1973 — 1976 |
Pecora, Robert |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Thermal Motions in Liquid and Polymer Systems |
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1976 — 1992 |
Pecora, Robert |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Theoretical and Experimental Studies of Thermal Motions in Liquids and Polymer Systems
Professor Robert Pecora is supported by a grant from The Experimental Physical Chemistry Program to continue his theoretical and experimental studies of the dynamics of molecules in complex liquid systems. Professor Pecora is studying the motions of polymeric materials, oligonucleotides, and DNA restriction fragments. The main areas of complex liquids to be studied over the next three year period include: 1) reorientation, translation,and structure of small rodlike molecules both in solution with similarly sized solvent molecules and mixed with polymeric materials. Particular systems include solutions of a homologous series of double helical oligonucleotides, and motion of a series of rodlike probes in amorphous and glassy polymethylmethacrolate. 2) dynamics of single semirigid rodlike polymer chains including theoretical and experimental studies of a homologous series of monodisperse DNA restriction fragments prepared using genetic engineering techniques. 3) motions of rigid and semirigid molecules in nondilute solutions including studies of oligonucleotides and DNA restriction fragments and ternary solutions containing solvent, and rodlike macromolecules mixed with either coils or coated silica spheres. A broad range of experimental techniques are used in these experiments including: transient electric birefringence, light scattering, interferometry, photon correlation spectroscopy, and force Rayleigh scattering. Theoretical techniques include both analytical modeling and computer simulations.
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1978 — 1981 |
Pecora, Robert |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Statistical Mechanics of Condensed Phases |
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1982 — 1986 |
Pecora, Robert |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Theoretical and Experimental Studies of Thermal Motions in Liquids and Polymer Systems (Chemistry) |
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1985 |
Pecora, Robert |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Dynamic Light Scattering From Biological Systems
The major research objective is to develop the dynamic light scattering technique and to apply it to the study of some important biological systems. Two main areas application will be pursued: (1) The dynamics, structure and interaction of long rigid and semi-rigid rod-shaped biomacromolecules in solution and (2) The morphology and growth kinetics of some self-assembling systems, mainly surfactant micelles and phospholipid vesicles. The first area of application includes studies of the flexibility and hydrodynamic size of the myosin molecules from rabbit muscle and the amoeba Dictyostelium, the intramolecular relaxation modes of Lambda-phage DNA, and the interactions of rods (mainly short fragments of DNA) in solutions including the semi-dilute region, and also the low salt region in which there is evidence that extraordinary phases exist. The flexibility and solution interactions of another muscle protein, F-actin will also be investigated. Theoretical models for these systems will be constructed and used to aid in the interpretation of the experiments. In the second category, the morphology of phospholipid vesicles will be studied by a depolarized total intensity technique and the kinetics of vesicle fusion will be followed using a newly-developed inverse Laplace transform data analysis technique. Sphere-to-rod transitions in surfactant micelle systems will be followed using both polarized and depolarized, dynamic light scattering.
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1991 — 1995 |
Pecora, Robert Homsy, George (co-PI) [⬀] Mcconnell, Harden (co-PI) [⬀] |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Arfmp: Renovation of Stauffer Chemistry, Chemical Engineering Complex
This Academic Research Facilities Modernization Program (ARFMP) award from the Research Facilities Office provides funds to Stanford University for the renovation and repair of the Stauffer building complex which houses a portion of the research and research training activities in Chemistry and Chemical Engineering. This building was constructed in 1961 and last renovated in 1989. The ARFMP grant of $1,500,000 and $4,375,000 provided by the grantee as cost sharing will be used to modernize these research and research training facilities so as to meet the significant new demands placed on them by research in these fields and the requirements for the safe practice of that research. This project will address the need to improve the current research infrastructure by systematically upgrading major building systems and by selectively renovating individual laboratories to conform to recent building and fire codes. Top priority will be given to the renovation of the intake/exhaust systems including the replacement of all existing fume hoods for safety, economic, and research quality considerations. This award contributes to the infrastructure of science and engineering by providing an improved environment for the conduct of research and for the training of quality undergraduate and graduate students. This project will enable two leading research and research training departments to continue to provide not only an outstanding environment but one with an increased capacity for training the excellent students it attracts. Students trained in these laboratories are in demand in both basic and applied research fields.
