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Taisuke Tomita - Publications

Affiliations: 
The University of Tokyo 
Area:
Alzheimer's disease
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184 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Futai E, Kawasaki H, Sato S, Daoudi K, Hidaka M, Tomita T, Ogawa T. A Metalloproteinase Cocktail from the Venom of Cleaves Amyloid Beta Peptides at the α-Cleavage Site. Toxins. 15. PMID 37624257 DOI: 10.3390/toxins15080500  0.318
2023 Tomizawa I, Chiu YW, Hori Y, Tomita T. [Identification of novel regulators involved in AD pathogenesis using the CRISPR-Cas9 system]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 158: 21-25. PMID 36596482 DOI: 10.1254/fpj.22081  0.303
2022 Kaneshiro N, Komai M, Imaoka R, Ikeda A, Kamikubo Y, Saito T, Saido TC, Tomita T, Hashimoto T, Iwatsubo T, Sakurai T, Uehara T, Takasugi N. Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's disease. Iscience. 25: 103869. PMID 35243232 DOI: 10.1016/j.isci.2022.103869  0.674
2022 Islam S, Sun Y, Gao Y, Nakamura T, Noorani AA, Li T, Wong PC, Kimura N, Matsubara E, Kasuga K, Ikeuchi T, Tomita T, Zou K, Michikawa M. Presenilin is essential for ApoE secretion, a novel role of presenilin involved in Alzheimer's disease pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34987110 DOI: 10.1523/JNEUROSCI.2039-21.2021  0.328
2021 Cai T, Tomita T. Sequential conformational changes in transmembrane domains of presenilin 1 in Aβ42 downregulation. Journal of Biochemistry. PMID 33739423 DOI: 10.1093/jb/mvab033  0.351
2020 Chiu YW, Hori Y, Ebinuma I, Sato H, Hara N, Ikeuchi T, Tomita T. Identification of calcium and integrin-binding protein 1 as a novel regulator of production of amyloid β peptide using CRISPR/Cas9-based screening system. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32307772 DOI: 10.1096/fj.201902966RR  0.423
2020 Cai T, Tomita T. Structure-activity relationship of presenilin in γ-secretase-mediated intramembrane cleavage. Seminars in Cell & Developmental Biology. PMID 32171519 DOI: 10.1016/j.semcdb.2020.02.006  0.439
2019 Cai T, Hatano A, Kanatsu K, Tomita T. Histidine 131 in presenilin 1 is the pH-sensitive residue that causes the increase in Aβ42 level in acidic pH. Journal of Biochemistry. PMID 31816046 DOI: 10.1093/jb/mvz110  0.402
2019 Cai T, Morishima K, Takagi-Niidome S, Tominaga A, Tomita T. Conformational dynamics of transmembrane domain 3 of presenilin 1 is associated with the trimming activity of γ-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31527118 DOI: 10.1523/JNEUROSCI.0838-19.2019  0.438
2019 Furusawa K, Takasugi T, Chiu YW, Hori Y, Tomita T, Fukuda M, Hisanaga SI. CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway. The Journal of Biological Chemistry. PMID 31138646 DOI: 10.1074/jbc.RA118.005385  0.43
2019 Suzuki T, Hori Y, Sawazaki T, Shimizu Y, Nemoto Y, Taniguchi A, Ozawa S, Sohma Y, Kanai M, Tomita T. Photo-oxygenation inhibits tau amyloid formation. Chemical Communications (Cambridge, England). PMID 31049495 DOI: 10.1039/c9cc01728c  0.381
2019 Brummer T, Müller SA, Pan-Montojo F, Yoshida F, Fellgiebel A, Tomita T, Endres K, Lichtenthaler SF. NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease. Embo Molecular Medicine. PMID 30833305 DOI: 10.15252/emmm.201809695  0.418
2019 Takatori S, Wang W, Iguchi A, Tomita T. Genetic Risk Factors for Alzheimer Disease: Emerging Roles of Microglia in Disease Pathomechanisms. Advances in Experimental Medicine and Biology. 1118: 83-116. PMID 30747419 DOI: 10.1007/978-3-030-05542-4_5  0.38
2019 Tomita T, Ozawa S, Sohma Y, Kanai M, Hori Y. P2-059: PHOTOOXYGENATION BY BIOCOMPATIBLE CATALYST REDUCES THE Aβ LEVEL IN THE BRAINS OF ALZHEIMER DISEASE MODEL MICE Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.2466  0.307
2018 Imai S, Cai T, Yoshida C, Tomita T, Futai E. Specific mutations in presenilin 1 cause conformational changes in γ-secretase to modulate amyloid beta trimming. Journal of Biochemistry. PMID 30289529 DOI: 10.1093/jb/mvy081  0.434
2018 Kanatsu K, Hori Y, Ebinuma I, Chiu YW, Tomita T. Retrograde transport of γ-secretase from endosomes to the trans-Golgi network regulates Aβ42 production. Journal of Neurochemistry. PMID 29851073 DOI: 10.1111/jnc.14477  0.425
2018 Takatori S, Tomita T. AP180 N-Terminal Homology (ANTH) and Epsin N-Terminal Homology (ENTH) Domains: Physiological Functions and Involvement in Disease. Advances in Experimental Medicine and Biology. PMID 29774507 DOI: 10.1007/5584_2018_218  0.376
2018 Nakamura A, Kaneko N, Villemagne VL, Kato T, Doecke J, Doré V, Fowler C, Li QX, Martins R, Rowe C, Tomita T, Matsuzaki K, Ishii K, Ishii K, Arahata Y, et al. High performance plasma amyloid-β biomarkers for Alzheimer's disease. Nature. 554: 249-254. PMID 29420472 DOI: 10.1038/Nature25456  0.325
2018 Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T. Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice. Embo Molecular Medicine. PMID 29311134 DOI: 10.15252/emmm.201708184  0.534
2018 Kaneko N, Matsuzaki M, Yoshizawa Y, Iwamoto S, Tanaka K, Tomita T. P1-200: ANALYSIS OF THE AMYLOID β-RELATED PEPTIDES IN MOUSE PLASMA AND CELL CULTURE MEDIA Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.204  0.301
2018 Ni J, Taniguchi A, Ozawa S, Hori Y, Kuninobu Y, Saito T, Saido TC, Tomita T, Sohma Y, Kanai M. Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide Chem. 4: 807-820. DOI: 10.1016/J.Chempr.2018.02.008  0.386
