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Kenneth W. Kinzler - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Genetics, Molecular Biology
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324 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Mog BJ, Marcou N, DiNapoli SR, Pearlman AH, Nichakawade TD, Hwang MS, Douglass J, Hsiue EH, Glavaris S, Wright KM, Konig MF, Paul S, Wyhs N, Ge J, Miller MS, ... ... Kinzler KW, et al. Preclinical studies show that Co-STARs combine the advantages of chimeric antigen and T cell receptors for the treatment of tumors with low antigen densities. Science Translational Medicine. 16: eadg7123. PMID 38985855 DOI: 10.1126/scitranslmed.adg7123  0.65
2024 Nichakawade TD, Ge J, Mog BJ, Lee BS, Pearlman AH, Hwang MS, DiNapoli SR, Wyhs N, Marcou N, Glavaris S, Konig MF, Gabelli SB, Watson E, Sterling C, Wagner-Johnston N, ... ... Kinzler KW, et al. TRBC1-targeting antibody-drug conjugates for the treatment of T cell cancers. Nature. PMID 38538786 DOI: 10.1038/s41586-024-07233-2  0.657
2024 Douville C, Lahouel K, Kuo A, Grant H, Avigdor BE, Curtis SD, Summers M, Cohen JD, Wang Y, Mattox A, Dudley J, Dobbyn L, Popoli M, Ptak J, Nehme N, ... ... Kinzler KW, et al. Machine learning to detect the SINEs of cancer. Science Translational Medicine. 16: eadi3883. PMID 38266106 DOI: 10.1126/scitranslmed.adi3883  0.497
2023 Cook AL, Sur S, Dobbyn L, Watson E, Cohen JD, Ptak B, Lee BS, Paul S, Hsiue E, Popoli M, Vogelstein B, Papadopoulos N, Bettegowda C, Gabrielson K, Zhou S, ... Kinzler KW, et al. Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape. Biorxiv : the Preprint Server For Biology. PMID 38234817 DOI: 10.1101/2023.12.28.573594  0.547
2023 Wright KM, DiNapoli SR, Miller MS, Aitana Azurmendi P, Zhao X, Yu Z, Chakrabarti M, Shi W, Douglass J, Hwang MS, Hsiue EH, Mog BJ, Pearlman AH, Paul S, Konig MF, ... ... Kinzler KW, et al. Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen. Nature Communications. 14: 5063. PMID 37604828 DOI: 10.1038/s41467-023-40821-w  0.643
2023 Mattox AK, Douville C, Wang Y, Popoli M, Ptak J, Silliman N, Dobbyn L, Schaefer J, Lu S, Pearlman AH, Cohen JD, Tie J, Gibbs P, Lahouel K, Bettegowda C, ... ... Kinzler KW, et al. The origin of highly elevated cell-free DNA in healthy individuals and patients with pancreatic, colorectal, lung, or ovarian cancer. Cancer Discovery. PMID 37565753 DOI: 10.1158/2159-8290.CD-21-1252  0.51
2023 Douville C, Curtis S, Summers M, Azad TD, Rincon-Torroella J, Wang Y, Mattox A, Avigdor B, Dudley J, Materi J, Raj D, Nair S, Bhanja D, Tuohy K, Dobbyn L, ... ... Kinzler KW, et al. Seq-ing the SINEs of central nervous system tumors in cerebrospinal fluid. Cell Reports. Medicine. 4: 101148. PMID 37552989 DOI: 10.1016/j.xcrm.2023.101148  0.481
2023 Rincon-Torroella J, Molin MD, Mog B, Han G, Watson E, Wyhs N, Ishiyama S, Ahmedna T, Minn I, Azad NS, Bettegowda C, Papadopoulos N, Kinzler KW, Zhou S, Vogelstein B, et al. ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1. Biorxiv : the Preprint Server For Biology. PMID 37546808 DOI: 10.1101/2023.07.23.550207  0.476
2023 Wang Y, Douville C, Cohen JD, Mattox A, Curtis S, Silliman N, Popoli M, Ptak J, Dobbyn L, Nehme N, Dudley JC, Summers M, Zhang M, Ho-Pham LT, Tran BNH, ... ... Kinzler KW, et al. Detection of rare mutations, copy number alterations, and methylation in the same template DNA molecules. Proceedings of the National Academy of Sciences of the United States of America. 120: e2220704120. PMID 37014860 DOI: 10.1073/pnas.2220704120  0.489
2023 Lu S, Mattox AK, Aitana Azurmendi P, Christodoulou I, Wright KM, Popoli M, Chen Z, Sur S, Li Y, Bonifant CL, Bettegowda C, Papadopoulos N, Zhou S, Gabelli SB, Vogelstein B, ... Kinzler KW, et al. The rapid and highly parallel identification of antibodies with defined biological activities by SLISY. Nature Communications. 14: 17. PMID 36596784 DOI: 10.1038/s41467-022-35668-6  0.643
2022 Cook AL, Wyhs N, Sur S, Ptak B, Popoli M, Dobbyn L, Papadopoulos T, Bettegowda C, Papadopoulos N, Vogelstein B, Zhou S, Kinzler KW. An isogenic cell line panel for sequence-based screening of targeted anticancer drugs. Iscience. 25: 104437. PMID 35692635 DOI: 10.1016/j.isci.2022.104437  0.478
2022 Sengupta S, Board NL, Wu F, Moskovljevic M, Douglass J, Zhang J, Reinhold BR, Duke-Cohan J, Yu J, Reed MC, Tabdili Y, Azurmendi A, Fray EJ, Zhang H, Hsiue EH, ... ... Kinzler KW, et al. TCR-mimic bispecific antibodies to target the HIV-1 reservoir. Proceedings of the National Academy of Sciences of the United States of America. 119: e2123406119. PMID 35394875 DOI: 10.1073/pnas.2123406119  0.517
2022 Pearlman AH, Hwang MS, Konig MF, Hsiue EH, Douglass J, DiNapoli SR, Mog BJ, Bettegowda C, Pardoll DM, Gabelli SB, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S. Author Correction: Targeting public neoantigens for cancer immunotherapy. Nature Cancer. 2: 865-867. PMID 35122030 DOI: 10.1038/s43018-021-00246-0  0.652
2021 Pearlman AH, Hwang MS, Konig MF, Hsiue EH, Douglass J, DiNapoli SR, Mog BJ, Bettegowda C, Pardoll DM, Gabelli SB, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S. Targeting public neoantigens for cancer immunotherapy. Nature Cancer. 2: 487-497. PMID 34676374 DOI: 10.1038/s43018-021-00210-y  0.695
2021 Hwang MS, Miller MS, Thirawatananond P, Douglass J, Wright KM, Hsiue EH, Mog BJ, Aytenfisu TY, Murphy MB, Aitana Azurmendi P, Skora AD, Pearlman AH, Paul S, DiNapoli SR, Konig MF, ... ... Kinzler KW, et al. Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens. Nature Communications. 12: 5271. PMID 34489470 DOI: 10.1038/s41467-021-25605-4  0.682
2021 Naidoo J, Schreck KC, Fu W, Hu C, Carvajal-Gonzalez A, Connolly RM, Santa-Maria CA, Lipson EJ, Holdhoff M, Forde PM, Douville C, Riemer J, Barnes A, Redmond KJ, Kleinberg L, ... ... Kinzler KW, et al. Pembrolizumab for patients with leptomeningeal metastasis from solid tumors: efficacy, safety, and cerebrospinal fluid biomarkers. Journal For Immunotherapy of Cancer. 9. PMID 34380662 DOI: 10.1136/jitc-2021-002473  0.439
2021 Rose L, Graham L, Koenecke A, Powell M, Xiong R, Shen Z, Mench B, Kinzler KW, Bettegowda C, Vogelstein B, Athey S, Vogelstein JT, Konig MF, Wagner TH. The Association Between Alpha-1 Adrenergic Receptor Antagonists and In-Hospital Mortality From COVID-19. Frontiers in Medicine. 8: 637647. PMID 33869251 DOI: 10.3389/fmed.2021.637647  0.374
2021 Hwang MS, Mog BJ, Douglass J, Pearlman AH, Hsiue EH, Paul S, DiNapoli SR, Konig MF, Pardoll DM, Gabelli SB, Bettegowda C, Papadopoulos N, Vogelstein B, Zhou S, Kinzler KW. Targeting loss of heterozygosity for cancer-specific immunotherapy. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33731480 DOI: 10.1073/pnas.2022410118  0.691
2021 Paul S, Pearlman AH, Douglass J, Mog BJ, Hsiue EH, Hwang MS, DiNapoli SR, Konig MF, Brown PA, Wright KM, Sur S, Gabelli SB, Li Y, Ghiaur G, Pardoll D, ... ... Kinzler KW, et al. TCR beta chain-directed bispecific antibodies for the treatment of T-cell cancers. Science Translational Medicine. PMID 33649188 DOI: 10.1126/scitranslmed.abd3595  0.662
2021 Hsiue EH, Wright KM, Douglass J, Hwang MS, Mog BJ, Pearlman AH, Paul S, DiNapoli SR, Konig MF, Wang Q, Schaefer A, Miller MS, Skora AD, Azurmendi PA, Murphy MB, ... ... Kinzler KW, et al. Targeting a neoantigen derived from a common mutation. Science (New York, N.Y.). PMID 33649166 DOI: 10.1126/science.abc8697  0.726
2021 Douglass J, Hsiue EH, Mog BJ, Hwang MS, DiNapoli SR, Pearlman AH, Miller MS, Wright KM, Azurmendi PA, Wang Q, Paul S, Schaefer A, Skora AD, Molin MD, Konig MF, ... ... Kinzler KW, et al. Bispecific antibodies targeting mutant neoantigens. Science Immunology. 6. PMID 33649101 DOI: 10.1126/sciimmunol.abd5515  0.681
2021 Douville C, Moinova HR, Thota PN, Shaheen NJ, Iyer PG, Canto MI, Wang JS, Dumot J, Faulx A, Kinzler KW, Papadopoulos N, Vogelstein B, Markowitz SD, Bettegowda C, Willis JE, et al. Massively Parallel Sequencing of Esophageal Brushings Enables an Aneuploidy-Based Classification of Patients with Barrett's Esophagus. Gastroenterology. PMID 33493502 DOI: 10.1053/j.gastro.2021.01.209  0.443
2020 Rose L, Graham L, Koenecke A, Powell M, Xiong R, Shen Z, Kinzler KW, Bettegowda C, Vogelstein B, Konig MF, Athey S, Vogelstein JT, Wagner TH. The Association Between Alpha-1 Adrenergic Receptor Antagonists and In-Hospital Mortality from COVID-19. Medrxiv : the Preprint Server For Health Sciences. PMID 33398294 DOI: 10.1101/2020.12.18.20248346  0.372
2020 Vogelstein JT, Powell M, Koenecke A, Xiong R, Fischer N, Huq S, Khalafallah AM, Caffo B, Stuart EA, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S, Bettegowda C, Konig MF, et al. Alpha-1 adrenergic receptor antagonists for preventing acute respiratory distress syndrome and death from cytokine storm syndrome. Arxiv. PMID 32550250  0.377
2020 Konig MF, Powell MA, Staedtke V, Bai RY, Thomas DL, Fischer NM, Huq S, Khalafallah AM, Koenecke A, Xiong R, Mensh B, Papadopoulos N, Kinzler KW, Vogelstein B, Vogelstein JT, et al. Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists. The Journal of Clinical Investigation. PMID 32352407 DOI: 10.1172/Jci139642  0.445
2020 Lennon AM, Buchanan AH, Kinde I, Warren A, Honushefsky A, Cohain AT, Ledbetter DH, Sanfilippo F, Sheridan K, Rosica D, Adonizio CS, Hwang HJ, Lahouel K, Cohen JD, Douville C, ... ... Kinzler KW, et al. Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention. Science (New York, N.Y.). PMID 32345712 DOI: 10.1126/Science.Abb9601  0.441
2020 Douville C, Cohen JD, Ptak J, Popoli M, Schaefer J, Silliman N, Dobbyn L, Schoen RE, Tie J, Gibbs P, Goggins M, Wolfgang CL, Wang TL, Shih IM, Karchin R, ... ... Kinzler KW, et al. Assessing aneuploidy with repetitive element sequencing. Proceedings of the National Academy of Sciences of the United States of America. PMID 32075918 DOI: 10.1073/Pnas.1910041117  0.474
2019 Lahouel K, Younes L, Danilova L, Giardiello FM, Hruban RH, Groopman J, Kinzler KW, Vogelstein B, Geman D, Tomasetti C. Revisiting the tumorigenesis timeline with a data-driven generative model. Proceedings of the National Academy of Sciences of the United States of America. PMID 31882448 DOI: 10.1073/Pnas.1914589117  0.443
2019 Miller MS, Douglass J, Hwang MS, Skora AD, Murphy M, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S, Gabelli SB. An engineered antibody fragment targeting mutant β-catenin via Major Histocompatibility Complex I neoantigen presentation. The Journal of Biological Chemistry. PMID 31690625 DOI: 10.1074/Jbc.Ra119.010251  0.595
2019 Wang Q, Douglass J, Hwang MS, Hsiue EH, Mog BJ, Zhang M, Papadopoulos N, Kinzler KW, Zhou S, Vogelstein B. Direct Detection and Quantification of Neo-antigens. Cancer Immunology Research. PMID 31527070 DOI: 10.1158/2326-6066.Cir-19-0107  0.33
2019 Rodriguez Pena MDC, Springer SU, Taheri D, Li L, Tregnago AC, Eich ML, Eltoum IA, VandenBussche CJ, Papadopoulos N, Kinzler KW, Vogelstein B, Netto GJ. Performance of novel non-invasive urine assay UroSEEK in cohorts of equivocal urine cytology. Virchows Archiv : An International Journal of Pathology. PMID 31482302 DOI: 10.1007/S00428-019-02654-1  0.325
2019 Mattox AK, Bettegowda C, Zhou S, Papadopoulos N, Kinzler KW, Vogelstein B. Applications of liquid biopsies for cancer. Science Translational Medicine. 11. PMID 31462507 DOI: 10.1126/Scitranslmed.Aay1984  0.517
2019 Reiter JG, Baretti M, Gerold JM, Makohon-Moore AP, Daud A, Iacobuzio-Donahue CA, Azad NS, Kinzler KW, Nowak MA, Vogelstein B. An analysis of genetic heterogeneity in untreated cancers. Nature Reviews. Cancer. PMID 31455892 DOI: 10.1038/S41568-019-0185-X  0.305
