C.A Simmons - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Biomedical Engineering

101 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Fitzsimmons REB, Ireland RG, Zhong A, Soos A, Simmons CA. Assessment of fibrin-collagen co-gels for generating microvesselsusing endothelial cell-lined microfluidics and multipotent stromal cell (MSC)-induced capillary morphogenesis. Biomedical Materials (Bristol, England). PMID 33086195 DOI: 10.1088/1748-605X/abc38f  0.314
2020 Ngai D, Lino M, Rothenberg KE, Simmons CA, Fernandez-Gonzalez R, Bendeck MP. DDR1 (Discoidin Domain Receptor-1)-RhoA Axis Senses Matrix Stiffness to Promote Vascular Calcification. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120314697. PMID 32493168 DOI: 10.1161/Atvbaha.120.314697  0.377
2020 Moyle LA, Cheng RY, Liu H, Davoudi S, Ferreira SA, Nissar AA, Sun Y, Gentleman E, Simmons CA, Gilbert PM. Three-dimensional niche stiffness synergizes with Wnt7a to modulate the extent of satellite cell symmetric self-renewal divisions. Molecular Biology of the Cell. mbcE20010078. PMID 32491970 DOI: 10.1091/Mbc.E20-01-0078  0.368
2020 Ireland RG, Kibschull M, Audet J, Ezzo M, Hinz B, Lye SJ, Simmons CA. Combinatorial extracellular matrix microarray identifies novel bioengineered substrates for xeno-free culture of human pluripotent stem cells. Biomaterials. 248: 120017. PMID 32283392 DOI: 10.1016/J.Biomaterials.2020.120017  0.363
2019 Zhang X, Simmons CA, Santerre JP. Paracrine signalling of monocytes enables desirable extracellular matrix accumulation and temporally appropriate phenotype of vascular smooth muscle cell-like cells derived from adipose stromal cells. Acta Biomaterialia. PMID 31821896 DOI: 10.1016/J.Actbio.2019.12.006  0.434
2019 Shridhar A, Lam AYL, Sun Y, Simmons CA, Gillies ER, Flynn LE. Culture on tissue-specific Coatings Derived from α-amylase-digested Decellularized Adipose Tissue Enhances the Proliferation and Adipogenic Differentiation of Human adipose-derived Stromal Cells. Biotechnology Journal. e1900118. PMID 31657515 DOI: 10.1002/Biot.201900118  0.354
2019 Wong JF, Mohan MD, Young EWK, Simmons CA. Integrated electrochemical measurement of endothelial permeability in a 3D hydrogel-based microfluidic vascular model. Biosensors & Bioelectronics. 147: 111757. PMID 31654819 DOI: 10.1016/J.Bios.2019.111757  0.352
2019 Beca B, Sun Y, Wong E, Moraes C, Simmons CA. Dynamic bioreactors with integrated microfabricated devices for mechanobiological screening. Tissue Engineering. Part C, Methods. PMID 31337285 DOI: 10.1089/Ten.Tec.2019.0121  0.417
2019 Wong JF, Simmons CA. Microfluidic assay for the on-chip electrochemical measurement of cell monolayer permeability. Lab On a Chip. PMID 30778462 DOI: 10.1039/C8Lc01321G  0.346
2018 Zhang X, Battiston KG, Simmons CA, Santerre JP. Differential Regulation of Extracellular Matrix Components Using Different Vitamin C Derivatives in Mono- and Coculture Systems. Acs Biomaterials Science & Engineering. 4: 3768-3778. PMID 33429598 DOI: 10.1021/acsbiomaterials.7b00389  0.317
2018 Zhang X, Simmons CA, Santerre JP. Alterations of MEK1/2-ERK1/2, IFNγ and Smad2/3 associated Signalling pathways during cryopreservation of ASCs affect their differentiation towards VSMC-like cells. Stem Cell Research. 32: 115-125. PMID 30273905 DOI: 10.1016/J.Scr.2018.09.005  0.395