2017 Cai T, Yonaga M, Tomita T. Activation of γ-secretase trimming activity by topological changes of transmembrane domain 1 of presenilin 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29118109 DOI: 10.1523/JNEUROSCI.1628-17.2017  0.449
2017 Ito K, Makino M, Okado K, Tomita T. Memantine inhibits β-amyloid aggregation and disassembles preformed β-amyloid aggregates. Biochemical and Biophysical Research Communications. PMID 28917837 DOI: 10.1016/j.bbrc.2017.09.058  0.378
2017 Liu CY, Ohki Y, Tomita T, Osawa S, Reed BR, Jagust W, Berlo VV, Jin LW, Chui HC, Coppola G, Ringman JM. Two Novel Mutations in the First Transmembrane Domain of Presenilin1 Cause Young-Onset Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 28550247 DOI: 10.3233/JAD-161203  0.413
2017 Kikuchi K, Kidana K, Tatebe T, Tomita T. Dysregulated metabolism of the amyloid-β protein and therapeutic approaches in Alzheimer disease. Journal of Cellular Biochemistry. PMID 28488760 DOI: 10.1002/jcb.26129  0.388
2017 Sakurai S, Tomita T, Shimizu T, Ohto U. The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif. Acta Crystallographica. Section F, Structural Biology Communications. 73: 130-137. PMID 28291748 DOI: 10.1107/S2053230X17001911  0.34
2017 Ito K, Tatebe T, Suzuki K, Hirayama T, Hayakawa M, Kubo H, Tomita T, Makino M. Memantine reduces the production of amyloid-β peptides through modulation of amyloid precursor protein trafficking. European Journal of Pharmacology. PMID 28167259 DOI: 10.1016/j.ejphar.2017.02.001  0.402
2017 Tomita T. Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease. Advances in Biological Regulation. PMID 28082052 DOI: 10.1016/j.jbior.2017.01.001  0.4
2017 Tomita T. Probing the Structure and Function Relationships of Presenilin by Substituted-Cysteine Accessibility Method Methods in Enzymology. 584: 185-205. PMID 28065263 DOI: 10.1016/Bs.Mie.2016.10.033  0.386
2017 Tomita T, Ebinuma I, Tsuruya N, Hori Y. Genomewide Screening Of Molecules Involved In Uptake Of Alzheimer Disease-Associated Proteins By Cripsr/Cas9 System Alzheimers & Dementia. 13: 996. DOI: 10.1016/J.Jalz.2017.06.1374  0.311
2016 Kanatsu K, Hori Y, Takatori S, Watanabe T, Iwatsubo T, Tomita T. Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo. Human Molecular Genetics. PMID 27466196 DOI: 10.1093/hmg/ddw239  0.564
2016 Shinoda T, Shinya N, Ito K, Ishizuka-Katsura Y, Ohsawa N, Terada T, Hirata K, Kawano Y, Yamamoto M, Tomita T, Ishibashi Y, Hirabayashi Y, Kimura-Someya T, Shirouzu M, Yokoyama S. Cell-free methods to produce structurally intact mammalian membrane proteins. Scientific Reports. 6: 30442. PMID 27465719 DOI: 10.1038/srep30442  0.301
2016 Kanatsu K, Tomita T. Membrane trafficking and proteolytic activity of γ-secretase in Alzheimer disease. Biological Chemistry. PMID 27390881 DOI: 10.1515/hsz-2016-0146  0.414
2016 Reinhardt S, Grimm MO, Stahlmann C, Hartmann T, Shudo K, Tomita T, Endres K. Rescue of Hypovitaminosis A induces non-amyloidogenic Amyloid Precursor Protein (APP) Processing. Current Alzheimer Research. PMID 27335034 DOI: 10.2174/1567205013666160603002105  0.378
2016 Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Chang MY, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S, Iwatsubo T, Prendergast GC, Tomita T. BIN1 regulates BACE1 intracellular trafficking and amyloid-β production. Human Molecular Genetics. PMID 27179792 DOI: 10.1093/Hmg/Ddw146  0.572
2016 Hayashi Y, Nishimune H, Hozumi K, Saga Y, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T. A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons. Scientific Reports. 6: 23969. PMID 27040987 DOI: 10.1038/Srep23969  0.637
2016 Ueda N, Tomita T, Yanagisawa K, Kimura N. Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance. Journal of Neurochemistry. PMID 26896628 DOI: 10.1111/jnc.13586  0.432
2016 Tominaga A, Cai T, Takagi-Niidome S, Iwatsubo T, Tomita T. Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 1362-72. PMID 26818522 DOI: 10.1523/JNEUROSCI.5090-14.2016  0.577
2016 Ito K, Tatebe T, Suzuki K, Tomita T, Makino M. P4-072: The Inhibitory Effect of Memantine on the Production of Abeta Peptides Alzheimer's & Dementia. 12: P1041-P1041. DOI: 10.1016/j.jalz.2016.06.2162  0.337
2016 Kanatsu K, Hori Y, Takatori S, Tomita T. Partial Loss Of Picalm Predominantly Affects The Amyloid-Beta Deposition In The Piriform Cortex Of Mouse Model Of Alzheimer Disease Alzheimers & Dementia. 12: 1030. DOI: 10.1016/J.Jalz.2016.06.2130  0.36
2015 Futai E, Osawa S, Cai T, Fujisawa T, Ishiura S, Tomita T. Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities. The Journal of Biological Chemistry. PMID 26559975 DOI: 10.1074/jbc.M114.629287  0.391
2015 Takagi-Niidome S, Sasaki T, Osawa S, Sato T, Morishima K, Cai T, Iwatsubo T, Tomita T. Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2646-56. PMID 25673856 DOI: 10.1523/JNEUROSCI.3164-14.2015  0.538
2015 Takasugi N, Sasaki T, Shinohara M, Iwatsubo T, Tomita T. Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity. Biochemical and Biophysical Research Communications. 457: 194-9. PMID 25545059 DOI: 10.1016/j.bbrc.2014.12.087  0.567
2015 Tomita T, Kidana K, Tatebe T, Ouchi Y, Akishita M, Iwatsubo T. Pathophysiological impact of astrocyte-derived kallikrein-related peptidase 7 on Aβ metabolism in brain Alzheimers & Dementia. 11. DOI: 10.1016/J.Jalz.2015.06.594  0.446
2014 Tomita T. Molecular mechanism of intramembrane proteolysis by γ-secretase. Journal of Biochemistry. 156: 195-201. PMID 25108625 DOI: 10.1093/jb/mvu049  0.41
