| Year |
Citation |
Score |
| 2022 |
Atla G, Bonàs-Guarch S, Cuenca-Ardura M, Beucher A, Crouch DJM, Garcia-Hurtado J, Moran I, Irimia M, Prasad RB, Gloyn AL, Marselli L, Suleiman M, Berney T, de Koning EJP, Kerr-Conte J, ... Todd JA, et al. Genetic regulation of RNA splicing in human pancreatic islets. Genome Biology. 23: 196. PMID 36109769 DOI: 10.1186/s13059-022-02757-0 |
0.34 |
|
| 2022 |
Sandholm N, Rubio García A, Pekalski ML, Inshaw JRJ, Cutler AJ, Todd JA. Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants. Scientific Reports. 12: 14137. PMID 35986039 DOI: 10.1038/s41598-022-18296-4 |
0.345 |
|
| 2022 |
Sioofy-Khojine AB, Richardson SJ, Locke JM, Oikarinen S, Nurminen N, Laine AP, Downes K, Lempainen J, Todd JA, Veijola R, Ilonen J, Knip M, Morgan NG, Hyöty H, Peakman M, et al. Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage. Diabetologia. PMID 35867130 DOI: 10.1007/s00125-022-05753-y |
0.356 |
|
| 2021 |
Robertson CC, Inshaw JRJ, Onengut-Gumuscu S, Chen WM, Santa Cruz DF, Yang H, Cutler AJ, Crouch DJM, Farber E, Bridges SL, Edberg JC, Kimberly RP, Buckner JH, Deloukas P, Divers J, ... Todd JA, et al. Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes. Nature Genetics. PMID 34127860 DOI: 10.1038/s41588-021-00880-5 |
0.333 |
|
| 2021 |
Inshaw JRJ, Sidore C, Cucca F, Stefana MI, Crouch DJM, McCarthy MI, Mahajan A, Todd JA. Analysis of overlapping genetic association in type 1 and type 2 diabetes. Diabetologia. PMID 33830302 DOI: 10.1007/s00125-021-05428-0 |
0.353 |
|
| 2020 |
Boughton C, Allen JM, Tauschmann M, Hartnell S, Wilinska ME, Musolino G, Acerini CL, Dunger PD, Campbell F, Ghatak A, Randell T, Besser R, Trevelyan N, Elleri D, Northam E, ... Todd J, et al. Assessing the effect of closed-loop insulin delivery from onset of type 1 diabetes in youth on residual beta-cell function compared to standard insulin therapy (CLOuD study): a randomised parallel study protocol. Bmj Open. 10: e033500. PMID 32169925 DOI: 10.1136/Bmjopen-2019-033500 |
0.343 |
|
| 2019 |
Ferreira RC, Castro Dopico X, Oliveira JJ, Rainbow DB, Yang JH, Trzupek D, Todd SA, McNeill M, Steri M, Orrù V, Fiorillo E, Crouch DJM, Pekalski ML, Cucca F, Tree TI, ... ... Todd JA, et al. Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp Risk Allele Drive the Expansion of FOXP3 Regulatory T Cells and PD-1 Expression. Frontiers in Immunology. 10: 2606. PMID 31781109 DOI: 10.3389/Fimmu.2019.02606 |
0.303 |
|
| 2019 |
Ramos-Rodríguez M, Raurell-Vila H, Colli ML, Alvelos MI, Subirana-Granés M, Juan-Mateu J, Norris R, Turatsinze JV, Nakayasu ES, Webb-Robertson BM, Inshaw JRJ, Marchetti P, Piemonti L, Esteller M, Todd JA, et al. The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes. Nature Genetics. PMID 31676868 DOI: 10.1038/S41588-019-0524-6 |
0.347 |
|
| 2019 |
Inshaw JRJ, Cutler AJ, Crouch DJM, Wicker LS, Todd JA. Genetic Variants Predisposing Most Strongly to Type 1 Diabetes Diagnosed Under Age 7 Years Lie Near Candidate Genes That Function in the Immune System and in Pancreatic β-Cells. Diabetes Care. PMID 31558544 DOI: 10.2337/Dc19-0803 |
0.391 |
|
| 2019 |
