H Phillip Koeffler - Publications

Affiliations: 
University of California, Los Angeles, Los Angeles, CA 
Area:
Biomedical Engineering, Molecular Biology, Genetics

435 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Marijon H, Gery S, Chang H, Landesman Y, Shacham S, Lee DH, de Gramont A, Koeffler HP. Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status. Oncotarget. 12: 1749-1762. PMID 34504648 DOI: 10.18632/oncotarget.28047  0.55
2020 Chen Y, Xu L, Lin RY, Müschen M, Koeffler HP. Core transcriptional regulatory circuitries in cancer. Oncogene. PMID 32943730 DOI: 10.1038/S41388-020-01459-W  0.369
2020 Jeitany M, Prabhu A, Dakle P, Pathak E, Madan V, Kanojia D, Mukundan V, Jiang YY, Landesman Y, Tam WL, Kappei D, Koeffler HP. Novel carfilzomib-based combinations as potential therapeutic strategies for liposarcomas. Cellular and Molecular Life Sciences : Cmls. PMID 32851475 DOI: 10.1007/S00018-020-03620-W  0.327
2020 Jiang YY, Jiang Y, Li CQ, Zhang Y, Dakle P, Kaur H, Deng JW, Yu-Tong Lin R, Han L, Xie JJ, Yan Y, Doan N, Zheng Y, Mayakonda A, Hazawa M, ... ... Koeffler HP, et al. TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines. Gastroenterology. PMID 32619460 DOI: 10.1053/J.Gastro.2020.06.050  0.356
2020 Lim SL, Xu L, Han BC, Shyamsunder P, Chng WJ, Koeffler HP. Multiple myeloma: Combination therapy of BET proteolysis targeting chimeric molecule with CDK9 inhibitor. Plos One. 15: e0232068. PMID 32559187 DOI: 10.1371/Journal.Pone.0232068  0.385
2020 Pan J, Silva TC, Gull N, Yang Q, Plummer JT, Chen S, Daigo K, Hamakubo T, Gery S, Ding LW, Jiang YY, Hu S, Xu LY, Li EM, Ding Y, ... ... Koeffler HP, et al. Lineage-specific epigenomic and genomic activation of oncogene HNF4A promotes gastrointestinal adenocarcinomas. Cancer Research. PMID 32332020 DOI: 10.1158/0008-5472.Can-20-0390  0.344
2020 Kong LR, Mohamed Salleh NAB, Ong RW, Tan TZ, Syn NL, Goh RM, Fhu CW, Tan DSW, Iyer NG, Kannan S, Verma CS, Lim YC, Soo R, Ho J, Huang Y, ... ... Koeffler HP, et al. A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma. Nature Communications. 11: 1556. PMID 32214092 DOI: 10.1038/S41467-020-15318-5  0.385
2020 He J, Huang Z, He M, Liao J, Zhang Q, Wang S, Xie L, Ouyang L, Koeffler HP, Yin D, Liu A. Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas. Molecular Cancer. 19: 17. PMID 31992303 DOI: 10.1186/S12943-019-1120-1  0.318
2019 Lowry MB, Guo C, Zhang Y, Fantacone ML, Logan IE, Campbell Y, Zhang W, Le M, Indra AK, Ganguli-Indra G, Xie J, Gallo RL, Koeffler HP, Gombart AF. A mouse model for vitamin D-induced human cathelicidin antimicrobial peptide gene expression. The Journal of Steroid Biochemistry and Molecular Biology. 105552. PMID 31783153 DOI: 10.1016/J.Jsbmb.2019.105552  0.308
2019 Madan V, Li J, Zhou S, Teoh WW, Han L, Meggendorfer M, Malcovati L, Cazzola M, Ogawa S, Haferlach T, Yang H, Koeffler HP. Distinct and convergent consequences of splice factor mutations in myelodysplastic syndromes. American Journal of Hematology. PMID 31680297 DOI: 10.1002/Ajh.25673  0.311
2019 Huang M, Wang Y, Yang M, Yan J, Yang H, Zhuang W, Xu Y, Koeffler HP, Lin DC, Chen X. dbInDel: a database of enhancer-associated insertion and deletion variants by analysis of H3K27ac ChIP-Seq. Bioinformatics (Oxford, England). PMID 31603498 DOI: 10.1093/Bioinformatics/Btz770  0.351
2019 Loh XY, Sun QY, Ding LW, Mayakonda A, Venkatachalam N, Yeo MS, Silva TC, Xiao JF, B Doan N, W Said J, Ran XB, Zhou SQ, Dakle P, Shyamsunder P, Koh AP, ... ... Koeffler HP, et al. RNA-binding protein ZFP36L1 suppresses hypoxia and cell cycle signaling. Cancer Research. PMID 31551365 DOI: 10.1158/0008-5472.Can-18-2796  0.391
2019 Chen L, Huang M, Plummer J, Pan J, Jiang YY, Yang Q, Silva TC, Gull N, Chen S, Ding LW, An O, Yang H, Cheng Y, Said JW, Doan N, ... ... Koeffler HP, et al. Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma. Gut. PMID 31409603 DOI: 10.1136/Gutjnl-2019-318325  0.352
2019 Sun QY, Ding LW, Johnson K, Zhou S, Tyner JW, Yang H, Doan NB, Said JW, Xiao JF, Loh XY, Ran XB, Venkatachalam N, Lao Z, Chen Y, Xu L, ... ... Koeffler HP, et al. SOX7 regulates MAPK/ERK-BIM mediated apoptosis in cancer cells. Oncogene. PMID 31332289 DOI: 10.1038/S41388-019-0865-8  0.417
2019 Muraoka M, Akagi T, Ueda A, Wada T, Koeffler HP, Yokota T, Yachie A. C/EBPε ΔRS derived from a neutrophil-specific granule deficiency patient interacts with HDAC1 and its dysfunction is restored by trichostatin A. Biochemical and Biophysical Research Communications. 516: 293-299. PMID 31256937 DOI: 10.1016/J.Bbrc.2019.06.130  0.329
2019 Ding LW, Sun QY, Edwards JJ, Fernández LT, Ran XB, Zhou SQ, Scolyer RA, Wilmott JS, Thompson JF, Doan N, Said JW, Venkatachalam N, Xiao JF, Loh XY, Pein M, ... ... Koeffler HP, et al. LNK suppresses interferon signaling in melanoma. Nature Communications. 10: 2230. PMID 31110180 DOI: 10.1038/S41467-019-09711-Y  0.339
2019 Shyamsunder P, Shanmugasundaram M, Mayakonda A, Dakle P, Teoh WW, Han L, Kanojia D, Lim MC, Fullwood M, An O, Yang H, Jizhong S, Hossain MZ, Madan V, Koeffler HP. Identification of a novel enhancer of CEBPE essential for granulocytic differentiation. Blood. PMID 30952671 DOI: 10.1182/Blood.2018886077  0.383
2019 Hu K, Wu W, Li Y, Lin L, Chen D, Yan H, Xiao X, Chen H, Chen Z, Zhang Y, Xu S, Guo Y, Koeffler HP, Song E, Yin D. Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents. Embo Reports. PMID 30940648 DOI: 10.15252/Embr.201846166  0.381
2019 Chen Y, Xu L, Mayakonda A, Huang ML, Kanojia D, Tan TZ, Dakle P, Lin RY, Ke XY, Said JW, Chen J, Gery S, Ding LW, Jiang YY, Pang A, ... ... Koeffler HP, et al. Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma. Nature Communications. 10: 1353. PMID 30903020 DOI: 10.1038/S41467-019-09257-Z  0.341
2019 Han L, Madan V, Mayakonda A, Dakle P, Woon TW, Shyamsunder P, Nordin HBM, Cao Z, Sundaresan J, Lei I, Wang Z, Koeffler HP. Chromatin remodeling mediated by ARID1A is indispensable for normal hematopoiesis in mice. Leukemia. PMID 30858552 DOI: 10.1038/S41375-019-0438-4  0.357
2019 Lim SL, Damnernsawad A, Shyamsunder P, Chng WJ, Han BC, Xu L, Pan J, Pravin DP, Alkan S, Tyner JW, Koeffler HP. Proteolysis targeting chimeric molecules as therapy for multiple myeloma: efficacy, biomarker and drug combinations. Haematologica. PMID 30606790 DOI: 10.3324/Haematol.2018.201483  0.394
2018 Chien W, Sudo M, Ding LW, Sun QY, Wuensche P, Lee KL, Hattori N, Garg M, Xu L, Zheng Y, Gery S, Wongphayak S, Yang H, Baloglu E, Shacham S, ... ... Koeffler HP, et al. Functional Genome-wide Screening Identifies Targets and Pathways Sensitizing Pancreatic Cancer Cells to Dasatinib. Journal of Cancer. 9: 4762-4773. PMID 30588262 DOI: 10.7150/Jca.25138  0.367
2018 Lao ZT, Ding LW, An O, Hattori N, Sun QY, Tan KT, Mayakonda A, Chuan WG, Madan V, Lin DC, Yang H, Koeffler HP. Mutational and transcriptomic profiling of acute leukemia of ambiguous lineage reveals obscure but clinically important lineage bias. Haematologica. PMID 30514800 DOI: 10.3324/Haematol.2018.202911  0.336
2018 Lin L, Huang M, Shi X, Mayakonda A, Hu K, Jiang YY, Guo X, Chen L, Pang B, Doan N, Said JW, Xie J, Gery S, Cheng X, Lin Z, ... ... Koeffler HP, et al. Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1. Nucleic Acids Research. PMID 30496486 DOI: 10.1093/Nar/Gky1207  0.343
2018 Mayakonda A, Lin DC, Assenov Y, Plass C, Koeffler HP. Maftools: efficient and comprehensive analysis of somatic variants in cancer. Genome Research. PMID 30341162 DOI: 10.1101/Gr.239244.118  0.323
2018 Jiang Y, Jiang YY, Xie JJ, Mayakonda A, Hazawa M, Chen L, Xiao JF, Li CQ, Huang ML, Ding LW, Sun QY, Xu L, Kanojia D, Jeitany M, Deng JW, ... ... Koeffler HP, et al. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Nature Communications. 9: 3619. PMID 30190462 DOI: 10.1038/S41467-018-06081-9  0.391
2018 Subhash VV, Yeo MS, Wang L, Tan SH, Wong FY, Thuya WL, Tan WL, Peethala PC, Soe MY, Tan DSP, Padmanabhan N, Baloglu E, Shacham S, Tan P, Koeffler HP, et al. Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor. Scientific Reports. 8: 12248. PMID 30115935 DOI: 10.1038/S41598-018-30686-1  0.337
2018 Madan V, Han L, Hattori N, Teoh WW, Mayakonda A, Sun QY, Ding LW, Binte Mohd Nordin H, Lim SL, Shyamsunder P, Dakle P, Sundaresan J, Doan NB, Sanada M, Sato-Otsubo A, ... ... Koeffler HP, et al. ASXL2 regulates hematopoiesis in mice and its deficiency promotes myeloid expansion. Haematologica. PMID 30093396 DOI: 10.3324/Haematol.2018.189928  0.359
2018 Guo X, Zhang Y, Mayakonda A, Madan V, Ding LW, Lin LH, Zia S, Gery S, Tyner JW, Zhou W, Yin D, Lin DC, Koeffler HP. ARID1A and CEBPα cooperatively inhibit UCA1 transcription in breast cancer. Oncogene. PMID 29980791 DOI: 10.1038/S41388-018-0371-4  0.365
2018 Xiao JF, Sun QY, Ding LW, Chien W, Liu XY, Mayakanda A, Jiang YY, Loh XY, Ran XB, Doan NB, Castor B, Chia D, Said JW, Tan KT, Yang H, ... ... Koeffler HP, et al. The MYC/BMI1 axis is essential for SETDB1-mediated breast tumorigenesis. The Journal of Pathology. PMID 29926931 DOI: 10.1002/Path.5126  0.35
2018 Marijon H, Lee DH, Ding L, Sun H, Gery S, de Gramont A, Koeffler HP. Co-targeting poly(ADP-ribose) polymerase (PARP) and histone deacetylase (HDAC) in triple-negative breast cancer: Higher synergism in BRCA mutated cells. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 99: 543-551. PMID 29902865 DOI: 10.1016/J.Biopha.2018.01.045  0.548
2018 Shyamsunder P, Sankar H, Mayakonda A, Han L, Nordin HBM, Woon TW, Shanmugasundaram M, Dakle P, Madan V, Koeffler HP. CARD10, a CEBPE target involved in granulocytic differentiation. Haematologica. PMID 29773596 DOI: 10.3324/Haematol.2018.190280  0.391
2018 Xu L, Chen Y, Mayakonda A, Koh L, Chong YK, Buckley DL, Sandanaraj E, Lim SW, Lin RY, Ke XY, Huang ML, Chen J, Sun W, Wang LZ, Goh BC, ... ... Koeffler HP, et al. Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 29764999 DOI: 10.1073/Pnas.1712363115  0.352
2018 Evrard M, Kwok IWH, Chong SZ, Teng KWW, Becht E, Chen J, Sieow JL, Penny HL, Ching GC, Devi S, Adrover JM, Li JLY, Liong KH, Tan L, Poon Z, ... ... Koeffler HP, et al. Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions. Immunity. 48: 364-379.e8. PMID 29466759 DOI: 10.1016/J.Immuni.2018.02.002  0.31
2018 Xie JJ, Jiang YY, Jiang Y, Li CQ, Chee LM, An O, Mayakonda A, Ding LW, Long L, Sun C, Lin LH, Chen L, Wu JY, Wu ZY, Cao Q, ... ... Koeffler HP, et al. Increased Expression of the Long Non-coding RNA LINC01503, Regulated by TP63, in Squamous Cell Carcinoma and Effects on Oncogenic Activities of Cancer Cell Lines. Gastroenterology. PMID 29454790 DOI: 10.1053/J.Gastro.2018.02.018  0.363
2018 Han L, Madan V, Mayakonda A, Dakle P, Teoh WW, Shyamsunder P, Nordin HBM, Cao Z, Sundaresan J, Lei I, Wang Z, Koeffler HP. ARID1A Is Critical for Maintaining Normal Hematopoiesis in Mice Blood. 132: 3833-3833. DOI: 10.1182/Blood-2018-99-117993  0.372
2018 Shyamsunder P, Shanmugasundaram M, Mayakonda A, Teoh WW, Han L, Lim MC, Fullwood M, An O, Yang H, Jizhong S, Hossain MZ, Madan V, Koeffler HP. Identification of a Novel CEBPE Enhancer Essential for Granulocytic Differentiation Blood. 132: 3834-3834. DOI: 10.1182/Blood-2018-99-116091  0.414
2017 Lin DC, Koeffler HP. Genomic lesions drive the metastasis of esophageal squamous cell carcinoma. Journal of Thoracic Disease. 9: 3523-3524. PMID 29268331 DOI: 10.21037/Jtd.2017.09.58  0.311
2017 Hazawa M, Lin DC, Kobayashi A, Jiang YY, Xu L, Dewi FRP, Mohamed MS, Hartono, Nakada M, Meguro-Horike M, Horike SI, Koeffler HP, Wong RW. ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation. Embo Reports. PMID 29217659 DOI: 10.15252/Embr.201744523  0.338
2017 Cao Q, Zhao X, Bai J, Gery S, Sun H, Lin DC, Chen Q, Chen Z, Mack L, Yang H, Deng R, Shi X, Chong LW, Cho H, Xie J, ... ... Koeffler HP, et al. Circadian clock cryptochrome proteins regulate autoimmunity. Proceedings of the National Academy of Sciences of the United States of America. PMID 29109286 DOI: 10.1073/Pnas.1619119114  0.352
2017 Zhang Y, Wang DL, Yan HY, Liao JY, He JH, Hu KS, Deng WX, Wang YJ, Xing HT, Koeffler HP, Yin D. Genome-wide study of ER-regulated lncRNAs shows AP000439.3 may function as a key regulator of cell cycle in breast cancer. Oncology Reports. PMID 29048636 DOI: 10.3892/Or.2017.5975  0.349
2017 Huang M, Chen Y, Yang M, Guo A, Xu Y, Xu L, Koeffler HP. dbCoRC: a database of core transcriptional regulatory circuitries modeled by H3K27ac ChIP-seq signals. Nucleic Acids Research. PMID 28977473 DOI: 10.1093/Nar/Gkx796  0.34
2017 Yuan J, Jiang YY, Mayakonda A, Huang M, Ding LW, Lin H, Yu F, Lu Y, Loh TKS, Chow M, Savage SL, Tyner JW, Lin DC, Koeffler HP. Super-enhancers promote transcriptional dysregulation in nasopharyngeal carcinoma. Cancer Research. PMID 28951465 DOI: 10.1158/0008-5472.Can-17-1143  0.371
2017 Garg M, Kanojia D, Mayakonda A, Ganesan TS, Sadhanandhan B, Suresh S, S S, Nagare RP, Said JW, Doan NB, Ding LW, Baloglu E, Shacham S, Kauffman M, Koeffler HP. Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin. Scientific Reports. 7: 9749. PMID 28852098 DOI: 10.1038/S41598-017-10325-X  0.451
2017 Gugliotta G, Sudo M, Cao Q, Lin DC, Sun H, Takao S, Le Moigne R, Rolfe M, Gery S, Müschen M, Cavo M, Koeffler HP. Valosin-Containing Protein/p97 as a Novel Therapeutic Target in Acute Lymphoblastic Leukemia. Neoplasia (New York, N.Y.). 19: 750-761. PMID 28843399 DOI: 10.1016/J.Neo.2017.08.001  0.385
2017 Lin DC, Wang MR, Koeffler HP. Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients. Gastroenterology. 154: 374-389. PMID 28757263 DOI: 10.1053/J.Gastro.2017.06.066  0.321
2017 Suh HC, Benoukraf T, Shyamsunder P, Yin T, Cao Q, Said J, Lee S, Lim R, Yang H, Salotti J, Johnson PF, Madan V, Koeffler HP. LPS independent activation of the pro-inflammatory receptor Trem1 by C/EBPε in granulocytes. Scientific Reports. 7: 46440. PMID 28440307 DOI: 10.1038/Srep46440  0.34
2017 Xu L, Chen Y, Dutra-Clarke M, Mayakonda A, Hazawa M, Savinoff SE, Doan N, Said JW, Yong WH, Watkins A, Yang H, Ding LW, Jiang YY, Tyner JW, Ching J, ... ... Koeffler HP, et al. BCL6 promotes glioma and serves as a therapeutic target. Proceedings of the National Academy of Sciences of the United States of America. PMID 28356518 DOI: 10.1073/Pnas.1609758114  0.408
2017 Ding LW, Sun QY, Mayakonda A, Tan KT, Chien W, Lin DC, Jiang YY, Xu L, Garg M, Lao ZT, Lill M, Yang H, Yeoh AE, Koeffler HP. Mutational profiling of acute lymphoblastic leukemia with testicular relapse. Journal of Hematology & Oncology. 10: 65. PMID 28253933 DOI: 10.1182/Blood.V128.22.2809.2809  0.333
2017 Xie J, Lin D, Lee DH, Akunowicz J, Hansen M, Miller C, Sanada M, Kato M, Akagi T, Kawamata N, Ogawa S, Koeffler HP. Copy number analysis identifies tumor suppressive lncRNAs in human osteosarcoma. International Journal of Oncology. PMID 28197627 DOI: 10.3892/Ijo.2017.3864  0.563
2017 Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, ... ... Koeffler HP, et al. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 1-5. PMID 28192788 DOI: 10.1038/Nature21076  0.313
