| Year |
Citation |
Score |
| 2022 |
Xu H, Hurley LH. A First-in-Class Clinical G-Quadruplex-Targeting Drug. The Bench-to-Bedside Translation of the Fluoroquinolone QQ58 to CX-5461 (Pidnarulex). Bioorganic & Medicinal Chemistry Letters. 129016. PMID 36195286 DOI: 10.1016/j.bmcl.2022.129016 |
0.355 |
|
| 2020 |
King JJ, Irving KL, Evans CW, Chikhale RV, Becker R, Morris CJ, Peña Martinez CD, Schofield P, Christ D, Hurley LH, Waller ZAE, Iyer KS, Smith NM. DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells. Journal of the American Chemical Society. PMID 33253551 DOI: 10.1021/jacs.0c11708 |
0.351 |
|
| 2020 |
Miranti CK, Moore S, Kim Y, Chappeta VR, Wu K, De B, Gokhale V, Hurley LH, Reyes-Reyes EM. Erratum: Nucleolin represses transcription of the androgen receptor gene through a G-quadruplex. Oncotarget. 11: 2586. PMID 32655842 DOI: 10.18632/Oncotarget.27661 |
0.329 |
|
| 2020 |
Miranti CK, Moore S, Kim Y, Chappeta VR, Wu K, De B, Gokhale V, Hurley LH, Reyes-Reyes EM. Nucleolin represses transcription of the androgen receptor gene through a G-quadruplex. Oncotarget. 11: 1758-1776. PMID 32477465 DOI: 10.18632/Oncotarget.27589 |
0.362 |
|
| 2019 |
Montoya JJ, Turnidge MA, Wai DH, Patel AR, Lee DW, Gokhale V, Hurley LH, Arceci RJ, Wetmore C, Azorsa DO. In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells. Bmc Cancer. 19: 1251. PMID 31881855 DOI: 10.1186/S12885-019-6464-9 |
0.393 |
|
| 2019 |
Toshniwal P, Nguyen M, Guédin A, Viola H, Ho D, Kim Y, Bhatt U, Bond C, Hool L, Hurley LH, Mergny JL, Fear M, Wood F, Swaminathan Iyer K, Smith NM. TGF-β-induced fibrotic stress increases G-quadruplex formation in human fibroblasts. Febs Letters. PMID 31677274 DOI: 10.1002/1873-3468.13658 |
0.41 |
|
| 2019 |
Song JH, Kang HJ, Luevano LA, Gokhale V, Wu K, Pandey R, Sherry Chow HH, Hurley LH, Kraft AS. Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death. Cell Chemical Biology. PMID 31155510 DOI: 10.1016/J.Chembiol.2019.04.009 |
0.432 |
|
| 2019 |
Ferdosi SR, Bollam S, Peng S, Taylor B, Gokhale V, Hurley L, Berens M, Dhruv H. Abstract 5226: Non-canonical functions of TERT in glioblastoma pathobiology Cancer Research. 79: 5226-5226. DOI: 10.1158/1538-7445.Sabcs18-5226 |
0.304 |
|
| 2019 |
Ferdosi S, Taylor B, Bollam S, Gokhale V, Hurley L, Dhruv H, Berens M. CBMT-23. NON-CANONICAL FUNCTIONS OF TERT IN GLIOBLASTOMA Neuro-Oncology. 21: vi38-vi38. DOI: 10.1093/Neuonc/Noz175.145 |
0.309 |
|
| 2018 |
Ho D, Kretzmann JA, Norret M, Toshniwal P, Veder JP, Jiang H, Guagliardo P, Munshi AM, Chawla R, Evans CW, Clemons TD, Nguyen M, Kretzmann AL, Blythe AJ, Saunders M, ... ... Hurley LH, et al. Intracellular speciation of gold nanorods alters the conformational dynamics of genomic DNA. Nature Nanotechnology. PMID 30297819 DOI: 10.1038/S41565-018-0272-2 |
0.584 |
|
| 2018 |
Amato J, Madanayake TW, Iaccarino N, Novellino E, Randazzo A, Hurley LH, Pagano B. HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation? Chemical Communications (Cambridge, England). 54: 9442-9445. PMID 30079419 DOI: 10.1039/C8Cc03614D |
0.415 |
|
| 2018 |
Turnidge MA, Wai DH, Patel A, Montoya JJ, Lee DW, Hurley LH, Gokhale V, Arceci RJ, Azorsa DO. Abstract B04: Direct downregulation of MYC in AML cells using promoter G-quadruplex interacting small molecules Cancer Research. 78. DOI: 10.1158/1538-7445.Pedca17-B04 |
0.398 |
|
| 2018 |
Song JH, Luevano LA, Kang H, Gokhale V, Hurley LH, Kraft AS. Abstract 4841: Prostate cancer cell death triggered by a small molecule interacting with the hTERT G-quadruplex Cancer Research. 78: 4841-4841. DOI: 10.1158/1538-7445.Am2018-4841 |
0.407 |
|
| 2018 |
Bollam SR, Kang H, Peng S, Gokhale V, Hurley L, Berens M, Dhruv H. Abstract 4798: Targeting hTERT for treatment of glioblastoma (GBM) Cancer Research. 78: 4798-4798. DOI: 10.1158/1538-7445.Am2018-4798 |
0.43 |
|
| 2017 |
Onel B, Carver M, Agrawal P, Hurley LH, Yang D. The 3'-End Region of the Human PDGFR-β Core Promoter Nuclease Hypersensitive Element Forms a Mixture of Two Unique End-Insertion G-Quadruplexes. Biochimica Et Biophysica Acta. PMID 29288770 DOI: 10.1016/J.Bbagen.2017.12.011 |
0.405 |
|
| 2017 |
Weldon C, Dacanay JG, Gokhale V, Boddupally PVL, Behm-Ansmant I, Burley GA, Branlant C, Hurley LH, Dominguez C, Eperon IC. Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X. Nucleic Acids Research. PMID 29156002 DOI: 10.1093/Nar/Gkx1122 |
0.384 |
|
| 2017 |
Kendrick S, Muranyi A, Gokhale V, Hurley LH, Rimsza LM. Simultaneous Drug Targeting of the Promoter MYC G-Quadruplex and BCL2 i-Motif in Diffuse Large B-Cell Lymphoma Delays Tumor Growth. Journal of Medicinal Chemistry. PMID 28605593 DOI: 10.1021/Acs.Jmedchem.7B00298 |
0.76 |
|
| 2017 |
Kaiser C, Van Ert N, Agrawal P, Chawla R, Yang D, Hurley LH. Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression. Journal of the American Chemical Society. PMID 28570076 DOI: 10.1021/Jacs.7B02046 |
0.674 |
|
| 2017 |
Brown R, Wang T, Chappeta VR, Wu G, Onel B, Chawla R, Quijada H, Camp SM, Chiang ET, Lassiter Q, Lee C, Phanse S, Turnidge M, Zhao P, Garcia JGN, ... ... Hurley LH, et al. The Consequences of Overlapping G-Quadruplexes and i-Motifs in the PDGFR-β Core Promoter NHE Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting of Both Structures by Small Molecules to Downregulate Gene Expression. Journal of the American Chemical Society. PMID 28471683 DOI: 10.1021/Jacs.6B10028 |
0.615 |
|
| 2017 |
Onel B, Agrawal P, Carver M, Hurley LH, Yang D. Abstract 5230: Targeting two unique end-insertion G-quadruplexes formed in the 3′-end of the PDGFR-β core promoter nuclease hypersensitive element with ellipticine analog Cancer Research. 77: 5230-5230. DOI: 10.1158/1538-7445.Am2017-5230 |
0.372 |
|
| 2017 |
Turnidge MA, Patel A, Montoya JJ, Lee DW, Wai DH, Gokhale V, Hurley L, Arceci RJ, Azorsa DO. Abstract 5181: Targeted knockdown of MYC in AML cells using G-quadruplex interacting small molecules Cancer Research. 77: 5181-5181. DOI: 10.1158/1538-7445.Am2017-5181 |
0.429 |
|
| 2017 |
Dhruv H, Bollam S, Kang H, Peng S, Gokhale V, Hurley L, Berens M. OS01.3 mtTERT promoter as a target for treatment of Glioblastoma Neuro-Oncology. 19: iii1-iii1. DOI: 10.1093/Neuonc/Nox036.002 |
0.438 |
|
| 2016 |
Weldon C, Behm-Ansmant I, Hurley LH, Burley GA, Branlant C, Eperon IC, Dominguez C. Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA. Nature Chemical Biology. PMID 27820800 DOI: 10.1038/Nchembio.2228 |
0.304 |
|
| 2016 |
Sutherland C, Cui Y, Mao H, Hurley LH. A Mechanosensor Mechanism Controls the G-Quadruplex/i-Motif Molecular Switch in the MYC Promoter NHE III1. Journal of the American Chemical Society. PMID 27669098 DOI: 10.1021/Jacs.6B09196 |
0.43 |
|
| 2016 |
Kang HJ, Cui Y, Yin H, Scheid A, Hendricks WP, Schmidt J, Sekulic A, Kong D, Trent JM, Gokhale V, Mao H, Hurley LH. A Pharmacological Chaperone Molecule Induces Cancer Cell Death by Restoring Tertiary DNA Structures in Mutant hTERT Promoters. Journal of the American Chemical Society. PMID 27643954 DOI: 10.1021/Jacs.6B07598 |
0.428 |
|
| 2016 |
Kendrick S, Kang HJ, Alam MP, Madathil MM, Agrawal P, Gokhale V, Yang D, Hecht SM, Hurley LH. Correction to "The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure". Journal of the American Chemical Society. PMID 27571358 DOI: 10.1021/jacs.6b07292 |
0.722 |
|
| 2016 |
Roy B, Talukder P, Kang HJ, Tsuen SS, Alam MP, Hurley LH, Hecht SM. Interaction of Individual Structural Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA. Journal of the American Chemical Society. PMID 27483029 DOI: 10.1021/Jacs.6B05036 |
