| Year |
Citation |
Score |
| 2020 |
Liu Y, Wang HY, Shao J, Zaro JL, Shen WC. Enhanced insulin receptor interaction by a bifunctional insulin-transferrin fusion protein: an approach to overcome insulin resistance. Scientific Reports. 10: 7724. PMID 32382087 DOI: 10.1038/S41598-020-64731-9 |
0.783 |
|
| 2019 |
Xie C, Wang Z, Su Y, Wang J, Shen WC. Discovery of An Orally Effective Factor IX-Transferrin Fusion Protein for Hemophilia B. International Journal of Molecular Sciences. 21. PMID 31861459 DOI: 10.3390/Ijms21010021 |
0.391 |
|
| 2018 |
Tang B, Zaro JL, Shen Y, Chen Q, Yu Y, Sun P, Wang Y, Shen WC, Tu J, Sun C. Acid-sensitive hybrid polymeric micelles containing a reversibly activatable cell-penetrating peptide for tumor-specific cytoplasm targeting. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 29653223 DOI: 10.1016/J.Jconrel.2018.04.016 |
0.786 |
|
| 2018 |
Liu Y, Wang HY, Zhou L, Su Y, Shen WC. Biodistribution, activation, and retention of proinsulin-transferrin fusion protein in the liver: Mechanism of liver-targeting as an insulin prodrug. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 29471040 DOI: 10.1016/J.Jconrel.2018.02.030 |
0.335 |
|
| 2018 |
Chen YS, Zaro JL, Zhang D, Huang N, Simon A, Shen WC. Characterization and Oral Delivery of Proinsulin-Transferrin Fusion Protein Expressed Using ExpressTec. International Journal of Molecular Sciences. 19. PMID 29373562 DOI: 10.3390/Ijms19020378 |
0.794 |
|
| 2017 |
Folchman-Wagner Z, Zaro J, Shen WC. Characterization of Polyelectrolyte Complex Formation Between Anionic and Cationic Poly(amino acids) and Their Potential Applications in pH-Dependent Drug Delivery. Molecules (Basel, Switzerland). 22. PMID 28665323 DOI: 10.3390/molecules22071089 |
0.786 |
|
| 2016 |
Zhou L, Wang HY, Tong S, Okamoto CT, Shen WC, Zaro JL. Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery. Biomaterials. 117: 24-31. PMID 27923197 DOI: 10.1016/J.Biomaterials.2016.11.051 |
0.801 |
|
| 2016 |
Shao J, Zaro JL, Shen WC. Tissue barriers and novel approaches to achieve hepatoselectivity of subcutaneously-injected insulin therapeutics. Tissue Barriers. 4: e1156804. PMID 27358753 DOI: 10.1080/21688370.2016.1156804 |
0.777 |
|
| 2016 |
Shao J, Zaro JL, Shen WC. Proinsulin-transferrin fusion protein exhibits a prolonged and selective effect on the control of hepatic glucose production in an experimental model of type 1 diabetes. Molecular Pharmaceutics. PMID 27280852 DOI: 10.1021/Acs.Molpharmaceut.6B00168 |
0.782 |
|
| 2015 |
Yeh TH, Chen YR, Chen SY, Shen WC, Ann DK, Zaro JL, Shen LJ. Selective intracellular delivery of recombinant arginine deiminase (ADI) using pH-sensitive cell penetrating peptides to overcome ADI resistance in hypoxic breast cancer cells. Molecular Pharmaceutics. PMID 26642391 DOI: 10.1021/Acs.Molpharmaceut.5B00706 |
0.799 |
|
| 2015 |
Zaro JL, Shen WC. Cationic and amphipathic cell-penetrating peptides (CPPs): Their structures and in vivo studies in drug delivery Frontiers of Chemical Science and Engineering. DOI: 10.1007/S11705-015-1538-Y |
0.807 |
|
| 2014 |
Sun C, Shen WC, Tu J, Zaro JL. Interaction between cell-penetrating peptides and acid-sensitive anionic oligopeptides as a model for the design of targeted drug carriers. Molecular Pharmaceutics. 11: 1583-90. PMID 24697211 DOI: 10.1021/Mp400747K |
0.783 |
|
| 2014 |
