonso S, Arnett FC, Wu H, Gonzalez-Gay MA, Tsao BP, ... ... Bottini N, et al. A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Human Molecular Genetics. 18: 569-79. PMID 18981062 DOI: 10.1093/Hmg/Ddn363  0.673
2008 Krishnamurthy D, Karver MR, Fiorillo E, Orrú V, Stanford SM, Bottini N, Barrios AM. Gold(I)-mediated inhibition of protein tyrosine phosphatases: a detailed in vitro and cellular study. Journal of Medicinal Chemistry. 51: 4790-5. PMID 18605719 DOI: 10.1021/Jm800101W  0.684
2008 Cato MH, D'Annibale F, Mills DM, Cerignoli F, Dawson MI, Bergamaschi E, Bottini N, Magrini A, Bergamaschi A, Rosato N, Rickert RC, Mustelin T, Bottini M. Cell-type specific and cytoplasmic targeting of PEGylated carbon nanotube-based nanoassemblies. Journal of Nanoscience and Nanotechnology. 8: 2259-69. PMID 18572636 DOI: 10.1166/Jnn.2008.501  0.307
2008 Saccucci P, Del Duca E, Rapini N, Verrotti A, Piccinini S, Maccari A, Canu G, Angelini F, Fontana L, Giannini C, Chiarelli F, Manca Bitti ML, Bottini N. Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy. Tissue Antigens. 71: 234-7. PMID 18179648 DOI: 10.1111/J.1399-0039.2007.00987.X  0.34
2008 Zoledziewska M, Perra C, Orrù V, Moi L, Frongia P, Congia M, Bottini N, Cucca F. Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes. Diabetes. 57: 229-34. PMID 17934143 DOI: 10.2337/Db07-0289  0.306
2007 Vang T, Miletic AV, Bottini N, Mustelin T. Protein tyrosine phosphatase PTPN22 in human autoimmunity. Autoimmunity. 40: 453-61. PMID 17729039 DOI: 10.1080/08916930701464897  0.368
2007 Nicotra M, Bottini N, La Torre M, Amante A, Bottini E, Gloria-Bottini F. Repeated spontaneous abortion. Cooperative effects of ADA and ACP1 genetic polymorphisms. American Journal of Reproductive Immunology (New York, N.Y. : 1989). 58: 1-10. PMID 17565542 DOI: 10.1111/J.1600-0897.2007.00483.X  0.323
2007 Gloria-Bottini F, Bottini N, Renzetti G, Bottini E. ACP1 and Th class of immunological disease: Evidence of interaction with gender International Archives of Allergy and Immunology. 143: 170-176. PMID 17284925 DOI: 10.1159/000099308  0.327
2007 Zhao L, Liu Y, Fiorillo E, Stanford S, Orru V, Bottini N. Functional Characterization of the Autoimmune-associated LYP-W620 Variant Clinical Immunology. 123: S127. DOI: 10.1016/J.Clim.2007.03.540  0.647
2006 Bottini N, Vang T, Cucca F, Mustelin T. Role of PTPN22 in type 1 diabetes and other autoimmune diseases. Seminars in Immunology. 18: 207-13. PMID 16697661 DOI: 10.1016/J.Smim.2006.03.008  0.353
2006 Nika K, Charvet C, Williams S, Tautz L, Bruckner S, Rahmouni S, Bottini N, Schoenberger SP, Baier G, Altman A, Mustelin T. Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation. Molecular and Cellular Biology. 26: 1806-16. PMID 16479000 DOI: 10.1128/Mcb.26.5.1806-1816.2006  0.379
2005 Mijakovic I, Petranovic D, Bottini N, Deutscher J, Ruhdal Jensen P. Protein-tyrosine phosphorylation in Bacillus subtilis. Journal of Molecular Microbiology and Biotechnology. 9: 189-97. PMID 16415592 DOI: 10.1159/000089647  0.325
2005 Wang Y, Vachon E, Zhang J, Cherepanov V, Kruger J, Li J, Saito K, Shannon P, Bottini N, Huynh H, Ni H, Yang H, McKerlie C, Quaggin S, Zhao ZJ, et al. Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. The Journal of Experimental Medicine. 202: 1587-97. PMID 16330817 DOI: 10.1084/Jem.20051108  0.331
2005 Vang T, Congia M, Macis MD, Musumeci L, Orrú V, Zavattari P, Nika K, Tautz L, Taskén K, Cucca F, Mustelin T, Bottini N. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nature Genetics. 37: 1317-9. PMID 16273109 DOI: 10.1038/Ng1673  0.395
2005 Wu H, Cantor RM, Graham DS, Lingren CM, Farwell L, Jager PL, Bottini N, Grossman JM, Wallace DJ, Hahn BH, Julkunen H, Hebert LA, Rovin BH, Birmingham DJ, Rioux JD, et al. Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease. Arthritis and Rheumatism. 52: 2396-402. PMID 16052563 DOI: 10.1002/Art.21223  0.308
2005 Mijakovic I, Musumeci L, Tautz L, Petranovic D, Edwards RA, Jensen PR, Mustelin T, Deutscher J, Bottini N. In vitro characterization of the Bacillus subtilis protein tyrosine phosphatase YwqE. Journal of Bacteriology. 187: 3384-90. PMID 15866923 DOI: 10.1128/Jb.187.10.3384-3390.2005  0.301
2005 Mustelin T, Vang T, Bottini N. Protein tyrosine phosphatases and the immune response. Nature Reviews. Immunology. 5: 43-57. PMID 15630428 DOI: 10.1038/Nri1530  0.372
2005 Ladner MB, Bottini N, Valdes AM, Noble JA. Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes. Human Immunology. 66: 60-4. PMID 15620463 DOI: 10.1016/J.Humimm.2004.09.016  0.384
2005 Tautz L, Bruckner S, Sareth S, Alonso A, Bogetz J, Bottini N, Pellecchia M, Mustelin T. Inhibition of Yersinia tyrosine phosphatase by furanyl salicylate compounds. The Journal of Biological Chemistry. 280: 9400-8. PMID 15615724 DOI: 10.1074/Jbc.M413122200  0.373