0.445 |
|
| 2016 |
Kendrick SL, Gokhale V, Hurley L, Rimsza L. Concurrent Targeting of BCL2 and MYC Transcription Leads to Chemo-Sensitization of Dual-Expressing Diffuse Large B-Cell Lymphoma In Vivo Blood. 128: 4090-4090. DOI: 10.1182/Blood.V128.22.4090.4090 |
0.689 |
|
| 2016 |
Turnidge M, Montoya JJ, Patel A, Lee DW, Aleem E, Wai DH, Hurley LH, Gokhale V, Arceci RJ, Azorsa DO. Abstract 3766: Targeting promoter regions of c-Myc and Bcl-2 in AML cells using G-quadruplex interacting drugs Cancer Research. 76: 3766-3766. DOI: 10.1158/1538-7445.Am2016-3766 |
0.435 |
|
| 2016 |
Lin C, Agrawal P, Chen Y, Kalarn S, Deng N, Hurley L, Yang D. Abstract 3090: Molecular structure of the major G-quadruplex formed in the PDGFR-β promoter nuclease hypersensitivity element and its binding with small molecules Cancer Research. 76: 3090-3090. DOI: 10.1158/1538-7445.Am2016-3090 |
0.434 |
|
| 2016 |
Onel B, Agrawal P, Carver M, Brown R, Hurley L, Yang D. Abstract 3089: A novel G-quadruplex formed in the PDGFR-β promoter that is selectively targeted by a small molecule to repress transcription Cancer Research. 76: 3089-3089. DOI: 10.1158/1538-7445.Am2016-3089 |
0.449 |
|
| 2015 |
Sutherland C, Hurley L. Abstract 2078: A functional role for the MYC i-motif in transcription Cancer Research. 75: 2078-2078. DOI: 10.1158/1538-7445.Am2015-2078 |
0.382 |
|
| 2014 |
Cui Y, Koirala D, Kang H, Dhakal S, Yangyuoru P, Hurley LH, Mao H. Molecular population dynamics of DNA structures in a bcl-2 promoter sequence is regulated by small molecules and the transcription factor hnRNP LL. Nucleic Acids Research. 42: 5755-64. PMID 24609386 DOI: 10.1093/Nar/Gku185 |
0.409 |
|
| 2014 |
Kang HJ, Kendrick S, Hecht SM, Hurley LH. The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules. Journal of the American Chemical Society. 136: 4172-85. PMID 24559432 DOI: 10.1021/Ja4109352 |
0.732 |
|
| 2014 |
Kendrick S, Kang HJ, Alam MP, Madathil MM, Agrawal P, Gokhale V, Yang D, Hecht SM, Hurley LH. The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure. Journal of the American Chemical Society. 136: 4161-71. PMID 24559410 DOI: 10.1021/Ja410934B |
0.759 |
|
| 2013 |
Siddiqui-Jain A, Hurley LH. DNA structure: Visualizing the quadruplex. Nature Chemistry. 5: 153-5. PMID 23422553 DOI: 10.1038/Nchem.1587 |
0.453 |
|
| 2013 |
Kaiser CE, Gokhale V, Yang D, Hurley LH. Gaining insights into the small molecule targeting of the G-quadruplex in the c-MYC promoter using NMR and an allele-specific transcriptional assay. Topics in Current Chemistry. 330: 1-21. PMID 22752577 DOI: 10.1007/128_2012_333 |
0.486 |
|
| 2013 |
Kendrick SL, Loftin C, Rivera X, Hurley LH, Rimsza LM. Novel Targeting Of BCL2 and MYC DNA Secondary Structures In Diffuse Large B-Cell Lymphoma (DLBCL) Blood. 122: 2532-2532. DOI: 10.1182/Blood.V122.21.2532.2532 |
0.397 |
|
| 2012 |
Chen Y, Agrawal P, Brown RV, Hatzakis E, Hurley L, Yang D. The major G-quadruplex formed in the human platelet-derived growth factor receptor β promoter adopts a novel broken-strand structure in K+ solution. Journal of the American Chemical Society. 134: 13220-3. PMID 22866911 DOI: 10.1021/Ja305764D |
0.42 |
|
| 2012 |
Boddupally PV, Hahn S, Beman C, De B, Brooks TA, Gokhale V, Hurley LH. Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter. Journal of Medicinal Chemistry. 55: 6076-86. PMID 22691117 DOI: 10.1021/Jm300282C |
0.443 |
|
| 2012 |
Yu Z, Gaerig V, Cui Y, Kang H, Gokhale V, Zhao Y, Hurley LH, Mao H. Tertiary DNA structure in the single-stranded hTERT promoter fragment unfolds and refolds by parallel pathways via cooperative or sequential events. Journal of the American Chemical Society. 134: 5157-64. PMID 22372563 DOI: 10.1021/Ja210399H |
0.47 |
|
| 2011 |
Dai J, Carver M, Hurley LH, Yang D. Solution structure of a 2:1 quindoline-c-MYC G-quadruplex: insights into G-quadruplex-interactive small molecule drug design. Journal of the American Chemical Society. 133: 17673-80. PMID 21967482 DOI: 10.1021/Ja205646Q |
0.481 |
|
| 2011 |
Brown RV, Danford FL, Gokhale V, Hurley LH, Brooks TA. Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex. The Journal of Biological Chemistry. 286: 41018-27. PMID 21956115 DOI: 10.1074/Jbc.M111.274720 |
0.514 |
|
| 2011 |
Balasubramanian S, Hurley LH, Neidle S. Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nature Reviews. Drug Discovery. 10: 261-75. PMID 21455236 DOI: 10.1038/Nrd3428 |
0.455 |
|
| 2011 |
Brown RV, Hurley LH. DNA acting like RNA. Biochemical Society Transactions. 39: 635-40. PMID 21428953 DOI: 10.1042/Bst0390635 |
0.417 |
|
| 2011 |
Brown RV, Hurley LH, Brooks TA. Abstract 4422: Direct demonstration of c-MYC G-quadruplex stabilization in vitro: elucidating the CA46 system Cancer Research. 71: 4422-4422. DOI: 10.1158/1538-7445.Am2011-4422 |
0.453 |
|
| 2010 |
Kendrick S, Hurley LH. The role of G-quadruplex/i-motif secondary structures as cis-acting regulatory elements. Pure and Applied Chemistry. Chimie Pure Et Appliquee. 82: 1609-1621. PMID 21796223 DOI: 10.1351/Pac-Con-09-09-29 |
0.757 |
|
| 2010 |
Brooks TA, Hurley LH. Targeting MYC Expression through G-Quadruplexes. Genes & Cancer. 1: 641-649. PMID 21113409 DOI: 10.1177/1947601910377493 |
0.51 |
|
| 2010 |
González V, Hurley LH. The C-terminus of nucleolin promotes the formation of the c-MYC G-quadruplex and inhibits c-MYC promoter activity. Biochemistry. 49: 9706-14. PMID 20932061 DOI: 10.1021/Bi100509S |
0.414 |
|
| 2010 |
Brooks TA, Kendrick S, Hurley L. Making sense of G-quadruplex and i-motif functions in oncogene promoters. The Febs Journal. 277: 3459-69. PMID 20670278 DOI: 10.1111/J.1742-4658.2010.07759.X |
0.765 |
|
| 2010 |
Dai J, Hatzakis E, Hurley LH, Yang D. I-motif structures formed in the human c-MYC promoter are highly dynamic--insights into sequence redundancy and I-motif stability. Plos One. 5: e11647. PMID 20657837 DOI: 10.1371/Journal.Pone.0011647 |
0.406 |
|
| 2010 |
Dietrich J, Hulme C, Hurley LH. The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: a structural analysis of the binding interactions of Gleevec, Nexavar, and BIRB-796. Bioorganic & Medicinal Chemistry. 18: 5738-48. PMID 20621496 DOI: 10.1016/J.Bmc.2010.05.063 |
0.711 |
|
| 2010 |
Qin Y, Fortin JS, Tye D, Gleason-Guzman M, Brooks TA, Hurley LH. Molecular cloning of the human platelet-derived growth factor receptor beta (PDGFR-beta) promoter and drug targeting of the G-quadruplex-forming region to repress PDGFR-beta expression. Biochemistry. 49: 4208-19. PMID 20377208 DOI: 10.1021/Bi100330W |
0.695 |
|
| 2010 |
Sun D, Hurley LH. Biochemical techniques for the characterization of G-quadruplex structures: EMSA, DMS footprinting, and DNA polymerase stop assay. Methods in Molecular Biology (Clifton, N.J.). 608: 65-79. PMID 20012416 DOI: 10.1007/978-1-59745-363-9_5 |
0.5 |
|
| 2010 |
Dietrich J, Gokhale V, Wang X, Hurley LH, Flynn GA. Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors. Bioorganic & Medicinal Chemistry. 18: 292-304. PMID 19962319 DOI: 10.1016/J.Bmc.2009.10.055 |
0.69 |
|
| 2010 |
González V, Hurley LH. The c-MYC NHE III(1): function and regulation. Annual Review of Pharmacology and Toxicology. 50: 111-29. PMID 19922264 DOI: 10.1146/Annurev.Pharmtox.48.113006.094649 |
0.427 |
|
| 2010 |
