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Brian A. Kelch, Ph.D. - Publications

Affiliations: 
2007 University of California, San Francisco, San Francisco, CA 
 2012- University of Massachusetts Medical School, Worcester, MA, United States 
Area:
Structure, function, and folding of proteins, chromosomes, and centrosomes
Website:
https://profiles.umassmed.edu/display/132262
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Landeck JT, Pajak J, Norman EK, Sedivy EL, Kelch BA. Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication. The Journal of Biological Chemistry. 107166. PMID 38490435 DOI: 10.1016/j.jbc.2024.107166  0.414
2023 Landeck JT, Pajak J, Norman EK, Sedivy EL, Kelch BA. Differences in clamp loader mechanism between bacteria and eukaryotes. Biorxiv : the Preprint Server For Biology. PMID 38076975 DOI: 10.1101/2023.11.30.569468  0.377
2023 Magrino J, Munford V, Martins DJ, Homma TK, Page B, Gaubitz C, Freire BL, Lerario AM, Vilar JB, Amorin A, Leão EKE, Kok F, Menck CFM, Jorge AAL, Kelch BA. A thermosensitive PCNA allele underlies an Ataxia Telangiectasia-like disorder. The Journal of Biological Chemistry. 104656. PMID 36990216 DOI: 10.1016/j.jbc.2023.104656  0.335
2022 Li H, O'Donnell M, Kelch B. Unexpected new insights into DNA clamp loaders: Eukaryotic clamp loaders contain a second DNA site for recessed 5' ends that facilitates repair and signals DNA damage: Eukaryotic clamp loaders contain a second DNA site for recessed 5' ends that facilitates repair and signals DNA damage. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e2200154. PMID 36116108 DOI: 10.1002/bies.202200154  0.483
2022 Özden C, Sloutsky R, Mitsugi T, Santos N, Agnello E, Gaubitz C, Foster J, Lapinskas E, Esposito EA, Saneyoshi T, Kelch BA, Garman SC, Hayashi Y, Stratton MM. CaMKII binds both substrates and activators at the active site. Cell Reports. 40: 111064. PMID 35830796 DOI: 10.1016/j.celrep.2022.111064  0.554
2022 Liu X, Gaubitz C, Pajak J, Kelch BA. A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA. Elife. 11. PMID 35731107 DOI: 10.7554/eLife.77483  0.487
2022 Gaubitz C, Liu X, Pajak J, Stone NP, Hayes JA, Demo G, Kelch BA. Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader. Elife. 11. PMID 35179493 DOI: 10.7554/eLife.74175  0.538
2021 Pajak J, Dill E, Reyes-Aldrete E, White MA, Kelch BA, Jardine PJ, Arya G, Morais MC. Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor. Nucleic Acids Research. PMID 34050764 DOI: 10.1093/nar/gkab372  0.301
2021 Pajak J, Atz R, Hilbert BJ, Morais MC, Kelch BA, Jardine PJ, Arya G. Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33888587 DOI: 10.1073/pnas.2024928118  0.432
2020 Gaubitz C, Liu X, Magrino J, Stone NP, Landeck J, Hedglin M, Kelch BA. Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch. Proceedings of the National Academy of Sciences of the United States of America. PMID 32907938 DOI: 10.1073/Pnas.2007437117  0.596
2020 Hayes JA, Hilbert BJ, Gaubitz C, Stone NP, Kelch BA. A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry. The Journal of Biological Chemistry. PMID 32014998 DOI: 10.1074/Jbc.Ra119.012224  0.584
2019 Stone NP, Demo G, Agnello E, Kelch BA. Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure. Nature Communications. 10: 4471. PMID 31578335 DOI: 10.1038/S41467-019-12341-Z  0.43
2019 Paul Solomon Devakumar LJ, Gaubitz C, Lundblad V, Kelch BA, Kubota T. Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex. Nucleic Acids Research. PMID 31114918 DOI: 10.1093/Nar/Gkz441  0.499
2018 Stone NP, Hilbert BJ, Hidalgo D, Halloran KT, Lee J, Sontheimer EJ, Kelch BA. A Hyperthermophilic Phage Decoration Protein Suggests Common Evolutionary Origin with Herpesvirus Triplex Proteins and an Anti-CRISPR Protein. Structure (London, England : 1993). PMID 29779790 DOI: 10.1016/J.Str.2018.04.008  0.393
