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Giovanni Offeddu - Publications

Affiliations: 
Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
Tisse engineering, Microfluidics, Biomechanics, Biomaterials
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25 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2025 Floryan M, Cambria E, Blazeski A, Coughlin MF, Wan Z, Offeddu G, Vinayak V, Kant A, Shenoy V, Kamm RD. Remodeling of self-assembled microvascular networks under long term flow. Biorxiv : the Preprint Server For Biology. PMID 40166169 DOI: 10.1101/2025.03.17.643791  0.704
2024 Nguyen HT, Kan EL, Humayun M, Gurvich N, Offeddu GS, Wan Z, Coughlin MF, Renteria DC, Loew A, Wilson S, Zhang C, Vu V, Lee SWL, Tan SL, Barbie D, et al. Patient-specific vascularized tumor model: Blocking monocyte recruitment with multispecific antibodies targeting CCR2 and CSF-1R. Biomaterials. 312: 122731. PMID 39153324 DOI: 10.1016/j.biomaterials.2024.122731  0.779
2024 Offeddu GS, Cambria E, Shelton SE, Haase K, Wan Z, Possenti L, Nguyen HT, Gillrie MR, Hickman D, Knutson CG, Kamm RD. Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2402757. PMID 39041892 DOI: 10.1002/advs.202402757  0.773
2024 Cambria E, Coughlin MF, Floryan MA, Offeddu GS, Shelton SE, Kamm RD. Linking cell mechanical memory and cancer metastasis. Nature Reviews. Cancer. PMID 38238471 DOI: 10.1038/s41568-023-00656-5  0.439
2023 Nguyen HT, Gurvich N, Gillrie MR, Offeddu G, Humayun M, Kan EL, Wan Z, Coughlin MF, Zhang C, Vu V, Ling Lee SW, Tan SL, Barbie D, Hsu J, Kamm RD. Patient-Specific Vascularized Tumor Model: Blocking TAM Recruitment with Multispecific Antibodies Targeting CCR2 and CSF-1R. Biorxiv : the Preprint Server For Biology. PMID 38076998 DOI: 10.1101/2023.11.28.568627  0.778
2023 Chen SW, Blazeski A, Zhang S, Shelton SE, Offeddu GS, Kamm RD. Development of a perfusable, hierarchical microvasculature-on-a-chip model. Lab On a Chip. 23: 4552-4564. PMID 37771308 DOI: 10.1039/d3lc00512g  0.557
2023 Rota A, Possenti L, Offeddu GS, Senesi M, Stucchi A, Venturelli I, Rancati T, Zunino P, Kamm RD, Costantino ML. A three-dimensional method for morphological analysis and flow velocity estimation in microvasculature on-a-chip. Bioengineering & Translational Medicine. 8: e10557. PMID 37693050 DOI: 10.1002/btm2.10557  0.492
2022 Offeddu GS, Serrano JC, Wan Z, Bryniarski MA, Humphreys SC, Chen SW, Dhoolypala H, Conner K, Kamm RD. Microphysiological endothelial models to characterize subcutaneous drug absorption. Altex. PMID 36533850 DOI: 10.14573/altex.2207131  0.723
2022 Ibrahim LI, Hajal C, Offeddu GS, Gillrie MR, Kamm RD. Omentum-on-a-chip: A multicellular, vascularized microfluidic model of the human peritoneum for the study of ovarian cancer metastases. Biomaterials. 288: 121728. PMID 35995621 DOI: 10.1016/j.biomaterials.2022.121728  0.798
2022 Straehla JP, Hajal C, Safford HC, Offeddu GS, Boehnke N, Dacoba TG, Wyckoff J, Kamm RD, Hammond PT. A predictive microfluidic model of human glioblastoma to assess trafficking of blood-brain barrier-penetrant nanoparticles. Proceedings of the National Academy of Sciences of the United States of America. 119: e2118697119. PMID 35648828 DOI: 10.1073/pnas.2118697119  0.786
2022 Hajal C, Offeddu GS, Shin Y, Zhang S, Morozova O, Hickman D, Knutson CG, Kamm RD. Engineered human blood-brain barrier microfluidic model for vascular permeability analyses. Nature Protocols. PMID 34997242 DOI: 10.1038/s41596-021-00635-w  0.76
