Randy Strong - Publications

Affiliations: 
The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States 
Area:
Pharmacology, Pharmaceutical Chemistry

55/132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Soto-Piña AE, Franklin C, Rani CSS, Fernandez E, Cardoso-Peña E, Benítez-Arciniega AD, Gottlieb H, Hinojosa-Laborde C, Strong R. Dexamethasone Causes Hypertension in Rats Even Under Chemical Blockade of Peripheral Sympathetic Nerves. Frontiers in Neuroscience. 13: 1305. PMID 31866814 DOI: 10.3389/Fnins.2019.01305  0.32
2019 Smith BJ, Miller RA, Ericsson AC, Harrison DC, Strong R, Schmidt TM. Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice. Bmc Microbiology. 19: 130. PMID 31195972 DOI: 10.1186/S12866-019-1494-7  0.334
2019 Miller RA, Harrison DE, Astle CM, Bogue MA, Brind J, Fernandez E, Flurkey K, Javors M, Ladiges W, Leeuwenburgh C, Macchiarini F, Nelson J, Ryazanov AG, Snyder J, Stearns TM, ... ... Strong R, et al. Glycine supplementation extends lifespan of male and female mice. Aging Cell. e12953. PMID 30916479 DOI: 10.1111/Acel.12953  0.341
2017 Bai X, Wey MC, Martinez PA, Shi C, Fernandez E, Strong R. Neurochemical and motor changes in mice with combined mutations linked to Parkinson's disease. Pathobiology of Aging & Age Related Diseases. 7: 1267855. PMID 28326165 DOI: 10.1080/20010001.2017.1267855  0.776
2016 Soto-Pina AE, Franklin C, Rani CS, Gottlieb H, Hinojosa-Laborde C, Strong R. A novel model of dexamethasone-induced hypertension: use in investigating the role of tyrosine hydroxylase. The Journal of Pharmacology and Experimental Therapeutics. PMID 27405316 DOI: 10.1124/Jpet.116.234005  0.365
2016 Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Marinez PA, McCord JM, Miller BF, et al. Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell. PMID 27312235 DOI: 10.1111/Acel.12496  0.304
2015 Bai X, Wey MC, Fernandez E, Hart MJ, Gelfond J, Bokov AF, Rani S, Strong R. Rapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathy. Pathobiology of Aging & Age Related Diseases. 5: 28743. PMID 26306821  0.766
2014 Rodriguez KA, Dodds SG, Strong R, Galvan V, Sharp ZD, Buffenstein R. Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice. Frontiers in Molecular Neuroscience. 7: 83. PMID 25414638 DOI: 10.3389/Fnmol.2014.00083  0.316
2014 Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, Javors MA, Li X, Nadon NL, Nelson JF, Pletcher S, Salmon AB, Sharp ZD, Van Roekel S, Winkleman L, ... Strong R, et al. Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell. 13: 468-77. PMID 24341993 DOI: 10.1111/Acel.12194  0.348
2014 Hasty P, Livi CB, Dodds SG, Jones D, Strong R, Javors M, Fischer KE, Sloane L, Murthy K, Hubbard G, Sun L, Hurez V, Curiel TJ, Sharp ZD. eRapa restores a normal life span in a FAP mouse model. Cancer Prevention Research (Philadelphia, Pa.). 7: 169-78. PMID 24282255 DOI: 10.1158/1940-6207.Capr-13-0299  0.353
2013 Li X, Redus L, Chen C, Martinez PA, Strong R, Li S, O'Connor JC. Cognitive dysfunction precedes the onset of motor symptoms in the MitoPark mouse model of Parkinson's disease. Plos One. 8: e71341. PMID 23977020 DOI: 10.1371/Journal.Pone.0071341  0.364
2013 Goldstein DS, Sullivan P, Holmes C, Miller GW, Alter S, Strong R, Mash DC, Kopin IJ, Sharabi Y. Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease. Journal of Neurochemistry. 126: 591-603. PMID 23786406 DOI: 10.1111/Jnc.12345  0.35
2013 Flynn JM, O'Leary MN, Zambataro CA, Academia EC, Presley MP, Garrett BJ, Zykovich A, Mooney SD, Strong R, Rosen CJ, Kapahi P, Nelson MD, Kennedy BK, Melov S. Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell. 12: 851-62. PMID 23734717 DOI: 10.1111/Acel.12109  0.327
2013 Sheela Rani CS, Soto-Pina A, Iacovitti L, Strong R. Evolutionary conservation of an atypical glucocorticoid-responsive element in the human tyrosine hydroxylase gene. Journal of Neurochemistry. 126: 19-28. PMID 23647419 DOI: 10.1111/Jnc.12294  0.402
2013 Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, et al. Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 6-16. PMID 22451473 DOI: 10.1093/Gerona/Gls070  0.304
2012 Ramos FJ, Chen SC, Garelick MG, Dai DF, Liao CY, Schreiber KH, MacKay VL, An EH, Strong R, Ladiges WC, Rabinovitch PS, Kaeberlein M, Kennedy BK. Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Science Translational Medicine. 4: 144ra103. PMID 22837538 DOI: 10.1126/Scitranslmed.3003802  0.307
