Jaana A. Hartiala, Ph.D. - Publications

Affiliations: 
2014 Preventive Medicine (Health Behavior Research) University of Southern California, Los Angeles, CA, United States 
Area:
Genetics, Computer Science, Biostatistics Biology

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Schunk SJ, Kleber ME, März W, Pang S, Zewinger S, Triem S, Ege P, Reichert MC, Krawczyk M, Weber SN, Jaumann I, Schmit D, Sarakpi T, Wagenpfeil S, Kramann R, ... ... Hartiala JA, et al. Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality. European Heart Journal. PMID 33748830 DOI: 10.1093/eurheartj/ehab107  0.4
2021 Hilser JR, Han Y, Biswas S, Gukasyan J, Cai Z, Zhu R, Tang WHW, Deb A, Lusis AJ, Hartiala JA, Allayee H. Association of serum HDL cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection. Journal of Lipid Research. 100061. PMID 33667465 DOI: 10.1016/j.jlr.2021.100061  0.4
2021 Hartiala JA, Han Y, Jia Q, Hilser JR, Huang P, Gukasyan J, Schwartzman WS, Cai Z, Biswas S, Trégouët DA, Smith NL, Seldin M, et al. Genome-wide analysis identifies novel susceptibility loci for myocardial infarction. European Heart Journal. PMID 33532862 DOI: 10.1093/eurheartj/ehaa1040  0.4
2020 van Zuydam NR, Ladenvall C, Voight BF, Strawbridge RJ, Fernandez-Tajes J, Rayner NW, Robertson NR, Mahajan A, Vlachopoulou E, Goel A, Kleber ME, Nelson CP, Kwee LC, Esko T, Mihailov E, ... ... Hartiala JA, et al. Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus. Circulation. Genomic and Precision Medicine. 13: e002769. PMID 33321069 DOI: 10.1161/CIRCGEN.119.002769  0.4
2020 Mahmoodi BK, Tragante V, Kleber ME, Holmes MV, Schmidt AF, McCubrey RO, Howe LJ, Direk K, Allayee H, Baranova EV, Braund PS, Delgado GE, Eriksson N, Gijsberts CM, Gong Y, ... Hartiala J, et al. Association of Factor V Leiden with Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data. Circulation. PMID 32654539 DOI: 10.1161/Circulationaha.119.045526  0.4
2020 Han Y, Jia Q, Jahani PS, Hurrell BP, Pan C, Huang P, Gukasyan J, Woodward NC, Eskin E, Gilliland FD, Akbari O, Hartiala JA, Allayee H. Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma. Nature Communications. 11: 1776. PMID 32296059 DOI: 10.1038/S41467-020-15649-3  0.4
2019 Maazi H, Hartiala JA, Suzuki Y, Crow AL, Shafiei Jahani P, Lam J, Patel N, Rigas D, Han Y, Huang P, Eskin E, Lusis AJ, Gilliland FD, Akbari O, Allayee H. A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity. Plos Genetics. 15: e1008528. PMID 31869344 DOI: 10.1371/Journal.Pgen.1008528  0.4
2019 Jia Q, Han Y, Huang P, Woodward NC, Gukasyan J, Kettunen J, Ala-Korpela M, Anufrieva O, Wang Q, Perola M, Raitakari O, Lehtimäki T, Viikari J, Järvelin MR, Boehnke M, ... ... Hartiala JA, et al. Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease. Journal of the American Heart Association. 8: e011922. PMID 31070104 DOI: 10.1161/Jaha.119.011922  0.4
2019 Patel RS, Schmidt AF, Tragante V, McCubrey RO, Holmes MV, Howe LJ, Direk K, Åkerblom A, Leander K, Virani SS, Kaminski KA, Muehlschlegel JD, Dubé MP, Allayee H, Almgren P, ... ... Hartiala J, et al. Association of Chromosome 9p21 with Subsequent Coronary Heart Disease Events: A GENIUS-CHD Study of Individual Participant Data. Circulation. Genomic and Precision Medicine. PMID 30897348 DOI: 10.1161/CIRCGEN.119.002471  0.4
