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Jarek Wegiel, Ph.D. - Publications

Affiliations: 
2013 Biology City University of New York, New York, NY, United States 
Area:
Neuroscience Biology, Clinical Psychology, Developmental Psychology
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wegiel J, Chadman K, London E, Wisniewski T, Wegiel J. Contribution of the serotonergic system to developmental brain abnormalities in autism spectrum disorder. Autism Research : Official Journal of the International Society For Autism Research. PMID 38500252 DOI: 10.1002/aur.3123  0.342
2022 Wegiel J, Flory M, Kuchna I, Nowicki K, Wegiel J, Ma SY, Zhong N, Bobrowicz TW, de Leon M, Lai F, Silverman WP, Wisniewski T. Developmental deficits and staging of dynamics of age associated Alzheimer's disease neurodegeneration and neuronal loss in subjects with Down syndrome. Acta Neuropathologica Communications. 10: 2. PMID 34983655 DOI: 10.1186/s40478-021-01300-9  0.338
2018 Wegiel J, Brown WT, La Fauci G, Adayev T, Kascsak R, Kascsak R, Flory M, Kaczmarski W, Kuchna I, Nowicki K, Martinez-Cerdeno V, Wisniewski T, Wegiel J. The role of reduced expression of fragile X mental retardation protein in neurons and increased expression in astrocytes in idiopathic and syndromic autism (duplications 15q11.2-q13). Autism Research : Official Journal of the International Society For Autism Research. PMID 30107092 DOI: 10.1002/Aur.2003  0.702
2017 Wegiel J, Flory M, Kuchna I, Nowicki K, Yong Ma S, Wegiel J, Badmaev E, Silverman WP, de Leon M, Reisberg B, Wisniewski T. Multiregional Age-Associated Reduction of Brain Neuronal Reserve Without Association With Neurofibrillary Degeneration or β-Amyloidosis. Journal of Neuropathology and Experimental Neurology. 76: 439-457. PMID 28505333 DOI: 10.1093/Jnen/Nlx027  0.434
2015 Wegiel J, Flory M, Schanen NC, Cook EH, Nowicki K, Kuchna I, Imaki H, Ma SY, Wegiel J, London E, Casanova MF, Wisniewski T, Brown WT. Significant neuronal soma volume deficit in the limbic system in subjects with 15q11.2-q13 duplications. Acta Neuropathologica Communications. 3: 63. PMID 26463344 DOI: 10.1186/S40478-015-0241-Z  0.444
2015 Wegiel J, Flory M, Kuchna I, Nowicki K, Ma SY, Imaki H, Wegiel J, Frackowiak J, Kolecka BM, Wierzba-Bobrowicz T, London E, Wisniewski T, Hof PR, Brown WT. Neuronal nucleus and cytoplasm volume deficit in children with autism and volume increase in adolescents and adults. Acta Neuropathologica Communications. 3: 2. PMID 25595448 DOI: 10.1186/S40478-015-0183-5  0.435
2014 Wegiel J, Flory M, Kuchna I, Nowicki K, Ma SY, Imaki H, Wegiel J, Cohen IL, London E, Wisniewski T, Brown WT. Stereological study of the neuronal number and volume of 38 brain subdivisions of subjects diagnosed with autism reveals significant alterations restricted to the striatum, amygdala and cerebellum. Acta Neuropathologica Communications. 2: 141. PMID 25231243 DOI: 10.1186/S40478-014-0141-7  0.442
2014 Wegiel J, Flory M, Kuchna I, Nowicki K, Ma SY, Imaki H, Wegiel J, Cohen IL, London E, Brown WT, Wisniewski T. Brain-region-specific alterations of the trajectories of neuronal volume growth throughout the lifespan in autism. Acta Neuropathologica Communications. 2: 28. PMID 24612906 DOI: 10.1186/2051-5960-2-28  0.451
2014 Kaczmarski W, Barua M, Mazur-Kolecka B, Frackowiak J, Dowjat W, Mehta P, Bolton D, Hwang YW, Rabe A, Albertini G, Wegiel J. Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Journal of Neuroscience Research. 92: 162-73. PMID 24327345 DOI: 10.1002/Jnr.23279  0.365
2013 Wegiel J, Kuchna I, Nowicki K, Imaki H, Wegiel J, Ma SY, Azmitia EC, Banerjee P, Flory M, Cohen IL, London E, Brown WT, Komich Hare C, Wisniewski T. Contribution of olivofloccular circuitry developmental defects to atypical gaze in autism. Brain Research. 1512: 106-22. PMID 23558308 DOI: 10.1016/J.Brainres.2013.03.037  0.541