2014 Takeo K, Tanimura S, Shinoda T, Osawa S, Zahariev IK, Takegami N, Ishizuka-Katsura Y, Shinya N, Takagi-Niidome S, Tominaga A, Ohsawa N, Kimura-Someya T, Shirouzu M, Yokoshima S, Yokoyama S, ... ... Tomita T, et al. Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator. Proceedings of the National Academy of Sciences of the United States of America. 111: 10544-9. PMID 25009180 DOI: 10.1073/Pnas.1402171111  0.538
2014 Yonezawa H, Nishiyama Y, Takeo K, Iwatsubo T, Tomita T, Yokoshima S, Fukuyama T. New photocleavable linker: α-thioacetophenone-type linker. Bioorganic & Medicinal Chemistry Letters. 24: 2831-3. PMID 24841630 DOI: 10.1016/J.Bmcl.2014.04.104  0.456
2014 Kanatsu K, Morohashi Y, Suzuki M, Kuroda H, Watanabe T, Tomita T, Iwatsubo T. Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase. Nature Communications. 5: 3386. PMID 24577224 DOI: 10.1038/ncomms4386  0.567
2014 Ohki Y, Shimada N, Tominaga A, Osawa S, Higo T, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation. Molecular Neurodegeneration. 9: 7. PMID 24410857 DOI: 10.1186/1750-1326-9-7  0.57
2014 Taniguchi A, Sasaki D, Shiohara A, Iwatsubo T, Tomita T, Sohma Y, Kanai M. Attenuation of the aggregation and neurotoxicity of amyloid-β peptides by catalytic photooxygenation. Angewandte Chemie (International Ed. in English). 53: 1382-5. PMID 24339209 DOI: 10.1002/anie.201308001  0.516
2014 Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, et al. Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure (London, England : 1993). 22: 125-35. PMID 24210759 DOI: 10.1016/J.Str.2013.09.018  0.512
2014 Miyagawa T, Morohashi Y, Ojima R, Tsuji S, Iwatsubo T, Tomita T. Bin1 Regulates Bace1 Trafficking And Ab Production Alzheimers & Dementia. 10. DOI: 10.1016/J.Jalz.2014.05.314  0.437
2014 Tomita T, Tominaga A, Takagi-Niidome S, Iwatsubo T. Conformational Changes In The Transmembrane Domains 4 And 5 Of Presenilin 1 Associated With Altered Abeta42 Production Alzheimers & Dementia. 10. DOI: 10.1016/J.Jalz.2014.05.1113  0.508
2013 Iwatsubo T, Hashimoto T, Wakabayashi T, Tomita T, Morohashi Y. [Alzheimer disease: experimental approaches to genetic and environmental risk factors]. Rinshō Shinkeigaku = Clinical Neurology. 53: 956. PMID 24291845 DOI: DN/JST.JSTAGE/clinicalneurol/53.956  0.6
2013 Hoshi M, Ohki Y, Ito K, Tomita T, Iwatsubo T, Ishimaru Y, Abe K, Asakura T. Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana. Bmc Biochemistry. 14: 16. PMID 23829174 DOI: 10.1186/1471-2091-14-16  0.518
2013 Morohashi Y, Tomita T. Protein trafficking and maturation regulate intramembrane proteolysis. Biochimica Et Biophysica Acta. 1828: 2855-61. PMID 23770323 DOI: 10.1016/j.bbamem.2013.06.001  0.323
2013 Toyn JH, Rowley A, Matsuoka Y, Tomita T, Imbimbo BP. γ -Secretase Pharmacology: What Pharmacology Will Work for Alzheimer's Disease? International Journal of Alzheimer's Disease. 2013: 849128. PMID 23710414 DOI: 10.1155/2013/849128  0.39
2013 Takasugi N, Sasaki T, Ebinuma I, Osawa S, Isshiki H, Takeo K, Tomita T, Iwatsubo T. FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons. Plos One. 8: e64050. PMID 23667698 DOI: 10.1371/journal.pone.0064050  0.552
2013 Tomita T, Iwatsubo T. Structural biology of presenilins and signal peptide peptidases. The Journal of Biological Chemistry. 288: 14673-80. PMID 23585568 DOI: 10.1074/jbc.R113.463281  0.535
2013 Imamura Y, Umezawa N, Osawa S, Shimada N, Higo T, Yokoshima S, Fukuyama T, Iwatsubo T, Kato N, Tomita T, Higuchi T. Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition. Journal of Medicinal Chemistry. 56: 1443-54. PMID 23342950 DOI: 10.1021/Jm301306C  0.536
2013 Takagi-Niidome S, Osawa S, Tomita T, Iwatsubo T. Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1. Biochemistry. 52: 61-9. PMID 23210549 DOI: 10.1021/bi301252r  0.548
2013 Takasugi N, Sasaki T, Tomita T, Iwatsubo T. FTY720/Fingolimod, a sphingosine analogue, reduces beta-amyloid production in neurons Alzheimers & Dementia. 9: 184. DOI: 10.1016/J.Jalz.2013.05.311  0.556
2013 Tomita T, Suzuki K, Shiohara A, Osawa S, Iwatsubo T. Pathophysiological role of proteolytic cleavage of neuroligins Alzheimers & Dementia. 9: 144. DOI: 10.1016/J.Jalz.2013.04.097  0.446
2012 Tomita T. [Development of Alzheimer's disease treatment based on the molecular mechanism of γ-secretase activity]. Rinshō Shinkeigaku = Clinical Neurology. 52: 1165-7. PMID 23196551 DOI: DN/JST.JSTAGE/clinicalneurol/52.1165  0.419
2012 Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, ... ... Tomita T, et al. Activity-dependent proteolytic cleavage of neuroligin-1. Neuron. 76: 410-22. PMID 23083742 DOI: 10.1016/J.Neuron.2012.10.003  0.481
2012 Takeo K, Watanabe N, Tomita T, Iwatsubo T. Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein. The Journal of Biological Chemistry. 287: 25834-43. PMID 22689582 DOI: 10.1074/jbc.M111.336347  0.551
2012 Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, et al. Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin. Oncogene. 31: 787-98. PMID 21725355 DOI: 10.1038/Onc.2011.265  0.518
2012 Tomita T, Morohashi Y, Kanatsu K, Iwatsubo T. PICALM regulates Aβ42 production by modulation of gamma-secretase trafficking Alzheimers & Dementia. 8: 312. DOI: 10.1016/J.Jalz.2012.05.857  0.516
2011 Yonemura Y, Futai E, Yagishita S, Suo S, Tomita T, Iwatsubo T, Ishiura S. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system. The Journal of Biological Chemistry. 286: 44569-75. PMID 22074918 DOI: 10.1074/jbc.M111.270108  0.529