2012 Halloran J, Hussong SA, Burbank R, Podlutskaya N, Fischer KE, Sloane LB, Austad SN, Strong R, Richardson A, Hart MJ, Galvan V. Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice. Neuroscience. 223: 102-13. PMID 22750207 DOI: 10.1016/J.Neuroscience.2012.06.054  0.354
2012 Wilkinson JE, Burmeister L, Brooks SV, Chan CC, Friedline S, Harrison DE, Hejtmancik JF, Nadon N, Strong R, Wood LK, Woodward MA, Miller RA. Rapamycin slows aging in mice. Aging Cell. 11: 675-82. PMID 22587563 DOI: 10.1111/J.1474-9726.2012.00832.X  0.351
2012 Wey MC, Fernandez E, Martinez PA, Sullivan P, Goldstein DS, Strong R. Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease. Plos One. 7: e31522. PMID 22384032 DOI: 10.1371/Journal.Pone.0031522  0.762
2012 Majumder S, Caccamo A, Medina DX, Benavides AD, Javors MA, Kraig E, Strong R, Richardson A, Oddo S. Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling. Aging Cell. 11: 326-35. PMID 22212527 DOI: 10.1111/J.1474-9726.2011.00791.X  0.314
2011 Green MK, Rani CS, Joshi A, Soto-Piña AE, Martinez PA, Frazer A, Strong R, Morilak DA. Prenatal stress induces long term stress vulnerability, compromising stress response systems in the brain and impairing extinction of conditioned fear after adult stress. Neuroscience. 192: 438-51. PMID 21723377 DOI: 10.1016/J.Neuroscience.2011.06.041  0.305
2011 Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, De Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, ... ... Strong R, et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice Journals of Gerontology - Series a Biological Sciences and Medical Sciences. 66: 191-201. PMID 20974732 DOI: 10.1093/Gerona/Glq178  0.334
2011 Bai X, Wey MC, Martinez A, Bergmen P, Martinez V, Fernandez E, Strong R. Simultaneous Deletion of Endogenous Gpx1 and Aldh1a1 Genes Results in Motor Deficits in Young Adult Mice Free Radical Biology and Medicine. 51: S68. DOI: 10.1016/J.Freeradbiomed.2011.10.176  0.756
2010 Khodr CE, Clark S, Bokov AF, Richardson A, Strong R, Hurley DL, Phelps CJ. Early postnatal administration of growth hormone increases tuberoinfundibular dopaminergic neuron numbers in Ames dwarf mice. Endocrinology. 151: 3277-85. PMID 20463054 DOI: 10.1210/En.2009-1482  0.315
2010 Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-β levels in a mouse model of alzheimer's disease Plos One. 5. PMID 20376313 DOI: 10.1371/Journal.Pone.0009979  0.309
2009 Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 460: 392-5. PMID 19587680 DOI: 10.1038/Nature08221  0.35
2009 Price DA, Martinez AA, Seillier A, Koek W, Acosta Y, Fernandez E, Strong R, Lutz B, Marsicano G, Roberts JL, Giuffrida A. WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. The European Journal of Neuroscience. 29: 2177-86. PMID 19490092 DOI: 10.1111/J.1460-9568.2009.06764.X  0.366
2009 Rani CS, Elango N, Wang SS, Kobayashi K, Strong R. Identification of an activator protein-1-like sequence as the glucocorticoid response element in the rat tyrosine hydroxylase gene. Molecular Pharmacology. 75: 589-98. PMID 19060113 DOI: 10.1124/Mol.108.051219  0.42
2008 Strong R, Miller RA, Astle CM, Floyd RA, Flurkey K, Hensley KL, Javors MA, Leeuwenburgh C, Nelson JF, Ongini E, Nadon NL, Warner HR, Harrison DE. Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell. 7: 641-50. PMID 18631321 DOI: 10.1111/J.1474-9726.2008.00414.X  0.328
2007 McCarter R, Mejia W, Ikeno Y, Monnier V, Kewitt K, Gibbs M, McMahan A, Strong R. Plasma glucose and the action of calorie restriction on aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 62: 1059-70. PMID 17921417 DOI: 10.1093/Gerona/62.10.1059  0.325
2006 Fernandez E, Koek W, Ran Q, Gerhardt GA, France CP, Strong R. Monoamine metabolism and behavioral responses to ethanol in mitochondrial aldehyde dehydrogenase knockout mice. Alcoholism, Clinical and Experimental Research. 30: 1650-8. PMID 17010132 DOI: 10.1111/J.1530-0277.2006.00200.X  0.327
2006 Muller FL, Song W, Liu Y, Chaudhuri A, Pieke-Dahl S, Strong R, Huang TT, Epstein CJ, Roberts LJ, Csete M, Faulkner JA, Van Remmen H. Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy. Free Radical Biology & Medicine. 40: 1993-2004. PMID 16716900 DOI: 10.1016/J.Freeradbiomed.2006.01.036  0.301