Ziegler AG, Achenbach P, Berner R, Casteels K, Danne T, Gündert M, Hasford J, Hoffmann VS, Kordonouri O, Lange K, Elding Larsson H, Lundgren M, Snape MD, Szypowska A, Todd JA, et al. Oral insulin therapy for primary prevention of type 1 diabetes in infants with high genetic risk: the GPPAD-POInT (global platform for the prevention of autoimmune diabetes primary oral insulin trial) study protocol. Bmj Open. 9: e028578. PMID 31256036 DOI: 10.1136/Bmjopen-2018-028578 |
0.383 |
|
| 2019 |
Winkler C, Haupt F, Heigermoser M, Zapardiel-Gonzalo J, Ohli J, Faure T, Kalideri E, Hommel A, Delivani P, Berner R, Kordonouri O, Roloff F, von dem Berge T, Lange K, Oltarzewski M, ... Todd JA, et al. Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials-GPPAD-02 study design and first results. Pediatric Diabetes. PMID 31192505 DOI: 10.1111/Pedi.12870 |
0.362 |
|
| 2018 |
Seelig E, Howlett J, Porter L, Truman L, Heywood J, Kennet J, Arbon EL, Anselmiova K, Walker NM, Atkar R, Pekalski ML, Rytina E, Evans M, Wicker LS, Todd JA, et al. The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes. Jci Insight. 3. PMID 30282826 DOI: 10.1172/Jci.Insight.99306 |
0.356 |
|
| 2018 |
Westra HJ, Martínez-Bonet M, Onengut-Gumuscu S, Lee A, Luo Y, Teslovich N, Worthington J, Martin J, Huizinga T, Klareskog L, Rantapaa-Dahlqvist S, Chen WM, Quinlan A, Todd JA, Eyre S, et al. Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes. Nature Genetics. PMID 30224649 DOI: 10.1038/S41588-018-0216-7 |
0.457 |
|
| 2018 |
Inshaw JRJ, Cutler AJ, Burren OS, Stefana MI, Todd JA. Approaches and advances in the genetic causes of autoimmune disease and their implications. Nature Immunology. PMID 29925982 DOI: 10.1038/S41590-018-0129-8 |
0.356 |
|
| 2018 |
Sun BB, Maranville JC, Peters JE, Stacey D, Staley JR, Blackshaw J, Burgess S, Jiang T, Paige E, Surendran P, Oliver-Williams C, Kamat MA, Prins BP, Wilcox SK, Zimmerman ES, ... Todd JA, et al. Genomic atlas of the human plasma proteome. Nature. 558: 73-79. PMID 29875488 DOI: 10.1038/S41586-018-0175-2 |
0.323 |
|
| 2018 |
Todd JA. Evidence that UBASH3 is a causal gene for type 1 diabetes. European Journal of Human Genetics : Ejhg. PMID 29760431 DOI: 10.1038/S41431-018-0142-2 |
0.435 |
|
| 2017 |
Kindt ASD, Fuerst RW, Knoop J, Laimighofer M, Telieps T, Hippich M, Woerheide MA, Wahl S, Wilson R, Sedlmeier EM, Hommel A, Todd JA, Krumsiek J, Ziegler AG, Bonifacio E. Allele-specific methylation of type 1 diabetes susceptibility genes. Journal of Autoimmunity. PMID 29224923 DOI: 10.1016/J.Jaut.2017.11.008 |
0.467 |
|
| 2017 |
Inshaw JRJ, Walker NM, Wallace C, Bottolo L, Todd JA. The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age. Diabetologia. PMID 28983737 DOI: 10.1007/S00125-017-4440-Y |
0.452 |
|
| 2017 |
Burren OS, Rubio García A, Javierre BM, Rainbow DB, Cairns J, Cooper NJ, Lambourne JJ, Schofield E, Castro Dopico X, Ferreira RC, Coulson R, Burden F, Rowlston SP, Downes K, Wingett SW, ... Todd JA, et al. Chromosome contacts in activated T cells identify autoimmune disease candidate genes. Genome Biology. 18: 165. PMID 28870212 DOI: 10.1186/S13059-017-1285-0 |
0.362 |
|
| 2017 |
Censin JC, Nowak C, Cooper N, Bergsten P, Todd JA, Fall T. Childhood adiposity and risk of type 1 diabetes: A Mendelian randomization study. Plos Medicine. 14: e1002362. PMID 28763444 DOI: 10.1371/Journal.Pmed.1002362 |
0.405 |
|
| 2017 |