2019 Lee B, Lipton L, Cohen J, Tie J, Javed AA, Li L, Goldstein D, Burge M, Cooray P, Nagrial A, Tebbutt NC, Thomson B, Nikfarjam M, Harris M, Haydon A, ... ... Kinzler KW, et al. Circulating tumor DNA as a potential marker of adjuvant chemotherapy benefit following surgery for localised pancreatic cancer. Annals of Oncology : Official Journal of the European Society For Medical Oncology. PMID 31250894 DOI: 10.1093/Annonc/Mdz200  0.336
2019 Eich ML, Rodriguez Pena MDC, Springer SU, Taheri D, Tregnago AC, Salles DC, Bezerra SM, Cunha IW, Fujita K, Ertoy D, Bivalacqua TJ, Tomasetti C, Papadopoulos N, Kinzler KW, Vogelstein B, et al. Incidence and distribution of UroSEEK gene panel in a multi-institutional cohort of bladder urothelial carcinoma. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. PMID 31028363 DOI: 10.1038/S41379-019-0276-Y  0.411
2019 Smith KN, Llosa NJ, Cottrell TR, Siegel N, Fan H, Suri P, Chan HY, Guo H, Oke T, Awan AH, Verde F, Danilova L, Anagnostou V, Tam AJ, Luber BS, ... ... Kinzler KW, et al. Correction to: persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1 (Journal for Immuno Therapy of Cancer (2019) 7 (40) DOI: 10.1186/s40425-018-0492-x) Journal For Immunotherapy of Cancer. 7: 7. PMID 30841906 DOI: 10.1186/S40425_019_0547_7  0.304
2019 Smith KN, Llosa NJ, Cottrell TR, Siegel N, Fan H, Suri P, Chan HY, Guo H, Oke T, Awan AH, Verde F, Danilova L, Anagnostou V, Tam AJ, Luber BS, ... ... Kinzler KW, et al. Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1. Journal For Immunotherapy of Cancer. 7: 40. PMID 30744692 DOI: 10.1186/S40425-018-0492-X  0.34
2019 Wong R, Tie J, Lee M, Cohen J, Wang Y, Li L, Ma S, Christie M, Kosmider S, Tomasetti C, Papadopoulos N, Kinzler K, Vogelstein B, Gibbs P. The potential role of circulating tumor DNA (ctDNA) in the further investigation of colorectal cancer patients with non-specific findings on standard investigations. International Journal of Cancer. PMID 30628066 DOI: 10.1002/Ijc.32117  0.335
2018 Gallia GL, Zhang M, Ning Y, Haffner MC, Batista D, Binder ZA, Bishop JA, Hann CL, Hruban RH, Ishii M, Klein AP, Reh DD, Rooper LM, Salmasi V, Tamargo RJ, ... ... Kinzler KW, et al. Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma. Nature Communications. 9: 5410. PMID 30575736 DOI: 10.1038/S41467-018-07578-Z  0.567
2018 Wu RC, Wang P, Lin SF, Zhang M, Song Q, Chu T, Wang BG, Kurman RJ, Vang R, Kinzler K, Tomasetti C, Jiao Y, Shih IM, Wang TL. Genomic landscape and evolutionary trajectories of ovarian cancer early precursor lesions. The Journal of Pathology. PMID 30560554 DOI: 10.1002/Path.5219  0.302
2018 Palsgrove DN, Taheri D, Springer SU, Cowan M, Guner G, Mendoza Rodriguez MA, Del Carmen Rodriguez Pena M, Wang Y, Kinde I, Ricardo BFP, Cunha I, Fujita K, Ertoy D, Kinzler KW, Bivalacqua TJ, et al. Targeted sequencing of Plasmacytoid urothelial carcinoma reveals frequent TERT promoter mutations. Human Pathology. PMID 30447301 DOI: 10.1016/J.Humpath.2018.10.033  0.428
2018 Springer SU, Chen CH, Rodriguez Pena MDC, Li L, Douville C, Wang Y, Cohen JD, Taheri D, Silliman N, Schaefer J, Ptak J, Dobbyn L, Papoli M, Kinde I, Afsari B, ... ... Kinzler KW, et al. Correction: Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy. Elife. 7. PMID 30418154 DOI: 10.7554/Elife.43237  0.413
2018 Reiter JG, Makohon-Moore AP, Gerold JM, Heyde A, Attiyeh MA, Kohutek ZA, Tokheim CJ, Brown A, DeBlasio RM, Niyazov J, Zucker A, Karchin R, Kinzler KW, Iacobuzio-Donahue CA, Vogelstein B, et al. Minimal functional driver gene heterogeneity among untreated metastases. Science (New York, N.Y.). 361: 1033-1037. PMID 30190408 DOI: 10.1126/Science.Aat7171  0.35
2018 Wang Y, Li L, Douville C, Cohen JD, Yen TT, Kinde I, Sundfelt K, Kjær SK, Hruban RH, Shih IM, Wang TL, Kurman RJ, Springer S, Ptak J, Popoli M, ... ... Kinzler KW, et al. Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers. Science Translational Medicine. 10. PMID 29563323 DOI: 10.1126/Scitranslmed.Aap8793  0.371
2018 Springer SU, Chen CH, Rodriguez Pena MDC, Li L, Douville C, Wang Y, Cohen JD, Taheri D, Silliman N, Schaefer J, Ptak J, Dobbyn L, Papoli M, Kinde I, Afsari B, ... ... Kinzler KW, et al. Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy. Elife. 7. PMID 29557778 DOI: 10.7554/Elife.32143  0.419
2018 Douville C, Springer S, Kinde I, Cohen JD, Hruban RH, Lennon AM, Papadopoulos N, Kinzler KW, Vogelstein B, Karchin R. Detection of aneuploidy in patients with cancer through amplification of long interspersed nucleotide elements (LINEs). Proceedings of the National Academy of Sciences of the United States of America. PMID 29432176 DOI: 10.1073/Pnas.1717846115  0.372
2018 Cohen JD, Li L, Wang Y, Thoburn C, Afsari B, Danilova L, Douville C, Javed AA, Wong F, Mattox A, Hruban RH, Wolfgang CL, Goggins MG, Dal Molin M, Wang TL, ... ... Kinzler KW, et al. Detection and localization of surgically resectable cancers with a multi-analyte blood test. Science (New York, N.Y.). PMID 29348365 DOI: 10.1126/Science.Aar3247  0.556
2018 Eich M, Springer S, Rodriguez Pena M, Taheri D, Tregnago A, Bezerra S, Cunha I, Fujita K, Ertoy D, Bivalacqua T, Papadopoulos N, Kinzler K, Vogelstein B, Netto G. UroSEEK signature in invasive bladder cancer European Urology Supplements. 17: e2493-e2495. DOI: 10.1016/S1569-9056(18)32978-6  0.334
2018 Springer S, Rodriguez Pena MDC, Tregnago A, Taheri D, Bezerra S, Cunha I, Fujita K, Baydar D, Bivalacqua T, Papadopoulos N, Kinzler KW, Vogelstein B, Netto G. MP65-14 UROSEEK: A NOVEL NON-INVASIVE MOLECULAR ASSAY FOR SURVEILLANCE OF BLADDER CANCER Journal of Urology. 199. DOI: 10.1016/J.Juro.2018.02.2080  0.334
2018 Springer S, Rodriguez Pena MDC, Tregnago A, Taheri D, Bezerra S, Cunha I, Fujita K, Baydar D, Bivalacqua T, Papadopoulos N, Kinzler KW, Vogelstein B, Netto G. MP65-13 UROSEEK: A NOVEL NON-INVASIVE MOLECULAR METHOD FOR EARLY DETECTION OF BLADDER CANCER Journal of Urology. 199. DOI: 10.1016/J.Juro.2018.02.2079  0.321
2017 Cohen JD, Javed AA, Thoburn C, Wong F, Tie J, Gibbs P, Schmidt CM, Yip-Schneider MT, Allen PJ, Schattner M, Brand RE, Singhi AD, Petersen GM, Hong SM, Kim SC, ... ... Kinzler KW, et al. Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 28874546 DOI: 10.1073/Pnas.1704961114  0.425
2017 Rodriguez Pena MDC, Tregnago AC, Eich ML, Springer S, Wang Y, Taheri D, Ertoy D, Fujita K, Bezerra SM, Cunha IW, Raspollini MR, Yu L, Bivalacqua TJ, Papadopoulos N, Kinzler KW, et al. Spectrum of genetic mutations in de novo PUNLMP of the urinary bladder. Virchows Archiv : An International Journal of Pathology. PMID 28597078 DOI: 10.1007/S00428-017-2164-5  0.438
2017 Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, Lu S, Kemberling H, Wilt C, Luber BS, Wong F, Azad NS, Rucki AA, Laheru D, Donehower R, ... ... Kinzler KW, et al. Mismatch-repair deficiency predicts response of solid tumors to PD-1 blockade. Science (New York, N.Y.). PMID 28596308 DOI: 10.1126/Science.Aan6733  0.402
2017 Anglesio MS, Papadopoulos N, Ayhan A, Nazeran TM, Noë M, Horlings HM, Lum A, Jones S, Senz J, Seckin T, Ho J, Wu RC, Lac V, Ogawa H, Tessier-Cloutier B, ... ... Kinzler KW, et al. Cancer-Associated Mutations in Endometriosis without Cancer. The New England Journal of Medicine. 376: 1835-1848. PMID 28489996 DOI: 10.1056/Nejmoa1614814  0.378
2017 Mattox AK, Wang Y, Springer S, Cohen JD, Yegnasubramanian S, Nelson WG, Kinzler KW, Vogelstein B, Papadopoulos N. Bisulfite-converted duplexes for the strand-specific detection and quantification of rare mutations. Proceedings of the National Academy of Sciences of the United States of America. PMID 28416672 DOI: 10.1073/Pnas.1701382114  0.333
2017 Holdhoff M, Cairncross GJ, Kollmeyer TM, Zhang M, Zhang P, Mehta MP, Werner-Wasik M, Souhami L, Bahary JP, Kwok Y, Hartford AC, Chakravarti A, Yegnasubramanian S, Vogelstein B, Papadopoulos N, ... Kinzler K, et al. Genetic landscape of extreme responders with anaplastic oligodendroglioma. Oncotarget. PMID 28388591 DOI: 10.18632/Oncotarget.16773  0.478
2017 Miller MS, Maheshwari S, McRobb FM, Kinzler KW, Amzel LM, Vogelstein B, Gabelli SB. Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design. Bioorganic & Medicinal Chemistry. PMID 28129991 DOI: 10.1016/J.Bmc.2017.01.012  0.573
2017 Makohon-Moore AP, Zhang M, Reiter JG, Bozic I, Allen B, Kundu D, Chatterjee K, Wong F, Jiao Y, Kohutek ZA, Hong J, Attiyeh M, Javier B, Wood LD, Hruban RH, ... ... Kinzler KW, et al. Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer. Nature Genetics. PMID 28092682 DOI: 10.1038/Ng.3764  0.322
2017 Lee B, Cohen J, Lipton LR, Tie J, Javed AA, Li L, Goldstein D, Cooray P, Nagrial A, Burge ME, Tebbutt NC, Nikfarjam M, Harris M, O'Broin-Lennon AM, Wolfgang CL, ... ... Kinzler KW, et al. Potential role of circulating tumor DNA (ctDNA) in the early diagnosis and post-operative management of localised pancreatic cancer. Journal of Clinical Oncology. 35: 4101-4101. DOI: 10.1200/Jco.2017.35.15_Suppl.4101  0.361
2017 Tie J, Cohen J, Wang Y, Li L, Kinde I, Elsaleh H, Wong R, Kosmider S, Yip D, Lee M, Tran B, Burge ME, Goldstein D, Singh MS, Diaz LA, ... ... Kinzler KW, et al. The potential of circulating tumor DNA (ctDNA) to guide adjuvant chemotherapy decision making in locally advanced rectal cancer (LARC). Journal of Clinical Oncology. 35: 3521-3521. DOI: 10.1200/Jco.2017.35.15_Suppl.3521  0.314
2017 Papadopoulos N, Wang Y, Cohen J, Hruban R, Gibbs P, Tie J, Diaz L, Kinzler K, Vogelstein B. Abstract IA17: Non-invasive detection of somatic mutations in the management of CRC Cancer Research. 77. DOI: 10.1158/1538-7445.Crc16-Ia17  0.422
2017 Kinzler KW. Abstract IA03: Lessons from colorectal cancer Cancer Research. 77. DOI: 10.1158/1538-7445.Crc16-Ia03  0.377
2016 Rettig EM, Talbot CC, Sausen M, Jones S, Bishop JA, Wood LD, Tokheim C, Niknafs N, Karchin R, Fertig E, Wheelan S, Marchionni L, Considine M, Ling S, Fakhry C, ... ... Kinzler KW, et al. Correction: Whole-genome sequencing of salivary gland adenoid cystic carcinoma (Cancer Prevention Research (2016) 9 (265-274) DOI: 10.1158/1940-6207.CAPR-15-0316) Cancer Prevention Research. 11. PMID 28642227 DOI: 10.1158/1940-6207.Capr-17-0178  0.305
2016 Tokheim CJ, Papadopoulos N, Kinzler KW, Vogelstein B, Karchin R. Evaluating the evaluation of cancer driver genes. Proceedings of the National Academy of Sciences of the United States of America. PMID 27911828 DOI: 10.1073/Pnas.1616440113  0.372
2016 Kinzler K, Vogelstein B. Necessity Is The Mother of Invention: The Development of Digital Genomics. Clinical Chemistry. PMID 27754860 DOI: 10.1373/Clinchem.2016.262741  0.357
2016 Morin PJ, Kinzler KW, Sparks AB. β-Catenin Mutations: Insights into the APC Pathway and the Power of Genetics. Cancer Research. 76: 5587-5589. PMID 27698186 DOI: 10.1158/0008-5472.Can-16-2387  0.333
2016 Hoang ML, Kinde I, Tomasetti C, McMahon KW, Rosenquist TA, Grollman AP, Kinzler KW, Vogelstein B, Papadopoulos N. Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing. Proceedings of the National Academy of Sciences of the United States of America. PMID 27528664 DOI: 10.1073/Pnas.1607794113  0.34
2016 Nguyen D, Taheri D, Springer S, Cowan M, Guner G, Rodriguez MA, Wang Y, Kinde I, VandenBussche CJ, Olson MT, Ricardo BF, Cunha I, Fujita K, Ertoy D, Kinzler KW, et al. High prevalence of TERT promoter mutations in micropapillary urothelial carcinoma. Virchows Archiv : An International Journal of Pathology. PMID 27520411 DOI: 10.1007/S00428-016-2001-2  0.376
2016 Wang Y, Sundfeldt K, Mateoiu C, Shih IM, Kurman RJ, Schaefer J, Silliman N, Kinde I, Springer S, Foote M, Kristjansdottir B, James N, Kinzler KW, Papadopoulos N, Diaz LA, et al. Diagnostic potential of tumor DNA from ovarian cyst fluid. Elife. 5. PMID 27421040 DOI: 10.7554/Elife.15175  0.414
