Samuel H. Speck - Publications

Affiliations: 
Washington University, Saint Louis, St. Louis, MO 
Area:
Microbiology Biology, Immunology

148 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Schwerk J, Kemper L, Bussey KA, Lienenklaus S, Weiss S, Čičin-Šain L, Kröger A, Kalinke U, Collins CM, Speck SH, Messerle M, Wirth D, Brinkmann MM, Hauser H, Köster M. Type I Interferon Signaling Controls Gammaherpesvirus Latency In Vivo. Pathogens (Basel, Switzerland). 11. PMID 36558888 DOI: 10.3390/pathogens11121554  0.379
2020 Liu S, Lei Z, Li J, Wang L, Jia R, Liu Z, Jiang C, Gao Y, Liu M, Kuang L, Qian Z, Zhou D, Speck SH, Liang X. Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation. Plos Pathogens. 16: e1008701. PMID 32735617 DOI: 10.1371/Journal.Ppat.1008701  0.467
2020 Collins CM, Scharer CD, Murphy TJ, Boss JM, Speck SH. Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment. Plos Pathogens. 16: e1008438. PMID 32353066 DOI: 10.1371/Journal.Ppat.1008438  0.53
2018 Feng Y, Livingston-Rosanoff D, Roback L, Sundararajan A, Speck SH, Mocarski ES, Daley-Bauer LP. Remarkably Robust Antiviral Immune Response despite Combined Deficiency in Caspase-8 and RIPK3. Journal of Immunology (Baltimore, Md. : 1950). PMID 30194111 DOI: 10.4049/Jimmunol.1800110  0.473
2017 Terrell S, Speck SH. Murine gammaherpesvirus M2 antigen modulates splenic B cell activation and terminal differentiation in vivo. Plos Pathogens. 13: e1006543. PMID 28767707 DOI: 10.1371/Journal.Ppat.1006543  0.547
2017 Hong S, Wang D, Horton JR, Zhang X, Speck SH, Blumenthal RM, Cheng X. Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta. Nucleic Acids Research. PMID 28158710 DOI: 10.1093/Nar/Gkx057  0.33
2016 Wakeman BS, Izumiya Y, Speck SH. Identification of novel KSHV Orf50 transcripts: discovery of new RTA isoforms with variable transactivation potential. Journal of Virology. PMID 27795414 DOI: 10.1128/Jvi.01434-16  0.501
2015 O'Flaherty BM, Matar CG, Wakeman BS, Garcia A, Wilke CA, Courtney CL, Moore BB, Speck SH. CD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice. Plos One. 10: e0135719. PMID 26317335 DOI: 10.1371/Journal.Pone.0135719  0.446
2015 Matar CG, Jacobs NT, Speck SH, Lamb TJ, Moormann AM. Does EBV alter the pathogenesis of malaria? Parasite Immunology. 37: 433-445. PMID 26121587 DOI: 10.1111/Pim.12212  0.418
2015 Matar CG, Anthony NR, O'Flaherty BM, Jacobs NT, Priyamvada L, Engwerda CR, Speck SH, Lamb TJ. Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity. Plos Pathogens. 11: e1004858. PMID 25996913 DOI: 10.1371/Journal.Ppat.1004858  0.446
2015 Pinelli DF, Wakeman BS, Wagener ME, Speck SH, Ford ML. Rapamycin ameliorates the CTLA4-Ig-mediated defect in CD8(+) T cell immunity during gammaherpesvirus infection. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 15: 2576-87. PMID 25989700 DOI: 10.1111/Ajt.13326  0.382
2015 Collins CM, Speck SH. Interleukin 21 signaling in B cells is required for efficient establishment of murine gammaherpesvirus latency. Plos Pathogens. 11: e1004831. PMID 25875847 DOI: 10.1371/Journal.Ppat.1004831  0.474
2014 Rangaswamy US, O'Flaherty BM, Speck SH. Tyrosine 129 of the murine gammaherpesvirus M2 protein is critical for M2 function in vivo. Plos One. 9: e105197. PMID 25122496 DOI: 10.1371/Journal.Pone.0105197  0.52
2014 O'Flaherty BM, Soni T, Wakeman BS, Speck SH. The murine gammaherpesvirus immediate-early Rta synergizes with IRF4, targeting expression of the viral M1 superantigen to plasma cells. Plos Pathogens. 10: e1004302. PMID 25101696 DOI: 10.1371/Journal.Ppat.1004302  0.531
2014 Matar CG, Rangaswamy US, Wakeman BS, Iwakoshi N, Speck SH. Murine gammaherpesvirus 68 reactivation from B cells requires IRF4 but not XBP-1. Journal of Virology. 88: 11600-10. PMID 25078688 DOI: 10.1128/Jvi.01876-14  0.512
2014 Reese TA, Wakeman BS, Choi HS, Hufford MM, Huang SC, Zhang X, Buck MD, Jezewski A, Kambal A, Liu CY, Goel G, Murray PJ, Xavier RJ, Kaplan MH, Renne R, ... Speck SH, et al. Coinfection. Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter. Science (New York, N.Y.). 345: 573-7. PMID 24968940 DOI: 10.1126/Science.1254517  0.445
2014 Kaiser WJ, Daley-Bauer LP, Thapa RJ, Mandal P, Berger SB, Huang C, Sundararajan A, Guo H, Roback L, Speck SH, Bertin J, Gough PJ, Balachandran S, Mocarski ES. RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition. Proceedings of the National Academy of Sciences of the United States of America. 111: 7753-8. PMID 24821786 DOI: 10.1073/Pnas.1401857111  0.339
2014 Collins CM, Speck SH. Expansion of murine gammaherpesvirus latently infected B cells requires T follicular help. Plos Pathogens. 10: e1004106. PMID 24789087 DOI: 10.1371/Journal.Ppat.1004106  0.558
