| Year |
Citation |
Score |
| 2024 |
Das N, Roy J, Patra B, Saunders E, Sarkar D, Goon S, Sinha BP, Roy S, Roy S, Sarif J, Bandopadhyay P, Barik S, Mukherjee S, McNamara N, Varghese S, ... ... Baell J, et al. Hit-to-lead optimization of 2-aminoquinazolines as anti-microbial agents against Leishmania donovani. European Journal of Medicinal Chemistry. 269: 116256. PMID 38461679 DOI: 10.1016/j.ejmech.2024.116256 |
0.353 |
|
| 2024 |
Varghese S, Srivastava A, Wong SW, Le T, Pitcher N, Mesnard M, Lallemand C, Rahmani R, Moawad SR, Huang F, He T, Sleebs BE, Barrett MP, Sykes ML, Avery VM, ... ... Baell JB, et al. Novel aroyl guanidine anti-trypanosomal compounds that exert opposing effects on parasite energy metabolism. European Journal of Medicinal Chemistry. 268: 116162. PMID 38394930 DOI: 10.1016/j.ejmech.2024.116162 |
0.376 |
|
| 2023 |
Dahlin JL, Hua BK, Zucconi BE, Nelson SD, Singh S, Carpenter AE, Shrimp JH, Lima-Fernandes E, Wawer MJ, Chung LPW, Agrawal A, O'Reilly M, Barsyte-Lovejoy D, Szewczyk M, Li F, ... ... Baell JB, et al. Reference compounds for characterizing cellular injury in high-content cellular morphology assays. Nature Communications. 14: 1364. PMID 36914634 DOI: 10.1038/s41467-023-36829-x |
0.394 |
|
| 2023 |
Beveridge J, Tran E, Deora GS, Huang F, Wang Y, Stockton K, Cotillo I, Martinez Martinez MS, Gonzalez S, Castañeda P, Sherman J, Rodriguez A, Kessler A, Baell JB. Novel Diarylthioether Compounds as Agents for the Treatment of Chagas Disease. Journal of Medicinal Chemistry. PMID 36626662 DOI: 10.1021/acs.jmedchem.2c01725 |
0.439 |
|
| 2022 |
Barbaro L, Nagalingam G, Triccas JA, Tan L, West NP, Priebbenow DL, Baell JB. Discovery of Anti-tubercular Analogues of Bedaquiline with Modified A-, B- and C-Ring Subunits. Chemmedchem. e202200533. PMID 36259365 DOI: 10.1002/cmdc.202200533 |
0.691 |
|
| 2022 |
McNamara N, Saunders E, Varghese S, Zheng R, Simpson K, Varma DM, Johnson MM, Hasan Zahid MS, Bachelder EM, Ainslie KM, No JH, Koh D, Shum D, Das N, Patra B, ... ... Baell J, et al. Hit-to-lead optimization of novel phenyl imidazole carboxamides that are active against Leishmania donovani. European Journal of Medicinal Chemistry. 240: 114577. PMID 35810535 DOI: 10.1016/j.ejmech.2022.114577 |
0.432 |
|
| 2021 |
Barbaro L, Nagalingam G, Triccas JA, Tan L, West NP, Baell JB, Priebbenow DL. Synthesis and evaluation of pyridine-derived bedaquiline analogues containing modifications at the A-ring subunit. Rsc Medicinal Chemistry. 12: 943-959. PMID 34223160 DOI: 10.1039/d1md00063b |
0.696 |
|
| 2021 |
Barbaro L, Nagalingam G, Triccas JA, Tan L, West NP, Baell JB, Priebbenow DL. Synthesis and evaluation of pyridine-derived bedaquiline analogues containing modifications at the A-ring subunit. Rsc Medicinal Chemistry. 12: 943-959. PMID 34223160 DOI: 10.1039/d1md00063b |
0.696 |
|
| 2021 |
Priebbenow DL, Mathiew M, Shi DH, Harjani JR, Beveridge JG, Chavchich M, Edstein MD, Duffy S, Avery VM, Jacobs RT, Brand S, Shackleford DM, Wang W, Zhong L, Lee G, ... ... Baell JB, et al. Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines. Journal of Medicinal Chemistry. PMID 33759519 DOI: 10.1021/acs.jmedchem.1c00044 |
0.74 |
|
| 2021 |
