| Year |
Citation |
Score |
| 2020 |
Duvall B, Zimmermann SC, Gao RD, Thomas AG, Kalčic F, Veeravalli V, Elgogary A, Rais R, Rojas C, Le A, Slusher BS, Tsukamoto T. Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker. Bioorganic & Medicinal Chemistry. 28: 115698. PMID 33069080 DOI: 10.1016/J.Bmc.2020.115698 |
0.32 |
|
| 2020 |
Giancola JB, Bonifazi A, Cao J, Ku T, Haraczy AJ, Lam J, Rais R, Coggiano MA, Tanda G, Newman AH. Structure-activity relationships for a series of (Bis(4-fluorophenyl)methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the dopamine transporter: Bioisosteric replacement of the piperazine improves metabolic stability. European Journal of Medicinal Chemistry. 208: 112674. PMID 32947229 DOI: 10.1016/J.Ejmech.2020.112674 |
0.362 |
|
| 2020 |
Khoury ES, Sharma A, Ramireddy RR, Thomas AG, Alt J, Fowler A, Rais R, Tsukamoto T, Blue ME, Slusher B, Kannan S, Kannan RM. Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome. Theranostics. 10: 5736-5748. PMID 32483415 DOI: 10.7150/Thno.41714 |
0.375 |
|
| 2020 |
Oh MH, Sun IH, Zhao L, Leone RD, Sun IM, Xu W, Collins SL, Tam AJ, Blosser RL, Patel CH, Englert JM, Arwood ML, Wen J, Chan-Li Y, Tenora L, ... ... Rais R, et al. Targeting glutamine metabolism enhances tumor specific immunity by modulating suppressive myeloid cells. The Journal of Clinical Investigation. PMID 32324593 DOI: 10.1172/Jci131859 |
0.338 |
|
| 2020 |
Sala M, Hollinger KR, Thomas AG, Dash RP, Tallon C, Veeravalli V, Lovell L, Kögler M, Hrebabecky H, Prochazkova E, Nesuta O, Donoghue A, Lam J, Rais R, Rojas C, et al. Novel human neutral sphingomyelinase 2 inhibitors as potential therapeutics for Alzheimer disease. Journal of Medicinal Chemistry. PMID 32298582 DOI: 10.1021/Acs.Jmedchem.0C00278 |
0.344 |
|
| 2020 |
Powell J, Leone R, Oh M, Rais R, Majer P, Slusher B. Abstract IA10: Targeting glutamine metabolism as a means of enhancing immunotherapy for cancer Clinical Cancer Research. 26. DOI: 10.1158/1557-3265.Aacrahns19-Ia10 |
0.348 |
|
| 2019 |
Leone RD, Zhao L, Englert JM, Sun IM, Oh MH, Sun IH, Arwood ML, Bettencourt IA, Patel CH, Wen J, Tam A, Blosser RL, Prchalova E, Alt J, Rais R, et al. Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Science (New York, N.Y.). PMID 31699883 DOI: 10.1126/Science.Aav2588 |
0.32 |
|
| 2019 |
Slack RD, Ku T, Cao J, Giancola J, Bonifazi A, Loland CJ, Gadiano A, Lam J, Rais R, Slusher BS, Coggiano M, Tanda G, Newman AH. Structure-Activity Relationships for a series of bis(4-fluorophenyl)methyl)sulfinyl)alkyl alicyclic amines at the dopamine transporter: functionalizing the terminal nitrogen affects affinity, selectivity and metabolic stability. Journal of Medicinal Chemistry. PMID 31661268 DOI: 10.1021/Acs.Jmedchem.9B01188 |
0.342 |
|
| 2019 |
Lemberg KM, Zhao L, Wu Y, Veeravalli V, Alt J, Aguilar JMH, Dash RP, Lam J, Tenora L, Rodriguez C, Nedelcovych MT, Brayton C, Majer P, Blakeley JO, Rais R, et al. The novel glutamine antagonist prodrug JHU395 has antitumor activity in malignant peripheral nerve sheath tumor. Molecular Cancer Therapeutics. PMID 31594823 DOI: 10.1158/1535-7163.Mct-19-0319 |
0.342 |
|
| 2019 |