2012 Dowjat K, Adayev T, Kaczmarski W, Wegiel J, Hwang YW. Gene dosage-dependent association of DYRK1A with the cytoskeleton in the brain and lymphocytes of down syndrome patients. Journal of Neuropathology and Experimental Neurology. 71: 1100-12. PMID 23147510 DOI: 10.1097/NEN.0b013e31827733c8  0.701
2012 Xie W, Adayev T, Zhu H, Wegiel J, Wieraszko A, Hwang YW. Activity-dependent phosphorylation of dynamin 1 at serine 857. Biochemistry. 51: 6786-96. PMID 22857010 DOI: 10.1021/Bi2017798  0.697
2012 Wegiel J, Frackowiak J, Mazur-Kolecka B, Schanen NC, Cook EH, Sigman M, Brown WT, Kuchna I, Wegiel J, Nowicki K, Imaki H, Ma SY, Chauhan A, Chauhan V, Miller DL, et al. Abnormal intracellular accumulation and extracellular Aβ deposition in idiopathic and Dup15q11.2-q13 autism spectrum disorders. Plos One. 7: e35414. PMID 22567102 DOI: 10.1371/Journal.Pone.0035414  0.375
2012 Wegiel J, Schanen NC, Cook EH, Sigman M, Brown WT, Kuchna I, Nowicki K, Wegiel J, Imaki H, Ma SY, Marchi E, Wierzba-Bobrowicz T, Chauhan A, Chauhan V, Cohen IL, et al. Differences between the pattern of developmental abnormalities in autism associated with duplications 15q11.2-q13 and idiopathic autism. Journal of Neuropathology and Experimental Neurology. 71: 382-97. PMID 22487857 DOI: 10.1097/Nen.0B013E318251F537  0.336
2012 Mazur-Kolecka B, Golabek A, Kida E, Rabe A, Hwang YW, Adayev T, Wegiel J, Flory M, Kaczmarski W, Marchi E, Frackowiak J. Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice. Journal of Neuroscience Research. 90: 999-1010. PMID 22252917 DOI: 10.1002/jnr.23007  0.695
2011 Adayev T, Wegiel J, Hwang YW. Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A). Archives of Biochemistry and Biophysics. 507: 212-8. PMID 21185805 DOI: 10.1016/j.abb.2010.12.024  0.657
2011 Wegiel J, Kaczmarski W, Barua M, Kuchna I, Nowicki K, Wang KC, Wegiel J, Yang SM, Frackowiak J, Mazur-Kolecka B, Silverman WP, Reisberg B, Monteiro I, de Leon M, Wisniewski T, et al. Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome. Journal of Neuropathology and Experimental Neurology. 70: 36-50. PMID 21157379 DOI: 10.1097/Nen.0B013E318202Bfa1  0.712
2011 Wegiel J, Gong CX, Hwang YW. The role of DYRK1A in neurodegenerative diseases. The Febs Journal. 278: 236-45. PMID 21156028 DOI: 10.1111/j.1742-4658.2010.07955.x  0.446
2010 Wegiel J, Kuchna I, Nowicki K, Imaki H, Wegiel J, Marchi E, Ma SY, Chauhan A, Chauhan V, Bobrowicz TW, de Leon M, Louis LA, Cohen IL, London E, Brown WT, et al. The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes. Acta Neuropathologica. 119: 755-70. PMID 20198484 DOI: 10.1007/S00401-010-0655-4  0.453
2008 Wegiel J, Dowjat K, Kaczmarski W, Kuchna I, Nowicki K, Frackowiak J, Mazur Kolecka B, Wegiel J, Silverman WP, Reisberg B, Deleon M, Wisniewski T, Gong CX, Liu F, Adayev T, et al. The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome. Acta Neuropathologica. 116: 391-407. PMID 18696092 DOI: 10.1007/S00401-008-0419-6  0.728
2008 Shi J, Zhang T, Zhou C, Chohan MO, Gu X, Wegiel J, Zhou J, Hwang YW, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome. The Journal of Biological Chemistry. 283: 28660-9. PMID 18658135 DOI: 10.1074/Jbc.M802645200  0.343
2008 Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA. Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6926-37. PMID 18596167 DOI: 10.1523/Jneurosci.0800-08.2008  0.351
2008 Liu F, Liang Z, Wegiel J, Hwang YW, Iqbal K, Grundke-Iqbal I, Ramakrishna N, Gong CX. Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3224-33. PMID 18509201 DOI: 10.1096/Fj.07-104539  0.404
2008 Liang Z, Liu F, Iqbal K, Grundke-Iqbal I, Wegiel J, Gong CX. Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome. Journal of Alzheimer's Disease : Jad. 13: 295-302. PMID 18430997 DOI: 10.3233/Jad-2008-13307  0.374
2007 Wegiel J, Kuchna I, Nowicki K, Frackowiak J, Mazur-Kolecka B, Imaki H, Wegiel J, Mehta PD, Silverman WP, Reisberg B, Deleon M, Wisniewski T, Pirttilla T, Frey H, Lehtimäki T, et al. Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration. Acta Neuropathologica. 113: 389-402. PMID 17237937 DOI: 10.1007/S00401-006-0191-4  0.388