Dahlin JL, Auld DS, Rothenaigner I, Haney S, Sexton JZ, Nissink JWM, Walsh J, Lee JA, Strelow JM, Willard FS, Ferrins L, Baell JB, Walters MA, Hua BK, Hadian K, et al. Nuisance compounds in cellular assays. Cell Chemical Biology. PMID 33592188 DOI: 10.1016/j.chembiol.2021.01.021 |
0.731 |
|
| 2020 |
McNamara N, Rahmani R, Sykes ML, Avery VM, Baell J. Hit-to-lead optimization of novel benzimidazole phenylacetamides as broad spectrum trypanosomacides. Rsc Medicinal Chemistry. 11: 685-695. PMID 33479668 DOI: 10.1039/d0md00058b |
0.788 |
|
| 2020 |
Preston S, Garcia-Bustos J, Hall LG, Martin SD, Le TG, Kundu A, Ghoshal A, Nguyen NH, Jiao Y, Ruan B, Xue L, Huang F, Chang BCH, McGee SL, Wells TNC, ... ... Baell JB, et al. 1-Methyl-1-pyrazole-5-carboxamide Derivatives Exhibit Unexpected Acute Mammalian Toxicity. Journal of Medicinal Chemistry. PMID 33352050 DOI: 10.1021/acs.jmedchem.0c01793 |
0.307 |
|
| 2020 |
Varghese S, Rahmani R, Drew DR, Beeson JG, Baum J, Smith BJ, Baell J. Structure activity studies of truncated latrunculin analogues with anti-malarial activity. Chemmedchem. PMID 32929894 DOI: 10.1002/Cmdc.202000399 |
0.77 |
|
| 2020 |
Mathiew M, Dennis B, Bennetts F, Su E, Nguyen N, Botteon A, Baell J, Ventura S. Synthesis of 2-phenyl-5,6,7,8-tetrahydroquinoxaline derivatives and screening for P2X1-purinoreceptor antagonist activity in isolated preparations of rat vas deferens, for translation into a male contraceptive. Biology of Reproduction. PMID 32648904 DOI: 10.1093/biolre/ioaa117 |
0.319 |
|
| 2020 |
Jiao Y, Preston S, Hofmann A, Taki A, Baell J, Chang BCH, Jabbar A, Gasser RB. A perspective on the discovery of selected compounds with anthelmintic activity against the barber's pole worm-Where to from here? Advances in Parasitology. 108: 1-45. PMID 32291083 DOI: 10.1016/Bs.Apar.2019.12.003 |
0.538 |
|
| 2020 |
Varghese S, Rahmani R, Russell S, Deora GS, Ferrins L, Toynton A, Jones A, Sykes M, Kessler A, Eufrásio A, Cordeiro AT, Sherman J, Rodriguez A, Avery VM, Piggott MJ, ... Baell JB, et al. Discovery of Potent -Ethylurea Pyrazole Derivatives as Dual Inhibitors of and . Acs Medicinal Chemistry Letters. 11: 278-285. PMID 32184957 DOI: 10.1021/Acsmedchemlett.9B00218 |
0.792 |
|
| 2020 |
Priebbenow DL, Leaver D, Nguyen N, Cleary B, Lagiakos HR, Sanchez J, Xue L, Huang F, Sun Y, Mujumdar P, Mudududdla R, Varghese S, Teguh SC, Charman SA, White KL, ... ... Baell JB, et al. Discovery of Acylsulfonohydrazide-Derived Lysine Acetyltransferase (KAT6A) Inhibitors as Potent Senescence-Inducing Anti-Cancer Agents. Journal of Medicinal Chemistry. PMID 32118427 DOI: 10.1021/Acs.Jmedchem.9B02071 |
0.755 |
|
| 2020 |
Xie Y, Tummala P, Oakley AJ, Deora GS, Nakano Y, Rooke M, Cuellar M, Strasser J, Dahlin JL, Walters MA, Casarotto MG, Board PG, Baell JB. Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors. Journal of Medicinal Chemistry. PMID 32105470 DOI: 10.1021/Acs.Jmedchem.9B01391 |
0.371 |
|
| 2020 |
Ruan B, Zhang Y, Tadesse S, Preston S, Taki AC, Jabbar A, Hofmann A, Jiao Y, Garcia-Bustos J, Harjani J, Le TG, Varghese S, Teguh S, Xie Y, Odiba J, ... ... Baell J, et al. Synthesis and structure-activity relationship study of pyrrolidine-oxadiazoles as anthelmintics against Haemonchus contortus. European Journal of Medicinal Chemistry. 190: 112100. PMID 32018095 DOI: 10.1016/J.Ejmech.2020.112100 |
0.529 |
|
| 2019 |