2016 Tie J, Wang Y, Tomasetti C, Li L, Springer S, Kinde I, Silliman N, Tacey M, Wong HL, Christie M, Kosmider S, Skinner I, Wong R, Steel M, Tran B, ... ... Kinzler KW, et al. Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer. Science Translational Medicine. 8: 346ra92. PMID 27384348 DOI: 10.1126/Scitranslmed.Aaf6219  0.336
2016 Hao Y, Samuels Y, Li Q, Krokowski D, Guan BJ, Wang C, Jin Z, Dong B, Cao B, Feng X, Xiang M, Xu C, Fink S, Meropol NJ, Xu Y, ... ... Kinzler KW, et al. Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer. Nature Communications. 7: 11971. PMID 27321283 DOI: 10.1038/Ncomms11971  0.404
2016 Leung F, Kulasingam V, Diamandis EP, Hoon DS, Kinzler K, Pantel K, Alix-Panabières C. Circulating Tumor DNA as a Cancer Biomarker: Fact or Fiction? Clinical Chemistry. PMID 27259816 DOI: 10.1373/Clinchem.2016.260331  0.387
2016 Cowan M, Springer S, Nguyen D, Taheri D, Guner G, Mendoza Rodriguez MA, Wang Y, Kinde I, Del Carmen Rodriguez Pena M, VandenBussche CJ, Olson M, Cunha I, Fujita K, Ertoy D, Kinzler K, et al. Detection of TERT promoter mutations in primary adenocarcinoma of the urinary bladder. Human Pathology. PMID 26980028 DOI: 10.1016/J.Humpath.2016.02.009  0.391
2016 Cowan M, Springer S, Nguyen D, Taheri D, Guner G, Rodriguez MA, Wang Y, Kinde I, Bussche CJ, Olson MT, Cunha I, Fujita K, Ertoy D, Bivalacqua TJ, Kinzler K, et al. High prevalence of TERT promoter mutations in primary squamous cell carcinoma of the urinary bladder. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. PMID 26965579 DOI: 10.1038/Modpathol.2016.53  0.322
2016 Rettig EM, Talbot C, Sausen M, Jones S, Bishop JA, Wood LD, Tokheim C, Niknafs N, Karchin R, Fertig E, Wheelan S, Marchionni L, Considine M, Fakhry C, Papadopoulos N, ... Kinzler KW, et al. Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma. Cancer Prevention Research (Philadelphia, Pa.). PMID 26862087 DOI: 10.1158/1940-6207.Capr-15-0316  0.307
2016 Robles AI, Traverso G, Zhang M, Roberts NJ, Khan MA, Joseph C, Lauwers GY, Selaru FM, Popoli M, Pittman ME, Ke X, Hruban RH, Meltzer SJ, Kinzler KW, Vogelstein B, et al. Whole-exome Sequencing analyses of Inflammatory Bowel Disease-associated Colorectal Cancers. Gastroenterology. PMID 26764183 DOI: 10.1053/J.Gastro.2015.12.036  0.407
2016 Wang Y, Sundfeldt K, Mateoiu C, Shih I, Kurman RJ, Schaefer J, Silliman N, Kinde I, Springer S, Foote M, Kristjansdottir B, James N, Kinzler KW, Papadopoulos N, Diaz LA, et al. Author response: Diagnostic potential of tumor DNA from ovarian cyst fluid Elife. DOI: 10.7554/Elife.15175.013  0.309
2016 Tie J, Wang Y, Springer S, Kinde I, Wong H, Kosmider S, Tran B, Christie M, Thomson BN, Wong R, Burge ME, Shannon J, Kotasek D, Field KM, Strausberg R, ... ... Kinzler KW, et al. Serial circulating tumor DNA (ctDNA) and recurrence risk in patients (pts) with resectable colorectal liver metastasis (CLM). Journal of Clinical Oncology. 34: e15131-e15131. DOI: 10.1200/Jco.2016.34.15_Suppl.E15131  0.342
2016 Tie J, Wang Y, Tomasetti C, Li L, Springer S, Kinde I, Wong R, Kosmider S, Tran B, Desai J, Hayes TM, Haydon AM, Yip D, Christie M, Strausberg R, ... ... Kinzler KW, et al. The potential of circulating tumor DNA (ctDNA) to reshape the design of clinical trials testing adjuvant therapy in patients with early stage cancers. Journal of Clinical Oncology. 34: 3511-3511. DOI: 10.1200/Jco.2016.34.15_Suppl.3511  0.366
2016 Holdhoff M, Cairncross JG, Jenkins RB, Bettegowda C, Zhang M, Kollmeyer TM, Yegnasubramanian ST, Grossman SA, Vogelstein B, Papadopoulos N, Kinzler KW, Werner-Wasik M, Souhami L, Bahary J, Kwok Y, et al. Genetic landscape of extreme responders with anaplastic oligodendroglioma: NRG Oncology/RTOG 9402. Journal of Clinical Oncology. 34: 2054-2054. DOI: 10.1200/Jco.2016.34.15_Suppl.2054  0.507
2016 Hoang ML, Kinde I, Tomasetti C, Rosenquist T, Grollman AP, Kinzler KW, Vogelstein B, Papadopoulos N. Abstract NG01: Accumulation of somatic mutations in normal and cancerous tissues with age Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Ng01  0.379
2015 Roberts NJ, Norris AL, Petersen GM, Bondy ML, Brand R, Gallinger S, Kurtz RC, Olson SH, Rustgi AK, Schwartz AG, Stoffel EM, Syngal S, Zogopoulos G, Ali SZ, Axilbund J, ... ... Kinzler KW, et al. Whole genome sequencing defines the genetic heterogeneity of familial pancreatic cancer. Cancer Discovery. PMID 26658419 DOI: 10.1158/2159-8290.Cd-15-0402  0.393
2015 Vogelstein B, Kinzler KW. The Path to Cancer --Three Strikes and You're Out. The New England Journal of Medicine. 373: 1895-8. PMID 26559569 DOI: 10.1056/Nejmp1508811  0.452
2015 Maritschnegg E, Wang Y, Pecha N, Horvat R, Van Nieuwenhuysen E, Vergote I, Heitz F, Sehouli J, Kinde I, Diaz LA, Papadopoulos N, Kinzler KW, Vogelstein B, Speiser P, Zeillinger R. Lavage of the Uterine Cavity for Molecular Detection of Müllerian Duct Carcinomas: A Proof-of-Concept Study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. PMID 26552420 DOI: 10.1200/Jco.2015.61.3083  0.438
2015 Ewing AD, Gacita A, Wood LD, Ma F, Xing D, Kim MS, Manda SS, Abril G, Pereira G, Makohon-Moore A, Looijenga LH, Gillis AJ, Hruban RH, Anders RA, Romans KE, ... ... Kinzler KW, et al. Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution. Genome Research. PMID 26260970 DOI: 10.1101/Gr.196238.115  0.383
2015 Skora AD, Douglass J, Hwang MS, Tam AJ, Blosser RL, Gabelli SB, Cao J, Diaz LA, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S. Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes. Proceedings of the National Academy of Sciences of the United States of America. PMID 26216968 DOI: 10.1073/Pnas.1511996112  0.553
2015 Wang Y, Springer S, Zhang M, McMahon KW, Kinde I, Dobbyn L, Ptak J, Brem H, Chaichana K, Gallia GL, Gokaslan ZL, Groves ML, Jallo GI, Lim M, Olivi A, ... ... Kinzler KW, et al. Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord. Proceedings of the National Academy of Sciences of the United States of America. PMID 26195750 DOI: 10.1073/Pnas.1511694112  0.495
2015 Perica K, Bieler JG, Schütz C, Varela JC, Douglass J, Skora A, Chiu YL, Oelke M, Kinzler K, Zhou S, Vogelstein B, Schneck JP. Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy. Acs Nano. 9: 6861-71. PMID 26171764 DOI: 10.1021/Acsnano.5B02829  0.356
2015 Wang Y, Springer S, Mulvey CL, Silliman N, Schaefer J, Sausen M, James N, Rettig EM, Guo T, Pickering CR, Bishop JA, Chung CH, Califano JA, Eisele DW, Fakhry C, ... ... Kinzler KW, et al. Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas. Science Translational Medicine. 7: 293ra104. PMID 26109104 DOI: 10.1126/Scitranslmed.Aaa8507  0.506
2015 Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, Skora AD, Luber BS, Azad NS, Laheru D, Biedrzycki B, Donehower RC, Zaheer A, Fisher GA, Crocenzi TS, ... ... Kinzler KW, et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. The New England Journal of Medicine. 372: 2509-20. PMID 26028255 DOI: 10.1200/Jco.2015.33.18_Suppl.Lba100  0.357
2015 Tie J, Kinde I, Wang Y, Wong HL, Roebert J, Christie M, Tacey M, Wong R, Singh M, Karapetis CS, Desai J, Tran B, Strausberg RL, Diaz LA, Papadopoulos N, ... Kinzler KW, et al. Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. PMID 25851626 DOI: 10.1093/Annonc/Mdv177  0.385
2015 Llosa NJ, Cruise M, Tam A, Wicks EC, Hechenbleikner EM, Taube JM, Blosser RL, Fan H, Wang H, Luber BS, Zhang M, Papadopoulos N, Kinzler KW, Vogelstein B, Sears CL, et al. The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Cancer Discovery. 5: 43-51. PMID 25358689 DOI: 10.1158/2159-8290.Cd-14-0863  0.384
2015 Tie J, Wang Y, Kinde I, Steel M, Elsaleh H, Singh MS, Turner NH, Tran B, Strausberg R, Diaz LA, Papadopoulos N, Kinzler KW, Vogelstein B, Gibbs P. Circulating tumor DNA (ctDNA) in nonmetastatic colorectal cancer (CRC): Potential role as a screening tool. Journal of Clinical Oncology. 33: 518-518. DOI: 10.1200/Jco.2015.33.3_Suppl.518  0.398
2015 Miller M, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB. Abstract PR02: Targeting PI3K: The PIP2 binding site Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Pi3K14-Pr02  0.576
2015 Sur S, Chapiro J, Savic LJ, Kaniappan GS, Reyes J, Duran R, Thiruganasambandam SC, Moats CR, Luo W, Ewald AJ, Zhou S, Kinzler KW, Geschwind J, Vogelstein B. Abstract NG06: The Trojan Horse Strategy: Packaging chemotherapeutics can help alleviate toxicity Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Ng06  0.334
2015 Llosa NJ, Cruise M, Tam A, Wick E, Hechenbleikner E, Taube J, Blosser L, Fan H, Wang H, Zhang M, Luber B, Papadopoulos N, Kinzler K, Vogelstein B, Sears C, et al. Abstract 451: The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints Cancer Research. 75: 451-451. DOI: 10.1158/1538-7445.Am2015-451  0.315
2015 Makohon-Moore AP, Zhang M, Reiter JG, Bozic I, Wong F, Jiao Y, Chatterjee K, Nowak MA, Papadopoulos N, Vogelstein B, Kinzler KW, Iacobuzio-Donahue CA. Abstract 4137: Clonal evolution defines the natural history of metastatic pancreatic cancer Cancer Research. 75: 4137-4137. DOI: 10.1158/1538-7445.Am2015-4137  0.407
2014 Dejea CM, Wick EC, Hechenbleikner EM, White JR, Mark Welch JL, Rossetti BJ, Peterson SN, Snesrud EC, Borisy GG, Lazarev M, Stein E, Vadivelu J, Roslani AC, Malik AA, Wanyiri JW, ... ... Kinzler KW, et al. Microbiota organization is a distinct feature of proximal colorectal cancers. Proceedings of the National Academy of Sciences of the United States of America. 111: 18321-6. PMID 25489084 DOI: 10.1073/Pnas.1406199111  0.373
2014 Erickson BK, Kinde I, Dobbin ZC, Wang Y, Martin JY, Alvarez RD, Conner MG, Huh WK, Roden RB, Kinzler KW, Papadopoulos N, Vogelstein B, Diaz LA, Landen CN. Detection of somatic TP53 mutations in tampons of patients with high-grade serous ovarian cancer. Obstetrics and Gynecology. 124: 881-5. PMID 25437714 DOI: 10.1097/AOG.0000000000000484  0.305
2014 Zhang M, Wang Y, Jones S, Sausen M, McMahon K, Sharma R, Wang Q, Belzberg AJ, Chaichana K, Gallia GL, Gokaslan ZL, Riggins GJ, Wolinksy JP, Wood LD, Montgomery EA, ... ... Kinzler KW, et al. Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. Nature Genetics. 46: 1170-2. PMID 25305755 DOI: 10.1038/Ng.3116  0.491
2014 Roberts NJ, Zhang L, Janku F, Collins A, Bai RY, Staedtke V, Rusk AW, Tung D, Miller M, Roix J, Khanna KV, Murthy R, Benjamin RS, Helgason T, Szvalb AD, ... ... Kinzler KW, et al. Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses. Science Translational Medicine. 6: 249ra111. PMID 25122639 DOI: 10.1126/Scitranslmed.3008982  0.745
2014 Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB. Structural basis of nSH2 regulation and lipid binding in PI3Kα. Oncotarget. 5: 5198-208. PMID 25105564 DOI: 10.18632/Oncotarget.2263  0.522
2014 Kim K, Skora AD, Li Z, Liu Q, Tam AJ, Blosser RL, Diaz LA, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S. Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 11774-9. PMID 25071169 DOI: 10.1073/Pnas.1410626111  0.367
2014 Li R, Faden DL, Fakhry C, Langelier C, Jiao Y, Wang Y, Wilkerson MD, Pedamallu CS, Old M, Lang J, Loyo M, Ahn SM, Tan M, Gooi Z, Chan J, ... ... Kinzler KW, et al. Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke. Head & Neck. PMID 24954188 DOI: 10.1002/Hed.23807  0.47
2014 Lennon AM, Wolfgang CL, Canto MI, Klein AP, Herman JM, Goggins M, Fishman EK, Kamel I, Weiss MJ, Diaz LA, Papadopoulos N, Kinzler KW, Vogelstein B, Hruban RH. The early detection of pancreatic cancer: what will it take to diagnose and treat curable pancreatic neoplasia? Cancer Research. 74: 3381-9. PMID 24924775 DOI: 10.1158/0008-5472.Can-14-0734  0.324
2014 Esserman LJ, Thompson IM, Reid B, Nelson P, Ransohoff DF, Welch HG, Hwang S, Berry DA, Kinzler KW, Black WC, Bissell M, Parnes H, Srivastava S. Addressing overdiagnosis and overtreatment in cancer: a prescription for change. The Lancet. Oncology. 15: e234-42. PMID 24807866 DOI: 10.1016/S1470-2045(13)70598-9  0.321