Fei L, Yap LP, Conti PS, Shen WC, Zaro JL. Tumor targeting of a cell penetrating peptide by fusing with a pH-sensitive histidine-glutamate co-oligopeptide. Biomaterials. 35: 4082-7. PMID 24508076 DOI: 10.1016/J.Biomaterials.2014.01.047 |
0.817 |
|
| 2014 |
Wang Y, Shao J, Zaro JL, Shen WC. Proinsulin-transferrin fusion protein as a novel long-acting insulin analog for the inhibition of hepatic glucose production. Diabetes. 63: 1779-88. PMID 24353179 DOI: 10.2337/Db13-0973 |
0.789 |
|
| 2013 |
Chen X, Zaro JL, Shen WC. Fusion protein linkers: property, design and functionality. Advanced Drug Delivery Reviews. 65: 1357-69. PMID 23026637 DOI: 10.1016/J.Addr.2012.09.039 |
0.786 |
|
| 2013 |
Hackett MJ, Zaro JL, Shen WC, Guley PC, Cho MJ. Fatty acids as therapeutic auxiliaries for oral and parenteral formulations. Advanced Drug Delivery Reviews. 65: 1331-9. PMID 22921839 DOI: 10.1016/J.Addr.2012.07.012 |
0.795 |
|
| 2012 |
Zhang D, Lee HF, Pettit SC, Zaro JL, Huang N, Shen WC. Characterization of transferrin receptor-mediated endocytosis and cellular iron delivery of recombinant human serum transferrin from rice (Oryza sativa L.). Bmc Biotechnology. 12: 92. PMID 23194296 DOI: 10.1186/1472-6750-12-92 |
0.789 |
|
| 2012 |
Kenien R, Shen WC, Zaro JL. Vesicle-to-cytosol transport of disulfide-linked cargo mediated by an amphipathic cell-penetrating peptide. Journal of Drug Targeting. 20: 793-800. PMID 22994388 DOI: 10.3109/1061186X.2012.719899 |
0.778 |
|
| 2012 |
Bobst CE, Wang S, Shen WC, Kaltashov IA. Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery. Proceedings of the National Academy of Sciences of the United States of America. 109: 13544-8. PMID 22869744 DOI: 10.1073/Pnas.1206924109 |
0.386 |
|
| 2012 |
Chen X, Zaro JL, Shen WC. Pharmacokinetics of recombinant bifunctional fusion proteins. Expert Opinion On Drug Metabolism & Toxicology. 8: 581-95. PMID 22428984 DOI: 10.1517/17425255.2012.673585 |
0.788 |
|
| 2012 |
Zaro JL, Fei L, Shen WC. Recombinant peptide constructs for targeted cell penetrating peptide-mediated delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. 158: 357-61. PMID 22326404 DOI: 10.1016/J.Jconrel.2012.01.039 |
0.815 |
|
| 2012 |
Kenien R, Zaro JL, Shen WC. MAP-mediated nuclear delivery of a cargo protein. Journal of Drug Targeting. 20: 329-37. PMID 22225540 DOI: 10.3109/1061186X.2011.649481 |
0.783 |
|
| 2012 |
Mo RH, Zaro JL, Shen WC. Comparison of cationic and amphipathic cell penetrating peptides for siRNA delivery and efficacy. Molecular Pharmaceutics. 9: 299-309. PMID 22171592 DOI: 10.1021/Mp200481G |
0.795 |
|
| 2012 |
Mo RH, Zaro JL, Ou JH, Shen WC. Effects of Lipofectamine 2000/siRNA complexes on autophagy in hepatoma cells. Molecular Biotechnology. 51: 1-8. PMID 21660602 DOI: 10.1007/S12033-011-9422-6 |
0.784 |
|
| 2011 |
Wang Y, Chen YS, Zaro JL, Shen WC. Receptor-mediated activation of a proinsulin-transferrin fusion protein in hepatoma cells. Journal of Controlled Release : Official Journal of the Controlled Release Society. 155: 386-92. PMID 21756950 DOI: 10.1016/J.Jconrel.2011.06.029 |
0.808 |
|
| 2011 |
Chen X, Lee HF, Zaro JL, Shen WC. Effects of receptor binding on plasma half-life of bifunctional transferrin fusion proteins. Molecular Pharmaceutics. 8: 457-65. PMID 21291258 DOI: 10.1021/Mp1003064 |
0.788 |
|
| 2011 |
Fei L, Ren L, Zaro JL, Shen WC. The influence of net charge and charge distribution on cellular uptake and cytosolic localization of arginine-rich peptides. Journal of Drug Targeting. 19: 675-80. PMID 21142649 DOI: 10.3109/1061186X.2010.531729 |
