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Theresa Alenghat, Ph.D. - Publications

Affiliations: 
2007 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Molecular Biology
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Eshleman EM, Rice T, Potter C, Waddell A, Hashimoto-Hill S, Woo V, Field S, Engleman L, Lim HW, Schumacher MA, Frey MR, Denson LA, Finkelman FD, Alenghat T. Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity. Immunity. PMID 38295798 DOI: 10.1016/j.immuni.2024.01.002  0.331
2023 Eshleman EM, Shao TY, Woo V, Rice T, Engleman L, Didriksen BJ, Whitt J, Haslam DB, Way SS, Alenghat T. Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity. The Journal of Clinical Investigation. 133. PMID 36602872 DOI: 10.1172/JCI162190  0.342
2022 Woo V, Alenghat T. Epigenetic regulation by gut microbiota. Gut Microbes. 14: 2022407. PMID 35000562 DOI: 10.1080/19490976.2021.2022407  0.339
2020 Almanan M, Raynor J, Ogunsulire I, Malyshkina A, Mukherjee S, Hummel SA, Ingram JT, Saini A, Xie MM, Alenghat T, Way SS, Deepe GS, Divanovic S, Singh H, Miraldi E, et al. IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression. Science Advances. 6: eabb0806. PMID 32832688 DOI: 10.1126/Sciadv.Abb0806  0.337
2020 Wu SE, Hashimoto-Hill S, Woo V, Eshleman EM, Whitt J, Engleman L, Karns R, Denson LA, Haslam DB, Alenghat T. Microbiota-derived metabolite promotes HDAC3 activity in the gut. Nature. PMID 32731255 DOI: 10.1038/S41586-020-2604-2  0.45
2020 Oherle K, Acker E, Bonfield M, Wang T, Gray J, Lang I, Bridges J, Lewkowich I, Xu Y, Ahlfeld S, Zacharias W, Alenghat T, Deshmukh H. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity. 52: 716-718. PMID 32294410 DOI: 10.1016/J.Immuni.2020.03.018  0.318
2019 Boucher AA, Rosenfeldt L, Mureb D, Shafer J, Sharma BK, Lane A, Crowther RR, McKell MC, Whitt J, Alenghat T, Qualls J, Antoniak S, Mackman N, Flick MJ, Steinbrecher KA, et al. Cell type-specific mechanisms coupling protease-activated receptor-1 to infectious colitis pathogenesis. Journal of Thrombosis and Haemostasis : Jth. PMID 31539206 DOI: 10.1111/Jth.14641  0.344
2019 Woo V, Eshleman EM, Rice T, Whitt J, Vallance BA, Alenghat T. Microbiota Inhibit Epithelial Pathogen Adherence by Epigenetically Regulating C-Type Lectin Expression. Frontiers in Immunology. 10: 928. PMID 31134059 DOI: 10.3389/Fimmu.2019.00928  0.455
2018 Waddell A, Vallance JE, Hummel A, Alenghat T, Rosen MJ. IL-33 Induces Murine Intestinal Goblet Cell Differentiation Indirectly via Innate Lymphoid Cell IL-13 Secretion. Journal of Immunology (Baltimore, Md. : 1950). PMID 30530480 DOI: 10.4049/Jimmunol.1800292  0.342
2018 Kelly D, Kotliar M, Woo V, Jagannathan S, Whitt J, Moncivaiz J, Aronow BJ, Dubinsky MC, Hyams JS, Markowitz JF, Baldassano RN, Stephens MC, Walters TD, Kugathasan S, Haberman Y, ... ... Alenghat T, et al. Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease. Jci Insight. 3. PMID 30232290 DOI: 10.1172/Jci.Insight.122104  0.463
2018 Whitt J, Woo V, Lee P, Moncivaiz J, Haberman Y, Denson L, Tso P, Alenghat T. Disruption of Epithelial HDAC3 in Intestine Prevents Diet-induced Obesity in Mice. Gastroenterology. PMID 29689264 DOI: 10.1053/J.Gastro.2018.04.017  0.392
2018 Kelly DR, Kotliar M, Woo V, Jagannathan S, Whitt J, Moncivaiz J, Haberman Y, Barski A, Denson LA, Alenghat T. 635 - Intestinal Microbiota Direct an Epithelial Epigenetic Signature of Pediatric Crohn's Disease Gastroenterology. 154: S-133-S-134. DOI: 10.1016/S0016-5085(18)30872-2  0.313
2017 Jiang TT, Shao TY, Ang WXG, Kinder JM, Turner LH, Pham G, Whitt J, Alenghat T, Way SS. Commensal Fungi Recapitulate the Protective Benefits of Intestinal Bacteria. Cell Host & Microbe. 22: 809-816.e4. PMID 29174402 DOI: 10.1016/J.Chom.2017.10.013  0.366
2017 Navabi N, Whitt J, Wu SE, Woo V, Moncivaiz J, Jordan MB, Vallance BA, Way SS, Alenghat T. Epithelial Histone Deacetylase 3 Instructs Intestinal Immunity by Coordinating Local Lymphocyte Activation. Cell Reports. 19: 1165-1175. PMID 28494866 DOI: 10.1016/J.Celrep.2017.04.046  0.48
2017 Gray J, Oehrle K, Worthen G, Alenghat T, Whitsett J, Deshmukh H. Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection. Science Translational Medicine. 9. PMID 28179507 DOI: 10.1126/Scitranslmed.Aaf9412  0.396
2017 Woo V, Alenghat T. Host-microbiota interactions: epigenomic regulation. Current Opinion in Immunology. 44: 52-60. PMID 28103497 DOI: 10.1016/J.Coi.2016.12.001  0.392