2014 Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, Bartlett BR, Wang H, Luber B, Alani RM, Antonarakis ES, Azad NS, Bardelli A, Brem H, Cameron JL, ... ... Kinzler KW, et al. Detection of circulating tumor DNA in early- and late-stage human malignancies. Science Translational Medicine. 6: 224ra24. PMID 24553385 DOI: 10.1126/Scitranslmed.3007094  0.616
2014 Chan KW, Yu T, Qiao Y, Liu Q, Yang M, Patel H, Liu G, Kinzler KW, Vogelstein B, Bulte JW, van Zijl PC, Hanes J, Zhou S, McMahon MT. A diaCEST MRI approach for monitoring liposomal accumulation in tumors. Journal of Controlled Release : Official Journal of the Controlled Release Society. 180: 51-9. PMID 24548481 DOI: 10.1016/J.Jconrel.2014.02.005  0.346
2014 Matthaei H, Wu J, Dal Molin M, Shi C, Perner S, Kristiansen G, Lingohr P, Kalff JC, Wolfgang CL, Kinzler KW, Vogelstein B, Maitra A, Hruban RH. GNAS sequencing identifies IPMN-specific mutations in a subgroup of diminutive pancreatic cysts referred to as "Incipient IPMNs" American Journal of Surgical Pathology. 38: 360-363. PMID 24525507 DOI: 10.1097/Pas.0000000000000117  0.337
2014 Jiao Y, Yonescu R, Offerhaus GJ, Klimstra DS, Maitra A, Eshleman JR, Herman JG, Poh W, Pelosof L, Wolfgang CL, Vogelstein B, Kinzler KW, Hruban RH, Papadopoulos N, Wood LD. Whole-exome sequencing of pancreatic neoplasms with acinar differentiation. The Journal of Pathology. 232: 428-35. PMID 24293293 DOI: 10.1002/Path.4310  0.381
2014 Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB. Abstract LB-326: Structural basis of lipid-binding and regulation in PI3Kα Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-326  0.594
2014 Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB. Structural basis of nSH2 regulation and lipid binding in PI3Kα Oncotarget. 5: 5198-5208.  0.491
2013 Jiao Y, Pawlik TM, Anders RA, Selaru FM, Streppel MM, Lucas DJ, Niknafs N, Guthrie VB, Maitra A, Argani P, Offerhaus GJ, Roa JC, Roberts LR, Gores GJ, Popescu I, ... ... Kinzler KW, et al. Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas. Nature Genetics. 45: 1470-3. PMID 24185509 DOI: 10.1038/Ng.2813  0.377
2013 Liu G, Bettegowda C, Qiao Y, Staedtke V, Chan KW, Bai R, Li Y, Riggins GJ, Kinzler KW, Bulte JW, McMahon MT, Gilad AA, Vogelstein B, Zhou S, van Zijl PC. Noninvasive imaging of infection after treatment with tumor-homing bacteria using Chemical Exchange Saturation Transfer (CEST) MRI. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 70: 1690-8. PMID 24123389 DOI: 10.1002/Mrm.24955  0.52
2013 Yang J, Hendricks W, Liu G, McCaffery JM, Kinzler KW, Huso DL, Vogelstein B, Zhou S. A nanoparticle formulation that selectively transfects metastatic tumors in mice Proceedings of the National Academy of Sciences of the United States of America. 110: 14717-14722. PMID 23959886 DOI: 10.1073/Pnas.1313330110  0.366
2013 Hoang ML, Chen CH, Sidorenko VS, He J, Dickman KG, Yun BH, Moriya M, Niknafs N, Douville C, Karchin R, Turesky RJ, Pu YS, Vogelstein B, Papadopoulos N, Grollman AP, ... Kinzler KW, et al. Mutational signature of aristolochic acid exposure as revealed by whole-exome sequencing Science Translational Medicine. 5. PMID 23926200 DOI: 10.1126/Scitranslmed.3006200  0.398
2013 He J, Wu J, Jiao Y, Rodriguez FJ, Blakeley JO, Kinzler KW, Papadopoulos N, Vogelstein B, Holdhoff M. Limited detection of IgH gene rearrangements in plasma of patients with primary central nervous system lymphoma. Journal of Neuro-Oncology. 114: 275-9. PMID 23828278 DOI: 10.1007/S11060-013-1182-7  0.304
2013 Bettegowda C, Agrawal N, Jiao Y, Wang Y, Wood LD, Rodriguez FJ, Hruban RH, Gallia GL, Binder ZA, Riggins CJ, Salmasi V, Riggins GJ, Reitman ZJ, Rasheed A, Keir S, ... ... Kinzler KW, et al. Exomic sequencing of four rare central nervous system tumor types. Oncotarget. 4: 572-83. PMID 23592488 DOI: 10.18632/Oncotarget.964  0.576
2013 Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA, Kinzler KW. Cancer genome landscapes. Science (New York, N.Y.). 339: 1546-58. PMID 23539594 DOI: 10.1126/Science.1235122  0.47
2013 Killela PJ, Reitman ZJ, Jiao Y, Bettegowda C, Agrawal N, Diaz LA, Friedman AH, Friedman H, Gallia GL, Giovanella BC, Grollman AP, He TC, He Y, Hruban RH, Jallo GI, ... ... Kinzler KW, et al. TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proceedings of the National Academy of Sciences of the United States of America. 110: 6021-6. PMID 23530248 DOI: 10.1093/Neuonc/Nou206.18  0.59
2013 Kinde I, Bettegowda C, Wang Y, Wu J, Agrawal N, Shih IeM, Kurman R, Dao F, Levine DA, Giuntoli R, Roden R, Eshleman JR, Carvalho JP, Marie SK, Papadopoulos N, ... Kinzler KW, et al. Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers. Science Translational Medicine. 5: 167ra4. PMID 23303603 DOI: 10.1126/Scitranslmed.3004952  0.62
2013 Agrawal N, Jiao Y, Sausen M, Leary R, Bettegowda C, Roberts NJ, Bhan S, Ho AS, Khan Z, Bishop J, Westra WH, Wood LD, Hruban RH, Tufano RP, Robinson B, ... ... Kinzler KW, et al. Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS. The Journal of Clinical Endocrinology and Metabolism. 98: E364-9. PMID 23264394 DOI: 10.1210/Jc.2012-2703  0.583
2013 Vogelstein B, Kinzler KW. Abstract DL01-01: Cancer Genomes and their Implications for Early Detection Cancer Prevention Research. 6. DOI: 10.1158/1940-6215.Prev-13-Dl01-01  0.4
2012 Leary RJ, Sausen M, Kinde I, Papadopoulos N, Carpten JD, Craig D, O'Shaughnessy J, Kinzler KW, Parmigiani G, Vogelstein B, Diaz LA, Velculescu VE. Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing. Science Translational Medicine. 4: 162ra154. PMID 23197571 DOI: 10.1126/Scitranslmed.3004742  0.434
2012 Matthaei H, Wu J, Dal Molin M, Debeljak M, Lingohr P, Katabi N, Klimstra DS, Adsay NV, Eshleman JR, Schulick RD, Kinzler KW, Vogelstein B, Hruban RH, Maitra A. GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct Hpb. 14: 677-682. PMID 22954004 DOI: 10.1055/S-0032-1324039  0.333
2012 Agrawal N, Jiao Y, Bettegowda C, Hutfless SM, Wang Y, David S, Cheng Y, Twaddell WS, Latt NL, Shin EJ, Wang LD, Wang L, Yang W, Velculescu VE, Vogelstein B, ... ... Kinzler KW, et al. Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma. Cancer Discovery. 2: 899-905. PMID 22877736 DOI: 10.1158/2159-8290.Cd-12-0189  0.569
2012 Jiao Y, Killela PJ, Reitman ZJ, Rasheed AB, Heaphy CM, de Wilde RF, Rodriguez FJ, Rosemberg S, Oba-Shinjo SM, Nagahashi Marie SK, Bettegowda C, Agrawal N, Lipp E, Pirozzi C, Lopez G, ... ... Kinzler KW, et al. Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. Oncotarget. 3: 709-22. PMID 22869205 DOI: 10.18632/Oncotarget.588  0.564
2012 Lovejoy CA, Li W, Reisenweber S, Thongthip S, Bruno J, de Lange T, De S, Petrini JH, Sung PA, Jasin M, Rosenbluh J, Zwang Y, Weir BA, Hatton C, Ivanova E, ... ... Kinzler K, et al. Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. Plos Genetics. 8: e1002772. PMID 22829774 DOI: 10.1371/Journal.Pgen.1002772  0.433
2012 Cui Y, Brosnan JA, Blackford AL, Sur S, Hruban RH, Kinzler KW, Vogelstein B, Maitra A, Diaz LA, Iacobuzio-Donahue CA, Eshleman JR. Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 6519-30. PMID 22753594 DOI: 10.1158/1078-0432.Ccr-12-0827  0.369
2012 Diaz LA, Williams RT, Wu J, Kinde I, Hecht JR, Berlin J, Allen B, Bozic I, Reiter JG, Nowak MA, Kinzler KW, Oliner KS, Vogelstein B. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature. 486: 537-40. PMID 22722843 DOI: 10.1038/Nature11219  0.361
2012 Roberts NJ, Jiao Y, Yu J, Kopelovich L, Petersen GM, Bondy ML, Gallinger S, Schwartz AG, Syngal S, Cote ML, Axilbund J, Schulick R, Ali SZ, Eshleman JR, Velculescu VE, ... ... Kinzler KW, et al. ATM mutations in patients with hereditary pancreatic cancer Cancer Discovery. 2: 41-46. PMID 22585167 DOI: 10.1158/2159-8290.Cd-11-0194  0.406
2012 Willard MD, Lajiness ME, Wulur IH, Feng B, Swearingen ML, Uhlik MT, Kinzler KW, Velculescu VE, Sjöblom T, Markowitz SD, Powell SM, Vogelstein B, Barber TD. Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes. Molecular Cancer Research : McR. 10: 739-49. PMID 22516348 DOI: 10.1158/1541-7786.Mcr-11-0483  0.378
2012 Jones S, Wang TL, Kurman RJ, Nakayama K, Velculescu VE, Vogelstein B, Kinzler KW, Papadopoulos N, Shih IM. Low-grade serous carcinomas of the ovary contain very few point mutations Journal of Pathology. 226: 413-420. PMID 22102435 DOI: 10.1002/Path.3967  0.349
2012 Ahlquist DA, Zou H, Domanico M, Mahoney DW, Yab TC, Taylor WR, Butz ML, Thibodeau SN, Rabeneck L, Paszat LF, Kinzler KW, Vogelstein B, Bjerregaard NC, Laurberg S, Sørensen HT, et al. Next-generation stool DNA test accurately detects colorectal cancer and large adenomas. Gastroenterology. 142: 248-56; quiz e25-6. PMID 22062357 DOI: 10.1053/J.Gastro.2011.10.031  0.306
2012 Jones S, Li M, Williams Parsons D, Zhang X, Wesseling J, Kristel P, Schmidt MK, Markowitz S, Yan H, Bigner D, Hruban RH, Eshleman JR, Iacobuzio-Donahue CA, Goggins M, Maitra A, ... ... Kinzler KW, et al. Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types Human Mutation. 33: 100-103. PMID 22009941 DOI: 10.1002/Humu.21633  0.634
2012 Roberts NJ, Jiao Y, Yu J, Kopelovich L, Petersen GM, Bondy M, Gallinger S, Schwartz AG, Syngal S, Cote ML, Axilbund J, Schulick R, Ali SZ, Eshleman JR, Velculescu V, ... ... Kinzler KW, et al. Abstract 2628: Genome-wide sequencing identifiesATMas a pancreatic cancer susceptibility gene Cancer Research. 72: 2628-2628. DOI: 10.1158/1538-7445.Am2012-2628  0.4
2011 Diaz LA, Jiao Y, Shi C, Edil BH, de Wilde R, Klimstra DS, Maitra A, Tang LH, Blackford AL, Velculescu V, Vogelstein B, Kinzler KW, Hruban RH, Papadopoulos N. Exomic sequencing of pancreatic neuroendocrine tumors: Detection of alterations in chromatin remodeling and mTOR pathway genes. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 10501. PMID 28022366 DOI: 10.1200/Jco.2011.29.15_Suppl.10501  0.372
2011 Wu J, Jiao Y, Dal Molin M, Maitra A, de Wilde RF, Wood LD, Eshleman JR, Goggins MG, Wolfgang CL, Canto MI, Schulick RD, Edil BH, Choti MA, Adsay V, Klimstra DS, ... ... Kinzler KW, et al. Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proceedings of the National Academy of Sciences of the United States of America. 108: 21188-93. PMID 22158988 DOI: 10.1073/Pnas.1118046108  0.432
2011 Li M, Collins R, Jiao Y, Ouillette P, Bixby D, Erba H, Vogelstein B, Kinzler KW, Papadopoulos N, Malek SN. Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia Blood. 118: 5914-5917. PMID 21989985 DOI: 10.1182/Blood-2011-05-356204  0.396
2011 Li M, Zhao H, Zhang X, Wood LD, Anders RA, Choti MA, Pawlik TM, Daniel HD, Kannangai R, Offerhaus GJ, Velculescu VE, Wang L, Zhou S, Vogelstein B, Hruban RH, ... ... Kinzler KW, et al. Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. Nature Genetics. 43: 828-9. PMID 21822264 DOI: 10.1038/Ng.903  0.481
2011 Bettegowda C, Agrawal N, Jiao Y, Sausen M, Wood LD, Hruban RH, Rodriguez FJ, Cahill DP, McLendon R, Riggins G, Velculescu VE, Oba-Shinjo SM, Marie SK, Vogelstein B, Bigner D, ... ... Kinzler KW, et al. Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science (New York, N.Y.). 333: 1453-5. PMID 21817013 DOI: 10.1126/Science.1210557  0.537
2011 Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, Zhang N, El-Naggar AK, Jasser SA, Weinstein JN, Treviño L, ... ... Kinzler KW, et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science (New York, N.Y.). 333: 1154-7. PMID 21798897 DOI: 10.1126/Science.1206923  0.556
2011 Wu J, Matthaei H, Maitra A, Dal Molin M, Wood LD, Eshleman JR, Goggins M, Canto MI, Schulick RD, Edil BH, Wolfgang CL, Klein AP, Diaz LA, Allen PJ, Schmidt CM, ... Kinzler KW, et al. Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development. Science Translational Medicine. 3: 92ra66. PMID 21775669 DOI: 10.1126/Scitranslmed.3002543  0.362