2011 Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1. The Embo Journal. 30: 4815-24. PMID 22002539 DOI: 10.1038/Emboj.2011.372  0.555
2011 Miyashita H, Maruyama Y, Isshiki H, Osawa S, Ogura T, Mio K, Sato C, Tomita T, Iwatsubo T. Three-dimensional structure of the signal peptide peptidase. The Journal of Biological Chemistry. 286: 26188-97. PMID 21636854 DOI: 10.1074/jbc.M111.260273  0.515
2011 Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, Shimada N, Higo T, Yokoshima S, Fukuyama T, Lee VM, Trojanowski JQ, Tomita T, Iwatsubo T. BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6850-7. PMID 21543615 DOI: 10.1016/J.Jalz.2011.05.1193  0.522
2011 Tomita T, Wong PC. Selectivity to amyloid-β precursor protein cleavage provides hope against Alzheimer's. Alzheimer's Research & Therapy. 3: 7. PMID 21418547 DOI: 10.1186/Alzrt66  0.421
2010 Takagi S, Tominaga A, Sato C, Tomita T, Iwatsubo T. Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15943-50. PMID 21106832 DOI: 10.1523/JNEUROSCI.3318-10.2010  0.696
2010 Morohashi Y, Tomita T, Iwatsubo T. [Molecular targeted therapy in Alzheimer disease]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 68: 1906-10. PMID 20954338  0.495
2010 Asai M, Iwata N, Tomita T, Iwatsubo T, Ishiura S, Saido TC, Maruyama K. Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease. Journal of Neuroscience Research. 88: 3588-97. PMID 20890992 DOI: 10.1002/jnr.22503  0.539
2010 Fukumoto H, Takahashi H, Tarui N, Matsui J, Tomita T, Hirode M, Sagayama M, Maeda R, Kawamoto M, Hirai K, Terauchi J, Sakura Y, Kakihana M, Kato K, Iwatsubo T, et al. A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11157-66. PMID 20720123 DOI: 10.1523/JNEUROSCI.2884-10.2010  0.557
2010 Kurosumi M, Nishio Y, Osawa S, Kobayashi H, Iwatsubo T, Tomita T, Miyachi H. Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library. Bioorganic & Medicinal Chemistry Letters. 20: 5282-5. PMID 20650635 DOI: 10.1016/j.bmcl.2010.06.131  0.464
2010 Watanabe N, Image Image II, Takagi S, Image Image II, Tominaga A, Image Image I, Tomita T, Image Image II, Iwatsubo T, Image Image I. Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase. The Journal of Biological Chemistry. 285: 19738-46. PMID 20418378 DOI: 10.1074/jbc.M110.101287  0.581
2010 Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T. Corrigendum to "Development of photoaffinity probes for γ-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker" [Bioorg. Med. Chem. Lett. 19 (2009) 6869] (DOI:10.1016/j.bmcl.2009.10.086) Bioorganic and Medicinal Chemistry Letters. 20: 1798-1799. DOI: 10.1016/J.Bmcl.2010.01.025  0.391
2009 Tomita T. [Alzheimer's disease treatment by inhibition/modulation of the gamma-secretase activity]. Rinshō Shinkeigaku = Clinical Neurology. 49: 845-7. PMID 20030227 DOI: 10.5692/clinicalneurol.49.845  0.456
2009 Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T. Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker. Bioorganic & Medicinal Chemistry Letters. 19: 6869-71. PMID 19892551 DOI: 10.1016/J.Bmcl.2009.10.086  0.474
2009 Masuda S, Kumano K, Suzuki T, Tomita T, Iwatsubo T, Natsugari H, Tojo A, Shibutani M, Mitsumori K, Hanazono Y, Ogawa S, Kurokawa M, Chiba S. Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model. Cancer Science. 100: 2444-50. PMID 19775286 DOI: 10.1111/j.1349-7006.2009.01328.x  0.445
2009 Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T. Single chain variable fragment against nicastrin inhibits the gamma-secretase activity. The Journal of Biological Chemistry. 284: 27838-47. PMID 19684016 DOI: 10.1074/Jbc.M109.055061  0.575
2009 Imamura Y, Watanabe N, Umezawa N, Iwatsubo T, Kato N, Tomita T, Higuchi T. Inhibition of gamma-secretase activity by helical beta-peptide foldamers. Journal of the American Chemical Society. 131: 7353-9. PMID 19432477 DOI: 10.1021/ja9001458  0.571
2009 Tomita T. Secretase inhibitors and modulators for Alzheimer's disease treatment. Expert Review of Neurotherapeutics. 9: 661-79. PMID 19402777 DOI: 10.1586/ern.09.24  0.443
2009 Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, et al. S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. The Journal of Biological Chemistry. 284: 1373-84. PMID 19028695 DOI: 10.1074/Jbc.M806380200  0.587
2009 Tomita T, Hayashi I, Takatori S, Urano Y, Iwanari H, Kodama T, Hamakubo T, Iwatsubo T. Single chain variable fragment against nicastrin inhibits the γ-secretase activity Alzheimers & Dementia. 5. DOI: 10.1016/J.Jalz.2009.05.225  0.459
2009 Takatori S, Hayashi I, Urano Y, Kodama T, Hamakubo T, Tomita T, Iwatsubo T. Intrabody against immature nicastrin disrupts the proper folding and the glycosyl maturation of the extracellular domain of nicastrin Alzheimers & Dementia. 5: 317. DOI: 10.1016/J.Jalz.2009.04.504  0.477
2009 Miyashita H, Maruyama Y, Ogura T, Mio K, Iwatsubo T, Tomita T, Sato C. Three dimensional structure of signal peptide peptidase Alzheimers & Dementia. 5: 317. DOI: 10.1016/J.Jalz.2009.04.503  0.452
2008 Tomita T. [Targeting the structure and function relationships of the gamma-secretase for the development of Alzheimer's disease]. Rinshō Shinkeigaku = Clinical Neurology. 48: 907-9. PMID 19198114 DOI: 10.5692/Clinicalneurol.48.907  0.49
2008 Laras Y, Pietrancosta N, Tomita T, Iwatsubo T, Kraus JL. Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Abeta-peptide production inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 23: 996-1001. PMID 18608784 DOI: 10.1080/14756360701832706  0.528