2017 Sun Q, Ding L, Tan K, Chien W, Loh X, Xiao J, Mayakonda A, Lin D, Jiang Y, Yang H, Gery S, Koeffler HP. Abstract 806: MGA is a potential tumor suppressor in acute myeloid leukemia Cancer Research. 77: 806-806. DOI: 10.1158/1538-7445.Am2017-806  0.472
2017 Loh XY, Ding LW, Koeffler HP. Abstract 4494: Tumor suppressive role of ZFP36L1 by suppressing HIF1α and Cyclin D1 in bladder and breast cancer Cancer Research. 77: 4494-4494. DOI: 10.1158/1538-7445.Am2017-4494  0.39
2017 Ding L, Sun Q, Tan K, Chien W, Mayakonda A, Lin D, Loh X, Xiao J, Meggendorfer M, Alpermann T, Garg M, Lim S, Madan V, Hattori N, Nagata Y, ... ... Koeffler HP, et al. Abstract 2450: Mutational profiling of MLL-PTD acute myeloid leukemia Cancer Research. 77: 2450-2450. DOI: 10.1158/1538-7445.Am2017-2450  0.333
2016 Ding L, Sun QY, Tan KT, Chien W, Thippeswamy AM, Eng Juh AY, Kawamata N, Nagata Y, Xiao JF, Loh XY, Lin DC, Garg M, Lim SL, Liu LZ, Madan V, ... ... Koeffler HP, et al. Mutational landscape of pediatric acute lymphoblastic leukemia. Cancer Research. PMID 27872090 DOI: 10.1158/0008-5472.CAN-16-1303  0.375
2016 Hazawa M, Lin DC, Handral H, Xu L, Chen Y, Jiang YY, Mayakonda A, Ding LW, Meng X, Sharma A, Samuel S, Movahednia MM, Wong RW, Yang H, Tong C, ... Koeffler HP, et al. ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma. Oncogene. PMID 27819679 DOI: 10.1038/onc.2016.377  0.34
2016 Hao JJ, Lin DC, Dinh HQ, Mayakonda A, Jiang YY, Chang C, Jiang Y, Lu CC, Shi ZZ, Xu X, Zhang Y, Cai Y, Wang JW, Zhan QM, Wei WQ, ... ... Koeffler HP, et al. Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. Nature Genetics. PMID 27749841 DOI: 10.1038/Ng.3683  0.323
2016 Yan H, Hu K, Wu W, Li Y, Tian H, Chu Z, Koeffler HP, Yin D. Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer. Plos One. 11: e0159954. PMID 27532268 DOI: 10.1371/Journal.Pone.0159954  0.372
2016 Jiang YY, Lin DC, Mayakonda A, Hazawa M, Ding LW, Chien WW, Xu L, Chen Y, Xiao JF, Senapedis W, Baloglu E, Kanojia D, Shang L, Xu X, Yang H, ... ... Koeffler HP, et al. Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma. Gut. PMID 27196599 DOI: 10.1136/Gutjnl-2016-311818  0.318
2016 Sun H, Lin DC, Cao Q, Guo X, Marijon H, Zhao Z, Gery S, Xu L, Yang H, Pang B, Lee VK, Lim HJ, Doan N, Said JW, Chu P, ... ... Koeffler HP, et al. CRM1 inhibition promotes cytotoxicity in Ewing sarcoma cells by repressing EWS-FLI1-dependent IGF-1 signaling. Cancer Research. PMID 26956669 DOI: 10.1158/0008-5472.Can-15-1572  0.403
2016 Cao Q, Gearhart MD, Gery S, Shojaee S, Yang H, Sun H, Lin DC, Bai JW, Mead M, Zhao Z, Chen Q, Chien WW, Alkan S, Alpermann T, Haferlach T, ... ... Koeffler HP, et al. BCOR regulates myeloid cell proliferation and differentiation. Leukemia. PMID 26847029 DOI: 10.1038/Leu.2016.2  0.314
2016 Togami K, Madan V, Li J, Villani A, Sarkizova S, Ghandi M, Buczkowski K, Li Y, Biichle S, Angelot-Delettre F, Seiler M, Buonamici S, Taylor J, Abdel-Wahab O, Hammerman PS, ... ... Koeffler HP, et al. Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) Harbors Frequent Splicesosome Mutations That Cause Aberrant RNA Splicing Affecting Genes Critical in pDC Differentiation and Function Blood. 128: 738-738. DOI: 10.1182/Blood.V128.22.738.738  0.348
2016 Madan V, Han L, Hattori N, Mayakonda A, Sun Q, Ding L, Binte Mohd Nordin H, Lim SL, Teoh WW, Shyamsunder P, Sundaresan J, Doan NB, Sanada M, Sato-Otsubo A, Liu L, ... ... Koeffler HP, et al. ASXL2 Is Recurrently Mutated in t(8;21) AML and Regulates Hematopoietic Development Blood. 128: 1051-1051. DOI: 10.1182/Blood.V128.22.1051.1051  0.386
2015 Kanojia D, Nagata Y, Garg M, Lee DH, Sato A, Yoshida K, Sato Y, Sanada M, M T A, Bartenhagen C, Klein HU, Doan NB, Said JW, Mohith S, Gunasekar S, ... ... Koeffler HP, et al. Genomic landscape of liposarcoma. Oncotarget. PMID 26643872 DOI: 10.18632/Oncotarget.6464  0.577
2015 Sakamoto S, Kawabata H, Masuda T, Uchiyama T, Mizumoto C, Ohmori K, Koeffler HP, Kadowaki N, Takaori-Kondo A. H-Ferritin Is Preferentially Incorporated by Human Erythroid Cells through Transferrin Receptor 1 in a Threshold-Dependent Manner. Plos One. 10: e0139915. PMID 26441243 DOI: 10.1371/Journal.Pone.0139915  0.321
2015 Garg M, Nagata Y, Kanojia D, M T A, Yoshida K, Keloth SH, Jiang ZZ, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ding LW, Alpermann T, Sun QY, ... ... Koeffler HP, et al. Profiling of somatic mutations of acute myeloid leukemia, FLT3-ITD subgroup at diagnosis and relapse. Blood. PMID 26438511 DOI: 10.1182/Blood-2015-05-646240  0.35
2015 Ashwini N, Garg M, Mohan CD, Fuchs JE, Rangappa S, Anusha S, Swaroop TR, Rakesh KS, Kanojia D, Madan V, Bender A, Koeffler HP, Basappa, Rangappa KS. Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation. Bioorganic & Medicinal Chemistry. 23: 6157-65. PMID 26299825 DOI: 10.1016/J.Bmc.2015.07.069  0.384
2015 Guan DX, Shi J, Zhang Y, Zhao JS, Long LY, Chen TW, Zhang EB, Feng YY, Bao WD, Deng YZ, Qiu L, Zhang XL, Koeffler HP, Li JJ, Cheng S, et al. Sorafenib enriches EpCAM positive tumor initiating cells and exacerbates a subtype of hepatocellular carcinoma through TSC2-AKT cascade. Hepatology (Baltimore, Md.). PMID 26257239 DOI: 10.1002/Hep.28117  0.37
2015 Lee DH, Forscher C, Di Vizio D, Koeffler HP. Induction of p53-independent apoptosis by ectopic expression of HOXA5 in human liposarcomas. Scientific Reports. 5: 12580. PMID 26219418 DOI: 10.1038/Srep12580  0.537
2015 Shojaee S, Caeser R, Buchner M, Park E, Swaminathan S, Hurtz C, Geng H, Chan LN, Klemm L, Hofmann WK, Qiu YH, Zhang N, Coombes KR, Paietta E, Molkentin J, ... Koeffler HP, et al. Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. Cancer Cell. 28: 114-28. PMID 26073130 DOI: 10.1016/J.Ccell.2015.05.008  0.377
2015 Wada T, Akagi T, Muraoka M, Toma T, Kaji K, Agematsu K, Koeffler HP, Yokota T, Yachie A. A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency. Journal of Immunology (Baltimore, Md. : 1950). 195: 80-6. PMID 26019275 DOI: 10.4049/Jimmunol.1402222  0.339
2015 Huang D, Nagata Y, Grossmann V, Radivoyevitch T, Okuno Y, Nagae G, Hosono N, Schnittger S, Sanada M, Przychodzen B, Kon A, Polprasert C, Shen W, Clemente MJ, Phillips JG, ... ... Koeffler HP, et al. BRCC3 mutations in myeloid neoplasms. Haematologica. PMID 26001790 DOI: 10.3324/Haematol.2014.111989  0.327
2015 Lin DC, Xu L, Chen Y, Yan H, Hazawa M, Doan N, Said JW, Ding LW, Liu LZ, Yang H, Yu S, Kahn M, Yin D, Koeffler HP. Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma. Cancer Research. 75: 1815-27. PMID 25877876 DOI: 10.1158/0008-5472.Can-14-1433  0.379
2015 Chien W, Sun QY, Lee KL, Ding LW, Wuensche P, Torres-Fernandez LA, Tan SZ, Tokatly I, Zaiden N, Poellinger L, Mori S, Yang H, Tyner JW, Koeffler HP. Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer. Molecular Oncology. 9: 889-905. PMID 25637283 DOI: 10.1016/J.Molonc.2015.01.002  0.394
2015 Madan V, Kanojia D, Li J, Okamoto R, Sato-Otsubo A, Kohlmann A, Sanada M, Grossmann V, Sundaresan J, Shiraishi Y, Miyano S, Thol F, Ganser A, Yang H, Haferlach T, ... ... Koeffler HP, et al. Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome. Nature Communications. 6: 6042. PMID 25586593 DOI: 10.1038/Ncomms7042  0.305
2015 Sudo M, Mori S, Madan V, Yang H, Leong G, Koeffler HP. Short-hairpin RNA library: identification of therapeutic partners for gefitinib-resistant non-small cell lung cancer. Oncotarget. 6: 814-24. PMID 25528770 DOI: 10.18632/Oncotarget.2891  0.387
2015 Nowak D, Liem NL, Mossner M, Klaumünzer M, Papa RA, Nowak V, Jann JC, Akagi T, Kawamata N, Okamoto R, Thoennissen NH, Kato M, Sanada M, Hofmann WK, Ogawa S, ... ... Koeffler HP, et al. Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance. Experimental Hematology. 43: 32-43.e1-35. PMID 25450514 DOI: 10.1016/J.Exphem.2014.09.007  0.335
2015 Sun QY, Ding LW, Xiao JF, Chien W, Lim SL, Hattori N, Goodglick L, Chia D, Mah V, Alavi M, Kim SR, Doan NB, Said JW, Loh XY, Xu L, ... ... Koeffler HP, et al. SETDB1 accelerates tumourigenesis by regulating the WNT signalling pathway. The Journal of Pathology. 235: 559-70. PMID 25404354 DOI: 10.1002/Path.4482  0.388
2015 Garg M, Okamoto R, Nagata Y, Kanojia D, Venkatesan S, M T A, Braunstein GD, Said JW, Doan NB, Ho Q, Akagi T, Gery S, Liu LZ, Tan KT, Chng WJ, ... ... Koeffler HP, et al. Establishment and characterization of novel human primary and metastatic anaplastic thyroid cancer cell lines and their genomic evolution over a year as a primagraft. The Journal of Clinical Endocrinology and Metabolism. 100: 725-35. PMID 25365311 DOI: 10.1210/Jc.2014-2359  0.331
2015 Lee DH, Qi J, Bradner JE, Said JW, Doan NB, Forscher C, Yang H, Koeffler HP. Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma. International Journal of Cancer. Journal International Du Cancer. 136: 2055-64. PMID 25307878 DOI: 10.1002/Ijc.29269  0.612
2015 Dhawan P, Wei R, Sun C, Gombart AF, Koeffler HP, Diamond G, Christakos S. C/EBPα and the Vitamin D Receptor Cooperate in the Regulation of Cathelicidin in Lung Epithelial Cells. Journal of Cellular Physiology. 230: 464-72. PMID 25078430 DOI: 10.1002/Jcp.24729  0.348
2015 Ding LW, Sun QY, Lin DC, Chien W, Hattori N, Dong XM, Gery S, Garg M, Doan NB, Said JW, Xiao JF, Yang H, Liu LZ, Meng X, Huang RY, ... ... Koeffler HP, et al. LNK (SH2B3): paradoxical effects in ovarian cancer. Oncogene. 34: 1463-74. PMID 24704825 DOI: 10.1038/onc.2014.34  0.321
2015 Chan LN, Chen Z, Braas D, Geng H, Hurtz C, Shojaee S, Cazzaniga V, Ng C, Ernst T, Hochhaus A, Kornblau SM, Cazzaniga G, Liu G, Milne T, Koeffler HP, et al. B-Lymphoid Transcription Factors Restrict Glycolytic Energy Supply for Oncogenic Signaling Blood. 126: 1255-1255. DOI: 10.1182/Blood.V126.23.1255.1255  0.354
2015 Cao Q, Zhao X, Gery S, Chen Z, Deng R, Sun H, Lin D, Zhao Z, Said JW, Li Q, Muschen M, Evans RM, Koeffler HP. Circadian Clock Protein CRY Controls B-Cell Intrinsic Tolerance Blood. 126: 1029-1029. DOI: 10.1182/Blood.V126.23.1029.1029  0.325
2015 Kanojia D, Garg M, Nagata Y, Lee DH, Klein H, Bartenhagen C, T AM, Doan NB, Said JW, Yang H, Forscher C, Dugas M, Ogawa S, Koeffler HP. Abstract A2-20: Integrative study of genomic alterations in liposarcoma Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-A2-20  0.57
2015 Sun Q, Ding L, Xiao J, Goodglick L, Chia D, Mah V, Alavi M, Doan N, Said JW, Yang H, Koeffler HP. Abstract 2868: SETDB1 accelerates non-small cell lung cancer (NSCLC) tumorigenesis through WNT signalling pathway Cancer Research. 75: 2868-2868. DOI: 10.1158/1538-7445.Am2015-2868  0.418
2015 Chien W, Xiao J, Ding L, Muzakar MIB, Sun Q, Gery S, Senapedis W, Shacham S, Baloglu E, Koeffler HP. Abstract 138: Novel PAK4 allosteric modulators (PAMs) provide potential therapeutic options in human gastric cancer Cancer Research. 75: 138-138. DOI: 10.1158/1538-7445.Am2015-138  0.348
2014 Keerthy HK, Garg M, Mohan CD, Madan V, Kanojia D, Shobith R, Nanjundaswamy S, Mason DJ, Bender A, Basappa, Rangappa KS, Koeffler HP. Synthesis and characterization of novel 2-amino-chromene-nitriles that target Bcl-2 in acute myeloid leukemia cell lines. Plos One. 9: e107118. PMID 25268519 DOI: 10.1371/Journal.Pone.0107118  0.328
2014 Sarkissyan S, Sarkissyan M, Wu Y, Cardenas J, Koeffler HP, Vadgama JV. IGF-1 regulates Cyr61 induced breast cancer cell proliferation and invasion. Plos One. 9: e103534. PMID 25062088 DOI: 10.1371/Journal.Pone.0103534  0.321
2014 Zheng Y, Gery S, Sun H, Shacham S, Kauffman M, Koeffler HP. KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma. Cancer Chemotherapy and Pharmacology. 74: 487-95. PMID 25030088 DOI: 10.1007/S00280-014-2495-8  0.321
2014 Lin DC, Meng X, Hazawa M, Nagata Y, Varela AM, Xu L, Sato Y, Liu LZ, Ding LW, Sharma A, Goh BC, Lee SC, Petersson BF, Yu FG, Macary P, ... ... Koeffler HP, et al. The genomic landscape of nasopharyngeal carcinoma. Nature Genetics. 46: 866-71. PMID 24952746 DOI: 10.1038/Ng.3006  0.321
2014 Lin DC, Hao JJ, Nagata Y, Xu L, Shang L, Meng X, Sato Y, Okuno Y, Varela AM, Ding LW, Garg M, Liu LZ, Yang H, Yin D, Shi ZZ, ... ... Koeffler HP, et al. Genomic and molecular characterization of esophageal squamous cell carcinoma. Nature Genetics. 46: 467-73. PMID 24686850 DOI: 10.1038/Ng.2935  0.393
2014 Xu L, Lin DC, Yin D, Koeffler HP. An emerging role of PARK2 in cancer. Journal of Molecular Medicine (Berlin, Germany). 92: 31-42. PMID 24297497 DOI: 10.1007/S00109-013-1107-0  0.34
2014 Lin L, Gaut D, Hu K, Yan H, Yin D, Koeffler HP. Dual targeting of glioblastoma multiforme with a proteasome inhibitor (Velcade) and a phosphatidylinositol 3-kinase inhibitor (ZSTK474). International Journal of Oncology. 44: 557-62. PMID 24297065 DOI: 10.3892/Ijo.2013.2205  0.372
2014 Haferlach T, Nagata Y, Grossmann V, Okuno Y, Bacher U, Nagae G, Schnittger S, Sanada M, Kon A, Alpermann T, Yoshida K, Roller A, Nadarajah N, Shiraishi Y, Shiozawa Y, ... ... Koeffler HP, et al. Landscape of genetic lesions in 944 patients with myelodysplastic syndromes. Leukemia. 28: 241-7. PMID 24220272 DOI: 10.1182/Blood.V122.21.521.521  0.324
2014 Garg M, Kanojia D, Okamoto R, Jain S, Madan V, Chien W, Sampath A, Ding LW, Xuan M, Said JW, Doan NB, Liu LZ, Yang H, Gery S, Braunstein GD, ... Koeffler HP, et al. Laminin-5γ-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and is associated with tumor progression, migration, and invasion by modulating signaling of EGFR. The Journal of Clinical Endocrinology and Metabolism. 99: E62-72. PMID 24170107 DOI: 10.1210/Jc.2013-2994  0.302
2014 Okamoto R, Gery S, Kuwayama Y, Borregaard N, Ho Q, Alvarez R, Akagi T, Liu GY, Uskokovic MR, Koeffler HP. Novel Gemini vitamin D3 analogs: large structure/function analysis and ability to induce antimicrobial peptide. International Journal of Cancer. 134: 207-17. PMID 23775785 DOI: 10.1002/Ijc.28328  0.343
2014 Chien W, Lee DH, Zheng Y, Wuensche P, Alvarez R, Wen DL, Aribi AM, Thean SM, Doan NB, Said JW, Koeffler HP. Growth inhibition of pancreatic cancer cells by histone deacetylase inhibitor belinostat through suppression of multiple pathways including HIF, NFkB, and mTOR signaling in vitro and in vivo. Molecular Carcinogenesis. 53: 722-35. PMID 23475695 DOI: 10.1002/Mc.22024  0.592
2014 Madan V, Kanojia D, Jia L, Okamoto R, Sato-Otsubo A, Kohlmann A, Sanada M, Grossmann V, Sundaresan J, Shiraishi Y, Miyano S, Thol F, Ganser A, Yang H, Haferlach T, ... ... Koeffler HP, et al. ZRSR2 Mutations Cause Dysregulated RNA Splicing in MDS Blood. 124: 4609-4609. DOI: 10.1182/Blood.V124.21.4609.4609  0.346
2014 Akagi T, Wada T, Muraoka M, Toma T, Kaji K, Agematsu K, Koeffler HP, Yokota T, Yachie A. A Novel 2 Amino Acids Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency (SGD) Blood. 124: 4101-4101. DOI: 10.1182/Blood.V124.21.4101.4101  0.388