Vuckovic Z, Gentry PR, Berizzi AE, Hirata K, Varghese S, Thompson G, van der Westhuizen ET, Burger WAC, Rahmani R, Valant C, Langmead CJ, Lindsley CW, Baell JB, Tobin AB, Sexton PM, et al. Crystal structure of the M muscarinic acetylcholine receptor. Proceedings of the National Academy of Sciences of the United States of America. PMID 31772027 DOI: 10.2210/Pdb6Ol9/Pdb |
0.719 |
|
| 2019 |
Leaver D, Cleary B, Nguyen NT, Priebbenow DL, Lagiakos HR, Sanchez J, Xue L, Huang F, Sun Y, Mujumdar P, Mudududdla R, Varghese S, Teguh S, Charman SA, White K, ... ... Baell JB, et al. Discovery of benzoylsulfonohydrazides as potent inhibitors of the histone acetyltransferase KAT6A. Journal of Medicinal Chemistry. PMID 31256587 DOI: 10.2210/Pdb6Oio/Pdb |
0.706 |
|
| 2019 |
Deora GS, Qin C, Vecchio E, Debono A, Priebbenow D, Brady R, Beveridge J, Teguh S, Deo M, May LT, Krippner GY, Ritchie R, Baell JB. Substituted Pyridazin-3(2H)-ones as Highly Potent and Biased Formyl Peptide Receptors Agonists. Journal of Medicinal Chemistry. PMID 31038950 DOI: 10.1021/Acs.Jmedchem.8B01912 |
0.672 |
|
| 2019 |
Le T, Kundu A, Goshal A, Nguyen N, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang B, Garcia-Bustos J, Wells TNC, Palmer MJ, ... ... Baell JB, et al. Novel 1-Methyl-1 Η-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity. Journal of Medicinal Chemistry. PMID 30875218 DOI: 10.1021/acs.jmedchem.8b01790 |
0.415 |
|
| 2018 |
Jiao Y, Preston S, Garcia-Bustos JF, Baell JB, Ventura S, Le T, McNamara N, Nguyen N, Botteon A, Skinner C, Danne J, Ellis S, Koehler AV, Wang T, Chang BCH, et al. Tetrahydroquinoxalines induce a lethal evisceration phenotype in Haemonchus contortus in vitro. International Journal For Parasitology. Drugs and Drug Resistance. 9: 59-71. PMID 30690282 DOI: 10.1016/J.Ijpddr.2018.12.007 |
0.375 |
|
| 2018 |
Le T, Kundu A, Ghoshal A, Nguyen N, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang B, Garcia-Bustos J, Wells TNC, Palmer MJ, ... ... Baell JB, et al. Structure-activity relationship studies of tolfenpyrad reveal sub-nanomolar inhibitors of Haemonchus contortus development. Journal of Medicinal Chemistry. PMID 30571110 DOI: 10.1021/acs.jmedchem.8b01789 |
0.355 |
|
| 2018 |
Choi JP, Wang R, Yang X, Wang X, Wang L, Ting KK, Foley M, Cogger V, Yang Z, Liu F, Han Z, Liu R, Baell J, Zheng X. Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations. Science Advances. 4: eaau0731. PMID 30417093 DOI: 10.1126/Sciadv.Aau0731 |
0.39 |
|
| 2018 |
Le T, Kundu A, Ghoshal A, Nguyen N, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang B, Garcia-Bustos J, Jabbar A, Wells TNC, ... ... Baell JB, et al. Optimization of Novel 1-Methyl-1H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm. Journal of Medicinal Chemistry. PMID 30403349 DOI: 10.1021/acs.jmedchem.8b01544 |
0.365 |
|
| 2018 |
Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, ... ... Baell J, et al. The Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery. Clinical and Translational Science. PMID 29877628 DOI: 10.1111/Cts.12570 |
0.344 |
|
| 2018 |
Thomas DR, Lundberg L, Pinkham C, Shechter S, Debono A, Baell J, Wagstaff KM, Hick CA, Kehn-Hall K, Jans DA. Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening. Antiviral Research. PMID 29337164 DOI: 10.1016/J.Antiviral.2018.01.007 |