2014 Scott FM, Speck SH. A tissue culture model of murine gammaherpesvirus replication reveals roles for the viral cyclin in both virus replication and egress from infected cells. Plos One. 9: e93871. PMID 24695529 DOI: 10.1371/Journal.Pone.0093871  0.498
2014 Wakeman BS, Johnson LS, Paden CR, Gray KS, Virgin HW, Speck SH. Identification of alternative transcripts encoding the essential murine gammaherpesvirus lytic transactivator RTA. Journal of Virology. 88: 5474-90. PMID 24574412 DOI: 10.1128/Jvi.03110-13  0.583
2014 Rangaswamy US, Speck SH. Murine gammaherpesvirus M2 protein induction of IRF4 via the NFAT pathway leads to IL-10 expression in B cells. Plos Pathogens. 10: e1003858. PMID 24391506 DOI: 10.1371/Journal.Ppat.1003858  0.469
2013 Beus JM, Hashmi SS, Selvaraj SA, Duan D, Stempora LL, Monday SA, Cheeseman JA, Hamby KM, Speck SH, Larsen CP, Kirk AD, Kean LS. Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection. Plos One. 8: e71221. PMID 23940724 DOI: 10.1371/Journal.Pone.0071221  0.442
2013 Liang X, Crepeau RL, Zhang W, Speck SH, Usherwood EJ. CD4 and CD8 T cells directly recognize murine gammaherpesvirus 68-immortalized cells and prevent tumor outgrowth. Journal of Virology. 87: 6051-4. PMID 23514885 DOI: 10.1128/Jvi.00375-13  0.414
2013 Krug LT, Evans AG, Gargano LM, Paden CR, Speck SH. The absence of M1 leads to increased establishment of murine gammaherpesvirus 68 latency in IgD-negative B cells. Journal of Virology. 87: 3597-604. PMID 23302876 DOI: 10.1128/Jvi.01953-12  0.5
2012 Stahl JA, Paden CR, Chavan SS, MacLeod V, Edmondson RD, Speck SH, Forrest JC. Amplification of JNK signaling is necessary to complete the murine gammaherpesvirus 68 lytic replication cycle. Journal of Virology. 86: 13253-62. PMID 23015701 DOI: 10.1128/Jvi.01432-12  0.464
2012 Paden CR, Forrest JC, Tibbetts SA, Speck SH. Unbiased mutagenesis of MHV68 LANA reveals a DNA-binding domain required for LANA function in vitro and in vivo. Plos Pathogens. 8: e1002906. PMID 22969427 DOI: 10.1371/Journal.Ppat.1002906  0.409
2012 Gray KS, Collins CM, Speck SH. Characterization of omental immune aggregates during establishment of a latent gammaherpesvirus infection. Plos One. 7: e43196. PMID 22952645 DOI: 10.1371/Journal.Pone.0043196  0.509
2012 Collins CM, Speck SH. Tracking murine gammaherpesvirus 68 infection of germinal center B cells in vivo. Plos One. 7: e33230. PMID 22427999 DOI: 10.1371/Journal.Pone.0033230  0.532
2011 Liang X, Paden CR, Morales FM, Powers RP, Jacob J, Speck SH. Murine gamma-herpesvirus immortalization of fetal liver-derived B cells requires both the viral cyclin D homolog and latency-associated nuclear antigen. Plos Pathogens. 7: e1002220. PMID 21931547 DOI: 10.1371/Journal.Ppat.1002220  0.594
2011 Barton E, Mandal P, Speck SH. Pathogenesis and host control of gammaherpesviruses: lessons from the mouse. Annual Review of Immunology. 29: 351-97. PMID 21219186 DOI: 10.1146/Annurev-Immunol-072710-081639  0.528
2011 Herskowitz JH, Jacoby MA, Speck SH. The murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cells (Journal of Virology (2005) 79, 4, (2261-2273)) Journal of Virology. 85: 3041. DOI: 10.1128/JVI.00066-11  0.702
2010 Speck SH, Ganem D. Viral latency and its regulation: lessons from the gamma-herpesviruses. Cell Host & Microbe. 8: 100-15. PMID 20638646 DOI: 10.1016/J.Chom.2010.06.014  0.485
2010 Krug LT, Torres-González E, Qin Q, Sorescu D, Rojas M, Stecenko A, Speck SH, Mora AL. Inhibition of NF-kappaB signaling reduces virus load and gammaherpesvirus-induced pulmonary fibrosis. The American Journal of Pathology. 177: 608-21. PMID 20566741 DOI: 10.2353/Ajpath.2010.091122  0.456
2010 Paden CR, Forrest JC, Moorman NJ, Speck SH. Murine gammaherpesvirus 68 LANA is essential for virus reactivation from splenocytes but not long-term carriage of viral genome. Journal of Virology. 84: 7214-24. PMID 20444892 DOI: 10.1128/Jvi.00133-10  0.526
2010 Gray KS, Forrest JC, Speck SH. The de novo methyltransferases DNMT3a and DNMT3b target the murine gammaherpesvirus immediate-early gene 50 promoter during establishment of latency. Journal of Virology. 84: 4946-59. PMID 20200245 DOI: 10.1128/Jvi.00060-10  0.558
2010 Siegel AM, Rangaswamy US, Napier RJ, Speck SH. Blimp-1-dependent plasma cell differentiation is required for efficient maintenance of murine gammaherpesvirus latency and antiviral antibody responses. Journal of Virology. 84: 674-85. PMID 19889763 DOI: 10.1128/Jvi.01306-09  0.543
2010 Beus J, Hamby K, Kirk AD, Larsen CP, Speck SH, Kean L. Identification of a Costimulation Blockade Resistant Mechanism of Bone Marrow Allograft Rejection Induced by Infection with a Murine EBV Homologue. Blood. 116: 1461-1461. DOI: 10.1182/Blood.V116.21.1461.1461  0.45