2019 Woodward NC, Crow AL, Zhang Y, Epstein S, Hartiala J, Johnson R, Kocalis H, Saffari A, Sankaranarayanan I, Akbari O, Ramanathan G, Araujo JA, Finch CE, Bouret SG, Sioutas C, et al. Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice. Scientific Reports. 9: 1816. PMID 30755631 DOI: 10.1038/S41598-018-37704-2  0.4
2018 Li XS, Wang Z, Cajka T, Buffa JA, Nemet I, Hurd AG, Gu X, Skye SM, Roberts AB, Wu Y, Li L, Shahen CJ, Wagner MA, Hartiala JA, Kerby RL, et al. Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk. Jci Insight. 3. PMID 29563342 DOI: 10.1172/Jci.Insight.99096  0.4
2018 Barrington WT, Salvador AC, Hartiala JA, De Caterina R, Kohlmeier M, Martinez JA, Kreutzer CB, Heber D, Lusis AJ, Li Z, Allayee H. Proceedings of the 11th Congress of the International Society of Nutrigenetics and Nutrigenomics (ISNN 2017). Journal of Nutrigenetics and Nutrigenomics. 10: 155-162. PMID 29339647 DOI: 10.1159/000485799  0.4
2017 Zewinger S, Kleber ME, Tragante V, McCubrey RO, Schmidt AF, Direk K, Laufs U, Werner C, Koenig W, Rothenbacher D, Mons U, Breitling LP, Brenner H, Jennings RT, Petrakis I, ... ... Hartiala JA, et al. Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study. The Lancet. Diabetes & Endocrinology. PMID 28566218 DOI: 10.1016/S2213-8587(17)30096-7  0.4
2017 Saleheen D, Zhao W, Young R, Nelson CP, Ho WK, Ferguson JF, Rasheed A, Ou K, Nurnberg ST, Bauer RC, Goel A, Do R, Stewart AFR, Hartiala J, Zhang W, et al. Loss of Cardio-Protective Effects at the ADAMTS7 Locus Due to Gene-Smoking Interactions. Circulation. PMID 28461624 DOI: 10.1161/Circulationaha.116.022069  0.4
2017 Hartiala J, Schwartzman WS, Gabbay J, Ghazalpour A, Bennett BJ, Allayee H. The Genetic Architecture of Coronary Artery Disease: Current Knowledge and Future Opportunities. Current Atherosclerosis Reports. 19: 6. PMID 28130654 DOI: 10.1007/S11883-017-0641-6  0.4
2016 Salehi P, Myint A, Kim YJ, Ge MX, Lavinsky J, Ho MK, Crow AL, Cruz C, Monges-Hernadez M, Wang J, Hartiala J, Zhang LI, Allayee H, Lusis AJ, Ohyama T, et al. Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice. Journal of the Association For Research in Otolaryngology : Jaro. PMID 27539716 DOI: 10.1007/S10162-016-0578-4  0.4
2016 Hartiala J, Breton CV, Tang WH, Lurmann F, Hazen SL, Gilliland FD, Allayee H. Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation. Journal of the American Heart Association. 5. PMID 27468926 DOI: 10.1161/Jaha.116.003947  0.4
2016 Hartiala JA, Tang WH, Wang Z, Crow AL, Stewart AF, Roberts R, McPherson R, Erdmann J, Willenborg C, Hazen SL, Allayee H. Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease. Nature Communications. 7: 10558. PMID 26822151 DOI: 10.1038/Ncomms10558  0.4
2015 Crow AL, Ohmen J, Wang J, Lavinsky J, Hartiala J, Li Q, Li X, Salehide P, Eskin E, Pan C, Lusis AJ, Allayee H, Friedman RA. The Genetic Architecture of Hearing Impairment in Mice: Evidence for Frequency Specific Genetic Determinants. G3 (Bethesda, Md.). PMID 26342000 DOI: 10.1534/G3.115.021592  0.4
2015 Schmidt RJ, Hansen RL, Hartiala J, Allayee H, Sconberg JL, Schmidt LC, Volk HE, Tassone F. Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study. Early Human Development. 91: 483-489. PMID 26073892 DOI: 10.1016/J.Earlhumdev.2015.05.008  0.4
2015 Zhou X, Crow AL, Hartiala J, Spindler TJ, Ghazalpour A, Barsky LW, Bennett BB, Parks BW, Eskin E, Jain R, Epstein JA, Lusis AJ, Adams GB, Allayee H. The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice. Stem Cell Reports. PMID 26050929 DOI: 10.1016/J.Stemcr.2015.05.008  0.4