Hurley NE, Schildmeyer LA, Bosworth KA, Sakurai Y, Eskin SG, Hurley LH, McIntire LV. Modulating the functional contributions of c-Myc to the human endothelial cell cyclic strain response. Journal of Vascular Research. 47: 80-90. PMID 19729955 DOI: 10.1159/000235928 |
0.324 |
|
| 2010 |
Kendrick S, Hurley L. Abstract LB-46: Chemo-sensitization by modulation of Bcl-2 expression: The first example of an i-motif interactive small molecule that modulates gene expression Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-46 |
0.733 |
|
| 2009 |
Kendrick S, Akiyama Y, Hecht SM, Hurley LH. The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern. Journal of the American Chemical Society. 131: 17667-76. PMID 19908860 DOI: 10.1021/Ja9076292 |
0.768 |
|
| 2009 |
Brooks TA, Hurley LH. The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics. Nature Reviews. Cancer. 9: 849-61. PMID 19907434 DOI: 10.1038/Nrc2733 |
0.45 |
|
| 2009 |
Shaw AY, Henderson MC, Flynn G, Samulitis B, Han H, Stratton SP, Chow HH, Hurley LH, Dorr RT. Characterization of novel diaryl oxazole-based compounds as potential agents to treat pancreatic cancer. The Journal of Pharmacology and Experimental Therapeutics. 331: 636-47. PMID 19657049 DOI: 10.1124/Jpet.109.156406 |
0.309 |
|
| 2009 |
Palumbo SL, Ebbinghaus SW, Hurley LH. Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands. Journal of the American Chemical Society. 131: 10878-91. PMID 19601575 DOI: 10.1021/Ja902281D |
0.803 |
|
| 2009 |
González V, Guo K, Hurley L, Sun D. Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein. The Journal of Biological Chemistry. 284: 23622-35. PMID 19581307 DOI: 10.1074/Jbc.M109.018028 |
0.655 |
|
| 2009 |
Dexheimer TS, Carey SS, Zuohe S, Gokhale VM, Hu X, Murata LB, Maes EM, Weichsel A, Sun D, Meuillet EJ, Montfort WR, Hurley LH. NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1). Molecular Cancer Therapeutics. 8: 1363-77. PMID 19435876 DOI: 10.1158/1535-7163.Mct-08-1093 |
0.726 |
|
| 2009 |
Dai J, Ambrus A, Hurley LH, Yang D. A direct and nondestructive approach to determine the folding structure of the I-motif DNA secondary structure by NMR. Journal of the American Chemical Society. 131: 6102-4. PMID 19400591 DOI: 10.1021/Ja900967R |
0.442 |
|
| 2009 |
Sun D, Hurley LH. The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression. Journal of Medicinal Chemistry. 52: 2863-74. PMID 19385599 DOI: 10.1021/Jm900055S |
0.495 |
|
| 2009 |
Uribe DJ, Guo K, Shin Y, Hurley L, Sun D. Abstract A203: Heterogeneous nuclear ribonucleoprotein K (hnRNP K) binds to the vascular endothelial growth factor (VEGF) promoter and plays a role in its transcriptional control Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-A203 |
0.584 |
|
| 2008 |
Guo K, Gokhale V, Hurley LH, Sun D. Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene. Nucleic Acids Research. 36: 4598-608. PMID 18614607 DOI: 10.1093/Nar/Gkn380 |
0.675 |
|
| 2008 |
Sun D, Liu WJ, Guo K, Rusche JJ, Ebbinghaus S, Gokhale V, Hurley LH. The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents. Molecular Cancer Therapeutics. 7: 880-9. PMID 18413801 DOI: 10.1158/1535-7163.Mct-07-2119 |
0.665 |
|
| 2008 |
Qin Y, Hurley LH. Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions. Biochimie. 90: 1149-71. PMID 18355457 DOI: 10.1016/J.Biochi.2008.02.020 |
0.508 |
|
| 2008 |
Palumbo SL, Memmott RM, Uribe DJ, Krotova-Khan Y, Hurley LH, Ebbinghaus SW. A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity. Nucleic Acids Research. 36: 1755-69. PMID 18252774 DOI: 10.1093/Nar/Gkm1069 |
0.803 |
|
| 2008 |
Cashman DJ, Buscaglia R, Freyer MW, Dettler J, Hurley LH, Lewis EA. Molecular modeling and biophysical analysis of the c-MYC NHE-III1 silencer element. Journal of Molecular Modeling. 14: 93-101. PMID 18087730 DOI: 10.1007/S00894-007-0254-Z |
0.479 |
|
| 2007 |
Qin Y, Rezler EM, Gokhale V, Sun D, Hurley LH. Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4. Nucleic Acids Research. 35: 7698-713. PMID 17984069 DOI: 10.1093/Nar/Gkm538 |
0.504 |
|
| 2007 |
Guo K, Pourpak A, Beetz-Rogers K, Gokhale V, Sun D, Hurley LH. Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene. Journal of the American Chemical Society. 129: 10220-8. PMID 17672459 DOI: 10.1021/Ja072185G |
0.663 |
|
| 2007 |
Zhu M, Gokhale VM, Szabo L, Munoz RM, Baek H, Bashyam S, Hurley LH, Von Hoff DD, Han H. Identification of a novel inhibitor of urokinase-type plasminogen activator. Molecular Cancer Therapeutics. 6: 1348-56. PMID 17431113 DOI: 10.1158/1535-7163.Mct-06-0520 |
0.323 |
|
| 2007 |
Freyer MW, Buscaglia R, Kaplan K, Cashman D, Hurley LH, Lewis EA. Biophysical studies of the c-MYC NHE III1 promoter: model quadruplex interactions with a cationic porphyrin. Biophysical Journal. 92: 2007-15. PMID 17172304 DOI: 10.1529/Biophysj.106.097246 |
0.371 |
|
| 2006 |
Warner SL, Munoz RM, Stafford P, Koller E, Hurley LH, Von Hoff DD, Han H. Comparing Aurora A and Aurora B as molecular targets for growth inhibition of pancreatic cancer cells. Molecular Cancer Therapeutics. 5: 2450-8. PMID 17041088 DOI: 10.1158/1535-7163.Mct-06-0202 |
0.56 |
|
| 2006 |
Dai J, Chen D, Jones RA, Hurley LH, Yang D. NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region. Nucleic Acids Research. 34: 5133-44. PMID 16998187 DOI: 10.1093/Nar/Gkl610 |
0.461 |
|
| 2006 |
Yang D, Hurley LH. Structure of the biologically relevant G-quadruplex in the c-MYC promoter. Nucleosides, Nucleotides & Nucleic Acids. 25: 951-68. PMID 16901825 DOI: 10.1080/15257770600809913 |
0.473 |
|
| 2006 |
Warner SL, Bashyam S, Vankayalapati H, Bearss DJ, Han H, Mahadevan D, Von Hoff DD, Hurley LH. Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach. Molecular Cancer Therapeutics. 5: 1764-73. PMID 16891462 DOI: 10.1158/1535-7163.Mct-05-0524 |
0.587 |
|
| 2006 |
Hurley LH, Von Hoff DD, Siddiqui-Jain A, Yang D. Drug targeting of the c-MYC promoter to repress gene expression via a G-quadruplex silencer element. Seminars in Oncology. 33: 498-512. PMID 16890804 DOI: 10.1053/J.Seminoncol.2006.04.012 |
0.459 |
|
| 2006 |
Dexheimer TS, Sun D, Hurley LH. Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter. Journal of the American Chemical Society. 128: 5404-15. PMID 16620112 DOI: 10.1021/Ja0563861 |
0.726 |
|
| 2005 |
Lim JK, Rice WG, Schwaebe MK, Siddiqui-Jain A, Trent KB, Whitten JP, Hurley LH, von Hoff DD. Clinical development of CX-3543, a novel multi-targeting antitumor agent. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 3206. PMID 27946547 DOI: 10.1200/Jco.2005.23.16_Suppl.3206 |
0.381 |
|
| 2005 |
Liu W, Sun D, Hurley LH. Binding of G-quadruplex-interactive agents to distinct G-quadruplexes induces different biological effects in MiaPaCa cells. Nucleosides, Nucleotides & Nucleic Acids. 24: 1801-15. PMID 16438049 DOI: 10.1080/15257770500267238 |
0.399 |
|
| 2005 |
Gerner EW, Ignatenko NA, Lance P, Hurley LH. A comprehensive strategy to combat colon cancer targeting the adenomatous polyposis coli tumor suppressor gene. Annals of the New York Academy of Sciences. 1059: 97-105. PMID 16382048 DOI: 10.1196/Annals.1339.033 |
0.333 |
|
| 2005 |
De Armond R, Wood S, Sun D, Hurley LH, Ebbinghaus SW. Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter. Biochemistry. 44: 16341-50. PMID 16331995 DOI: 10.1021/Bi051618U |
0.326 |
|
| 2005 |
Fellows IM, Schwaebe M, Dexheimer TS, Vankayalapati H, Gleason-Guzman M, Whitten JP, Hurley LH. Determination of the importance of the stereochemistry of psorospermin in topoisomerase II-induced alkylation of DNA and in vitro and in vivo biological activity. Molecular Cancer Therapeutics. 4: 1729-39. PMID 16275994 DOI: 10.1158/1535-7163.Mct-05-0183 |