Shaik AB, Kumar V, Bonifazi A, Guerrero A, Cemaj S, Gadiano A, Lam J, Xi ZX, Rais R, Slusher BS, Newman AH. Investigation of novel primary and secondary pharmacophores, and 3-substitution in the linking chain of a series of highly selective and bitopic dopamine D3 receptor antagonists and partial agonists. Journal of Medicinal Chemistry. PMID 31526003 DOI: 10.1021/Acs.Jmedchem.9B00607 |
0.35 |
|
| 2019 |
Dash RP, Tichý T, Veeravalli V, Lam J, Alt J, Wu Y, Tenora L, Majer P, Slusher BS, Rais R. Enhanced oral bioavailability of 2-(phosphonomethyl)-pentanedioic acid (2-PMPA) from its (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL) based prodrugs. Molecular Pharmaceutics. PMID 31503493 DOI: 10.1021/Acs.Molpharmaceut.9B00637 |
0.34 |
|
| 2019 |
Hanaford AR, Alt J, Rais R, Wang SZ, Kaur H, Thorek DLJ, Eberhart CG, Slusher BS, Martin AM, Raabe EH. Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma. Translational Oncology. 12: 1314-1322. PMID 31340195 DOI: 10.1016/J.Tranon.2019.05.013 |
0.351 |
|
| 2019 |
Rojas C, Sala M, Thomas AG, Datta Chaudhuri A, Yoo SW, Li Z, Dash RP, Rais R, Haughey N, Nencka R, Slusher B. A novel and potent brain penetrant inhibitor of extracellular vesicle release. British Journal of Pharmacology. PMID 31273753 DOI: 10.1111/Bph.14789 |
0.326 |
|
| 2019 |
Battiti FO, Cemaj SL, Guerrero AM, Shaik AB, Lam J, Rais R, Slusher BS, Deschamps JR, Imler GH, Newman AH, Bonifazi A. The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D Receptor (DR) Selective Agonists. Journal of Medicinal Chemistry. PMID 31257877 DOI: 10.1021/Acs.Jmedchem.9B00702 |
0.318 |
|
| 2019 |
Nedelcovych MT, Kim BH, Zhu X, Lovell LE, Manning AA, Kelschenbach J, Hadas E, Chao W, Prchalová E, Dash RP, Wu Y, Alt J, Thomas AG, Rais R, Kamiya A, et al. Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 31209775 DOI: 10.1007/S11481-019-09859-W |
0.332 |
|
| 2019 |
Jordan CJ, Humburg B, Rice M, Bi GH, You ZB, Shaik AB, Cao J, Bonifazi A, Gadiano A, Rais R, Slusher B, Newman AH, Xi ZX. The highly selective dopamine DR antagonist, RVK4-40, attenuates oxycodone reward and augments analgesia in rodents. Neuropharmacology. PMID 30974107 DOI: 10.1016/J.Neuropharm.2019.04.003 |
0.309 |
|
| 2019 |
Stepanek O, Hin N, Thomas AG, Dash RP, Alt J, Rais R, Rojas C, Slusher BS, Tsukamoto T. Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold. European Journal of Medicinal Chemistry. 170: 276-289. PMID 30921693 DOI: 10.1016/J.Ejmech.2019.03.015 |
0.365 |
|
| 2019 |
Tenora L, Alt J, Dash RP, Gadiano AJ, Novotna K, Veeravalli V, Lam J, Kirkpatrick QR, Lemberg K, Majer P, Rais R, Slusher BS. Tumor-targeted delivery of 6-Diazo-5-oxo-L-norleucine (DON) using substituted acetylated lysine prodrugs. Journal of Medicinal Chemistry. PMID 30892035 DOI: 10.1021/Acs.Jmedchem.8B02009 |
0.363 |
|
| 2019 |
Wang SZ, Poore B, Alt J, Price A, Allen S, Orr B, Rais R, Slusher B, Eberhart C, Raabe EH, Rubens JH. Abstract 5267: Unbiased metabolic profiling of atypical teratoid/rhabdoid tumors predicts sensitivity to the glutamine metabolic inhibitor 6-diazo-5-oxo-L-norleucine Cancer Research. 79: 5267-5267. DOI: 10.1158/1538-7445.Sabcs18-5267 |
0.35 |
|
| 2019 |