2015 Jeong S, Patel N, Edlund CK, Hartiala J, Hazelett DJ, Itakura T, Wu PC, Avery RL, Davis JL, Flynn HW, Lalwani G, Puliafito CA, Wafapoor H, Hijikata M, Keicho N, et al. Identification of a Novel Mucin Gene HCG22 Associated With Steroid-Induced Ocular Hypertension. Investigative Ophthalmology & Visual Science. 56: 2737-48. PMID 25813999 DOI: 10.1167/Iovs.14-14803  0.4
2015 Do R, Stitziel NO, Won HH, Jørgensen AB, Duga S, Angelica Merlini P, Kiezun A, Farrall M, Goel A, Zuk O, Guella I, Asselta R, Lange LA, Peloso GM, Auer PL, ... ... Hartiala J, et al. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 518: 102-6. PMID 25487149 DOI: 10.1038/Nature13917  0.4
2014 Ren J, Xiang AH, Trigo E, Takayanagi M, Beale E, Lawrence JM, Hartiala J, Richey JM, Allayee H, Buchanan TA, Watanabe RM. Genetic variation in MTNR1B is associated with gestational diabetes mellitus and contributes only to the absolute level of beta cell compensation in Mexican Americans. Diabetologia. 57: 1391-9. PMID 24728128 DOI: 10.1007/S00125-014-3239-3  0.4
2014 Hartiala J, Bennett BJ, Tang WH, Wang Z, Stewart AF, Roberts R, McPherson R, Lusis AJ, Hazen SL, Allayee H. Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 1307-13. PMID 24675659 DOI: 10.1161/Atvbaha.114.303252  0.4
2013 Walker RW, Sinatra F, Hartiala J, Weigensberg M, Spruijt-Metz D, Alderete TL, Goran MI, Allayee H. Genetic and clinical markers of elevated liver fat content in overweight and obese Hispanic children. Obesity (Silver Spring, Md.). 21: E790-7. PMID 23804528 DOI: 10.1002/Oby.20523  0.4
2013 Reiner AP, Hartiala J, Zeller T, Bis JC, Dupuis J, Fornage M, Baumert J, Kleber ME, Wild PS, Baldus S, Bielinski SJ, Fontes JD, Illig T, Keating BJ, Lange LA, et al. Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. Human Molecular Genetics. 22: 3381-93. PMID 23620142 DOI: 10.1093/Hmg/Ddt189  0.4
2013 Zhou G, Marathe GK, Hartiala J, Hazen SL, Allayee H, Tang WH, McIntyre TM. Aspirin hydrolysis in plasma is a variable function of butyrylcholinesterase and platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2). The Journal of Biological Chemistry. 288: 11940-8. PMID 23508960 DOI: 10.1074/Jbc.M112.427674  0.4
2013 Chan K, Patel RS, Newcombe P, Nelson CP, Qasim A, Epstein SE, Burnett S, Vaccarino VL, Zafari AM, Shah SH, Anderson JL, Carlquist JF, Hartiala J, Allayee H, Hinohara K, et al. Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. Journal of the American College of Cardiology. 61: 957-70. PMID 23352782 DOI: 10.1016/J.Jacc.2012.10.051  0.4
2012 van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi J, Paul DS, Elling U, Allayee H, Li X, Radhakrishnan A, Tan ST, Voss K, Weichenberger CX, Albers CA, ... ... Hartiala J, et al. Seventy-five genetic loci influencing the human red blood cell. Nature. 492: 369-75. PMID 23222517 DOI: 10.1038/Nature11677  0.4
2012 Tang WH, Hartiala J, Fan Y, Wu Y, Stewart AF, Erdmann J, Kathiresan S, Roberts R, McPherson R, Allayee H, Hazen SL. Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 2803-12. PMID 22982463 DOI: 10.1161/Atvbaha.112.253930  0.4
2012 Patel RS, Sun YV, Hartiala J, Veledar E, Su S, Sher S, Liu YX, Rahman A, Patel R, Rab ST, Vaccarino V, Zafari AM, Samady H, Tang WH, Allayee H, et al. Association of a genetic risk score with prevalent and incident myocardial infarction in subjects undergoing coronary angiography. Circulation. Cardiovascular Genetics. 5: 441-9. PMID 22767652 DOI: 10.1161/Circgenetics.111.960229  0.4