0.635 |
|
| 2005 |
Sun D, Guo K, Rusche JJ, Hurley LH. Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents. Nucleic Acids Research. 33: 6070-80. PMID 16239639 DOI: 10.1093/Nar/Gki917 |
0.653 |
|
| 2005 |
Rezler EM, Seenisamy J, Bashyam S, Kim MY, White E, Wilson WD, Hurley LH. Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure. Journal of the American Chemical Society. 127: 9439-47. PMID 15984871 DOI: 10.1021/Ja0505088 |
0.429 |
|
| 2005 |
Heald RA, Dexheimer TS, Vankayalapati H, Siddiqui-Jain A, Szabo LZ, Gleason-Guzman MC, Hurley LH. Conformationally restricted analogues of psorospermin: design, synthesis, and bioactivity of natural-product-related bisfuranoxanthones. Journal of Medicinal Chemistry. 48: 2993-3004. PMID 15828838 DOI: 10.1021/Jm049299C |
0.687 |
|
| 2005 |
Seenisamy J, Bashyam S, Gokhale V, Vankayalapati H, Sun D, Siddiqui-Jain A, Streiner N, Shin-Ya K, White E, Wilson WD, Hurley LH. Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure. Journal of the American Chemical Society. 127: 2944-59. PMID 15740131 DOI: 10.1021/Ja0444482 |
0.474 |
|
| 2005 |
Grand CL, Powell TJ, Nagle RB, Bearss DJ, Tye D, Gleason-Guzman M, Hurley LH. Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue. Proceedings of the National Academy of Sciences of the United States of America. 102: 516. PMID 15696627 DOI: 10.1073/Pnas.0408999101 |
0.78 |
|
| 2004 |
Zhilina ZV, Ziemba AJ, Trent JO, Reed MW, Gorn V, Zhou Q, Duan W, Hurley L, Ebbinghaus SW. Synthesis and evaluation of a triplex-forming oligonucleotide-pyrrolobenzodiazepine conjugate. Bioconjugate Chemistry. 15: 1182-92. PMID 15546183 DOI: 10.1021/Bc0498673 |
0.368 |
|
| 2004 |
Mehta AK, Shayo Y, Vankayalapati H, Hurley LH, Schaefer J. Structure of a quinobenzoxazine--G-quadruplex complex by REDOR NMR. Biochemistry. 43: 11953-8. PMID 15379535 DOI: 10.1021/Bi049697H |
0.392 |
|
| 2004 |
Seenisamy J, Rezler EM, Powell TJ, Tye D, Gokhale V, Joshi CS, Siddiqui-Jain A, Hurley LH. The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4. Journal of the American Chemical Society. 126: 8702-9. PMID 15250722 DOI: 10.1021/Ja040022B |
0.457 |
|
| 2004 |
Grand CL, Powell TJ, Nagle RB, Bearss DJ, Tye D, Gleason-Guzman M, Hurley LH. Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue. Proceedings of the National Academy of Sciences of the United States of America. 101: 6140-5. PMID 15079086 DOI: 10.1073/Pnas.0400460101 |
0.786 |
|
| 2004 |
Shammas MA, Shmookler Reis RJ, Li C, Koley H, Hurley LH, Anderson KC, Munshi NC. Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 770-6. PMID 14760100 DOI: 10.1158/1078-0432.Ccr-0793-03 |
0.342 |
|
| 2004 |
Warner S, Vankayalapati H, Bashyam S, Grand C, Han H, Von Hoff D, Hurley L, Bearss D. 126 Development of a new series of tricyclic pyrimido-indole inhibitors targeting Aurora kinases European Journal of Cancer Supplements. 2: 41. DOI: 10.1016/S1359-6349(04)80134-4 |
0.74 |
|
| 2003 |
Weisman-Shomer P, Cohen E, Hershco I, Khateb S, Wolfovitz-Barchad O, Hurley LH, Fry M. The cationic porphyrin TMPyP4 destabilizes the tetraplex form of the fragile X syndrome expanded sequence d(CGG)n. Nucleic Acids Research. 31: 3963-70. PMID 12853612 DOI: 10.1093/Nar/Gkg453 |
0.311 |
|
| 2003 |
Kim MY, Na Y, Vankayalapati H, Gleason-Guzman M, Hurley LH. Design, synthesis, and evaluation of psorospermin/quinobenzoxazine hybrids as structurally novel antitumor agents. Journal of Medicinal Chemistry. 46: 2958-72. PMID 12825936 DOI: 10.1021/Jm030096I |
0.419 |
|
| 2003 |
Kim MY, Gleason-Guzman M, Izbicka E, Nishioka D, Hurley LH. The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures. Cancer Research. 63: 3247-56. PMID 12810655 |
0.379 |
|
| 2003 |
Kim MY, Duan W, Gleason-Guzman M, Hurley LH. Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes. Journal of Medicinal Chemistry. 46: 571-83. PMID 12570378 DOI: 10.1021/Jm0203377 |
0.395 |
|
| 2003 |
Rezler EM, Bearss DJ, Hurley LH. Telomere inhibition and telomere disruption as processes for drug targeting. Annual Review of Pharmacology and Toxicology. 43: 359-79. PMID 12540745 DOI: 10.1146/Annurev.Pharmtox.43.100901.135733 |
0.414 |
|
| 2002 |
Grand CL, Han H, Muñoz RM, Weitman S, Von Hoff DD, Hurley LH, Bearss DJ. The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo. Molecular Cancer Therapeutics. 1: 565-73. PMID 12479216 |
0.795 |
|
| 2002 |
Siddiqui-Jain A, Grand CL, Bearss DJ, Hurley LH. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proceedings of the National Academy of Sciences of the United States of America. 99: 11593-8. PMID 12195017 DOI: 10.1073/Pnas.182256799 |
0.815 |
|
| 2002 |
Rezler EM, Bearss DJ, Hurley LH. Telomeres and telomerases as drug targets. Current Opinion in Pharmacology. 2: 415-23. PMID 12127874 DOI: 10.1016/S1471-4892(02)00182-0 |
0.456 |
|
| 2002 |
Hurley LH. DNA and its associated processes as targets for cancer therapy. Nature Reviews. Cancer. 2: 188-200. PMID 11990855 DOI: 10.1038/Nrc749 |
0.355 |
|
| 2002 |
Kim MY, Vankayalapati H, Shin-Ya K, Wierzba K, Hurley LH. Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex. Journal of the American Chemical Society. 124: 2098-9. PMID 11878947 DOI: 10.1021/Ja017308Q |
0.433 |
|
| 2002 |
Herzig MC, Rodriguez KA, Trevino AV, Dziegielewski J, Arnett B, Hurley L, Woynarowski JM. The genome factor in region-specific DNA damage: the DNA-reactive drug U-78779 prefers mixed A/T-G/C sequences at the nucleotide level but is region-specific for long pure AT islands at the genomic level. Biochemistry. 41: 1545-55. PMID 11814348 DOI: 10.1021/Bi011907S |
0.414 |
|
| 2001 |
Hurley LH, Zewail-Foote M. The antitumor agent ecteinascidin 743: characterization of its covalent DNA adducts and chemical stability. Advances in Experimental Medicine and Biology. 500: 289-99. PMID 11764956 DOI: 10.1007/978-1-4615-0667-6_46 |
0.404 |
|
| 2001 |
Shi DF, Wheelhouse RT, Sun D, Hurley LH. Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. Journal of Medicinal Chemistry. 44: 4509-23. PMID 11741471 DOI: 10.1021/Jm010246U |
0.723 |
|
| 2001 |
Zewail-Foote M, Li VS, Kohn H, Bearss D, Guzman M, Hurley LH. The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent. Chemistry & Biology. 8: 1033-49. PMID 11731295 DOI: 10.1016/S1074-5521(01)00071-0 |
0.381 |
|
| 2001 |
Hurley LH. Secondary DNA structures as molecular targets for cancer therapeutics. Biochemical Society Transactions. 29: 692-6. PMID 11709056 DOI: 10.1042/0300-5127:0290692 |
0.516 |
|
| 2001 |
Han H, Langley DR, Rangan A, Hurley LH. Selective interactions of cationic porphyrins with G-quadruplex structures. Journal of the American Chemical Society. 123: 8902-13. PMID 11552797 DOI: 10.1021/Ja002179J |
0.443 |
|
| 2001 |
Sun D, Hurley LH. Targeting telomeres and telomerase. Methods in Enzymology. 340: 573-92. PMID 11494871 DOI: 10.1016/S0076-6879(01)40443-5 |
0.385 |
|
| 2001 |
Zhou Q, Duan W, Simmons D, Shayo Y, Raymond MA, Dorr RT, Hurley LH. Design and synthesis of a novel DNA-DNA interstrand adenine-guanine cross-linking agent. Journal of the American Chemical Society. 123: 4865-6. PMID 11457309 DOI: 10.1021/Ja005658R |
0.383 |
|
| 2001 |
Zewail-Foote M, Hurley LH. Differential rates of reversibility of ecteinascidin 743-DNA covalent adducts from different sequences lead to migration to favored bonding sites. Journal of the American Chemical Society. 123: 6485-95. PMID 11439034 DOI: 10.1021/Ja004023P |