2011 Heaphy CM, de Wilde RF, Jiao Y, Klein AP, Edil BH, Shi C, Bettegowda C, Rodriguez FJ, Eberhart CG, Hebbar S, Offerhaus GJ, McLendon R, Rasheed BA, He Y, Yan H, ... ... Kinzler KW, et al. Altered telomeres in tumors with ATRX and DAXX mutations. Science (New York, N.Y.). 333: 425. PMID 21719641 DOI: 10.1126/Science.1207313  0.589
2011 Zhang X, Reis M, Khoriaty R, Li Y, Ouillette P, Samayoa J, Carter H, Karchin R, Li M, Diaz LA, Velculescu VE, Papadopoulos N, Kinzler KW, Vogelstein B, Malek SN. Sequence analysis of 515 kinase genes in chronic lymphocytic leukemia. Leukemia. 25: 1908-10. PMID 21701494 DOI: 10.1038/Leu.2011.163  0.61
2011 Holdhoff M, Schmidt K, Diehl F, Aggrawal N, Angenendt P, Romans K, Edelstein DL, Torbenson M, Kinzler KW, Vogelstein B, Choti MA, Diaz LA. Detection of tumor DNA at the margins of colorectal cancer liver metastasis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 3551-7. PMID 21531819 DOI: 10.1158/1078-0432.Ccr-10-3087  0.404
2011 He J, Wu J, Jiao Y, Wagner-Johnston N, Ambinder RF, Diaz LA, Kinzler KW, Vogelstein B, Papadopoulos N. IgH gene rearrangements as plasma biomarkers in Non- Hodgkin's lymphoma patients. Oncotarget. 2: 178-85. PMID 21399237 DOI: 10.18632/Oncotarget.235  0.338
2011 Qiao Y, Huang X, Nimmagadda S, Bai R, Staedtke V, Foss CA, Cheong I, Holdhoff M, Kato Y, Pomper MG, Riggins GJ, Kinzler KW, Diaz LA, Vogelstein B, Zhou S. A robust approach to enhance tumor-selective accumulation of nanoparticles. Oncotarget. 2: 59-68. PMID 21378416 DOI: 10.18632/Oncotarget.227  0.309
2011 Reitman ZJ, Jin G, Karoly ED, Spasojevic I, Yang J, Kinzler KW, He Y, Bigner DD, Vogelstein B, Yan H. Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome. Proceedings of the National Academy of Sciences of the United States of America. 108: 3270-5. PMID 21289278 DOI: 10.1073/Pnas.1019393108  0.365
2011 Jiao Y, Shi C, Edil BH, de Wilde RF, Klimstra DS, Maitra A, Schulick RD, Tang LH, Wolfgang CL, Choti MA, Velculescu VE, Diaz LA, Vogelstein B, Kinzler KW, Hruban RH, et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science (New York, N.Y.). 331: 1199-203. PMID 21252315 DOI: 10.1126/Science.1200609  0.32
2011 Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, ... ... Kinzler KW, et al. The genetic landscape of the childhood cancer medulloblastoma. Science (New York, N.Y.). 331: 435-9. PMID 21163964 DOI: 10.1126/Science.1198056  0.694
2011 Guerrero-Preston R, Agrawal N, Sidransky D, Li RJ, Westra WH, Koch WM, Califano JA, Vogelstein B, Velculescu VE, Papadopoulos N, Kinzler KW. Abstract PR3: Exome sequencing of head and neck squamous cell carcinoma reveals a higher frequency of mutations in TP53 among African Americans Cancer Epidemiology, Biomarkers & Prevention. 20. DOI: 10.1158/1055-9965.Disp-11-Pr3  0.403
2010 Schmidt-Kittler O, Zhu J, Yang J, Liu G, Hendricks W, Lengauer C, Gabelli SB, Kinzler KW, Vogelstein B, Huso DL, Zhou S. PI3Kα inhibitors that inhibit metastasis. Oncotarget. 1: 339-348. PMID 21179398 DOI: 10.18632/Oncotarget.166  0.624
2010 Boca SM, Kinzler KW, Velculescu VE, Vogelstein B, Parmigiani G. Patient-oriented gene set analysis for cancer mutation data Genome Biology. 11. PMID 21092299 DOI: 10.1186/Gb-2010-11-11-R112  0.396
2010 Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, Kamiyama M, Hruban RH, Eshleman JR, Nowak MA, Velculescu VE, Kinzler KW, Vogelstein B, Iacobuzio-Donahue CA. Distant metastasis occurs late during the genetic evolution of pancreatic cancer Nature. 467: 1114-1117. PMID 20981102 DOI: 10.1038/Nature09515  0.388
2010 Bozic I, Antal T, Ohtsuki H, Carter H, Kim D, Chen S, Karchin R, Kinzler KW, Vogelstein B, Nowak MA. Accumulation of driver and passenger mutations during tumor progression Proceedings of the National Academy of Sciences of the United States of America. 107: 18545-18550. PMID 20876136 DOI: 10.1073/Pnas.1010978107  0.42
2010 Jones S, Wang TL, Shih IeM, Mao TL, Nakayama K, Roden R, Glas R, Slamon D, Diaz LA, Vogelstein B, Kinzler KW, Velculescu VE, Papadopoulos N. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science (New York, N.Y.). 330: 228-31. PMID 20826764 DOI: 10.1126/Science.1196333  0.467
2010 Leary RJ, Kinde I, Diehl F, Schmidt K, Clouser C, Duncan C, Antipova A, Lee C, McKernan K, De La Vega FM, Kinzler KW, Vogelstein B, Diaz LA, Velculescu VE. Development of personalized tumor biomarkers using massively parallel sequencing. Science Translational Medicine. 2: 20ra14. PMID 20371490 DOI: 10.1126/Scitranslmed.3000702  0.424
2010 Ericson K, Gan C, Cheong I, Rago C, Samuels Y, Velculescu VE, Kinzler KW, Huso DL, Vogelstein B, Papadopoulos N. Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation. Proceedings of the National Academy of Sciences of the United States of America. 107: 2598-603. PMID 20133737 DOI: 10.1073/Pnas.0914018107  0.371
2010 Schmidt K, Holdhoff M, Diehl F, Angenendt P, Agrawal N, Judge K, Kinzler KW, Vogelstein B, Choti MA, Diaz LA. Mutation-based detection of molecular tumor margins in colorectal liver metastasis. Journal of Clinical Oncology. 28: 3610-3610. DOI: 10.1200/Jco.2010.28.15_Suppl.3610  0.384
2010 Zhang X, Li M, Ouillette P, Diaz L, Reis M, Velculescu V, Kinzler K, Malek S, Vogelstein B. Identification of Somatically Acquired Gene Mutations In the Kineome and Exome In CLL Blood. 116: 2410-2410. DOI: 10.1182/Blood.V116.21.2410.2410  0.625
2010 Ericson K, Gan C, Cheong I, Rago C, Samuels Y, Velculescu VE, Kinzler KW, Huso DL, Vogelstein B, Papadopoulos N. Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation (Proceedings of the National Academy of Sciences of the United States of America (2010) 107 (2598-2603) DOI: 10.1073/pnas.0914018107) Proceedings of the National Academy of Sciences of the United States of America. 107: 6551. DOI: 10.1073/Pnas.1002415107  0.379
2009 Mandelker D, Gabelli SB, Schmidt-Kittler O, Zhu J, Cheong I, Huang CH, Kinzler KW, Vogelstein B, Amzel LM. A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane Proceedings of the National Academy of Sciences of the United States of America. 106: 16996-17001. PMID 19805105 DOI: 10.1073/Pnas.0908444106  0.607
2009 Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Willson JK, Markowitz S, Zhou S, Diaz LA, Velculescu VE, Lengauer C, Kinzler KW, Vogelstein B, et al. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science (New York, N.Y.). 325: 1555-9. PMID 19661383 DOI: 10.1126/Science.1174229  0.385
2009 Carter H, Chen S, Isik L, Tyekucheva S, Velculescu VE, Kinzler KW, Vogelstein B, Karchin R. Cancer-specific high-throughput annotation of somatic mutations: Computational prediction of driver missense mutations Cancer Research. 69: 6660-6667. PMID 19654296 DOI: 10.1158/0008-5472.Can-09-1133  0.384
2009 Guda K, Moinova H, He J, Jamison O, Ravi L, Natale L, Lutterbaugh J, Lawrence E, Lewis S, Willson JKV, Lowe JB, Wiesner GL, Parmigiani G, Barnholtz-Sloan J, Dawson DW, ... ... Kinzler KW, et al. Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers Proceedings of the National Academy of Sciences of the United States of America. 106: 12921-12925. PMID 19617566 DOI: 10.1073/Pnas.0901454106  0.44
2009 Blackford A, Serrano OK, Wolfgang CL, Parmigiani G, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Cameron JL, ... ... Kinzler KW, et al. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 4674-9. PMID 19584151 DOI: 10.1158/1078-0432.Ccr-09-0227  0.64
2009 Duncan CG, Leary RJ, Lin JC, Cummins J, Di C, Schaefer CF, Wang TL, Riggins GJ, Edwards J, Bigner D, Kopelovich L, Vogelstein B, Kinzler KW, Velculescu VE, Yan H. Identification of microbial DNA in human cancer. Bmc Medical Genomics. 2: 22. PMID 19426505 DOI: 10.1186/1755-8794-2-22  0.374
2009 Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JCH, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, ... ... Kinzler KW, et al. Genetic mutations associated with Cigarette smoking in pancreatic cancer Cancer Research. 69: 3681-3688. PMID 19351817 DOI: 10.1158/0008-5472.Can-09-0015  0.597
2009 Jones S, Hruban RH, Kamiyama M, Borges M, Zhang X, Parsons DW, Lin JCH, Palmisano E, Brune K, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Parmigiani G, Kern SE, Velculescu VE, ... Kinzler KW, et al. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene Science. 324: 217. PMID 19264984 DOI: 10.1126/Science.1171202  0.627
2009 Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, et al. IDH1 and IDH2 mutations in gliomas. The New England Journal of Medicine. 360: 765-73. PMID 19228619 DOI: 10.1056/Nejmoa0808710  0.305
2009 Sur S, Pagliarini R, Bunz F, Rago C, Diaz LA, Kinzler KW, Vogelstein B, Papadopoulos N. A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53. Proceedings of the National Academy of Sciences of the United States of America. 106: 3964-9. PMID 19225112 DOI: 10.1073/Pnas.0813333106  0.42
2009 Parmigiani G, Boca S, Lin J, Kinzler KW, Velculescu V, Vogelstein B. Design and analysis issues in genome-wide somatic mutation studies of cancer Genomics. 93: 17-21. PMID 18692126 DOI: 10.1016/J.Ygeno.2008.07.005  0.315
2008 Diehl F, Schmidt K, Choti MA, Goodman S, Romans K, Thornton K, Kinzler K, Vogelstein B, Diaz LA. Circulating tumor DNA as a cancer biomarker. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 4122. PMID 27950955 DOI: 10.1200/Jco.2008.26.15_Suppl.4122  0.441
2008 Leary RJ, Lin JC, Cummins J, Boca S, Wood LD, Parsons DW, Jones S, Sjöblom T, Park BH, Parsons R, Willis J, Dawson D, Willson JK, Nikolskaya T, Nikolsky Y, ... ... Kinzler KW, et al. Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proceedings of the National Academy of Sciences of the United States of America. 105: 16224-9. PMID 18852474 DOI: 10.1073/Pnas.0808041105  0.43
2008 Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, ... ... Kinzler KW, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (New York, N.Y.). 321: 1801-6. PMID 18772397 DOI: 10.1126/Science.1164368  0.592
2008 Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, Olivi A, McLendon R, Rasheed BA, Keir S, Nikolskaya T, ... ... Kinzler KW, et al. An integrated genomic analysis of human glioblastoma multiforme. Science (New York, N.Y.). 321: 1807-12. PMID 18772396 DOI: 10.1126/Science.1164382  0.604
2008 Jones S, Chen WD, Parmigiani G, Diehl F, Beerenwinkel N, Antal T, Traulsen A, Nowak MA, Siegel C, Velculescu VE, Kinzler KW, Vogelstein B, Willis J, Markowitz SD. Comparative lesion sequencing provides insights into tumor evolution. Proceedings of the National Academy of Sciences of the United States of America. 105: 4283-8. PMID 18337506 DOI: 10.1073/Pnas.0712345105  0.463
2008 Barber TD, McManus K, Yuen KW, Reis M, Parmigiani G, Shen D, Barrett I, Nouhi Y, Spencer F, Markowitz S, Velculescu VE, Kinzler KW, Vogelstein B, Lengauer C, Hieter P. Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proceedings of the National Academy of Sciences of the United States of America. 105: 3443-8. PMID 18299561 DOI: 10.1073/Pnas.0712384105  0.425
2008 Segal NH, Parsons DW, Peggs KS, Velculescu V, Kinzler KW, Vogelstein B, Allison JP. Epitope landscape in breast and colorectal cancer Cancer Research. 68: 889-892. PMID 18245491 DOI: 10.1158/0008-5472.Can-07-3095  0.447
2007 Huang CH, Mandelker D, Schmidt-Kittler O, Samuels Y, Velculescu VE, Kinzler KW, Vogelstein B, Gabelli SB, Amzel LM. The structure of a human p110α/p85α complex elucidates the effects of oncogenic PI3Kα mutations Science. 318: 1744-1748. PMID 18079394 DOI: 10.1126/Science.1150799  0.613
2007 Beerenwinkel N, Antal T, Dingli D, Traulsen A, Kinzler KW, Velculescu VE, Vogelstein B, Nowak MA. Genetic progression and the waiting time to cancer. Plos Computational Biology. 3: e225. PMID 17997597 DOI: 10.1371/Journal.Pcbi.0030225  0.422