2018 Fitzsimmons REB, Mazurek MS, Soos A, Simmons CA. Mesenchymal Stromal/Stem Cells in Regenerative Medicine and Tissue Engineering. Stem Cells International. 2018: 8031718. PMID 30210552 DOI: 10.1155/2018/8031718  0.369
2018 Wang L, Dou W, Malhi M, Zhu M, Liu H, Plakhotnik J, Xu Z, Zhao Q, Chen J, Chen S, Hamilton R, Simmons CA, Maynes JT, Sun Y. A Micro Device Platform for Continuous Measurement of Contractility, Beating Rate, and Beating Rhythm of hiPSC-Cardiomyocytes inside a Controlled Incubator Environment. Acs Applied Materials & Interfaces. PMID 29874032 DOI: 10.1021/Acsami.8B05407  0.302
2018 Simmons CA, Jo H. Correction to: Editorial: Special Issue on Heart Valve Mechanobiology : New Insights into Mechanical Regulation of Valve Disease and Regeneration. Cardiovascular Engineering and Technology. PMID 29797229 DOI: 10.1007/S13239-018-0365-Y  0.313
2018 Zhong A, Mirzaei Z, Simmons CA. The Roles of Matrix Stiffness and ß-Catenin Signaling in Endothelial-to-Mesenchymal Transition of Aortic Valve Endothelial Cells. Cardiovascular Engineering and Technology. PMID 29761409 DOI: 10.1007/S13239-018-0363-0  0.347
2018 Simmons CA, Jo H. Editorial: Special Issue on Heart Valve Mechanobiology : New Insights into Mechanical Regulation of Valve Disease and Regeneration. Cardiovascular Engineering and Technology. PMID 29761407 DOI: 10.1007/S13239-018-0360-3  0.326
2018 Liu H, MacQueen LA, Usprech JF, Maleki H, Sider KL, Doyle MG, Sun Y, Simmons CA. Microdevice arrays with strain sensors for 3D mechanical stimulation and monitoring of engineered tissues. Biomaterials. 172: 30-40. PMID 29715593 DOI: 10.1016/J.Biomaterials.2018.04.041  0.406
2018 Chung J, Wong E, Forbes T, Butany J, Simmons C, Ouzounian M. Aortic Aneurysms Have Distinct Mechanical Phenotypes Based On Valve Morphology Canadian Journal of Cardiology. 34. DOI: 10.1016/J.Cjca.2018.07.305  0.306
2018 Fitzsimmons RE, Aquilino MS, Quigley J, Chebotarev O, Tarlan F, Simmons CA. Generating vascular channels within hydrogel constructs using an economical open-source 3D bioprinter and thermoreversible gels Bioprinting. 9: 7-18. DOI: 10.1016/J.Bprint.2018.02.001  0.316
2018 Zhang X, Simmons CA, Santerre JP. Influence of Cryopreservation on the Differentiation of Adipose Derived Stromal Cells Towards Vascular Smooth Muscle Cells Atherosclerosis Supplements. 32: 143-144. DOI: 10.1016/J.Atherosclerosissup.2018.04.441  0.373
2018 Zhong A, Simmons CA. Mechanical Strain-induced Reactive Oxygen Species and Their Role in Valve Interstitial Cell Calcification Atherosclerosis Supplements. 32: 107. DOI: 10.1016/J.Atherosclerosissup.2018.04.327  0.326
2018 Lam AY, Mirzaei Z, Wei K, Simmons CA. FHL2-RhoA Signalling Regulates Mechanically Induced Aortic Valve Interstitial Cell Osteogenic Differentiation Atherosclerosis Supplements. 32: 2. DOI: 10.1016/J.Atherosclerosissup.2018.04.006  0.373
2017 Safaee H, Bakooshli MA, Davoudi S, Cheng RY, Martowirogo AJ, Li EW, Simmons CA, Gilbert PM. Tethered Jagged-1 Synergizes with Culture Substrate Stiffness to Modulate Notch-Induced Myogenic Progenitor Differentiation. Cellular and Molecular Bioengineering. 10: 501-513. PMID 31719873 DOI: 10.1007/S12195-017-0506-7  0.376