Zhao L, Arwood M, Oh M, Xu W, Sun I, Sun I, Patel C, Leone R, Alt J, Rais R, Slusher B, Powell JD. Abstract 4376: Targeting glutamine metabolism disables Warburg physiology by inhibiting proximal glycolysis and Krebs cycle rewiring Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-4376 |
0.301 |
|
| 2019 |
Rais R, Alt J, Dash R, Tenora L, Majer P, Slusher BS. Abstract 3620: Tumor targeted delivery of glutamine antagonist: Use of CES1-/-mice Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3620 |
0.307 |
|
| 2019 |
Oh M, Travers M, Brown S, Zhao L, Sun I, Sun I, Arwood M, Xu W, Collins S, Leone R, Prchalova E, Rais R, Slusher B, Horton M, Zahnow C, et al. Abstract LB-022: Targeting glutamine metabolism as a mean of treating a murine model of ovarian cancer and ascites development Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Lb-022 |
0.362 |
|
| 2019 |
Wang S, Poore B, Alt J, Price A, Allen S, Orr B, Rais R, Slusher B, Eberhart C, Raabe E, Rubens J. ATRT-04. UNBIASED METABOLIC PROFILING OF ATYPICAL TERATOID/RHABDOID TUMORS PREDICTS SENSITIVITY TO GLUTAMINE METABOLIC INHIBITORS Neuro-Oncology. 21: ii63-ii63. DOI: 10.1093/Neuonc/Noz036.003 |
0.307 |
|
| 2018 |
Rojas C, Barnaeva E, Thomas AG, Hu X, Southall N, Marugan J, Chaudhuri AD, Yoo SW, Hin N, Stepanek O, Wu Y, Zimmermann SC, Gadiano AG, Tsukamoto T, Rais R, et al. DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Scientific Reports. 8: 17715. PMID 30531925 DOI: 10.1038/S41598-018-36144-2 |
0.337 |
|
| 2018 |
Lemberg KM, Vornov JJ, Rais R, Slusher BS. We're Not "DON" Yet: Optimal Dosing and Prodrug Delivery of . Molecular Cancer Therapeutics. 17: 1824-1832. PMID 30181331 DOI: 10.1158/1535-7163.Mct-17-1148 |
0.376 |
|
| 2018 |
Zimmermann SC, Tichy T, Vavra J, Dash RP, Slusher CE, Gadiano AJ, Wu Y, Jančařík A, Tenora L, Monincova L, Prchalova E, Riggins GJ, Majer P, Slusher BS, Rais R. N-substituted prodrugs of mebendazole provide improved aqueous solubility and oral bioavailability in mice and dogs. Journal of Medicinal Chemistry. PMID 29648826 DOI: 10.1021/Acs.Jmedchem.7B01792 |
0.324 |
|
| 2018 |
Soomro I, Sun Y, Li Z, Diggs L, Hatzivassiliou G, Thomas AG, Rais R, Slusher BS, Somlo S, Skolnik EY. Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. PMID 29420817 DOI: 10.1093/Ndt/Gfx349 |
0.307 |
|
| 2018 |
Leone R, Englert J, Sun I, Oh M, Alt J, Sun I, Tam AJ, Majer P, Rais R, Slusher B, Powell J. Abstract 4963: Targeting glutamine metabolism as a means of enhancing antitumor T-cell responses Cancer Research. 78: 4963-4963. DOI: 10.1158/1538-7445.Am2018-4963 |
0.331 |
|
| 2018 |
Oh M, Sun I, Zhao L, Sun I, Xu W, Patel C, Leone R, Tam AJ, Englert J, Majer P, Rais R, Slusher B, Horton MR, Powell JD. Abstract 4730: Targeting glutamine metabolism enhances tumor specific immunity by inhibiting the generation and function of suppressive myeloid cells Cancer Research. 78: 4730-4730. DOI: 10.1158/1538-7445.Am2018-4730 |
0.35 |
|
| 2018 |
Lemberg K, Wu Y, Alt J, Zhao L, Gadiano AJ, Rodriguez C, Rais R, Majer P, Blakeley J, Slusher B. Abstract 3524: Novel prodrugs of the glutamine antagonist 6-diazo-5-oxo-norleucine (DON) as treatment for malignant peripheral nerve sheath tumor Cancer Research. 78: 3524-3524. DOI: 10.1158/1538-7445.Am2018-3524 |