2014 Garg M, Kanojia D, Okamoto R, Madan V, Chien W, Sampath A, Ding L, Xuan M, Said JW, Doan N, Liu L, Yang H, Gery S, Braunstein GD, Koeffler HP. Abstract 5570: Laminin-5 gamma-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and is associated with tumor progression, migration and invasion by modulating signaling of EGFR Cancer Research. 74: 5570-5570. DOI: 10.1158/1538-7445.Am2014-5570  0.418
2014 Marijon H, Sun H, Gramont Ad, Gery S, Koeffler HP. Abstract 5542: Synergistic inhibition of growth of triple-negative breast cancer cells by co-targeting PARP and HDAC Cancer Research. 74: 5542-5542. DOI: 10.1158/1538-7445.Am2014-5542  0.415
2014 Sun H, Masouleh BK, Gery S, Cao Q, Alkan S, Ikezoe T, Akiba C, Paquette R, Chien W, Müller-Tidow C, Jing Y, Masouleh K, Müschen M, Koeffler HP. Abstract 510: Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia Cancer Research. 74: 510-510. DOI: 10.1158/1538-7445.Am2014-510  0.424
2014 Lee DHT, Qi J, Bradner J, Said J, Doan N, Forscher C, Koeffler HP. Abstract 1689: Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma Cancer Research. 74: 1689-1689. DOI: 10.1158/1538-7445.Am2014-1689  0.429
2014 Meng X, Lin D, Nagata Y, Sato Y, Goh BC, Lee SC, Yu FG, Ogawa S, Loh KS, Koeffler HP. O1-18-3Exome Sequencing And Snp Array Reveal Epigenome Modifier Defects In Nasopharyngeal Carcinoma Annals of Oncology. 25. DOI: 10.1093/Annonc/Mdu435.42  0.399
2013 Kon A, Shih LY, Minamino M, Sanada M, Shiraishi Y, Nagata Y, Yoshida K, Okuno Y, Bando M, Nakato R, Ishikawa S, Sato-Otsubo A, Nagae G, Nishimoto A, Haferlach C, ... ... Koeffler HP, et al. Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nature Genetics. 45: 1232-7. PMID 23955599 DOI: 10.1038/Ng.2731  0.38
2013 Swaminathan S, Huang C, Geng H, Chen Z, Harvey R, Kang H, Ng C, Titz B, Hurtz C, Sadiyah MF, Nowak D, Thoennissen GB, Rand V, Graeber TG, Koeffler HP, et al. BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint. Nature Medicine. 19: 1014-22. PMID 23852341 DOI: 10.1038/Nm.3247  0.403
2013 Chan D, Zheng Y, Tyner JW, Chng WJ, Chien WW, Gery S, Leong G, Braunstein GD, Koeffler HP. Belinostat and panobinostat (HDACI): in vitro and in vivo studies in thyroid cancer. Journal of Cancer Research and Clinical Oncology. 139: 1507-14. PMID 23824064 DOI: 10.1007/S00432-013-1465-6  0.324
2013 Kawamata N, Moreilhon C, Saitoh T, Karasawa M, Bernstein BK, Sato-Otsubo A, Ogawa S, Raynaud S, Koeffler HP. Genetic differences between Asian and Caucasian chronic lymphocytic leukemia. International Journal of Oncology. 43: 561-5. PMID 23708256 DOI: 10.3892/Ijo.2013.1966  0.303
2013 Lee DH, Amanat S, Goff C, Weiss LM, Said JW, Doan NB, Sato-Otsubo A, Ogawa S, Forscher C, Koeffler HP. Overexpression of miR-26a-2 in human liposarcoma is correlated with poor patient survival. Oncogenesis. 2: e47. PMID 23689287 DOI: 10.1038/oncsis.2013.10  0.456
2013 Koren-Michowitz M, Gery S, Tabayashi T, Lin D, Alvarez R, Nagler A, Koeffler HP. SH2B3 (LNK) mutations from myeloproliferative neoplasms patients have mild loss of function against wild type JAK2 and JAK2 V617F. British Journal of Haematology. 161: 811-20. PMID 23590807 DOI: 10.1111/Bjh.12327  0.321
2013 Lin DC, Xu L, Ding LW, Sharma A, Liu LZ, Yang H, Tan P, Vadgama J, Karlan BY, Lester J, Urban N, Schummer M, Doan N, Said JW, Sun H, ... ... Koeffler HP, et al. Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers. Proceedings of the National Academy of Sciences of the United States of America. 110: 6109-14. PMID 23536305 DOI: 10.1073/Pnas.1218206110  0.452
2013 Sudo M, Chin TM, Mori S, Doan NB, Said JW, Akashi M, Koeffler HP. Inhibiting proliferation of gefitinib-resistant, non-small cell lung cancer. Cancer Chemotherapy and Pharmacology. 71: 1325-34. PMID 23515752 DOI: 10.1007/S00280-013-2132-Y  0.321
2013 Aribi A, Gery S, Lee DH, Thoennissen NH, Thoennissen GB, Alvarez R, Ho Q, Lee K, Doan NB, Chan KT, Toh M, Said JW, Koeffler HP. The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer. International Journal of Cancer. Journal International Du Cancer. 132: 2730-7. PMID 23165325 DOI: 10.1002/Ijc.27950  0.538
2013 Masouleh BK, Geng H, Hurtz C, Huang C, Chan LN, Swaminathan S, Sun H, Koeffler HP, Melnick A, Paietta E, Glimcher LH, Muschen M. The Plasma Cell Transcription Factor XBP1 is Required To Mitigate The Unfolded Protein Response In Ph+ ALL Blood. 122: 836-836. DOI: 10.1182/Blood.V122.21.836.836  0.413
2013 Kon A, Shih L, Minamino M, Sanada M, Shiraishi Y, Nagata Y, Yoshida K, Okuno Y, Bando M, Ishikawa S, Sato-Otsubo A, Nagae G, Nishimoto A, Haferlach C, Nowak D, ... ... Koeffler HP, et al. Abstract 4602: Recurrent pathway mutations of multiple components of cohesin complex in myeloid neoplasms. Cancer Research. 73: 4602-4602. DOI: 10.1158/1538-7445.Am2013-4602  0.351
2013 Chien W, Sun Q, Lim SL, Varela ADSM, Sun H, Gery S, Koeffler HP. Abstract 4042: Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells. Cancer Research. 73: 4042-4042. DOI: 10.1158/1538-7445.Am2013-4042  0.409
2013 Sun H, Masouleh BK, Gery S, Cao Q, Yin T, Alkan S, Ikezoe T, Akiba C, Paquette R, Chien W, Müller-Tidow C, Yang J, Agelopoulos K, Markus M, Koeffler HP. Abstract 2030: Inhibition of IRE1α-XBP1 pathway is a promising therapeutic application in acute myeloid leukemia. Cancer Research. 73: 2030-2030. DOI: 10.1158/1538-7445.Am2013-2030  0.43
2013 Chien W, Lee KL, Sun Q, Wuensche P, Sudo M, Poellinger L, Tyner JW, Yang H, Koeffler HP. Abstract 1291: Identification of penfluridol as potential treatment for pancreatic cancer cells. Cancer Research. 73: 1291-1291. DOI: 10.1158/1538-7445.Am2013-1291  0.377
2012 Lin DC, Yin T, Koren-Michowitz M, Ding LW, Gueller S, Gery S, Tabayashi T, Bergholz U, Kazi JU, Rönnstrand L, Stocking C, Koeffler HP. Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3. Blood. 120: 3310-7. PMID 22942183 DOI: 10.1182/Blood-2011-10-388611  0.399
2012 Yin D, Yang WG, Weissberg J, Goff CB, Chen W, Kuwayama Y, Leiter A, Xing H, Meixel A, Gaut D, Kirkbir F, Sawcer D, Vernier PT, Said JW, Gundersen MA, ... Koeffler HP, et al. Cutaneous papilloma and squamous cell carcinoma therapy utilizing nanosecond pulsed electric fields (nsPEF). Plos One. 7: e43891. PMID 22937117 DOI: 10.1371/Journal.Pone.0043891  0.335
2012 Kyme P, Thoennissen NH, Tseng CW, Thoennissen GB, Wolf AJ, Shimada K, Krug UO, Lee K, Müller-Tidow C, Berdel WE, Hardy WD, Gombart AF, Koeffler HP, Liu GY. C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice. The Journal of Clinical Investigation. 122: 3316-29. PMID 22922257 DOI: 10.1172/Jci62070  0.313
2012 Uehara E, Takeuchi S, Yang Y, Fukumoto T, Matsuhashi Y, Tamura T, Matsushita M, Nagai M, Koeffler HP, Tasaka T. Aberrant methylation in promoter-associated CpG islands of multiple genes in chronic myelogenous leukemia blast crisis. Oncology Letters. 3: 190-192. PMID 22740879 DOI: 10.3892/Ol.2011.419  0.329
2012 Tong Y, Zheng Y, Zhou J, Oyesiku NM, Koeffler HP, Melmed S. Genomic characterization of human and rat prolactinomas. Endocrinology. 153: 3679-91. PMID 22635680 DOI: 10.1210/En.2012-1056  0.305
2012 Shi S, Deng YZ, Zhao JS, Ji XD, Shi J, Feng YX, Li G, Li JJ, Zhu D, Koeffler HP, Zhao Y, Xie D. RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway. The Journal of Biological Chemistry. 287: 7845-58. PMID 22262830 DOI: 10.1074/Jbc.M111.315416  0.372
2012 Thoennissen NH, Thoennissen GB, Abbassi S, Nabavi-Nouis S, Sauer T, Doan NB, Gery S, Müller-Tidow C, Said JW, Koeffler HP. Transcription factor CCAAT/enhancer-binding protein alpha and critical circadian clock downstream target gene PER2 are highly deregulated in diffuse large B-cell lymphoma. Leukemia & Lymphoma. 53: 1577-85. PMID 22260161 DOI: 10.3109/10428194.2012.658792  0.43
2012 Okamoto R, Delansorne R, Wakimoto N, Doan NB, Akagi T, Shen M, Ho QH, Said JW, Koeffler HP. Inecalcitol, an analog of 1α,25(OH)(2) D(3) , induces growth arrest of androgen-dependent prostate cancer cells. International Journal of Cancer. 130: 2464-73. PMID 21732345 DOI: 10.1002/Ijc.26279  0.333
2012 Kon A, Shih L, Minamino M, Sanada M, Shiraishi Y, Nagata Y, Yoshida K, Okuno Y, Bando M, Ishikawa S, Sato-Otsubo A, Nagae G, Haferlach C, Nowak D, Sato Y, ... ... Koeffler HP, et al. Recurrent Mutations of Multiple Components of Cohesin Complex in Myeloid Neoplasms Blood. 120: 782-782. DOI: 10.1182/Blood.V120.21.782.782  0.358
2012 Cao Q, Gery S, Shojaee S, Gearhart M, Bardwell V, Muschen M, Koeffler HP. BCOR Is Involved in Myeloid Cell Growth Control by Regulating Hox Genes Blood. 120: 3445-3445. DOI: 10.1182/Blood.V120.21.3445.3445  0.446
2012 Shojaee S, Buchner M, Swaminathan S, Geng H, Chan L, Bothe M, Chen Z, Melnick A, Molkentin J, Martin G, Koeffler HP, Muschen M. Negative Feedback Signaling Enables Leukemic Transformation by Oncogenic Tyrosine Kinases Blood. 120: 1352-1352. DOI: 10.1182/Blood.V120.21.1352.1352  0.384
2012 Nagata Y, Sanada M, Yoshida K, Kon A, Sato Y, Sato A, Shiraishi Y, Mori H, Miyano S, Shih L, Miyawaki S, Chiba S, Koeffler HP, Ogawa S. Abstract 5122: Integral view of copy number alteration and commonly targeted genes in MDS found a new aspect of correlation and interrelationship with mutated components of the RNA splicing machinery Cancer Research. 72: 5122-5122. DOI: 10.1158/1538-7445.Am2012-5122  0.346
2012 Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, ... ... Koeffler HP, et al. Abstract 5119: Frequent splicing pathway mutations and aberrant RNA splicing in myelodysplasia Cancer Research. 72: 5119-5119. DOI: 10.1158/1538-7445.Am2012-5119  0.332
2012 Kon A, Sanada M, Yoshida K, Shiraishi Y, Nagata Y, Sato Y, Sato-Otsubo A, Nagasaki M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Miyawaki S, Koeffler HP, Shih L, et al. Abstract 5117: Mutations of cohesin genes in myeloid malignancy Cancer Research. 72: 5117-5117. DOI: 10.1158/1538-7445.Am2012-5117  0.368
2012 Yin D, Gaut D, Ho QH, Koeffler HP. Abstract 2801: Dual Targeting Glioblastoma Multiforme (GBM) with a Phosphatidylinositol 3-kinase inhibitor (ZSTK474) and a Proteasome Inhibitor (Velcade) Cancer Research. 72: 2801-2801. DOI: 10.1158/1538-7445.Am2012-2801  0.404
2011 Tong Y, Zhou J, Mizutani J, Fukuoka H, Ren SG, Gutierrez-Hartmann A, Koeffler HP, Melmed S. CEBPD suppresses prolactin expression and prolactinoma cell proliferation. Molecular Endocrinology (Baltimore, Md.). 25: 1880-91. PMID 21980073 DOI: 10.1210/Me.2011-1075  0.403
2011 Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, ... ... Koeffler HP, et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature. 478: 64-9. PMID 21909114 DOI: 10.1038/nature10496  0.335
2011 Zhao JS, Li WJ, Ge D, Zhang PJ, Li JJ, Lu CL, Ji XD, Guan DX, Gao H, Xu LY, Li EM, Soukiasian H, Koeffler HP, Wang XF, Xie D. Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44. Plos One. 6: e21419. PMID 21731740 DOI: 10.1371/Journal.Pone.0021419  0.349
2011 Duy C, Hurtz C, Shojaee S, Cerchietti L, Geng H, Swaminathan S, Klemm L, Kweon SM, Nahar R, Braig M, Park E, Kim YM, Hofmann WK, Herzog S, Jumaa H, ... Koeffler HP, et al. BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature. 473: 384-8. PMID 21593872 DOI: 10.1038/Nature09883  0.335
2011 Chien W, O'Kelly J, Lu D, Leiter A, Sohn J, Yin D, Karlan B, Vadgama J, Lyons KM, Koeffler HP. Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis. International Journal of Oncology. 38: 1741-7. PMID 21455569 DOI: 10.3892/Ijo.2011.985  0.355
2011 Lee DH, Thoennissen NH, Goff C, Iwanski GB, Forscher C, Doan NB, Said JW, Koeffler HP. Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma. Cancer Letters. 306: 161-70. PMID 21440986 DOI: 10.1016/J.Canlet.2011.03.001  0.544
2011 Gueller S, Hehn S, Nowak V, Gery S, Serve H, Brandts CH, Koeffler HP. Adaptor protein Lnk binds to PDGF receptor and inhibits PDGF-dependent signaling. Experimental Hematology. 39: 591-600. PMID 21310211 DOI: 10.1016/J.Exphem.2011.02.001  0.336
2011 Ji XD, Li G, Feng YX, Zhao JS, Li JJ, Sun ZJ, Shi S, Deng YZ, Xu JF, Zhu YQ, Koeffler HP, Tong XJ, Xie D. EphB3 is overexpressed in non-small-cell lung cancer and promotes tumor metastasis by enhancing cell survival and migration. Cancer Research. 71: 1156-66. PMID 21266352 DOI: 10.1158/0008-5472.Can-10-0717  0.418
2011 Ikezoe T, Kojima S, Furihata M, Yang J, Nishioka C, Takeuchi A, Isaka M, Koeffler HP, Yokoyama A. Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia. International Journal of Cancer. 129: 2512-21. PMID 21207414 DOI: 10.1002/Ijc.25910  0.336
2011 Ikezoe T, Yang J, Nishioka C, Kojima S, Takeuchi A, Koeffler HP, Yokoyama A. Inhibition of signal transducer and activator of transcription 5 by the inhibitor of janus kinases stimulates dormant human leukemia CD34+ /CD38- cells and sensitizes them to antileukemia agents. International Journal of Cancer. 128: 2317-2325. PMID 21128225 DOI: 10.1002/Ijc.25806  0.324
2011 Schnittger S, Meggendorfer M, Kohlmann A, Grossmann V, Yoshida K, Ogawa S, Koeffler HP, Kern W, Haferlach C, Haferlach T. SRSF2 is Mutated in 47.2% (77/163) of Chronic Myelomonocytic Leukemia (CMML) and Prognostically Favorable in Cases with Concomitant RUNX1 mutations Blood. 118: 274-274. DOI: 10.1182/Blood.V118.21.274.274  0.31
2011 Nagata Y, Sanada M, Kon A, Yoshida K, Shiraishi Y, Sato-Otsubo A, Mori H, Ishiyama K, Sakata-Yanagimoto M, Obara N, Nagasaki M, Miyawaki S, Chiba S, Miyano S, Yung SL, ... Koeffler HP, et al. Mutational Spectrum Analysis of Interesting Correlation and Interrelationship Between RNA Splicing Pathway and Commonly Targeted Genes in Myelodysplastic Syndrome Blood. 118: 273-273. DOI: 10.1182/Blood.V118.21.273.273  0.305
2011 Kon A, Sanada M, Yoshida K, Nagata Y, Shiraishi Y, Sato Y, Sato-Otsubo A, Yamamoto R, Nagasaki M, Suzuki Y, Yamaguchi T, Otsu M, Sugano S, Chiba S, Koeffler HP, et al. Functional Analysis of SRSF2 Mutations in Myelodysplastic Syndromes and Related Disorders Blood. 118: 1706-1706. DOI: 10.1182/Blood.V118.21.1706.1706  0.416
2011 Lee DHT, Goff C, Cutter S, Amanat S, Doan N, Said J, Forscher C, Koeffler HP. Abstract LB-345: Amplification of miR-26a-2 in human liposarcoma is correlated with poor patient survival Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-345  0.311
2011 Nagata Y, Sanada M, Yoshida K, Sato Y, Nakaya T, Matsubara A, Ishiyama K, Miyawaki S, Obara N, Chiba S, Shih L, Koeffler HP, Ogawa S. Abstract 4849: Profiling of multiple gene mutations in myelodysplastic syndromes using high-throughput resequenceing combined with barcode labeling Cancer Research. 71: 4849-4849. DOI: 10.1158/1538-7445.Am2011-4849  0.344
2011 Lee DHT, Thoennissen N, Goff C, Iwanski G, Doan N, Said J, Koeffler HP. Abstract 3546: Cucurbitacin B as a direct mTOR inhibitor synergizes with methotrexate for treatment of human osteosarcoma Cancer Research. 71: 3546-3546. DOI: 10.1158/1538-7445.Am2011-3546  0.362
2011 Sarkissyan S, Sarkissyan M, Wu Y, Koeffler HP, Vadgama JV. Abstract 2348: Cyr61 and FOXOA1 are inversely regulated in IGF-1 mediated breast cancer cells Cancer Research. 71: 2348-2348. DOI: 10.1158/1538-7445.Am2011-2348  0.433
