K. Barry Sharpless
Affiliations: | Massachusetts Institute of Technology, Cambridge, MA, United States | ||
| Scripps Research Institute, La Jolla, La Jolla, CA, United States |
Area:
Click chemistryWebsite:
http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2001/sharpless-bio.htmlGoogle:
"K. Barry Sharpless"Bio:
The Nobel Prize in Chemistry 2001 was divided, one half jointly to William S. Knowles and Ryoji Noyori "for their work on chirally catalysed hydrogenation reactions" and the other half to K. Barry Sharpless "for his work on chirally catalysed oxidation reactions".
The Nobel Prize in Chemistry 2022 was awarded jointly to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless "for the development of click chemistry and bioorthogonal chemistry".
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Mean distance: 6.5 | S | N | B | C | P |
Parents
Sign in to add mentor| Thomas A. Spencer | research assistant | 1963 | Dartmouth | |
| Eugene van Tamelen | grad student | 1968 | Stanford | |
| (Studies of the mechanism of action of 2,3-oxidosqualenelanosterol cyclase featuring enzymic cyclization of modified squalene oxides.) | ||||
| James Paddock Collman | post-doc | 1968 | Stanford | |
| Konrad Bloch | post-doc | 1969 | Harvard | |
Children
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Publications
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| McFadden WM, Casey-Moore MC, Bare GAL, et al. (2024) Identification of clickable HIV-1 capsid-targeting probes for viral replication inhibition. Cell Chemical Biology. 31: 477-486.e7 |
| Yang B, Sukheja P, Qin B, et al. (2023) Synthesis and structure-activity relationships of aryl fluorosulfate-based inhibitors as novel antitubercular agents. Bioorganic & Medicinal Chemistry Letters. 98: 129596 |
| Li H, Chang BS, Kim H, et al. (2023) High-performing polysulfate dielectrics for electrostatic energy storage under harsh conditions. Joule. 7: 95-111 |
| Xin Y, Liu S, Liu Y, et al. (2023) Affinity selection of double-click triazole libraries for rapid discovery of allosteric modulators for GLP-1 receptor. Proceedings of the National Academy of Sciences of the United States of America. 120: e2220767120 |
| Cheng Y, Li G, Smedley CJ, et al. (2022) Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 119: e2208540119 |
| Kim H, Zhao J, Bae J, et al. (2021) Chain-Growth Sulfur(VI) Fluoride Exchange Polycondensation: Molecular Weight Control and Synthesis of Degradable Polysulfates. Acs Central Science. 7: 1919-1928 |
| Li S, Li G, Gao B, et al. (2021) SuFExable polymers with helical structures derived from thionyl tetrafluoride. Nature Chemistry |
| Dong J, Sharpless KB, Gao B, et al. (2021) Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines. Angewandte Chemie (International Ed. in English) |
| Zhang J, Zhao X, Cappiello JR, et al. (2021) Identification of simple arylfluorosulfates as potent agents against resistant bacteria. Proceedings of the National Academy of Sciences of the United States of America. 118 |
| Garnar-Wortzel L, Bishop TR, Kitamura S, et al. (2021) Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia. Acs Central Science. 7: 815-830 |