2009 Liang X, Collins CM, Mendel JB, Iwakoshi NN, Speck SH. Gammaherpesvirus-driven plasma cell differentiation regulates virus reactivation from latently infected B lymphocytes. Plos Pathogens. 5: e1000677. PMID 19956661 DOI: 10.1371/Journal.Ppat.1000677  0.59
2009 Collins CM, Boss JM, Speck SH. Identification of infected B-cell populations by using a recombinant murine gammaherpesvirus 68 expressing a fluorescent protein. Journal of Virology. 83: 6484-93. PMID 19386718 DOI: 10.1128/Jvi.00297-09  0.58
2009 Krug LT, Collins CM, Gargano LM, Speck SH. NF-kappaB p50 plays distinct roles in the establishment and control of murine gammaherpesvirus 68 latency. Journal of Virology. 83: 4732-48. PMID 19264770 DOI: 10.1128/Jvi.00111-09  0.503
2009 Gargano LM, Forrest JC, Speck SH. Signaling through Toll-like receptors induces murine gammaherpesvirus 68 reactivation in vivo. Journal of Virology. 83: 1474-82. PMID 19019960 DOI: 10.1128/Jvi.01717-08  0.52
2009 Gray KS, Allen RD, Farrell ML, Forrest JC, Speck SH. Alternatively initiated gene 50/RTA transcripts expressed during murine and human gammaherpesvirus reactivation from latency. Journal of Virology. 83: 314-28. PMID 18971285 DOI: 10.1128/Jvi.01444-08  0.611
2008 Forrest JC, Speck SH. Establishment of B-cell lines latently infected with reactivation-competent murine gammaherpesvirus 68 provides evidence for viral alteration of a DNA damage-signaling cascade. Journal of Virology. 82: 7688-99. PMID 18495760 DOI: 10.1128/Jvi.02689-07  0.53
2008 DeZalia M, Speck SH. Identification of closely spaced but distinct transcription initiation sites for the murine gammaherpesvirus 68 latency-associated M2 gene. Journal of Virology. 82: 7411-21. PMID 18480430 DOI: 10.1128/Jvi.00651-08  0.44
2008 Siegel AM, Herskowitz JH, Speck SH. The MHV68 M2 protein drives IL-10 dependent B cell proliferation and differentiation. Plos Pathogens. 4: e1000039. PMID 18389062 DOI: 10.1371/Journal.Ppat.1000039  0.418
2008 Evans AG, Moser JM, Krug LT, Pozharskaya V, Mora AL, Speck SH. A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology. The Journal of Experimental Medicine. 205: 669-84. PMID 18332178 DOI: 10.1084/Jem.20071135  0.476
2008 Stapler D, Lee ED, Selvaraj SA, Evans AG, Kean LS, Speck SH, Larsen CP, Gangappa S. Expansion of effector memory TCR Vbeta4+ CD8+ T cells is associated with latent infection-mediated resistance to transplantation tolerance. Journal of Immunology (Baltimore, Md. : 1950). 180: 3190-200. PMID 18292543 DOI: 10.4049/Jimmunol.180.5.3190  0.507
2008 Gargano LM, Moser JM, Speck SH. Role for MyD88 signaling in murine gammaherpesvirus 68 latency. Journal of Virology. 82: 3853-63. PMID 18256152 DOI: 10.1128/Jvi.02577-07  0.449
2008 Herskowitz JH, Siegel AM, Jacoby MA, Speck SH. Systematic mutagenesis of the murine gammaherpesvirus 68 M2 protein identifies domains important for chronic infection. Journal of Virology. 82: 3295-310. PMID 18234799 DOI: 10.1128/Jvi.02234-07  0.704
2007 Forrest JC, Paden CR, Allen RD, Collins J, Speck SH. ORF73-null murine gammaherpesvirus 68 reveals roles for mLANA and p53 in virus replication. Journal of Virology. 81: 11957-71. PMID 17699571 DOI: 10.1128/Jvi.00111-07  0.543
2007 Allen RD, DeZalia MN, Speck SH. Identification of an Rta responsive promoter involved in driving gammaHV68 v-cyclin expression during virus replication. Virology. 365: 250-9. PMID 17477952 DOI: 10.1016/J.Virol.2007.03.021  0.516
2007 Mora AL, Torres-González E, Rojas M, Xu J, Ritzenthaler J, Speck SH, Roman J, Brigham K, Stecenko A. Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice. American Journal of Respiratory and Critical Care Medicine. 175: 1139-50. PMID 17363768 DOI: 10.1164/Rccm.200610-1426Oc  0.363
2007 Krug LT, Moser JM, Dickerson SM, Speck SH. Inhibition of NF-kappaB activation in vivo impairs establishment of gammaherpesvirus latency. Plos Pathogens. 3: e11. PMID 17257062 DOI: 10.1371/Journal.Ppat.0030011  0.537
2006 Upton JW, Speck SH. Evidence for CDK-dependent and CDK-independent functions of the murine gammaherpesvirus 68 v-cyclin. Journal of Virology. 80: 11946-59. PMID 17005668 DOI: 10.1128/Jvi.01722-06  0.469
2006 McClellan KB, Gangappa S, Speck SH, Virgin HW. Antibody-independent control of gamma-herpesvirus latency via B cell induction of anti-viral T cell responses. Plos Pathogens. 2: e58. PMID 16789842 DOI: 10.1371/Journal.Ppat.0020058  0.511
2006 Kersh EN, Fitzpatrick DR, Murali-Krishna K, Shires J, Speck SH, Boss JM, Ahmed R. Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 176: 4083-93. PMID 16547244 DOI: 10.4049/Jimmunol.176.7.4083  0.406