2010 Koeffler HP. Is there a role for differentiating therapy in non-APL AML? Best Practice & Research. Clinical Haematology. 23: 503-8. PMID 21130414 DOI: 10.1016/J.Beha.2010.09.014  0.359
2010 Akagi T, Thoennissen NH, George A, Crooks G, Song JH, Okamoto R, Nowak D, Gombart AF, Koeffler HP. In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response. Plos One. 5: e15419. PMID 21072215 DOI: 10.1371/Journal.Pone.0015419  0.315
2010 Chen W, Leiter A, Yin D, Meiring M, Louw VJ, Koeffler HP. Cucurbitacin B inhibits growth, arrests the cell cycle, and potentiates antiproliferative efficacy of cisplatin in cutaneous squamous cell carcinoma cell lines. International Journal of Oncology. 37: 737-43. PMID 20664943 DOI: 10.3892/Ijo_00000723  0.346
2010 Iwanski GB, Lee DH, En-Gal S, Doan NB, Castor B, Vogt M, Toh M, Bokemeyer C, Said JW, Thoennissen NH, Koeffler HP. Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer. British Journal of Pharmacology. 160: 998-1007. PMID 20590594 DOI: 10.1111/J.1476-5381.2010.00741.X  0.551
2010 Ogawa S, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP, Sanada M. Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 3825-31. PMID 20547695 DOI: 10.1158/1078-0432.Ccr-09-2341  0.348
2010 Lilljebjörn H, Soneson C, Andersson A, Heldrup J, Behrendtz M, Kawamata N, Ogawa S, Koeffler HP, Mitelman F, Johansson B, Fontes M, Fioretos T. The correlation pattern of acquired copy number changes in 164 ETV6/RUNX1-positive childhood acute lymphoblastic leukemias. Human Molecular Genetics. 19: 3150-8. PMID 20513752 DOI: 10.1093/Hmg/Ddq224  0.316
2010 Duy C, Yu JJ, Nahar R, Swaminathan S, Kweon SM, Polo JM, Valls E, Klemm L, Shojaee S, Cerchietti L, Schuh W, Jäck HM, Hurtz C, Ramezani-Rad P, Herzog S, ... ... Koeffler HP, et al. BCL6 is critical for the development of a diverse primary B cell repertoire. The Journal of Experimental Medicine. 207: 1209-21. PMID 20498019 DOI: 10.1084/Jem.20091299  0.356
2010 Yang J, Ikezoe T, Nishioka C, Ni L, Koeffler HP, Yokoyama A. Inhibition of mTORC1 by RAD001 (everolimus) potentiates the effects of 1,25-dihydroxyvitamin D(3) to induce growth arrest and differentiation of AML cells in vitro and in vivo. Experimental Hematology. 38: 666-76. PMID 20382200 DOI: 10.1016/J.Exphem.2010.03.020  0.366
2010 Yin D, Chen W, O'Kelly J, Lu D, Ham M, Doan NB, Xie D, Wang C, Vadgama J, Said JW, Black KL, Koeffler HP. Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme. International Journal of Cancer. Journal International Du Cancer. 127: 2257-67. PMID 20162579 DOI: 10.1002/Ijc.25257  0.377
2010 Thoennissen NH, Krug UO, Lee DH, Kawamata N, Iwanski GB, Lasho T, Weiss T, Nowak D, Koren-Michowitz M, Kato M, Sanada M, Shih LY, Nagler A, Raynaud SD, Müller-Tidow C, ... ... Koeffler HP, et al. Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms. Blood. 115: 2882-90. PMID 20068225 DOI: 10.1182/Blood-2009-07-235119  0.536
2010 Mishra DK, Chen Z, Wu Y, Sarkissyan M, Koeffler HP, Vadgama JV. Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells. Molecular Cancer Therapeutics. 9: 33-45. PMID 20053773 DOI: 10.1158/1535-7163.Mct-09-0486  0.353
2010 Nowak D, Ogawa S, Müschen M, Kato M, Kawamata N, Meixel A, Nowak V, Kim HS, Kang S, Paquette R, Chang MS, Thoennissen NH, Thoenissen NH, Mossner M, Hofmann WK, ... ... Koeffler HP, et al. SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations. Blood. 115: 1049-53. PMID 19965645 DOI: 10.1182/Blood-2009-03-210377  0.334
2010 Thoennissen NH, Kyme P, Tseng CW, Iwanski GB, Shimada K, Krug UO, Gombart A, Koeffler HP, Liu GY. CCAAT/Enhancer Binding Protein Epsilon Mediates Nicotinamide-Enhanced Clearance of Staphylococcus Aureus Infection Blood. 116: 925-925. DOI: 10.1182/Blood.V116.21.925.925  0.301
2010 Nagata Y, Sanada M, Yoshida K, Nakaya T, Matsubara A, Obara N, Ishiyama K, Miyawaki S, Takita J, Chiba S, Shih L, Koeffler HP, Ogawa S. Profiling of Multiple Gene Mutations In Myelodysplastic Syndromes Using High-Throughput Resequenceing Combined with Barcode Labeling Blood. 116: 4011-4011. DOI: 10.1182/Blood.V116.21.4011.4011  0.336
2010 Tabayashi T, Gery S, Koren-Michowitz M, Koeffler H. Adaptor Protein Lnk Negatively Regulates Bcr-Abl-Induced Cell Proliferation through Inhibition of the Stat5 Signaling Pathway. Blood. 116: 3406-3406. DOI: 10.1182/Blood.V116.21.3406.3406  0.424
2010 Iwanski GB, Thoennissen NH, Nakitandwe J, Lin P, Kawamata N, Nahar R, Ramezani-Rad P, Chen S, Shurtleff S, Nowak D, Ruckert C, Dugas M, Bokemeyer C, Fazio G, Biondi A, ... ... Koeffler HP, et al. Dominant-Negative Impact of PAX5/TEL on Downstream Targets of PAX5 and Essential Pre-B Cell Receptor Genes Blood. 116: 3231-3231. DOI: 10.1182/Blood.V116.21.3231.3231  0.411
2010 koren-Michowitz M, Gery S, Nowak D, Nagler A, Matsubara A, Tabayashi T, Ogawa S, Koeffler HP. Adaptor Protein LNK Binds to and Is Phosphorylated by JAK3 and May Serve as a Scaffold for JAK3 Autophosphorylation In the Absence of An Appropriate Cytokine Receptor Blood. 116: 2785-2785. DOI: 10.1182/Blood.V116.21.2785.2785  0.349
2010 Lee DH, Thoennissen NH, Goff CB, Iwanski GB, Doan NB, Toh M, Chan T, Said JW, Koeffler HP. Abstract 5396: Synergistic effect of cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma Cancer Research. 70: 5396-5396. DOI: 10.1158/1538-7445.Am10-5396  0.564
2010 Chien W, Kawamata N, Okemoto K, Ogawa S, Koeffler HP. Abstract 4994: Association of protein inhibitor of activated STAT protein 4 with the development of pancreatic ductal adenocarcinoma identified by chromosomal analysis from single nucleotide polymorphism arrays Cancer Research. 70: 4994-4994. DOI: 10.1158/1538-7445.Am10-4994  0.397
2010 Shang X, Wu Y, Sarkissyan M, Koeffler HP, Vadgama JV. Abstract 4072: Overexpression of FOXO1 increased sensitivity to Tamoxifen in MCF7 cells, and is associated with estrogen receptor α (ERα) expression Cancer Research. 70: 4072-4072. DOI: 10.1158/1538-7445.Am10-4072  0.414
2010 Koren-Michowitz M, Gery S, Nowak D, Koeffler HP. Abstract 4010: Adaptor protein Lnk binds to JAK3 and negatively regulates a mutant activating allele associated with megakaryocytic leukemia Cancer Research. 70: 4010-4010. DOI: 10.1158/1538-7445.Am10-4010  0.394
2010 Sarkissyan S, Sarkissyan M, Wu Y, Koeffler HP, Vadgama JV. Abstract 3131: IGF-I regulates Cyr61-induced breast cancer cell growth and migration Cancer Research. 70: 3131-3131. DOI: 10.1158/1538-7445.Am10-3131  0.389
2010 Thoennissen NH, Iwanski GB, Ji J, Ikezoe T, Lee K, Adachi Y, Takeuchi T, Furihata M, Park DJ, Gombart AF, Koeffler HP. Abstract 245: An oncogenic role forCCAAT/enhancer binding protein betain non-small cell lung cancer Cellular and Molecular Biology. 70: 245-245. DOI: 10.1158/1538-7445.Am10-245  0.323
2009 Gery S, Koeffler HP. Per2 is a C/EBP target gene implicated in myeloid leukemia. Integrative Cancer Therapies. 8: 317-20. PMID 19926610 DOI: 10.1177/1534735409352084  0.434
2009 Ikezoe T, Takeuchi T, Yang J, Adachi Y, Nishioka C, Furihata M, Koeffler HP, Yokoyama A. Analysis of Aurora B kinase in non-Hodgkin lymphoma. Laboratory Investigation; a Journal of Technical Methods and Pathology. 89: 1364-73. PMID 19823168 DOI: 10.1182/Blood.V112.11.1610.1610  0.354
2009 Akagi T, Shih LY, Ogawa S, Gerss J, Moore SR, Schreck R, Kawamata N, Liang DC, Sanada M, Nannya Y, Deneberg S, Zachariadis V, Nordgren A, Song JH, Dugas M, ... ... Koeffler HP, et al. Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells. Haematologica. 94: 1301-6. PMID 19734423 DOI: 10.3324/Haematol.2009.005744  0.331
2009 Zang C, Liu H, Bertz J, Possinger K, Koeffler HP, Elstner E, Eucker J. Induction of endoplasmic reticulum stress response by TZD18, a novel dual ligand for peroxisome proliferator-activated receptor alpha/gamma, in human breast cancer cells. Molecular Cancer Therapeutics. 8: 2296-307. PMID 19671747 DOI: 10.1158/1535-7163.Mct-09-0347  0.398
2009 Akagi T, Ito T, Kato M, Jin Z, Cheng Y, Kan T, Yamamoto G, Olaru A, Kawamata N, Boult J, Soukiasian HJ, Miller CW, Ogawa S, Meltzer SJ, Koeffler HP. Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinoma. International Journal of Cancer. Journal International Du Cancer. 125: 2349-59. PMID 19670330 DOI: 10.1002/Ijc.24620  0.364
2009 Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, ... ... Koeffler HP, et al. Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature. 460: 904-8. PMID 19620960 DOI: 10.1038/Nature08240  0.378
2009 Thoennissen NH, Iwanski GB, Doan NB, Okamoto R, Lin P, Abbassi S, Song JH, Yin D, Toh M, Xie WD, Said JW, Koeffler HP. Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells. Cancer Research. 69: 5876-84. PMID 19605406 DOI: 10.1158/0008-5472.Can-09-0536  0.395
2009 Nishioka C, Ikezoe T, Yang J, Gery S, Koeffler HP, Yokoyama A. Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells. International Journal of Cancer. 125: 1710-20. PMID 19507250 DOI: 10.1002/Ijc.24472  0.421
2009 Yin D, Ogawa S, Kawamata N, Tunici P, Finocchiaro G, Eoli M, Ruckert C, Huynh T, Liu G, Kato M, Sanada M, Jauch A, Dugas M, Black KL, Koeffler HP. High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarray. Molecular Cancer Research : McR. 7: 665-77. PMID 19435819 DOI: 10.1158/1541-7786.Mcr-08-0270  0.379
2009 Kawamata N, Ogawa S, Seeger K, Kirschner-Schwabe R, Huynh T, Chen J, Megrabian N, Harbott J, Zimmermann M, Henze G, Schrappe M, Bartram CR, Koeffler HP. Molecular allelokaryotyping of relapsed pediatric acute lymphoblastic leukemia. International Journal of Oncology. 34: 1603-12. PMID 19424578 DOI: 10.3892/Ijo_00000290  0.301
2009 Nishioka C, Ikezoe T, Yang J, Komatsu N, Koeffler HP, Yokoyama A. Blockade of MEK signaling potentiates 5-Aza-2'-deoxycytidine-induced apoptosis and upregulation of p21(waf1) in acute myelogenous leukemia cells. International Journal of Cancer. 125: 1168-76. PMID 19422044 DOI: 10.1002/Ijc.24377  0.4
2009 Gery S, Gueller S, Nowak V, Sohn J, Hofmann WK, Koeffler HP. Expression of the adaptor protein Lnk in leukemia cells. Experimental Hematology. 37: 585-592.e2. PMID 19375649 DOI: 10.1016/J.Exphem.2009.01.009  0.411
2009 Gery S, Cao Q, Gueller S, Xing H, Tefferi A, Koeffler HP. Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F. Journal of Leukocyte Biology. 85: 957-65. PMID 19293402 DOI: 10.1189/Jlb.0908575  0.377
2009 Nowak D, Le Toriellec E, Stern MH, Kawamata N, Akagi T, Dyer MJ, Hofmann WK, Ogawa S, Koeffler HP. Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy. Haematologica. 94: 518-27. PMID 19278963 DOI: 10.3324/Haematol.2008.001347  0.344
2009 Nowak D, Stewart D, Koeffler HP. Differentiation therapy of leukemia: 3 decades of development. Blood. 113: 3655-65. PMID 19221035 DOI: 10.1182/Blood-2009-01-198911  0.339
2009 Akagi T, Ogawa S, Dugas M, Kawamata N, Yamamoto G, Nannya Y, Sanada M, Miller CW, Yung A, Schnittger S, Haferlach T, Haferlach C, Koeffler HP. Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype. Haematologica. 94: 213-23. PMID 19144660 DOI: 10.3324/Haematol.13024  0.327
2009 Bertz J, Zang C, Liu H, Wächter M, Possinger K, Koeffler HP, Elstner E. Compound 48, a novel dual PPAR alpha/gamma ligand, inhibits the growth of human CML cell lines and enhances the anticancer-effects of imatinib. Leukemia Research. 33: 686-92. PMID 19131110 DOI: 10.1016/J.Leukres.2008.11.023  0.353
2009 Akagi T, Shih LY, Kato M, Kawamata N, Yamamoto G, Sanada M, Okamoto R, Miller CW, Liang DC, Ogawa S, Koeffler HP. Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations. Blood. 113: 1741-8. PMID 19109227 DOI: 10.1182/Blood-2007-12-130260  0.305
2009 Kumagai T, Akagi T, Desmond JC, Kawamata N, Gery S, Imai Y, Song JH, Gui D, Said J, Koeffler HP. Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells. International Journal of Cancer. 124: 827-33. PMID 19035457 DOI: 10.1002/Ijc.23994  0.413
2009 Kawamata N, Zhang L, Ogawa S, Nannya Y, Dashti A, Lu D, Lim S, Schreck R, Koeffler HP. Double minute chromosomes containing MYB gene and NUP214-ABL1 fusion gene in T-cell leukemia detected by single nucleotide polymorphism DNA microarray and fluorescence in situ hybridization Leukemia Research. 33: 569-571. PMID 18799215 DOI: 10.1016/J.Leukres.2008.07.030  0.354
2009 Gueller S, Gery S, Nowak V, Liu L, Serve H, Koeffler HP. Adaptor protein Lnk associates with Tyr(568) in c-Kit. The Biochemical Journal. 415: 241-5. PMID 18588518 DOI: 10.1042/Bj20080102  0.33
2009 Thoennissen NH, Akagi T, Song JH, Iwanski GB, Koeffler HP. In Vivo Deficiency of Both Transcription Factors, C/EBPbeta and C/EBPepsilon, Results in Lack of Cytokine Response and a High Susceptibility for Overwhelming Infections. Blood. 114: 3641-3641. DOI: 10.1182/Blood.V114.22.3641.3641  0.345
2009 Iwanski GB, Thoennissen NH, Lor P, Kawamata N, Nowak D, Fazio G, Biondi A, Gazzaniga G, Koeffler HP. PAX5/TEL Exhibits a Dominant-Negative Role by Inhibiting the Expression of Genes Involved in BCR Signalling and Suppressing the Binding of Wild Type PAX5 to Its Direct Target Gene CD79A (mb-1) in a human Pre-B ALL Cell Line. Blood. 114: 3455-3455. DOI: 10.1182/Blood.V114.22.3455.3455  0.433
2009 Thoennissen NH, Iwanski GB, Doan B, Gery S, Said JW, Koeffler HP. CEBPalpha and a Critical Circadian Clock Downstream Target Gene, PER2, Are Highly Dysregulated in Diffuse Large B-Cell Lymphoma. Blood. 114: 3454-3454. DOI: 10.1182/Blood.V114.22.3454.3454  0.425
2008 Walsh CS, Ogawa S, Scoles DR, Miller CW, Kawamata N, Narod SA, Koeffler HP, Karlan BY. Genome-wide loss of heterozygosity and uniparental disomy in BRCA1/2-associated ovarian carcinomas. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 7645-51. PMID 19047089 DOI: 10.1158/1078-0432.Ccr-08-1291  0.326
2008 Haritunians T, Gueller S, O'Kelly J, Ilaria R, Koeffler HP. Novel acyl sulfonamide LY573636-sodium: effect on hematopoietic malignant cells. Oncology Reports. 20: 1237-42. PMID 18949427 DOI: 10.3892/Or_00000135  0.405
2008 Saito T, Okamoto R, Haritunians T, O'Kelly J, Uskokovic M, Maehr H, Marczak S, Jankowski P, Badr R, Koeffler HP. Novel Gemini vitamin D(3) analogs have potent antitumor activity. The Journal of Steroid Biochemistry and Molecular Biology. 112: 151-6. PMID 18938245 DOI: 10.1016/J.Jsbmb.2008.09.012  0.359
2008 Nishioka C, Ikezoe T, Yang J, Koeffler HP, Yokoyama A. Blockade of mTOR signaling potentiates the ability of histone deacetylase inhibitor to induce growth arrest and differentiation of acute myelogenous leukemia cells. Leukemia. 22: 2159-68. PMID 18784743 DOI: 10.1182/Blood.V112.11.1612.1612  0.393
2008 Wakimoto N, Wolf I, Yin D, O'Kelly J, Akagi T, Abramovitz L, Black KL, Tai HH, Koeffler HP. Nonsteroidal anti-inflammatory drugs suppress glioma via 15-hydroxyprostaglandin dehydrogenase. Cancer Research. 68: 6978-86. PMID 18757412 DOI: 10.1158/0008-5472.Can-07-5675  0.382
2008 Kawamata N, Ogawa S, Yamamoto G, Lehmann S, Levine RL, Pikman Y, Nannya Y, Sanada M, Miller CW, Gilliland DG, Koeffler HP. Genetic profiling of myeloproliferative disorders by single-nucleotide polymorphism oligonucleotide microarray. Experimental Hematology. 36: 1471-9. PMID 18723266 DOI: 10.1016/j.exphem.2008.06.006  0.321