2004 Van Remmen H, Qi W, Sabia M, Freeman G, Estlack L, Yang H, Mao Guo Z, Huang TT, Strong R, Lee S, Epstein CJ, Richardson A. Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radical Biology & Medicine. 36: 1625-34. PMID 15182862 DOI: 10.1016/J.Freeradbiomed.2004.03.016  0.338
2003 Liang H, Masoro EJ, Nelson JF, Strong R, McMahan CA, Richardson A. Genetic mouse models of extended lifespan. Experimental Gerontology. 38: 1353-64. PMID 14698816 DOI: 10.1016/J.Exger.2003.10.019  0.346
2003 Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe SR, Alderson NL, Baynes JW, Epstein CJ, Huang TT, Nelson J, Strong R, Richardson A. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiological Genomics. 16: 29-37. PMID 14679299 DOI: 10.1152/Physiolgenomics.00122.2003  0.358
2003 Strong R, Reddy V, Morley JE. Cholinergic deficits in the septal-hippocampal pathway of the SAM-P/8 senescence accelerated mouse. Brain Research. 966: 150-6. PMID 12646318 DOI: 10.1016/S0006-8993(02)04192-6  0.322
2002 Corbitt J, Hagerty T, Fernandez E, Morgan WW, Strong R. Transcriptional and post-transcriptional regulation of tyrosine hydroxylase messenger RNA in PC12 cells during persistent stimulation by VIP and PACAP38: differential regulation by protein kinase A and protein kinase C-dependent pathways. Neuropeptides. 36: 34-45. PMID 12147212 DOI: 10.1054/Npep.2002.0885  0.698
2002 Dong LQ, Ramos FJ, Wick MJ, Lim MA, Guo Z, Strong R, Richardson A, Liu F. Cloning and characterization of a testis and brain-specific isoform of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1 beta. Biochemical and Biophysical Research Communications. 294: 136-44. PMID 12054753 DOI: 10.1016/S0006-291X(02)00449-7  0.34
2002 Corbitt J, Vivekananda J, Wang SS, Strong R. Transcriptional and posttranscriptional control of tyrosine hydroxylase gene expression during persistent stimulation of pituitary adenylate cyclase-activating polypeptide receptors on PC12 cells: regulation by protein kinase A-dependent and protein kinase A-independent pathways. Journal of Neurochemistry. 71: 478-486. PMID 9681437 DOI: 10.1046/J.1471-4159.1998.71020478.X  0.789
2001 Hagerty T, Fernandez E, Lynch K, Wang SS, Morgan WW, Strong R. Interaction of a glucocorticoid-responsive element with regulatory sequences in the promoter region of the mouse tyrosine hydroxylase gene. Journal of Neurochemistry. 78: 1379-88. PMID 11579146 DOI: 10.1046/J.1471-4159.2001.00521.X  0.764
2001 Foster D, Strong R, Morgan WW. A tetracycline-repressible transactivator approach suggests a shorter half-life for tyrosine hydroxylase mRNA. Brain Research. Brain Research Protocols. 7: 137-46. PMID 11356380 DOI: 10.1016/S1385-299X(01)00056-3  0.45
2001 Hagerty T, Morgan WW, Elango N, Strong R. Identification of a glucocorticoid-responsive element in the promoter region of the mouse tyrosine hydroxylase gene. Journal of Neurochemistry. 76: 825-34. PMID 11158254 DOI: 10.1046/J.1471-4159.2001.00072.X  0.752
2000 Sands SA, Strong R, Corbitt J, Morilak DA. Effects of acute restraint stress on tyrosine hydroxylase mRNA expression in locus coeruleus of Wistar and Wistar-Kyoto rats Molecular Brain Research. 75: 1-7. PMID 10648882 DOI: 10.1016/S0169-328X(99)00255-7  0.744
1995 Mattammal MB, Haring JH, Chung HD, Raghu G, Strong R. An endogenous dopaminergic neurotoxin: implication for Parkinson's disease. Neurodegeneration. 4: 271-281. PMID 8581559 DOI: 10.1016/1055-8330(95)90016-0  0.321
1993 Wessels-Reiker M, Basiboina R, Howlett AC, Strong R. Vasoactive intestinal polypeptide-related peptides modulate tyrosine hydroxylase gene expression in PC12 cells through multiple adenylate cyclase-coupled receptors. Journal of Neurochemistry. 60: 1018-29. PMID 8094740 DOI: 10.1111/J.1471-4159.1993.Tb03250.X  0.44
1993 Heydari AR, Wu B, Takahashi R, Strong R, Richardson A. Expression of heat shock protein 70 is altered by age and diet at the level of transcription. Molecular and Cellular Biology. 13: 2909-18. PMID 7682654 DOI: 10.1128/mcb.13.5.2909-2918.1993  0.303
1992 Tümer N, Hale C, Lawler J, Strong R. Modulation of tyrosine hydroxylase gene expression in the rat adrenal gland by exercise: effects of age. Molecular Brain Research. 14: 51-56. PMID 1353855 DOI: 10.1016/0169-328X(92)90009-Z  0.358
1990 Strong R, Hale C, Moore MA, Wessels-Reiker M, Armbrecht HJ, Richardson A. GABA receptor modulation of tyrosine hydroxylase gene expression in the rat adrenal gland. Neuroscience Letters. 117: 175-180. PMID 1981253 DOI: 10.1016/0304-3940(90)90140-5  0.359