2007 Wood LD, Parsons DW, Jones S, Lin J, Sjöblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, ... ... Kinzler KW, et al. The genomic landscapes of human breast and colorectal cancers. Science (New York, N.Y.). 318: 1108-13. PMID 17932254 DOI: 10.1126/science.1145720  0.363
2007 Diaz LA, Foss CA, Thornton K, Nimmagadda S, Endres CJ, Uzuner O, Seyler TM, Ulrich SD, Conway J, Bettegowda C, Agrawal N, Cheong I, Zhang X, Ladenson PW, Vogelstein BN, ... ... Kinzler KW, et al. Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT. Plos One. 2: e1007. PMID 17925855 DOI: 10.1371/Journal.Pone.0001007  0.602
2007 Rago C, Huso DL, Diehl F, Karim B, Liu G, Papadopoulos N, Samuels Y, Velculescu VE, Vogelstein B, Kinzler KW, Diaz LA. Serial assessment of human tumor burdens in mice by the analysis of circulating DNA. Cancer Research. 67: 9364-70. PMID 17909045 DOI: 10.1158/0008-5472.Can-07-0605  0.354
2007 Lin J, Gan CM, Zhang X, Jones S, Sjöblom T, Wood LD, Parsons DW, Papadopoulos N, Kinzler KW, Vogelstein B, Parmigiani G, Velculescu VE. A multidimensional analysis of genes mutated in breast and colorectal cancers Genome Research. 17: 1304-1318. PMID 17693572 DOI: 10.1101/Gr.6431107  0.633
2007 Plomp M, McCaffery JM, Cheong I, Huang X, Bettegowda C, Kinzler KW, Zhou S, Vogelstein B, Malkin AJ. Spore coat architecture of Clostridium novyi NT spores. Journal of Bacteriology. 189: 6457-68. PMID 17586633 DOI: 10.1128/Jb.00757-07  0.458
2007 Zhang X, Guo A, Yu J, Possemato A, Chen Y, Zheng W, Polakiewicz RD, Kinzler KW, Vogelstein B, Velculescu VE, Wang ZJ. Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. Proceedings of the National Academy of Sciences of the United States of America. 104: 4060-4. PMID 17360477 DOI: 10.1073/Pnas.0611665104  0.59
2007 Lagerstedt Robinson K, Liu T, Vandrovcova J, Halvarsson B, Clendenning M, Frebourg T, Papadopoulos N, Kinzler KW, Vogelstein B, Peltomäki P, Kolodner RD, Nilbert M, Lindblom A. Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics Journal of the National Cancer Institute. 99: 291-299. PMID 17312306 DOI: 10.1093/Jnci/Djk051  0.418
2007 Peters BA, St Croix B, Sjöblom T, Cummins JM, Silliman N, Ptak J, Saha S, Kinzler KW, Hatzis C, Velculescu VE. Large-scale identification of novel transcripts in the human genome. Genome Research. 17: 287-92. PMID 17267814 DOI: 10.1101/Gr.5486607  0.779
2007 Parmigiani G, Lin J, Boca SM, Sjöblom T, Jones S, Wood LD, Parsons DW, Barber T, Buckhaults P, Markowitz SD, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, et al. Response to comments on "The consensus coding sequences of human breast and colorectal cancers" Science. 317: 1500d. DOI: 10.1126/Science.1138773  0.331
2006 Cheong I, Huang X, Bettegowda C, Diaz LA, Kinzler KW, Zhou S, Vogelstein B. A bacterial protein enhances the release and efficacy of liposomal cancer drugs Science. 314: 1308-1311. PMID 17124324 DOI: 10.1126/Science.1130651  0.541
2006 Bettegowda C, Huang X, Lin J, Cheong I, Kohli M, Szabo SA, Zhang X, Diaz LA, Velculescu VE, Parmigiani G, Kinzler KW, Vogelstein B, Zhou S. The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT Nature Biotechnology. 24: 1573-1580. PMID 17115055 DOI: 10.1038/Nbt1256  0.685
2006 Chen S, Wang W, Lee S, Nafa K, Lee J, Romans K, Watson P, Gruber SB, Euhus D, Kinzler KW, Jass J, Gallinger S, Lindor NM, Casey G, Ellis N, et al. Prediction of germline mutations and cancer risk in the Lynch syndrome. Jama. 296: 1479-87. PMID 17003396 DOI: 10.1001/Jama.296.12.1479  0.352
2006 Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, ... ... Kinzler KW, et al. The consensus coding sequences of human breast and colorectal cancers Science. 314: 268-274. PMID 16959974 DOI: 10.1126/science.1133427  0.368
2006 Wood LD, Calhoun ES, Silliman N, Ptak J, Szabo S, Powell SM, Riggins GJ, Wang TL, Yan H, Gazdar A, Kern SE, Pennacchio L, Kinzler KW, Vogelstein B, Velculescu VE. Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers Human Mutation.. 27: 1060-1061. PMID 16941478 DOI: 10.1002/Humu.9452  0.461
2006 Papadopoulos N, Kinzler KW, Vogelstein B. The role of companion diagnostics in the development and use of mutation-targeted cancer therapies Nature Biotechnology. 24: 985-995. PMID 16900147 DOI: 10.1038/Nbt1234  0.409
2006 Nanda A, Karim B, Peng Z, Liu G, Qiu W, Gan C, Vogelstein B, Croix BS, Kinzler KW, Huso DL. Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors Proceedings of the National Academy of Sciences of the United States of America. 103: 3351-3356. PMID 16492758 DOI: 10.1073/Pnas.0511306103  0.732
2005 Diehl F, Li M, Dressman D, He Y, Shen D, Szabo S, Diaz LA, Goodman SN, David KA, Juhl H, Kinzler KW, Vogelstein B. Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proceedings of the National Academy of Sciences of the United States of America. 102: 16368-73. PMID 16258065 DOI: 10.1073/Pnas.0507904102  0.397
2005 Diaz LA, Cheong I, Foss CA, Zhang X, Peters BA, Agrawal N, Bettegowda C, Karim B, Liu G, Khan K, Huang X, Kohli M, Dang LH, Hwang P, Vogelstein A, ... ... Kinzler KW, et al. Pharmacologic and toxicologic evaluation of C. novyi-NT spores. Toxicological Sciences : An Official Journal of the Society of Toxicology. 88: 562-75. PMID 16162850 DOI: 10.1093/Toxsci/Kfi316  0.763
2005 Parsons DW, Wang TL, Samuels Y, Bardelli A, Cummins JM, DeLong L, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE. Colorectal cancer: mutations in a signalling pathway. Nature. 436: 792. PMID 16094359 DOI: 10.1038/436792A  0.39
2005 Smith AB, Freeze BS, LaMarche MJ, Sager J, Kinzler KW, Vogelstein B. Discodermolide analogues as the chemical component of combination bacteriolytic therapy. Bioorganic & Medicinal Chemistry Letters. 15: 3623-6. PMID 15979874 DOI: 10.1016/J.Bmcl.2005.05.068  0.377
2005 Bachman KE, Sager J, Cheong I, Catto M, Bardelli A, Park BH, Vogelstein B, Carotti A, Kinzler KW, Lengauer C. Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells Molecular Cancer Therapeutics. 4: 1026-1030. PMID 15956261 DOI: 10.1158/1535-7163.Mct-05-0038  0.34
2005 Samuels Y, Diaz LA, Schmidt-Kittler O, Cummins JM, Delong L, Cheong I, Rago C, Huso DL, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell. 7: 561-73. PMID 15950905 DOI: 10.1016/J.Ccr.2005.05.014  0.434
2005 Peters BA, Diaz LA, Polyak K, Meszler L, Romans K, Guinan EC, Antin JH, Myerson D, Hamilton SR, Vogelstein B, Kinzler KW, Lengauer C. Contribution of bone marrow-derived endothelial cells to human tumor vasculature Nature Medicine. 11: 261-262. PMID 15723071 DOI: 10.1038/Nm1200  0.692
2005 Bettegowda C, Foss CA, Cheong I, Wang Y, Diaz L, Agrawal N, Fox J, Dick J, Dang LH, Zhou S, Kinzler KW, Vogelstein B, Pomper MG. Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil. Proceedings of the National Academy of Sciences of the United States of America. 102: 1145-50. PMID 15653773 DOI: 10.1073/Pnas.0408861102  0.462
2004 Barber TD, Vogelstein B, Kinzler KW, Velculescu VE. Somatic mutations of EGFR in colorectal cancers and glioblastomas [6] New England Journal of Medicine. 351: 2883. PMID 15625347 DOI: 10.1056/Nejm200412303512724  0.39
2004 Nanda A, Buckhaults P, Seaman S, Agrawal N, Boutin P, Shankara S, Nacht M, Teicher B, Stampfl J, Singh S, Vogelstein B, Kinzler KW, St Croix B. Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R. Cancer Research. 64: 8507-11. PMID 15574754 DOI: 10.1158/0008-5472.Can-04-2716  0.728
2004 Kohli M, Yu J, Seaman C, Bardelli A, Kinzler KW, Vogelstein B, Lengauer C, Zhang L. SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells Proceedings of the National Academy of Sciences of the United States of America. 101: 16897-16902. PMID 15557007 DOI: 10.1073/Pnas.0403405101  0.305
2004 Agrawal N, Bettegowda C, Cheong I, Geschwind JF, Drake CG, Hipkiss EL, Tatsumi M, Dang LH, Diaz LA, Pomper M, Abusedera M, Wahl RL, Kinzler KW, Zhou S, Huso DL, et al. Bacteriolytic therapy can generate a potent immune response against experimental tumors Proceedings of the National Academy of Sciences of the United States of America. 101: 15172-15177. PMID 15471990 DOI: 10.1073/Pnas.0406242101  0.559
2004 Vogelstein B, Kinzler KW. Cancer genes and the pathways they control Nature Medicine. 10: 789-799. PMID 15286780 DOI: 10.1038/Nm1087  0.407
2004 Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, van der Heijden MS, Parmigiani G, Yan H, Wang TL, Riggins G, Powell SM, ... ... Kinzler KW, et al. Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science (New York, N.Y.). 304: 1164-6. PMID 15155950 DOI: 10.1126/Science.1096096  0.735
2004 Cummins JM, Kohli M, Rago C, Kinzler KW, Vogelstein B, Bunz F. X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells. Cancer Research. 64: 3006-8. PMID 15126334 DOI: 10.1158/0008-5472.Can-04-0046  0.364
2004 Wang Z, Cummins JM, Shen D, Cahill DP, Jallepalli PV, Wang TL, Parsons DW, Traverso G, Awad M, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz SD, Goldberg ML, ... ... Kinzler KW, et al. Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Research. 64: 2998-3001. PMID 15126332 DOI: 10.1158/0008-5472.Can-04-0587  0.41
2004 Koopmann J, Buckhaults P, Brown DA, Zahurak ML, Sato N, Fukushima N, Sokoll LJ, Chan DW, Yeo CJ, Hruban RH, Breit SN, Kinzler KW, Vogelstein B, Goggins M. Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 2386-92. PMID 15073115 DOI: 10.1158/1078-0432.Ccr-03-0165  0.348
2004 Wang TL, Diaz LA, Romans K, Bardelli A, Saha S, Galizia G, Choti M, Donehower R, Parmigiani G, Shih IM, Iacobuzio-Donahue C, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE. Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients Proceedings of the National Academy of Sciences of the United States of America. 101: 3089-3094. PMID 14970324 DOI: 10.1073/Pnas.0308716101  0.707
2004 Nanda A, Carson-Walter EB, Seaman S, Barber TD, Stampfl J, Singh S, Vogelstein B, Kinzler KW, St Croix B. TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI). Cancer Research. 64: 817-20. PMID 14871805 DOI: 10.1158/0008-5472.Can-03-2408  0.711
2004 Dang LH, Bettegowda C, Agrawal N, Cheong I, Huso D, Frost P, Loganzo F, Greenberger L, Barkoczy J, Pettit GR, Smith AB, Gurulingappa H, Khan S, Parmigiani G, Kinzler KW, et al. Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents Cancer Biology and Therapy. 3: 326-337. PMID 14739784 DOI: 10.4161/Cbt.3.3.704  0.542
2004 Kohli M, Rago C, Lengauer C, Kinzler KW, Vogelstein B. Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses Nucleic Acids Research. 32: e3. PMID 14704360 DOI: 10.1093/Nar/Gnh009  0.371
2003 Traverso G, Bettegowda C, Kraus J, Speicher MR, Kinzler KW, Vogelstein B, Lengauer C. Hyper-Recombination and Genetic Instability in BLM-Deficient Epithelial Cells Cancer Research. 63: 8578-8581. PMID 14695165  0.522
2003 Bettegowda C, Dang LH, Abrams R, Huso DL, Dillehay L, Cheong I, Agrawal N, Borzillary S, McCaffery JM, Watson EL, Lin KS, Bunz F, Baidoo K, Pomper MG, Kinzler KW, et al. Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria. Proceedings of the National Academy of Sciences of the United States of America. 100: 15083-8. PMID 14657371 DOI: 10.1073/Pnas.2036598100  0.498
2003 Bardelli A, Saha S, Sager JA, Romans KE, Xin B, Markowitz SD, Lengauer C, Velculescu VE, Kinzler KW, Vogelstein B. PRL-3 Expression in Metastatic Cancers Clinical Cancer Research. 9: 5607-5615. PMID 14654542  0.695
2003 Bardelli A, Parsons DW, Silliman N, Ptak J, Szabo S, Saha S, Markowitz S, Willson JKV, Parmigiani G, Kinzler KW, Vogelstein B, Velculescu VE. Mutational analysis of the tyrosine kinome in colorectal cancers Science. 300: 949. PMID 12738854 DOI: 10.1126/Science.1082596  0.701
2003 Yu J, Wang Z, Kinzler KW, Vogelstein B, Zhang L. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 1931-6. PMID 12574499 DOI: 10.1073/Pnas.2627984100  0.353
