John M. Harrold, Ph.D.
Affiliations: | 2005 | University of Pittsburgh, Pittsburgh, PA, United States |
Area:
Chemical EngineeringGoogle:
"John Harrold"Parents
Sign in to add mentor| Robert S. Parker | grad student | 2005 | University of Pittsburgh | |
| (Model-based design of cancer chemotherapy treatment schedules.) | ||||
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Publications
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| Harrold J, Gisleskog PO, Perez-Ruixo JJ, et al. (2020) Prediction of survival benefit of filgrastim in adult and pediatric patients with acute radiation syndrome. Clinical and Translational Science |
| Belmontes B, Tan H, Zhong W, et al. (2020) Abstract PR12: Assessing in vivo mechanisms regulating the therapeutic activity of bi-specific T-cell engager (BiTE®) molecules in immunocompetent mice expressing a chimeric human/mouse CD3ε receptor Cancer Immunology Research. 8 |
| Melhem M, Delor I, Pérez-Ruixo JJ, et al. (2018) Pharmacokinetic-pharmacodynamic modelling of neutrophil response to G-CSF in healthy subjects and patients with chemotherapy-induced neutropenia. British Journal of Clinical Pharmacology |
| Krzyzanski W, Harrold JM, Wu LS, et al. (2016) A cell-level model of pharmacodynamics-mediated drug disposition. Journal of Pharmacokinetics and Pharmacodynamics |
| Krzyzanski W, Perez-Ruixo JJ, Harrold J. (2015) Pharmacodynamic model for chemoradiotherapy-induced thrombocytopenia in mice Journal of Pharmacokinetics and Pharmacodynamics. 42: 709-720 |
| Chudasama VL, Zutshi A, Singh P, et al. (2015) Simulations of site-specific target-mediated pharmacokinetic models for guiding the development of bispecific antibodies. Journal of Pharmacokinetics and Pharmacodynamics. 42: 1-18 |
| Harrold JM, Abraham AK. (2014) Ubiquity: a framework for physiological/mechanism-based pharmacokinetic/pharmacodynamic model development and deployment. Journal of Pharmacokinetics and Pharmacodynamics. 41: 141-51 |
| Harrold J, Jacqmin P, Olsson P, et al. (2014) Translational Modeling to Identify Human Dosing of Filgrastim to Improve Overall Survival (OS) in Acute Radiation Syndrome (ARS) Blood. 124: 690-690 |
| Harrold JM, Ramanathan M, Mager DE. (2013) Network-based approaches in drug discovery and early development. Clinical Pharmacology and Therapeutics. 94: 651-8 |
| Chudasama VL, Schaedeli Stark F, Harrold JM, et al. (2012) Semi-mechanistic population pharmacokinetic model of multivalent trastuzumab emtansine in patients with metastatic breast cancer. Clinical Pharmacology and Therapeutics. 92: 520-7 |