1990 Strong R, Moore MA, Hale C, Wessels-Reiker M, Armbrecht HJ, Richardson A. Modulation of tyrosine hydroxylase gene expression in the rat adrenal gland by age and reserpine Brain Research. 525: 126-132. PMID 1978789 DOI: 10.1016/0006-8993(90)91327-D  0.472
1987 Strong R. Regionally selective manifestations of neostriatal aging Annals of the New York Academy of Sciences. 515: 161-177. PMID 2966603 DOI: 10.1111/J.1749-6632.1988.Tb32980.X  0.317
1987 Sun GY, Huang H-, Lee D-, Chung-Wang Y-, Wood WG, Strong R, Sun AY. Chronic ethanol effect on the acidic phospholipids of synaptosomes isolated from cerebral cortex of C57BL/6NNIA mice--a comparison with age. Alcohol and Alcoholism. 22: 367-373. DOI: 10.1093/Oxfordjournals.Alcalc.A044725  0.309
1986 Strong R, Rehwaldt C, Wood WG. Intra-regional variations in the effect of aging on high affinity choline uptake, choline acetyltransferase and muscarinic cholinergic receptors in rat neostriatum. Experimental Gerontology. 21: 177-186. PMID 3803469 DOI: 10.1016/0531-5565(86)90071-9  0.315
1984 Strong R, Waymire JC, Samorajski T, Gottesfeld Z. Regional analysis of neostriatal cholinergic and dopaminergic receptor binding and tyrosine hydroxylase activity as a function of aging. Neurochemical Research. 9: 1641-52. PMID 6151626 DOI: 10.1007/Bf00964597  0.363
1980 Strong R, Hicks P, Hsu L, Bartus RT, Enna SJ. Age-related alterations in the rodent brain cholinergic system and behavior. Neurobiology of Aging. 1: 59-63. PMID 7266736 DOI: 10.1016/0197-4580(80)90025-1  0.336
1980 Hicks P, Strong R, Schoolar JC, Samorajski T. Aging alters amphetamine-induced stereotyped gnawing and neostriatal elimination of amphetamine in mice. Life Sciences. 27: 715-22. PMID 7191038 DOI: 10.1016/0024-3205(80)90324-0  0.365
Low-probability matches (unlikely to be authored by this person)
2018 Brind J, Miller RA, Strong R, Harrison DE, Macchiarini F. Dietary Glycine Supplementation Extends Lifespan of Genetically Heterogeneous Mice The Faseb Journal. 32. DOI: 10.1096/Fasebj.2018.32.1_Supplement.533.112  0.3
2007 Miller RA, Harrison DE, Astle CM, Floyd RA, Flurkey K, Hensley KL, Javors MA, Leeuwenburgh C, Nelson JF, Ongini E, Nadon NL, Warner HR, Strong R. An Aging Interventions Testing Program: study design and interim report. Aging Cell. 6: 565-75. PMID 17578509 DOI: 10.1111/J.1474-9726.2007.00311.X  0.299
2005 Ikeno Y, Hubbard GB, Lee S, Richardson A, Strong R, Diaz V, Nelson JF. Housing density does not influence the longevity effect of calorie restriction. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 60: 1510-7. PMID 16424282 DOI: 10.1093/Gerona/60.12.1510  0.298
2019 Song C, Zhang J, Qi S, Liu Z, Zhang X, Zheng Y, Andersen JP, Zhang W, Strong R, Martinez PA, Musi N, Nie J, Shi Y. Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson's diseases. Aging Cell. e12941. PMID 30838774 DOI: 10.1111/Acel.12941  0.295
2009 Ladiges W, Van Remmen H, Strong R, Ikeno Y, Treuting P, Rabinovitch P, Richardson A. Lifespan extension in genetically modified mice. Aging Cell. 8: 346-52. PMID 19485964 DOI: 10.1111/J.1474-9726.2009.00491.X  0.294
2013 Bingham BC, Sheela Rani CS, Frazer A, Strong R, Morilak DA. Exogenous prenatal corticosterone exposure mimics the effects of prenatal stress on adult brain stress response systems and fear extinction behavior. Psychoneuroendocrinology. 38: 2746-57. PMID 23937971 DOI: 10.1016/J.Psyneuen.2013.07.003  0.29
2012 Roth MK, Bingham B, Shah A, Joshi A, Frazer A, Strong R, Morilak DA. Effects of chronic plus acute prolonged stress on measures of coping style, anxiety, and evoked HPA-axis reactivity. Neuropharmacology. 63: 1118-26. PMID 22842072 DOI: 10.1016/J.Neuropharm.2012.07.034  0.288
2015 Liu Y, Yang Y, Dong H, Cutler RG, Strong R, Mattson MP. Thidoredxin-2 overexpression fails to rescue chronic high calorie diet induced hippocampal dysfunction. Experimental Neurology. PMID 26476179 DOI: 10.1016/J.Expneurol.2015.10.002  0.287
2013 Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, Javors M, Shih YY, Muir E, Solano Fonseca R, Strong R, Richardson AG, Lechleiter JD, Fox PT, Galvan V. Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 1412-21. PMID 23801246 DOI: 10.1038/Jcbfm.2013.82  0.286