2008 Cheung KH, Shineman D, Müller M, Cárdenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM, Foskett JK. Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron. 58: 871-83. PMID 18579078 DOI: 10.1016/J.Neuron.2008.04.015  0.487
2008 Sato C, Takagi S, Tomita T, Iwatsubo T. The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6264-71. PMID 18550769 DOI: 10.1523/JNEUROSCI.1163-08.2008  0.692
2008 Kumano K, Masuda S, Sata M, Saito T, Lee SY, Sakata-Yanagimoto M, Tomita T, Iwatsubo T, Natsugari H, Kurokawa M, Ogawa S, Chiba S. Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis. Pigment Cell & Melanoma Research. 21: 70-8. PMID 18353145 DOI: 10.1111/j.1755-148X.2007.00423.x  0.453
2008 Tomita T. At the frontline of Alzheimer's disease treatment: gamma-secretase inhibitor/modulator mechanism. Naunyn-Schmiedeberg's Archives of Pharmacology. 377: 295-300. PMID 18038124 DOI: 10.1007/s00210-007-0206-2  0.478
2008 Tomita T. Peptides inhibiting specific cleaving activities of presenilins Expert Opinion On Therapeutic Patents. 18: 1097-1100. DOI: 10.1517/13543776.18.9.1097  0.413
2008 Tomita T, Sato C, Takagi S, Iwatsubo T. O4-03-03: C-terminal PAL motif of presenilin 1 comprises the subsite of gamma-secretase within the catalytic pore Alzheimer's & Dementia. 4: T189-T189. DOI: 10.1016/j.jalz.2008.05.520  0.627
2008 Watanabe N, Tomita T, Iwatsubo T. P4-211: The functional roles of transmembrane domains of presenilin 1 in the formation of active gamma-secretase complex Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.2279  0.525
2008 Takagi S, Sato C, Tomita T, Iwatsubo T. P4-208: Transmembrane domain 1 of presenilin 1 contributes to the formation of the catalytic pore of gamma-secretase Alzheimer's & Dementia. 4: T732-T732. DOI: 10.1016/j.jalz.2008.05.2276  0.65
2008 Sugimoto Y, Fuwa H, Yokoshima S, Fukuyama T, Sasaki M, Tomita T, Iwatsubo T. P4-207: Chemical biological analysis of gamma-secretase using arylsulfonamide-type inhibitors Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.2275  0.467
2008 Takasugi N, Suzuki K, Isshiki H, Tomita T, Iwatsubo T. P3-348: Neuron-specific regulation of beta-secretase activity by sphingosine kinase Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1917  0.469
2007 Fuwa H, Takahashi Y, Konno Y, Watanabe N, Miyashita H, Sasaki M, Natsugari H, Kan T, Fukuyama T, Tomita T, Iwatsubo T. Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors. Acs Chemical Biology. 2: 408-18. PMID 17530731 DOI: 10.1021/Cb700073Y  0.512
2007 Kan T, Kita Y, Morohashi Y, Tominari Y, Hosoda S, Tomita T, Natsugari H, Iwatsubo T, Fukuyama T. Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities. Organic Letters. 9: 2055-8. PMID 17480083 DOI: 10.1021/Ol070376I  0.468
2007 Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, Tsuji S, Tomita T, Iwatsubo T. Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate. The Journal of Biological Chemistry. 282: 12388-96. PMID 17329245 DOI: 10.1074/jbc.M611549200  0.711
2007 Kan T, Kita Y, Morohashi Y, Tominari Y, Hosoda S, Tomita T, Natsugari H, Iwatsubo T, Fukuyama T. Photoaffinity Probes for Alzheimer’s Disease Synfacts. 2007: 995-995. DOI: 10.1055/S-2007-968915  0.359
2007 Hayashi Y, Tomita T, Kopan R, Iwatsubo T. The role of Notch signaling in synaptogenesis Neuroscience Research. 58. DOI: 10.1016/J.Neures.2007.06.863  0.591
2006 Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron. 52: 831-43. PMID 17145504 DOI: 10.1016/J.Neuron.2006.10.035  0.647
2006 Sato C, Morohashi Y, Tomita T, Iwatsubo T. Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12081-8. PMID 17108181 DOI: 10.1523/JNEUROSCI.3614-06.2006  0.689
2006 Ozaki T, Li Y, Kikuchi H, Tomita T, Iwatsubo T, Nakagawara A. The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis. Biochemical and Biophysical Research Communications. 351: 57-63. PMID 17054906 DOI: 10.1016/j.bbrc.2006.09.162  0.512
2006 Tomita T, Tanaka S, Morohashi Y, Iwatsubo T. Presenilin-dependent intramembrane cleavage of ephrin-B1. Molecular Neurodegeneration. 1: 2. PMID 16930449 DOI: 10.1186/1750-1326-1-2  0.575
2006 Garino C, Tomita T, Pietrancosta N, Laras Y, Rosas R, Herbette G, Maigret B, Quéléver G, Iwatsubo T, Kraus JL. Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays. Journal of Medicinal Chemistry. 49: 4275-85. PMID 16821787 DOI: 10.1021/jm0602864  0.514
2006 Fuwa H, Hiromoto K, Takahashi Y, Yokoshima S, Kan T, Fukuyama T, Iwatsubo T, Tomita T, Natsugari H. Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 4184-9. PMID 16766183 DOI: 10.1016/J.Bmcl.2006.05.091  0.466
2006 Takahashi Y, Fuwa H, Kaneko A, Sasaki M, Yokoshima S, Koizumi H, Takebe T, Kan T, Iwatsubo T, Tomita T, Natsugari H, Fukuyama T. Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorganic & Medicinal Chemistry Letters. 16: 3813-6. PMID 16682195 DOI: 10.1016/J.Bmcl.2006.04.025  0.461
2006 Keller PC, Tomita T, Hayashi I, Chandu D, Weber JD, Cistola DP, Kopan R. A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substrates. Biochemistry. 45: 5351-8. PMID 16618124 DOI: 10.1021/Bi052228A  0.769
2006 Morohashi Y, Kan T, Tominari Y, Fuwa H, Okamura Y, Watanabe N, Sato C, Natsugari H, Fukuyama T, Iwatsubo T, Tomita T. C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester). The Journal of Biological Chemistry. 281: 14670-6. PMID 16569643 DOI: 10.1074/Jbc.M513012200  0.682