2004 Huynh H, Bottini N, Williams S, Cherepanov V, Musumeci L, Saito K, Bruckner S, Vachon E, Wang X, Kruger J, Chow CW, Pellecchia M, Monosov E, Greer PA, Trimble W, et al. Control of vesicle fusion by a tyrosine phosphatase. Nature Cell Biology. 6: 831-9. PMID 15322554 DOI: 10.1038/Ncb1164  0.329
2004 Bottini N, Gloria-Bottini F, Borgiani P, Antonacci E, Lucarelli P, Bottini E. Type 2 diabetes and the genetics of signal transduction: A study of interaction between adenosine deaminase and acid phosphatase locus 1 polymorphisms Metabolism: Clinical and Experimental. 53: 995-1001. PMID 15281007 DOI: 10.1016/J.Metabol.2004.03.006  0.345
2004 Mustelin T, Alonso A, Bottini N, Huynh H, Rahmouni S, Nika K, Louis-dit-Sully C, Tautz L, Togo SH, Bruckner S, Mena-Duran AV, al-Khouri AM. Protein tyrosine phosphatases in T cell physiology. Molecular Immunology. 41: 687-700. PMID 15220004 DOI: 10.1016/J.Molimm.2004.04.015  0.391
2004 Alonso A, Sasin J, Bottini N, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustelin T. Protein tyrosine phosphatases in the human genome Cell. 117: 699-711. PMID 15186772 DOI: 10.1016/J.Cell.2004.05.018  0.32
2004 Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, Rostamkhani M, MacMurray J, Meloni GF, Lucarelli P, Pellecchia M, Eisenbarth GS, Comings D, Mustelin T. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nature Genetics. 36: 337-8. PMID 15004560 DOI: 10.1038/Ng1323  0.358
2004 Alonso A, Bottini N, Bruckner S, Rahmouni S, Williams S, Schoenberger SP, Mustelin T. Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH. The Journal of Biological Chemistry. 279: 4922-8. PMID 14623872 DOI: 10.1074/Jbc.M308978200  0.386
2004 Nika K, Hyunh H, Williams S, Paul S, Bottini N, Taskén K, Lombroso PJ, Mustelin T. Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location. The Biochemical Journal. 378: 335-42. PMID 14613483 DOI: 10.1042/Bj20031244  0.366
2003 Huynh H, Wang X, Li W, Bottini N, Williams S, Nika K, Ishihara H, Godzik A, Mustelin T. Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells. Journal of Immunology (Baltimore, Md. : 1950). 171: 6661-71. PMID 14662869 DOI: 10.4049/Jimmunol.171.12.6661  0.332
2003 Mustelin T, Rahmouni S, Bottini N, Alonso A. Role of protein tyrosine phosphatases in T cell activation. Immunological Reviews. 191: 139-47. PMID 12614357 DOI: 10.1034/J.1600-065X.2003.00014.X  0.394
2002 Bottini N, Saccucci P, Piciullo A, Iannetti P, Lucarini N, Lucarelli P, Gloria-Bottini F, Curatolo P. Convulsive disorder and the genetics of signal transduction; a study of a low molecular weight protein tyrosine phosphatase in a pediatric sample. Neuroscience Letters. 333: 159-62. PMID 12429372 DOI: 10.1016/S0304-3940(02)00758-9  0.308
2002 Bottini N, Mao XQ, Borgiani P, Saccucci P, Stefanini L, Greco E, Fontana L, Shirakawa T, Hopkin JM. Low molecular weight PTP-IL-4RA interaction in atopy predisposition. Allergy. 57: 10-2. PMID 12144546 DOI: 10.1034/J.1398-9995.57.S72.4.X  0.304
2002 Birle D, Bottini N, Williams S, Huynh H, deBelle I, Adamson E, Mustelin T. Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation. Journal of Immunology (Baltimore, Md. : 1950). 169: 286-91. PMID 12077256 DOI: 10.4049/Jimmunol.169.1.286  0.366
2002 Bottini N, Stefanini L, Williams S, Alonso A, Jascur T, Abraham RT, Couture C, Mustelin T. Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP). The Journal of Biological Chemistry. 277: 24220-4. PMID 11976341 DOI: 10.1074/Jbc.M202885200  0.398
2002 Bottini N, Meloni GF, Borgiani P, Giorgini A, Buzzetti R, Pozzilli P, Lucarelli P, Gloria-Bottini F. Genotypes of cytosolic low-molecular-weight protein-tyrosine-phosphatase correlate with age at onset of type 1 diabetes in a sex-specific manner Metabolism: Clinical and Experimental. 51: 419-422. PMID 11912546 DOI: 10.1053/Meta.2002.31317  0.33
2001 Bottini E, Palmarino R, Lucarelli P, Lista F, Bottini N. ACP1 and human adaptability: Association with past malarial morbidity in the Sardinian population American Journal of Human Biology. 13: 753-760. PMID 11748814 DOI: 10.1002/Ajhb.1121  0.302
2000 Bottini N, Gloria-Bottini F, Lucarini N, Ronchetti PG, Fontana L. Inflammatory bowel disease: Are there gender differences in the genetics of signal transduction? A preliminary study of cytosolic low molecular weight protein tyrosine phosphatase Disease Markers. 16: 163-166. PMID 11381200 DOI: 10.1155/2000/101739  0.318
1998 Bottini E, Cosmi E, Nicotra M, Santeusanio G, La Torre M, Bottini N, Lucarini N. The genetics of signal transduction and the feto-maternal relationship. A study of cytosolic low molecular weight phosphotyrosine phosphatase. Disease Markers. 14: 143-50. PMID 10427472 DOI: 10.1155/1998/861096  0.36