0.369 |
|
| 2018 |
Maxwell MJ, Poore B, Hanaford A, Alt J, Rais R, Slusher BS, Eberhart CG, Raabe EH. Abstract 3521: Glutamine metabolic inhibition synergizes with L-asparaginase in MYCN-amplified neuroblastoma Cancer Research. 78: 3521-3521. DOI: 10.1158/1538-7445.Am2018-3521 |
0.364 |
|
| 2018 |
Wang SZ, Poore B, Alt J, Rais R, Allen S, Orr B, Slusher B, Eberhart C, Raabe E, Rubens J. Abstract 3519: Disrupting glutamine metabolism depletes glutathione and sensitizes atypical teratoid/rhabdoid tumor to carboplatin Cancer Research. 78: 3519-3519. DOI: 10.1158/1538-7445.Am2018-3519 |
0.327 |
|
| 2017 |
Tunstall BJ, Ho CP, Cao J, Vendruscolo JCM, Schmeichel BE, Slack RD, Tanda G, Gadiano AJ, Rais R, Slusher BS, Koob GF, Newman AH, Vendruscolo LF. Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats. Neuropharmacology. 131: 96-103. PMID 29217282 DOI: 10.1016/J.Neuropharm.2017.12.006 |
0.309 |
|
| 2017 |
Prasad Dash R, Rais R, Srinivas NR. Chirality and neuropsychiatric drugs - An update on stereoselective disposition and clinical pharmacokinetics of bupropion. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-41. PMID 28876959 DOI: 10.1080/00498254.2017.1376765 |
0.313 |
|
| 2017 |
Nedelcovych M, Dash RP, Tenora L, Zimmermann SC, Gadiano AJ, Garrett C, Alt J, Hollinger KR, Pommier E, Jančařík A, Rojas C, Thomas AG, Wu Y, Wozniak K, Majer P, ... ... Rais R, et al. Enhanced Brain Delivery of (2-(phosphonomethyl)pentanedioic acid) following Intranasal Administration of its γ-substituted Ester Prodrugs. Molecular Pharmaceutics. PMID 28763226 DOI: 10.1021/Acs.Molpharmaceut.7B00231 |
0.346 |
|
| 2017 |
Nedelcovych MT, Tenora L, Kim BH, Kelschenbach J, Chao W, Hadas E, Jančařík A, Prchalová E, Zimmermann SC, Dash RP, Gadiano AJ, Garrett C, Furtmüller G, Oh B, Brandacher G, ... ... Rais R, et al. N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-L-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders. Journal of Medicinal Chemistry. PMID 28759224 DOI: 10.1021/Acs.Jmedchem.7B00966 |
0.326 |
|
| 2017 |
Rais R, Vávra J, Tichý T, Dash RP, Gadiano AJ, Tenora L, Monincova L, Barinka C, Alt J, Zimmermann SC, Slusher CE, Wu Y, Wozniak K, Majer P, Tsukamoto T, et al. Discovery of a para-acetoxy-benzyl ester prodrug of a hydroxamate-based Glutamate Carboxypeptidase II inhibitor as oral therapy for neuropathic pain. Journal of Medicinal Chemistry. PMID 28759215 DOI: 10.1021/Acs.Jmedchem.7B00825 |
0.367 |
|
| 2017 |
Dash RP, Rais R, Srinivas NR. Ponesimod, a selective sphingosine 1-phosphate (S1P1) receptor modulator for autoimmune diseases: Review of clinical pharmacokinetics and drug disposition. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-32. PMID 28489480 DOI: 10.1080/00498254.2017.1329568 |
0.321 |
|
| 2017 |
Dash RP, Rais R, Srinivas NR. Stereoselective and non-stereoselective pharmacokinetics of rabeprazole - An overview. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-32. PMID 28294690 DOI: 10.1080/00498254.2017.1307470 |
0.306 |
|
| 2017 |