2006 Ran Q, Gu M, Van Remmen H, Strong R, Roberts JL, Richardson A. Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity. Journal of Neuroscience Research. 84: 202-8. PMID 16673405 DOI: 10.1002/Jnr.20868  0.285
1984 Wood WG, Strong R, Williamson LS, Wise RW. Changes in lipid composition of cortical synaptosomes from different age groups of mice Life Sciences. 35: 1947-1952. PMID 6493001 DOI: 10.1016/0024-3205(84)90475-2  0.284
2019 Harrison DE, Strong R, Alavez S, Astle CM, DiGiovanni J, Fernandez E, Flurkey K, Garratt M, Gelfond JAL, Javors MA, Levi M, Lithgow GJ, Macchiarini F, Nelson JF, Sukoff Rizzo SJ, et al. Acarbose improves health and lifespan in aging HET3 mice. Aging Cell. e12898. PMID 30688027 DOI: 10.1111/Acel.12898  0.284
1995 Mattammal MB, Strong R, Lakshmi VM, Chung HD, Stephenson AH. Prostaglandin H synthetase-mediated metabolism of dopamine: implication for Parkinson's disease. Journal of Neurochemistry. 64: 1645-54. PMID 7891092 DOI: 10.1046/J.1471-4159.1995.64041645.X  0.282
1986 Wood WG, Williamson LS, Rocco D, Strong R. Chronic ethanol consumption and aging: Changes in lipid composition of liver microsomes Experimental Gerontology. 21: 195-201. PMID 3803471 DOI: 10.1016/0531-5565(86)90073-2  0.282
1984 Schurr A, Rigor BM, Strong R, Gottesfeld Z. The cholinergic system in rat striatum during morphine tolerance and dependence. Life Sciences. 33: 2521-5. PMID 6685808 DOI: 10.1016/0024-3205(83)90161-3  0.281
2014 Harrison DE, Strong R, Allison DB, Ames BN, Astle CM, Atamna H, Fernandez E, Flurkey K, Javors MA, Nadon NL, Nelson JF, Pletcher S, Simpkins JW, Smith D, Wilkinson JE, et al. Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell. 13: 273-82. PMID 24245565 DOI: 10.1111/Acel.12170  0.28
1992 Strong R, Wakade A, Arimura A, Haycock J. Short- and long-term effects of PACAP in PC12 cells: Phosphorylation and induction of tyrosine hydroxylase Regulatory Peptides. 37: 332. DOI: 10.1016/0167-0115(92)90644-A  0.278
2020 Parihar M, Dodds SG, Hubbard G, Javors MA, Strong R, Hasty P, Sharp ZD. Rapamycin Extends Life Span in Apc Colon Cancer FAP Model. Clinical Colorectal Cancer. PMID 33132009 DOI: 10.1016/J.Clcc.2020.08.006  0.275
2012 Nelson JF, Strong R, Bokov A, Diaz V, Ward W. Probing the relationship between insulin sensitivity and longevity using genetically modified mice. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 1332-8. PMID 23089336 DOI: 10.1093/Gerona/Gls199  0.274
1984 Strong R, Samorajski T, Gottesfeld Z. High-affinity uptake of neurotransmitters in rat neostriatum: effects of aging. Journal of Neurochemistry. 43: 1766-8. PMID 6149271 DOI: 10.1111/J.1471-4159.1984.Tb06108.X  0.273
1991 Strong R, Huang JS, Huang SS, Chung HD, Hale C, Burke WJ. Degeneration of the cholinergic innervation of the locus ceruleus in Alzheimer's disease. Brain Research. 542: 23-28. PMID 2054656 DOI: 10.1016/0006-8993(91)90992-5  0.271
2011 Majumder S, Richardson A, Strong R, Oddo S. Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. Plos One. 6: e25416. PMID 21980451 DOI: 10.1371/Journal.Pone.0025416  0.269
2019 Cheng CJ, Gelfond JAL, Strong R, Nelson JF. Genetically heterogeneous mice exhibit a female survival advantage that is age- and site-specific: Results from a large multi-site study. Aging Cell. e12905. PMID 30801953 DOI: 10.1111/Acel.12905  0.268
1989 Armbrecht HJ, Boltz M, Strong R, Richardson A, Bruns ME, Christakos S. Expression of calbindin-D decreases with age in intestine and kidney. Endocrinology. 125: 2950-6. PMID 2583050 DOI: 10.1210/Endo-125-6-2950  0.267
1994 Mattammal MB, Strong R, White E, Hsu FF. Characterization of peroxidative oxidation products of dopamine by mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications. 658: 21-30. PMID 7952128 DOI: 10.1016/0378-4347(94)00222-3  0.264
1994 Burke WJ, Raghu G, Strong R. Taxol protects against calcium-mediated death of differentiated rat pheochromocytoma cells. Life Sciences. 55: 313-319. PMID 7934633 DOI: 10.1016/0024-3205(94)90074-4  0.264
2015 Franklin C, Fortepiani L, Nguyen T, Rangel Y, Strong R, Gottlieb HB. Renal responses produced by microinjection of the kappa opioid receptor agonist, U50-488H, into sites within the rat lamina terminalis. Pharmacology Research & Perspectives. 3: e00117. PMID 26038693 DOI: 10.1002/Prp2.117  0.263
1989 Weraarchakul N, Strong R, Wood WG, Richardson A. The effect of aging and dietary restriction on DNA repair Experimental Cell Research. 181: 197-204. PMID 2917602 DOI: 10.1016/0014-4827(89)90193-6  0.263