Low-probability matches (unlikely to be authored by this person)
2011 Rodríguez-Rodríguez L, Taib WR, Topless R, Steer S, González-Escribano MF, Balsa A, Pascual-Salcedo D, González-Gay MA, Raya E, Fernandez-Gutierrez B, González-Álvaro I, Bottini N, Witte T, Viken MK, Coenen MJ, et al. The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples. Arthritis and Rheumatism. 63: 365-72. PMID 21279993 DOI: 10.1002/Art.30145  0.3
2009 Tsai SJ, Sen U, Zhao L, Greenleaf WB, Dasgupta J, Fiorillo E, Orrú V, Bottini N, Chen XS. Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation . Biochemistry. 48: 4838-45. PMID 19371084 DOI: 10.1021/Bi900166Y  0.298
2001 Bottini E, Lucarini N, Amante A, Bottini N, Faggioni G. The genetics of signal transduction and the outcome of diagnostic tests in growth retardation Journal of Endocrinology. 171: 267-271. PMID 11691646 DOI: 10.1677/Joe.0.1710267  0.298
2011 Diaz-Gallo LM, Espino-Paisán L, Fransen K, Gómez-García M, van Sommeren S, Cardeña C, Rodrigo L, Mendoza JL, Taxonera C, Nieto A, Alcain G, Cueto I, López-Nevot MA, Bottini N, Barclay ML, et al. Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis. Inflammatory Bowel Diseases. 17: 2287-94. PMID 21287672 DOI: 10.1186/1479-5876-8-S1-P2  0.297
2008 Ammendola M, Bottini N, Pietropolli A, Saccucci P, Gloria-Bottini F. Association between PTPN22 and endometriosis. Fertility and Sterility. 89: 993-4. PMID 17624340 DOI: 10.1016/J.Fertnstert.2007.04.008  0.297
2000 Greene LS, Bottini N, Borgiani P, Gloria-Bottini F. Acid phosphatase locus 1 (ACP1): Possible relationship of allelic variation to body size and human population adaptation to thermal stress-A theoretical perspective. American Journal of Human Biology : the Official Journal of the Human Biology Council. 12: 688-701. PMID 11534062 DOI: 10.1002/1520-6300(200009/10)12:5<688::Aid-Ajhb14>3.0.Co;2-C  0.297
2022 Tun MT, Yang S, Forti FL, Santelli E, Bottini N. Macromolecular crowding amplifies allosteric regulation of T-Cell Protein Tyrosine Phosphatase. The Journal of Biological Chemistry. 102655. PMID 36328244 DOI: 10.1016/j.jbc.2022.102655  0.295
1998 Antonacci E, Bottini N, Gloria-Bottini F, Amante A, Lucarini N. Diabetic polyneuropathy and the genetics of signal transduction. Evidence of association with cytosolic low molecular weight phosphotyrosine-phosphatase International Journal of Immunopathology and Pharmacology. 11: 179-182. DOI: 10.1177/039463209801100308  0.295
2009 Steck AK, Baschal EE, Jasinski JM, Boehm BO, Bottini N, Concannon P, Julier C, Morahan G, Noble JA, Polychronakos C, She JX, Eisenbarth GS. Rs2476601 T allele (R620W) defines high-risk PTPN22 type i diabetes-associated haplotypes with preliminary evidence for an additional protective haplotype Genes and Immunity. 10: S21-S26. PMID 19956096 DOI: 10.1038/Gene.2009.87  0.294
2002 Bottini N, MacMurray J, Rostamkani M, McGue M, Iacono WG, Comings DE. Association between the low molecular weight cytosolic acid phosphatase gene ACP1*A and comorbid features of Tourette syndrome. Neuroscience Letters. 330: 198-200. PMID 12231445 DOI: 10.1016/S0304-3940(02)00750-4  0.294
2012 Teruel M, Martin JE, Ortego-Centeno N, Jiménez-Alonso J, Sánchez-Román J, de Ramón E, Gonzalez-Escribano MF, Pons-Estel BA, D'Alfonso S, Sebastiani GD, Witte T, Bottini N, González-Gay MA, Alarcón-Riquelme ME, Martin J. Novel association of acid phosphatase locus 1*C allele with systemic lupus erythematosus. Human Immunology. 73: 107-10. PMID 22064183 DOI: 10.1016/J.Humimm.2011.10.012  0.289
2008 Gloria-Bottini F, Bottini N, Magrini A, Renzetti G, Martinoli R, Bergamaschi A, Bottini E. Low birth weight and allergy: possible pleiotropic effect of ACP1. Human Biology. 80: 65-72. PMID 18505045 DOI: 10.3378/1534-6617(2008)80[65:Lbwaap]2.0.Co;2  0.287
2005 Musumeci L, Bongiorni C, Tautz L, Edwards RA, Osterman A, Perego M, Mustelin T, Bottini N. Low-molecular-weight protein tyrosine phosphatases of Bacillus subtilis. Journal of Bacteriology. 187: 4945-56. PMID 15995210 DOI: 10.1128/Jb.187.14.4945-4956.2005  0.287
2015 Bottini M, Bhattacharya K, Fadeel B, Magrini A, Bottini N, Rosato N. Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 26707894 DOI: 10.1016/J.Nano.2015.09.013  0.284
2007 Greco E, Bottini N, Canu G, Maccari AM, Saccucci P, Gloria-Bottini F, Fontana L. Skin testing correlates negatively with high-activity ACP1 *B/*C genotype International Archives of Allergy and Immunology. 145: 48-53. PMID 17703100 DOI: 10.1159/000107466  0.283
2010 Saccucci P, Meloni GF, Verrotti A, Borgiani P, D'Annibale F, Giannini C, Lucarelli P, Bottini N, Chiarelli F, Bottini E, Gloria-Bottini F. A study of three polymorphic sites of the ADA gene in children with type 1 diabetes mellitus. Journal of Pediatric Endocrinology & Metabolism : Jpem. 23: 283-90. PMID 20480728 DOI: 10.1515/Jpem.2010.23.3.283  0.282