2006 Allen RD, Dickerson S, Speck SH. Identification of spliced gammaherpesvirus 68 LANA and v-cyclin transcripts and analysis of their expression in vivo during latent infection Journal of Virology. 80: 2055-2062. PMID 16439562 DOI: 10.1128/Jvi.80.4.2055-2062.2006  0.546
2006 Moser JM, Farrell ML, Krug LT, Upton JW, Speck SH. A gammaherpesvirus 68 gene 50 null mutant establishes long-term latency in the lung but fails to vaccinate against a wild-type virus challenge. Journal of Virology. 80: 1592-8. PMID 16415035 DOI: 10.1128/Jvi.80.3.1592-1598.2006  0.563
2006 Evans AG, Moorman NJ, Willer DO, Speck SH. The M4 gene of gammaHV68 encodes a secreted glycoprotein and is required for the efficient establishment of splenic latency. Virology. 344: 520-31. PMID 16185740 DOI: 10.1016/J.Virol.2005.08.020  0.495
2005 Tarakanova VL, Suarez F, Tibbetts SA, Jacoby MA, Weck KE, Hess JL, Speck SH, Virgin HW. Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice. Journal of Virology. 79: 14668-79. PMID 16282467 DOI: 10.1128/Jvi.79.23.14668-14679.2005  0.714
2005 Loh J, Huang Q, Petros AM, Nettesheim D, van Dyk LF, Labrada L, Speck SH, Levine B, Olejniczak ET, Virgin HW. A surface groove essential for viral Bcl-2 function during chronic infection in vivo. Plos Pathogens. 1: e10. PMID 16201011 DOI: 10.1371/Journal.Ppat.0010010  0.345
2005 Upton JW, van Dyk LF, Speck SH. Characterization of murine gammaherpesvirus 68 v-cyclin interactions with cellular cdks. Virology. 341: 271-83. PMID 16102793 DOI: 10.1016/J.Virol.2005.07.014  0.356
2005 Moser JM, Upton JW, Allen RD, Wilson CB, Speck SH. Role of B-cell proliferation in the establishment of gammaherpesvirus latency. Journal of Virology. 79: 9480-91. PMID 16014911 DOI: 10.1128/Jvi.79.15.9480-9491.2005  0.574
2005 Moser JM, Upton JW, Gray KS, Speck SH. Ex vivo stimulation of B cells latently infected with gammaherpesvirus 68 triggers reactivation from latency. Journal of Virology. 79: 5227-31. PMID 15795307 DOI: 10.1128/Jvi.79.8.5227-5231.2005  0.565
2005 Mora AL, Woods CR, Garcia A, Xu J, Rojas M, Speck SH, Roman J, Brigham KL, Stecenko AA. Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice. American Journal of Physiology. Lung Cellular and Molecular Physiology. 289: L711-21. PMID 15734789 DOI: 10.1152/Ajplung.00007.2005  0.378
2005 Willer DO, Speck SH. Establishment and maintenance of long-term murine gammaherpesvirus 68 latency in B cells in the absence of CD40. Journal of Virology. 79: 2891-9. PMID 15709008 DOI: 10.1128/Jvi.79.5.2891-2899.2005  0.505
2005 Pavlova I, Lin CY, Speck SH. Murine gammaherpesvirus 68 Rta-dependent activation of the gene 57 promoter. Virology. 333: 169-79. PMID 15708602 DOI: 10.1016/J.Virol.2004.12.021  0.711
2005 Braaten DC, Sparks-Thissen RL, Kreher S, Speck SH, Virgin HW. An optimized CD8+ T-cell response controls productive and latent gammaherpesvirus infection. Journal of Virology. 79: 2573-83. PMID 15681457 DOI: 10.1128/JVI.79.4.2573-2583.2005  0.34
2005 Herskowitz JH, Herskowitz J, Jacoby MA, Speck SH. The murine gammaherpesvirus 68 M2 gene is required for efficient reactivation from latently infected B cells. Journal of Virology. 79: 2261-73. PMID 15681428 DOI: 10.1128/Jvi.79.4.2261-2273.2005  0.749
2004 Elliott J, Goodhew EB, Krug LT, Shakhnovsky N, Yoo L, Speck SH. Variable methylation of the Epstein-Barr virus Wp EBNA gene promoter in B-lymphoblastoid cell lines. Journal of Virology. 78: 14062-5. PMID 15564516 DOI: 10.1128/Jvi.78.24.14062-14065.2004  0.8
2004 Moorman NJ, Lin CY, Speck SH. Identification of candidate gammaherpesvirus 68 genes required for virus replication by signature-tagged transposon mutagenesis. Journal of Virology. 78: 10282-90. PMID 15367594 DOI: 10.1128/Jvi.78.19.10282-10290.2004  0.483
2004 Sparks-Thissen RL, Braaten DC, Kreher S, Speck SH, Virgin HW. An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infection. Journal of Virology. 78: 6827-35. PMID 15194758 DOI: 10.1128/JVI.78.13.6827-6835.2004  0.326
2003 Moorman NJ, Willer DO, Speck SH. The gammaherpesvirus 68 latency-associated nuclear antigen homolog is critical for the establishment of splenic latency. Journal of Virology. 77: 10295-303. PMID 12970414 DOI: 10.1128/Jvi.77.19.10295-10303.2003  0.557
2003 Willer DO, Speck SH. Long-term latent murine Gammaherpesvirus 68 infection is preferentially found within the surface immunoglobulin D-negative subset of splenic B cells in vivo. Journal of Virology. 77: 8310-21. PMID 12857900 DOI: 10.1128/Jvi.77.15.8310-8321.2003  0.51
2003 Tibbetts SA, Loh J, Van Berkel V, McClellan JS, Jacoby MA, Kapadia SB, Speck SH, Virgin HW. Establishment and maintenance of gammaherpesvirus latency are independent of infective dose and route of infection. Journal of Virology. 77: 7696-701. PMID 12805472 DOI: 10.1128/Jvi.77.13.7696-7701.2003  0.692