1985 Sutter MA, Wood WG, Williamson LS, Strong R, Pickham K, Richardson A. Comparison of the hepatic mixed function oxidase system of young, adult, and old non-human primates (Macaca nemestrina). Biochemical Pharmacology. 34: 2983-7. PMID 4026880 DOI: 10.1016/0006-2952(85)90025-5  0.262
1992 Wakade A, Guo X, Strong R, Arimura A, Haycock J. Pituitary adenylate cyclase-activating polypeptide (PACAP) as a neurotransmitter in rat adrenal medulla Regulatory Peptides. 37: 331. DOI: 10.1016/0167-0115(92)90643-9  0.26
2015 Halloran J, Hussong SA, Burbank R, Podlutskaya N, Fischer KE, Sloane LB, Austad SN, Strong R, Richardson A, Hart MJ, Galvan V. Corrigendum to Chronic inhibition of mTOR by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice [Neuroscience, 223, (2012), 102-113] DOI: 10.1016/j.neuroscience.2012.06.054 Neuroscience. 306: 151. DOI: 10.1016/J.Neuroscience.2015.08.028  0.259
2016 Dodds SG, Livi CB, Parihar M, Hsu HK, Benavides AD, Morris J, Javors M, Strong R, Christy B, Hasty P, Sharp ZD. Adaptations to chronic rapamycin in mice. Pathobiology of Aging & Age Related Diseases. 6: 31688. PMID 27237224  0.256
1988 Armbrecht HJ, Strong R, Boltz M, Rocco D, Wood WG, Richardson A. Modulation of age-related changes in serum 1,25-dihydroxyvitamin D and parathyroid hormone by dietary restriction of Fischer 344 rats. The Journal of Nutrition. 118: 1360-5. PMID 3193253 DOI: 10.1093/Jn/118.11.1360  0.256
1993 Mattammal MB, Chung HD, Strong R, Hsu FF. Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications. 614: 205-212. PMID 8314932 DOI: 10.1016/0378-4347(93)80310-Z  0.253
2015 Tardif S, Ross C, Bergman P, Fernandez E, Javors M, Salmon A, Spross J, Strong R, Richardson A. Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 70: 577-87. PMID 25038772 DOI: 10.1093/Gerona/Glu101  0.251
1986 Wood WG, Gorka C, Armbrecht HJ, Williamson LS, Strong R. Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice. Life Sciences. 39: 2089-2095. PMID 3023777 DOI: 10.1016/0024-3205(86)90360-7  0.249
2011 Frahm KA, Lumia AR, Fernandez E, Strong R, Roberts JL, McGinnis MY. Effects of anabolic androgenic steroids and social subjugation on behavior and neurochemistry in male rats. Pharmacology, Biochemistry, and Behavior. 97: 416-22. PMID 20932994 DOI: 10.1016/J.Pbb.2010.09.015  0.243
2008 Nadon NL, Strong R, Miller RA, Nelson J, Javors M, Sharp ZD, Peralba JM, Harrison DE. Design of aging intervention studies: The NIA interventions testing program Age. 30: 187-199. DOI: 10.1007/S11357-008-9048-1  0.241
2010 Caccamo A, Majumder S, Richardson A, Strong R, Oddo S. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. The Journal of Biological Chemistry. 285: 13107-20. PMID 20178983 DOI: 10.1074/Jbc.M110.100420  0.237
1992 Hazzard DG, Bronson RT, McClearn GE, Strong R. Selection of an appropriate animal model to study aging processes with special emphasis on the use of rat strains. Journal of Gerontology. 47: B63-4. PMID 1573179 DOI: 10.1093/Geronj/47.3.B63  0.236
2013 Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, Strong R, Bokov A, Javors MA, Ikeno Y, Hubbard G, Hasty P, Sharp ZD. Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors. Aging. 5: 100-10. PMID 23454836 DOI: 10.18632/AGING.100533  0.235
2016 Nadon NL, Strong R, Miller RA, Harrison DE. NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model. Ebiomedicine. PMID 27923560 DOI: 10.1016/J.Ebiom.2016.11.038  0.231
2022 Bou Sleiman M, Roy S, Gao AW, Sadler MC, von Alvensleben GVG, Li H, Sen S, Harrison DE, Nelson JF, Strong R, Miller RA, Kutalik Z, Williams RW, Auwerx J. Sex- and age-dependent genetics of longevity in a heterogeneous mouse population. Science (New York, N.Y.). 377: eabo3191. PMID 36173858 DOI: 10.1126/science.abo3191  0.223
2018 Lee HJ, Feliers D, Barnes JL, Oh S, Choudhury GG, Diaz V, Galvan V, Strong R, Nelson J, Salmon A, Kevil CG, Kasinath BS. Hydrogen sulfide ameliorates aging-associated changes in the kidney. Geroscience. PMID 29717417 DOI: 10.1007/s11357-018-0018-y  0.221
1987 Wood WG, Lahiri S, Gorka C, Armbrecht HJ, Strong R. In vitro effects of ethanol on erythrocyte membrane fluidity of alcoholic patients: an electron spin resonance study. Alcoholism: Clinical and Experimental Research. 11: 332-335. PMID 2820262 DOI: 10.1111/J.1530-0277.1987.Tb01320.X  0.221