2006 Gloria-Bottini F, Bottini N, Bottini E. Effect of ACP1*C on early life viability Human Biology. 78: 365-369. PMID 17216808 DOI: 10.1353/Hub.2006.0046  0.279
2004 Bottini N, Magrini A, Cosmi E, Gloria-Bottini F, Saccucci P, Di Iorio R, Bergamaschi A, Bottini E. Genetics of signal transduction and the effect of maternal smoking on sex ratio of offspring. American Journal of Human Biology : the Official Journal of the Human Biology Council. 16: 588-92. PMID 15368606 DOI: 10.1002/Ajhb.20058  0.278
2001 Bottini N, De Luca D, Saccucci P, Fiumara A, Elia M, Porfirio MC, Lucarelli P, Curatolo P. Autism: evidence of association with adenosine deaminase genetic polymorphism. Neurogenetics. 3: 111-3. PMID 11354825 DOI: 10.1007/S100480000104  0.278
2005 Bottini N, Gloria-Bottini F, Amante A, Saccucci P, Bottini E. Genetic polymorphism and Th1/Th2 orientation International Archives of Allergy and Immunology. 138: 328-333. PMID 16224193 DOI: 10.1159/000088872  0.277
2005 Iannaccone U, Bergamaschi A, Magrini A, Marino G, Bottini N, Lucarelli P, Bottini E, Gloria-Bottini F. Serum glucose concentration and ACP1 genotype in healthy adult subjects. Metabolism: Clinical and Experimental. 54: 891-4. PMID 15988697 DOI: 10.1016/J.Metabol.2005.02.002  0.275
2009 Lamsyah H, Rueda B, Baassi L, Elaouad R, Bottini N, Sadki K, Martin J. Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population Tissue Antigens. 74: 228-232. PMID 19563523 DOI: 10.1111/J.1399-0039.2009.01304.X  0.274
2002 Bottini N, MacMurray J, Peters W, Rostamkhani M, Comings DE. Association of the acid phosphatase (ACP1) gene with triglyceride levels in obese women. Molecular Genetics and Metabolism. 77: 226-9. PMID 12409270 DOI: 10.1016/S1096-7192(02)00120-8  0.273
2009 Banci M, Saccucci P, D'Annibale F, Dofcaci A, Trionfera G, Magrini A, Bottini N, Bottini E, Gloria-Bottini F. ACP1 genetic polymorphism and coronary artery disease: An association study Cardiology. 113: 236-242. PMID 19246900 DOI: 10.1159/000203405  0.273
2014 Bottini M, Sacchetti C, Pietroiusti A, Bellucci S, Magrini A, Rosato N, Bottini N. Targeted nanodrugs for cancer therapy: prospects and challenges. Journal of Nanoscience and Nanotechnology. 14: 98-114. PMID 24730253 DOI: 10.1166/Jnn.2014.9010  0.272
2018 Bhattacharya K, Sacchetti C, Costa PM, Sommertune J, Brandner BD, Magrini A, Rosato N, Bottini N, Bottini M, Fadeel B. Nitric Oxide Dependent Degradation of Polyethylene Glycol-Modified Single-Walled Carbon Nanotubes: Implications for Intra-Articular Delivery. Advanced Healthcare Materials. PMID 29334180 DOI: 10.1002/Adhm.201700916  0.271
2013 Sacchetti C, Motamedchaboki K, Magrini A, Palmieri G, Mattei M, Bernardini S, Rosato N, Bottini N, Bottini M. Surface polyethylene glycol conformation influences the protein corona of polyethylene glycol-modified single-walled carbon nanotubes: potential implications on biological performance. Acs Nano. 7: 1974-89. PMID 23413928 DOI: 10.1021/Nn400409H  0.271
2002 Magrini A, Bottini N, Nicotra M, Cosmi E, Bottini E, Bergamaschi A. Smoking and the genetics of signal transduction: an association study on retinopathy in type 1 diabetes. The American Journal of the Medical Sciences. 324: 310-3. PMID 12495297 DOI: 10.1097/00000441-200212000-00004  0.269
2005 Bottini N, Meloni GF, Lucarelli P, Amante A, Saccucci P, Gloria-Bottini F, Bottini E. Risk of type 1 diabetes in childhood and maternal age at delivery, interaction with ACPI and sex Diabetes/Metabolism Research and Reviews. 21: 353-358. PMID 15586390 DOI: 10.1002/Dmrr.521  0.268
1998 Lucarini N, Antonacci E, Bottini N, Borgiani P, Faggioni G, Gloria-Bottini F. Phosphotyrosine-protein-phosphatase and diabetic disorders. Further studies on the relationship between low molecular weight acid phosphatase genotype and degree of glycemic control Disease Markers. 14: 121-125. PMID 9868599 DOI: 10.1155/1998/145391  0.267
2014 Sacchetti C, Liu-Bryan R, Magrini A, Rosato N, Bottini N, Bottini M. Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes. Acs Nano. 8: 12280-91. PMID 25415768 DOI: 10.1021/Nn504537B  0.264
2005 Bottini N, Stefanini L, Lucarelli P, Bottini E. Adaptation to past malarial endemia and susceptibility to common diseases in modern populations: A study of adenosine deaminase and MN blood group genetic polymorphisms American Journal of Physical Anthropology. 128: 194-198. PMID 15761857 DOI: 10.1002/Ajpa.20019  0.263
2016 Doody KM, Bottini N. Chondrocyte clocks make cartilage time-sensitive material. The Journal of Clinical Investigation. 126: 38-9. PMID 26657854 DOI: 10.1172/Jci85632  0.261