2003 Liu P, Speck SH. Synergistic autoactivation of the Epstein-Barr virus immediate-early BRLF1 promoter by Rta and Zta. Virology. 310: 199-206. PMID 12781707 DOI: 10.1016/S0042-6822(03)00145-4  0.503
2003 Pavlova IV, Virgin HW, Speck SH. Disruption of gammaherpesvirus 68 gene 50 demonstrates that Rta is essential for virus replication. Journal of Virology. 77: 5731-9. PMID 12719566 DOI: 10.1128/Jvi.77.10.5731-5739.2003  0.711
2003 van Dyk LF, Virgin HW, Speck SH. Maintenance of gammaherpesvirus latency requires viral cyclin in the absence of B lymphocytes. Journal of Virology. 77: 5118-26. PMID 12692214 DOI: 10.1128/Jvi.77.9.5118-5126.2003  0.539
2003 Moorman NJ, Virgin HW, Speck SH. Disruption of the gene encoding the gammaHV68 v-GPCR leads to decreased efficiency of reactivation from latency. Virology. 307: 179-90. PMID 12667789 DOI: 10.1016/S0042-6822(02)00023-5  0.533
2002 Yoo LI, Woloszynek J, Templeton S, Speck SH. Deletion of Epstein-Barr virus regulatory sequences upstream of the EBNA gene promoter Wp1 is unfavorable for B-Cell immortalization. Journal of Virology. 76: 11763-9. PMID 12388739 DOI: 10.1128/Jvi.76.22.11763-11769.2002  0.789
2002 Gangappa S, Kapadia SB, Speck SH, Virgin HW. Antibody to a lytic cycle viral protein decreases gammaherpesvirus latency in B-cell-deficient mice. Journal of Virology. 76: 11460-8. PMID 12388707 DOI: 10.1128/Jvi.76.22.11460-11468.2002  0.529
2002 Speck SH. EBV framed in Burkitt lymphoma. Nature Medicine. 8: 1086-7. PMID 12357244 DOI: 10.1038/Nm1002-1086  0.482
2002 Kapadia SB, Levine B, Speck SH, Virgin HW. Critical role of complement and viral evasion of complement in acute, persistent, and latent gamma-herpesvirus infection. Immunity. 17: 143-55. PMID 12196286 DOI: 10.1016/S1074-7613(02)00369-2  0.436
2002 Paulson EJ, Fingeroth JD, Yates JL, Speck SH. Methylation of the EBV genome and establishment of restricted latency in low-passage EBV-infected 293 epithelial cells. Virology. 299: 109-21. PMID 12167346 DOI: 10.1006/Viro.2002.1457  0.51
2002 Tibbetts SA, van Dyk LF, Speck SH, Virgin HW. Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus. Journal of Virology. 76: 7125-32. PMID 12072512 DOI: 10.1128/JVI.76.14.7125-7132.2002  0.383
2002 Clambey ET, Virgin HW, Speck SH. Characterization of a spontaneous 9.5-kilobase-deletion mutant of murine gammaherpesvirus 68 reveals tissue-specific genetic requirements for latency. Journal of Virology. 76: 6532-44. PMID 12050366 DOI: 10.1128/Jvi.76.13.6532-6544.2002  0.477
2002 Gangappa S, van Dyk LF, Jewett TJ, Speck SH, Virgin HW. Identification of the in vivo role of a viral bcl-2. The Journal of Experimental Medicine. 195: 931-40. PMID 11927636 DOI: 10.1084/Jem.20011825  0.491
2002 van Berkel V, Levine B, Kapadia SB, Goldman JE, Speck SH, Virgin HW. Critical role for a high-affinity chemokine-binding protein in gamma-herpesvirus-induced lethal meningitis. The Journal of Clinical Investigation. 109: 905-14. PMID 11927617 DOI: 10.1172/Jci14358  0.427
2002 Jacoby MA, Virgin HW, Speck SH. Disruption of the M2 gene of murine gammaherpesvirus 68 alters splenic latency following intranasal, but not intraperitoneal, inoculation. Journal of Virology. 76: 1790-801. PMID 11799175 DOI: 10.1128/Jvi.76.4.1790-1801.2002  0.711
2001 Dal Canto AJ, Swanson PE, O'Guin AK, Speck SH, Virgin HW. IFN-γ action in the media of the great elastic arteries, a novel immunoprivileged site Journal of Clinical Investigation. 107. PMID 11160143 DOI: 10.1172/Jci11540  0.427
2000 Dal Canto AJ, Virgin IV HW, Speck SH. Ongoing viral replication is required for gammaherpesvirus 68-Induced vascular damage Journal of Virology. 74: 11304-11310. PMID 11070030 DOI: 10.1128/Jvi.74.23.11304-11310.2000  0.429
2000 Yoo L, Speck SH. Determining the role of the Epstein-Barr virus Cp EBNA2-dependent enhancer during the establishment of latency by using mutant and wild-type viruses recovered from cottontop marmoset lymphoblastoid cell lines Journal of Virology. 74: 11115-11120. PMID 11070007 DOI: 10.1128/Jvi.74.23.11115-11120.2000  0.828
2000 Van Dyk LF, Virgin IV HW, Speck SH. The murine gammaherpesvirus 68 v-cyclin is a critical regulator of reactivation from latency Journal of Virology. 74: 7451-7461. PMID 10906198 DOI: 10.1128/JVI.74.16.7451-7461.2000  0.375
2000 Kung C, Pingel JT, Heikinheimo M, Klemola T, Varkila K, Yoo LI, Vuopala K, Poyhonen M, Uhari M, Rogers M, Speck SH, Chatila T, Thomas ML. Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease. Nature Medicine. 6: 343-5. PMID 10700239 DOI: 10.1038/73208  0.758