2017 Blaser MC, Wei K, Adams RL, Zhou YQ, Caruso LL, Mirzaei Z, Lam A, Tam RK, Zhang H, Heximer SP, Henkelman M, Simmons CA. Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice. Circulation Research. PMID 29273600 DOI: 10.1161/Circresaha.117.311194  0.329
2017 Zhang X, Bendeck MP, Simmons CA, Santerre JP. Deriving vascular smooth muscle cells from mesenchymal stromal cells: Evolving differentiation strategies and current understanding of their mechanisms. Biomaterials. 145: 9-22. PMID 28843066 DOI: 10.1016/J.Biomaterials.2017.08.028  0.425
2017 Wen J, Tao H, Lau K, Liu H, Simmons CA, Sun Y, Hopyan S. Cell and Tissue Scale Forces Coregulate Fgfr2-Dependent Tetrads and Rosettes in the Mouse Embryo. Biophysical Journal. 112: 2209-2218. PMID 28538157 DOI: 10.1016/J.Bpj.2017.04.024  0.371
2017 Usprech J, Romero DA, Amon CH, Simmons CA. Combinatorial screening of 3D biomaterial properties that promote myofibrogenesis for mesenchymal stromal cell-based heart valve tissue engineering. Acta Biomaterialia. PMID 28532900 DOI: 10.1016/J.Actbio.2017.05.044  0.401
2017 Zhang X, Battiston KG, Labow RS, Simmons CA, Santerre JP. Generating favourable growth factor and protease release profiles to enable extracellular matrix accumulation within an in vitro tissue engineering environment. Acta Biomaterialia. PMID 28242454 DOI: 10.1016/J.Actbio.2017.02.041  0.363
2017 Wong JF, Young EWK, Simmons CA. Computational analysis of integrated biosensing and shear flow in a microfluidic vascular model Aip Advances. 7: 115116. DOI: 10.1063/1.5006655  0.322
2017 Zhang X, Battiston KG, Simmons CA, Santerre JP. Differential Regulation of Extracellular Matrix Components Using Different Vitamin C Derivatives in Mono- and Coculture Systems Acs Biomaterials Science & Engineering. 4: 3768-3778. DOI: 10.1021/Acsbiomaterials.7B00389  0.413
2016 Ebady R, Niddam AF, Boczula AE, Kim YR, Gupta N, Tang TT, Odisho T, Zhi H, Simmons CA, Skare JT, Moriarty TJ. Biomechanics of Borrelia burgdorferi Vascular Interactions. Cell Reports. PMID 27568563 DOI: 10.1016/J.Celrep.2016.08.013  0.305
2016 Loai S, Haedicke I, Mirzaei Z, Simmons CA, Zhang XA, Cheng HM. Positive-contrast cellular MRI of embryonic stem cells for tissue regeneration using a highly efficient T1 MRI contrast agent. Journal of Magnetic Resonance Imaging : Jmri. PMID 27185221 DOI: 10.1002/Jmri.25299  0.317
2016 Usprech J, Chen WL, Simmons CA. Heart valve regeneration: the need for systems approaches. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. PMID 26862013 DOI: 10.1002/Wsbm.1329  0.411
2015 Liu H, Usprech J, Sun Y, Simmons CA. A microfabricated platform with hydrogel arrays for 3D mechanical stimulation of cells. Acta Biomaterialia. PMID 26646540 DOI: 10.1016/J.Actbio.2015.11.054  0.379
2015 Nejad SP, Blaser MC, Paul Santerre J, Caldarone CA, Simmons CA. Biomechanical conditioning of tissue engineered heart valves: Too much of a good thing? Advanced Drug Delivery Reviews. PMID 26555371 DOI: 10.1016/J.Addr.2015.11.003  0.397
2015 Ireland RG, Simmons CA. Human Pluripotent Stem Cell Mechanobiology: Manipulating the Biophysical Microenvironment for Regenerative Medicine and Tissue Engineering Applications. Stem Cells (Dayton, Ohio). PMID 26189759 DOI: 10.1002/Stem.2105  0.387