0.793 |
|
| 2010 |
Chen X, Bai Y, Zaro JL, Shen WC. Design of an in vivo cleavable disulfide linker in recombinant fusion proteins. Biotechniques. 49: 513-8. PMID 20615204 DOI: 10.2144/000113450 |
0.795 |
|
| 2010 |
Amet N, Wang W, Shen WC. Human growth hormone-transferrin fusion protein for oral delivery in hypophysectomized rats. Journal of Controlled Release : Official Journal of the Controlled Release Society. 141: 177-82. PMID 19761807 DOI: 10.1016/J.Jconrel.2009.09.007 |
0.798 |
|
| 2009 |
Zaro JL, Vekich JE, Tran T, Shen WC. Nuclear localization of cell-penetrating peptides is dependent on endocytosis rather than cytosolic delivery in CHO cells. Molecular Pharmaceutics. 6: 337-44. PMID 19718791 DOI: 10.1021/Mp800239P |
0.804 |
|
| 2009 |
Patel LN, Wang J, Kim KJ, Borok Z, Crandall ED, Shen WC. Conjugation with cationic cell-penetrating peptide increases pulmonary absorption of insulin. Molecular Pharmaceutics. 6: 492-503. PMID 19228019 DOI: 10.1021/Mp800174G |
0.374 |
|
| 2009 |
Barnes MP, Shen WC. Disulfide and thioether linked cytochrome c-oligoarginine conjugates in HeLa cells. International Journal of Pharmaceutics. 369: 79-84. PMID 19059469 DOI: 10.1016/J.Ijpharm.2008.10.036 |
0.638 |
|
| 2009 |
Amet N, Lee HF, Shen WC. Insertion of the designed helical linker led to increased expression of tf-based fusion proteins. Pharmaceutical Research. 26: 523-8. PMID 19002568 DOI: 10.1007/S11095-008-9767-0 |
0.782 |
|
| 2008 |
Yuan L, Wang J, Shen WC. Reversible lipidization of somatostatin analogues for the liver targeting. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 70: 615-20. PMID 18614343 DOI: 10.1016/J.Ejpb.2008.05.004 |
0.551 |
|
| 2008 |
Yuan L, Wang J, Shen WC. Lipidization of human interferon-alpha: a new approach toward improving the delivery of protein drugs. Journal of Controlled Release : Official Journal of the Controlled Release Society. 129: 11-7. PMID 18448186 DOI: 10.1016/J.Jconrel.2008.03.014 |
0.536 |
|
| 2008 |
Bahhady R, Kim KJ, Borok Z, Crandall ED, Shen WC. Characterization of protein factor(s) in rat bronchoalveolar lavage fluid that enhance insulin transport via transcytosis across primary rat alveolar epithelial cell monolayers. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 69: 808-16. PMID 18406118 DOI: 10.1016/J.Ejpb.2008.01.028 |
0.791 |
|
| 2008 |
Norouziyan F, Shen WC, Hamm-Alvarez SF. Tyrphostin A8 stimulates a novel trafficking pathway of apically endocytosed transferrin through Rab11-enriched compartments in Caco-2 cells. American Journal of Physiology. Cell Physiology. 294: C7-21. PMID 17959726 DOI: 10.1152/Ajpcell.00372.2006 |
0.79 |
|
| 2008 |
Patel LN, Uchiyama T, Kim KJ, Borok Z, Crandall ED, Shen WC, Lee VH. Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells. Journal of Pharmaceutical Sciences. 97: 2340-9. PMID 17854063 DOI: 10.1002/Jps.21134 |
0.378 |
|
| 2007 |
Lim CJ, Norouziyan F, Shen WC. Accumulation of transferrin in Caco-2 cells: a possible mechanism of intestinal transferrin absorption. Journal of Controlled Release : Official Journal of the Controlled Release Society. 122: 393-8. PMID 17586083 DOI: 10.1016/J.Jconrel.2007.03.021 |
0.789 |
|
| 2007 |
Bahhady R, Kim KJ, Borok Z, Crandall ED, Shen WC. Enhancement of insulin transport across primary rat alveolar epithelial cell monolayers by endogenous cellular factor(s). Pharmaceutical Research. 24: 1713-9. PMID 17443400 DOI: 10.1007/S11095-007-9301-9 |