2008 Kawamata N, Ogawa S, Zimmermann M, Niebuhr B, Stocking C, Sanada M, Hemminki K, Yamatomo G, Nannya Y, Koehler R, Flohr T, Miller CW, Harbott J, Ludwig WD, Stanulla M, ... ... Koeffler HP, et al. Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray. Proceedings of the National Academy of Sciences of the United States of America. 105: 11921-6. PMID 18697940 DOI: 10.1073/Pnas.0711039105  0.399
2008 Lübbert M, Müller-Tidow C, Hofmann WK, Koeffler HP. Advances in the treatment of acute myeloid leukemia: from chromosomal aberrations to biologically targeted therapy. Journal of Cellular Biochemistry. 104: 2059-70. PMID 18613031 DOI: 10.1002/Jcb.21770  0.322
2008 Yin D, Wakimoto N, Xing H, Lu D, Huynh T, Wang X, Black KL, Koeffler HP. Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme. International Journal of Cancer. Journal International Du Cancer. 123: 1364-75. PMID 18561312 DOI: 10.1002/Ijc.23648  0.338
2008 Campbell MJ, Carlberg C, Koeffler HP. A Role for the PPARgamma in Cancer Therapy. Ppar Research. 2008: 314974. PMID 18528521 DOI: 10.1155/2008/314974  0.337
2008 Haritunians T, Gueller S, Zhang L, Badr R, Yin D, Xing H, Fung MC, Koeffler HP. Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells. Leukemia Research. 32: 1366-73. PMID 18405967 DOI: 10.1016/J.Leukres.2008.01.019  0.381
2008 Nishioka C, Ikezoe T, Yang J, Takeuchi S, Koeffler HP, Yokoyama A. MS-275, a novel histone deacetylase inhibitor with selectivity against HDAC1, induces degradation of FLT3 via inhibition of chaperone function of heat shock protein 90 in AML cells. Leukemia Research. 32: 1382-92. PMID 18394702 DOI: 10.1016/J.Leukres.2008.02.018  0.352
2008 Nishioka C, Ikezoe T, Yang J, Miwa A, Tasaka T, Kuwayama Y, Togitani K, Koeffler HP, Yokoyama A. Kill502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo Blood. 111: 5086-5092. PMID 18309036 DOI: 10.1182/Blood-2007-06-098079  0.42
2008 Wang Y, Liu D, Chen P, Koeffler HP, Tong X, Xie D. Negative feedback regulation of IFN-gamma pathway by IFN regulatory factor 2 in esophageal cancers. Cancer Research. 68: 1136-43. PMID 18281489 DOI: 10.1158/0008-5472.Can-07-5021  0.355
2008 Lehmann S, Ogawa S, Raynaud SD, Sanada M, Nannya Y, Ticchioni M, Bastard C, Kawamata N, Koeffler HP. Molecular allelokaryotyping of early-stage, untreated chronic lymphocytic leukemia. Cancer. 112: 1296-305. PMID 18246537 DOI: 10.1002/Cncr.23270  0.31
2008 Nishioka C, Ikezoe T, Yang J, Komatsu N, Bandobashi K, Taniguchi A, Kuwayama Y, Togitani K, Koeffler HP, Taguchi H. Histone deacetylase inhibitors induce growth arrest and apoptosis of HTLV-1-infected T-cells via blockade of signaling by nuclear factor κB Leukemia Research. 32: 287-296. PMID 17644177 DOI: 10.1016/J.Leukres.2007.05.026  0.362
2008 Masashi S, Yung SL, Suzuki T, Kato M, Sakata MY, Kumano K, Kawamata N, Takita J, Mori H, Kurokawa M, Chiba S, Omine M, Koeffler HP, Ogawa S. Genome-Wide Analysis of MDS/MPD Disclosed Frequent Homozygous C-Cbl mutations Tightly Associated with 11q-UPD Blood. 112: 855-855. DOI: 10.1182/Blood.V112.11.855.855  0.343
2008 Thoennissen NH, Cao Q, Doan B, Abbassi S, Nowak D, Müller-Tidow C, Said J, Gary S, Koeffler HP. Expression of Circadian Core Clock Gene Per2 Is Markedly Down-Regulated in Diffuse Large B-Cell Lymphoma Blood. 112: 4470-4470. DOI: 10.1182/Blood.V112.11.4470.4470  0.405
2008 Kawamata N, Isken F, Goellner S, Müller-Tidow C, Koeffler HP. ChIP-on-Chip Analysis Using Dominant Negative Form of PAX5 Fusion Gene Revealed Genes Associated with Tumorigenesis Were Directly Regulated by PAX5 in a Human B Cell Line, NALM6 Blood. 112: 3585-3585. DOI: 10.1182/Blood.V112.11.3585.3585  0.411
2008 Nowak D, Kawamata N, Akagi T, Okamoto R, Thoennissen N, Hofmann W, Kato M, Haferlach T, Ogawa S, Koeffler HP. High Density SNP Array Analysis of Tyrosine Kinase Inhibitor (TKI) Resistant Chronic Myeloid Leukemia (CML) Shows Secondary Genomic Alterations Blood. 112: 3182-3182. DOI: 10.1182/Blood.V112.11.3182.3182  0.352
2007 Liu DP, Qi RZ, Wang Y, Chen PP, Koeffler HP, Xie D. Discovery of stage-related proteins in esophageal squamous cell carcinoma using proteomic analysis. Proteomics. Clinical Applications. 1: 312-20. PMID 21136681 DOI: 10.1002/Prca.200600815  0.317
2007 Akagi T, Saitoh T, O'Kelly J, Akira S, Gombart AF, Koeffler HP. Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C/EBPbeta-deficient hematopoietic cells. Blood. 111: 2999-3004. PMID 18056834 DOI: 10.1182/Blood-2007-04-087213  0.334
2007 Nishioka C, Ikezoe T, Yang J, Takeshita A, Taniguchi A, Komatsu N, Togitani K, Koeffler HP, Yokoyama A. Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene. Leukemia Research. 32: 865-72. PMID 17983653 DOI: 10.1016/J.Leukres.2007.09.017  0.392
2007 Deng YZ, Chen PP, Wang Y, Yin D, Koeffler HP, Li B, Tong XJ, Xie D. Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signaling. The Journal of Biological Chemistry. 282: 36571-81. PMID 17951630 DOI: 10.1074/Jbc.M704141200  0.347
2007 Wang J, Yong WH, Sun Y, Vernier PT, Koeffler HP, Gundersen MA, Marcu L. Receptor-targeted quantum dots: fluorescent probes for brain tumor diagnosis. Journal of Biomedical Optics. 12: 044021. PMID 17867825 DOI: 10.1117/1.2764463  0.307
2007 Gery S, Gueller S, Chumakova K, Kawamata N, Liu L, Koeffler HP. Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders. Blood. 110: 3360-4. PMID 17693582 DOI: 10.1182/Blood-2007-05-089326  0.404
2007 Kawamata N, Chen J, Koeffler HP. Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells. Blood. 110: 2667-73. PMID 17606765 DOI: 10.1182/Blood-2005-11-026344  0.366
2007 Yamamoto G, Nannya Y, Kato M, Sanada M, Levine RL, Kawamata N, Hangaishi A, Kurokawa M, Chiba S, Gilliland DG, Koeffler HP, Ogawa S. Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays. American Journal of Human Genetics. 81: 114-26. PMID 17564968 DOI: 10.1086/518809  0.347
2007 Yang J, Ikezoe T, Nishioka C, Tasaka T, Taniguchi A, Kuwayama Y, Komatsu N, Bandobashi K, Togitani K, Koeffler HP, Taguchi H, Yokoyama A. AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo Blood. 110: 2034-2040. PMID 17495131 DOI: 10.1182/Blood-2007-02-073700  0.388
2007 Tanaka M, Gombart AF, Koeffler HP, Shiohara M. Expression of bactericidal/permeability-increasing protein requires C/EBP epsilon. International Journal of Hematology. 85: 304-11. PMID 17483073 DOI: 10.1532/Ijh97.05162  0.388
2007 Garon EB, Sawcer D, Vernier PT, Tang T, Sun Y, Marcu L, Gundersen MA, Koeffler HP. In vitro and in vivo evaluation and a case report of intense nanosecond pulsed electric field as a local therapy for human malignancies. International Journal of Cancer. Journal International Du Cancer. 121: 675-82. PMID 17417774 DOI: 10.1002/Ijc.22723  0.364
2007 Kumagai T, Wakimoto N, Yin D, Gery S, Kawamata N, Takai N, Komatsu N, Chumakov A, Imai Y, Koeffler HP. Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells. International Journal of Cancer. 121: 656-65. PMID 17417771 DOI: 10.1002/Ijc.22558  0.444
2007 Gery S, Park DJ, Vuong PT, Virk RK, Muller CI, Hofmann WK, Koeffler HP. RTP801 is a novel retinoic acid-responsive gene associated with myeloid differentiation. Experimental Hematology. 35: 572-8. PMID 17379067 DOI: 10.1016/J.Exphem.2007.01.049  0.306
2007 Wang Y, Liu DP, Chen PP, Koeffler HP, Tong XJ, Xie D. Involvement of IFN regulatory factor (IRF)-1 and IRF-2 in the formation and progression of human esophageal cancers. Cancer Research. 67: 2535-43. PMID 17363571 DOI: 10.1158/0008-5472.Can-06-3530  0.424
2007 Gombart AF, Grewal J, Koeffler HP. ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalpha. Journal of Leukocyte Biology. 81: 1535-47. PMID 17347301 DOI: 10.1189/Jlb.0806516  0.321
2007 Gery S, Komatsu N, Kawamata N, Miller CW, Desmond J, Virk RK, Marchevsky A, Mckenna R, Taguchi H, Koeffler HP. Epigenetic silencing of the candidate tumor suppressor gene Per1 in non-small cell lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 1399-404. PMID 17332281 DOI: 10.1158/1078-0432.Ccr-06-1730  0.369
2007 Wolf I, Bose S, Desmond JC, Lin BT, Williamson EA, Karlan BY, Koeffler HP. Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer. Breast Cancer Research and Treatment. 105: 139-55. PMID 17295047 DOI: 10.1007/S10549-006-9440-4  0.392
2007 Yin D, Ong JM, Hu J, Desmond JC, Kawamata N, Konda BM, Black KL, Koeffler HP. Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 1045-52. PMID 17289901 DOI: 10.1158/1078-0432.Ccr-06-1261  0.364
2007 Gery S, Koeffler HP. Transcription factors in hematopoietic malignancies. Current Opinion in Genetics & Development. 17: 78-83. PMID 17210248 DOI: 10.1016/J.Gde.2006.12.012  0.368
2007 Wolf I, Bose S, Williamson EA, Miller CW, Karlan BY, Koeffler HP. FOXA1: Growth inhibitor and a favorable prognostic factor in human breast cancer. International Journal of Cancer. Journal International Du Cancer. 120: 1013-22. PMID 17163418 DOI: 10.1002/Ijc.22389  0.366
2007 Walsh CS, Miller CW, Karlan BY, Koeffler HP. Association between a functional single nucleotide polymorphism in the MDM2 gene and sporadic endometrial cancer risk. Gynecologic Oncology. 104: 660-4. PMID 17123590 DOI: 10.1016/J.Ygyno.2006.10.008  0.307
2007 Ikezoe T, Nishioka C, Tasaka T, Yang Y, Komatsu N, Togitani K, Koeffler HP, Taguchi H. The antitumor effects of sunitinib (formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling. Molecular Cancer Therapeutics. 5: 2522-30. PMID 17041096 DOI: 10.1158/1535-7163.Mct-06-0071  0.432
2007 Garon EB, Marcu L, Luong Q, Tcherniantchouk O, Crooks GM, Koeffler HP. Quantum dot labeling and tracking of human leukemic, bone marrow and cord blood cells. Leukemia Research. 31: 643-51. PMID 17027955 DOI: 10.1016/J.Leukres.2006.08.006  0.325
2007 Kumagai T, Müller CI, Desmond JC, Imai Y, Heber D, Koeffler HP. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Leukemia Research. 31: 523-30. PMID 17007926 DOI: 10.1016/J.Leukres.2006.08.019  0.373
2007 Ikezoe T, Nishioka C, Bandobashi K, Yang Y, Kuwayama Y, Adachi Y, Takeuchi T, Koeffler HP, Taguchi H. Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells Leukemia Research. 31: 673-682. PMID 17007924 DOI: 10.1016/J.Leukres.2006.08.001  0.378
2007 Müller CI, Miller CW, Hofmann WK, Gross ME, Walsh CS, Kawamata N, Luong QT, Koeffler HP. Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseudogene. Leukemia Research. 31: 27-32. PMID 16764926 DOI: 10.1016/J.Leukres.2006.04.011  0.362
2007 Yin D, Kawabata H, Tcherniamtchouk O, Huynh T, Black KL, Koeffler HP. Glioblastoma multiforme cells: Expression of erythropoietin receptor and response to erythropoietin International Journal of Oncology. 31: 1193-1198. DOI: 10.3892/Ijo.31.5.1193  0.41
2007 Yang Y, Ikezoe T, Zheng Z, Taguchi H, Koeffler HP, Zhu W. Saw Palmetto induces growth arrest and apoptosis of androgen-dependent prostate cancer LNCaP cells via inactivation of STAT 3 and androgen receptor signaling. International Journal of Oncology. 31: 593-600. DOI: 10.3892/Ijo.31.3.593  0.357
2007 Wolf I, O'Kelly J, Wakimoto N, Nguyen A, Amblard F, Karlan BY, Arbiser JL, Koeffler HP. Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest. International Journal of Oncology. 30: 1529-1537. DOI: 10.3892/Ijo.30.6.1529  0.329
2007 Liu DP, Wang Y, Koeffler HP, Xie D. Ephrin-A1 is a negative regulator in glioma through down-reguation of EphA2 and FAK International Journal of Oncology. 30: 865-871. DOI: 10.3892/Ijo.30.4.865  0.321
2007 Yin D, Komatsu N, Miller CW, Chumakov AM, Marschesky A, McKenna R, Black KL, Koeffler HP. KLF6: Mutational analysis and effect on cancer cell proliferation International Journal of Oncology. 30: 65-72. DOI: 10.3892/Ijo.30.1.65  0.396
2007 Chen P, Li W, Wang Y, Zhao S, Li D, Feng L, Shi X, Koeffler HP, Tong X, Xie D. Expression of Cyr61, CTGF, and WISP-1 Correlates with Clinical Features of Lung Cancer Plos One. 2: e534. DOI: 10.1371/Journal.Pone.0000534  0.319
2007 Okamoto R, Saito T, Haritunians T, O’Kelly J, Uskokovic M, Koeffler HP. Novel Deuterated Gemini-Vitamin D3 Analogs Have Potent Antitumor Activity. Blood. 110: 4210-4210. DOI: 10.1182/Blood.V110.11.4210.4210  0.392
2007 Akagi T, Ogawa S, Yamamoto G, Sanada M, Kawamata N, Miller CW, Liang D, Shih L, Koeffler HP. Hidden Abnormalities and Novel Classification of t(15;17) APL Based on Genomic Alterations. Blood. 110: 4133-4133. DOI: 10.1182/Blood.V110.11.4133.4133  0.323
2007 Xing H, Zhang S, Koeffler HP, Fung MC. Cucurbitacin D Upregulates Fetal Hemoglobin Expression in K562 Cells and Human Erythroid Progenitors. Blood. 110: 3833-3833. DOI: 10.1182/Blood.V110.11.3833.3833  0.358
2007 Okamoto R, Ogawa S, Akagi T, Kato M, Sanada M, Miller CW, Kawamata N, Haferlach C, Haferlach T, Koeffler HP. Genetic Profiling of Adult Acute Lymphoblastic Leukemia Cells by Single Nucleotide Polymorphism Oligonucleotide Microarray. Blood. 110: 2807-2807. DOI: 10.1182/Blood.V110.11.2807.2807  0.318
2007 Gueller S, Gery S, Koeffler HP. Adaptor Protein Lnk Binds to PDGFRA, PDGFRB and FIP1L1-PDGFRA, but Not to the TEL-PDGFRB Fusion Protein. Blood. 110: 2213-2213. DOI: 10.1182/Blood.V110.11.2213.2213  0.348
2007 Akagi T, Ogawa S, Yamamoto G, Nannya Y, Sanada M, Kawamata N, Miller CW, Dugas M, Schnittger S, Haferlach T, Haferlach C, Koeffler HP. Numerous Genomic Abnormalities in AML with Normal Karyotype. Blood. 110: 1811-1811. DOI: 10.1182/Blood.V110.11.1811.1811  0.354
2007 Gery S, Gueller S, Sohn J, Nabavinouri S, Leiter A, Koeffler HP. Adaptor Protein Lnk Negatively Regulates Mutant MPL and JAK2 Alleles Associated with Myeloproliferative Disorders Blood. 110: 1531-1531. DOI: 10.1182/Blood.V110.11.1531.1531  0.374
2006 Gombart AF, O'Kelly J, Saito T, Koeffler HP. Regulation of the CAMP gene by 1,25(OH)2D3 in various tissues. The Journal of Steroid Biochemistry and Molecular Biology. 103: 552-7. PMID 17368184 DOI: 10.1016/J.Jsbmb.2006.12.095  0.375
2006 Zang C, Liu H, Waechter M, Eucker J, Bertz J, Possinger K, Koeffler HP, Elstner E. Dual PPARalpha/gamma ligand TZD18 either alone or in combination with imatinib inhibits proliferation and induces apoptosis of human CML cell lines. Cell Cycle (Georgetown, Tex.). 5: 2237-43. PMID 17102607 DOI: 10.4161/Cc.5.19.3259  0.404
2006 Müller CI, Rüter B, Koeffler HP, Lübbert M. DNA hypermethylation of myeloid cells, a novel therapeutic target in MDS and AML. Current Pharmaceutical Biotechnology. 7: 315-21. PMID 17076647 DOI: 10.2174/138920106778521523  0.371
2006 Luong QT, O'Kelly J, Braunstein GD, Hershman JM, Koeffler HP. Antitumor activity of suberoylanilide hydroxamic acid against thyroid cancer cell lines in vitro and in vivo. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 5570-7. PMID 17000694 DOI: 10.1158/1078-0432.Ccr-06-0367  0.335
2006 Yang Y, Ikezoe T, Nishioka C, Taguchi T, Zhu WG, Koeffler HP, Taguchi H. ZD6474 induces growth arrest and apoptosis of GIST-T1 cells, which is enhanced by concomitant use of sunitinib. Cancer Science. 97: 1404-9. PMID 16995874 DOI: 10.1111/J.1349-7006.2006.00325.X  0.37