2006 Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Iwastubo T, Tomita T, Sato C. Three-dimensional structure of the gamma-secretase complex. Biochemical and Biophysical Research Communications. 343: 525-34. PMID 16546128 DOI: 10.1016/j.bbrc.2006.02.158  0.687
2006 Yang X, Tomita T, Wines-Samuelson M, Beglopoulos V, Tansey MG, Kopan R, Shen J. Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord. Developmental Neuroscience. 28: 102-17. PMID 16508308 DOI: 10.1159/000090757  0.519
2006 Tomita T, Iwatsubo T. gamma-secretase as a therapeutic target for treatment of Alzheimer's disease. Current Pharmaceutical Design. 12: 661-70. PMID 16472155 DOI: 10.2174/138161206775474206  0.592
2006 Tomita T, Takahashi Y, Fuwa H, Konno Y, Morohashi Y, Kan T, Sugimoto Y, Fukuyama T, Sasaki M, Natsugari H, Iwatsubo T. O1-02-07 Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.259  0.483
2006 Sato C, Watanabe N, Morohashi Y, Tomita T, Iwatsubo T. P3-416: Probing the structural changes of presenilin 1 by substituted-cysteine accessibility method Alzheimer's & Dementia. 2: S498-S498. DOI: 10.1016/j.jalz.2006.05.1687  0.594
2006 Hayashi I, Urano Y, Iwanari H, Kodama T, Hamakubo T, Tomita T, Iwatsubo T. P3-412: Generation of monoclonal antibodies against the extracellular domain of nicastrin Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1683  0.429
2006 Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Tomita T, Sato C. Corrigendum to "Three-dimensional structure of the γ-secretase complex" [Biochem. Biophys. Res. Commun. 343 (2006) 525-534] (DOI:10.1016/j.bbrc.2006.02.158) Biochemical and Biophysical Research Communications. 345: 543. DOI: 10.1016/j.bbrc.2006.04.025  0.607
2006 Fuwa H, Kaneko A, Sugimoto Y, Tomita T, Iwatsubo T, Sasaki M. Concise and short synthesis of functionalized 5,6-dihydropyridin-2-ones by means of palladium(0)-catalyzed cross-coupling of ketene aminal phosphates Heterocycles. 70: 101-106. DOI: 10.1002/CHIN.200722128  0.411
2005 Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T. Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1. The Journal of Biological Chemistry. 280: 41967-75. PMID 16234244 DOI: 10.1074/jbc.M509066200  0.685
2005 Takeda T, Asahi M, Yamaguchi O, Hikoso S, Nakayama H, Kusakari Y, Kawai M, Hongo K, Higuchi Y, Kashiwase K, Watanabe T, Taniike M, Nakai A, Nishida K, Kurihara S, ... ... Tomita T, et al. Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 2069-71. PMID 16204356 DOI: 10.1096/Fj.05-3744Fje  0.453
2005 Urano Y, Hayashi I, Isoo N, Reid PC, Shibasaki Y, Noguchi N, Tomita T, Iwatsubo T, Hamakubo T, Kodama T. Association of active gamma-secretase complex with lipid rafts. Journal of Lipid Research. 46: 904-12. PMID 15716592 DOI: 10.1194/jlr.M400333-JLR200  0.571
2005 Niimura M, Isoo N, Takasugi N, Tsuruoka M, Ui-Tei K, Saigo K, Morohashi Y, Tomita T, Iwatsubo T. Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions. The Journal of Biological Chemistry. 280: 12967-75. PMID 15644323 DOI: 10.1074/jbc.M409829200  0.563
2004 Tomita T, Iwatsubo T. [Recent advances in Alzheimer's disease-related gamma-secretase complex]. Seikagaku. the Journal of Japanese Biochemical Society. 76: 666-70. PMID 15346905  0.449
2004 Tomita T, Iwatsubo T. The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease. Drug News & Perspectives. 17: 321-5. PMID 15334182 DOI: 10.1358/dnp.2004.17.5.829036  0.579
2004 Hayashi I, Urano Y, Fukuda R, Isoo N, Kodama T, Hamakubo T, Tomita T, Iwatsubo T. Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles. The Journal of Biological Chemistry. 279: 38040-6. PMID 15215237 DOI: 10.1074/jbc.M405597200  0.552
2004 Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K. Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice. The European Journal of Neuroscience. 19: 2826-38. PMID 15147316 DOI: 10.1111/j.0953-816X.2004.03397.x  0.542
2004 Kan T, Tominari Y, Rikimaru K, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T. Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity. Bioorganic & Medicinal Chemistry Letters. 14: 1983-5. PMID 15050642 DOI: 10.1016/J.Bmcl.2004.01.067  0.435
2004 Matsubayashi H, Sese S, Lee JS, Shirakawa T, Iwatsubo T, Tomita T, Yanagawa S. Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference. Molecular and Cellular Biology. 24: 2012-24. PMID 14966281 DOI: 10.1128/MCB.24.5.2012-2024.2004  0.448
2004 Fukumoto H, Kosaka T, Sagayama M, Kawamoto M, Tomita T, Terauchi J, Tarui N, Kakihana M, Iwatsubo T, Miyamoto M. P4-376 TAK-070, a non-peptidic bace inhibitor inhibits secretion of amyloid beta 40/42 and enhances sappalpha production in neuronal cell cultures Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81934-1  0.517
2004 Morohashi Y, Tominari Y, Watanabe N, Kan T, Fuwa H, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T. P4-322 Presenilin-1 is a molecular target of a dipeptidic γ-secretase inhibitor, DAPT Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81880-3  0.457
2004 Tomita T, Niimura M, Hayashi I, Sato C, Tanaka S, Shinohara M, Takahashi Y, Morohashi Y, Iwatsubo T. O3-05-04 Roles of presenilin cofactors in the assembly and activity of {gamma}-secretase complex Neurobiology of Aging. 25: S62. DOI: 10.1016/S0197-4580(04)80209-4  0.63
2004 Fuwa H, Okamura Y, Morohashi Y, Tomita T, Iwatsubo T, Kan T, Fukuyama T, Natsugari H. Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of ω-azido pentafluorophenyl ester: Synthesis and biological evaluation of LY411575 analogues Tetrahedron Letters. 45: 2323-2326. DOI: 10.1016/J.Tetlet.2004.01.087  0.428
