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Daniel H. Appella

Affiliations:			National Institutes of Health, Bethesda, MD
	2001-2004	Chemistry	Northwestern University, Evanston, IL

Area:

Organic Chemistry

Website:

https://www.niddk.nih.gov/about-niddk/staff-directory/intramural/daniel-appella/pages/research-summary.aspx

Google:

"Daniel Appella"

Bio:

http://gellman.chem.wisc.edu/members-former

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Parents

Samuel H. Gellman	grad student	1998	UW Madison
(Synthesis and characterization of Helical β-peptides)
Stephen L. Buchwald	post-doc	1998-2001	MIT

Children

Mark A. Witschi	grad student	2006	Northwestern
Ethan A. Englund	grad student	2007	Northwestern
Jonathan K. Pokorski	grad student	2007	Northwestern
Jaclyn A. Iera	grad student	2008	Northwestern
Ethan A. Englund	post-doc		National Insitutes of Health
Hosahudya N. Gopi	post-doc	2002-2003	Northwestern
Matthew D. Hassink	post-doc	2014	National Institutes of Health
Andrew Dix	post-doc	2011-2014	National Insitutes of Health
Nathaniel I. Shank	post-doc	2012-2015	National Insitutes of Health
Kara G. Rosenker	post-doc	2016	NIH
Michael T. Scerba	post-doc	2016	NIH
Mrinmoy Saha	post-doc	2015-2017	NIH
Herman Nikolayevskiy	post-doc	2017-2019	NIH

Collaborators

BETA: Related publications

Publications

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Robello M, Nikolayevskiy H, Scerba MT, et al. (2023) Prodrug Strategy Extends the Use of Anti-HIV Sulfanylbenzamides for Application . Acs Pharmacology & Translational Science. 7: 259-273
Robello M, Zheng H, Saha M, et al. (2022) Alkyl-substituted N-methylaryl-N'-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase. European Journal of Medicinal Chemistry. 243: 114763
Zheng H, Botos I, Clausse V, et al. (2021) Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA. Nucleic Acids Research
Fouz MF, Appella DH. (2020) PNA Clamping in Nucleic Acid Amplification Protocols to Detect Single Nucleotide Mutations Related to Cancer. Molecules (Basel, Switzerland). 25
Clausse V, Tao D, Debnath S, et al. (2019) Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. The Journal of Biological Chemistry
Nikolayevskiy H, Robello M, Scerba MT, et al. (2019) The structure-activity profile of mercaptobenzamides' anti-HIV activity suggests that thermodynamics of metabolism is more important than binding affinity to the target. European Journal of Medicinal Chemistry. 178: 818-837
Miller Jenkins LM, Paine E, Deshmukh L, et al. (2019) Inhibition of HIV Maturation via Selective Unfolding and Crosslinking of Gag Polyprotein by a Mercaptobenzamide Acetylator. Journal of the American Chemical Society
Shank N, George Rosenker KM, Englund EA, et al. (2019) Synthesis and Application of KγT Peptide Nucleic Acids. Methods in Molecular Biology (Clifton, N.J.). 1973: 131-145
Zheng H, Saha M, Appella DH. (2018) Synthesis of Fmoc-Protected ( S, S)- trans-Cyclopentane Diamine Monomers Enables the Preparation and Study of Conformationally Restricted Peptide Nucleic Acids. Organic Letters
Nikolayevskiy H, Scerba MT, Deschamps JR, et al. (2018) Reaction Kinetics Direct a Rational Synthesis of an HIV-1 Inactivator of Nucleocapsid Protein 7 and Provide Mechanistic Insight into Cellular Metabolism and Antiviral Activity. Chemistry (Weinheim An Der Bergstrasse, Germany)

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