2006 Ikezoe T, Yang Y, Nishioka C, Bandobashi K, Nakatani H, Taguchi T, Koeffler HP, Taguchi H. Effect of SU11248 on gastrointestinal stromal tumor-T1 cells: enhancement of growth inhibition via inhibition of 3-kinase/Akt/mammalian target of rapamycin signaling. Cancer Science. 97: 945-51. PMID 16916320 DOI: 10.1111/J.1349-7006.2006.00263.X  0.39
2006 Wolf I, O'Kelly J, Rubinek T, Tong M, Nguyen A, Lin BT, Tai HH, Karlan BY, Koeffler HP. 15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer. Cancer Research. 66: 7818-23. PMID 16885386 DOI: 10.1158/0008-5472.Can-05-4368  0.394
2006 Chien W, Yin D, Gui D, Mori A, Frank JM, Said J, Kusuanco D, Marchevsky A, McKenna R, Koeffler HP. Suppression of cell proliferation and signaling transduction by connective tissue growth factor in non-small cell lung cancer cells Molecular Cancer Research. 4: 591-598. PMID 16877704 DOI: 10.1158/1541-7786.Mcr-06-0029  0.363
2006 O'Kelly J, Uskokovic M, Lemp N, Vadgama J, Koeffler HP. Novel Gemini-vitamin D3 analog inhibits tumor cell growth and modulates the Akt/mTOR signaling pathway Journal of Steroid Biochemistry and Molecular Biology. 100: 107-116. PMID 16777406 DOI: 10.1016/J.Jsbmb.2006.04.003  0.376
2006 Gery S, Komatsu N, Baldjyan L, Yu A, Koo D, Koeffler HP. The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Molecular Cell. 22: 375-82. PMID 16678109 DOI: 10.1016/j.molcel.2006.03.038  0.31
2006 Mori A, Lehmann S, O'Kelly J, Kumagai T, Desmond JC, Pervan M, McBride WH, Kizaki M, Koeffler HP. Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells. Cancer Research. 66: 3222-9. PMID 16540674 DOI: 10.1158/0008-5472.Can-05-0087  0.352
2006 Ikezoe T, Bandobashi K, Yang Y, Takeuchi S, Sekiguchi N, Sakai S, Koeffler HP, Taguchi H. HIV-1 protease inhibitor ritonavir potentiates the effect of 1,25-dihydroxyvitamin D3 to induce growth arrest and differentiation of human myeloid leukemia cells via down-regulation of CYP24. Leukemia Research. 30: 1005-11. PMID 16457885 DOI: 10.1016/J.Leukres.2005.12.008  0.332
2006 Müller CI, Kumagai T, O'Kelly J, Seeram NP, Heber D, Koeffler HP. Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells. Leukemia Research. 30: 841-8. PMID 16423392 DOI: 10.1016/J.Leukres.2005.12.004  0.358
2006 Liu H, Zang C, Fenner MH, Liu D, Possinger K, Koeffler HP, Elstner E. Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARalpha/gamma ligand TZD18. Blood. 107: 3683-92. PMID 16403907 DOI: 10.1182/Blood-2005-05-2103  0.411
2006 Takai N, Jain A, Kawamata N, Popoviciu LM, Said JW, Whittaker S, Miyakawa I, Agus DB, Koeffler HP. 2C4, a monoclonal antibody against HER2, disrupts the HER kinase signaling pathway and inhibits ovarian carcinoma cell growth. Cancer. 104: 2701-8. PMID 16265675 DOI: 10.1002/Cncr.21533  0.312
2006 Gombart AF, Borregaard N, Koeffler HP. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 1067-77. PMID 15985530 DOI: 10.1096/Fj.04-3284Com  0.364
2006 Yang Y, Ikezoe T, Takeuchi T, Adachi Y, Ohtsuki Y, Koeffler HP, Taguchi H. Zanthoxyli Fructus induces growth arrest and apoptosis of LNCaP human prostate cancer cells in vitro and in vivo in association with blockade of the AKT and AR signal pathways. Oncology Reports. 15: 1581-1590. DOI: 10.3892/Or.15.6.1581  0.399
2006 Komatsu N, Kawamata N, Takeuchi S, Yin D, Chien W, Miller CW, Koeffler HP. SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cells Oncology Reports. 15: 187-191. DOI: 10.3892/Or.15.1.187  0.398
2006 Ikezoe T, Yang Y, Saitoh T, Heber D, McKenna R, Taguchi H, Koeffler HP. PC-SPES down-regulates COX-2 via inhibition of NF-κB and C/EBPβ in non-small cell lung cancer cells International Journal of Oncology. 29: 453-461. DOI: 10.3892/Ijo.29.2.453  0.391
2006 Gombart AF, Koeffler HP. Vitamin D3-Mediated Regulation of Antimicrobial Peptide Expression by Ancient Transposable Elements Conserved Only in Humans and Primates. Blood. 108: 1638-1638. DOI: 10.1182/Blood.V108.11.1638.1638  0.335
2006 Gery S, Komatsu N, Baldjyan L, Yu A, Koo D, Koeffler HP. The Circadian Gene Per1 Plays an Important Role in Cell Growth and DNA Damage Control in Human Cancer Cells Molecular Cell. 22: 375-382. DOI: 10.1016/J.Molcel.2006.03.038  0.423
2005 Desmond JC, Kawabata H, Mueller-Tidow C, Simamura E, Heber D, Hirai K, Koeffler HP. The synthetic furanonaphthoquinone induces growth arrest, apoptosis and differentiation in a variety of leukaemias and multiple myeloma cells. British Journal of Haematology. 131: 520-9. PMID 16281944 DOI: 10.1111/J.1365-2141.2005.05803.X  0.389
2005 Paz-Priel I, Cai DH, Wang D, Kowalski J, Blackford A, Liu H, Heckman CA, Gombart AF, Koeffler HP, Boxer LM, Friedman AD. CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50. Molecular Cancer Research : McR. 3: 585-96. PMID 16254192 DOI: 10.1158/1541-7786.Mcr-05-0111  0.362
2005 Gombart AF, Krug U, O'Kelly J, An E, Vegesna V, Koeffler HP. Aberrant expression of neutrophil and macrophage-related genes in a murine model for human neutrophil-specific granule deficiency Journal of Leukocyte Biology. 78: 1153-1165. PMID 16204633 DOI: 10.1189/Jlb.0504286  0.345
2005 Yang Y, Ikezoe T, Takeuchi T, Adachi Y, Ohtsuki Y, Takeuchi S, Koeffler HP, Taguchi H. HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling. Cancer Science. 96: 425-33. PMID 16053514 DOI: 10.1111/J.1349-7006.2005.00063.X  0.369
2005 Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP. Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia. Blood. 106: 2827-36. PMID 15985538 DOI: 10.1182/Blood-2005-01-0358  0.42
2005 Ikezoe T, Gery S, Yin D, O'Kelly J, Binderup L, Lemp N, Taguchi H, Koeffler HP. CCAAT/enhancer-binding protein δ: A molecular target of 1,25-dihydroxyvitamin D 3 in androgen-responsive prostate cancer LNCaP cells Cancer Research. 65: 4762-4768. PMID 15930295 DOI: 10.1158/0008-5472.Can-03-3619  0.383
2005 Takai N, Kawamata N, Walsh CS, Gery S, Desmond JC, Whittaker S, Said JW, Popoviciu LM, Jones PA, Miyakawa I, Koeffler HP. Discovery of epigenetically masked tumor suppressor genes in endometrial cancer. Molecular Cancer Research : McR. 3: 261-9. PMID 15886297 DOI: 10.1158/1541-7786.Mcr-04-0110  0.407
2005 Gery S, Tanosaki S, Bose S, Bose N, Vadgama J, Koeffler HP. Down-regulation and growth inhibitory role of C/EBPalpha in breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 3184-90. PMID 15867211 DOI: 10.1158/1078-0432.Ccr-04-2625  0.321
2005 Jones LC, Tefferi A, Vuong PT, Desmond JC, Hofmann WK, Koeffler HP. Detection of aberrant gene expression in CD34+ hematopoietic stem cells from patients with agnogenic myeloid metaplasia using oligonucleotide microarrays. Stem Cells (Dayton, Ohio). 23: 631-7. PMID 15849170 DOI: 10.1634/Stemcells.2004-0131  0.344
2005 Ikezoe T, Yang Y, Bandobashi K, Saito T, Takemoto S, Machida H, Togitani K, Koeffler HP, Taguchi H. Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways. Molecular Cancer Therapeutics. 4: 578-86. PMID 15827331 DOI: 10.1158/1535-7163.Mct-04-0277  0.405
2005 Kumagai T, Tefferi A, Jones L, Koeffler HP. Methylation analysis of the cell cycle control genes in myelofibrosis with myeloid metaplasia. Leukemia Research. 29: 511-5. PMID 15755503 DOI: 10.1016/J.Leukres.2004.11.002  0.337
2005 Sakajiri S, Kumagai T, Kawamata N, Saitoh T, Said JW, Koeffler HP. Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines. Experimental Hematology. 33: 53-61. PMID 15661398 DOI: 10.1016/J.Exphem.2004.09.008  0.428
2005 Yin D, Zhou H, Kumagai T, Liu G, Ong JM, Black KL, Koeffler HP. Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM) Oncogene. 24: 344-354. PMID 15531918 DOI: 10.1038/sj.onc.1208225  0.309
2005 Worch J, Tickenbrock L, Schwäble J, Steffen B, Cauvet T, Mlody B, Buerger H, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C. The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells. Oncogene. 23: 9162-72. PMID 15516979 DOI: 10.1038/sj.onc.1208164  0.312
2005 Worch J, Tickenbrock L, Schwäble J, Steffen B, Cauvet T, Mlody B, Buerger H, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C. The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells. Oncogene. 23: 9162-72. PMID 15516979 DOI: 10.1038/sj.onc.1208164  0.312
2005 Servidei T, Morosetti R, Ferlini C, Cusano G, Scambia G, Mastrangelo R, Koeffler HP. The cellular response to PPARgamma ligands is related to the phenotype of neuroblastoma cell lines. Oncology Research. 14: 345-54. PMID 15301425 DOI: 10.3727/0965040041292297  0.393
2005 Mhawech P, Benz A, Cerato C, Greloz V, Assaly M, Desmond JC, Koeffler HP, Lodygin D, Hermeking H, Herrmann F, Schwaller J. Downregulation of 14-3-3sigma in ovary, prostate and endometrial carcinomas is associated with CpG island methylation. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 18: 340-8. PMID 15257317 DOI: 10.1038/Modpathol.3800240  0.374
2005 Morosetti R, Servidei T, Mirabella M, Rutella S, Mangiola A, Maira G, Mastrangelo R, Koeffler HP. The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines. International Journal of Oncology. 25: 493-502. PMID 15254749  0.301
2005 Müller CI, Miller CW, Kawabata H, McKenna RJ, Marchevsky AM, Koeffler HP. Do cancer cells selectively mutate HFE to increase their intracellular iron Oncology Reports. 14: 299-303. DOI: 10.3892/Or.14.2.299  0.395
2005 Matsushita M, Takeuchi S, Yang Y, Yoshino N, Tsukasaki K, Taguchi H, Koeffler HP, Seo H. Methylation of the MLH1 gene in hematological malignancies Oncology Reports. 14: 191-194. DOI: 10.3892/Or.14.1.191  0.374
2005 Kawamata N, Sugimoto K, Sakajiri S, Oshimi K, Koeffler HP. Mxi1 isoforms are expressed in hematological cell lines and normal bone marrow. International Journal of Oncology. 26: 1369-1375. DOI: 10.3892/Ijo.26.5.1369  0.346
2005 Muller CI, Luong QT, Jones LC, Desmond JC, Kawamata N, Tcherniantchouk T, Shih L, Ito Y, Ito K, Liu Q, Osato M, de Vos S, Koeffler HP. Identification of Marker Genes That Discriminate between Different Myeloproliferative Disorders and Normal Individuals Including RUNX3 (AML2). Blood. 106: 3522-3522. DOI: 10.1182/Blood.V106.11.3522.3522  0.354
2005 Gombart AF, Chen H, Brandi L, Olgaard K, Borregaard N, Adams JS, Koeffler HP. Vitamin D3-Mediated Regulation of the Antimicrobial Peptides CAMP and DEFB4 Is Evolutionarily Important for Innate Immunity in Humans and Primates. Blood. 106: 3079-3079. DOI: 10.1182/Blood.V106.11.3079.3079  0.337
2005 Paz-Priel I, Cai DH, Wang D, Kowalski J, Blackford A, Liu H, Heckman CA, Gombart AF, Koeffler HP, Boxer LM, Friedman AD. C/EBPα and C/EBPα Myeloid Oncoproteins Induce Bcl-2 Via Interaction of Their Basic Regions with NF-κB p50. Blood. 106: 2992-2992. DOI: 10.1182/Blood.V106.11.2992.2992  0.378
2005 Ikezoe T, Bandobashi K, Yang Y, Saito T, Togitani K, Tasaka T, Koeffler HP, Taguchi H. The Anti-Tumor Effects of SU11248, a Class III Receptor Tyrosine Kinase Inhibitor, Against a Variety of Human Hematological Malignancies. Blood. 106: 2795-2795. DOI: 10.1182/Blood.V106.11.2795.2795  0.412
2005 Gery S, Park DJ, Vuong PT, Koeffler HP. RTP801 Is a Novel Retinoic Acid Responsive Gene Possibly Involved in Myeloid Differentiation. Blood. 106: 2715-2715. DOI: 10.1182/Blood.V106.11.2715.2715  0.413
2005 Garon EB, Crooks GM, Tcherniantchouk O, Luong QT, Papaioannou T, Marcu L, Koeffler HP. Utility of Quantum Dots for Labeling and Tracking Leukemic Cell Lines, Human Bone Marrow and CD 34+ Umbilical Cord Blood. Blood. 106: 1729-1729. DOI: 10.1182/Blood.V106.11.1729.1729  0.326
2004 Ikezoe T, Hisatake Y, Takeuchi T, Ohtsuki Y, Yang Y, Said JW, Taguchi H, Koeffler HP. HIV-1 protease inhibitor, ritonavir: a potent inhibitor of CYP3A4, enhanced the anticancer effects of docetaxel in androgen-independent prostate cancer cells in vitro and in vivo. Cancer Research. 64: 7426-31. PMID 15492266 DOI: 10.1158/0008-5472.Can-03-2677  0.379
2004 Jones LC, Tefferi A, Idos GE, Kumagai T, Hofmann WK, Koeffler HP. RARbeta2 is a candidate tumor suppressor gene in myelofibrosis with myeloid metaplasia. Oncogene. 23: 7846-53. PMID 15361842 DOI: 10.1038/Sj.Onc.1207510  0.374
2004 Diederichs S, Bäumer N, Ji P, Metzelder SK, Idos GE, Cauvet T, Wang W, Möller M, Pierschalski S, Gromoll J, Schrader MG, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. The Journal of Biological Chemistry. 279: 33727-41. PMID 15159402 DOI: 10.1074/Jbc.M401708200  0.308
2004 Tong X, O'Kelly J, Xie D, Mori A, Lemp N, McKenna R, Miller CW, Koeffler HP. Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway. Oncogene. 23: 4847-55. PMID 15077166 DOI: 10.1038/Sj.Onc.1207628  0.383
2004 Chumakov AM, Kubota T, Walter S, Koeffler HP. Identification of murine and human XCP1 genes as C/EBP-epsilon-dependent members of FIZZ/Resistin gene family. Oncogene. 23: 3414-25. PMID 15064728 DOI: 10.1038/Sj.Onc.1207126  0.352
2004 Xie D, Yin D, Tong X, O'Kelly J, Mori A, Miller C, Black K, Gui D, Said JW, Koeffler HP. Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways. Cancer Research. 64: 1987-96. PMID 15026334 DOI: 10.1158/0008-5472.Can-03-0666  0.335
2004 Müller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Köhler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, et al. Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. Molecular and Cellular Biology. 24: 2890-904. PMID 15024077 DOI: 10.1128/Mcb.24.7.2890-2904.2004  0.319
2004 Ikezoe T, Yang Y, Saito T, Koeffler HP, Taguchi H. Proteasome inhibitor PS-341 down-regulates prostate-specific antigen (PSA) and induces growth arrest and apoptosis of androgen-dependent human prostate cancer LNCaP cells. Cancer Science. 95: 271-5. PMID 15016328 DOI: 10.1111/J.1349-7006.2004.Tb02215.X  0.371
2004 Kumagai T, Ikezoe T, Gui D, O'Kelly J, Tong XJ, Cohen FJ, Said JW, Koeffler HP. RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by arsenic trioxide. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 1508-20. PMID 14977855 DOI: 10.1158/1078-0432.Ccr-0476-03  0.323
2004 Yang Y, Ikezoe T, Saito T, Kobayashi M, Koeffler HP, Taguchi H. Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-Jun/AP-1 signaling. Cancer Science. 95: 176-80. PMID 14965369 DOI: 10.1111/J.1349-7006.2004.Tb03200.X  0.406
2004 Ikezoe T, Yang Y, Heber D, Taguchi H, Koeffler HP. PC-SPES: a potent inhibitor of nuclear factor-kappa B rescues mice from lipopolysaccharide-induced septic shock. Molecular Pharmacology. 64: 1521-9. PMID 14645683 DOI: 10.1124/Mol.64.6.1521  0.301
2004 Koeffler HP, O’Kelly J, Aslanian N. Clinical Trial of Paricalcitol in Myelodysplastic Syndrome. Blood. 104: 4720-4720. DOI: 10.1182/Blood.V104.11.4720.4720  0.302
2004 Muller CI, Kumagai T, O’Kelly J, Seeram N, Heber D, Koeffler HP. Anticancer Activity and Induction of Multinucleation in Hematologic Cell Lines Mediated by Ganoderma Lucidum. Blood. 104: 4499-4499. DOI: 10.1182/Blood.V104.11.4499.4499  0.356
2004 Kumagai T, Muller C, Desmond JC, Imai Y, Heber D, Koeffler HP. Scutellaria Baicalensis, a Herbal Medicine: Antitumor Activity Against Acute Lymphocytic Leukemia, Lymphoma and Myeloma in Vitro. Blood. 104: 4491-4491. DOI: 10.1182/Blood.V104.11.4491.4491  0.413