2015 Battiston KG, Labow RS, Simmons CA, Santerre JP. Immunomodulatory polymeric scaffold enhances extracellular matrix production in cell co-cultures under dynamic mechanical stimulation. Acta Biomaterialia. PMID 26093069 DOI: 10.1016/J.Actbio.2015.05.038  0.408
2015 Plaza GR, Uyeda TQ, Mirzaei Z, Simmons CA. Study of the influence of actin-binding proteins using linear analyses of cell deformability. Soft Matter. 11: 5435-46. PMID 26059185 DOI: 10.1039/C5Sm00125K  0.314
2015 Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N, Lazic S, Burrows JT, Wong MD, Li D, Deimling S, Ciruna B, Scott I, Simmons C, Henkelman RM, et al. Anisotropic stress orients remodelling of mammalian limb bud ectoderm. Nature Cell Biology. 17: 569-79. PMID 25893915 DOI: 10.1038/Ncb3156  0.318
2015 Kheradvar A, Groves EM, Dasi LP, Alavi SH, Tranquillo R, Grande-Allen KJ, Simmons CA, Griffith B, Falahatpisheh A, Goergen CJ, Mofrad MR, Baaijens F, Little SH, Canic S. Emerging trends in heart valve engineering: Part I. Solutions for future. Annals of Biomedical Engineering. 43: 833-43. PMID 25488074 DOI: 10.1007/S10439-014-1209-Z  0.349
2015 Kheradvar A, Groves EM, Goergen CJ, Alavi SH, Tranquillo R, Simmons CA, Dasi LP, Grande-Allen KJ, Mofrad MR, Falahatpisheh A, Griffith B, Baaijens F, Little SH, Canic S. Emerging trends in heart valve engineering: Part II. Novel and standard technologies for aortic valve replacement. Annals of Biomedical Engineering. 43: 844-57. PMID 25449148 DOI: 10.1007/S10439-014-1191-5  0.304
2015 Mohammadi H, Arora PD, Simmons CA, Janmey PA, McCulloch CA. Inelastic behaviour of collagen networks in cell-matrix interactions and mechanosensation. Journal of the Royal Society, Interface / the Royal Society. 12: 20141074. PMID 25392399 DOI: 10.1098/Rsif.2014.1074  0.355
2015 Kheradvar A, Groves EM, Simmons CA, Griffith B, Alavi SH, Tranquillo R, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MR, Baaijens F, Canic S, Little SH. Emerging trends in heart valve engineering: Part III. Novel technologies for mitral valve repair and replacement. Annals of Biomedical Engineering. 43: 858-70. PMID 25287646 DOI: 10.1007/S10439-014-1129-Y  0.319
2014 Liu H, Wen J, Xiao Y, Liu J, Hopyan S, Radisic M, Simmons CA, Sun Y. In situ mechanical characterization of the cell nucleus by atomic force microscopy. Acs Nano. 8: 3821-8. PMID 24673613 DOI: 10.1021/Nn500553Z  0.333
2014 Battiston KG, Ouyang B, Labow RS, Simmons CA, Santerre JP. Monocyte/macrophage cytokine activity regulates vascular smooth muscle cell function within a degradable polyurethane scaffold. Acta Biomaterialia. 10: 1146-55. PMID 24361424 DOI: 10.1016/J.Actbio.2013.12.022  0.347
2014 Xiao Y, Zhang B, Liu H, Miklas JW, Gagliardi M, Pahnke A, Thavandiran N, Sun Y, Simmons C, Keller G, Radisic M. Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle. Lab On a Chip. 14: 869-82. PMID 24352498 DOI: 10.1039/C3Lc51123E  0.331
2014 Liu H, Tan Q, Geddie WR, Jewett MA, Phillips N, Ke D, Simmons CA, Sun Y. Biophysical characterization of bladder cancer cells with different metastatic potential. Cell Biochemistry and Biophysics. 68: 241-6. PMID 23793959 DOI: 10.1007/S12013-013-9702-9  0.33