2002 Faggioni G, Borgiani P, Bottini N, Gloria-Bottini F, Tontoli F, Contreas V, Bottini E, Lista F. Identification of two SNPs in the 5′ flanking region of the ACP1 gene and evaluation of disequilibrium among polymorphic sites Annals of Human Genetics. 66: 245-254. PMID 12418966 DOI: 10.1017/S0003480002001136  0.26
2012 Teruel M, Martin J, Ortego-Centeno N, Jiménez Alonso J, Sánchez-Román J, de Ramón E, Francisca Gonzalez-Escribano M, Pons-Estel BA, D’Alfonso S, Sebastiani GD, Witte T, Bottini N, González-Gay MA, Alarcón-Riquelme ME, Martin J. Erratum to “Novel association of acid phosphatase locus 1*C allele with systemic lupus erythematosus” [Human Immunology 73 (2012) 107–110] Human Immunology. 73: 984. DOI: 10.1016/J.Humimm.2012.07.002  0.258
2001 Ronchetti F, Villa MP, Ronchetti R, Bonci E, Latini L, Pascone R, Bottini N, Gloria-Bottini F. ABO/Secretor genetic complex and susceptibility to asthma in childhood European Respiratory Journal. 17: 1236-1238. PMID 11491170 DOI: 10.1183/09031936.01.99109101  0.256
2012 Bottini M, Bottini N. Modified carbon nanotubes: From nanomedicine to nanotoxicology Proceedings of Spie - the International Society For Optical Engineering. 8462. DOI: 10.1117/12.931232  0.256
2008 Rapini N, Duca ED, Bottini N, Saccucci P, Piccinini S, Porcari M, Arcano S, Angelini F, Luisa Manca Bitti M. Sa.72. Defective Dendritic Cell Function in Children with Type 1 Diabetes Heterozygous for the PTPN22 C1858T Polymorphism Clinical Immunology. 127: S104. DOI: 10.1016/J.Clim.2008.03.293  0.254
2004 Saccucci P, Verdecchia M, Piciullo A, Bottini N, Rizzo R, Gloria-Bottini F, Lucarelli P, Curatolo P. Convulsive disorder and genetic polymorphism. Association of idiopathic generalized epilepsy with haptoglobin polymorphism Neurogenetics. 5: 245-248. PMID 15490286 DOI: 10.1007/S10048-004-0192-1  0.25
2007 Gloria-Bottini F, Bottini N. The link between obesity and allergy: A role of ACP1 genetic polymorphism? [3] International Journal of Obesity. 31: 392-393. PMID 16770334 DOI: 10.1038/Sj.Ijo.0803396  0.248
2004 Bottini N, Gloria-Bottini F, Magrini A, Stefanini L, Cosmi E, Bergamaschi A, Cosmi EV, Bottini E. Maternal cigarette smoking, metabolic enzyme polymorphism, and developmental events in the early stages of extrauterine life Human Biology. 76: 289-297. PMID 15359537 DOI: 10.1353/Hub.2004.0029  0.243
2008 Gloria-Bottini F, Bottini N, La Torre M, Magrini A, Bergamaschi A, Bottini E. The effects of genetic and seasonal factors on reproductive success. Fertility and Sterility. 89: 1090-4. PMID 17678914 DOI: 10.1016/J.Fertnstert.2007.04.030  0.237
1997 Bottini N, Fontana L. Tyrosine-phosphatase and signal transduction in immune-mediated diseases. Possible role of the genetic variability of cLMWPTPase | TIROSIN-FOSFATASI E TRASDUZIONE DEL SEGNALE. POSSIBILE RUOLO DELLA VARIABILITA GENETICA DELLA cLMWPTPase NELLE MALATTIE DEL SISTEMA IMMUNE Eos Rivista Di Immunologia Ed Immunofarmacologia. 17: 37-41.  0.236
2008 Gloria-Bottini F, Meloni GF, Nicotra M, Saccucci P, Stampone L, Bottini N, Lista F, Bottini E. Feto-maternal ACP1 activity ratio and intrauterine survival. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 140: 12-6. PMID 16762482 DOI: 10.1016/J.Ejogrb.2006.03.025  0.233
2006 Liu Y, Saccucci P, Qi H, Wu HC, Zhao F, Dai Y, Bottini N, Gloria-Bottini F. ADA polymorphisms and asthma: A study in the Chinese Han population Journal of Asthma. 43: 203-206. PMID 16754522 DOI: 10.1080/02770900600566827  0.232
2011 Bottini M, Rosato N, Bottini N. PEG-modified carbon nanotubes in biomedicine: current status and challenges ahead. Biomacromolecules. 12: 3381-93. PMID 21916410 DOI: 10.1021/Bm201020H  0.232
2003 Bottini N, Otsu A, Borgiani P, Saccucci P, Stefanini L, Greco E, Fontana L, Hopkins JM, Mao XQ, Shirakawa T. Genetic control of serum IgE levels: A study of low molecular weight protein tyrosine phosphatase Clinical Genetics. 63: 228-231. PMID 12694235 DOI: 10.1034/j.1399-0004.2003.00002.x  0.231
2002 Bottini N, Ammendola M, Gloria-Bottini F. ACP1 is associated with allergy Allergy: European Journal of Allergy and Clinical Immunology. 57: 651-652. PMID 12100313 DOI: 10.1034/J.1398-9995.2002.23722.X  0.23
2003 Magrini A, Bottini N, Gloria-Bottini F, Stefanini L, Bergamaschi A, Cosmi E, Bottini E. Enzyme polymorphisms, smoking, and human reproduction. A study of human placental alkaline phosphatase American Journal of Human Biology. 15: 781-785. PMID 14595869 DOI: 10.1002/Ajhb.10213  0.229
2023 McBride DA, Kerr MD, Johnson WT, Nguyen A, Zoccheddu M, Yao M, Prideaux EB, Dorn NC, Wang W, Svensson MND, Bottini N, Shah NJ. Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2202720. PMID 36890657 DOI: 10.1002/advs.202202720  0.228
2005 Gloria-Bottini F, Bottini N, Cosmi E, Cosmi EV, Bottini E. The effect of gender and ACP1 genetic polymorphism on the correlation between birth weight and placental weight Placenta. 26: 846-848. PMID 16226135 DOI: 10.1016/J.Placenta.2004.12.002  0.228
