John K. Northup - Publications

Affiliations: 
University of Virginia, Charlottesville, VA 

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Soubias O, Nickels JD, Yeliseev A, Hines KG, Teague WE, Northup J, Katsaras J, Gawrisch K. G Protein-GPCR Interaction Studied by SANS Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.3810  0.372
2014 Bhattacharyya N, Hu X, Chen CZ, Mathews Griner LA, Zheng W, Inglese J, Austin CP, Marugan JJ, Southall N, Neumann S, Northup JK, Ferrer M, Collins MT. A high throughput screening assay system for the identification of small molecule inhibitors of gsp. Plos One. 9: e90766. PMID 24667240 DOI: 10.1371/Journal.Pone.0090766  0.33
2014 Soubias O, Northup JK, Hines KG, Teague WE, Gawrisch K. Rhodopsin Crowding in Model Lipid Bilayers - Functional Implications Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.3955  0.318
2013 Randazzo PA, Jian X, Chen PW, Zhai P, Soubias O, Northup JK. Quantitative Analysis of Guanine Nucleotide Exchange Factors (GEFs) as Enzymes. Cellular Logistics. 3: e27609. PMID 25332840 DOI: 10.4161/Cl.27609  0.427
2012 Northup JK, Jian X, Randazzo PA. Nucleotide exchange factors: Kinetic analyses and the rationale for studying kinetics of GEFs. Cellular Logistics. 2: 140-146. PMID 23181196 DOI: 10.4161/Cl.21627  0.405
2012 Rebois RV, Maki K, Meeks JA, Fishman PH, Hébert TE, Northup JK. D2-like dopamine and β-adrenergic receptors form a signaling complex that integrates Gs- and Gi-mediated regulation of adenylyl cyclase. Cellular Signalling. 24: 2051-60. PMID 22759790 DOI: 10.1016/J.Cellsig.2012.06.011  0.365
2012 Inagaki S, Ghirlando R, White JF, Gvozdenovic-Jeremic J, Northup JK, Grisshammer R. Modulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipid. Journal of Molecular Biology. 417: 95-111. PMID 22306739 DOI: 10.1016/J.Jmb.2012.01.023  0.377
2012 Zhuang X, Northup JK, Ray K. Large putative PEST-like sequence motif at the carboxyl tail of human calcium receptor directs lysosomal degradation and regulates cell surface receptor level. The Journal of Biological Chemistry. 287: 4165-76. PMID 22158862 DOI: 10.1074/Jbc.M111.271528  0.326
2011 Lyon AM, Tesmer VM, Dhamsania VD, Thal DM, Gutierrez J, Chowdhury S, Suddala KC, Northup JK, Tesmer JJ. An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation. Nature Structural & Molecular Biology. 18: 999-1005. PMID 21822282 DOI: 10.1038/Nsmb.2095  0.371
2010 Zhuang X, Adipietro KA, Datta S, Northup JK, Ray K. Rab1 small GTP-binding protein regulates cell surface trafficking of the human calcium-sensing receptor. Endocrinology. 151: 5114-23. PMID 20861236 DOI: 10.1210/En.2010-0422  0.348
2010 Zhuang X, Chowdhury S, Northup JK, Ray K. Sar1-dependent trafficking of the human calcium receptor to the cell surface. Biochemical and Biophysical Research Communications. 396: 874-80. PMID 20457124 DOI: 10.1016/J.Bbrc.2010.05.014  0.331
2007 White JF, Grodnitzky J, Louis JM, Trinh LB, Shiloach J, Gutierrez J, Northup JK, Grisshammer R. Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interaction. Proceedings of the National Academy of Sciences of the United States of America. 104: 12199-204. PMID 17620610 DOI: 10.1073/Pnas.0705312104  0.436
2007 Sainz E, Cavenagh MM, LopezJimenez ND, Gutierrez JC, Battey JF, Northup JK, Sullivan SL. The G-protein coupling properties of the human sweet and amino acid taste receptors. Developmental Neurobiology. 67: 948-59. PMID 17506496 DOI: 10.1002/Dneu.20403  0.399