2000 Liu S, Pavlova IV, Virgin HW, Speck SH. Characterization of gammaherpesvirus 68 gene 50 transcription. Journal of Virology. 74: 2029-37. PMID 10644377 DOI: 10.1128/Jvi.74.4.2029-2037.2000  0.622
2000 Clambey ET, Virgin IV HW, Speck SH. Disruption of the murine gammaherpesvirus 68 M1 open reading frame leads to enhanced reactivation from latency Journal of Virology. 74: 1973-1984. PMID 10644370 DOI: 10.1128/Jvi.74.4.1973-1984.2000  0.467
1999 Paulson EJ, Speck SH. Differential methylation of Epstein-Barr virus latency promoters facilitates viral persistence in healthy seropositive individuals Journal of Virology. 73: 9959-9968. PMID 10559309 DOI: 10.1128/Jvi.73.12.9959-9968.1999  0.516
1999 Speck SH, Virgin IV HW. Host and viral genetics of chronic infection: A mouse model of gamma- herpesvirus pathogenesis Current Opinion in Microbiology. 2: 403-409. PMID 10458986 DOI: 10.1016/S1369-5274(99)80071-X  0.316
1999 Virgin IV HW, Speck SH. Unraveling immunity to γ-herpesviruses: A new model for understanding the role of immunity in chronic virus infection Current Opinion in Immunology. 11: 371-379. PMID 10448140 DOI: 10.1016/S0952-7915(99)80063-6  0.462
1999 Kapadia SB, Molina H, Van Berkel V, Speck SH, Virgin IV HW. Murine gammaherpesvirus 68 encodes a functional regulator of complement activation Journal of Virology. 73: 7658-7670. PMID 10438856 DOI: 10.1128/Jvi.73.9.7658-7670.1999  0.472
1999 van Dyk LF, Hess JL, Katz JD, Jacoby M, Speck SH, Virgin HW IV. The murine gammaherpesvirus 68 v-cyclin gene is an oncogene that promotes cell cycle progression in primary lymphocytes. Journal of Virology. 73: 5110-22. PMID 10233974 DOI: 10.1128/Jvi.73.6.5110-5122.1999  0.687
1999 Weck KE, Kim SS, Virgin IV HW, Speck SH. B cells regulate murine gammaherpesvirus 68 latency Journal of Virology. 73: 4651-4661. PMID 10233924  0.405
1999 Van Berkel V, Preiter K, Virgin IV HW, Speck SH. Identification and initial characterization of the murine gammaherpesvirus 68 gene M3, encoding an abundantly secreted protein Journal of Virology. 73: 4524-4529. PMID 10196360 DOI: 10.1128/Jvi.73.5.4524-4529.1999  0.383
1999 Weck KE, Kim SS, Virgin IV HW, Speck SH. Macrophages are the major reservoir of latent murine gammaherpesvirus 68 in peritoneal cells Journal of Virology. 73: 3273-3283. PMID 10074181  0.346
1999 Virgin IV HW, Presti RM, Li XY, Liu C, Speck SH. Three distinct regions of the murine gammaherpesvirus 68 genome are transcriptionally active in latently infected mice Journal of Virology. 73: 2321-2332. PMID 9971815 DOI: 10.1128/Jvi.73.3.2321-2332.1999  0.544
1999 Kapadia SB, Molina H, van Berkel V, Speck SH, Virgin HW. Murine Gammaherpesvirus 68 Encodes a Functional Regulator of Complement Activation Journal of Virology. 73: 7658-7670. DOI: 10.1128/jvi.73.9.7658-7670.1999  0.381
1998 Liu P, Liu S, Speck SH. Identification of a negative cis element within the ZII domain of the Epstein-Barr virus lytic switch BZLF1 gene promoter Journal of Virology. 72: 8230-8239. PMID 9733866 DOI: 10.1128/Jvi.72.10.8230-8239.1998  0.403
1997 Weck KE, Dal Canto AJ, Gould JD, O'Guin AK, Roth KA, Saffitz JE, Speck SH, Virgin HW. Murine gamma-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-gamma responsiveness: a new model for virus-induced vascular disease. Nature Medicine. 3: 1346-53. PMID 9396604 DOI: 10.1038/nm1297-1346  0.328
1997 Yoo LI, Mooney M, Puglielli MT, Speck SH. B-cell lines immortalized with an Epstein-Barr virus mutant lacking the Cp EBNA2 enhancer are biased toward utilization of the oriP-proximal EBNA gene promoter Wp1. Journal of Virology. 71: 9134-42. PMID 9371570 DOI: 10.1128/Jvi.71.12.9134-9142.1997  0.813
1997 Speck SH, Chatlla T, Flemington E. Reactivation of Epstein-Barr virus: Regulation and function of the BZLF1 gene Trends in Microbiology. 5: 399-405. PMID 9351176 DOI: 10.1016/S0966-842X(97)01129-3  0.465
1997 Chatila T, Ho N, Liu P, Liu S, Mosialos G, Kieff E, Speck SH. The Epstein-Barr virus-induced Ca2+/calmodulin-dependent kinase type IV/Gr promotes a Ca(2+)-dependent switch from latency to viral replication. Journal of Virology. 71: 6560-7. PMID 9261377 DOI: 10.1128/Jvi.71.9.6560-6567.1997  0.372
1997 Virgin HW, Latreille P, Wamsley P, Hallsworth K, Weck KE, Dal Canto AJ, Speck SH. Complete sequence and genomic analysis of murine gammaherpesvirus 68. Journal of Virology. 71: 5894-904. PMID 9223479  0.306
1997 Schaefer BC, Paulson E, Strominger JL, Speck SH. Constitutive activation of epstein-barr virus (EBV) nuclear antigen 1 gene transcription by IRF1 and IRF2 during restricted EBV latency Molecular and Cellular Biology. 17: 873-886. PMID 9001242 DOI: 10.1128/Mcb.17.2.873  0.399