2003 Bachman KE, Park BH, Rhee I, Rajagopalan H, Herman JG, Baylin SB, Kinzler KW, Vogelstein B. Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene Cancer Cell. 3: 89-95. PMID 12559178 DOI: 10.1016/S1535-6108(02)00234-9  0.762
2002 Wang TL, Maierhofer C, Speicher MR, Lengauer C, Vogelstein B, Kinzler KW, Velculescu VE. Digital karyotyping. Proceedings of the National Academy of Sciences of the United States of America. 99: 16156-61. PMID 12461184 DOI: 10.1073/Pnas.202610899  0.357
2002 Saha S, Sparks AB, Rago C, Akmaev V, Wang CJ, Vogelstein B, Kinzler KW, Velculescu VE. Using the transcriptome to annotate the genome. Nature Biotechnology. 20: 508-12. PMID 11981567 DOI: 10.1038/Nbt0502-508  0.664
2002 Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, Vogelstein B. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature. 416: 552-6. PMID 11932749 DOI: 10.1038/416552A  0.79
2002 Wang TL, Rago C, Silliman N, Ptak J, Markowitz S, Willson JK, Parmigiani G, Kinzler KW, Vogelstein B, Velculescu VE. Prevalence of somatic alterations in the colorectal cancer cell genome. Proceedings of the National Academy of Sciences of the United States of America. 99: 3076-80. PMID 11867767 DOI: 10.1073/Pnas.261714699  0.478
2002 Traverso G, Shuber A, Olsson L, Levin B, Johnson C, Hamilton SR, Boynton K, Kinzler KW, Vogelstein B. Detection of proximal colorectal cancers through analysis of faecal DNA. Lancet (London, England). 359: 403-4. PMID 11844514 DOI: 10.1016/S0140-6736(02)07591-8  0.398
2002 Yan H, Dobbie Z, Gruber SB, Markowitz S, Romans K, Giardiello FM, Kinzler KW, Vogelstein B. Small changes in expression affect predisposition to tumorigenesis Nature Genetics. 30: 25-26. PMID 11743581 DOI: 10.1038/Ng799  0.346
2001 Dang LH, Bettegowda C, Huso DL, Kinzler KW, Vogelstein B. Combination bacteriolytic therapy for the treatment of experimental tumors. Proceedings of the National Academy of Sciences of the United States of America. 98: 15155-60. PMID 11724950 DOI: 10.1073/Pnas.251543698  0.557
2001 Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St Croix B, Romans KE, Choti MA, Lengauer C, Kinzler KW, Vogelstein B. A phosphatase associated with metastasis of colorectal cancer. Science (New York, N.Y.). 294: 1343-6. PMID 11598267 DOI: 10.1126/Science.1065817  0.734
2001 Buckhaults P, Rago C, St Croix B, Romans KE, Saha S, Zhang L, Vogelstein B, Kinzler KW. Secreted and cell surface genes expressed in benign and malignant colorectal tumors. Cancer Research. 61: 6996-7001. PMID 11585723  0.698
2001 Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B. Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Research. 61: 6649-55. PMID 11559528  0.726
2001 Vogelstein B, Kinzler KW. Achilles' heel of cancer? Nature. 412: 865-6. PMID 11528457 DOI: 10.1038/35091170  0.345
2001 Dong SM, Traverso G, Johnson C, Geng L, Favis R, Boynton K, Hibi K, Goodman SN, D'Allessio M, Paty P, Hamilton SR, Sidransky D, Barany F, Levin B, Shuber A, ... Kinzler KW, et al. Detecting colorectal cancer in stool with the use of multiple genetic targets. Journal of the National Cancer Institute. 93: 858-65. PMID 11390535 DOI: 10.1093/Jnci/93.11.858  0.365
2001 Bardelli A, Cahill DP, Lederer G, Speicher MR, Kinzler KW, Vogelstein B, Lengauer C. Carcinogen-specific induction of genetic instability. Proceedings of the National Academy of Sciences of the United States of America. 98: 5770-5. PMID 11296254 DOI: 10.1073/Pnas.081082898  0.327
2001 Thiagalingam S, Laken S, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B, Lengauer C. Mechanisms underlying losses of heterozygosity in human colorectal cancers. Proceedings of the National Academy of Sciences of the United States of America. 98: 2698-702. PMID 11226302 DOI: 10.1073/Pnas.051625398  0.342
2001 Shih IM, Wang TL, Traverso G, Romans K, Hamilton SR, Ben-Sasson S, Kinzler KW, Vogelstein B. Top-down morphogenesis of colorectal tumors. Proceedings of the National Academy of Sciences of the United States of America. 98: 2640-5. PMID 11226292 DOI: 10.1073/Pnas.051629398  0.354
2001 Park BH, Vogelstein B, Kinzler KW. Genetic disruption of PPARδ decreases the tumorigenicity of human colon cancer cells Proceedings of the National Academy of Sciences of the United States of America. 98: 2598-2603. PMID 11226285 DOI: 10.1073/Pnas.051630998  0.403
2001 Zhou W, Galizia G, Lieto E, Goodman SN, Romans KE, Kinzler KW, Vogelstein B, Choti MA, Montgomery EA. Counting alleles reveals a connection between chromosome 18q loss and vascular invasion. Nature Biotechnology. 19: 78-81. PMID 11135558 DOI: 10.1038/83572  0.373
2001 Hwang PM, Bunz F, Yu J, Rago C, Chan TA, Murphy MP, Kelso GF, Smith RAJ, Kinzler KW, Vogelstein B. Erratum: Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells (Nature Medicine (2001) 7 (1111-1117)) Nature Medicine. 7. DOI: 10.1038/Nm1101-1255A  0.326
2000 St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW. Genes expressed in human tumor endothelium. Science (New York, N.Y.). 289: 1197-202. PMID 10947988 DOI: 10.1126/Science.289.5482.1197  0.383
2000 Chan TA, Hwang PM, Hermeking H, Kinzler KW, Vogelstein B. Cooperative effects of genes controlling the G(2)/M checkpoint. Genes & Development. 14: 1584-8. PMID 10887152 DOI: 10.1101/Gad.14.13.1584  0.328
2000 Rhee I, Jair KW, Yen RW, Lengauer C, Herman JG, Kinzler KW, Vogelstein B, Baylin SB, Schuebel KE. CpG methylation is maintained in human cancer cells lacking DNMT1. Nature. 404: 1003-7. PMID 10801130 DOI: 10.1038/35010000  0.784
1999 Yu J, Zhang L, Hwang PM, Rago C, Kinzler KW, Vogelstein B. Identification and classification of p53-regulated genes. Proceedings of the National Academy of Sciences of the United States of America. 96: 14517-22. PMID 10588737 DOI: 10.1073/Pnas.96.25.14517  0.35
1999 He TC, Chan TA, Vogelstein B, Kinzler KW. PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell. 99: 335-45. PMID 10555149 DOI: 10.1016/S0092-8674(00)81664-5  0.354
1999 Da Costa LT, He TC, Yu J, Sparks AB, Morin PJ, Polyak K, Laken S, Vogelstein B, Kinzler KW. CDX2 is mutated in a colorectal cancer with normal APC/β-catenin signaling Oncogene. 18: 5010-5014. PMID 10490837 DOI: 10.1038/Sj.Onc.1202872  0.413
1999 Vogelstein B, Kinzler KW. Digital PCR. Proceedings of the National Academy of Sciences of the United States of America. 96: 9236-41. PMID 10430926 DOI: 10.1073/Pnas.96.16.9236  0.356
1999 Bunz F, Hwang PM, Torrance C, Waldman T, Zhang Y, Dillehay L, Williams J, Lengauer C, Kinzler KW, Vogelstein B. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. The Journal of Clinical Investigation. 104: 263-9. PMID 10430607 DOI: 10.1172/Jci6863  0.35
1999 Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B, Lengauer C. Characterization of MAD2B and other mitotic spindle checkpoint genes. Genomics. 58: 181-7. PMID 10366450 DOI: 10.1006/Geno.1999.5831  0.309
1999 Laken SJ, Papadopoulos N, Petersen GM, Gruber SB, Hamilton SR, Giardiello FM, Brensinger JD, Vogelstein B, Kinzler KW. Analysis of masked mutations in familial adenomatous polyposis Proceedings of the National Academy of Sciences of the United States of America. 96: 2322-2326. PMID 10051640 DOI: 10.1073/Pnas.96.5.2322  0.361
1999 Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature. 396: 643-9. PMID 9872311 DOI: 10.1038/25292  0.342
1998 Polyak K, Li Y, Zhu H, Lengauer C, Willson JK, Markowitz SD, Trush MA, Kinzler KW, Vogelstein B. Somatic mutations of the mitochondrial genome in human colorectal tumours. Nature Genetics. 20: 291-3. PMID 9806551 DOI: 10.1038/3108  0.392
1998 He TC, Sparks AB, Rago C, Hermeking H, Zawel L, Da Costa LT, Morin PJ, Vogelstein B, Kinzler KW. Identification of c-MYC as a target of the APC pathway Science. 281: 1509-1512. PMID 9727977 DOI: 10.1126/Science.281.5382.1509  0.401
1998 Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JPJ, Markowitz S, Willson JKV, Hamilton SR, Kinzler KW, Kane MF, Kolodner RD, Vogelstein B, Kunkel TA, Baylin SB. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma Proceedings of the National Academy of Sciences of the United States of America. 95: 6870-6875. PMID 9618505 DOI: 10.1073/Pnas.95.12.6870  0.426
1998 Kinzler KW, Vogelstein B. Landscaping the cancer terrain. Science (New York, N.Y.). 280: 1036-7. PMID 9616081 DOI: 10.1126/Science.280.5366.1036  0.39
1998 Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B. Mutations of mitotic checkpoint genes in human cancers. Nature. 392: 300-3. PMID 9521327 DOI: 10.1038/32688  0.413
1998 Nicolaides NC, Littman SJ, Modrich P, Kinzler KW, Vogelstein B. A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype Molecular and Cellular Biology. 18: 1635-1641. PMID 9488480 DOI: 10.1128/Mcb.18.3.1635  0.414
1998 Zhou S, Buckhaults P, Zawel L, Bunz F, Riggins G, Dai JL, Kern SE, Kinzler KW, Vogelstein B. Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 2412-6. PMID 9482899 DOI: 10.1073/Pnas.95.5.2412  0.323
1998 Chan TA, Morin PJ, Vogelstein B, Kinzler KW. Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 95: 681-6. PMID 9435252 DOI: 10.1073/Pnas.95.2.681  0.349
1997 Waldman T, Zhang Y, Dillehay L, Yu J, Kinzler K, Vogelstein B, Williams J. Cell-cycle arrest versus cell death in cancer therapy. Nature Medicine. 3: 1034-6. PMID 9288734 DOI: 10.1038/Nm0997-1034  0.38
1997 Laken SJ, Petersen GM, Gruber SB, Oddoux C, Ostrer H, Giardiello FM, Hamilton SR, Hampel H, Markowitz A, Klimstra D, Jhanwar S, Winawer S, Offit K, Luce MC, Kinzler KW, et al. Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC Nature Genetics. 17: 79-83. PMID 9288102 DOI: 10.1038/Ng0997-79  0.392
1997 Giardiello FM, Petersen GM, Piantadosi S, Gruber SB, Traboulsi EI, Offerhaus GJA, Muro K, Krush AJ, Booker SV, Luce MC, Laken SJ, Kinzler KW, Vogelstein B, Hamilton SR. APC gene mutations and extraintestinal phenotype of familial adenomatous polyposis Gut. 40: 521-525. PMID 9176082 DOI: 10.1136/Gut.40.4.521  0.383
1997 Kinzler KW, Vogelstein B. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature. 386: 761, 763. PMID 9126728 DOI: 10.1038/386761A0  0.377
1997 Lengauer C, Kinzler KW, Vogelstein B. DNA methylation and genetic instability in colorectal cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 2545-50. PMID 9122232 DOI: 10.1073/Pnas.94.6.2545  0.366
1997 Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature. 386: 623-7. PMID 9121588 DOI: 10.1038/386623A0  0.303
1997 Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, Kinzler KW. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC Science. 275: 1787-1790. PMID 9065402 DOI: 10.1126/Science.275.5307.1787  0.376
1997 Korinek V, Barker N, Morin PJ, Van Wichen D, De Weger R, Kinzler KW, Vogelstein B, Clevers H. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC(-/-) colon carcinoma Science. 275: 1784-1787. PMID 9065401 DOI: 10.1126/Science.275.5307.1784  0.302
1997 Dunlop MG, Farrington SM, Carothers AD, Wyllie AH, Sharp L, Burn J, Liu B, Kinzler KW, Vogelstein B. Cancer risk associated with germline DNA mismatch repair gene mutations. Human Molecular Genetics. 6: 105-10. PMID 9002677 DOI: 10.1093/Hmg/6.1.105  0.389
1997 Nicolaides NC, Palombo F, Kinzler KW, Vogelstein B, Jiricny J. Molecular cloning of the N-terminus of GTBP. Genomics. 31: 395-7. PMID 8838326 DOI: 10.1006/Geno.1996.0067  0.394
1996 Huang J, Papadopoulos N, McKinley AJ, Farrington SM, Curtis LJ, Wyllie AH, Zheng S, Willson JK, Markowitz SD, Morin P, Kinzler KW, Vogelstein B, Dunlop MG. APC mutations in colorectal tumors with mismatch repair deficiency. Proceedings of the National Academy of Sciences of the United States of America. 93: 9049-54. PMID 8799152 DOI: 10.1073/Pnas.93.17.9049  0.423
1996 Beazer-Barclay Y, Levy DB, Moser AR, Dove WF, Hamilton SR, Vogelstein B, Kinzler KW. Sulindac suppresses tumorigenesis in the Min mouse. Carcinogenesis. 17: 1757-60. PMID 8761438 DOI: 10.1093/Carcin/17.8.1757  0.318