2007 Sainz E, Cavenagh MM, Gutierrez J, Battey JF, Northup JK, Sullivan SL. Functional characterization of human bitter taste receptors. The Biochemical Journal. 403: 537-43. PMID 17253962 DOI: 10.1042/Bj20061744  0.386
2007 Ray K, Adipietro KA, Chen C, Northup JK. Elucidation of the role of peptide linker in calcium-sensing receptor activation process. The Journal of Biological Chemistry. 282: 5310-7. PMID 17189274 DOI: 10.1074/Jbc.M609610200  0.368
2006 Engel S, Neumann S, Kaur N, Monga V, Jain R, Northup J, Gershengorn MC. Low affinity analogs of thyrotropin-releasing hormone are super-agonists. The Journal of Biological Chemistry. 281: 13103-9. PMID 16551618 DOI: 10.1074/Jbc.M600440200  0.389
2006 Saidak Z, Blake-Palmer K, Hay DL, Northup JK, Glass M. Differential activation of G-proteins by mu-opioid receptor agonists. British Journal of Pharmacology. 147: 671-80. PMID 16415903 DOI: 10.1038/Sj.Bjp.0706661  0.407
2006 Hébert TE, Northup JK, Rebois RV. Signal Transduction Mediated by Heptahelical Receptors and Heterotrimeric G Proteins Reviews in Cell Biology and Molecular Medicine. DOI: 10.1002/3527600906.Mcb.200500035  0.411
2005 Ray K, Tisdale J, Dodd RH, Dauban P, Ruat M, Northup JK. Calindol, a positive allosteric modulator of the human Ca(2+) receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+). The Journal of Biological Chemistry. 280: 37013-20. PMID 16135510 DOI: 10.1074/Jbc.M506681200  0.338
2004 Okada M, Goldman D, Linnoila M, Iwata N, Ozaki N, Northup JK. Comparison of G-protein selectivity of human 5-HT2C and 5-HT1A receptors. Annals of the New York Academy of Sciences. 1025: 570-7. PMID 15542764 DOI: 10.1196/Annals.1316.070  0.406
2004 Ray K, Ghosh SP, Northup JK. The role of cysteines and charged amino acids in extracellular loops of the human Ca(2+) receptor in cell surface expression and receptor activation processes. Endocrinology. 145: 3892-903. PMID 15117879 DOI: 10.1210/En.2003-1653  0.311
2004 Northup J. Measuring Rhodopsin-G-Protein Interactions by Surface Plasmon Resonance Methods of Molecular Biology. 261: 93-111. PMID 15064451 DOI: 10.1385/1-59259-762-9:093  0.438
2002 Rebois RV, Schuck P, Northup JK. Elucidating kinetic and thermodynamic constants for interaction of G protein subunits and receptors by surface plasmon resonance spectroscopy. Methods in Enzymology. 344: 15-42. PMID 11771379 DOI: 10.1016/S0076-6879(02)44703-9  0.363
2001 Jian X, Clark WA, Kowalak J, Markey SP, Simonds WF, Northup JK. Gbetagamma affinity for bovine rhodopsin is determined by the carboxyl-terminal sequences of the gamma subunit. The Journal of Biological Chemistry. 276: 48518-25. PMID 11602594 DOI: 10.1074/Jbc.M107129200  0.318
2001 Clark WA, Jian X, Chen L, Northup JK. Independent and synergistic interaction of retinal G-protein subunits with bovine rhodopsin measured by surface plasmon resonance. Biochemical Journal. 358: 389-397. PMID 11513737 DOI: 10.1042/0264-6021:3580389  0.408
1999 Glass M, Northup JK. Agonist Selective Regulation of G Proteins by Cannabinoid CB1 and CB2 Receptors Molecular Pharmacology. 56: 1362-1369. PMID 10570066 DOI: 10.1124/Mol.56.6.1362  0.442
1999 Donohue PJ, Sainz E, Akeson M, Kroog GS, Mantey SA, Battey JF, Jensen RT, Northup JK. An aspartate residue at the extracellular boundary of TMII and an arginine residue in TMVII of the gastrin-releasing peptide receptor interact to facilitate heterotrimeric G protein coupling. Biochemistry. 38: 9366-72. PMID 10413511 DOI: 10.1021/Bi990544H  0.346
