Michael W. Handlogten, Ph.D.

Affiliations: 
2013 University of Notre Dame, Notre Dame, IN, United States 
Area:
Biomedical Engineering, Biochemistry, Molecular Biology
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"Michael Handlogten"

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Z. Başar Bilgiçer grad student 2013 Notre Dame (Chemistry Tree)
 (Design of a heterobivalent inhibitor of allergy and more physiologically relevant allergy models.)
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Publications

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Handlogten MW, Peng L, Christian EA, et al. (2020) Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region. Mabs. 12: 1779974
Handlogten MW, Wang J, Ahuja S. (2020) Online Control of Cell Culture Redox Potential Prevents Antibody Interchain Disulfide Bond Reduction. Biotechnology and Bioengineering
Swope N, Keen Chung W, Cao M, et al. (2020) Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation. Biotechnology and Bioengineering
Handlogten MW, Zhu M, Ahuja S. (2018) Intracellular response of CHO cells to oxidative stress and its influence on metabolism and antibody production Biochemical Engineering Journal. 133: 12-20
Handlogten MW, Lee-O'Brien A, Roy G, et al. (2017) Intracellular Response to Process Optimization and Impact on Productivity and Product Aggregates for a high-titer CHO Cell Process. Biotechnology and Bioengineering
Handlogten MW, Zhu M, Ahuja S. (2017) Glutathione and thioredoxin systems contribute to recombinant monoclonal antibody interchain disulfide bond reduction during bioprocessing. Biotechnology and Bioengineering
Chung WK, Russell B, Yang Y, et al. (2017) Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability. Biotechnology and Bioengineering
Handlogten MW, Deak PE, Bilgicer B. (2014) Two-allergen model reveals complex relationship between IgE crosslinking and degranulation. Chemistry & Biology. 21: 1445-51
Handlogten MW, Stefanick JF, Deak PE, et al. (2014) Affinity-based precipitation via a bivalent peptidic hapten for the purification of monoclonal antibodies. The Analyst. 139: 4247-55
Handlogten MW, Serezani AP, Sinn AL, et al. (2014) A heterobivalent ligand inhibits mast cell degranulation via selective inhibition of allergen-IgE interactions in vivo. Journal of Immunology (Baltimore, Md. : 1950). 192: 2035-41
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