2003 Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, et al. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 13075-80. PMID 14566063 DOI: 10.1073/Pnas.1735338100  0.794
2003 Abe Y, Kouyama K, Tomita T, Tomita Y, Ban N, Nawa M, Matsuoka M, Niikura T, Aiso S, Kita Y, Iwatsubo T, Nishimoto I. Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8513-25. PMID 13679420 DOI: 10.1523/Jneurosci.23-24-08513.2003  0.504
2003 Kan T, Tominari Y, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T. Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups. Chemical Communications (Cambridge, England). 2244-5. PMID 13678222 DOI: 10.1039/B306970B  0.41
2003 Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R. APP processing and synaptic function. Neuron. 37: 925-37. PMID 12670422 DOI: 10.1016/S0896-6273(03)00124-7  0.533
2003 Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T. The role of presenilin cofactors in the gamma-secretase complex. Nature. 422: 438-41. PMID 12660785 DOI: 10.1038/Nature01506  0.586
2003 Takahashi Y, Hayashi I, Tominari Y, Rikimaru K, Morohashi Y, Kan T, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T. Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. The Journal of Biological Chemistry. 278: 18664-70. PMID 12637581 DOI: 10.1074/Jbc.M301619200  0.581
2003 Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De Strooper B, Yumoto E, Saya H. Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. Oncogene. 22: 1511-6. PMID 12629514 DOI: 10.1038/sj.onc.1206298  0.464
2002 Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiology of Disease. 11: 64-82. PMID 12460547 DOI: 10.1006/Nbdi.2002.0546  0.557
2002 Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T. The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals. The Journal of Biological Chemistry. 277: 50198-205. PMID 12388554 DOI: 10.1074/jbc.M205352200  0.575
2002 Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. The Embo Journal. 21: 5408-16. PMID 12374741 DOI: 10.1093/Emboj/Cdf541  0.607
2002 Tomita T, Katayama R, Takikawa R, Iwatsubo T. Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments. Febs Letters. 520: 117-21. PMID 12044882 DOI: 10.1016/S0014-5793(02)02802-8  0.525
2002 Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T. Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. The Journal of Biological Chemistry. 277: 14965-75. PMID 11847232 DOI: 10.1074/jbc.M200897200  0.53
2001 Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R, De Strooper B, Iwatsubo T. The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins. The Journal of Biological Chemistry. 276: 33273-81. PMID 11432849 DOI: 10.1074/jbc.M011152200  0.712
2001 Iwata H, Tomita T, Maruyama K, Iwatsubo T. Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2. The Journal of Biological Chemistry. 276: 21678-85. PMID 11283011 DOI: 10.1074/jbc.M007989200  0.566
2001 Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC. Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. The Journal of Biological Chemistry. 276: 21895-901. PMID 11278416 DOI: 10.1074/Jbc.M008511200  0.501
2001 Ohya S, Morohashi Y, Muraki K, Tomita T, Watanabe M, Iwatsubo T, Imaizumi Y. Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2. Biochemical and Biophysical Research Communications. 282: 96-102. PMID 11263977 DOI: 10.1006/bbrc.2001.4558  0.461
2000 Takahashi M, Doré S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR, Iwatsubo T, Kim SH, Thinakaran G, Sisodia SS, Snyder SH. Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease. Neuron. 28: 461-73. PMID 11144356 DOI: 10.1016/S0896-6273(00)00125-2  0.581
2000 Houlden H, Baker M, McGowan E, Lewis P, Hutton M, Crook R, Wood NW, Kumar-Singh S, Geddes J, Swash M, Scaravilli F, Holton JL, Lashley T, Tomita T, Hashimoto T, et al. Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations. Annals of Neurology. 48: 806-8. PMID 11079548 DOI: 10.1002/1531-8249(200011)48:5<806::Aid-Ana18>3.0.Co;2-F  0.382
2000 Saura CA, Tomita T, Soriano S, Takahashi M, Leem JY, Honda T, Koo EH, Iwatsubo T, Thinakaran G. The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants. The Journal of Biological Chemistry. 275: 17136-42. PMID 10748144 DOI: 10.1074/Jbc.M909624199  0.594
2000 Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC, Mori H, Ishiura S. Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain. International Journal of Molecular Medicine. 5: 269-73. PMID 10677567 DOI: 10.3892/Ijmm.5.3.269  0.49
2000 Leem JY, Saura C, Tomita T, Iwatsubo T, Thinakaran G. Structural domain requirements for presenilin endoproteolysis and Aβ42 overproduction Neurobiology of Aging. 21: 261. DOI: 10.1016/S0197-4580(00)83129-2  0.513
2000 Kamenetz F, Borchelt DR, Tomita T, Iwatsubo T, Sisodia S, Malinow R. Aβ as a homeostatic negative regulator of synaptic function? Neurobiology of Aging. 21: 76-77. DOI: 10.1016/S0197-4580(00)82567-1  0.459
2000 Iwatsubo T, Tomita T, Takikawa R, Watabiki T, Morohashi Y, Takasugi N. Structure-function analysis of presenilins Neurobiology of Aging. 21: 140. DOI: 10.1016/S0197-4580(00)82428-8  0.434
2000 Tomita T, Takasugi N, Takikawa R, Watabiki T, Yauchi M, Iwatsubo T. The integrity of carboxyl terminus of presenilin 2 is essential for its functions Neurobiology of Aging. 21: 110-111. DOI: 10.1016/S0197-4580(00)82295-2  0.438
1999 Tomita T, Iwatsubo T. [Molecular cell biology of presenilins]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 114: 337-46. PMID 10672594 DOI: 10.1254/Fpj.114.337  0.571