0.407 |
|
| 2001 |
Rangan A, Fedoroff OY, Hurley LH. Induction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule. The Journal of Biological Chemistry. 276: 4640-6. PMID 11035006 DOI: 10.1074/Jbc.M005962200 |
0.525 |
|
| 2000 |
Bearss DJ, Hurley LH, Von Hoff DD. Telomere maintenance mechanisms as a target for drug development. Oncogene. 19: 6632-41. PMID 11426649 DOI: 10.1038/Sj.Onc.1204092 |
0.328 |
|
| 2000 |
Fedoroff OY, Rangan A, Chemeris VV, Hurley LH. Cationic porphyrins promote the formation of i-motif DNA and bind peripherally by a nonintercalative mechanism. Biochemistry. 39: 15083-90. PMID 11106486 DOI: 10.1021/Bi001528J |
0.507 |
|
| 2000 |
Yu H, Kwok Y, Hurley LH, Kerwin SM. Efficient, Mg(2+)-dependent photochemical DNA cleavage by the antitumor quinobenzoxazine (S)-A-62176. Biochemistry. 39: 10236-46. PMID 10956013 DOI: 10.1021/Bi001103X |
0.421 |
|
| 2000 |
Han H, Bennett RJ, Hurley LH. Inhibition of unwinding of G-quadruplex structures by Sgs1 helicase in the presence of N,N'-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic diimide, a G-quadruplex-interactive ligand. Biochemistry. 39: 9311-6. PMID 10924124 DOI: 10.1021/Bi000482R |
0.498 |
|
| 2000 |
Raymond E, Soria JC, Izbicka E, Boussin F, Hurley L, Von Hoff DD. DNA G-quadruplexes, telomere-specific proteins and telomere-associated enzymes as potential targets for new anticancer drugs. Investigational New Drugs. 18: 123-37. PMID 10857992 DOI: 10.1023/A:1006373812586 |
0.36 |
|
| 2000 |
Han H, Hurley LH. G-quadruplex DNA: a potential target for anti-cancer drug design. Trends in Pharmacological Sciences. 21: 136-42. PMID 10740289 DOI: 10.1016/S0165-6147(00)01457-7 |
0.499 |
|
| 2000 |
Hurley LH, Wheelhouse RT, Sun D, Kerwin SM, Salazar M, Fedoroff OY, Han FX, Han H, Izbicka E, Von Hoff DD. G-quadruplexes as targets for drug design. Pharmacology & Therapeutics. 85: 141-58. PMID 10739869 DOI: 10.1016/S0163-7258(99)00068-6 |
0.757 |
|
| 1999 |
Kwok Y, Sun D, Clement JJ, Hurley LH. The quinobenzoxazines: relationship between DNA binding and biological activity. Anti-Cancer Drug Design. 14: 443-50. PMID 10766299 |
0.304 |
|
| 1999 |
Zewail-Foote M, Hurley LH. Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove. Journal of Medicinal Chemistry. 42: 2493-7. PMID 10411470 DOI: 10.1021/Jm990241L |
0.364 |
|
| 1999 |
Kwok Y, Zeng Q, Hurley LH. Structural insight into a quinolone-topoisomerase II-DNA complex. Further evidence for a 2:2 quinobenzoxazine-mg2+ self-assembly model formed in the presence of topoisomerase ii. The Journal of Biological Chemistry. 274: 17226-35. PMID 10358081 DOI: 10.1074/Jbc.274.24.17226 |
0.389 |
|
| 1999 |
Han H, Cliff CL, Hurley LH. Accelerated assembly of G-quadruplex structures by a small molecule. Biochemistry. 38: 6981-6. PMID 10353809 DOI: 10.1021/Bi9905922 |
0.459 |
|
| 1999 |
Sun D, Lopez-Guajardo CC, Quada J, Hurley LH, Von Hoff DD. Regulation of catalytic activity and processivity of human telomerase. Biochemistry. 38: 4037-44. PMID 10194316 DOI: 10.1021/Bi982249N |
0.393 |
|
| 1999 |
Han H, Hurley LH, Salazar M. A DNA polymerase stop assay for G-quadruplex-interactive compounds. Nucleic Acids Research. 27: 537-42. PMID 9862977 DOI: 10.1093/Nar/27.2.537 |
0.487 |
|
| 1999 |
Seaman FC, Hurley LH. 31P-Nmr as a probe for drug-nucleic acid interactions Phosphorus, Sulfur and Silicon and Related Elements. 144: 297-300. DOI: 10.1080/10426509908546240 |
0.411 |
|
| 1999 |
Lee SJ, Hurley LH. A thymine:thymine mismatch enhances the pluramycin alkylation site downstream of the TBP-TATA box complex Journal of the American Chemical Society. 121: 8971-8977. DOI: 10.1021/Ja991607M |
0.424 |
|
| 1999 |
Han FX, Wheelhouse RT, Hurley LH. Interactions of TMPyP4 and TMPyP2 with quadruplex DNA. Structural basis for the differential effects on telomerase inhibition Journal of the American Chemical Society. 121: 3561-3570. DOI: 10.1021/Ja984153M |
0.746 |
|
| 1999 |
Lee SJ, Hurley LH. A thymine: Thymine mismatch enhances the pluramycin alkylation site downstream of the TBP - TATA box complex Journal of the American Chemical Society. 121. |
0.312 |
|
| 1998 |
Kwok Y, Hurley LH. Topoisomerase II site-directed alkylation of DNA by psorospermin and its effect on topoisomerase II-mediated DNA cleavage. The Journal of Biological Chemistry. 273: 33020-6. PMID 9830055 DOI: 10.1074/Jbc.273.49.33020 |
0.374 |
|
| 1998 |
Kwok Y, Zeng Q, Hurley LH. Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites. Proceedings of the National Academy of Sciences of the United States of America. 95: 13531-6. PMID 9811834 DOI: 10.1073/Pnas.95.23.13531 |
0.365 |
|
| 1998 |
Zeng Q, Kwok Y, Kerwin SM, Mangold G, Hurley LH. Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model. Journal of Medicinal Chemistry. 41: 4273-8. PMID 9784102 DOI: 10.1021/Jm980265C |
0.323 |
|
| 1998 |
Fedoroff OY, Salazar M, Han H, Chemeris VV, Kerwin SM, Hurley LH. NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA. Biochemistry. 37: 12367-74. PMID 9730808 DOI: 10.1021/Bi981330N |
0.472 |
|
| 1998 |
Fletcher TM, Sun D, Salazar M, Hurley LH. Effect of DNA secondary structure on human telomerase activity. Biochemistry. 37: 5536-41. PMID 9548937 DOI: 10.1021/Bi972681P |
0.385 |
|
| 1998 |
Seaman FC, Hurley LH. Molecular basis for the DNA sequence selectivity of ecteinascidin 736 and 743: Evidence for the dominant role of direct readout via hydrogen bonding Journal of the American Chemical Society. 120: 13028-13041. DOI: 10.1021/Ja983091X |
0.374 |
|
| 1998 |
Moore BM, Seaman FC, Wheelhouse RT, Hurley LH. Mechanism for the catalytic activation of ecteinascidin 743 and its subsequent alkylation of guanine N2 Journal of the American Chemical Society. 120: 2490-2491. DOI: 10.1021/Ja974109R |
0.655 |
|
| 1998 |
Wheelhouse RT, Sun D, Han H, Han FX, Hurley LH. Cationic porphyrins as telomerase inhibitors: The interaction of tetra- (N-methyl-4-pyridyl)porphine with quadruplex DNA [1] Journal of the American Chemical Society. 120: 3261-3262. DOI: 10.1021/Ja973792E |
0.708 |
|
| 1997 |
Sun D, Thompson B, Cathers BE, Salazar M, Kerwin SM, Trent JO, Jenkins TC, Neidle S, Hurley LH. Inhibition of human telomerase by a G-quadruplex-interactive compound. Journal of Medicinal Chemistry. 40: 2113-6. PMID 9216827 DOI: 10.1021/Jm970199Z |
0.347 |
|
| 1997 |
Moore BM, Seaman FC, Hurley LH. NMR-based model of an ecteinascidin 743-DNA adduct [16] Journal of the American Chemical Society. 119: 5475-5476. DOI: 10.1021/Ja9704500 |
0.372 |
|
| 1997 |
Lee SJ, Seaman FC, Sun D, Xiong H, Kelly RC, Hurley LH. Replacement of the Bizelesin ureadiyl linkage by a guanidinium moiety retards translocation from monoalkylation to cross-linking sites on DNA Journal of the American Chemical Society. 119: 3434-3442. DOI: 10.1021/Ja963873V |
0.374 |
|
| 1996 |
Thurston DE, Bose DS, Thompson AS, Howard PW, Leoni A, Croker SJ, Jenkins TC, Neidle S, Hartley JA, Hurley LH. Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents. The Journal of Organic Chemistry. 61: 8141-8147. PMID 11667802 DOI: 10.1021/Jo951631S |
0.394 |
|
| 1996 |
Salazar M, Thompson BD, Kerwin SM, Hurley LH. Thermally induced DNA.RNA hybrid to G-quadruplex transitions: possible implications for telomere synthesis by telomerase. Biochemistry. 35: 16110-5. PMID 8973182 DOI: 10.1021/Bi961442J |
0.412 |
|
| 1996 |