1999 Jian X, Sainz E, Clark WA, Jensen RT, Battey JF, Northup JK. The bombesin receptor subtypes have distinct G protein specificities. Journal of Biological Chemistry. 274: 11573-11581. PMID 10206964 DOI: 10.1074/Jbc.274.17.11573  0.306
1998 Liu W, Clark WA, Sharma P, Northup JK. Mechanism of allosteric regulation of the rod cGMP phosphodiesterase activity by the helical domain of transducin alpha subunit. The Journal of Biological Chemistry. 273: 34284-92. PMID 9852093 DOI: 10.1074/Jbc.273.51.34284  0.398
1998 Liu W, Northup JK. The helical domain of a G protein α subunit is a regulator of its effector Proceedings of the National Academy of Sciences of the United States of America. 95: 12878-12883. PMID 9789008 DOI: 10.1073/Pnas.95.22.12878  0.388
1997 Hellmich MR, Battey JF, Northup JK. Selective reconstitution of gastrin-releasing peptide receptor with Gαq Proceedings of the National Academy of Sciences of the United States of America. 94: 751-756. PMID 9012857 DOI: 10.1073/Pnas.94.2.751  0.404
1996 Hartman JL, Northup JK. Functional reconstitution in situ of 5-hydroxytryptamine2c (5HT2c) receptors with alphaq and inverse agonism of 5HT2c receptor antagonists. The Journal of Biological Chemistry. 271: 22591-7. PMID 8798428 DOI: 10.1074/Jbc.271.37.22591  0.412
1995 Mitchell J, Gutierrez J, Northup JK. Purification, Characterization, and Partial Amino Acid Sequence of a G Protein-activated Phospholipase C from Squid Photoreceptors Journal of Biological Chemistry. 270: 854-859. PMID 7822322 DOI: 10.1074/Jbc.270.2.854  0.452
1991 Tamir H, Fawzi AB, Tamir A, Evans T, Northup JK. G-protein beta gamma forms: identity of beta and diversity of gamma subunits. Biochemistry. 30: 3929-36. PMID 1902114 DOI: 10.1021/Bi00230A018  0.326
1991 Randazzo PA, Northup JK, Kahn RA. Activation of a small GTP-binding protein by nucleoside diphosphate kinase Science. 254: 850-853. PMID 1658935 DOI: 10.1126/SCIENCE.1658935  0.421
1990 Fawzi AB, Northup JK. Guanine nucleotide binding characteristics of transducin: essential role of rhodopsin for rapid exchange of guanine nucleotides. Biochemistry. 29: 3804-12. PMID 2187531 DOI: 10.1021/BI00467A030  0.326
1990 Gautam N, Northup J, Tamir H, Simon MI. G protein diversity is increased by associations with a variety of gamma subunits. Proceedings of the National Academy of Sciences of the United States of America. 87: 7973-7. PMID 2122451 DOI: 10.1073/Pnas.87.20.7973  0.412
1989 Blay J, Valentine-Braun KA, Northup JK, Hollenberg MD. Epidermal-growth-factor-stimulated phosphorylation of calpactin II in membrane vesicles shed from cultured A-431 cells. The Biochemical Journal. 259: 577-83. PMID 2524190 DOI: 10.1042/Bj2590577  0.33
1988 Northup JK, Valentine-Braun KA, Johnson LK, Severson DL, Hollenberg MD. Evaluation of the antiinflammatory and phospholipase-inhibitory activity of calpactin II/lipocortin I. The Journal of Clinical Investigation. 82: 1347-52. PMID 2971676 DOI: 10.1172/Jci113737  0.329
1988 Valentine-Braun KA, Hollenberg MD, Fraser E, Northup JK. Isolation of a major human placental substrate for the epidermal growth factor (urogastrone) receptor kinase: immunological cross-reactivity with transducin and sequence homology with lipocortin. Archives of Biochemistry and Biophysics. 259: 262-82. PMID 2962537 DOI: 10.1016/0003-9861(87)90494-2  0.337
1988 Logothetis DE, Kim DH, Northup JK, Neer EJ, Clapham DE. Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 85: 5814-8. PMID 2457901 DOI: 10.1073/Pnas.85.16.5814  0.321