Date AA, Rais R, Babu T, Ortiz J, Kanvinde P, Thomas AG, Zimmermann SC, Gadiano AJ, Halpert G, Slusher BS, Ensign LM. Local enema treatment to inhibit FOLH1/GCPII as a novel therapy for inflammatory bowel disease. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 28159515 DOI: 10.1016/J.Jconrel.2017.01.036 |
0.329 |
|
| 2017 |
Powell JD, Leone R, Englert J, Rais R, Slusher B. Abstract SY33-01: Targeting metabolism to enhance immunotherapy Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Sy33-01 |
0.354 |
|
| 2017 |
Leone RD, Englert JM, Oh M, Cheng C, Rais R, Slusher B, Powell JD. Abstract 573: Metabolism as checkpoint: Induction of anti-tumor immune response with the novel glutamine antagonist JHU-083 Cancer Research. 77: 573-573. DOI: 10.1158/1538-7445.Am2017-573 |
0.348 |
|
| 2016 |
Cao J, Slack RD, Bakare OM, Burzynski C, Rais R, Slusher BS, Kopajtic T, Bonifazi A, Ellenberger MP, Yano H, He Y, Bi GH, Xi ZX, Loland CJ, Newman AH. Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors. Journal of Medicinal Chemistry. 59: 10676-10691. PMID 27933960 DOI: 10.1021/Acs.Jmedchem.6B01373 |
0.326 |
|
| 2016 |
Rais R, Jancarik A, Tenora L, Nedelcovych M, Alt J, Englert J, Rojas C, Le A, Elgogary A, Tan J, Monincova L, Pate K, Adams RJ, Ferraris DV, Powell JD, et al. Discovery of 6-Diazo-5-oxo-L-norleucine (DON) prodrugs with enhanced CSF delivery in monkeys: a potential treatment for glioblastoma. Journal of Medicinal Chemistry. PMID 27560860 DOI: 10.1021/Acs.Jmedchem.6B01069 |
0.379 |
|
| 2016 |
Elgogary A, Xu Q, Poore B, Alt J, Zimmermann SC, Zhao L, Fu J, Chen B, Xia S, Liu Y, Neisser M, Nguyen C, Lee R, Park JK, Reyes J, ... ... Rais R, et al. Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 27559084 DOI: 10.1073/Pnas.1611406113 |
0.344 |
|
| 2016 |
Rais R, Jiang W, Zhai H, Wozniak KM, Stathis M, Hollinger KR, Thomas AG, Rojas C, Vornov JJ, Marohn M, Li X, Slusher BS. FOLH1/GCPII is elevated in IBD patients, and its inhibition ameliorates murine IBD abnormalities. Jci Insight. 1. PMID 27536732 DOI: 10.1172/Jci.Insight.88634 |
0.332 |
|
| 2016 |
Kumar V, Bonifazi A, Ellenberger MP, Keck TM, Pommier E, Rais R, Slusher BS, Gardner E, You ZB, Xi ZX, Newman AH. Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment. Journal of Medicinal Chemistry. PMID 27508895 DOI: 10.1021/Acs.Jmedchem.6B00860 |
0.358 |
|
| 2016 |
Vornov JJ, Hollinger KR, Jackson PF, Wozniak KM, Farah MH, Majer P, Rais R, Slusher BS. Still NAAG'ing After All These Years: The Continuing Pursuit of GCPII Inhibitors. Advances in Pharmacology (San Diego, Calif.). 76: 215-55. PMID 27288079 DOI: 10.1016/Bs.Apha.2016.01.007 |
0.31 |
|
| 2016 |
Rojas C, Alt J, Ator NA, Wilmoth H, Rais R, Hin N, DeVivo M, Popiolek M, Tsukamoto T, Slusher BS. Oral administration of D-alanine in monkeys robustly increases plasma and cerebrospinal fluid levels but experimental D-amino acid oxidase inhibitors had minimal effect. Journal of Psychopharmacology (Oxford, England). PMID 27287825 DOI: 10.1177/0269881116652586 |
0.316 |
|
| 2016 |
Novakova Z, Wozniak K, Jancarik A, Rais R, Wu Y, Pavlicek J, Ferraris DV, Havlinova B, Ptacek J, Vavra J, Hin N, Rojas C, Majer P, Slusher BS, Tsukamoto T, et al. Unprecedented binding mode of hydroxamate-based inhibitors of glutamate carboxypeptidase II: structural characterization and biological activity. Journal of Medicinal Chemistry. PMID 27074627 DOI: 10.1021/Acs.Jmedchem.5B01806 |