0.784 |
|
| 2007 |
Patel LN, Zaro JL, Shen WC. Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives. Pharmaceutical Research. 24: 1977-92. PMID 17443399 DOI: 10.1007/S11095-007-9303-7 |
0.806 |
|
| 2006 |
Bai Y, Shen WC. Improving the oral efficacy of recombinant granulocyte colony-stimulating factor and transferrin fusion protein by spacer optimization. Pharmaceutical Research. 23: 2116-21. PMID 16952003 DOI: 10.1007/S11095-006-9059-5 |
0.31 |
|
| 2006 |
Shen LJ, Shen WC. Drug evaluation: ADI-PEG-20--a PEGylated arginine deiminase for arginine-auxotrophic cancers. Current Opinion in Molecular Therapeutics. 8: 240-8. PMID 16774044 |
0.475 |
|
| 2006 |
Wang J, Hogenkamp DJ, Tran M, Li WY, Yoshimura RF, Johnstone TB, Shen WC, Gee KW. Reversible lipidization for the oral delivery of leu-enkephalin. Journal of Drug Targeting. 14: 127-36. PMID 16753826 DOI: 10.1080/10611860600648221 |
0.355 |
|
| 2006 |
Zaro JL, Rajapaksa TE, Okamoto CT, Shen WC. Membrane transduction of oligoarginine in HeLa cells is not mediated by macropinocytosis. Molecular Pharmaceutics. 3: 181-6. PMID 16579647 DOI: 10.1021/Mp0500869 |
0.812 |
|
| 2006 |
Shen LJ, Beloussow K, Shen WC. Modulation of arginine metabolic pathways as the potential anti-tumor mechanism of recombinant arginine deiminase. Cancer Letters. 231: 30-5. PMID 16356828 DOI: 10.1016/J.Canlet.2005.01.007 |
0.542 |
|
| 2005 |
Zaro JL, Shen WC. Cytosolic delivery of a p16-peptide oligoarginine conjugate for inhibiting proliferation of MCF7 cells. Journal of Controlled Release : Official Journal of the Controlled Release Society. 108: 409-17. PMID 16202470 DOI: 10.1016/J.Jconrel.2005.08.028 |
0.797 |
|
| 2005 |
Lim CJ, Shen WC. Comparison of monomeric and oligomeric transferrin as potential carrier in oral delivery of protein drugs. Journal of Controlled Release : Official Journal of the Controlled Release Society. 106: 273-86. PMID 15964654 DOI: 10.1016/J.Jconrel.2005.05.001 |
0.664 |
|
| 2005 |
Zaro JL, Shen WC. Evidence that membrane transduction of oligoarginine does not require vesicle formation. Experimental Cell Research. 307: 164-73. PMID 15922736 DOI: 10.1016/J.Yexcr.2005.02.024 |
0.779 |
|
| 2005 |
Bai Y, Ann DK, Shen WC. Recombinant granulocyte colony-stimulating factor-transferrin fusion protein as an oral myelopoietic agent. Proceedings of the National Academy of Sciences of the United States of America. 102: 7292-6. PMID 15870205 DOI: 10.1073/Pnas.0500062102 |
0.35 |
|
| 2005 |
Yuan L, Wang J, Shen WC. Reversible lipidization prolongs the pharmacological effect, plasma duration, and liver retention of octreotide. Pharmaceutical Research. 22: 220-7. PMID 15783069 DOI: 10.1007/S11095-004-1189-Z |
0.51 |
|
| 2005 |
Shen LJ, Beloussow K, Shen WC. Accessibility of endothelial and inducible nitric oxide synthase to the intracellular citrulline-arginine regeneration pathway. Biochemical Pharmacology. 69: 97-104. PMID 15588718 DOI: 10.1016/J.Bcp.2004.09.003 |
0.508 |
|
| 2004 |
Lim CJ, Shen WC. Transferrin-oligomers as potential carriers in anticancer drug delivery. Pharmaceutical Research. 21: 1985-92. PMID 15587919 DOI: 10.1023/B:Pham.0000048188.69785.94 |
0.641 |
|
| 2004 |
Widera A, Bai Y, Shen WC. The transepithelial transport of a G-CSF-transferrin conjugate in Caco-2 cells and its myelopoietic effect in BDF1 mice. Pharmaceutical Research. 21: 278-84. PMID 15032309 DOI: 10.1023/B:Pham.0000016240.81059.Ec |