1987 Waldo GL, Evans T, Fraser ED, Northup JK, Martin MW, Harden TK. Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go Biochemical Journal. 246: 431-439. PMID 3120696 DOI: 10.1042/bj2460431  0.302
1986 Valentine-Braun KA, Northup JK, Hollenberg MD. Epidermal growth factor (urogastrone)-mediated phosphorylation of a 35-kDa substrate in human placental membranes: relationship to the beta subunit of the guanine nucleotide regulatory complex. Proceedings of the National Academy of Sciences of the United States of America. 83: 236-40. PMID 3079907 DOI: 10.1073/Pnas.83.2.236  0.391
1985 Broek D, Samiy N, Fasano O, Fujiyama A, Tamanoi F, Northup J, Wigler M. Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins. Cell. 41: 763-9. PMID 3891097 DOI: 10.1016/S0092-8674(85)80057-X  0.318
1984 Katada T, Northup JK, Bokoch GM, Ui M, Gilman AG. The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition. Journal of Biological Chemistry. 259: 3578-3585. DOI: 10.1016/s0021-9258(17)43133-4  0.562
1984 Katada T, Bokoch GM, Northup JK, Ui M, Gilman AG. The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein. Journal of Biological Chemistry. 259: 3568-3577. DOI: 10.1016/s0021-9258(17)43132-2  0.612
1984 Bokoch GM, Katada T, Northup JK, Ui M, Gilman AG. Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Journal of Biological Chemistry. 259: 3560-3567. DOI: 10.1016/s0021-9258(17)43131-0  0.582
1983 Bokoch GM, Katada T, Northup JK, Hewlett EL, Gilman AG. Identification of the predominant substrate for ADP-ribosylation by islet activating protein. Journal of Biological Chemistry. 258: 2072-2075. DOI: 10.1016/s0021-9258(18)32881-3  0.536
1983 Northup JK, Smigel MD, Sternweis PC, Gilman AG. The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit. Journal of Biological Chemistry. 258: 11369-11376. DOI: 10.1016/s0021-9258(17)44427-9  0.603
1983 Northup JK, Sternweis PC, Gilman AG. The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit. Journal of Biological Chemistry. 258: 11361-11368. DOI: 10.1016/s0021-9258(17)44426-7  0.614
1982 Smigel MD, Northup JK, Gilman AG. Characteristics of the guanine nucleotide-binding regulatory component of adenylate cyclase Recent Progress in Hormone Research. 38: 601-624. PMID 6289396 DOI: 10.1016/B978-0-12-571138-8.50019-6  0.639
1982 Schleifer LS, Kahn RA, Hanski E, Northup JK, Sternweis PC, Gilman AG. Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase Journal of Biological Chemistry. 257: 20-23. PMID 6273425  0.717
1981 Gilman AG, Sternweis PC, Northup JK. Purification and properties of the regulatory component of adenylate cyclase Biochemical Society Transactions. 9: 58P. DOI: 10.1042/Bst009058P  0.702
1981 Sternweis P, Northup J, Smigel M, Gilman A. The regulatory component of adenylate cyclase. Purification and properties. Journal of Biological Chemistry. 256: 11517-11526. DOI: 10.1016/s0021-9258(19)68431-0  0.639
1981 Hanski E, Sternweis P, Northup J, Dromerick A, Gilman A. The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein. Journal of Biological Chemistry. 256: 12911-12919. DOI: 10.1016/s0021-9258(18)42983-3  0.73
1980 Northup JK, Sternweis PC, Smigel MD, Schleifer LS, Ross EM, Gilman AG. Purification of the regulatory component of adenylate cyclase. Proceedings of the National Academy of Sciences of the United States of America. 77: 6516-20. PMID 6935665 DOI: 10.1073/Pnas.77.11.6516  0.712
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