2002 Bottini N, Ronchetti F, Gloria-Bottini F. Cooperative effect of adenosine deaminase and ABO-secretor genetic complex on susceptibility to childhood asthma [2] European Respiratory Journal. 20: 1613-1615. PMID 12503725 DOI: 10.1183/09031936.02.00062302  0.227
2001 Bottini N, Meloni GF, Finocchi A, Ruggiu G, Amante A, Meloni T, Bottini E. Maternal-fetal interaction in the ABO system: A comparative analysis of healthy mothers and couples with recurrent spontaneous abortion suggests a protective effect of B incompatibility Human Biology. 73: 167-174. PMID 11446422 DOI: 10.1353/Hub.2001.0016  0.226
2005 Bottini N, Ronchetti F, Gloria-Bottini F, Stefanini L, Bottini E, Lucarini N. Atopic and nonatopic asthma in children Journal of Asthma. 42: 25-28. PMID 15801324 DOI: 10.1081/Jas-200044756  0.226
2009 Banci M, Saccucci P, D'Annibale F, Dofcaci A, Trionfera G, Magrini A, Bottini N, Bottini E, Gloria-Bottini F. Adenosine deaminase genetic polymorphism and coronary artery disease. Cardiology. 112: 74-5. PMID 18560234 DOI: 10.1159/000139954  0.222
2022 McBride DA, Dorn NC, Yao M, Johnson WT, Wang W, Bottini N, Shah NJ. Short-chain fatty acid-mediated epigenetic modulation of inflammatory T cells in vitro. Drug Delivery and Translational Research. PMID 36566262 DOI: 10.1007/s13346-022-01284-6  0.221
2007 Gloria-Bottini F, Meloni GF, Grassi S, Bottini N, Saccucci P, Giarrizzo GF, Magrini A, Bergamaschi A, Bottini E. ACP1 and offspring sex ratio in smoking puerperae: A study at population level Early Human Development. 83: 349-354. PMID 16973312 DOI: 10.1016/J.Earlhumdev.2006.07.005  0.221
2024 McBride DA, Wang JS, Johnson WT, Bottini N, Shah NJ. ABCD of IA: A multi-scale agent-based model of T cell activation in inflammatory arthritis. Biomaterials Science. PMID 38349277 DOI: 10.1039/d3bm01674a  0.219
1998 Nicotra M, Bottini N, Grasso M, Gimelfarb A, Lucarini N, Cosmi E, Bottini E. Adenosine deaminase and human reproduction: a comparative study of fertile women and women with recurrent spontaneous abortion. American Journal of Reproductive Immunology (New York, N.Y. : 1989). 39: 266-70. PMID 9553651 DOI: 10.1111/J.1600-0897.1998.Tb00363.X  0.219
2006 Bottini M, Bruckner S, Nika K, Bottini N, Bellucci S, Magrini A, Bergamaschi A, Mustelin T. Multi-walled carbon nanotubes induce T lymphocyte apoptosis. Toxicology Letters. 160: 121-6. PMID 16125885 DOI: 10.1016/J.Toxlet.2005.06.020  0.214
1999 Bottini N, Gimelfarb A, Gloria-Bottini F. Haptoglobin genotype and natural fertility in humans Fertility and Sterility. 72: 293-296. PMID 10438998 DOI: 10.1016/S0015-0282(99)00210-1  0.214
2022 Hurysz B, Bottini N. Emerging proteoglycans and proteoglycan-targeted therapies in rheumatoid arthritis. American Journal of Physiology. Cell Physiology. PMID 35476502 DOI: 10.1152/ajpcell.00086.2022  0.213
2023 Sendo S, Kiosses WB, Yang S, Wu DJ, Lee DWK, Liu L, Aschner Y, Vela AJ, Downey GP, Santelli E, Bottini N. Clustering of phosphatase RPTPα promotes Src signaling and the arthritogenic action of synovial fibroblasts. Science Signaling. 16: eabn8668. PMID 37402225 DOI: 10.1126/scisignal.abn8668  0.21
2007 Bottini E, Bergamaschi A, Magrini A, Spina C, Ammendola L, Grassi S, Bottini N, Gloria-Bottini F. Allergy and ACP1 genetic polymorphism. Allergy and Asthma Proceedings : the Official Journal of Regional and State Allergy Societies. 28: 87-92. PMID 17390764 DOI: 10.2500/aap.2007.28.2916  0.209
2002 Bottini N, Magrini A, Macmurray J, Cosmi E, Nicotra M, Gloria-Bottini F, Bergamaschi A. Smoking, haptoglobin and fertility in humans. Tobacco Induced Diseases. 1: 3-6. PMID 19570244 DOI: 10.1186/1617-9625-1-1-3  0.209
1999 Huang SW, Bottini N, Fontana L. Asthma and diabetes (multiple letters) [9] Lancet. 354: 515-516. PMID 10465205 DOI: 10.1016/S0140-6736(05)75552-5  0.208
2023 Johnson WT, McBride D, Kerr M, Nguyen A, Zoccheddu M, Bollmann M, Wei X, Jones RM, Wang W, Svensson MND, Bottini N, Shah NJ. Immunomodulatory Nanoparticles for Modulating Arthritis Flares. Acs Nano. PMID 38016062 DOI: 10.1021/acsnano.3c05298  0.208
2003 Lucarelli P, Palminiello S, Saccucci P, Bottini N, De Luca D, Elia M, Fiumara A, Curatolo P. Association study of autistic disorder and chromosome 16p. American Journal of Medical Genetics. Part A. 119: 242-6. PMID 12749074 DOI: 10.1002/Ajmg.A.10187  0.204
2003 Meloni G, Bottini N, Borgiani P, Lucarelli P, Meloni T, Bottini E. Association of the ACP1 genotype with metabolic parameters upon initial diagnosis of type 1 diabetes. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 9: CR105-8. PMID 12640337  0.203
1996 Antonacci E, Bottini N, Faggioni G, Lucarini N. Neuropathy Clustering in Diabetes International Journal of Immunopathology and Pharmacology. 9: 74-75. DOI: 10.1177/039463209600900248  0.202