1999 Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T. C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10627-34. PMID 10594046  0.515
1999 Fukumoto H, Tomita T, Matsunaga H, Ishibashi Y, Saido TC, Iwatsubo T. Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid beta peptides ending at A beta40 and A beta42. Neuroreport. 10: 2965-9. PMID 10549806 DOI: 10.1097/00001756-199909290-00017  0.487
1999 Okamura N, Arai H, Higuchi M, Tashiro M, Matsui T, Itoh M, Iwatsubo T, Tomita T, Sasaki H. Cerebrospinal fluid levels of amyloid beta-peptide1-42, but not tau have positive correlation with brain glucose metabolism in humans. Neuroscience Letters. 273: 203-7. PMID 10515194 DOI: 10.1016/S0304-3940(99)00644-8  0.505
1999 Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, ... Tomita T, et al. A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. The Journal of Biological Chemistry. 274: 28669-73. PMID 10497236 DOI: 10.1074/Jbc.274.40.28669  0.718
1999 Murayama O, Tomita T, Nihonmatsu N, Murayama M, Sun X, Honda T, Iwatsubo T, Takashima A. Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease. Neuroscience Letters. 265: 61-3. PMID 10327206 DOI: 10.1016/S0304-3940(99)00187-1  0.57
1999 Saura CA, Tomita T, Davenport F, Harris CL, Iwatsubo T, Thinakaran G. Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing Journal of Biological Chemistry. 274: 13818-13823. PMID 10318786 DOI: 10.1074/Jbc.274.20.13818  0.559
1999 Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T. C Terminus of Presenilin Is Required for Overproduction of Amyloidogenic Aβ42 through Stabilization and Endoproteolysis of Presenilin The Journal of Neuroscience. 19: 10627-10634. DOI: 10.1523/Jneurosci.19-24-10627.1999  0.569
1999 Nishiyama K, Trapp BD, Ikezu T, Ransohoff RM, Tomita T, Iwatsubo T, Kanazawa I, Hsiao KK, Lisanti MP, Okamoto T. Caveolin-3 Upregulation Activates β-Secretase–Mediated Cleavage of the Amyloid Precursor Protein in Alzheimer’s Disease The Journal of Neuroscience. 19: 6538-6548. DOI: 10.1523/Jneurosci.19-15-06538.1999  0.559
1998 Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty DD, Price DL, Borchelt DR, Wong PC, Sisodia SS. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron. 21: 1213-21. PMID 9856475 DOI: 10.1016/S0896-6273(00)80637-6  0.513
1998 Shinozaki K, Maruyama K, Kume H, Tomita T, Saido TC, Iwatsubo T, Obata K. The presenilin 2 loop domain interacts with the mu-calpain C-terminal region. International Journal of Molecular Medicine. 1: 797-9. PMID 9852298 DOI: 10.3892/Ijmm.1.5.797  0.546
1998 Tu PH, Galvin JE, Baba M, Giasson B, Tomita T, Leight S, Nakajo S, Iwatsubo T, Trojanowski JQ, Lee VM. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Annals of Neurology. 44: 415-22. PMID 9749615 DOI: 10.1002/Ana.410440324  0.444
1998 Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido TC, Maruyama K, Iwatsubo T. Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42. The Journal of Biological Chemistry. 273: 21153-60. PMID 9694871 DOI: 10.1074/Jbc.273.33.21153  0.721
1998 Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, et al. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. Journal of Neurochemistry. 71: 313-22. PMID 9648880 DOI: 10.1046/J.1471-4159.1998.71010313.X  0.62
1998 Tomita T, Chang TY, Kodama T, Iwatsubo T. βAPP γ-secretase and SREBP site 2 protease are two different enzymes Neuroreport. 9: 911-913. PMID 9579689 DOI: 10.1097/00001756-199803300-00027  0.552
1998 Tokuhiro S, Tomita T, Iwata H, Kosaka T, Saido TC, Maruyama K, Iwatsubo T. The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells. Biochemical and Biophysical Research Communications. 244: 751-5. PMID 9535737 DOI: 10.1006/bbrc.1998.8336  0.486
1998 Iwatsubo T, Baba M, Nakaio S, Tu P-, Tomita T, Nakaya K, -Y. Lee VM, Trojanowski JQ. α-SYNUCLEIN IS A COMPONENT OF LEWY BODIES Journal of Neuropathology and Experimental Neurology. 57: 509. DOI: 10.1097/00005072-199805000-00179  0.312
1997 Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Grünberg J, Haass C, Iwatsubo T, Obata K. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue. Proceedings of the National Academy of Sciences of the United States of America. 94: 2025-30. PMID 9050898 DOI: 10.1073/Pnas.94.5.2025  0.552
1996 Maruyama K, Tomita T, Shinozaki K, Kume H, Asada H, Saido TC, Ishiura S, Iwatsubo T, Obata K. Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43). Biochemical and Biophysical Research Communications. 227: 730-5. PMID 8886002 DOI: 10.1006/bbrc.1996.1577  0.533
1996 Kume H, Maruyama K, Tomita T, Iwatsubo T, Saido TC, Obata K. Molecular cloning of a novel basic helix-loop-helix protein from the rat brain. Biochemical and Biophysical Research Communications. 219: 526-30. PMID 8605021 DOI: 10.1006/bbrc.1996.0267  0.478
1996 Maruyama K, Tomita T, Ishiura S, Kume H, Kuzume H, Asada H, Kawamura Y, Kanbara N, Saido TC, Iwatsubo T, Obata K. 399 The familial Alzheimer disease-linked mutations of Val717 of amyloid precursor protein is specific for the increased secretion of the longer Aβ Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80401-5  0.544
1996 Tomita T, Maruyama K, Saido T, Hosoda R, Tokuhiro S, Kume H, Kuzume H, Asada H, Kawamura Y, Iwatsubo T, Obata K. 59 Characterization of presenilins overexpressed in culture cells Neurobiology of Aging. 17: S15. DOI: 10.1016/S0197-4580(96)80061-3  0.423
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