0.337 |
|
| 2016 |
Hin N, Duvall B, Berry JF, Ferraris DV, Rais R, Alt J, Rojas C, Slusher BS, Tsukamoto T. d-Amino acid oxidase inhibitors based on the 5-hydroxy-1,2,4-triazin-6(1H)-one scaffold. Bioorganic & Medicinal Chemistry Letters. PMID 26965861 DOI: 10.1016/J.Bmcl.2016.02.068 |
0.359 |
|
| 2016 |
Majer P, Jančarík A, Krečmerová M, Tichý T, Tenora L, Wozniak K, Wu Y, Pommier E, Ferraris DV, Rais R, Slusher BS. Discovery of orally available prodrugs of the Glutamate Carboxypeptidase II (GCP II) inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA). Journal of Medicinal Chemistry. PMID 26930119 DOI: 10.1021/Acs.Jmedchem.6B00062 |
0.336 |
|
| 2016 |
Englert J, Cheng C, Leone R, Majer P, Rais R, Slusher B, Powell J. Abstract 1035: Targeting glutamine metabolism with the novel inhibitor JHU-083 inhibits tumor growth and alters the tumor immune microenvironment Cancer Research. 76: 1035-1035. DOI: 10.1158/1538-7445.Am2016-1035 |
0.368 |
|
| 2015 |
Rojas C, Alt J, Ator NA, Thomas AG, Wu Y, Hin N, Wozniak K, Ferraris D, Rais R, Tsukamoto T, Slusher BS. D-Amino Acid Oxidase Inhibition Increases D-Serine Plasma Levels in Mouse But not Monkey or Dog. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26471255 DOI: 10.1038/Npp.2015.319 |
0.326 |
|
| 2015 |
Hin N, Duvall B, Ferraris D, Alt J, Thomas AG, Rais R, Rojas C, Wu Y, Wozniak KM, Slusher BS, Tsukamoto T. 6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Novel D-Amino Acid Oxidase Inhibitors. Journal of Medicinal Chemistry. PMID 26309148 DOI: 10.1021/Acs.Jmedchem.5B00482 |
0.325 |
|
| 2015 |
Boateng CA, Bakare OM, Zhan J, Banala AK, Burzynski C, Pommier E, Keck TM, Donthamsetti P, Javitch JA, Rais R, Slusher BS, Xi ZX, Newman AH. High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice. Journal of Medicinal Chemistry. 58: 6195-213. PMID 26203768 DOI: 10.1021/Acs.Jmedchem.5B00776 |
0.368 |
|
| 2015 |
Rais R, Wozniak K, Wu Y, Niwa M, Stathis M, Alt J, Giroux M, Sawa A, Rojas C, Slusher BS. Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration. Plos One. 10: e0131861. PMID 26151906 DOI: 10.1371/Journal.Pone.0131861 |
0.314 |
|
| 2015 |
Keck TM, Banala AK, Slack RD, Burzynski C, Bonifazi A, Okunola-Bakare OM, Moore M, Deschamps JR, Rais R, Slusher BS, Newman AH. Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands. Bioorganic & Medicinal Chemistry. 23: 4000-12. PMID 25650314 DOI: 10.1016/J.Bmc.2015.01.017 |
0.363 |
|
| 2014 |
Zimmermann SC, Rais R, Alt J, Burzynski C, Slusher BS, Tsukamoto T. Structure-Metabolism Relationships in the Glucuronidation of d-Amino Acid Oxidase Inhibitors. Acs Medicinal Chemistry Letters. 5: 1251-3. PMID 25408840 DOI: 10.1021/Ml500335Z |
0.353 |
|
| 2014 |
Ferraris DV, Majer P, Ni C, Slusher CE, Rais R, Wu Y, Wozniak KM, Alt J, Rojas C, Slusher BS, Tsukamoto T. δ-Thiolactones as prodrugs of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors. Journal of Medicinal Chemistry. 57: 243-7. PMID 24354364 DOI: 10.1021/Jm401703A |
0.347 |
|
| 2014 |