2013 Thavandiran N, Dubois N, Mikryukov A, Massé S, Beca B, Simmons CA, Deshpande VS, McGarry JP, Chen CS, Nanthakumar K, Keller GM, Radisic M, Zandstra PW. Design and formulation of functional pluripotent stem cell-derived cardiac microtissues. Proceedings of the National Academy of Sciences of the United States of America. 110: E4698-707. PMID 24255110 DOI: 10.1073/Pnas.1311120110  0.371
2013 Heckler AF, Mirzaei Z, Pereira I, Simmons CA, Gong SG. Development of a three-dimensional in vitro model system to study orthodontic tooth movement Archives of Oral Biology. 58: 1498-1510. PMID 23845751 DOI: 10.1016/J.Archoralbio.2013.06.011  0.327
2013 Gould ST, Srigunapalan S, Simmons CA, Anseth KS. Hemodynamic and cellular response feedback in calcific aortic valve disease. Circulation Research. 113: 186-97. PMID 23833293 DOI: 10.1161/Circresaha.112.300154  0.381
2013 Liu H, Sun Y, Simmons CA. Determination of local and global elastic moduli of valve interstitial cells cultured on soft substrates. Journal of Biomechanics. 46: 1967-71. PMID 23746597 DOI: 10.1016/J.Jbiomech.2013.05.001  0.401
2013 MacQueen L, Sun Y, Simmons CA. Mesenchymal stem cell mechanobiology and emerging experimental platforms. Journal of the Royal Society, Interface / the Royal Society. 10: 20130179. PMID 23635493 DOI: 10.1098/Rsif.2013.0179  0.392
2013 Chen MB, Srigunapalan S, Wheeler AR, Simmons CA. A 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell-cell interactions. Lab On a Chip. 13: 2591-8. PMID 23525275 DOI: 10.1039/C3Lc00051F  0.438
2013 Moraes C, Likhitpanichkul M, Lam CJ, Beca BM, Sun Y, Simmons CA. Microdevice array-based identification of distinct mechanobiological response profiles in layer-specific valve interstitial cells. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 673-80. PMID 23403640 DOI: 10.1039/C3Ib20254B  0.427
2012 Al-Haque S, Miklas JW, Feric N, Chiu LL, Chen WL, Simmons CA, Radisic M. Hydrogel substrate stiffness and topography interact to induce contact guidance in cardiac fibroblasts. Macromolecular Bioscience. 12: 1342-53. PMID 22927323 DOI: 10.1002/Mabi.201200042  0.33
2012 Wyss K, Yip CY, Mirzaei Z, Jin X, Chen JH, Simmons CA. The elastic properties of valve interstitial cells undergoing pathological differentiation. Journal of Biomechanics. 45: 882-7. PMID 22189247 DOI: 10.1016/J.Jbiomech.2011.11.030  0.441
2012 Srigunapalan S, Eydelnant IA, Simmons CA, Wheeler AR. A digital microfluidic platform for primary cell culture and analysis. Lab On a Chip. 12: 369-75. PMID 22094822 DOI: 10.1039/C1Lc20844F  0.355
2012 Zhao R, Simmons CA. An improved texture correlation algorithm to measure substrate-cytoskeletal network strain transfer under large compressive strain. Journal of Biomechanics. 45: 76-82. PMID 22030122 DOI: 10.1016/J.Jbiomech.2011.10.003  0.316
2012 Liu J, Moraes C, Lu Z, Simmons C, Sun Y. Single Cell Deposition Methods in Cell Biology. 112: 403-420. DOI: 10.1016/B978-0-12-405914-6.00023-8  0.342
2011 Moraes C, Sun Y, Simmons CA. (Micro)managing the mechanical microenvironment. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 959-71. PMID 21931883 DOI: 10.1039/C1Ib00056J  0.375
2011 Chen JH, Simmons CA. Cell-matrix interactions in the pathobiology of calcific aortic valve disease: critical roles for matricellular, matricrine, and matrix mechanics cues. Circulation Research. 108: 1510-24. PMID 21659654 DOI: 10.1161/Circresaha.110.234237  0.41