1988 Strong R, Wood WG, Burke WJ. Central nervous system disorders of aging : clinical intervention and research Topics in Geriatric Rehabilitation. 3: 79. DOI: 10.1097/00013614-198807000-00009  0.213
1997 Elango N, Vivekananda J, Strong R, Katz MS. Nuclei isolation from bone cells for nuclear run-on assays. Biotechniques. 23: 422-4. PMID 9298210 DOI: 10.2144/97233Bm15  0.207
2022 Snyder JM, Casey KM, Galecki A, Harrison DE, Jayarathne H, Kumar N, Macchiarini F, Rosenthal N, Sadagurski M, Salmon AB, Strong R, Miller RA, Ladiges W. Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice. Geroscience. PMID 35974129 DOI: 10.1007/s11357-022-00641-0  0.207
1986 Wood WG, Gorka C, Williamson LS, Strong R, Sun AY, Sun GY, Schroeder F. Dolichol alters dynamic and static properties of mouse synaptosomal plasma membranes. Febs Letters. 205: 25-8. PMID 3017757 DOI: 10.1016/0014-5793(86)80858-4  0.205
2010 Sharp ZD, Strong R. The role of mTOR signaling in controlling mammalian life span: what a fungicide teaches us about longevity. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 65: 580-9. PMID 20083554 DOI: 10.1093/Gerona/Glp212  0.204
2022 Strong R, Miller RA, Cheng CJ, Nelson JF, Gelfond J, Allani SK, Diaz V, Dorigatti AO, Dorigatti J, Fernandez E, Galecki A, Ginsburg B, Hamilton KL, Javors MA, Kornfeld K, et al. Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice. Aging Cell. e13724. PMID 36179270 DOI: 10.1111/acel.13724  0.197
2021 Harrison DE, Strong R, Reifsnyder P, Kumar N, Fernandez E, Flurkey K, Javors MA, Lopez-Cruzan M, Macchiarini F, Nelson JF, Bitto A, Sindler AL, Cortopassi G, Kavanagh K, Leng L, et al. 17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex. Aging Cell. e13328. PMID 33788371 DOI: 10.1111/acel.13328  0.194
2020 Parihar M, Dodds SG, Javors M, Strong R, Hasty P, Sharp ZD. Sex-dependent lifespan extension of FAP mice by chronic mTOR inhibition. Aging Pathobiology and Therapeutics. 2: 187-194. PMID 33834178 DOI: 10.31491/apt.2020.12.039  0.193
2018 Weiss R, Fernandez E, Liu Y, Strong R, Salmon AB. Metformin reduces glucose intolerance caused by rapamycin treatment in genetically heterogeneous female mice. Aging. PMID 29579736 DOI: 10.18632/aging.101401  0.192
2020 Miller RA, Harrison DE, Allison DB, Bogue MA, Debarba LK, Diaz V, Fernandez E, Galecki AT, Garvey WT, Jayarathne H, Kumar N, Javors M, Ladiges W, Macchiarini F, Nelson JF, ... ... Strong R, et al. Canagliflozin extends lifespan in genetically heterogeneous male but not female mice. Jci Insight. PMID 32990681 DOI: 10.1172/jci.insight.140019  0.19
2013 Bai X, Fermandez E, Gould G, Strong R. Homozygous Deletion of Glutathione Peroxidase 1 and Aldehyde Dehydrogenase 1a1 Genes Is Not Associated with Schizophrenia-Like Behavior in Mice. Journal of Biochemical and Pharmacological Research. 1: 228-235. PMID 24494173  0.187
1988 Wood WG, Strong R. Geriatric Clinical Pharmacology Topics in Geriatric Rehabilitation. 3: 77. DOI: 10.1097/00013614-198807000-00007  0.186
2023 Yildirim G, Bergamo ETP, Poudel SB, Ruff RR, Dixit M, Hu B, Mijares DQ, Witek L, Chlebek C, Harrison DE, Strong R, Miller RA, Ladiges W, Bromage TG, Rosen CJ, et al. Long-term effects of canagliflozin treatment on the skeleton of aged UM-HET3 mice. Geroscience. PMID 37166526 DOI: 10.1007/s11357-023-00803-8  0.185
2023 Poudel SB, Ruff RR, Yildirim G, Miller RA, Harrison DE, Strong R, Kirsch T, Yakar S. Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice. Biorxiv : the Preprint Server For Biology. PMID 38168298 DOI: 10.1101/2023.12.16.571693  0.172
2014 Liu Y, Diaz V, Fernandez E, Strong R, Ye L, Baur JA, Lamming DW, Richardson A, Salmon AB. Rapamycin-induced metabolic defects are reversible in both lean and obese mice. Aging. 6: 742-54. PMID 25324470  0.17
2020 Strong R, Miller RA, Bogue M, Fernandez E, Javors MA, Libert S, Marinez PA, Murphy MP, Musi N, Nelson JF, Petrascheck M, Reifsnyder P, Richardson A, Salmon AB, Macchiarini F, et al. Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects. Aging Cell. e13269. PMID 33145977 DOI: 10.1111/acel.13269  0.165
2024 Poudel SB, Ruff RR, Yildirim G, Miller RA, Harrison DE, Strong R, Kirsch T, Yakar S. Development of primary osteoarthritis during aging in genetically diverse UM- HET3 mice. Research Square. PMID 38343826 DOI: 10.21203/rs.3.rs-3858256/v1  0.16