0.408 |
|
| 2017 |
Nguyen N, Wilson DW, Nagalingam G, Triccas JA, Schneider EK, Li J, Velkov T, Baell J. Broad activity of diphenyleneiodonium analogues against Mycobacterium tuberculosis, malaria parasites and bacterial pathogens. European Journal of Medicinal Chemistry. PMID 29269132 DOI: 10.1016/J.Ejmech.2017.10.010 |
0.466 |
|
| 2017 |
Swarbrick J, Dennis M, Lee M, Harjani J, Ahmed M, Debono A, Pitcher N, Wang ZC, Chhabra S, Barlow N, Rahmani R, Cleary B, Dolezal O, Hattarki M, Aurelio L, ... ... Baell J, et al. 8-Mercaptoguanine derivatives as inhibitors of dihydropteroate synthase. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29171692 DOI: 10.1002/Chem.201704730 |
0.744 |
|
| 2017 |
Dahlin JL, Nelson KM, Strasser JM, Barsyte-Lovejoy D, Szewczyk MM, Organ S, Cuellar M, Singh G, Shrimp JH, Nguyen N, Meier JL, Arrowsmith CH, Brown PJ, Baell JB, Walters MA. Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors. Nature Communications. 8: 1527. PMID 29142305 DOI: 10.1038/S41467-017-01657-3 |
0.385 |
|
| 2017 |
Preston S, Jiao Y, Baell JB, Keiser J, Crawford S, Koehler AV, Wang T, Simpson MM, Kaplan RM, Cowley KJ, Simpson KJ, Hofmann A, Jabbar A, Gasser RB. Screening of the 'Open Scaffolds' collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes. International Journal For Parasitology. Drugs and Drug Resistance. 7: 286-294. PMID 28732272 DOI: 10.1016/J.Ijpddr.2017.05.004 |
0.416 |
|
| 2017 |
Preston S, Korhonen PK, Mouchiroud L, Cornaglia M, McGee SL, Young ND, Davis RA, Crawford S, Nowell C, Ansell BRE, Fisher GM, Andrews KT, Chang BCH, Gijs MAM, Sternberg PW, ... ... Baell J, et al. Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28687609 DOI: 10.1096/Fj.201700288R |
0.346 |
|
| 2017 |
Jiao Y, Preston S, Song H, Jabbar A, Liu Y, Baell J, Hofmann A, Hutchinson D, Wang T, Koehler AV, Fisher GM, Andrews KT, Laleu B, Palmer MJ, Burrows JN, et al. Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus. Parasites & Vectors. 10: 272. PMID 28569174 DOI: 10.1186/S13071-017-2191-8 |
0.397 |
|
| 2017 |
Gilson PR, Tan C, Jarman KE, Lowes KN, Curtis JM, Nguyen W, Di Rago AE, Bullen HE, Prinz B, Duffy S, Baell JB, Hutton CA, Jousset Sabroux H, Crabb BS, Avery VM, et al. Optimization of 2-anilino 4-amino substituted quinazolines into potent antimalarial agents with oral in vivo activity. Journal of Medicinal Chemistry. PMID 28080063 DOI: 10.1021/Acs.Jmedchem.6B01673 |
0.402 |
|
| 2016 |
Johnson S, Rahmani R, Drew DR, Williams MJ, Wilkinson M, Tan YH, Huang JX, Tonkin CJ, Beeson JG, Baum J, Smith BJ, Baell JB. Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion. Journal of Medicinal Chemistry. 59: 10994-11005. PMID 28002959 DOI: 10.1021/Acs.Jmedchem.6B01109 |
0.741 |
|
| 2016 |
Williamson AE, Ylioja PM, Robertson MN, Antonova-Koch Y, Avery V, Baell JB, Batchu H, Batra S, Burrows JN, Bhattacharyya S, Calderon F, Charman SA, Clark J, Crespo B, Dean M, et al. Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles. Acs Central Science. 2: 687-701. PMID 27800551 DOI: 10.1021/Acscentsci.6B00086 |
0.354 |
|
| 2016 |
Priebbenow DL, Barbaro L, Baell JB. New synthetic approaches towards analogues of bedaquiline. Organic & Biomolecular Chemistry. 14: 9622-9628. PMID 27714257 DOI: 10.1039/C6Ob01893A |
0.658 |
|
| 2016 |