2011 Yip CY, Blaser MC, Mirzaei Z, Zhong X, Simmons CA. Inhibition of pathological differentiation of valvular interstitial cells by C-type natriuretic peptide. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 1881-9. PMID 21617139 DOI: 10.1161/Atvbaha.111.223974  0.355
2011 Srigunapalan S, Lam C, Wheeler AR, Simmons CA. A microfluidic membrane device to mimic critical components of the vascular microenvironment. Biomicrofluidics. 5: 13409. PMID 21522499 DOI: 10.1063/1.3530598  0.382
2011 Sharifpoor S, Simmons CA, Labow RS, Paul Santerre J. Functional characterization of human coronary artery smooth muscle cells under cyclic mechanical strain in a degradable polyurethane scaffold. Biomaterials. 32: 4816-29. PMID 21463894 DOI: 10.1016/J.Biomaterials.2011.03.034  0.743
2011 Yip CY, Simmons CA. The aortic valve microenvironment and its role in calcific aortic valve disease. Cardiovascular Pathology : the Official Journal of the Society For Cardiovascular Pathology. 20: 177-82. PMID 21256052 DOI: 10.1016/J.Carpath.2010.12.001  0.338
2011 Chen WL, Simmons CA. Lessons from (patho)physiological tissue stiffness and their implications for drug screening, drug delivery and regenerative medicine. Advanced Drug Delivery Reviews. 63: 269-76. PMID 21241759 DOI: 10.1016/J.Addr.2011.01.004  0.391
2011 Chen JH, Chen WL, Sider KL, Yip CY, Simmons CA. β-catenin mediates mechanically regulated, transforming growth factor-β1-induced myofibroblast differentiation of aortic valve interstitial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 590-7. PMID 21127288 DOI: 10.1161/Atvbaha.110.220061  0.325
2011 Lu Z, Moraes C, Ye G, Simmons CA, Sun Y. Correction: Single Cell Deposition and Patterning with a Robotic System Plos One. 6. DOI: 10.1371/Annotation/A67C3A69-Ce0C-49Bf-A592-761C3E741C73  0.346
2011 Moraes C, Zhao R, Likhitpanichkul M, Simmons CA, Sun Y. Semi-confined compression of microfabricated polymerized biomaterial constructs Journal of Micromechanics and Microengineering. 21. DOI: 10.1088/0960-1317/21/5/054014  0.36
2010 Moraes C, Sun Y, Simmons CA. Microfabricated platforms for mechanically dynamic cell culture. Journal of Visualized Experiments : Jove. PMID 21206477 DOI: 10.3791/2224  0.385
2010 Lu Z, Moraes C, Ye G, Simmons CA, Sun Y. Single cell deposition and patterning with a robotic system. Plos One. 5: e13542. PMID 21042403 DOI: 10.1371/Journal.Pone.0013542  0.333
2010 Sharifpoor S, Simmons CA, Labow RS, Santerre JP. A study of vascular smooth muscle cell function under cyclic mechanical loading in a polyurethane scaffold with optimized porosity. Acta Biomaterialia. 6: 4218-28. PMID 20601230 DOI: 10.1016/J.Actbio.2010.06.018  0.741
2010 Yuen A, Laschinger C, Talior I, Lee W, Chan M, Birek J, Young EW, Sivagurunathan K, Won E, Simmons CA, McCulloch CA. Methylglyoxal-modified collagen promotes myofibroblast differentiation. Matrix Biology : Journal of the International Society For Matrix Biology. 29: 537-48. PMID 20423729 DOI: 10.1016/J.Matbio.2010.04.004  0.367
2010 Moraes C, Chen JH, Sun Y, Simmons CA. Microfabricated arrays for high-throughput screening of cellular response to cyclic substrate deformation. Lab On a Chip. 10: 227-34. PMID 20066251 DOI: 10.1039/B914460A  0.375