2002 Lucarelli P, Saccucci P, Bottini N, De Luca D, Fiumara A, Elia M, Bottini N, Porfirio MC, Curatolo P. Two-loci ADA haplotypes in autistic disorder. American Journal of Medical Genetics. 108: 339-40. PMID 11920843 DOI: 10.1002/Ajmg.10272  0.202
1999 Bottini N, Lucarini N, Nicotra M, Gloria-Bottini F. A marker locus for fertility?-- Real or spurious? Fertility and Sterility. 72: 1148-9. PMID 10593401 DOI: 10.1016/S0015-0282(99)00433-1  0.202
2000 Bottini N, Dituri F, Gloria-Bottini F. Season of birth and early neonatal events. The rise of serum bilirubin Biological Rhythm Research. 31: 50-55. DOI: 10.1076/0929-1016(200002)31:1;1-0;Ft050  0.201
2009 Renzetti G, Silvestre G, D'Amario C, Bottini E, Gloria-Bottini F, Bottini N, Auais A, Perez MK, Piedimonte G. Less air pollution leads to rapid reduction of airway inflammation and improved airway function in asthmatic children. Pediatrics. 123: 1051-8. PMID 19255039 DOI: 10.1542/Peds.2008-1153  0.2
2009 Renzetti G, Silvestre G, D'Amario C, Bottini E, Gloria-Bottini F, Bottini N, Auais A, Perez MK, Piedimonte G. Less air pollution leads to rapid reduction of airway inflammation and improved airway function in asthmatic children (Pediatrics (2009) 123, 3, (1051-1058)) Pediatrics. 124: 1000. DOI: 10.1542/Peds.2009-1632  0.198
2002 Bottini N, Bottini E, Gloria-Bottini F, Mustelin T. Low-molecular-weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms. Archivum Immunologiae Et Therapiae Experimentalis. 50: 95-104. PMID 12022706  0.198
2015 Bottini N, Firestein GS. Decade in review-translational rheumatology: Ten years after: rheumatology research from bench to bedside. Nature Reviews. Rheumatology. 11: 623-4. PMID 26390844 DOI: 10.1038/Nrrheum.2015.126  0.197
2005 Bottini M, Tautz L, Huynh H, Monosov E, Bottini N, Dawson MI, Bellucci S, Mustelin T. Covalent decoration of multi-walled carbon nanotubes with silica nanoparticles. Chemical Communications (Cambridge, England). 758-60. PMID 15685328 DOI: 10.1039/B412876A  0.196
1999 Bottini N, Ronchetti MP, Gloria-Bottini F, Fontana L. Malaria as a possible evolutionary cause of allergy Allergy: European Journal of Allergy and Clinical Immunology. 54: 188-189. PMID 10221447 DOI: 10.1034/J.1398-9995.1999.00061.X  0.187
2001 Bottini N, Meloni G, Porcu S, Gloria-Bottini F. Cyclic seasonal variation of G-6-PD deficiency in newborn infants from Sardinia Biological Rhythm Research. 32: 413-421. DOI: 10.1076/Brhm.32.4.413.1330  0.185
1997 Lucarini N, Bottini N, Antonacci E, Borgiani P, Faggioni G, Gloria-Bottin F. Diabetic complications and the genetics of signal transduction. A study of retinopathy in NIDDM Disease Markers. 13: 169-176. PMID 9405929  0.176
2005 Yuan M, Deleuil F, Fällman M, Herro R, Cossart P, Buchrieser C, Gouin E, Glaser P, Deutscher J, Echols N, Lombana TN, Miecskowski CA, Pullen KE, Sung P, Alber T, ... ... Bottini N, et al. Subject Index Vol. 9, 2005 Journal of Molecular Microbiology and Biotechnology. 9: 238-238. DOI: 10.1159/000091039  0.171
2000 Bottini N, Ronchetti F, Villa MP. MN blood groups and asthma onset Lancet. 356: 506. PMID 10981912 DOI: 10.1016/S0140-6736(05)74175-1  0.171
2024 McBride DA, Jones RM, Bottini N, Shah NJ. The therapeutic potential of immunoengineering for systemic autoimmunity. Nature Reviews. Rheumatology. PMID 38383732 DOI: 10.1038/s41584-024-01084-x  0.166
2005 Yuan M, Deleuil F, Fällman M, Herro R, Cossart P, Buchrieser C, Gouin E, Glaser P, Deutscher J, Echols N, Lombana TN, Miecskowski CA, Pullen KE, Sung P, Alber T, ... ... Bottini N, et al. Contents Vol. 9, 2005 Journal of Molecular Microbiology and Biotechnology. 9: 239-240. DOI: 10.1159/000091040  0.164
2023 Bottini A, Pacheco DRDCG, Forti FL, Bottini N. Revisiting VH1 phosphatase at the time of monkeypox: back to the spotlight. Biochemical Society Transactions. PMID 37409507 DOI: 10.1042/BST20200408  0.162
2024 Van Espen B, Prideaux EB, Wilson AR, Machado CRL, Sendo S, Parker J, Seumois G, Sacchetti C, Belongia AC, Perumal NB, Vijayanand P, Linnik MD, Benschop RJ, Wang W, Bottini N, et al. Laser capture microscopy (LCM)-RNAseq for topological mapping of synovial pathology during rheumatoid arthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 38556917 DOI: 10.1002/art.42853  0.161
2000 Greene LS, Bottini N, Borgiani P, Gloria-Bottini F. Acid phosphatase locus 1 (ACP1): Possible relationship of allelic variation to body size and human population adaptation to thermal stress - A theoretical perspective American Journal of Human Biology. 12: 688-701.  0.16
2021 Johnson WT, Dorn NC, Ogbonna DA, Bottini N, Shah NJ. Lipid-based regulators of immunity. Bioengineering & Translational Medicine. 7: e10288. PMID 35600637 DOI: 10.1002/btm2.10288  0.149