Russell S, Rahmani R, Jones AJ, Newson H, Neilde K, Cotillo I, Rahmani Khajouei M, Ferrins L, Qureishi S, Nguyen N, Martínez-Martínez MS, Weaver DF, Kaiser M, Riley J, Thomas J, ... ... Baell JB, et al. Hit-to-Lead Optimisation of a Novel Class of Potent, Broad-Spectrum Trypanosomacides. Journal of Medicinal Chemistry. PMID 27548560 DOI: 10.1021/Acs.Jmedchem.6B00442 |
0.809 |
|
| 2016 |
Sutton SK, Carter DR, Kim P, Tan O, Arndt GM, Zhang XD, Baell J, Noll BD, Wang S, Kumar N, McArthur GA, Cheung BB, Marshall GM. A novel compound which sensitizes BRAF wild-type melanoma cells to vemurafenib in a TRIM16-dependent manner. Oncotarget. PMID 27447557 DOI: 10.18632/Oncotarget.10700 |
0.388 |
|
| 2016 |
Preston S, Luo J, Zhang Y, Jabbar A, Crawford S, Baell J, Hofmann A, Hu M, Zhou HB, Gasser RB. Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus. Parasites & Vectors. 9: 346. PMID 27306029 DOI: 10.1186/S13071-016-1612-4 |
0.395 |
|
| 2016 |
Dennis ML, Pitcher NP, Lee MD, Debono AJ, Wang ZC, Harjani JR, Rahmani R, Cleary B, Peat TS, Baell JB, Swarbrick JD. Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli. Journal of Medicinal Chemistry. PMID 27094768 DOI: 10.1021/Acs.Jmedchem.6B00002 |
0.748 |
|
| 2016 |
Stoessel D, Nowell CJ, Jones AJ, Ferrins L, Ellis KM, Riley J, Rahmani R, Read KD, McConville MJ, Avery VM, Baell JB, Creek DJ. Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide Metabolomics. 12. DOI: 10.1007/S11306-016-1062-1 |
0.793 |
|
| 2015 |
Rahmani R, Ban K, Jones AJ, Ferrins L, Ganame D, Sykes ML, Avery VM, White KL, Ryan E, Kaiser M, Charman SA, Baell JB. 6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors. Journal of Medicinal Chemistry. 58: 6753-65. PMID 26247439 DOI: 10.1021/Acs.Jmedchem.5B00438 |
0.813 |
|
| 2015 |
Lagorce D, Sperandio O, Baell JB, Miteva MA, Villoutreix BO. FAF-Drugs3: a web server for compound property calculation and chemical library design. Nucleic Acids Research. 43: W200-7. PMID 25883137 DOI: 10.1093/nar/gkv353 |
0.346 |
|
| 2015 |
Priebbenow DL, Gable RW, Baell J. Regio- and stereoselective iodoacyloxylations of alkynes. The Journal of Organic Chemistry. 80: 4412-8. PMID 25867909 DOI: 10.1021/Acs.Joc.5B00250 |
0.644 |
|
| 2015 |
Preston S, Jabbar A, Nowell C, Joachim A, Ruttkowski B, Baell J, Cardno T, Korhonen PK, Piedrafita D, Ansell BR, Jex AR, Hofmann A, Gasser RB. Low cost whole-organism screening of compounds for anthelmintic activity. International Journal For Parasitology. 45: 333-43. PMID 25746136 DOI: 10.1016/J.Ijpara.2015.01.007 |
0.396 |
|
| 2015 |
Devine SM, Mulcair MD, Debono CO, Leung EW, Nissink JW, Lim SS, Chandrashekaran IR, Vazirani M, Mohanty B, Simpson JS, Baell JB, Scammells PJ, Norton RS, Scanlon MJ. Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold. Journal of Medicinal Chemistry. 58: 1205-14. PMID 25559643 DOI: 10.1021/jm501402x |
0.309 |
|
| 2015 |
Manos-Turvey A, Watson EE, Sykes ML, Jones AJ, Baell JB, Kaiser M, Avery VM, Payne RJ. Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents Medchemcomm. 6: 403-406. DOI: 10.1039/C4Md00406J |
0.389 |
|
| 2014 |
Dennis ML, Chhabra S, Wang ZC, Debono A, Dolezal O, Newman J, Pitcher NP, Rahmani R, Cleary B, Barlow N, Hattarki M, Graham B, Peat TS, Baell JB, Swarbrick JD. Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus. Journal of Medicinal Chemistry. 57: 9612-26. PMID 25357262 DOI: 10.1021/jm501417f |