2010 Young EW, Simmons CA. Macro- and microscale fluid flow systems for endothelial cell biology. Lab On a Chip. 10: 143-60. PMID 20066241 DOI: 10.1039/B913390A  0.345
2010 Young EW, Watson MW, Srigunapalan S, Wheeler AR, Simmons CA. Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection. Analytical Chemistry. 82: 808-16. PMID 20050596 DOI: 10.1021/Ac901560W  0.301
2010 Chen WL, Likhitpanichkul M, Ho A, Simmons CA. Integration of statistical modeling and high-content microscopy to systematically investigate cell-substrate interactions. Biomaterials. 31: 2489-97. PMID 20034663 DOI: 10.1016/J.Biomaterials.2009.12.002  0.385
2010 Bhana B, Iyer RK, Chen WL, Zhao R, Sider KL, Likhitpanichkul M, Simmons CA, Radisic M. Influence of substrate stiffness on the phenotype of heart cells. Biotechnology and Bioengineering. 105: 1148-60. PMID 20014437 DOI: 10.1002/Bit.22647  0.377
2010 Moraes C, Wang G, Sun Y, Simmons CA. A microfabricated platform for high-throughput unconfined compression of micropatterned biomaterial arrays. Biomaterials. 31: 577-84. PMID 19819010 DOI: 10.1016/J.Biomaterials.2009.09.068  0.393
2010 Chen JH, Liu C, You L, Simmons CA. Boning up on Wolff's Law: mechanical regulation of the cells that make and maintain bone. Journal of Biomechanics. 43: 108-18. PMID 19818443 DOI: 10.1016/J.Jbiomech.2009.09.016  0.315
2010 Rask F, Mihic A, Reis L, Dallabrida SM, Ismail NS, Sider K, Simmons CA, Rupnick MA, Weisel RD, Li RK, Radisic M. Hydrogels modified with QHREDGS peptide support cardiomyocyte survival in vitro and after sub-cutaneous implantation Soft Matter. 6: 5089-5099. DOI: 10.1039/C0Sm00362J  0.355
2010 Moraes C, Wyss K, Brisson E, Keith BA, Sun Y, Simmons CA. An undergraduate lab (on-a-chip): Probing single cell mechanics on a microfluidic platform Cellular and Molecular Bioengineering. 3: 319-330. DOI: 10.1007/S12195-010-0124-0  0.323
2009 Zhao R, Wyss K, Simmons CA. Comparison of analytical and inverse finite element approaches to estimate cell viscoelastic properties by micropipette aspiration. Journal of Biomechanics. 42: 2768-73. PMID 19765713 DOI: 10.1016/J.Jbiomech.2009.07.035  0.332
2009 Moraes C, Kagoma YK, Beca BM, Tonelli-Zasarsky RL, Sun Y, Simmons CA. Integrating polyurethane culture substrates into poly(dimethylsiloxane) microdevices. Biomaterials. 30: 5241-50. PMID 19545891 DOI: 10.1016/J.Biomaterials.2009.05.066  0.367
2009 Simmons CA. Aortic valve mechanics: an emerging role for the endothelium. Journal of the American College of Cardiology. 53: 1456-8. PMID 19371830 DOI: 10.1016/J.Jacc.2008.12.052  0.316
2009 Yip CY, Chen JH, Zhao R, Simmons CA. Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 936-42. PMID 19304575 DOI: 10.1161/Atvbaha.108.182394  0.42
2009 Chen JH, Yip CY, Sone ED, Simmons CA. Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. The American Journal of Pathology. 174: 1109-19. PMID 19218344 DOI: 10.2353/Ajpath.2009.080750  0.372
2008 Spiteri CG, Young EW, Simmons CA, Kandel RA, Pilliar RM. Substrate architecture and fluid-induced shear stress during chondrocyte seeding: role of alpha5beta1 integrin. Biomaterials. 29: 2477-89. PMID 18314188 DOI: 10.1016/J.Biomaterials.2008.01.018  0.381