2004 Muller CI, Miller CW, Hofmann W, Kawamata N, Koeffler HP. Rare Mutations of the PIK3CA Gene in Hematologic Malignancies. Blood. 104: 4350-4350. DOI: 10.1182/Blood.V104.11.4350.4350  0.366
2004 Gery S, Stanosaki S, Ikezoe T, Hofmann WK, Gombart AF, Koeffler HP. C/EBPδ Modulates Cell Growth, Differentiation and Apoptosis of Myeloid Leukemia, Prostate and Breast Cancer Cells. Blood. 104: 4300-4300. DOI: 10.1182/Blood.V104.11.4300.4300  0.396
2004 Kawamata N, Koeffler HP. Mantle Cell Lymphoma: SAHA Blocks Akt/mTOR Pathway and Reduces Cyclin D1 Protein Levels by Affecting Translation. Blood. 104: 3293-3293. DOI: 10.1182/Blood.V104.11.3293.3293  0.389
2004 Desmond JC, Raynaud SD, Jones LC, Hofmann WK, Haferlach T, Koeffler HP. Identification of Epigenetically Silenced Tumor Suppressor Genes in Myeloid Disorders Leads to the Identification of α-Catenin as a Target Gene in 5q- Syndrome. Blood. 104: 2565-2565. DOI: 10.1182/Blood.V104.11.2565.2565  0.383
2004 Paz-Priel I, Cai DH, Wang D, Heckman CA, Gombart AF, Koeffler HP, Boxer LM, Friedman AD. C/EBPα and C/EBPα Myeloid Oncoproteins Inhibit Apoptosis and Induce Bcl-2 Via DNA-Binding Dependent and Independent Mechanisms. Blood. 104: 2561-2561. DOI: 10.1182/Blood.V104.11.2561.2561  0.378
2004 Ikezoe T, Yang Y, Bandobashi K, Sekiguchi N, Sakai S, Koeffler HP, Taguchi H. HIV-1 Protease Inhibitor Ritonavir Potentiates the Effect of 1,25-Dihydroxyvitamin D 3 to Induce Growth Arrest and Differentiation of Human Myeloid Leukemia Cells Via Inhibition of CYP24. Blood. 104: 2543-2543. DOI: 10.1182/Blood.V104.11.2543.2543  0.32
2004 Gombart AF, Kim O, Chen D, Borregaard N, Koeffler HP. The Human Cathelicidin Antimicrobial Peptide (CAMP) Gene Is a Direct Target of the Vitamin D Receptor and Is Strongly Upregulated in Myeloid Cells by 1,25(OH)2D3 Treatment. Blood. 104: 2380-2380. DOI: 10.1182/Blood.V104.11.2380.2380  0.38
2004 Gueller S, Komor M, Desmond JC, Ottmann OG, Hoelzer D, Koeffler HP, Hofmann W. Identification of Putative New Tumor Suppressor Genes in Highly Purified CD34+ Bone Marrow Cells from Patients with Myelodysplastic Syndromes. Blood. 104: 204-204. DOI: 10.1182/Blood.V104.11.204.204  0.405
2003 Zang C, Wächter M, Liu H, Posch MG, Fenner MH, Stadelmann C, Von Deimling A, Possinger K, Black KL, Koeffler HP, Elstner E. Ligands for PPARγ and RAR cause induction of growth inhibition and apoptosis in human glioblastomas Journal of Neuro-Oncology. 65: 107-118. PMID 14686729 DOI: 10.1023/B:Neon.0000003728.80052.A8  0.401
2003 Tavor S, Park DJ, Gery S, Vuong PT, Gombart AF, Koeffler HP. Restoration of C/EBPalpha expression in a BCR-ABL+ cell line induces terminal granulocytic differentiation. The Journal of Biological Chemistry. 278: 52651-9. PMID 14517214 DOI: 10.1074/Jbc.M307077200  0.415
2003 Gery S, Gombart AF, Fung YK, Koeffler HP. C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis. Blood. 103: 828-35. PMID 12947005 DOI: 10.1182/Blood-2003-01-0159  0.342
2003 Park DJ, Vuong PT, de Vos S, Douer D, Koeffler HP. Comparative analysis of genes regulated by PML/RAR alpha and PLZF/RAR alpha in response to retinoic acid using oligonucleotide arrays. Blood. 102: 3727-36. PMID 12893766 DOI: 10.1182/Blood-2003-02-0412  0.351
2003 de Vos S, Krug U, Hofmann WK, Pinkus GS, Swerdlow SH, Wachsman W, Grogan TM, Said JW, Koeffler HP. Cell cycle alterations in the blastoid variant of mantle cell lymphoma (MCL-BV) as detected by gene expression profiling of mantle cell lymphoma (MCL) and MCL-BV. Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B. 12: 35-43. PMID 12605034 DOI: 10.1097/00019606-200303000-00005  0.301
2003 Gombart AF, Kwok SH, Anderson KL, Yamaguchi Y, Torbett BE, Koeffler HP. Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1. Blood. 101: 3265-73. PMID 12515729 DOI: 10.1182/Blood-2002-04-1039  0.356
2003 Asou H, Gombart AF, Takeuchi S, Tanaka H, Tanioka M, Matsui H, Kimura A, Inaba T, Koeffler HP. Establishment of the acute myeloid leukemia cell line Kasumi-6 from a patient with a dominant-negative mutation in the DNA-binding region of the C/EBPalpha gene. Genes, Chromosomes & Cancer. 36: 167-74. PMID 12508245 DOI: 10.1002/Gcc.10161  0.39
2003 Yin D, Xie D, Hofmann WK, Zhang W, Asotra K, Wong R, Black KL, Koeffler HP. DNA repair gene O6-methylguanine-DNA methyltransferase: Promoter hypermethylation associated with decreased expression and G:C to A:T mutations of p53 in brain tumors Molecular Carcinogenesis. 36: 23-31. PMID 12503076 DOI: 10.1002/Mc.10094  0.33
2003 Hofmann WK, Koeffler HP. Important features of myelodysplastic syndrome. International Journal of Hematology. 222-7. PMID 12430929 DOI: 10.1007/Bf03165121  0.35
2003 Müller-Tidow C, Readhead C, Cohen AH, Asotra K, Idos G, Diederichs S, Cauvet T, Yang R, Berdel WE, Serve H, Koeffler HP. Successive increases in human cyclin A1 promoter activity during spermatogenesis in transgenic mice. International Journal of Molecular Medicine. 11: 311-315. DOI: 10.3892/Ijmm.11.3.311  0.319
2002 Yin D, Xie D, Hofmann WK, Miller CW, Black KL, Koeffler HP. Methylation, expression, and mutation analysis of the cell cycle control genes in human brain tumors. Oncogene. 21: 8372-8. PMID 12447702 DOI: 10.1038/Sj.Onc.1206031  0.329
2002 Hofmann WK, de Vos S, Komor M, Hoelzer D, Wachsman W, Koeffler HP. Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow. Blood. 100: 3553-60. PMID 12411319 DOI: 10.1182/Blood.V100.10.3553  0.324
2002 Gery S, Sawyers CL, Agus DB, Said JW, Koeffler HP. TMEFF2 is an androgen-regulated gene exhibiting antiproliferative effects in prostate cancer cells. Oncogene. 21: 4739-46. PMID 12101412 DOI: 10.1038/Sj.Onc.1205142  0.355
2002 Williamson EA, Dadmanesh F, Koeffler HP. BRCA1 transactivates the cyclin-dependent kinase inhibitor p27(Kip1). Oncogene. 21: 3199-206. PMID 12082635 DOI: 10.1038/Sj.Onc.1205461  0.382
2002 Krug U, Ganser A, Koeffler HP. Tumor suppressor genes in normal and malignant hematopoiesis. Oncogene. 21: 3475-95. PMID 12032783 DOI: 10.1038/Sj.Onc.1205322  0.368
2002 O'Kelly J, Hisatake J, Hisatake Y, Bishop J, Norman A, Koeffler HP. Normal myelopoiesis but abnormal T lymphocyte responses in vitamin D receptor knockout mice. The Journal of Clinical Investigation. 109: 1091-9. PMID 11956247 DOI: 10.1172/Jci12392  0.321
2002 Vegesna V, Takeuchi S, Hofmann WK, Ikezoe T, Tavor S, Krug U, Fermin AC, Heaney A, Miller CW, Koeffler HP. C/EBP-beta, C/EBP-delta, PU.1, AML1 genes: mutational analysis in 381 samples of hematopoietic and solid malignancies. Leukemia Research. 26: 451-7. PMID 11916518 DOI: 10.1016/S0145-2126(01)00150-3  0.356
2002 Jones LC, Lin ML, Chen SS, Krug U, Hofmann WK, Lee S, Lee YH, Koeffler HP. Expression of C/EBPbeta from the C/ebpalpha gene locus is sufficient for normal hematopoiesis in vivo. Blood. 99: 2032-6. PMID 11877276 DOI: 10.1182/Blood.V99.6.2032  0.337
2002 Hofmann WK, Jones LC, Lemp NA, de Vos S, Gschaidmeier H, Hoelzer D, Ottmann OG, Koeffler HP. Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation. Blood. 99: 1860-2. PMID 11861307 DOI: 10.1182/Blood.V99.5.1860  0.319
2002 Tavor S, Vuong PT, Park DJ, Gombart AF, Cohen AH, Koeffler HP. Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice. Blood. 99: 1794-801. PMID 11861297 DOI: 10.1182/Blood.V99.5.1794  0.316
2002 Hofmann WK, de Vos S, Elashoff D, Gschaidmeier H, Hoelzer D, Koeffler HP, Ottmann OG. Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study. Lancet (London, England). 359: 481-6. PMID 11853794 DOI: 10.1016/S0140-6736(02)07678-X  0.312
2002 Gombart AF, Hofmann WK, Kawano S, Takeuchi S, Krug U, Kwok SH, Larsen RJ, Asou H, Miller CW, Hoelzer D, Koeffler HP. Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias. Blood. 99: 1332-40. PMID 11830484 DOI: 10.1182/Blood.V99.4.1332  0.386
2002 Gombart AF, Koeffler HP. Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon). Current Opinion in Hematology. 9: 36-42. PMID 11753076 DOI: 10.1097/00062752-200201000-00007  0.346
2002 Miller CW, Ikezoe T, Krug U, Hofmann WK, Tavor S, Vegesna V, Tsukasaki K, Takeuchi S, Koeffler HP. Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors. Genes, Chromosomes & Cancer. 33: 17-21. PMID 11746983 DOI: 10.1002/Gcc.1207  0.372
2002 Ikezoe T, Chen SS, Heber D, Taguchi H, Koeffler HP. Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest. The Prostate. 49: 285-92. PMID 11746275 DOI: 10.1002/Pros.10024  0.317
2002 Xie D, Jauch A, Miller CW, Bartram CR, Koeffler HP. Discovery of over-expressed genes and genetic alterations in breast cancer cells using a combination of suppression subtractive hybridization, multiplex FISH and comparative genomic hybridization International Journal of Oncology. 21: 499-507. DOI: 10.3892/Ijo.21.3.499  0.351
2002 Park WH, Seol JG, Kim ES, Binderup L, Koeffler HP, Kim BK, Lee YY. The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-β1 in NCI-H929 multiple myeloma cells International Journal of Oncology. 20: 533-542. DOI: 10.3892/Ijo.20.3.533  0.324
2002 Tong X, Kawabata H, Koeffler HP. Iron deficiency can upregulate expression of transferrin receptor at both the mRNA and protein level British Journal of Haematology. 116: 458-464. DOI: 10.1046/J.1365-2141.2002.03289.X  0.323
2001 Tavor S, Takeuchi S, Tsukasaki K, Miller CW, Hofmann WK, Ikezoe T, Said JW, Koeffler HP. Analysis of the CHK2 gene in lymphoid malignancies. Leukemia & Lymphoma. 42: 517-20. PMID 11699418 DOI: 10.3109/10428190109064610  0.397
2001 Kawabata H, Nakamaki T, Ikonomi P, Smith RD, Germain RS, Koeffler HP. Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells. Blood. 98: 2714-9. PMID 11675342 DOI: 10.1182/Blood.V98.9.2714  0.369
2001 Kubota T, Hirama T, Verbeek W, Kawano S, Chih DY, Chumakov AM, Taguchi H, Koeffler HP. DNase I hypersensitivity analysis of the human CCAAT enhancer binding protein ε (C/EBPε) gene Leukemia Research. 25: 981-995. PMID 11597733 DOI: 10.1016/S0145-2126(01)00065-0  0.385
2001 Kawabata H, Germain RS, Ikezoe T, Tong X, Green EM, Gombart AF, Koeffler HP. Regulation of expression of murine transferrin receptor 2. Blood. 98: 1949-54. PMID 11535534 DOI: 10.1182/Blood.V98.6.1949  0.334
2001 Hofmann WK, Takeuchi S, Xie D, Miller CW, Hoelzer D, Koeffler HP. Frequent loss of heterozygosity in the region of D1S450 at 1p36.2 in myelodysplastic syndromes. Leukemia Research. 25: 855-8. PMID 11532517 DOI: 10.1016/S0145-2126(01)00037-6  0.339
2001 Hofmann WK, de Vos S, Tsukasaki K, Wachsman W, Pinkus GS, Said JW, Koeffler HP. Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray. Blood. 98: 787-94. PMID 11468180 DOI: 10.1182/Blood.V98.3.787  0.364
2001 Tsukasaki K, Miller CW, Greenspun E, Eshaghian S, Kawabata H, Fujimoto T, Tomonaga M, Sawyers C, Said JW, Koeffler HP. Mutations in the mitotic check point gene, MAD1L1, in human cancers. Oncogene. 20: 3301-5. PMID 11423979 DOI: 10.1038/Sj.Onc.1204421  0.409
2001 Tsukasaki K, Krebs J, Nagai K, Tomonaga M, Koeffler HP, Bartram CR, Jauch A. Comparative genomic hybridization analysis in adult T-cell leukemia/lymphoma: correlation with clinical course. Blood. 97: 3875-81. PMID 11389029 DOI: 10.1182/Blood.V97.12.3875  0.301
2001 Gombart AF, Shiohara M, Kwok SH, Agematsu K, Komiyama A, Koeffler HP. Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein--epsilon. Blood. 97: 2561-7. PMID 11313242 DOI: 10.1182/Blood.V97.9.2561  0.365
2001 Hisatake J, O'Kelly J, Uskokovic MR, Tomoyasu S, Koeffler HP. Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells. Blood. 97: 2427-33. PMID 11290607 DOI: 10.1182/Blood.V97.8.2427  0.399
2001 Tang J, Koeffler HP. Structural and Functional Studies of CCAAT/Enhancer-binding Protein ε Journal of Biological Chemistry. 276: 17739-17746. PMID 11278928 DOI: 10.1074/Jbc.M011546200  0.319
2001 Hofmann WK, Miller CW, Tsukasaki K, Tavor S, Ikezoe T, Hoelzer D, Takeuchi S, Koeffler HP. Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias. Leukemia Research. 25: 333-8. PMID 11248330 DOI: 10.1016/S0145-2126(00)00130-2  0.38
2001 Scholz I, Popp S, Granzow M, Schoell B, Holtgreve-Grez H, Takeuchi S, Schrappe M, Harbott J, Teigler-Schlegel A, Zimmermann M, Fischer C, Koeffler HP, Bartram CR, Jauch A. Comparative genomic hybridization in childhood acute lymphoblastic leukemia: correlation with interphase cytogenetics and loss of heterozygosity analysis. Cancer Genetics and Cytogenetics. 124: 89-97. PMID 11172898 DOI: 10.1016/S0165-4608(00)00330-7  0.304
2001 Koeffler HP. Welcome to the era of interconnecting pathways Blood. 98: 895-895. DOI: 10.1182/Blood.V98.4.895  0.352
2000 Campbell MJ, Gombart AF, Kwok SH, Park S, Koeffler HP. The anti-proliferative effects of 1alpha,25(OH)2D3 on breast and prostate cancer cells are associated with induction of BRCA1 gene expression. Oncogene. 19: 5091-7. PMID 11042697 DOI: 10.1038/Sj.Onc.1203888  0.36
2000 Park WH, Seol JG, Kim ES, Hyun JM, Jung CW, Lee CC, Binderup L, Koeffler HP, Kim BK, Lee YY. Induction of apoptosis by vitamin D3 analogue EB1089 in NCI-H929 myeloma cells via activation of caspase 3 and p38 MAP kinase. British Journal of Haematology. 109: 576-83. PMID 10886207 DOI: 10.1046/J.1365-2141.2000.02046.X  0.372
2000 Mehta RG, Williamson E, Patel MK, Koeffler HP. A Ligand of Peroxisome Proliferator-Activated Receptor γ, Retinoids, and Prevention of Preneoplastic Mammary Lesions Journal of the National Cancer Institute. 92: 418-423. PMID 10699072 DOI: 10.1093/Jnci/92.5.418  0.304
2000 Park WH, Seol JG, Kim ES, Jung CW, Lee CC, Binderup L, Koeffler HP, Kim BK, Lee YY. Cell cycle arrest induced by the vitamin D(3) analog EB1089 in NCI-H929 myeloma cells is associated with induction of the cyclin-dependent kinase inhibitor p27. Experimental Cell Research. 254: 279-86. PMID 10640426 DOI: 10.1006/Excr.1999.4735  0.397
2000 Kubota T, Hisatake J, Hisatake Y, Said JW, Chen SS, Holden S, Taguchi H, Koeffler HP. PC-SPES: a unique inhibitor of proliferation of prostate cancer cells in vitro and in vivo . The Prostate. 42: 163-71. PMID 10639186 DOI: 10.1002/(Sici)1097-0045(20000215)42:3<163::Aid-Pros1>3.0.Co;2-W  0.317
2000 Kubota T, Kawano S, Chih DY, Hisatake Y, Chumakov AM, Taguchi H, Koeffler HP. Representational difference analysis using myeloid cells from C/EBPε deletional mice Blood. 96: 3953-3957. DOI: 10.1182/Blood.V96.12.3953  0.366
2000 Müller C, Yang R, Park DJ, Serve H, Berdel WE, Koeffler HP. The aberrant fusion proteins PML-RARα and PLZF-RARα contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia Blood. 96: 3894-3899. DOI: 10.1182/Blood.V96.12.3894.H8003894_3894_3899  0.314
2000 Ikezoe T, Daar ES, Hisatake J, Taguchi H, Koeffler HP. HIV-1 protease inhibitors decrease proliferation and induce differentiation of human myelocytic leukemia cells Blood. 96: 3553-3559. DOI: 10.1182/Blood.V96.10.3553.H8003553_3553_3559  0.346