1997 Puglielli MT, Desai N, Speck SH. Regulation of EBNA gene transcription in lymphoblastoid cell lines: Characterization of sequences downstream of BCR2 (Cp) Journal of Virology. 71: 120-128. PMID 8985330  0.366
1996 Schaefer BC, Strominger JL, Speck SH. A simple reverse transcriptase PCR assay to distinguish EBNA1 gene transcripts associated with type I and II latency from those arising during induction of the viral lytic cycle Journal of Virology. 70: 8204-8208. PMID 8892954 DOI: 10.1128/Jvi.70.11.8204-8208.1996  0.528
1996 Weck KE, Barkon ML, Yoo LI, Speck SH, Virgin HW IV. Mature B cells are required for acute splenic infection, but not for establishment of latency, by murine gammaherpesvirus 68. Journal of Virology. 70: 6775-80. PMID 8794315 DOI: 10.1128/Jvi.70.10.6775-6780.1996  0.811
1996 Puglielli MT, Woisetschlaeger M, Speck SH. oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines Journal of Virology. 70: 5758-5768. PMID 8709191 DOI: 10.1128/Jvi.70.9.5758-5768.1996  0.488
1996 Schlager S, Speck SH, Woisetschlger M. Transcription of the Epstein-Barr virus nuclear antigen 1 (EBNA1) gene occurs before induction of the BCR2 (Cp) EBNA gene promoter during the initial stages of infection in B cells Journal of Virology. 70: 3561-3570. PMID 8648690  0.542
1995 Schaefer BC, Strominger JL, Speck SH. The Epstein-Barr virus BamHI F promoter is an early lytic promoter: Lack of correlation with EBNA 1 gene transcription in group 1 Burkitt's lymphoma cell lines Journal of Virology. 69: 5039-5047. PMID 7609074 DOI: 10.1128/Jvi.69.8.5039-5047.1995  0.468
1995 Goldfeld AE, Liu P, Liu S, Flemington EK, Strominger JL, Speck SH. Cyclosporin A and FK506 block induction of the Epstein-Barr virus lytic cycle by anti-immunoglobulin Virology. 209: 225-229. PMID 7538254 DOI: 10.1006/Viro.1995.1247  0.5
1995 Schaefer BC, Strominger JL, Speck SH. Redefining the Epstein-Barr virus-encoded nuclear antigen EBNA-1 gene promoter and transcription initiation site in group I Burkitt lymphoma cell lines Proceedings of the National Academy of Sciences of the United States of America. 92: 10565-10569. PMID 7479841 DOI: 10.1073/Pnas.92.23.10565  0.5
1995 Schaefer BC, Strominger JL, Speck SH. The Epstein-Barr virus BamHI F promoter is an early lytic promoter: lack of correlation with EBNA 1 gene transcription in group 1 Burkitt's lymphoma cell lines. Journal of Virology. 69: 5039-5047. DOI: 10.1128/jvi.69.8.5039-5047.1995  0.349
1994 Daibata M, Speck SH, Mulder C, Sairenji T. Regulation of the BZLF1 promoter of Epstein-Barr virus by second messengers in anti-immunoglobulin-treated B cells Virology. 198: 446-454. PMID 8291228 DOI: 10.1006/Viro.1994.1056  0.396
1994 Flemington EK, Lytle JP, Cayrol C, Borras AM, Speck SH. DNA-binding-defective mutants of the Epstein-Barr virus lytic switch activator Zta transactivate with altered specificities Molecular and Cellular Biology. 14: 3041-3052. PMID 8164660 DOI: 10.1128/Mcb.14.5.3041  0.329
1993 Flemington EK, Speck SH, Kaelin WG. E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product Proceedings of the National Academy of Sciences of the United States of America. 90: 6914-6918. PMID 8346196 DOI: 10.1073/Pnas.90.15.6914  0.388
1992 Yandava CN, Speck SH. Characterization of the deletion and rearrangement in the BamHI C region of the X50-7 epstein-barr virus genome, a mutant viral strain which exhibits constitutive BamHI W promoter activity Journal of Virology. 66: 5646-5650. PMID 1323716  0.478
1992 Jin XW, Speck SH. Identification of critical cis elements involved in mediating Epstein-Barr virus nuclear antigen 2-dependent activity of an enhancer located upstream of the viral BamHI C prompter Journal of Virology. 66: 2846-2852. PMID 1313905  0.434
1992 Goldfeld AE, Flemington EK, Boussiotis VA, Theodos CM, Titus RG, Strominger JL, Speck SH. Transcription of the tumor necrosis factor α gene is rapidly induced by anti-immunoglobulin and blocked by cyclosporin A and FK506 in human B cells Proceedings of the National Academy of Sciences of the United States of America. 89: 12198-12201. PMID 1281550 DOI: 10.1073/Pnas.89.24.12198  0.383
1991 Woisetschlaeger M, Jin XW, Yandava CN, Furmanski LA, Strominger JL, Speck SH. Role for the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infection Proceedings of the National Academy of Sciences of the United States of America. 88: 3942-3946. PMID 1850841 DOI: 10.1073/Pnas.88.9.3942  0.491
1991 Schaefer BC, Woisetschlaeger M, Strominger JL, Speck SH. Exclusive expression of Epstein-Barr virus nuclear antigen 1 in Burkitt lymphoma arises from a third promoter, distinct from the promoters used in latently infected lymphocytes Proceedings of the National Academy of Sciences of the United States of America. 88: 6550-6554. PMID 1713681 DOI: 10.1073/Pnas.88.15.6550  0.407