2008 Pho M, Lee W, Watt DR, Laschinger C, Simmons CA, McCulloch CA. Cofilin is a marker of myofibroblast differentiation in cells from porcine aortic cardiac valves American Journal of Physiology - Heart and Circulatory Physiology. 294. PMID 18263709 DOI: 10.1152/Ajpheart.01305.2007  0.422
2007 Young EW, Wheeler AR, Simmons CA. Matrix-dependent adhesion of vascular and valvular endothelial cells in microfluidic channels. Lab On a Chip. 7: 1759-66. PMID 18030398 DOI: 10.1039/B712486D  0.41
2007 Chong SA, Lee W, Arora PD, Laschinger C, Young EW, Simmons CA, Manolson M, Sodek J, McCulloch CA. Methylglyoxal inhibits the binding step of collagen phagocytosis. The Journal of Biological Chemistry. 282: 8510-20. PMID 17229729 DOI: 10.1074/Jbc.M609859200  0.31
2006 Young EW, Wheeler A, Simmons CA. A127. Design of an in vitro microfluidic cell culture system to study aortic valve endothelial cells under shear stress Journal of Molecular and Cellular Cardiology. 40: 901. DOI: 10.1016/J.Yjmcc.2006.03.389  0.372
2006 Ho AS, Yip CY, Simmons CA. A50. Spatial transcriptional profiling of aortic valve interstitial cells Journal of Molecular and Cellular Cardiology. 40: 901. DOI: 10.1016/J.Yjmcc.2006.03.388  0.309
2005 Simmons CA, Grant GR, Manduchi E, Davies PF. Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves. Circulation Research. 96: 792-9. PMID 15761200 DOI: 10.1161/01.Res.0000161998.92009.64  0.339
2005 Murphy WL, Hsiong S, Richardson TP, Simmons CA, Mooney DJ. Effects of a bone-like mineral film on phenotype of adult human mesenchymal stem cells in vitro. Biomaterials. 26: 303-10. PMID 15262472 DOI: 10.1016/J.Biomaterials.2004.02.034  0.35
2004 Simmons CA, Zilberberg J, Davies PF. A rapid, reliable method to isolate high quality endothelial RNA from small spatially-defined locations. Annals of Biomedical Engineering. 32: 1453-9. PMID 15535062 DOI: 10.1114/B:Abme.0000042360.57960.2B  0.343
2004 Simmons CA, Nikolovski J, Thornton AJ, Matlis S, Mooney DJ. Mechanical stimulation and mitogen-activated protein kinase signaling independently regulate osteogenic differentiation and mineralization by calcifying vascular cells. Journal of Biomechanics. 37: 1531-41. PMID 15336928 DOI: 10.1016/J.Jbiomech.2004.01.006  0.385
2004 Davies PF, Passerini AG, Simmons CA. Aortic valve: turning over a new leaf(let) in endothelial phenotypic heterogeneity. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 1331-3. PMID 15297285 DOI: 10.1161/01.Atv.0000130659.89433.C1  0.391
2004 Murphy WL, Simmons CA, Kaigler D, Mooney DJ. Bone regeneration via a mineral substrate and induced angiogenesis. Journal of Dental Research. 83: 204-10. PMID 14981120 DOI: 10.1177/154405910408300304  0.336
2004 Simmons CA, Zilberberg J, Francesco NM, Shi C, Riley R, Davies PF. TRANSCRIPTIONAL PROFILES OF ENDOTHELIUM FROM OPPOSITE SIDES OF THE AORTIC VALVE SUGGEST A LINK BETWEEN HEMODYNAMICS AND VALVULAR CALCIFICATION Cardiovascular Pathology. 13: 186. DOI: 10.1016/J.Carpath.2004.03.561  0.305
2003 Simmons CA, Matlis S, Thornton AJ, Chen S, Wang CY, Mooney DJ. Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. Journal of Biomechanics. 36: 1087-96. PMID 12831733 DOI: 10.1016/S0021-9290(03)00110-6  0.359
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