0.763 |
|
| 2014 |
Ferrins L, Gazdik M, Rahmani R, Varghese S, Sykes ML, Jones AJ, Avery VM, White KL, Ryan E, Charman SA, Kaiser M, Bergström CA, Baell JB. Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei. Journal of Medicinal Chemistry. 57: 6393-402. PMID 24978605 DOI: 10.1021/Jm500191U |
0.805 |
|
| 2014 |
Rashad AA, Jones AJ, Avery VM, Baell J, Keller PA. Facile Synthesis and Preliminary Structure-Activity Analysis of New Sulfonamides Against Trypanosoma brucei. Acs Medicinal Chemistry Letters. 5: 496-500. PMID 24900868 DOI: 10.1021/ml400487t |
0.367 |
|
| 2014 |
Brady RM, Vom A, Roy MJ, Toovey N, Smith BJ, Moss RM, Hatzis E, Huang DC, Parisot JP, Yang H, Street IP, Colman PM, Czabotar PE, Baell JB, Lessene G. De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization. Journal of Medicinal Chemistry. 57: 1323-43. PMID 24456288 DOI: 10.1021/Jm401948B |
0.345 |
|
| 2014 |
Dror RO, Green HF, Valant C, Borhani DW, Valcourt JR, Pan AC, Arlow DH, Canals M, Lane JR, Rahmani R, Baell JB, Sexton PM, Christopoulos A, Shaw DE. Structural Basis for Modulation of a GPCR by Allosteric Drugs Biophysical Journal. 106: 100a. DOI: 10.1016/J.Bpj.2013.11.626 |
0.721 |
|
| 2013 |
Ferrins L, Rahmani R, Baell JB. Drug discovery and human African trypanosomiasis: a disease less neglected? Future Medicinal Chemistry. 5: 1801-41. PMID 24144414 DOI: 10.4155/Fmc.13.162 |
0.779 |
|
| 2013 |
Dror RO, Green HF, Valant C, Borhani DW, Valcourt JR, Pan AC, Arlow DH, Canals M, Lane JR, Rahmani R, Baell JB, Sexton PM, Christopoulos A, Shaw DE. Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs. Nature. 503: 295-9. PMID 24121438 DOI: 10.1038/Nature12595 |
0.718 |
|
| 2013 |
Teguh SC, Klonis N, Duffy S, Lucantoni L, Avery VM, Hutton CA, Baell JB, Tilley L. Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity. Journal of Medicinal Chemistry. 56: 6200-15. PMID 23837878 DOI: 10.1021/Jm400656S |
0.342 |
|
| 2013 |
Ferrins L, Rahmani R, Sykes ML, Jones AJ, Avery VM, Teston E, Almohaywi B, Yin J, Smith J, Hyland C, White KL, Ryan E, Campbell M, Charman SA, Kaiser M, ... Baell JB, et al. 3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis. European Journal of Medicinal Chemistry. 66: 450-65. PMID 23831695 DOI: 10.1016/J.Ejmech.2013.05.007 |
0.804 |
|
| 2013 |
Sleebs BE, Kersten WJ, Kulasegaram S, Nikolakopoulos G, Hatzis E, Moss RM, Parisot JP, Yang H, Czabotar PE, Fairlie WD, Lee EF, Adams JM, Chen L, van Delft MF, Lowes KN, ... ... Baell JB, et al. Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. Journal of Medicinal Chemistry. 56: 5514-40. PMID 23767404 DOI: 10.1021/Jm400556W |
0.305 |
|
| 2013 |
Baell JB. Broad coverage of commercially available lead-like screening space with fewer than 350,000 compounds. Journal of Chemical Information and Modeling. 53: 39-55. PMID 23198812 DOI: 10.1021/ci300461a |
0.354 |
|
| 2013 |
Baell JB, Ferrins L, Falk H, Nikolakopoulos G. PAINS: Relevance to tool compound discovery and fragment-based screening Australian Journal of Chemistry. 66: 1483-1494. DOI: 10.1071/Ch13551 |
0.677 |
|
| 2012 |
Sykes ML, Baell JB, Kaiser M, Chatelain E, Moawad SR, Ganame D, Ioset JR, Avery VM. Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign. Plos Neglected Tropical Diseases. 6: e1896. PMID 23209849 DOI: 10.1371/journal.pntd.0001896 |