1991 Flemington EK, Goldfeld AE, Speck SH. Efficient transcription of the Epstein-Barr virus immediate-early BZLF1 and BRLF1 genes requires protein synthesis Journal of Virology. 65: 7073-7077. PMID 1658397 DOI: 10.1128/Jvi.65.12.7073-7077.1991  0.491
1991 Rogers RP, Strominger JL, Speck SH. Epstein-barr virus in b lymphocytes: Viral gene expression and function in latency Advances in Cancer Research. 58: 1-26. PMID 1312289 DOI: 10.1016/S0065-230X(08)60288-2  0.453
1990 Flemington E, Speck SH. Epstein-Barr virus BZLF1 trans activator induces the promoter of a cellular cognate gene, c-fos Journal of Virology. 64: 4549-4552. PMID 2166830 DOI: 10.1128/Jvi.64.9.4549-4552.1990  0.346
1990 Rogers RP, Woisetschlaeger M, Speck SH. Alternative splicing dictates translational start in Epstein - Barr virus transcripts Embo Journal. 9: 2273-2277. PMID 2162768  0.371
1990 Woisetschlaeger M, Yandava CN, Furmanski LA, Strominger JL, Speck SH. Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytes Proceedings of the National Academy of Sciences of the United States of America. 87: 1725-1729. PMID 2155423 DOI: 10.1073/Pnas.87.5.1725  0.593
1990 Flemington E, Speck SH. Autoregulation of Epstein-Barr virus putative lytic switch gene BZLF1 Journal of Virology. 64: 1227-1232. PMID 2154606 DOI: 10.1128/Jvi.64.3.1227-1232.1990  0.352
1990 Rogers RP, Speck SH. Bidirectional transcription of the Epstein-Barr virus major internal repeat Journal of Virology. 64: 2426-2429. PMID 1691315  0.432
1989 Woisetschlaeger M, Strominger JL, Speck SH. Mutually exclusive use of viral promoters in Epstein-Barr virus latently infected lymphocytes Proceedings of the National Academy of Sciences of the United States of America. 86: 6498-6502. PMID 2549539 DOI: 10.1073/Pnas.86.17.6498  0.422
1989 Rooney C, Howe JG, Speck SH, Miller G. Influences of Burkitt's lymphoma and primary B cells on latent gene expression by the nonimmortalizing P3J-HR-1 strain of Epstein-Barr virus Journal of Virology. 63: 1531-1539. PMID 2538644  0.5
1988 Austin PJ, Flemington E, Naidu Yandava C, Strominger JL, Speck SH. Complex transcription of the Epstein-Barr virus BamHI fragment H rightward open reading frame 1 (BHRF1) in latently and lytically infected B lymphocytes Proceedings of the National Academy of Sciences of the United States of America. 85: 3678-3682. PMID 2836854 DOI: 10.1073/Pnas.85.11.3678  0.448
1987 Quackenbush E, Clabby M, Gottesdiener KM, Barbosa J, Jones NH, Strominger JL, Speck S, Leiden JM. Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth. Proceedings of the National Academy of Sciences of the United States of America. 84: 6526-30. PMID 3476959 DOI: 10.1073/Pnas.84.18.6526  0.324
1987 Pfitzner AJ, Tsai EC, Strominger JL, Speck SH. Isolation and characterization of cDNA clones corresponding to transcripts from the BamHI H and F regions of the Epstein-Barr virus genome Journal of Virology. 61: 2902-2909. PMID 3039177  0.386
1987 Speck SH, Strominger JL. Epstein-Barr virus transformation Progress in Nucleic Acid Research and Molecular Biology. 34: 189-207. PMID 2830637 DOI: 10.1016/S0079-6603(08)60496-1  0.385
1987 Pfitzner AJ, Strominger JL, Speck SH. Characterization of a cDNA clone corresponding to a transcript from the Epstein-Barr virus BamHI M fragment: Evidence for overlapping mRNAs Journal of Virology. 61: 2943-2946. PMID 2441081  0.322
1987 Pfitzner AJ, Strominger JL, Speck SH. Characterization of a cDNA clone corresponding to a transcript from the Epstein-Barr virus BamHI M fragment: evidence for overlapping mRNAs. Journal of Virology. 61: 2943-2946. DOI: 10.1128/jvi.61.9.2943-2946.1987  0.305
1986 Speck SH, Pfizner A, Strominger JL. An Epstein-Barr virus transcript from a latently infected, growth-transformed B-cell line encodes a highly repetitive polypeptide Proceedings of the National Academy of Sciences of the United States of America. 83: 9298-9302. PMID 3025831 DOI: 10.1073/pnas.83.24.9298  0.401
1985 Speck SH, Strominger JL. Analysis of the transcript encoding the latent Epstein-Barr virus nuclear antigen I: A potentially polycistronic message generated by long-range splicing of several exons Proceedings of the National Academy of Sciences of the United States of America. 82: 8305-8309. PMID 3001694 DOI: 10.1073/Pnas.82.24.8305  0.488
1984 Cohen LK, Speck SH, Roberts BE, Strominger JL. Identification and mapping of polypeptides encoded by the P3HR-1 strain of Epstein-Barr virus Proceedings of the National Academy of Sciences of the United States of America. 81: 4183-4187. PMID 6330747 DOI: 10.1073/Pnas.81.13.4183  0.45
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