Douglas Lowell Theobald, Ph.D.

Affiliations: 
2007- Biochemistry Brandeis University, Waltham, MA, United States 
Area:
Telomeres, molecular evolution, structural bioinformatics, superposition, rhodopsin, bacteriorhodopsin, lactate dehydrogenase, malate dehydrogenase
Website:
http://theobald.brandeis.edu/
Google:
"Douglas Theobald"
Cross-listing: Telomere and Telomerase Tree

Parents

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Steve C. Schultz grad student 1994-2001 CU Boulder
 (Crystallographic and thermodynamic studies of ssDNA sequence discrimination with the Oxytricha nova telomere end -binding protein.)
Deborah S. Wuttke post-doc 2001-2006 CU Boulder (Chemistry Tree)
Christopher Miller post-doc 2006-2007 Brandeis (Chemistry Tree)

Children

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Nathaniel Lazar research assistant 2008-2010 Brandeis
Marcus R. Kelly research assistant 2009-2011 Brandeis
Adam M. Drake research assistant 2010-2013 Brandeis
Joseph R. Jacobowitz research assistant 2012-2014 Brandeis (Telomere and Telomerase Tree)
Michelle Yen Fry research assistant 2013-2014 Brandeis
Changhan Xu research assistant 2015-2017 Brandeis
Miriam Hood research assistant 2015-2018 Brandeis
Simon Olsson grad student 2012-2012 Brandeis
Jeffrey I. Boucher grad student 2008-2013 Brandeis
Phillip A. Steindel grad student 2008-2014 Brandeis (Telomere and Telomerase Tree)
Kristine Ann Mackin grad student 2010-2014 Brandeis (Telomere and Telomerase Tree)
Erin Devine grad student 2011-2015 Brandeis
Richard A. Roy grad student 2012-2018 Brandeis
Brian Clifford Beckett grad student 2013-2019 Brandeis
Jacob D. Wirth grad student 2014-2019 Brandeis
Christoffer H. Norn grad student 2016-2019 University of Lund
Michael Sennett grad student 2018-2022 Brandeis
Brandon Y. Black grad student 2019-2023 Brandeis

Collaborators

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Christopher Miller collaborator 2007- Brandeis (Chemistry Tree)
Paul A. Garrity collaborator 2009- Brandeis (Neurotree)
Jeff Gelles collaborator 2010- Brandeis (Chemistry Tree)
Nikolaus Grigorieff collaborator 2011- Brandeis
Thomas Hamelryck collaborator 2011- Copenhagen University (Computational Biology Tree)
Kantilal Vardichand Mardia collaborator 2011- University of Leeds
Dorothee Kern collaborator 2012- Brandeis (Telomere and Telomerase Tree)
Daniel D. Oprian collaborator 2012- Brandeis (Neurotree)
BETA: Related publications

Publications

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Kumar RP, Matos JO, Black BY, et al. (2024) Crystal Structure of Caryolan-1-ol Synthase, a Sesquiterpene Synthase Catalyzing an Initial Anti-Markovnikov Cyclization Reaction. Biorxiv : the Preprint Server For Biology
Frank HM, Walujkar S, Walsh RM, et al. (2024) Structural basis of ligand specificity and channel activation in an insect gustatory receptor. Cell Reports. 43: 114035
Sennett MA, Theobald DL. (2024) Extant Sequence Reconstruction: The Accuracy of Ancestral Sequence Reconstructions Evaluated by Extant Sequence Cross-Validation. Journal of Molecular Evolution. 92: 181-206
Frank HM, Walujkar S, Walsh RM, et al. (2023) Structure of an insect gustatory receptor. Biorxiv : the Preprint Server For Biology
Ordabayev YA, Friedman LJ, Gelles J, et al. (2022) Bayesian machine learning analysis of single-molecule fluorescence colocalization images. Elife. 11
Stiller JB, Otten R, Häussinger D, et al. (2022) Structure determination of high-energy states in a dynamic protein ensemble. Nature. 603: 528-535
Norn C, André I, Theobald DL. (2021) A thermodynamic model of protein structure evolution explains empirical amino acid substitution matrices. Protein Science : a Publication of the Protein Society
Moreta LS, Al-Sibahi AS, Theobald D, et al. (2019) A Probabilistic Programming Approach to Protein Structure Superposition. Proceedings of the ... Ieee Symposium On Computational Intelligence in Bioinformatics and Computational Biology : Cibcb. Ieee Symposium On Computational Intelligence in Bioinformatics and Computational Biology. 2019
Wirth JD, Boucher JI, Jacobowitz JR, et al. (2018) Functional and Structural Resilience of the Active Site Loop in the Evolution of Plasmodium Lactate Dehydrogenase. Biochemistry
Lamarche LB, Kumar RP, Trieu MM, et al. (2017) Purification and Characterization of RhoPDE, a Retinylidene/Phosphodiesterase Fusion Protein and Potential Optogenetics Tool from the Choanoflagellate Salpingoeca rosetta. Biochemistry
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