Henderson D, Hurley LH. Specific targeting of protein-DNA complexes by DNA-reactive drugs (+)-CC-1065 and pluramycins. Journal of Molecular Recognition : Jmr. 9: 75-87. PMID 8877797 DOI: 10.1002/(Sici)1099-1352(199603)9:2<75::Aid-Jmr247>3.0.Co;2-4 |
0.458 |
|
| 1996 |
Sun D, Hurley LH, Harshey RM. Structural distortions induced by integration host factor (IHF) at the H' site of phage lambda probed by (+)-CC-1065, pluramycin, and KMnO4 and by DNA cyclization studies. Biochemistry. 35: 10815-27. PMID 8718873 DOI: 10.1021/Bi952786X |
0.429 |
|
| 1996 |
Han FX, Hurley LH. A model for the T-antigen-induced structural alteration of the SV40 replication origin based upon experiments with specific probes for bent, straight, and unwound DNA. Biochemistry. 35: 7993-8001. PMID 8672503 DOI: 10.1021/Bi960251D |
0.384 |
|
| 1996 |
Seaman FC, Chu J, Hurley L. Cross-Linkage by “Intact” Bizelesin and Bisalkylation by the “Separated Halves” of the Bizelesin Dimer: Contrasting Drug Manipulation of DNA Conformation (5‘-TAATTA-3‘) Directs Alkylation toward Different Adenine TargetsJ.Am.Chem.Soc.1996,118, 5383−5395 Journal of the American Chemical Society. 118: 7871-7871. DOI: 10.1021/Ja965415S |
0.347 |
|
| 1996 |
Seaman FC, Hurley LH. Manipulative interplay of the interstrand cross-linker Bizelesin with d(TAATTA)2 to achieve sequence recognition of DNA Journal of the American Chemical Society. 118: 10052-10064. DOI: 10.1021/Ja961924I |
0.406 |
|
| 1996 |
Park HJ, Kelly RC, Hurley LH. The chemical evolution of DNA-DNA interstrand cross-linkers that recognize defined mixed AT and GC sequences Journal of the American Chemical Society. 118: 10041-10051. DOI: 10.1021/Ja961678A |
0.4 |
|
| 1996 |
Hansen M, Lee SJ, Cassady JM, Hurley LH. Molecular details of the structure of a psorospermin - DNA covalent/intercalation complex and associated DNA sequence selectivity Journal of the American Chemical Society. 118: 5553-5561. DOI: 10.1021/Ja960319C |
0.435 |
|
| 1996 |
Yu H, Hurley LH, Kerwin SM. Evidence for the formation of 2:2 drug-Mg2+ dimers in solution and for the formation of dimeric drug complexes on DNA from the DNA-accelerated photochemical reaction of antineoplastic quinobenzoxazines Journal of the American Chemical Society. 118: 7040-7048. DOI: 10.1021/Ja9602859 |
0.386 |
|
| 1996 |
Seaman FC, Chu J, Hurley L. Cross-Linkage by “Intact” Bizelesin and Bisalkylation by the “Separated Halves” of the Bizelesin Dimer: Contrasting Drug Manipulation of DNA Conformation (5‘-TAATTA-3‘) Directs Alkylation toward Different Adenine Targets Journal of the American Chemical Society. 118: 5383-5395. DOI: 10.1021/Ja960017A |
0.337 |
|
| 1995 |
Sun D, Hurley LH. TBP binding to the TATA box induces a specific downstream unwinding site that is targeted by pluramycin. Chemistry & Biology. 2: 457-69. PMID 9383448 DOI: 10.1016/1074-5521(95)90263-5 |
0.433 |
|
| 1995 |
Hansen M, Yun S, Hurley L. Hedamycin intercalates the DNA helix and, through carbohydrate-mediated recognition in the minor groove, directs N7-alkylation of guanine in the major groove in a sequence-specific manner. Chemistry & Biology. 2: 229-40. PMID 9383425 DOI: 10.1016/1074-5521(95)90273-2 |
0.426 |
|
| 1995 |
Fan JY, Sun D, Yu H, Kerwin SM, Hurley LH. Self-assembly of a quinobenzoxazine-Mg2+ complex on DNA: a new paradigm for the structure of a drug-DNA complex and implications for the structure of the quinolone bacterial gyrase-DNA complex. Journal of Medicinal Chemistry. 38: 408-24. PMID 7853333 DOI: 10.1021/Jm00003A003 |
0.405 |
|
| 1995 |
Thompson AS, Fan JY, Sun D, Hansen M, Hurley LH. Determination of the structural role of the internal guanine-cytosine base pair in recognition of a seven-base-pair sequence cross-linked by bizelesin. Biochemistry. 34: 11005-16. PMID 7669758 DOI: 10.1021/Bi00035A006 |
0.373 |
|
| 1995 |
Thompson AS, Hurley LH. Solution conformation of a bizelesin A-tract duplex adduct: DNA-DNA cross-linking of an A-tract straightens out bent DNA. Journal of Molecular Biology. 252: 86-101. PMID 7666436 DOI: 10.1006/Jmbi.1994.0477 |
0.388 |
|
| 1995 |
Henderson D, Hurley LH. Molecular struggle for transcriptional control. Nature Medicine. 1: 525-7. PMID 7585116 DOI: 10.1038/Nm0695-525 |
0.376 |
|
| 1995 |
Mountzouris JA, Wang JJ, Thurston D, Hurley LH. Comparison of a DSB-120 DNA interstrand cross-linked adduct with the corresponding bis-tomaymycin adduct: An example of a successful template- directed approach to drug design based upon the monoalkylating compound tomaymycin (Journal of Medicinal Chemistry (1994) 37 (3138)) Journal of Medicinal Chemistry. 38: 1052. DOI: 10.1021/Jm00006A027 |
0.354 |
|
| 1995 |
Sun D, Hansen M, Hurley L. Molecular Basis for the DNA Sequence Specificity of the Pluramycins. A Novel Mechanism Involving Groove Interactions Transmitted through the Helix via Intercalation To Achieve Sequence Selectivity at the Covalent Bonding Step Journal of the American Chemical Society. 117: 2430-2440. DOI: 10.1021/Ja00114A007 |
0.354 |
|
| 1995 |
Hansen M, Hurley L. Altromycin B Threads the DNA Helix Interacting with Both the Major and the Minor Grooves To Position Itself for Site-Directed Alkylation and Guanine N7 Journal of the American Chemical Society. 117: 2421-2429. DOI: 10.1021/Ja00114A006 |
0.357 |
|
| 1995 |
Thompson AS, Sun D, Hurley LH. Monoalkylation and cross-linking of DNA by cyclopropapyrroloindoles entraps bent and straight forms of A-tracts Journal of the American Chemical Society. 117: 2371-2372. DOI: 10.1021/Ja00113A035 |
0.354 |
|
| 1994 |
Sun D, Hurley LH. Cooperative bending of the 21-base-pair repeats of the SV40 viral early promoter by human Sp1. Biochemistry. 33: 9578-87. PMID 8068633 DOI: 10.1021/Bi00198A025 |
0.437 |
|
| 1994 |
Sun D, Hurley LH. Binding of Sp1 to the 21-bp repeat region of SV40 DNA: effect of intrinsic and drug-induced DNA bending between GC boxes. Gene. 149: 165-72. PMID 7958981 DOI: 10.1016/0378-1119(94)90425-1 |
0.42 |
|
| 1994 |
Mountzouris JA, Wang JJ, Thurston D, Hurley LH. Comparison of a DSB-120 DNA interstrand cross-linked adduct with the corresponding bis-tomaymycin adduct: an example of a successful template-directed approach to drug design based upon the monoalkylating compound tomaymycin. Journal of Medicinal Chemistry. 37: 3132-40. PMID 7932537 DOI: 10.1021/Jm00045A019 |
0.408 |
|
| 1994 |
Hurley LH, Sun D. (+)-CC-1065 as a probe for intrinsic and protein-induced bending of DNA. Journal of Molecular Recognition : Jmr. 7: 123-32. PMID 7826672 DOI: 10.1002/Jmr.300070209 |
0.437 |
|
| 1994 |
Jenkins TC, Hurley LH, Neidle S, Thurston DE. Structure of a covalent DNA minor groove adduct with a pyrrolobenzodiazepine dimer: evidence for sequence-specific interstrand cross-linking. Journal of Medicinal Chemistry. 37: 4529-37. PMID 7799403 DOI: 10.1021/Jm00052A012 |
0.416 |
|
| 1994 |
Ding ZM, Harshey RM, Hurley LH. (+)-CC-1065 as a structural probe of mu transposase-induced bending of DNA: Overcoming limitations of hydroxyl-radical footprinting Nucleic Acids Research. 22: 256. DOI: 10.1093/Nar/22.2.256 |
0.337 |
|
| 1993 |
Ding ZM, Harshey RM, Hurley LH. (+)-CC-1065 as a structural probe of Mu transposase-induced bending of DNA: overcoming limitations of hydroxyl-radical footprinting. Nucleic Acids Research. 21: 4281-7. PMID 8414983 DOI: 10.1093/nar/21.18.4281 |
0.304 |
|
| 1993 |
Sun D, Lin CH, Hurley LH. A-tract and (+)-CC-1065-induced bending of DNA. Comparison of structural features using non-denaturing gel analysis, hydroxyl-radical footprinting, and high-field NMR. Biochemistry. 32: 4487-95. PMID 8387334 DOI: 10.1021/Bi00068A003 |