2000 Komatsu N, Takeuchi S, Ikezoe T, Tasaka T, Hatta Y, Machida H, Williamson IK, Bartram CR, Koeffler HP, Taguchi H. Mutations of the E2F4 gene in hematological malignancies having microsatellite instability Blood. 95: 1509-1510. DOI: 10.1182/Blood.V95.4.1509.004K33_1509_1510  0.357
2000 Tidow N, Chen X, Müller C, Kawano S, Gombart AF, Fischel-Ghodsian N, Koeffler HP. Hematopoietic-specific expression of MEFV, the gene mutated in familial Mediterranean fever, and subcellular localization of its corresponding protein, pyrin Blood. 95: 1451-1455. DOI: 10.1182/Blood.V95.4.1451.004K52_1451_1455  0.398
1999 Hirama T, Miller CW, Koeffler HP. Translocon-associated protein α transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation Febs Letters. 455: 223-227. PMID 10437777 DOI: 10.1016/S0014-5793(99)00885-6  0.348
1999 Park DJ, Chumakov AM, Vuong PT, Chih DY, Gombart AF, Miller WH, Koeffler HP. CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment. The Journal of Clinical Investigation. 103: 1399-408. PMID 10330422 DOI: 10.1172/Jci2887  0.384
1999 Koshizuka K, Koike M, Asou H, Cho SK, Stephen T, Rude RK, Binderup L, Uskokovic M, Koeffler HP. Combined effect of vitamin D3 analogs and paclitaxel on the growth of MCF-7 breast cancer cells in vivo Breast Cancer Research and Treatment. 53: 113-120. PMID 10326788 DOI: 10.1023/A:1006123819675  0.311
1999 Verbeek W, Lekstrom-Himes J, Park DJ, Dang PM, Vuong PT, Kawano S, Babior BM, Xanthopoulos K, Koeffler HP. Myeloid Transcription Factor C/EBPɛ Is Involved in the Positive Regulation of Lactoferrin Gene Expression in Neutrophils Blood. 94: 3141-3150. DOI: 10.1182/Blood.V94.9.3141.421K41_3141_3150  0.35
1999 Kawano S, Miller CW, Gombart AF, Bartram CR, Matsuo Y, Asou H, Sakashita A, Said J, Tatsumi E, Koeffler HP. Loss of p73 Gene Expression in Leukemias/Lymphomas Due to Hypermethylation Blood. 94: 1113-1120. DOI: 10.1182/Blood.V94.3.1113.415K33_1113_1120  0.394
1999 Muto A, Kizaki M, Yamato K, Kawai Y, Kamata-Matsushita M, Ueno H, Ohguchi M, Nishihara T, Koeffler HP, Ikeda Y. 1,25-Dihydroxyvitamin D3 Induces Differentiation of a Retinoic Acid–Resistant Acute Promyelocytic Leukemia Cell Line (UF-1) Associated With Expression of p21WAF1/CIP1 and p27KIP1 Blood. 93: 2225-2233. DOI: 10.1182/Blood.V93.7.2225.407A05_2225_2233  0.362
1999 Hatta Y, Yamada Y, Tomonaga M, Miyoshi I, Said JW, Koeffler HP. Detailed Deletion Mapping of the Long Arm of Chromosome 6 in Adult T-Cell Leukemia Blood. 93: 613-616. DOI: 10.1182/Blood.V93.2.613  0.308
1998 Campbell MJ, Park S, Uskokovic MR, Dawson MI, Koeffler HP. Expression of Retinoic Acid Receptor-β Sensitizes Prostate Cancer Cells to Growth Inhibition Mediated by Combinations of Retinoids and a 19-nor Hexafluoride Vitamin D3 Analog. Endocrinology. 139: 1972-1980. PMID 28200527 DOI: 10.1210/Endo.139.4.5943  0.333
1998 Takeuchi S, Koike M, Park S, Seriu T, Bartram CR, Taub HE, Williamson IK, Grewal J, Taguchi H, Koeffler HP. The ATM gene and susceptibility to childhood T-cell acute lymphoblastic leukaemia. British Journal of Haematology. 103: 536-8. PMID 9827931 DOI: 10.1046/J.1365-2141.1998.00993.X  0.303
1998 Ueno H, Kizaki M, Matsushita H, Muto A, Yamato K, Nishihara T, Hida T, Yoshimura H, Koeffler HP, Ikeda Y. A novel retinoic acid receptor (RAR)-selective antagonist inhibits differentiation and apoptosis of HL-60 cells: implications of RARalpha-mediated signals in myeloid leukemic cells. Leukemia Research. 22: 517-25. PMID 9678718 DOI: 10.1016/S0145-2126(98)00026-5  0.367
1998 Williamson EA, Xu HN, Gombart AF, Verbeek W, Chumakov AM, Friedman AD, Koeffler HP. Identification of transcriptional activation and repression domains in human CCAAT/enhancer-binding protein epsilon. The Journal of Biological Chemistry. 273: 14796-804. PMID 9614080 DOI: 10.1074/Jbc.273.24.14796  0.34
1998 Hatta Y, Yamada Y, Tomonaga M, Miyoshi I, Said JW, Koeffler HP. Microsatellite instability in adult T-cell leukaemia. British Journal of Haematology. 101: 341-4. PMID 9609532 DOI: 10.1046/J.1365-2141.1998.00710.X  0.302
1998 Koike M, Chumakov AM, Takeuchi S, Tasaka T, Yang R, Nakamaki T, Tsuruoka N, Koeffler HP. C/EBP-epsilon: chromosomal mapping and mutational analysis of the gene in leukemia and preleukemia. Leukemia Research. 21: 833-9. PMID 9393598 DOI: 10.1016/S0145-2126(97)00072-6  0.376
1998 Mori N, Morosetti R, Spira S, Lee S, Ben-Yehuda D, Schiller G, Landolfi R, Mizoguchi H, Koeffler HP. Chromosome Band 1p36 Contains a Putative Tumor Suppressor Gene Important in the Evolution of Chronic Myelocytic Leukemia Blood. 92: 3405-3409. DOI: 10.1182/Blood.V92.9.3405.421K44_3405_3409  0.348
1998 Hatta Y, Yamada Y, Tomonaga M, Said JW, Miyosi I, Koeffler HP. Allelotype Analysis of Adult T-Cell Leukemia Blood. 92: 2113-2117. DOI: 10.1182/Blood.V92.6.2113  0.323
1997 Shiohara M, Gombart AF, Berman JD, Koike K, Komiyama A, Koeffler HP. Cytostatic effect of TNFalpha on cancer cells is independent of p21WAF1. Oncogene. 15: 1605-9. PMID 9380413 DOI: 10.1038/sj.onc.1201315  0.308
1997 Lee YY, Kang SH, Seo JY, Jung CW, Lee KU, Choe KJ, Kim BK, Kim NK, Koeffler HP, Bang YJ. Alterations of p16INK4A and p15INK4B genes in gastric carcinomas. Cancer. 80: 1889-96. PMID 9366289 DOI: 10.1002/(Sici)1097-0142(19971115)80:10<1889::Aid-Cncr3>3.0.Co;2-J  0.318
1997 Verbeek W, Gombart AF, Shiohara M, Campbell M, Koeffler HP. Vitamin D receptor: no evidence for allele-specific mRNA stability in cells which are heterozygous for the Taq I restriction enzyme polymorphism. Biochemical and Biophysical Research Communications. 238: 77-80. PMID 9299455 DOI: 10.1006/Bbrc.1997.7239  0.308
1997 Miller CW, Morosetti R, Campbell MJ, Mendoza S, Koeffler HP. Integrity of the 1,25-dihydroxyvitamin D3 receptor in bone, lung, and other cancers. Molecular Carcinogenesis. 19: 254-7. PMID 9290702 DOI: 10.1002/(Sici)1098-2744(199708)19:4<254::Aid-Mc6>3.0.Co;2-C  0.393
1997 Campbell MJ, Reddy GS, Koeffler HP. Vitamin D3 analogs and their 24-oxo metabolites equally inhibit clonal proliferation of a variety of cancer cells but have differing molecular effects. Journal of Cellular Biochemistry. 66: 413-25. PMID 9257197 DOI: 10.1002/(Sici)1097-4644(19970901)66:3<413::Aid-Jcb13>3.0.Co;2-F  0.323
1997 Shiohara M, Koike K, Komiyama A, Koeffler HP. p21WAF1 mutations and human malignancies. Leukemia & Lymphoma. 26: 35-41. PMID 9250785 DOI: 10.3109/10428199709109155  0.329
1997 Hatta Y, Yamada Y, Tomonaga M, Koeffler HP. Extensive analysis of the retinoblastoma gene in adult T cell leukemia/lymphoma (ATL). Leukemia. 11: 984-9. PMID 9204979 DOI: 10.1038/sj.leu.2400686  0.312
1997 Koike M, Takeuchi S, Yokota J, Park S, Hatta Y, Miller CW, Tsuruoka N, Koeffler HP. Frequent loss of heterozygosity in the region of the D7S523 locus in advanced ovarian cancer. Genes, Chromosomes & Cancer. 19: 1-5. PMID 9135988 DOI: 10.1002/(Sici)1098-2264(199705)19:1<1::Aid-Gcc1>3.0.Co;2-3  0.307
1997 Nakamaki T, Bartram C, Seriu T, Kahan J, Fukuchi K, Tsuruoka N, Janssen JWG, Miller CW, Koeffler HP. Molecular analysis of the cyclin-dependent kinase inhibitor genes, p15, p16, p18 and p19 in the myelodysplastic syndromes Leukemia Research. 21: 235-240. PMID 9111168 DOI: 10.1016/S0145-2126(96)00115-4  0.345
1997 Kawamata N, Seriu T, Bartram CR, Koeffler HP. Molecular analysis of the secretory phospholipase A2 gene, a candidate of Mom1 gene, in neuroblastomas. Cancer Letters. 111: 71-5. PMID 9022130 DOI: 10.1016/S0304-3835(96)04503-X  0.32
1997 Tasaka T, Berenson J, Vescio R, Hirama T, Miller CW, Nagai M, Takahara J, Koeffler HP. Analysis of the p16INK4A, p15INK4B and p18INK4C genes in multiple myeloma. British Journal of Haematology. 96: 98-102. PMID 9012694 DOI: 10.1046/J.1365-2141.1997.8552482.X  0.329
1997 Mori N, Morosetti R, Lee S, Spira S, Ben-Yehuda D, Schiller G, Landolfi R, Mizoguchi H, Koeffler HP. Allelotype Analysis in the Evolution of Chronic Myelocytic Leukemia Blood. 90: 2010-2014. DOI: 10.1182/Blood.V90.5.2010  0.302
1997 Said JW, Rettig MR, Heppner K, Vescio RA, Schiller G, Ma HJ, Belson D, Savage A, Shintaku IP, Koeffler HP, Asou H, Pinkus G, Pinkus J, Schrage M, Green E, et al. Localization of Kaposi's Sarcoma–Associated Herpesvirus in Bone Marrow Biopsy Samples From Patients With Multiple Myeloma Blood. 90: 4278-4282. DOI: 10.1182/Blood.V90.11.4278.4278_4278_4282  0.305
1996 Paquette RL, Hsu NC, Koeffler HP. Analysis of c-kit gene integrity in aplastic anemia. Blood Cells, Molecules & Diseases. 22: 159-68. PMID 8931956 DOI: 10.1006/Bcmd.1996.0023  0.358
1996 Kawamata N, Park D, Wilczynski S, Yokota J, Koeffler HP. Point mutations of the Mxi1 gene are rare in prostate cancers Prostate. 29: 191-193. PMID 8827088 DOI: 10.1002/1097-0045(199609)29:3<191::Aid-Pros2990290305>3.0.Co;2-1  0.362
1996 Kawamata N, Seriu T, Koeffler HP, Bartram CR. Molecular analysis of the cyclin-dependent kinase inhibitor family: p16(CDKN2/MTS1/INK4A), p18(INK4C) and p27(Kip1) genes in neuroblastomas. Cancer. 77: 570-5. PMID 8630967 DOI: 10.1002/(Sici)1097-0142(19960201)77:3<570::Aid-Cncr21>3.0.Co;2-0  0.352
1996 Shiohara M, Akashi M, Gombart AF, Yang R, Koeffler HP. Tumor necrosis factor alpha: posttranscriptional stabilization of WAF1 mRNA in p53-deficient human leukemic cells. Journal of Cellular Physiology. 166: 568-76. PMID 8600160 DOI: 10.1002/(Sici)1097-4652(199603)166:3<568::Aid-Jcp11>3.0.Co;2-3  0.346
1996 de Vos S, Miller CW, Takeuchi S, Gombart AF, Cho SK, Koeffler HP. Alterations of CDKN2 (p16) in non-small cell lung cancer. Genes, Chromosomes & Cancer. 14: 164-70. PMID 8589032 DOI: 10.1002/Gcc.2870140303  0.372
1995 Ishiguro A, Spirin K, Shiohara M, Tobler A, Norton JD, Rigolet M, Shimbo T, Koeffler HP. Expression of Id2 and Id3 mRNA in human lymphocytes Leukemia Research. 19: 989-996. PMID 8632670 DOI: 10.1016/0145-2126(95)00084-4  0.351
1995 Lee YY, Kim WS, Jung TJ, Choi IY, Bang Y, Jung CW, Park S, Kim BK, Kim NK, Yoon WJ, Cho KS, Koeffler HP. Analysis of mutations of neurofibromatosis type 1 gene and N‐ras gene in acute myelogenous leukemia Stem Cells. 13: 556-563. PMID 8528106 DOI: 10.1002/Stem.5530130514  0.307
1995 Schwaller J, Koeffler HP, Niklaus G, Loetscher P, Nagel S, Fey MF, Tobler A. Posttranscriptional Stabilization Underlies p53-independent Induction of p21WAF1/CIP1/SDI1 in Differentiating Human Leukemic Cells Journal of Clinical Investigation. 95: 973-979. PMID 7883998 DOI: 10.1172/JCI117806  0.309
1995 Sakashita A, Curnutte JT, Koeffler HP. Myeloid haemopoietic cells of patients with chronic granulomatous disease are relatively resistant to TNF. British Journal of Haematology. 88: 31-8. PMID 7803254 DOI: 10.1111/J.1365-2141.1994.Tb04973.X  0.362
1995 Akashi M, Hachiya M, Osawa Y, Spirin K, Suzuki G, Koeffler HP. Irradiation induces WAF1 expression through a p53-independent pathway in KG-1 cells. The Journal of Biological Chemistry. 270: 19181-7. PMID 7642586 DOI: 10.1074/Jbc.270.32.19181  0.393
1995 Ikezoe T, Miyagi T, Kubota T, Taguchi T, Ohtsuki Y, Miyake K, Inokuchi K, Nomura T, Koeffler HP, Miyoshi I. Inactivation of the DCC tumor suppressor gene in a B-cell lymphoma cell line with the alteration of chromosome 18. American Journal of Hematology. 50: 124-32. PMID 7572991 DOI: 10.1002/Ajh.2830500209  0.403
1994 Hachiya M, Suzuki G, Koeffler HP, Akashi M. Irradiation increases expression of GM-CSF in human fibroblasts by transcriptional and post-transcriptional regulation. Experimental Cell Research. 214: 343-50. PMID 8082737 DOI: 10.1006/Excr.1994.1266  0.324
1993 Chumakov A, Koeffler HP. Specific interaction between adenoviral 55-kDa E1B protein and in vivo produced p53 fusion proteins. Gene. 131: 231-6. PMID 8406015 DOI: 10.1016/0378-1119(93)90298-H  0.314
1991 Miyagi T, Akashi M, Yamato K, Miyoshi I, Koeffler HP. D-factor: modulation of expression in fibroblasts. Leukemia Research. 15: 441-51. PMID 1713634 DOI: 10.1016/0145-2126(91)90054-W  0.343
1990 Sun G, Koeffler HP, Gale RP, Sparkes RS, Schreck RR. Use of conditioned media in cell culture can mask cytogenetic abnormalities in acute leukemia Cancer Genetics and Cytogenetics. 46: 107-113. PMID 2331674 DOI: 10.1016/0165-4608(90)90016-4  0.334
1990 Kizaki M, Koeffler HP, Lin CW, Miller CW. Expression of retinoic acid receptor mRNA in hematopoietic cells Leukemia Research. 14: 645-655. PMID 2167405 DOI: 10.1016/0145-2126(90)90020-A  0.319
1988 Tobler A, Miller CW, Johnson KR, Selsted ME, Rovera G, Koeffler HP. Regulation of gene expression of myeloperoxidase during myeloid differentiation Journal of Cellular Physiology. 136: 215-225. PMID 2842344 DOI: 10.1002/Jcp.1041360203  0.364
1986 Munker R, Gasson J, Ogawa M, Koeffler HP. Recombinant human TNF induces production of granulocyte-monocyte colony-stimulating factor. Nature. 323: 79-82. PMID 3489188 DOI: 10.1038/323079A0  0.346
1986 Miller C, Koeffler HP. The molecular biology of differentiation and proliferation using human myelogenous leukemia cells Bioessays. 5: 18-21. DOI: 10.1002/Bies.950050106  0.399
1985 Amatruda TT, Sidell N, Ranyard J, Koeffler HP. Retinoic acid treatment of human neuroblastoma cells is associated with decreased N-myc expression. Biochemical and Biophysical Research Communications. 126: 1189-95. PMID 3977910 DOI: 10.1016/0006-291X(85)90311-0  0.361
1985 Koeffler HP, Yelton L, Prokocimer M, Hirji K. Study of differentiation of fresh myelogenous leukemic cells by compounds that induce a human promyelocytic leukemic line (HL-60) to differentiate. Leukemia Research. 9: 73-81. PMID 3857407 DOI: 10.1016/0145-2126(85)90022-0  0.349
1984 Carlson J, Dorey F, Cragoe E, Koeffler HP. Amiloride potentiation of differentiation of human promyelocytic cell line HL-60. Journal of the National Cancer Institute. 72: 13-7. PMID 6582292 DOI: 10.1093/Jnci/72.1.13  0.335
1981 Territo MC, Koeffler HP. Induction by phorbol esters of macrophage differentiation in human leukaemia cell lines does not require cell division. British Journal of Haematology. 47: 479-83. PMID 7459283 DOI: 10.1111/J.1365-2141.1981.Tb02816.X  0.347
1981 Koeffler HP, Yen H, Lowe L. An in vitro model for acute myelogenous leukemia chemotherapy Cancer. 48: 1958-1963. PMID 6945901 DOI: 10.1002/1097-0142(19811101)48:9<1958::Aid-Cncr2820480908>3.0.Co;2-C  0.335
1980 Niskanen E, Koeffler HP, Golde DW, Cline MJ. Responsiveness of a human myelogenous leukemia cell line (KG-1) to humoral factors in vivo. Leukemia Research. 4: 203-8. PMID 6931958 DOI: 10.1016/0145-2126(80)90079-X  0.351
1979 Koeffler HP, Cline MJ, Golde DW. Splenic irradiation in myelofibrosis: effect on circulating myeloid progenitor cells. British Journal of Haematology. 43: 69-77. PMID 508623 DOI: 10.1111/J.1365-2141.1979.Tb03721.X  0.301
1979 Koeffler HP, Golde DW. 5-fluorocytosine: inhibition of hematopoiesis in vitro and reversal of inhibition by uracil. The Journal of Infectious Diseases. 139: 438-43. PMID 438544 DOI: 10.1093/Infdis/139.4.438  0.328
1978 Koeffler HP, Golde DW. Amphotericin inhibition of hematopoiesis in vitro. American Journal of Hematology. 3: 57-62. PMID 602944 DOI: 10.1002/Ajh.2830030107  0.331
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