0.764 |
|
| 2003 |
Shen LJ, Lin WC, Beloussow K, Hosoya K, Terasaki T, Ann DK, Shen WC. Recombinant arginine deiminase as a differential modulator of inducible (iNOS) and endothelial (eNOS) nitric oxide synthetase activity in cultured endothelial cells. Biochemical Pharmacology. 66: 1945-52. PMID 14599552 DOI: 10.1016/S0006-2952(03)00555-0 |
0.509 |
|
| 2003 |
Widera A, Norouziyan F, Shen WC. Mechanisms of TfR-mediated transcytosis and sorting in epithelial cells and applications toward drug delivery. Advanced Drug Delivery Reviews. 55: 1439-66. PMID 14597140 DOI: 10.1016/j.addr.2003.07.004 |
0.79 |
|
| 2003 |
Widera A, Kim KJ, Crandall ED, Shen WC. Transcytosis of GCSF-transferrin across rat alveolar epithelial cell monolayers. Pharmaceutical Research. 20: 1231-8. PMID 12948021 DOI: 10.1023/A:1025005232421 |
0.787 |
|
| 2003 |
Shen WC. Oral peptide and protein delivery: unfulfilled promises? Drug Discovery Today. 8: 607-8. PMID 12867138 DOI: 10.1016/S1359-6446(03)02692-8 |
0.382 |
|
| 2003 |
Zaro JL, Shen WC. Quantitative comparison of membrane transduction and endocytosis of oligopeptides. Biochemical and Biophysical Research Communications. 307: 241-7. PMID 12859946 DOI: 10.1016/S0006-291X(03)01167-7 |
0.781 |
|
| 2003 |
Shen LJ, Lin WC, Beloussow K, Shen WC. Resistance to the anti-proliferative activity of recombinant arginine deiminase in cell culture correlates with the endogenous enzyme, argininosuccinate synthetase. Cancer Letters. 191: 165-70. PMID 12618329 DOI: 10.1016/S030-43835(02)00693-6 |
0.54 |
|
| 2002 |
Wang J, Wu D, Shen WC. Structure-activity relationship of reversibly lipidized peptides: studies of fatty acid-desmopressin conjugates. Pharmaceutical Research. 19: 609-14. PMID 12069162 DOI: 10.1023/A:1015397811161 |
0.301 |
|
| 2002 |
Xia CQ, Shen WC. Tyrphostin-8 enhances transferrin receptor-mediated transcytosis in Caco-2- cells and inreases hypoglycemic effect of orally administered insulin-transferrin conjugate in diabetic rats. Pharmaceutical Research. 18: 191-5. PMID 11405290 DOI: 10.1023/A:1011032502097 |
0.327 |
|
| 2000 |
Caldwell G, Meirim MG, Neuse EW, Beloussow K, Shen W. Journal of Inorganic and Organometallic Polymers. 10: 93-101. DOI: 10.1023/A:1009475909111 |
0.379 |
|
| 2000 |
Shen W, Beloussow K, Meirim MG, Neuse EW, Caldwell G. Journal of Inorganic and Organometallic Polymers. 10: 51-60. DOI: 10.1023/A:1009456532763 |
0.337 |
|
| 1998 |
Yeung AK, Basu SK, Wu SK, Chu C, Okamoto CT, Hamm-Alvarez SF, von Grafenstein H, Shen WC, Kim KJ, Bolger MB, Haworth IS, Ann DK, Lee VH. Molecular identification of a role for tyrosine 167 in the function of the human intestinal proton- coupled dipeptide transporter (hPepT1). Biochemical and Biophysical Research Communications. 250: 103-7. PMID 9735340 DOI: 10.1006/Bbrc.1998.9283 |
0.378 |
|
| 1997 |
Shah D, Shen WC. Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells. Journal of Pharmaceutical Sciences. 85: 1306-11. PMID 8961144 DOI: 10.1021/Js9601400 |
0.319 |
|
| 1996 |
Hamm-Alvarez SF, Sonee M, Loran-Goss K, Shen WC. Paclitaxel and nocodazole differentially alter endocytosis in cultured cells Pharmaceutical Research. 13: 1647-1656. PMID 8956329 DOI: 10.1023/A:1016432505275 |
0.333 |
|
| 1996 |
Honeycutt L, Wang J, Ekrami H, Shen WC. Comparison of pharmacokinetic parameters of a polypeptide, the Bowman-Birk protease inhibitor (BBI), and its palmitic acid conjugate Pharmaceutical Research. 13: 1373-1377. PMID 8893277 DOI: 10.1023/A:1016078118033 |
