Yongcheng Ying, Ph.D.

Affiliations: 
2010 Chemistry Duke University, Durham, NC 
Area:
Synthesis of natural products, signaling pathways in biology
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Jiyong Hong grad student 2010 Duke
 (I. Total syntheses and biological studies of largazole and brasilibactin A. II. Stereoselective synthesis of 2,6-cis- and 2,6-trans-piperidines through an organocatalytic aza -Michael reaction.)
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Fang J, Han D, Hong J, et al. (2014) SVα-MSH, a novel α-melanocyte stimulating hormone analog, ameliorates autoimmune encephalomyelitis through inhibiting autoreactive CD4(+) T cells activation. Journal of Neuroimmunology. 269: 9-19
Lee SU, Kwak HB, Pi SH, et al. (2011) In Vitro and In Vivo Osteogenic Activity of Largazole. Acs Medicinal Chemistry Letters. 2: 248-251
Harrington JM, Park H, Ying Y, et al. (2011) Characterization of Fe(III) sequestration by an analog of the cytotoxic siderophore brasilibactin A: implications for the iron transport mechanism in mycobacteria. Metallomics : Integrated Biometal Science. 3: 464-71
Ying Y, Kim H, Hong J. (2011) Stereoselective synthesis of 2,6-cis- and 2,6-trans-piperidines through organocatalytic aza-Michael reactions: a facile synthesis of (+)-myrtine and (-)-epimyrtine. Organic Letters. 13: 796-9
Liu Y, Salvador LA, Byeon S, et al. (2010) Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor. The Journal of Pharmacology and Experimental Therapeutics. 335: 351-61
Ying Y, Liu Y, Byeon SR, et al. (2008) Synthesis and activity of largazole analogues with linker and macrocycle modification. Organic Letters. 10: 4021-4
Ying Y, Taori K, Kim H, et al. (2008) Total synthesis and molecular target of largazole, a histone deacetylase inhibitor. Journal of the American Chemical Society. 130: 8455-9
Ying Y, Hong J. (2008) ChemInform Abstract: Synthesis of Brasilibactin A and Confirmation of Absolute Configuration of β-Hydroxy Acid Fragment. Cheminform. 39
Ying Y, Hong J. (2007) Synthesis of brasilibactin A and confirmation of absolute configuration of β-hydroxy acid fragment Tetrahedron Letters. 48: 8104-8107
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