2007 Dowjat WK, Adayev T, Kuchna I, Nowicki K, Palminiello S, Hwang YW, Wegiel J. Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome. Neuroscience Letters. 413: 77-81. PMID 17145134 DOI: 10.1016/j.neulet.2006.11.026  0.709
2006 Adayev T, Chen-Hwang MC, Murakami N, Wegiel J, Hwang YW. Kinetic properties of a MNB/DYRK1A mutant suitable for the elucidation of biochemical pathways. Biochemistry. 45: 12011-9. PMID 17002300 DOI: 10.1021/bi060632j  0.652
2005 Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, Cuervo AM. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. Journal of Neuropathology and Experimental Neurology. 64: 113-22. PMID 15751225 DOI: 10.1093/Jnen/64.2.113  0.305
2004 Wegiel J, Imaki H, Wang KC, Wegiel J, Rubenstein R. Cells of monocyte/microglial lineage are involved in both microvessel amyloidosis and fibrillar plaque formation in APPsw tg mice. Brain Research. 1022: 19-29. PMID 15353209 DOI: 10.1016/J.Brainres.2004.06.058  0.319
2004 Nagele RG, Wegiel J, Venkataraman V, Imaki H, Wang KC, Wegiel J. Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease. Neurobiology of Aging. 25: 663-74. PMID 15172746 DOI: 10.1016/J.Neurobiolaging.2004.01.007  0.368
2004 Wegiel J, Kuchna I, Nowicki K, Frackowiak J, Dowjat K, Silverman WP, Reisberg B, DeLeon M, Wisniewski T, Adayev T, Chen-Hwang MC, Hwang YW. Cell type- and brain structure-specific patterns of distribution of minibrain kinase in human brain. Brain Research. 1010: 69-80. PMID 15126119 DOI: 10.1016/J.Brainres.2004.03.008  0.718
2004 Gong CX, Liu F, Wu G, Rossie S, Wegiel J, Li L, Grundke-Iqbal I, Iqbal K. Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5. Journal of Neurochemistry. 88: 298-310. PMID 14690518 DOI: 10.1111/J.1471-4159.2004.02147.X  0.392
2003 Wegiel J, Imaki H, Wang KC, Wegiel J, Wronska A, Osuchowski M, Rubenstein R. Origin and turnover of microglial cells in fibrillar plaques of APPsw transgenic mice. Acta Neuropathologica. 105: 393-402. PMID 12624793 DOI: 10.1007/S00401-002-0660-3  0.36
2001 Gong CX, Lidsky T, Wegiel J, Grundke-Iqbal I, Iqbal K. Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain. Brain Research. Brain Research Protocols. 6: 134-40. PMID 11223412 DOI: 10.1016/S1385-299X(00)00046-5  0.396
2000 Gong CX, Lidsky T, Wegiel J, Zuck L, Grundke-Iqbal I, Iqbal K. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease. The Journal of Biological Chemistry. 275: 5535-44. PMID 10681533 DOI: 10.1074/Jbc.275.8.5535  0.372
2000 Gong CX, Wegiel J, Lidsky T, Zuck L, Avila J, Wisniewski HM, Grundke-Iqbal I, Iqbal K. Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain. Brain Research. 853: 299-309. PMID 10640627 DOI: 10.1016/S0006-8993(99)02294-5  0.336
2000 Bennecib M, Gong CX, Wegiel J, Lee MH, Grundke-lqbal I, Lqbal K. Inhibition of protein phosphatases and regulation of tau phosphorylation in rat brain Alzheimer's Reports. 3: 295-304.  0.323
1999 Sadowski M, Wisniewski HM, Tarnawski M, Kozlowski PB, Lach B, Wegiel J. Entorhinal cortex of aged subjects with Down's syndrome shows severe neuronal loss caused by neurofibrillary pathology. Acta Neuropathologica. 97: 156-64. PMID 9928826 DOI: 10.1007/S004010050968  0.316
1998 Wegiel J, Wisniewski HM, SoÅ‚tysiak Z. Region- and cell-type-specific pattern of tau phosphorylation in dog brain. Brain Research. 802: 259-66. PMID 9748620 DOI: 10.1016/S0006-8993(98)00542-3  0.38
1997 Kim KS, Wegiel J, Sapienza V, Chen J, Hong H, Wisniewski HM. Immunoreactivity of presenilin-1 in human, rat and mouse brain. Brain Research. 757: 159-63. PMID 9200512 DOI: 10.1016/S0006-8993(97)00243-6  0.304
1996 Morys J, Bobinski M, Wegiel J, Wisniewski HM, Narkiewicz O. Alzheimer's disease severely affects areas of the claustrum connected with the entorhinal cortex. Journal Fã¼R Hirnforschung. 37: 173-80. PMID 8776503  0.33
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