1996 Morin PJ, Vogelstein B, Kinzler KW. Apoptosis and APC in colorectal tumorigenesis Proceedings of the National Academy of Sciences of the United States of America. 93: 7950-7954. PMID 8755583 DOI: 10.1073/Pnas.93.15.7950  0.439
1996 Pietenpol JA, Lengauer C, Jordan J, Kinzler KW, Vogelstein B. Mammalian cells resistant to tumor suppressor genes Proceedings of the National Academy of Sciences of the United States of America. 93: 8390-8394. PMID 8710881 DOI: 10.1073/Pnas.93.16.8390  0.315
1996 Thiagalingam S, Lengauer C, Leach FS, Schutte M, Hahn SA, Overhauser J, Willson JK, Markowitz S, Hamilton SR, Kern SE, Kinzler KW, Vogelstein B. Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nature Genetics. 13: 343-6. PMID 8673134 DOI: 10.1038/Ng0796-343  0.37
1996 Nicolaides NC, Kinzler KW, Vogelstein B. Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene. Genomics. 29: 329-34. PMID 8666379 DOI: 10.1006/Geno.1995.9997  0.38
1996 Da Costa LT, Jen J, He TC, Chan TA, Kinzler KW, Vogelstein B. Converting cancer genes into killer genes. Proceedings of the National Academy of Sciences of the United States of America. 93: 4192-6. PMID 8633039 DOI: 10.1073/Pnas.93.9.4192  0.389
1996 Nicolaides NC, Carter KC, Shell BK, Papadopoulos N, Vogelstein B, Kinzler KW. Genomic organization of the human PMS2 gene family. Genomics. 30: 195-206. PMID 8586419 DOI: 10.1006/Geno.1995.9885  0.353
1996 Liu B, Parsons R, Papadopoulos N, Nicolaides NC, Lynch HT, Watson P, Jass JR, Dunlop M, Wyllie A, Peltomäki P, de la Chapelle A, Hamilton SR, Vogelstein B, Kinzler KW. Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nature Medicine. 2: 169-74. PMID 8574961 DOI: 10.1038/Nm0296-169  0.435
1996 Kinzler KW, Vogelstein B. Life (and death) in a malignant tumour. Nature. 379: 19-20. PMID 8538735 DOI: 10.1038/379019A0  0.317
1995 Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science (New York, N.Y.). 268: 1336-8. PMID 7761852 DOI: 10.1126/Science.7761852  0.361
1995 Liu B, Nicolaides NC, Markowitz S, Willson JKV, Parsons RE, Jen J, Papadopolous N, Peltomäki P, de la Chapelle A, Hamilton SR, Kinzler KW, Vogelstein B. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability Nature Genetics. 9: 48-55. PMID 7704024 DOI: 10.1038/Ng0195-48  0.414
1995 Hamilton SR, Parsons RE, Papadopoulos N, Jen J, Powell SM, Krush AJ, Berk T, Cohen Z, Tetu B, Burger PC, Wood PA, Taqi F, Booker SV, Petersen GM, Offerhaus GJA, ... ... Kinzler KW, et al. The molecular basis of Turcot's syndrome New England Journal of Medicine. 332: 839-847. PMID 7661930 DOI: 10.1056/Nejm199503303321302  0.393
1995 Parsons R, Li GM, Longley M, Modrich P, Liu B, Berk T, Hamilton SR, Kinzler KW, Vogelstein B. Mismatch repair deficiency in phenotypically normal human cells Science. 268: 738-740. PMID 7632227 DOI: 10.1126/Science.7632227  0.418
1995 Papadopoulos N, Nicolaides NC, Liu B, Parsons R, Lengauer C, Palombo F, D'Arrigo A, Markowitz S, Willson JK, Kinzler KW. Mutations of GTBP in genetically unstable cells. Science (New York, N.Y.). 268: 1915-7. PMID 7604266 DOI: 10.1126/Science.7604266  0.412
1995 Thiagalingam S, Kinzler KW, Vogelstein B. PAK1, a gene that can regulate p53 activity in yeast. Proceedings of the National Academy of Sciences of the United States of America. 92: 6062-6. PMID 7597081 DOI: 10.1073/Pnas.92.13.6062  0.341
1995 Vogelstein B, Kinzler KW. Colorectal cancer and the intersection between basic and clinical research. Cold Spring Harbor Symposia On Quantitative Biology. 59: 517-21. PMID 7587107 DOI: 10.1101/Sqb.1994.059.01.057  0.312
1995 Liu B, Farrington SM, Petersen GM, Hamilton SR, Parsons R, Papadopoulos N, Fujiwara T, Jen J, Kinzler KW, Wyllie AH, Vogelstein B, Dunlop MG. Genetic instability occurs in the majority of young patients with colorectal cancer. Nature Medicine. 1: 348-52. PMID 7585065 DOI: 10.1038/Nm0495-348  0.354
1994 Parsons R, Li GM, Longley MJ, Fang WH, Papadopoulos N, Jen J, de la Chapelle A, Kinzler KW, Vogelstein B, Modrich P. Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell. 75: 1227-36. PMID 8261516 DOI: 10.1016/0092-8674(93)90331-J  0.428
1994 Su LK, Vogelstein B, Kinzler KW. Association of the APC tumor suppressor protein with catenins. Science (New York, N.Y.). 262: 1734-7. PMID 8259519 DOI: 10.1126/Science.8259519  0.413
1994 Kinzler KW, Vogelstein B. Cancer therapy meets p53. The New England Journal of Medicine. 331: 49-50. PMID 8202105 DOI: 10.1056/Nejm199407073310113  0.352
1994 Pietenpol JA, Tokino T, Thiagalingam S, El-Deiry WS, Kinzler KW, Vogelstein B. Sequence-specific transcriptional activation is essential for growth suppression by p53 Proceedings of the National Academy of Sciences of the United States of America. 91: 1998-2002. PMID 8134338 DOI: 10.1073/Pnas.91.6.1998  0.355
1994 Papadopoulos N, Nicolaides NC, Wei YF, Ruben SM, Carter KC, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD, Venter JC, Hamilton SR, Petersen GM, Watson P, Lynch HT, ... ... Kinzler KW, et al. Mutation of a mutL homolog in hereditary colon cancer Science. 263: 1625-1629. PMID 8128251 DOI: 10.1126/Science.8128251  0.419
1994 Jen J, Kim H, Piantadosi S, Liu ZF, Levitt RC, Sistonen P, Kinzler KW, Vogelstein B, Hamilton SR. Allelic loss of chromosome 18q and prognosis in colorectal cancer. The New England Journal of Medicine. 331: 213-21. PMID 8015568 DOI: 10.1056/Nejm199407283310401  0.354
1994 Powell SM, Papadopoulos N, Kinzler KW, Smolinski KN, Meltzer SJ. APC gene mutations in the mutation cluster region are rare in esophageal cancers. Gastroenterology. 107: 1759-63. PMID 7958689 DOI: 10.1016/0016-5085(94)90818-4  0.427
1994 Hedrick L, Cho KR, Fearon ER, Wu TC, Kinzler KW, Vogelstein B. The DCC gene product in cellular differentiation and colorectal tumorigenesis. Genes & Development. 8: 1174-83. PMID 7926722 DOI: 10.1101/Gad.8.10.1174  0.408
1994 Vogelstein B, Kinzler KW. Has the breast cancer gene been found? Cell. 79: 1-3. PMID 7923368 DOI: 10.1016/0092-8674(94)90393-X  0.318
1993 Vogelstein B, Kinzler KW. The multistep nature of cancer. Trends in Genetics : Tig. 9: 138-41. PMID 8516849 DOI: 10.1016/0168-9525(93)90209-Z  0.414
1993 Kinzler KW, Vogelstein B. Cancer. A gene for neurofibromatosis 2. Nature. 363: 495-6. PMID 8505975 DOI: 10.1038/363495A0  0.382
1993 Petersen GM, Francomano C, Kinzler K, Nakamura Y. Presymptomatic direct detection of adenomatous polyposis coli (APC) gene mutations in familial adenomatous polyposis Human Genetics. 91: 307-311. PMID 8388848 DOI: 10.1007/Bf00217347  0.334
1993 Luongo C, Gould KA, Su LK, Kinzler KW, Vogelstein B, Dietrich W, Lander ES, Moser AR. Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse. Genomics. 15: 3-8. PMID 8094372 DOI: 10.1006/Geno.1993.1002  0.366
1993 Simons JW, Oliner JD, Cho KR, Kinzler KW, Vogelstein B. SAM 1.1 and JOSH 4.4: two RFLPs within the human DCC gene. Human Molecular Genetics. 1: 352. PMID 1363875 DOI: 10.1093/Hmg/1.5.352  0.304
1993 Nakamura Y, Nishisho I, Kinzler KW, Vogelstein B, Miyoshi Y, Miki Y, Ando H, Horii A. Mutations of the APC (adenomatous polyposis coli) gene in FAP (familial polyposis coli) patients and in sporadic colorectal tumors. The Tohoku Journal of Experimental Medicine. 168: 141-7. PMID 1339098 DOI: 10.1620/Tjem.168.141  0.336
1992 Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature. 358: 80-3. PMID 1614537 DOI: 10.1038/358080A0  0.365
1992 Kern SE, Pietenpol JA, Thiagalingam S, Seymour A, Kinzler KW, Vogelstein B. Oncogenic forms of p53 inhibit p53-regulated gene expression Science. 256: 827-830. PMID 1589764 DOI: 10.1126/Science.1589764  0.342
1992 Sidransky D, Tokino T, Hamilton SR, Kinzler KW, Levin B, Frost P, Vogelstein B. Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. Science (New York, N.Y.). 256: 102-5. PMID 1566048 DOI: 10.1126/Science.1566048  0.404
1992 Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, Vogelstein B, Kinzler KW. APC mutations occur early during colorectal tumorigenesis. Nature. 359: 235-7. PMID 1528264 DOI: 10.1038/359235A0  0.397
1992 Su LK, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, Luongo C, Gould KA, Dove WF. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science (New York, N.Y.). 256: 668-70. PMID 1350108 DOI: 10.1126/Science.1350108  0.432
1992 Miyoshi Y, Nishisho I, Miki Y, Mori T, Kinzler KW, Vogelstein B, Nakamura Y. Insertion/deletion polymorphism and other restriction fragment length polymorphisms in the MCC gene. Japanese Journal of Cancer Research : Gann. 83: 10-4. PMID 1347524 DOI: 10.1111/J.1349-7006.1992.Tb02344.X  0.349
1992 Kinzler KW, Vogelstein B. The colorectal cancer gene hunt: current findings. Hospital Practice (Office Ed.). 27: 51-8. PMID 1331139 DOI: 10.1080/21548331.1992.11705522  0.418
1992 Su L, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, Luongo C, Gould KA, Dove WF. Corrections and Clarifications: Multiple Intestinal Neoplasia Caused By a Mutation in the Murine Homolog of the APC Gene Science. 256: 1114-1114. DOI: 10.1126/Science.256.5060.1114-C  0.359
1991 Kinzler KW, Nilbert MC, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hamilton SR, Hedge P, Markham A. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science (New York, N.Y.). 251: 1366-70. PMID 1848370 DOI: 10.1126/Science.1848370  0.452
1991 Ruppert JM, Vogelstein B, Kinzler KW. The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A. Molecular and Cellular Biology. 11: 1724-8. PMID 1825351 DOI: 10.1128/Mcb.11.3.1724  0.304
1991 Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, Horii A, Koyama K, Utsunomiya J, Baba S, Hedge P, Markham A, Krush AJ, Petersen G, Hamilton SR, Nilbert MC, ... ... Kinzler KW, et al. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients Science. 253: 665-669. PMID 1651563 DOI: 10.1126/Science.1651563  0.426
1990 Fearon ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, Hamilton SR, Preisinger AC, Thomas G, Kinzler KW. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science (New York, N.Y.). 247: 49-56. PMID 2294591 DOI: 10.1126/Science.2294591  0.421
1990 Ruppert JM, Vogelstein B, Arheden K, Kinzler KW. GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. Molecular and Cellular Biology. 10: 5408-15. PMID 2118997 DOI: 10.1128/Mcb.10.10.5408  0.324
1990 Kinzler KW, Vogelstein B. The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Molecular and Cellular Biology. 10: 634-42. PMID 2105456 DOI: 10.1128/Mcb.10.2.634  0.316
1987 Kinzler KW, Bigner SH, Bigner DD, Trent JM, Law ML, O'Brien SJ, Wong AJ, Vogelstein B. Identification of an amplified, highly expressed gene in a human glioma. Science (New York, N.Y.). 236: 70-3. PMID 3563490 DOI: 10.1126/Science.3563490  0.377
1987 Wong AJ, Bigner SH, Bigner DD, Kinzler KW, Hamilton SR, Vogelstein B. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proceedings of the National Academy of Sciences of the United States of America. 84: 6899-903. PMID 3477813 DOI: 10.1073/Pnas.84.19.6899  0.371
1987 Bigner S, Wong A, Mark J, Kinzler K, Vogelstein B, Bigner D. 13 Chromosomes and gene amplification in malignant human gliomas (MHG) Cancer Genetics and Cytogenetics. 28: 32. DOI: 10.1016/0165-4608(87)90292-5  0.302
1986 Kinzler KW, Zehnbauer BA, Brodeur GM, Seeger RC, Trent JM, Meltzer PS, Vogelstein B. Amplification units containing human N-myc and c-myc genes Proceedings of the National Academy of Sciences of the United States of America. 83: 1031-1035. PMID 3006024 DOI: 10.1073/Pnas.83.4.1031  0.341
1986 Trent J, Meltzer P, Rosenblum M, Harsh G, Kinzler K, Mashal R, Feinberg A, Vogelstein B. Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma Proceedings of the National Academy of Sciences of the United States of America. 83: 470-473. PMID 3001737 DOI: 10.1073/Pnas.83.2.470  0.387
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