2023 Shah NJ, Bottini N. Inhibiting the Inhibitor in Synovial Macrophages and Cancer Immunotherapy-Associated Inflammatory Arthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 37909274 DOI: 10.1002/art.42743  0.145
2009 Saccucci P, Manca Bitti ML, Bottini N, Rapini N, Piccinini S, D'Annibale F, Chiarelli F, Verrotti A, Bottini E, Gloria-Bottini F. Type 1 diabetes: evidence of interaction between ACP1 and ADA1 gene polymorphisms. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 15: CR511-517. PMID 19789510  0.143
2009 Greco E, Gloria-Bottini F, Canu G, Maccari AM, Bottini E, Liu Y, Bottini N, Perricone R, Fontana L. ADA genetic polymorphism and total plasma IgE level in healthy adults Italian Journal of Allergy and Clinical Immunology. 19: 158-161.  0.143
1997 Lucarini N, Antonacci E, Bottini N, Bottini FG. Low-molecular-weight acid phosphatase (ACP1), obesity, and blood lipid levels in subjects with non-insulin-dependent diabetes mellitus Human Biology. 69: 509-515. PMID 9198310  0.131
2022 Zhang R, Kumar GS, Hansen U, Zoccheddu M, Sacchetti C, Holmes ZJ, Lee MC, Beckmann D, Wen Y, Mikulski Z, Yang S, Santelli E, Page R, Boin F, Peti W, ... Bottini N, et al. Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex. Jci Insight. 7. PMID 35451370 DOI: 10.1172/jci.insight.155761  0.129
2000 Gloria-Bottini F, Antonacci E, Bottini N, Ogana A, Borgiani P, De Santis G, Lucarini N. RH blood groups and diabetic disorders: Is there an effect on glycosylated hemoglobin level? Human Biology. 72: 287-294. PMID 10803660  0.126
2002 Bottini N, Borgiani P, Otsu A, Saccucci P, Stefanini L, Greco E, Fontana L, Hopkin JM, Mao XQ, Shirakawa T. IL-4 receptor alpha chain genetic polymorphism and total IgE levels in the English population: Two-locus haplotypes are more informative than individuals SNPs Clinical Genetics. 61: 288-292. PMID 12030894 DOI: 10.1034/j.1399-0004.2002.610408.x  0.125
1996 Lucarini N, Antonacci E, Bottini N, Gloria-Bottini F. Low molecular weight acid phosphatase and obesity. the pattern of association in non-insulin-dependent diabetes mellitus Journal of Investigative Medicine. 44: 326a.  0.115
2006 Gloria-Bottini F, Ronchetti F, Ammendola L, Bottini N. Adenosine deaminase polymorphism and the relationship of total immunoglobulin E with skin prick test: a study on school children. Allergy and Asthma Proceedings : the Official Journal of Regional and State Allergy Societies. 27: 115-8. PMID 16724628  0.113
2003 Curatolo P, Verdecchia M, Bombardieri R, Bottini N. Neurologic phenotypes in tuberous sclerosis complex Paediatria Croatica. 47: 69-72.  0.11
2013 Bottini M, Sacchetti C, Rapini N, Rosato N, Magrini A, Bottini N. Nanosystem for targeting Treg in vivo Technical Proceedings of the 2013 Nsti Nanotechnology Conference and Expo, Nsti-Nanotech 2013. 3: 300-303.  0.109
2003 Bottini M, Magrini A, Bottini N, Bergamaschi A. Nanotubes and fullerenes: An overview of the possible environmental and biological impact of bio-nanotechnologies | Nanotubi e fullereni: Attuali vedute sul possibile impatto ambientale e biologico delle bio-nanotecnologie Medicina Del Lavoro. 94: 497-505. PMID 14768242  0.077
2000 Gao PS, Fujishima S, Mao XQ, Remus N, Kanda M, Enomoto T, Dake Y, Bottini N, Tabuchi M, Hasegawa N, Yamaguchi K, Tiemessen C, Hopkin JM, Shirakawa T, Kishi F. Genetic variants of NRAMP1 and active tuberculosis in Japanese populations. International Tuberculosis Genetics Team. Clinical Genetics. 58: 74-6. PMID 10945666 DOI: 10.1034/j.1399-0004.2000.580113.x  0.075
2011 Kowalski P, Bottini N. Comparative advantage and export specialisation mobility Globalisation, Comparative Advantage and the Changing Dynamics of Trade. 2147483647: 81-119. DOI: 10.1787/9789264113084-5-en  0.042
1979 Bottini N, Nash P. Automated air information production system. Phase I. Volume I. Executive summary 0.027
2011 Bottini N, Marouani MA, Munro L. Service sector restrictiveness and economic performance: An estimation for the MENA region World Economy. 34: 1652-1678. DOI: 10.1111/j.1467-9701.2011.01337.x  0.027
2010 Molnár M, Bottini N. How large are competitive pressures in services markets? Estimation of mark-ups for selected OECD countries Oecd Journal: Economic Studies. 149-199.  0.022
2007 Bottini N. First impressions Strad. 118: 40.  0.017
2009 Kowalski P, Lattimore R, Bottini N. South Africa Globalisation and Emerging Economies: Brazil, Russia, India, Indonesia, China and South Africa. 2147483647: 397-453. DOI: 10.1787/9789264044814-13-en  0.012
2014 Bottini N, Gasiorek M. Young, small and export oriented: The Moroccan winners? Innovation Globalization and Firm Dynamics: Lessons For Enterprise Policy. 161-176. DOI: 10.4324/9781315816302  0.01
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