2012 Schmidt RJ, Tancredi DJ, Ozonoff S, Hansen RL, Hartiala J, Allayee H, Schmidt LC, Tassone F, Hertz-Picciotto I. Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. The American Journal of Clinical Nutrition. 96: 80-9. PMID 22648721 DOI: 10.3945/Ajcn.110.004416  0.4
2012 Hartiala J, Gilliam E, Vikman S, Campos H, Allayee H. Association of PLA2G4A with myocardial infarction is modulated by dietary PUFAs. The American Journal of Clinical Nutrition. 95: 959-65. PMID 22378731 DOI: 10.3945/Ajcn.111.032094  0.4
2012 Tang WH, Wu Y, Hartiala J, Fan Y, Stewart AF, Roberts R, McPherson R, Fox PL, Allayee H, Hazen SL. Clinical and genetic association of serum ceruloplasmin with cardiovascular risk. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 516-22. PMID 22075249 DOI: 10.1161/Atvbaha.111.237040  0.4
2011 Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y, Lopez LM, Mägi R, Meacham S, Okada Y, Pirastu N, ... ... Hartiala J, et al. New gene functions in megakaryopoiesis and platelet formation. Nature. 480: 201-8. PMID 22139419 DOI: 10.1038/Nature10659  0.4
2011 Schmidt RJ, Hansen RL, Hartiala J, Allayee H, Schmidt LC, Tancredi DJ, Tassone F, Hertz-Picciotto I. Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism. Epidemiology (Cambridge, Mass.). 22: 476-85. PMID 21610500 DOI: 10.1097/Ede.0B013E31821D0E30  0.4
2011 Mendoza-Fandino GA, Gee JM, Ben-Dor S, Gonzalez-Quevedo C, Lee K, Kobayashi Y, Hartiala J, Myers RM, Leal SM, Allayee H, Patel PI. A novel g.-1258G>A mutation in a conserved putative regulatory element of PAX9 is associated with autosomal dominant molar hypodontia. Clinical Genetics. 80: 265-72. PMID 21443745 DOI: 10.1111/J.1399-0004.2010.01529.X  0.4
2011 Lettre G, Palmer CD, Young T, Ejebe KG, Allayee H, Benjamin EJ, Bennett F, Bowden DW, Chakravarti A, Dreisbach A, Farlow DN, Folsom AR, Fornage M, Forrester T, Fox E, ... ... Hartiala J, et al. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. Plos Genetics. 7: e1001300. PMID 21347282 DOI: 10.1371/Journal.Pgen.1001300  0.4
2011 Stephensen CB, Armstrong P, Newman JW, Pedersen TL, Legault J, Schuster GU, Kelley D, Vikman S, Hartiala J, Nassir R, Seldin MF, Allayee H. ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation. Journal of Lipid Research. 52: 991-1003. PMID 21296957 DOI: 10.1194/Jlr.P012864  0.4
2011 Hartiala J, Li D, Conti DV, Vikman S, Patel Y, Tang WH, Brennan ML, Newman JW, Stephensen CB, Armstrong P, Hazen SL, Allayee H. Genetic contribution of the leukotriene pathway to coronary artery disease. Human Genetics. 129: 617-27. PMID 21293878 DOI: 10.1007/S00439-011-0963-3  0.4
2011 Qi L, Ma J, Qi Q, Hartiala J, Allayee H, Campos H. Genetic risk score and risk of myocardial infarction in Hispanics. Circulation. 123: 374-80. PMID 21242481 DOI: 10.1161/Circulationaha.110.976613  0.4
2010 Nicholls SJ, Tang WH, Scoffone H, Brennan DM, Hartiala J, Allayee H, Hazen SL. Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy. Journal of Lipid Research. 51: 3055-61. PMID 20601648 DOI: 10.1194/Jlr.M008961  0.4
2009 Li X, Shu YH, Xiang AH, Trigo E, Kuusisto J, Hartiala J, Swift AJ, Kawakubo M, Stringham HM, Bonnycastle LL, Lawrence JM, Laakso M, Allayee H, Buchanan TA, Watanabe RM. Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose. Diabetes. 58: 2946-53. PMID 19741163 DOI: 10.2337/Db09-0228  0.4