0.312 |
|
| 1996 |
Shah D, Shen WC. The paradox of transferrin receptor-mediated drug delivery--intracellular targeting or transcellular transport? Journal of Drug Targeting. 3: 243-5. PMID 8820997 DOI: 10.3109/10611869509015952 |
0.361 |
|
| 1995 |
Taub ME, Wan J, Shen WC. Transepithelial transport of tyramine across filter-grown MDCK cells via a poly(D-lysine) carrier. Pharmaceutical Research. 11: 1250-6. PMID 7816752 DOI: 10.1023/A:1018930108810 |
0.345 |
|
| 1995 |
Ekrami HM, Kennedy AR, Shen WC. Water-soluble fatty acid derivatives as acylating agents for reversible lipidization of polypeptides. Febs Letters. 371: 283-6. PMID 7556611 DOI: 10.1016/0014-5793(95)00910-2 |
0.327 |
|
| 1994 |
Shah D, Shen WC. The establishment of polarity and enhanced transcytosis of transferrin receptors in enterocyte-like Caco-2 cells. Journal of Drug Targeting. 2: 93-9. PMID 8069597 DOI: 10.3109/10611869409015897 |
0.388 |
|
| 1992 |
Taub ME, Shen WC. Polarity in the transcytotic processing of apical and basal membrane-bound peroxidase-polylysine conjugates in MDCK cells. Journal of Cellular Physiology. 150: 283-90. PMID 1734033 DOI: 10.1002/Jcp.1041500210 |
0.36 |
|
| 1992 |
Shen W, Wan J, Ekrami H. (C) Means to enhance penetration Advanced Drug Delivery Reviews. 8: 93-113. DOI: 10.1016/0169-409X(92)90016-J |
0.447 |
|
| 1991 |
Mandel R, Ryser HJ, Niaki B, Ghani F, Shen WC. Isolation of variants of Chinese hamster ovary cells with abnormally low levels of GSH: decreased ability to cleave endocytosed disulfide bonds. Journal of Cellular Physiology. 149: 60-5. PMID 1939347 DOI: 10.1002/Jcp.1041490109 |
0.335 |
|
| 1991 |
Lin YJ, Shen WC. Effects of deoxycholate on the transepithelial transport of sucrose and horseradish peroxidase in filter-grown Madin-Darby canine kidney (MDCK) cells. Pharmaceutical Research. 8: 498-501. PMID 1871046 DOI: 10.1023/A:1015855329071 |
0.353 |
|
| 1990 |
Du XT, Yeung A, Shen WC. A cytostatic protein isolated from the conditioned medium of mouse monocytic leukemia WEHI-3 cell cultures. Immunology Letters. 23: 119-24. PMID 2632368 DOI: 10.1016/0165-2478(89)90123-5 |
0.38 |
|
| 1990 |
Persiani S, Shen WC. Increase of poly(L-lysine) uptake but not fluid phase endocytosis in neuraminidase pretreated Madin-Darby canine kidney (MDCK) cells. Life Sciences. 45: 2605-10. PMID 2615558 DOI: 10.1016/0024-3205(89)90245-2 |
0.343 |
|
| 1990 |
Shen WC, Wan JS, Shen D. Proteolytic processing in a non-lysosomal compartment is required for transcytosis of protein-polylysine conjugates in cultured Madin-Darby canine kidney cells. Biochemical and Biophysical Research Communications. 166: 316-23. PMID 2405847 DOI: 10.1016/0006-291X(90)91947-Q |
0.361 |
|
| 1990 |
Wan JS, Persiani S, Shen WC. Transcellular processing of disulfide- and thioether-linked peroxidase--polylysine conjugates in cultured MDCK epithelial cells. Journal of Cellular Physiology. 145: 9-15. PMID 2211845 DOI: 10.1002/Jcp.1041450103 |
0.399 |
|
| 1990 |
Shen WC. Acid-sensitive dissociation between poly(lysine) and histamine-modified poly(glutamate) as a model for drug-releasing from carriers in endosomes Bba - General Subjects. 1034: 122-124. PMID 1691660 DOI: 10.1016/0304-4165(90)90163-Q |
0.351 |
|
| 1989 |