0.379 |
|
| 1993 |
Kizu R, Draves PH, Hurley LH. Correlation of DNA sequence specificity of anthramycin and tomaymycin with reaction kinetics and bending of DNA. Biochemistry. 32: 8712-22. PMID 8357813 DOI: 10.1021/Bi00084A043 |
0.393 |
|
| 1993 |
Sun D, Hansen M, Clement JJ, Hurley LH. Structure of the altromycin B (N7-guanine)-DNA adduct. A proposed prototypic DNA adduct structure for the pluramycin antitumor antibiotics. Biochemistry. 32: 8068-74. PMID 8347608 DOI: 10.1021/Bi00083A003 |
0.414 |
|
| 1993 |
Aristoff PA, Johnson PD, Sun D, Hurley LH. Synthesis and biochemical evaluation of the CBI-PDE-I-dimer, a benzannelated analog of (+)-CC-1065 that also produces delayed toxicity in mice. Journal of Medicinal Chemistry. 36: 1956-63. PMID 8336335 DOI: 10.1021/Jm00066A004 |
0.363 |
|
| 1993 |
Seaman FC, Hurley L. Interstrand cross-linking by bizelesin produces a Watson-Crick to Hoogsteen base-pairing transition region in d(CGTAATTACG)2. Biochemistry. 32: 12577-85. PMID 8251475 DOI: 10.1021/Bi00210A005 |
0.407 |
|
| 1993 |
Sun D, Park HJ, Hurley LH. Alkylation of guanine and cytosine in DNA by bizelesin. Evidence for a covalent immobilization leading to a proximity-driven alkylation of normally unreactive bases by a (+)-CC-1065 cross-linking compound. Chemical Research in Toxicology. 6: 889-94. PMID 8117929 DOI: 10.1021/Tx00036A020 |
0.395 |
|
| 1993 |
Sun D, Hurley LH. Analysis of the monoalkylation and cross-linking sequence specificity of bizelesin, a bifunctional alkylation agent related to (+)-CC-1065 Journal of the American Chemical Society. 115: 5925-5933. DOI: 10.1021/Ja00067A005 |
0.371 |
|
| 1992 |
Sun D, Hurley LH. Structure-activity relationships of (+)-CC-1065 analogues in the inhibition of helicase-catalyzed unwinding of duplex DNA. Journal of Medicinal Chemistry. 35: 1773-82. PMID 1588557 DOI: 10.1021/Jm00088A012 |
0.435 |
|
| 1992 |
Sun D, Hurley LH. Effect of the (+)-CC-1065-(N3-adenine)DNA adduct on in vitro DNA synthesis mediated by Escherichia coli DNA polymerase. Biochemistry. 31: 2822-9. PMID 1547223 DOI: 10.1021/Bi00125A025 |
0.435 |
|
| 1992 |
Sun D, Hurley LH. Inhibition of T4 DNA ligase activity by (+)-CC-1065: demonstration of the importance of the stiffening and winding effects of (+)-CC-1065 on DNA. Anti-Cancer Drug Design. 7: 15-36. PMID 1543525 |
0.311 |
|
| 1992 |
Wang JJ, Hill GC, Hurley LH. Template-directed design of a DNA-DNA cross-linker based upon a bis-tomaymycin-duplex adduct. Journal of Medicinal Chemistry. 35: 2995-3002. PMID 1501225 DOI: 10.1021/Jm00094A010 |
0.396 |
|
| 1992 |
Lin CH, Hill GC, Hurley LH. Characterization of a 12-mer duplex d(GGCGGAGTTAGG).d(CCTAACTCCGCC) containing a highly reactive (+)-CC-1065 sequence by 1H and 31P NMR, hydroxyl-radical footprinting, and NOESY restrained molecular dynamics calculations. Chemical Research in Toxicology. 5: 167-82. PMID 1322736 DOI: 10.1021/Tx00026A005 |
0.412 |
|
| 1992 |
Maine IP, Sun D, Hurley LH, Kodadek T. The antitumor agent CC-1065 inhibits helicase-catalyzed unwinding of duplex DNA. Biochemistry. 31: 3968-75. PMID 1314652 DOI: 10.1021/Bi00131A012 |
0.372 |
|
| 1992 |
Bose DS, Thompson AS, Ching J, Hartley JA, Berardini MD, Jenkins TC, Neidle S, Hurley LH, Thurston DE. Rational design of a highly efficient irreversible DNA interstrand cross-linking agent based on the pyrrolobenzodiazepine ring system Journal of the American Chemical Society. 114: 4939-4941. DOI: 10.1021/Ja00038A089 |
0.336 |
|
| 1992 |
Maine IP, Sun D, Hurley LH, Kodadek T. The antitumor agent CC-1065 inhibits helicase-catalyzed unwinding of duplex DNA. [Erratum to document cited in CA116(23):227766s] Biochemistry. 31: 10642-10642. DOI: 10.1021/Bi00158A029 |
0.339 |
|
| 1991 |
Lin CH, Beale JM, Hurley LH. Structure of the (+)-CC-1065-DNA adduct: critical role of ordered water molecules and implications for involvement of phosphate catalysis in the covalent reaction. Biochemistry. 30: 3597-602. PMID 2015216 DOI: 10.1021/Bi00229A002 |
0.382 |
|
| 1991 |
Tang MS, Nazimiec ME, Doisy RP, Pierce JR, Hurley LH, Alderete BE. Repair of helix-stabilizing anthramycin-N2 guanine DNA adducts by UVRA and UVRB proteins. Journal of Molecular Biology. 220: 855-66. PMID 1831859 DOI: 10.1016/0022-2836(91)90358-D |
0.4 |
|
| 1991 |
Lee CS, Sun D, Kizu R, Hurley LH. Determination of the structural features of (+)-CC-1065 that are responsible for bending and winding of DNA. Chemical Research in Toxicology. 4: 203-13. PMID 1782349 DOI: 10.1021/Tx00020A013 |
0.446 |
|
| 1991 |
Ding ZM, Hurley LH. DNA interstrand cross-linking, DNA sequence specificity, and induced conformational changes produced by a dimeric analog of (+)-CC-1065. Anti-Cancer Drug Design. 6: 427-52. PMID 1662513 |
0.3 |
|
| 1991 |
Lin CH, Sun DY, Hurley LH. (+)-CC-1065 produces bending of DNA that appears to resemble adenine/thymine tracts. Chemical Research in Toxicology. 4: 21-6. PMID 1655087 DOI: 10.1021/Tx00019A003 |
0.397 |
|
| 1990 |
Boyd FL, Stewart D, Remers WA, Barkley MD, Hurley LH. Characterization of a unique tomaymycin-d(CICGAATTCICG)2 adduct containing two drug molecules per duplex by NMR, fluorescence, and molecular modeling studies. Biochemistry. 29: 2387-403. PMID 2337606 DOI: 10.1021/Bi00461A024 |
0.373 |
|
| 1990 |
Lin CH, Hurley LH. Determination of the major tautomeric form of the covalently modified adenine in the (+)-CC-1065-DNA adduct by 1H and 15N NMR studies. Biochemistry. 29: 9503-7. PMID 2271598 DOI: 10.1021/Bi00493A002 |
0.331 |
|
| 1990 |
Hurley LH, Warpehoski MA, Lee CS, McGovren JP, Scahill TA, Kelly RC, Mitchell MA, Wicnienski NA, Gebhard I. Sequence specificity of DNA alkylation by the unnatural enantiomer of CC-1065 and its synthetic analogs Journal of the American Chemical Society. 112: 4633-4649. DOI: 10.1021/Ja00168A003 |
0.388 |
|
| 1990 |
Boyd FL, Cheatham SF, Remers W, Hill GC, Hurley LH. Characterization of the structure of the anthramycin-d(ATGCAT)2 adduct by NMR and molecular modeling studies. Determination of the stereochemistry of the covalent linkage site, orientation in the minor groove of DNA, and effect on local DNA structure Journal of the American Chemical Society. 112: 3279-3289. DOI: 10.1021/Ja00165A004 |
0.37 |
|
| 1989 |
Hurley LH. DNA and associated targets for drug design. Journal of Medicinal Chemistry. 32: 2027-33. PMID 2671370 DOI: 10.1021/Jm00129A001 |
0.339 |
|
| 1988 |
Hurley LH, Lee CS, McGovren JP, Warpehoski MA, Mitchell MA, Kelly RC, Aristoff PA. Molecular basis for sequence-specific DNA alkylation by CC-1065. Biochemistry. 27: 3886-92. PMID 3408734 DOI: 10.1021/Bi00410A054 |
0.454 |
|
| 1988 |
Hurley LH, Lee CS, McGovren JP, Warpehoski MA, Mitchell MA, Kelly RC, Aristoff PA. Reaction of CC-1065 and select synthetic analogs with DNA. Biochemical Pharmacology. 37: 1795-6. PMID 3377837 DOI: 10.1016/0006-2952(88)90450-9 |
0.342 |
|
| 1988 |
Hurley LH, Boyd FL. DNA as a target for drug action. Trends in Pharmacological Sciences. 9: 402-7. PMID 3078076 DOI: 10.1016/0165-6147(88)90067-3 |
0.375 |
|
| 1988 |
Warpehoski MA, Hurley LH. Sequence selectivity of DNA covalent modification. Chemical Research in Toxicology. 1: 315-33. PMID 2979748 DOI: 10.1021/Tx00006A001 |
0.358 |
|
| 1988 |
Hurley LH, Reck T, Thurston DE, Langley DR, Holden KG, Hertzberg RP, Hoover JR, Gallagher G, Faucette LF, Mong SM. Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds. Chemical Research in Toxicology. 1: 258-68. PMID 2979741 DOI: 10.1021/Tx00005A002 |