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1992 — 1995 |
Pecora, Robert |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Experimental and Theoretical Studies of Thermal Motions in Liquids and Polymer Systems
Professor Robert Pecora is supported by a grant from the Theoretical and Computational Chemistry Program to perform theoretical and experimental research on thermal motions in liquid and polymer systems. Professor Pecora will emply a number of experimental methods including interferometry, photon correlation spectroscopy, forced Rayleigh scattering and transient electric birefringence to study dilute and non-dilute solutions of rigid and semi-rigid rod-like molecules. He will also study composite solutions consisting of various combinations of rods, spheres, and coils. Some of the rod-like molecules he will study are DNA restriction fragments. The theoretical effort will involve both formal theoretical modeling and Brownian dynamics computer simulations. %%% Composite liquids are a ubiquitous class of materials which contain polymer, particles and solvent. They are used as ceramic precursors, lubricants, paints and coatings, adhesives, and in chromatographic columns. Due to their complexity and the lack of adequate model systems, the interactions between the species in such systems are not well understood. Pecora has constructed a model rod/sphere composite liquid whose dynamics can be studied over a wide range of composition of both the rods and the spheres using an experimental technique known as dynamic light scattering.
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1994 — 1995 |
Pecora, Robert |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Computer Workstations For Chemical Theory and Experiment
This award from the Chemistry Research Instrumentation Facilities Program will assist the Department of Chemistry at Stanford University in the purchase of an upgrade of their computational facility using DEC Workstations. This equipment will enhance research in a number of areas including the following: (1) Dynamics and Structure in Complex Molecular Systems, (2) High Performance Computing for Biophysical Spectroscopy, (3) Electronic Structures of Active Sites, (4) Chemical Reactions Far From Equilibrium, (5) Molecular Dynamics Computer Simulations, and (6) Theoretical and Computational X-ray Absorption Spectroscopy. A workstation network of fast, modern computer workstations is a new way to satisfy the computing needs of chemistry departments. Such a "computer network" also serves as a development environment for new theoretical codes and algorithms, and provides state-of-the-art graphics and visualization facilities.
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1994 — 1995 |
Pecora, Robert |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Purchase of 600 Mhz High Resolution Nmr
This award from the Chemistry Research Instrumentation Facilities Program will help the Department of Chemistry at Stanford University acquire a 500 MHz NMR spectrometer and solid state accessories to be used to upgrade the existing 400 MHz NMR spectrometer which will be used in research. The research activities to be supported include: (1) studies on the molecular basis of carcinogenesis, solution structures of peptide receptors, the synthesis and mode of action of DNA cleaving agents, the synthesis of taxol analogues and studies on their mode of action, mechanistic and synthetic organometallic chemistry, and mechanistic and synthetic photochemistry, (2) stereochemistry and mechanism of organometallic reactions in polymer synthesis and catalysis, (3) new approaches for synthetic efficiency, (4) mechanistic enzymology of oxidosqualene cyclization, (5) Coenzyme A Analogs as Probes of Enzymatic Reaction Mechanisms, and (6) Theoretical and Computational X-ray Absorption Spectroscopy. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers and catalysis, and in biology.
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1995 — 1999 |
Pecora, Robert |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Studies of Thermal Motions in Liquids and Polymer Systems
Robert Pecora is supported by a grant from the Theoretical and Computational Chemistry Program to continue his research involving motions in liquid and polymer systems. A variety of light scattering techniques are used such as Fabry-Perot interferometry and photocorrelation spectroscopy as well as total intensity light scattering and transient electric birefringence decay. The dynamics of both dilute and nondilute solutions of rigid and semirigid rodlike molecules including polypeptides, collagen, small rodlike protein, oligonucleotides, and DNA fragments will be studied. The effect of interaction and entanglement will be investigated, and the nature of slow modes will be elucidated. A model composite liquid has been developed which consists of small coated silica spheres and a rigid polymer immersed in a solvent. This system will also be studied by dynamic light scattering and transient electric birefringence decay. Composite liquids are a ubiquitous class of materials which contain polymer, particles and solvent. They are used as ceramic precursors, lubricants, paints and coatings, adhesives, and in chromatographic columns. Due to their complexity and the lack of adequate model systems, the interactions between the species in such systems are not well understood. Pecora has constructed a model rod/sphere composite liquid whose dynamics can be studied over a wide range of composition of both the rods and the spheres using an experimental technique known as dynamic light scattering.
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