Persiani S, Ballou B, Shen WC, Ryser HJ, Reiland JM, Hakala TR. In vivo antitumor effect of methotrexate conjugated to a monoclonal IgM antibody specific for stage-specific embryonic antigen-1, on MH-15 mouse teratocarcinoma. Cancer Immunology, Immunotherapy : Cii. 29: 167-70. PMID 2567209 DOI: 10.1007/Bf00199991 |
0.305 |
|
| 1988 |
Ryser HJ, Mandel R, Hacobian A, Shen WC. Methotrexate-poly(lysine) as a selective agent for mutants of Chinese hamster ovary cells defective in endocytosis. Journal of Cellular Physiology. 135: 277-84. PMID 3372597 DOI: 10.1002/Jcp.1041350215 |
0.325 |
|
| 1988 |
Ryser HJ, Li W, Mandel R, Shen WC. Stable variant of LM fibroblast defective in fluid-phase but competent in receptor-mediated endocytosis. Journal of Cellular Physiology. 137: 490-6. PMID 2461380 DOI: 10.1002/Jcp.1041370314 |
0.341 |
|
| 1986 |
Li WD, Ryser HJ, Shen WC. Altered endocytosis in a mutant of LM fibroblasts defective in cell-cell fusion. Journal of Cellular Physiology. 126: 161-6. PMID 3944203 DOI: 10.1002/Jcp.1041260203 |
0.39 |
|
| 1984 |
Shen WC, Ryser HJ. Selective killing of Fc-receptor-bearing tumor cells through endocytosis of a drug-carrying immune complex. Proceedings of the National Academy of Sciences of the United States of America. 81: 1445-7. PMID 6369328 DOI: 10.1073/Pnas.81.5.1445 |
0.39 |
|
| 1984 |
Morad N, Ryser HJ, Shen WC. Binding sites and endocytosis of heparin and polylysine are changed when the two molecules are given as a complex to Chinese hamster ovary cells. Biochimica Et Biophysica Acta. 801: 117-26. PMID 6087917 DOI: 10.1016/0304-4165(84)90219-8 |
0.382 |
|
| 1982 |
Shen WC, Ryser HJ. cis-Aconityl spacer between daunomycin and macromolecular carriers: a model of pH-sensitive linkage releasing drug from a lysosomotropic conjugate. Biochemical and Biophysical Research Communications. 102: 1048-54. PMID 7306187 DOI: 10.1016/0006-291X(81)91644-2 |
0.327 |
|
| 1982 |
Ryser HJ, Drummond I, Shen WC. The cellular uptake of horseradish peroxidase and its poly(lysine) conjugate by cultured fibroblasts is qualitatively similar despite a 900-fold difference in rate. Journal of Cellular Physiology. 113: 167-78. PMID 6127344 DOI: 10.1002/Jcp.1041130126 |
0.376 |
|
| 1981 |
Shen WC, Ryser HJ. Selective protection against the cytotoxicity of methotrexate and methotrexate-poly(lysine) by thiamine pyrophosphate, heparin and leucovorin. Life Sciences. 28: 1209-14. PMID 6971979 DOI: 10.1016/0024-3205(81)90445-8 |
0.369 |
|
| 1980 |
Ryser HJ, Shen WC. Conjugation of methotrexate to poly (L-lysine) as a potential way to overcome drug resistance. Cancer. 45: 1207-11. PMID 7357512 DOI: 10.1002/1097-0142(19800315)45:5+<1207::Aid-Cncr2820451327>3.0.Co;2-M |
0.366 |
|
| 1978 |
Ryser HJ, Shen WC, Merk FB. Membrane transport of macromolecules: new carrier functions of proteins and poly(amino acids). Life Sciences. 22: 1253-60. PMID 351319 DOI: 10.1016/0024-3205(78)90094-2 |
0.397 |
|
| 1978 |
Ryser HJ, Shen WC. Conjugation of methotrexate to poly(L-lysine) increases drug transport and overcomes drug resistance in cultured cells. Proceedings of the National Academy of Sciences of the United States of America. 75: 3867-70. PMID 279001 DOI: 10.1073/Pnas.75.8.3867 |
0.378 |
|
| 1978 |
Shen WC, Ryser HJ. Conjugation of poly-L-lysine to albumin and horseradish peroxidase: a novel method of enhancing the cellular uptake of proteins. Proceedings of the National Academy of Sciences of the United States of America. 75: 1872-6. PMID 273916 DOI: 10.1073/Pnas.75.4.1872 |
0.366 |
|
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