2015 Giacomin PR, Moy RH, Noti M, Osborne LC, Siracusa MC, Alenghat T, Liu B, McCorkell KA, Troy AE, Rak GD, Hu Y, May MJ, Ma HL, Fouser LA, Sonnenberg GF, et al. Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity. The Journal of Experimental Medicine. PMID 26371187 DOI: 10.1084/Jem.20141831  0.624
2015 Tait Wojno ED, Monticelli LA, Tran SV, Alenghat T, Osborne LC, Thome JJ, Willis C, Budelsky A, Farber DL, Artis D. The prostaglandin D2 receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung. Mucosal Immunology. PMID 25850654 DOI: 10.1038/Mi.2015.21  0.609
2015 Whitsett JA, Alenghat T. Respiratory epithelial cells orchestrate pulmonary innate immunity. Nature Immunology. 16: 27-35. PMID 25521682 DOI: 10.1038/Ni.3045  0.327
2015 Alenghat T. Epigenomics and the microbiota. Toxicologic Pathology. 43: 101-6. PMID 25330924 DOI: 10.1177/0192623314553805  0.461
2014 Alenghat T, Artis D. Epigenomic regulation of host-microbiota interactions. Trends in Immunology. 35: 518-25. PMID 25443494 DOI: 10.1016/J.It.2014.09.007  0.615
2013 Alenghat T, Osborne LC, Saenz SA, Kobuley D, Ziegler CG, Mullican SE, Choi I, Grunberg S, Sinha R, Wynosky-Dolfi M, Snyder A, Giacomin PR, Joyce KL, Hoang TB, Bewtra M, et al. Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis. Nature. 504: 153-7. PMID 24185009 DOI: 10.1038/Nature12687  0.697
2013 Osborne LC, Joyce KL, Alenghat T, Sonnenberg GF, Giacomin PR, Du Y, Bergstrom KS, Vallance BA, Nair MG. Resistin-like molecule α promotes pathogenic Th17 cell responses and bacterial-induced intestinal inflammation. Journal of Immunology (Baltimore, Md. : 1950). 190: 2292-300. PMID 23355735 DOI: 10.4049/Jimmunol.1200706  0.407
2012 Abt MC, Osborne LC, Monticelli LA, Doering TA, Alenghat T, Sonnenberg GF, Paley MA, Antenus M, Williams KL, Erikson J, Wherry EJ, Artis D. Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity. 37: 158-70. PMID 22705104 DOI: 10.1016/J.Immuni.2012.04.011  0.718
2012 Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hutnick NA, Kunisawa J, Shibata N, Grunberg S, Sinha R, Zahm AM, Tardif MR, Sathaliyawala T, Kubota M, Farber DL, Collman RG, et al. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science (New York, N.Y.). 336: 1321-5. PMID 22674331 DOI: 10.1126/Science.1222551  0.603
2011 Mullican SE, Gaddis CA, Alenghat T, Nair MG, Giacomin PR, Everett LJ, Feng D, Steger DJ, Schug J, Artis D, Lazar MA. Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation. Genes & Development. 25: 2480-8. PMID 22156208 DOI: 10.1101/Gad.175950.111  0.704
2011 Monticelli LA, Sonnenberg GF, Abt MC, Alenghat T, Ziegler CG, Doering TA, Angelosanto JM, Laidlaw BJ, Yang CY, Sathaliyawala T, Kubota M, Turner D, Diamond JM, Goldrath AW, Farber DL, et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nature Immunology. 12: 1045-54. PMID 21946417 DOI: 10.1031/Ni.2131  0.714
2011 Feng D, Liu T, Sun Z, Bugge A, Mullican SE, Alenghat T, Liu XS, Lazar MA. A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science (New York, N.Y.). 331: 1315-9. PMID 21393543 DOI: 10.1126/Science.1198125  0.673
2011 McQuown SC, Barrett RM, Matheos DP, Post RJ, Rogge GA, Alenghat T, Mullican SE, Jones S, Rusche JR, Lazar MA, Wood MA. HDAC3 is a critical negative regulator of long-term memory formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 764-74. PMID 21228185 DOI: 10.1523/Jneurosci.5052-10.2011  0.569
2008 Alenghat T, Meyers K, Mullican SE, Leitner K, Adeniji-Adele A, Avila J, Bućan M, Ahima RS, Kaestner KH, Lazar MA. Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature. 456: 997-1000. PMID 19037247 DOI: 10.1038/Nature07541  0.612
2008 Alenghat T, Lazar MA. Nuclear receptor corepressors and metabolism Nr Coregulators and Human Diseases. 370-395. DOI: 10.1142/9789812819178_0011  0.525
2006 Yu J, Palmer C, Alenghat T, Li Y, Kao G, Lazar MA. The corepressor silencing mediator for retinoid and thyroid hormone receptor facilitates cellular recovery from DNA double-strand breaks. Cancer Research. 66: 9316-22. PMID 16982777 DOI: 10.1158/0008-5472.Can-06-1902  0.691
2006 Alenghat T, Yu J, Lazar MA. The N-CoR complex enables chromatin remodeler SNF2H to enhance repression by thyroid hormone receptor. The Embo Journal. 25: 3966-74. PMID 16917504 DOI: 10.1038/Sj.Emboj.7601280  0.743
2005 Hartman HB, Yu J, Alenghat T, Ishizuka T, Lazar MA. The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3. Embo Reports. 6: 445-51. PMID 15832170 DOI: 10.1038/Sj.Embor.7400391  0.705
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