Rais R, Rojas C, Wozniak K, Wu Y, Zhao M, Tsukamoto T, Rudek MA, Slusher BS. Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA). Journal of Pharmaceutical and Biomedical Analysis. 88: 162-9. PMID 24055700 DOI: 10.1016/J.Jpba.2013.08.028 |
0.347 |
|
| 2013 |
Vornov JJ, Wozniak KM, Wu Y, Rojas C, Rais R, Slusher BS. Pharmacokinetics and pharmacodynamics of the glutamate carboxypeptidase II inhibitor 2-MPPA show prolonged alleviation of neuropathic pain through an indirect mechanism. The Journal of Pharmacology and Experimental Therapeutics. 346: 406-13. PMID 23776202 DOI: 10.1124/Jpet.113.205039 |
0.345 |
|
| 2012 |
Berry JF, Ferraris DV, Duvall B, Hin N, Rais R, Alt J, Thomas AG, Rojas C, Hashimoto K, Slusher BS, Tsukamoto T. Synthesis and SAR of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones as Inhibitors of D-Amino Acid Oxidase. Acs Medicinal Chemistry Letters. 3: 839-843. PMID 23243487 DOI: 10.1021/Ml300212A |
0.348 |
|
| 2012 |
Shukla K, Ferraris DV, Thomas AG, Stathis M, Duvall B, Delahanty G, Alt J, Rais R, Rojas C, Gao P, Xiang Y, Dang CV, Slusher BS, Tsukamoto T. Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. Journal of Medicinal Chemistry. 55: 10551-63. PMID 23151085 DOI: 10.1021/Jm301191P |
0.383 |
|
| 2012 |
Wozniak KM, Wu Y, Vornov JJ, Lapidus R, Rais R, Rojas C, Tsukamoto T, Slusher BS. The orally active glutamate carboxypeptidase II inhibitor E2072 exhibits sustained nerve exposure and attenuates peripheral neuropathy. The Journal of Pharmacology and Experimental Therapeutics. 343: 746-54. PMID 22988061 DOI: 10.1124/Jpet.112.197665 |
0.321 |
|
| 2012 |
Rais R, Hoover R, Wozniak K, Rudek MA, Tsukamoto T, Alt J, Rojas C, Slusher BS. Reversible disulfide formation of the glutamate carboxypeptidase II inhibitor E2072 results in prolonged systemic exposures in vivo. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 2315-23. PMID 22949627 DOI: 10.1124/Dmd.112.046821 |
0.313 |
|
| 2012 |
Rais R, Thomas AG, Wozniak K, Wu Y, Jaaro-Peled H, Sawa A, Strick CA, Engle SJ, Brandon NJ, Rojas C, Slusher BS, Tsukamoto T. Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 2067-73. PMID 22837388 DOI: 10.1124/Dmd.112.046482 |
0.314 |
|
| 2011 |
Rais R, Fletcher S, Polli JE. Synthesis and in vitro evaluation of gabapentin prodrugs that target the human apical sodium-dependent bile acid transporter (hASBT). Journal of Pharmaceutical Sciences. 100: 1184-95. PMID 20848648 DOI: 10.1002/Jps.22332 |
0.582 |
|
| 2010 |
Rais R, Acharya C, MacKerell AD, Polli JE. Structural determinants for transport across the intestinal bile acid transporter using C-24 bile acid conjugates Molecular Pharmaceutics. 7: 2240-2254. PMID 20939504 DOI: 10.1021/Mp100233V |
0.567 |
|
| 2010 |
Rais R, Acharya C, Tririya G, MacKerell AD, Polli JE. Molecular switch controlling the binding of anionic bile acid conjugates to human apical sodium-dependent bile acid transporter Journal of Medicinal Chemistry. 53: 4749-4760. PMID 20504026 DOI: 10.1021/Jm1003683 |
0.539 |
|
| 2008 |
Rais R, Gonzalez PM, Zheng X, Wring SA, Polli JE. Method to screen substrates of apical sodium-dependent bile acid transporter. The Aaps Journal. 10: 596-605. PMID 19085111 DOI: 10.1208/S12248-008-9069-9 |
0.64 |
|
| Show low-probability matches. |