2023 Jiang N, Cheng CJ, Gelfond J, Strong R, Diaz V, Nelson JF. Prepubertal castration eliminates sex differences in lifespan and growth trajectories in genetically heterogeneous mice. Aging Cell. e13891. PMID 37221997 DOI: 10.1111/acel.13891  0.16
2023 Masato A, Plotegher N, Terrin F, Sandre M, Faustini G, Thor A, Adams S, Berti G, Cogo S, De Lazzari F, Fontana CM, Martinez PA, Strong R, Bandopadhyay R, Bisaglia M, et al. DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson's disease. Npj Parkinson's Disease. 9: 42. PMID 36966140 DOI: 10.1038/s41531-023-00485-1  0.157
2023 Harrison DE, Strong R, Reifsnyder P, Rosenthal N, Korstanje R, Fernandez E, Flurkey K, Ginsburg BC, Murrell MD, Javors MA, Lopez-Cruzan M, Nelson JF, Willcox BJ, Allsopp R, Watumull DM, et al. Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used. Geroscience. PMID 38041783 DOI: 10.1007/s11357-023-01011-0  0.156
2014 Bai X, Strong R. Expression of synaptophysin protein in different dopaminergic cell lines. Journal of Biochemical and Pharmacological Research. 2: 185-190. PMID 26279968  0.154
2023 Martinez PA, Martinez VE, Rani S, Murrell M, Javors M, Gelfond J, Doorn JA, Fernandez E, Strong R. Impaired aldehyde detoxification exacerbates motor deficits in an alpha-synuclein mouse model of Parkinson's disease. Brain and Behavior. e3150. PMID 37452461 DOI: 10.1002/brb3.3150  0.152
2023 Jiang N, Cheng CJ, Strong R, Nelson JF. Castration reduces mortality and increases resilience in male mice: what is next? Geroscience. PMID 37861928 DOI: 10.1007/s11357-023-00973-5  0.138
2015 Ross C, Salmon A, Strong R, Fernandez E, Javors M, Richardson A, Tardif S. Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus). Aging. PMID 26568298  0.136
2024 Miller RA, Harrison DE, Cortopassi GA, Dehghan I, Fernandez E, Garratt M, Geisler JG, Ginsburg BC, Han ML, Kaczorowski CC, Kumar N, Leiser SF, Lopez-Cruzan M, Milne G, Mitchell JR, ... ... Strong R, et al. Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin. Geroscience. PMID 38753230 DOI: 10.1007/s11357-024-01176-2  0.12
2020 Guderyon MJ, Chen C, Bhattacharjee A, Ge G, Fernandez RA, Gelfond JAL, Gorena KM, Cheng CJ, Li Y, Nelson JF, Strong RJ, Hornsby PJ, Clark RA, Li S. Mobilization-based transplantation of young-donor hematopoietic stem cells extends lifespan in mice. Aging Cell. e13110. PMID 32012439 DOI: 10.1111/acel.13110  0.118
2024 Jiang N, Gelfond J, Liu Q, Strong R, Nelson JF. The Gehan test identifies life-extending compounds overlooked by the log-rank test in the NIA Interventions Testing Program: Metformin, Enalapril, caffeic acid phenethyl ester, green tea extract, and 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride. Geroscience. PMID 38630424 DOI: 10.1007/s11357-024-01161-9  0.096
2024 Jiang N, Cheng CJ, Liu Q, Strong R, Gelfond J, Nelson JF. Deciphering the Timing and Impact of Life-extending Drugs: A Novel Analytic Approach that Differentiates Early, Midlife, and Senescence Phase Efficacies. Biorxiv : the Preprint Server For Biology. PMID 38586027 DOI: 10.1101/2024.03.27.585737  0.085
2021 Salmon AB, Nelson JF, Gelfond JAL, Javors M, Ginsburg B, Lopez-Cruzan M, Galvan V, Fernandez E, Musi N, Ikeno Y, Hubbard G, Lechleiter J, Hornsby PJ, Strong R. San Antonio Nathan Shock Center: your one-stop shop for aging research. Geroscience. PMID 34240333 DOI: 10.1007/s11357-021-00417-y  0.077
2023 Sharp ZD, Strong R. Rapamycin, the only drug that has been consistently demonstrated to increase mammalian longevity. An update. Experimental Gerontology. 176: 112166. PMID 37011714 DOI: 10.1016/j.exger.2023.112166  0.068
2021 Lee HJ, Feliers D, Barnes JL, Oh S, Choudhury GG, Diaz V, Galvan V, Strong R, Nelson J, Salmon A, Kevil CG, Kasinath BS. Correction to: Hydrogen sulfide ameliorates aging-associated changes in the kidney. Geroscience. PMID 33511489 DOI: 10.1007/s11357-021-00326-0  0.067
2021 Peterson AL, Young-McCaughan S, Roache JD, Mintz J, Litz BT, Williamson DE, Resick PA, Foa EB, McGeary DD, Dondanville KA, Taylor DJ, Wachen JS, Fox PT, Bryan CJ, McLean CP, ... ... Strong R, et al. STRONG STAR and the consortium to alleviate PTSD: Shaping the future of combat PTSD and related conditions in military and veteran populations. Contemporary Clinical Trials. 106583. PMID 34600107 DOI: 10.1016/j.cct.2021.106583  0.033
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