0.418 |
|
| 1988 |
Tang MS, Lee CS, Doisy R, Ross L, Needham-VanDevanter DR, Hurley LH. Recognition and repair of the CC-1065-(N3-adenine)-DNA adduct by the UVRABC nucleases. Biochemistry. 27: 893-901. PMID 2966637 DOI: 10.1021/Bi00403A009 |
0.407 |
|
| 1987 |
Hurley LH, Needham-VanDevanter DR, Chong-Soon Lee. Demonstration of the asymmetric effect of CC-1065 on local DNA structure using a site-directed adduct in a 117-base-pair fragment from M13mp1 Proceedings of the National Academy of Sciences of the United States of America. 84: 6412-6416. PMID 2819875 DOI: 10.1073/Pnas.84.18.6412 |
0.443 |
|
| 1987 |
Hurley LH, Boyd FL. Chapter 26 Approaches Toward the Design of Sequence-Specific Drugs for DNA Annual Reports in Medicinal Chemistry. 22: 259-268. DOI: 10.1016/S0065-7743(08)61174-4 |
0.334 |
|
| 1986 |
Jacobson MK, Twehous D, Hurley LH. Depletion of nicotinamide adenine dinucleotide in normal and xeroderma pigmentosum fibroblast cells by the antitumor drug CC-1065 Biochemistry. 25: 5929-5932. PMID 3790494 DOI: 10.1021/Bi00368A014 |
0.395 |
|
| 1986 |
Hurley LH, Needham-VanDevanter DR. Sequence specificity and biological consequences of drugs that bind covalently in the minor groove of DNA Basic Life Sciences. 38: 203-210. PMID 3741332 DOI: 10.1007/978-1-4615-9462-8_21 |
0.415 |
|
| 1986 |
Barkley MD, Cheatham S, Thurston DE, Hurley LH. Pyrrolo[1,4]benzodiazepine antitumor antibiotics: Evidence for two forms of tomaymycin bound to DNA Biochemistry. 25: 3021-3031. PMID 3718937 DOI: 10.1021/Bi00358A043 |
0.336 |
|
| 1986 |
Needham-VanDevanter DR, Hurley LH. Construction and characterization of a site-directed CC-1065-N3-adenine adduct within a 117 base pair DNA restriction fragment Biochemistry. 25: 8430-8436. PMID 3030397 DOI: 10.1021/Bi00374A016 |
0.448 |
|
| 1986 |
Hertzberg RP, Hecht SM, Reynolds VL, Molineux IJ, Hurley LH. DNA sequence specificity of the pyrrolo[1,4]benzodiazepine antitumor antibiotics. Methidiumpropyl-EDTA-iron(II) footprinting analysis of DNA binding sites for anthramycin and related drugs Biochemistry. 25: 1249-1258. PMID 3008824 DOI: 10.1021/Bi00354A009 |
0.408 |
|
| 1986 |
Hurley LH, Needham-VanDevanter DR. Covalent binding of antitumor antibiotics in the minor groove of DNA. Mechanism of action of CC-1065 and the pyrrolo (1,4) benzodiazepines Accounts of Chemical Research®. 19: 230-237. DOI: 10.1021/Ar00128A001 |
0.385 |
|
| 1985 |
Reynolds VL, Molineux IJ, Kaplan DJ, Swenson DH, Hurley LH. Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity Biochemistry. 24: 6228-6237. PMID 3002434 DOI: 10.1021/Bi00343A029 |
0.431 |
|
| 1984 |
Hurley LH, Reynolds VL, Swenson DH, Petzold GL, Scahill TA. Reaction of the antitumor antibiotic CC-1065 with DNA: Structure of a DNA adduct with DNA sequence specificity Science. 226: 843-844. PMID 6494915 DOI: 10.1126/Science.6494915 |
0.407 |
|
| 1984 |
Needham-VanDevanter DR, Hurley LH, Reynolds VL, Theriault NY, Krueger WC, Wierenga W. Characterization of an adduct between CC-1065 and a defined oligodeoxynucleotide duplex. Nucleic Acids Research. 12: 6159-68. PMID 6473105 DOI: 10.1093/Nar/12.15.6159 |
0.415 |
|
| 1984 |
Hurley LH, Thurston DE. Pyrrolo(l ,4)benzodiazepine Antitumor Antibiotics: Chemistry, Interaction with DNA, and Biological Implications Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 1: 52-59. DOI: 10.1023/A:1016395113085 |
0.417 |
|
| 1982 |
Reynolds VL, Hurley LH. Comparison of properties of the in vitro and cellular anthramycin-DNA adducts and characterization of the reaction of anthramycin with chromatin Chemico-Biological Interactions. 42: 141-151. PMID 7151226 DOI: 10.1016/0009-2797(82)90128-4 |
0.404 |
|
| 1981 |
Kaplan DJ, Hurley LH. Anthramycin binding to deoxyribonucleic acid-mitomycin C complexes. Evidence for drug-induced deoxyribonucleic acid conformational change and cooperativity in mitomycin C binding Biochemistry. 20: 7572-7580. PMID 6798992 DOI: 10.1021/Bi00529A036 |
0.406 |
|
| 1981 |
Petrusek RL, Anderson GL, Garner TF, Fannin QL, Kaplan DJ, Zimmer SG, Hurley LH. Pyrrolo[1,4]benzodiazepine antibiotics. Proposed structures and characteristics of the in vitro deoxyribonucleic acid adducts of anthramycin, tomaymycin, sibiromycin, and neothramycins A and B Biochemistry. 20: 1111-1119. PMID 6261786 DOI: 10.1021/Bi00508A011 |
0.426 |
|
| 1980 |
Otsuka H, Mascaretti OA, Hurley LH, Floss HG. Stereochemical aspects of the biosynthesis of spectinomycin Journal of the American Chemical Society. 102: 6817-6820. DOI: 10.1002/Chin.198104343 |
0.48 |
|
| 1979 |
Hurley LH, Lasswell WL, Ostrander JM, Parry R. Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthetic conversion of tyrosine to the C2- and C3-proline moieties of anthramycin, tomaymycin, and sibiromycin. Biochemistry. 18: 4230-7. PMID 582801 DOI: 10.1021/Bi00586A030 |
0.302 |
|
| 1979 |
Hurley LH, Petrusek R. Proposed structure of the anthramycin-DNA adduct [25] Nature. 282: 529-531. PMID 503235 DOI: 10.1038/282529A0 |
0.416 |
|
| 1978 |
Hannan MA, Hurley LH. Pathways to DNA repair operating in yeast treated with the pyrrolo(1,4)-benzodiazepine antitumor antibiotics Journal of Antibiotics. 31: 911-913. PMID 361666 DOI: 10.7164/Antibiotics.31.911 |
0.328 |
|
| 1977 |
Hurley LH. Pyrrolo(1,4)benzodiazepine antitumor antibiotics. Comparative aspects of anthramycin, tomaymycin and sibiromycin Journal of Antibiotics. 30: 349-370. PMID 328469 DOI: 10.7164/Antibiotics.30.349 |
0.415 |
|
| 1977 |
Hurley LH, Gairola C, Zmijewski M. Pyrrolo(1,4)benzodiazepine antitumor antibiotics In vitro interaction of anthramycin, sibiromycin and tomaymycin with DNA using specifically radiolabelled molecules Bba Section Nucleic Acids and Protein Synthesis. 475: 521-535. PMID 15599 DOI: 10.1016/0005-2787(77)90067-3 |
0.412 |
|
| 1976 |
Chang CJ, Floss HG, Hurley LH, Zmijewski M. Application of long-range spin-spin couplings in biosynthetic studies. The Journal of Organic Chemistry. 41: 2932-4. PMID 956946 DOI: 10.1021/Jo00879A033 |
0.421 |
|
| 1971 |
Hornemann U, Hurley LH, Speedie MK, Floss HG. The biosynthesis of indolmycin Journal of the American Chemical Society. 93: 3028-3035. PMID 5095271 DOI: 10.1021/Ja00741A035 |
0.473 |
|
| 1970 |
Hornemann U, Speedie MK, Hurley LH, Floss HG. Demonstration of a C-methylating enzyme in cell free extracts of indolmycin-producing Streptomycesgriseus Biochemical and Biophysical Research Communications. 39: 594-599. PMID 5490210 DOI: 10.1016/0006-291X(70)90245-7 |
0.484 |
|
| 1970 |
Hornemann U, Hurley LH, Speedie MK, Floss HG. Isolation and absolute configuration of indolmycenic acid, an intermediate in the biosynthesis of indolmycin by streptomyces griseus Tetrahedron Letters. 11: 2255-2258. PMID 5447649 DOI: 10.1016/S0040-4039(01)98202-4 |
0.436 |
|
| 1969 |
Hornemann U, Speedie MK, Kelley KM, Hurley LH, Floss HG. Biosynthesis of indoleisopropionic acid by Claviceps. Biological C-methylation involving an intact methyl group. Archives of Biochemistry and Biophysics. 131: 430-40. PMID 5787216 DOI: 10.1016/0003-9861(69)90415-9 |
0.465 |
|
| 1969 |
Hornemann U, Hurley LH, Speedie MK, Guenther HF, Floss HG. Biosynthesis of the antibiotic indolmycin by Streptomyces griseus. C-Methylation at the β-carbon atom of the tryptophan side-chain Journal of the Chemical Society D: Chemical Communications. 245-246. DOI: 10.1039/C29690000245 |
0.47 |
|
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