2021 Wan Z, Zhang S, Zhong AX, Shelton SE, Campisi M, Sundararaman SK, Offeddu GS, Ko E, Ibrahim L, Coughlin MF, Liu T, Bai J, Barbie DA, Kamm RD. A robust vasculogenic microfluidic model using human immortalized endothelial cells and Thy1 positive fibroblasts. Biomaterials. 276: 121032. PMID 34303155 DOI: 10.1016/j.biomaterials.2021.121032  0.767
2021 Offeddu GS, Hajal C, Foley CR, Wan Z, Ibrahim L, Coughlin MF, Kamm RD. The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination. Communications Biology. 4: 255. PMID 33637851 DOI: 10.1038/s42003-021-01774-2  0.772
2021 Offeddu GS, Serrano JC, Chen SW, Shelton SE, Shin Y, Floryan M, Kamm RD. Microheart: A microfluidic pump for functional vascular culture in microphysiological systems. Journal of Biomechanics. 119: 110330. PMID 33631662 DOI: 10.1016/j.jbiomech.2021.110330  0.48
2021 Hajal C, Ibrahim L, Serrano JC, Offeddu GS, Kamm RD. The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D in vitro microvascular platform. Biomaterials. 265: 120470. PMID 33190735 DOI: 10.1016/j.biomaterials.2020.120470  0.787
2020 Haase K, Offeddu GS, Gillrie MR, Kamm RD. Endothelial Regulation of Drug Transport in a 3D Vascularized Tumor Model. Advanced Functional Materials. 30. PMID 33692661 DOI: 10.1002/Adfm.202002444  0.571
2020 Offeddu GS, Mohee L, Cameron RE. Scale and structure dependent solute diffusivity within microporous tissue engineering scaffolds. Journal of Materials Science. Materials in Medicine. 31: 46. PMID 32367247 DOI: 10.1007/s10856-020-06381-x  0.521
2019 Offeddu GS, Possenti L, Loessberg-Zahl JT, Zunino P, Roberts J, Han X, Hickman D, Knutson CG, Kamm RD. Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution. Small (Weinheim An Der Bergstrasse, Germany). e1902393. PMID 31497931 DOI: 10.1002/Smll.201902393  0.44
2019 Offeddu GS, Haase K, Gillrie MR, Li R, Morozova O, Hickman D, Knutson CG, Kamm RD. An on-chip model of protein paracellular and transcellular permeability in the microcirculation. Biomaterials. 212: 115-125. PMID 31112823 DOI: 10.1016/J.Biomaterials.2019.05.022  0.494
2018 Offeddu GS, Tanase CE, Toumpaniari S, Oyen ML, Cameron RE. Stiffening by Osmotic Swelling Constraint in Cartilage-Like Cell Culture Scaffolds. Macromolecular Bioscience. 18: e1800247. PMID 30187996 DOI: 10.1002/mabi.201800247  0.697
2017 Offeddu GS, Mela I, Jeggle P, Henderson RM, Smoukov SK, Oyen ML. Cartilage-like electrostatic stiffening of responsive cryogel scaffolds. Scientific Reports. 7: 42948. PMID 28230077 DOI: 10.1038/Srep42948  0.615
2016 Bergholt MS, St-Pierre JP, Offeddu GS, Parmar PA, Albro MB, Puetzer JL, Oyen ML, Stevens MM. Raman Spectroscopy Reveals New Insights into the Zonal Organization of Native and Tissue-Engineered Articular Cartilage. Acs Central Science. 2: 885-895. PMID 28058277 DOI: 10.1021/Acscentsci.6B00222  0.586
2016 Offeddu GS, Ashworth JC, Cameron RE, Oyen ML. Structural determinants of hydration, mechanics and fluid flow in freeze-dried collagen scaffolds. Acta Biomaterialia. 41: 193-203. PMID 27255358 DOI: 10.1016/J.Actbio.2016.05.024  0.73
2015 Offeddu GS, Ashworth JC, Cameron RE, Oyen ML. Multi-scale mechanical response of freeze-dried collagen scaffolds for tissue engineering applications. Journal of the Mechanical Behavior of Biomedical Materials. 42: 19-25. PMID 25460922 DOI: 10.1016/j.jmbbm.2014.10.015  0.697
2014 Butcher AL, Offeddu GS, Oyen ML. Nanofibrous hydrogel composites as mechanically robust tissue engineering scaffolds Trends in Biotechnology. 32: 564-570. PMID 25294495 DOI: 10.1016/j.tibtech.2014.09.001  0.599
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