2009 Vikman S, Brena RM, Armstrong P, Hartiala J, Stephensen CB, Allayee H. Functional analysis of 5-lipoxygenase promoter repeat variants. Human Molecular Genetics. 18: 4521-9. PMID 19717473 DOI: 10.1093/Hmg/Ddp414  0.4
2009 Shu YH, Hartiala J, Xiang AH, Trigo E, Lawrence JM, Allayee H, Buchanan TA, Bottini N, Watanabe RM. Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans. The Journal of Clinical Endocrinology and Metabolism. 94: 4094-102. PMID 19622628 DOI: 10.1210/Jc.2008-2751  0.4
2009 Li X, Allayee H, Xiang AH, Trigo E, Hartiala J, Lawrence JM, Buchanan TA, Watanabe RM. Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans. Obesity (Silver Spring, Md.). 17: 729-36. PMID 19148120 DOI: 10.1038/Oby.2008.593  0.4
2009 Orrú V, Tsai SJ, Rueda B, Fiorillo E, Stanford SM, Dasgupta J, Hartiala J, Zhao L, Ortego-Centeno N, D'Alfonso S, Arnett FC, Wu H, Gonzalez-Gay MA, Tsao BP, et al. A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Human Molecular Genetics. 18: 569-79. PMID 18981062 DOI: 10.1093/Hmg/Ddn363  0.4
2008 Allayee H, Baylin A, Hartiala J, Wijesuriya H, Mehrabian M, Lusis AJ, Campos H. Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction. The American Journal of Clinical Nutrition. 88: 934-40. PMID 18842779 DOI: 10.1093/Ajcn/88.4.934  0.4
2008 Allayee H. Non-conventional genetic risk factors for cardiovascular disease. World Review of Nutrition and Dietetics. 98: 62-76. PMID 18806462 DOI: 10.1159/000152922  0.8
2008 Mehrabian M, Schulthess FT, Nebohacova M, Castellani LW, Zhou Z, Hartiala J, Oberholzer J, Lusis AJ, Maedler K, Allayee H. Identification of ALOX5 as a gene regulating adiposity and pancreatic function. Diabetologia. 51: 978-88. PMID 18421434 DOI: 10.1007/S00125-008-1002-3  0.4
2008 Assimes TL, Knowles JW, Priest JR, Basu A, Volcik KA, Southwick A, Tabor HK, Hartiala J, Allayee H, Grove ML, Tabibiazar R, Sidney S, Fortmann SP, Go A, Hlatky M, et al. Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease. Human Genetics. 123: 399-408. PMID 18369664 DOI: 10.1007/S00439-008-0489-5  0.4
2008 Chang AJ, Kline MM, Currie Y, Perez MO, Hartiala J, Wijesuriya H, Buchanan TA, Watanabe RM, Allayee H. Allgrove syndrome in a Mexican American family is caused by an ancestral mutation derived from North Africa. Clinical Genetics. 73: 385-7. PMID 18261130 DOI: 10.1111/J.1399-0004.2008.00965.X  0.4
2008 Black MH, Fingerlin TE, Allayee H, Zhang W, Xiang AH, Trigo E, Hartiala J, Lehtinen AB, Haffner SM, Bergman RN, McEachin RC, Kjos SL, Lawrence JM, Buchanan TA, Watanabe RM. Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans. Diabetes. 57: 1048-56. PMID 18162503 DOI: 10.2337/Db07-0848  0.4
2007 Allayee H, Hartiala J, Lee W, Mehrabian M, Irvin CG, Conti DV, Lima JJ. The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics. Chest. 132: 868-74. PMID 17646220 DOI: 10.1378/Chest.07-0831  0.4
2007 Watanabe RM, Allayee H, Xiang AH, Trigo E, Hartiala J, Lawrence JM, Buchanan TA. Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans. Diabetes. 56: 1481-5. PMID 17317761 DOI: 10.2337/Db06-1682  0.4
2007 Mendoza G, Pemberton TJ, Lee K, Scarel-Caminaga R, Mehrian-Shai R, Gonzalez-Quevedo C, Ninis V, Hartiala J, Allayee H, Snead ML, Leal SM, Line SR, Patel PI. A new locus for autosomal dominant amelogenesis imperfecta on chromosome 8q24.3. Human Genetics. 120: 653-62. PMID 17024372 DOI: 10.1007/S00439-006-0246-6  0.4
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