2018 Silvas TV, Hou S, Myint W, Nalivaika E, Somasundaran M, Kelch BA, Matsuo H, Kurt Yilmaz N, Schiffer CA. Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions. Scientific Reports. 8: 7511. PMID 29760455 DOI: 10.1038/S41598-018-25881-Z  0.485
2017 Kouno T, Silvas TV, Hilbert BJ, Shandilya SMD, Bohn MF, Kelch BA, Royer WE, Somasundaran M, Kurt Yilmaz N, Matsuo H, Schiffer CA. Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity. Nature Communications. 8: 15024. PMID 28452355 DOI: 10.1038/Ncomms15024  0.497
2017 Hilbert BJ, Hayes JA, Stone NP, Xu RG, Kelch BA. The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain. Nucleic Acids Research. PMID 28082398 DOI: 10.1093/Nar/Gkw1356  0.588
2016 Kelch BA. Review: The lord of the rings: Structure and mechanism of the sliding clamp loader. Biopolymers. 105: 532-46. PMID 26918303 DOI: 10.1002/Bip.22827  0.456
2015 Duffy CM, Hilbert BJ, Kelch BA. A disease-causing variant in PCNA disrupts a promiscuous protein binding site. Journal of Molecular Biology. PMID 26688547 DOI: 10.1016/J.Jmb.2015.11.029  0.482
2015 Hilbert BJ, Hayes JA, Stone NP, Duffy CM, Sankaran B, Kelch BA. Structure and mechanism of the ATPase that powers viral genome packaging. Proceedings of the National Academy of Sciences of the United States of America. 112: E3792-9. PMID 26150523 DOI: 10.1073/Pnas.1506951112  0.392
2015 Bohn MF, Shandilya SM, Silvas TV, Nalivaika EA, Kouno T, Kelch BA, Ryder SP, Kurt-Yilmaz N, Somasundaran M, Schiffer CA. The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization. Structure (London, England : 1993). 23: 903-11. PMID 25914058 DOI: 10.1016/J.Str.2015.03.016  0.494
2013 Barros T, Guenther J, Kelch B, Anaya J, Prabhakar A, O'Donnell M, Kuriyan J, Lamers MH. A structural role for the PHP domain in E. coli DNA polymerase III Bmc Structural Biology. 13. PMID 23672456 DOI: 10.1186/1472-6807-13-8  0.703
2012 Kelch BA, Salimi NL, Agard DA. Functional modulation of a protein folding landscape via side-chain distortion. Proceedings of the National Academy of Sciences of the United States of America. 109: 9414-9. PMID 22635267 DOI: 10.1073/Pnas.1119274109  0.633
2012 Kelch BA, Makino DL, O'Donnell M, Kuriyan J. Clamp loader ATPases and the evolution of DNA replication machinery Bmc Biology. 10. PMID 22520345 DOI: 10.1186/1741-7007-10-34  0.695
2012 Kelch B, Makino D, Simonetta K, O'Donnell M, Kuriyan J. Molecular mechanisms of DNA polymerase clamp loaders Nato Science For Peace and Security Series a: Chemistry and Biology. 103-114. DOI: 10.1007/978-94-007-2530-0_10  0.705
2011 Kelch BA, Makino DL, O'Donnell M, Kuriyan J. How a DNA polymerase clamp loader opens a sliding clamp. Science (New York, N.Y.). 334: 1675-80. PMID 22194570 DOI: 10.1126/Science.1211884  0.702
2011 Kelch BA, Makino DL, O'Donnell M, Kuriyan J. How a DNA polymerase clamp loader opens a sliding clamp Science. 334: 1675-1680. DOI: 10.1126/science.1211884  0.64
2009 Simonetta KR, Kazmirski SL, Goedken ER, Cantor AJ, Kelch BA, McNally R, Seyedin SN, Makino DL, O'Donnell M, Kuriyan J. The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell. 137: 659-71. PMID 19450514 DOI: 10.1016/J.Cell.2009.03.044  0.649
2007 Kelch BA, Agard DA. Mesophile versus thermophile: insights into the structural mechanisms of kinetic stability. Journal of Molecular Biology. 370: 784-95. PMID 17543987 DOI: 10.1016/J.Jmb.2007.04.078  0.587
2007 Kelch BA, Eagen KP, Erciyas FP, Humphris EL, Thomason AR, Mitsuiki S, Agard DA. Structural and mechanistic exploration of acid resistance: kinetic stability facilitates evolution of extremophilic behavior. Journal of Molecular Biology. 368: 870-83. PMID 17382344 DOI: 10.1016/J.Jmb.2007.02.032  0.54
2004 Fuhrmann CN, Kelch BA, Ota N, Agard DA. The 0.83 A resolution crystal structure of alpha-lytic protease reveals the detailed structure of the active site and identifies a source of conformational strain. Journal of Molecular Biology. 338: 999-1013. PMID 15111063 DOI: 10.1016/J.Jmb.2004.03.018  0.553
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