0.441 |
|
| 2011 |
Falk H, Connor T, Yang H, Loft KJ, Alcindor JL, Nikolakopoulos G, Surjadi RN, Bentley JD, Hattarki MK, Dolezal O, Murphy JM, Monahan BJ, Peat TS, Thomas T, Baell JB, et al. An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets. Journal of Biomolecular Screening. 16: 1196-205. PMID 22086725 DOI: 10.1177/1087057111421631 |
0.345 |
|
| 2011 |
Lagorce D, Maupetit J, Baell J, Sperandio O, Tufféry P, Miteva MA, Galons H, Villoutreix BO. The FAF-Drugs2 server: a multistep engine to prepare electronic chemical compound collections. Bioinformatics (Oxford, England). 27: 2018-20. PMID 21636592 DOI: 10.1093/Bioinformatics/Btr333 |
0.388 |
|
| 2011 |
Sleebs BE, Ganame D, Levit A, Street IP, Gregg A, Falk H, Baell JB. Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors Medchemcomm. 2: 982-986. DOI: 10.1039/C1Md00138H |
0.335 |
|
| 2011 |
Baell JB. Redox-active nuisance screening compounds and their classification Drug Discovery Today. 16: 840-841. DOI: 10.1016/j.drudis.2011.06.011 |
0.311 |
|
| 2010 |
Baell JB. Observations on screening-based research and some concerning trends in the literature. Future Medicinal Chemistry. 2: 1529-46. PMID 21426147 DOI: 10.4155/fmc.10.237 |
0.328 |
|
| 2010 |
Holloway GA, Parisot JP, Novello PM, Watson KG, Armstrong T, Thompson RC, Street IP, Baell JB. Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi. Bioorganic & Medicinal Chemistry Letters. 20: 1816-8. PMID 20185305 DOI: 10.1016/J.Bmcl.2010.02.022 |
0.364 |
|
| 2010 |
Lackovic K, Parisot JP, Sleebs N, Baell JB, Debien L, Watson KG, Curtis JM, Handman E, Street IP, Kedzierski L. Inhibitors of Leishmania GDP-mannose pyrophosphorylase identified by high-throughput screening of small-molecule chemical library. Antimicrobial Agents and Chemotherapy. 54: 1712-9. PMID 20160053 DOI: 10.1128/Aac.01634-09 |
0.468 |
|
| 2010 |
Baell JB, Holloway GA. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. Journal of Medicinal Chemistry. 53: 2719-40. PMID 20131845 DOI: 10.1021/jm901137j |
0.348 |
|
| 2009 |
Holloway GA, Charman WN, Fairlamb AH, Brun R, Kaiser M, Kostewicz E, Novello PM, Parisot JP, Richardson J, Street IP, Watson KG, Baell JB. Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity. Antimicrobial Agents and Chemotherapy. 53: 2824-33. PMID 19364854 DOI: 10.1128/Aac.01568-08 |
0.379 |
|
| 2007 |
Holloway GA, Baell JB, Fairlamb AH, Novello PM, Parisot JP, Richardson J, Watson KG, Street IP. Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening. Bioorganic & Medicinal Chemistry Letters. 17: 1422-7. PMID 17194585 DOI: 10.1016/J.Bmcl.2006.11.090 |
0.366 |
|
| 2004 |
He H, Hirokawa Y, Gazit A, Yamashita Y, Mano H, Kawakami Y, Kawakami, Hsieh CY, Kung HJ, Lessene G, Baell J, Levitzki A, Maruta H. The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation. Cancer Biology & Therapy. 3: 96-101. PMID 14726663 DOI: 10.4161/Cbt.3.1.643 |
0.305 |
|
| 2003 |
Patel O, Satchell J, Baell J, Fernley R, Coloe P, Macreadie I. Inhibition studies of sulfonamide-containing folate analogs in yeast. Microbial Drug Resistance (Larchmont, N.Y.). 9: 139-46. PMID 12820798 DOI: 10.1089/107662903765826723 |
0.305 |
|
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