Steri M, Orrù V, Idda ML, Pitzalis M, Pala M, Zara I, Sidore C, Faà V, Floris M, Deiana M, Asunis I, Porcu E, Mulas A, Piras MG, Lobina M, ... Todd JA, et al. Overexpression of the Cytokine BAFF and Autoimmunity Risk. The New England Journal of Medicine. 376: 1615-1626. PMID 28445677 DOI: 10.1056/Nejmoa1610528 |
0.393 |
|
| 2017 |
Liston A, Todd JA, Lagou V. Beta-Cell Fragility As a Common Underlying Risk Factor in Type 1 and Type 2 Diabetes. Trends in Molecular Medicine. PMID 28117227 DOI: 10.1016/J.Molmed.2016.12.005 |
0.356 |
|
| 2016 |
Liley J, Todd JA, Wallace C. A method for identifying genetic heterogeneity within phenotypically defined disease subgroups. Nature Genetics. PMID 28024155 DOI: 10.1038/Ng.3751 |
0.403 |
|
| 2016 |
Ziegler AG, Bonifacio E, Powers AC, Todd JA, Harrison LC, Atkinson MA. Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease. Diabetes. 65: 3233-3239. PMID 27959859 DOI: 10.2337/Db16-0687 |
0.416 |
|
| 2016 |
Javierre BM, Burren OS, Wilder SP, Kreuzhuber R, Hill SM, Sewitz S, Cairns J, Wingett SW, Várnai C, Thiecke MJ, Burden F, Farrow S, Cutler AJ, Rehnström K, Downes K, ... Todd JA, et al. Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters. Cell. 167: 1369-1384.e19. PMID 27863249 DOI: 10.1016/J.Cell.2016.09.037 |
0.352 |
|
| 2016 |
Bonifacio E, Mathieu C, Nepom GT, Ziegler AG, Anhalt H, Haller MJ, Harrison LC, Hebrok M, Kushner JA, Norris JM, Peakman M, Powers AC, Todd JA, Atkinson MA. Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity. Diabetologia. PMID 27785529 DOI: 10.1007/S00125-016-4144-8 |
0.37 |
|
| 2016 |
Todd JA, Evangelou M, Cutler AJ, Pekalski ML, Walker NM, Stevens HE, Porter L, Smyth DJ, Rainbow DB, Ferreira RC, Esposito L, Hunter KM, Loudon K, Irons K, Yang JH, et al. Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial. Plos Medicine. 13: e1002139. PMID 27727279 DOI: 10.1371/Journal.Pmed.1002139 |
0.353 |
|
| 2016 |
Arif S, Gibson VB, Nguyen V, Bingley PJ, Todd JA, Guy C, Dunger DB, Dayan CM, Powrie J, Lorenc A, Peakman M. β-cell specific T-lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults. Diabetic Medicine : a Journal of the British Diabetic Association. PMID 27151105 DOI: 10.1111/Dme.13153 |
0.365 |
|
| 2016 |
Todd JA. Intolerable secretion and diabetes in tolerant transgenic mice, revisited. Nature Genetics. 48: 476-7. PMID 27120442 DOI: 10.1038/Ng.3560 |
0.385 |
|
| 2016 |
Ziegler AG, Danne T, Dunger DB, Berner R, Puff R, Kiess W, Agiostratidou G, Todd JA, Bonifacio E. Primary prevention of beta-cell autoimmunity and type 1 diabetes - The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) perspectives. Molecular Metabolism. 5: 255-62. PMID 27069865 DOI: 10.1016/J.Molmet.2016.02.003 |
0.372 |
|
| 2015 |
Truman LA, Pekalski ML, Kareclas P, Evangelou M, Walker NM, Howlett J, Mander AP, Kennet J, Wicker LS, Bond S, Todd JA, Waldron-Lynch F. Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study. Bmj Open. 5: e009799. PMID 26646829 DOI: 10.1136/Bmjopen-2015-009799 |
0.322 |
|
| 2015 |
Fraser HI, Howlett S, Clark J, Rainbow DB, Stanford SM, Wu DJ, Hsieh YW, Maine CJ, Christensen M, Kuchroo V, Sherman LA, Podolin PL, Todd JA, Steward CA, Peterson LB, et al. Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice. Journal of Immunology (Baltimore, Md. : 1950). PMID 26438525 DOI: 10.4049/Jimmunol.1402654 |
0.484 |
|
| 2015 |
Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, Dunger DB, Powrie J, Willcox A, Foulis AK, Richardson SJ, et al. Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63:3835-3845. Diabetes. 64: 3334. PMID 26294431 DOI: 10.2337/Db15-Er09A |
0.367 |
|
| 2015 |
Yang JH, Cutler AJ, Ferreira RC, Reading JL, Cooper NJ, Wallace C, Clarke P, Smyth DJ, Boyce CS, Gao GJ, Todd JA, Wicker LS, Tree TI. Natural variation in IL-2 sensitivity influences regulatory T cell frequency and function in individuals with long-standing type 1 diabetes. Diabetes. PMID 26224887 DOI: 10.2337/Db15-0516 |
0.322 |
|
| 2015 |
Hu X, Deutsch AJ, Lenz TL, Onengut-Gumuscu S, Han B, Chen WM, Howson JM, Todd JA, de Bakker PI, Rich SS, Raychaudhuri S. Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk. Nature Genetics. 47: 898-905. PMID 26168013 DOI: 10.1038/Ng.3353 |
0.365 |
|
| 2015 |
Wallace C, Cutler AJ, Pontikos N, Pekalski ML, Burren OS, Cooper JD, García AR, Ferreira RC, Guo H, Walker NM, Smyth DJ, Rich SS, Onengut-Gumuscu S, Sawcer SJ, Ban M, ... Todd JA, et al. Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping. Plos Genetics. 11: e1005272. PMID 26106896 DOI: 10.1371/Journal.Pgen.1005272 |
0.396 |
|
| 2015 |
Fortune MD, Guo H, Burren O, Schofield E, Walker NM, Ban M, Sawcer SJ, Bowes J, Worthington J, Barton A, Eyre S, Todd JA, Wallace C. Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls. Nature Genetics. 47: 839-46. PMID 26053495 DOI: 10.1038/Ng.3330 |
0.393 |
|
| 2015 |
Heywood J, Evangelou M, Goymer D, Kennet J, Anselmiova K, Guy C, O'Brien C, Nutland S, Brown J, Walker NM, Todd JA, Waldron-Lynch F. Effective recruitment of participants to a phase I study using the internet and publicity releases through charities and patient organisations: analysis of the adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D). Trials. 16: 86. PMID 25881192 DOI: 10.1186/S13063-015-0583-7 |
0.367 |
|
| 2015 |
Onengut-Gumuscu S, Chen WM, Burren O, Cooper NJ, Quinlan AR, Mychaleckyj JC, Farber E, Bonnie JK, Szpak M, Schofield E, Achuthan P, Guo H, Fortune MD, Stevens H, Walker NM, ... Todd JA, et al. Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nature Genetics. 47: 381-6. PMID 25751624 DOI: 10.1038/Ng.3245 |
0.501 |
|
| 2015 |
Guo H, Fortune MD, Burren OS, Schofield E, Todd JA, Wallace C. Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases. Human Molecular Genetics. 24: 3305-13. PMID 25743184 DOI: 10.1093/Hmg/Ddv077 |
0.433 |
|
| 2015 |
Ferreira RC, Simons HZ, Thompson WS, Cutler AJ, Dopico XC, Smyth DJ, Mashar M, Schuilenburg H, Walker NM, Dunger DB, Wallace C, Todd JA, Wicker LS, Pekalski ML. IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients. Diabetologia. 58: 781-90. PMID 25652388 DOI: 10.1007/S00125-015-3509-8 |
0.37 |
|
| 2015 |
Cooper NJ, Shtir CJ, Smyth DJ, Guo H, Swafford AD, Zanda M, Hurles ME, Walker NM, Plagnol V, Cooper JD, Howson JM, Burren OS, Onengut-Gumuscu S, Rich SS, Todd JA. Detection and correction of artefacts in estimation of rare copy number variants and analysis of rare deletions in type 1 diabetes. Human Molecular Genetics. 24: 1774-90. PMID 25424174 DOI: 10.1093/Hmg/Ddu581 |
0.436 |
|
| 2014 |
Mathieu C, Overbergh L, Badenhoop K, Bingley PPJ, Dayan CCM, Demengeot J, Dotta F, Eizirik DL, Lenzen S, Marchetti P, Peakman M, Roep B, Todd J, Rottiers P, Megit S. The Story of NAIMIT - A Framework 7 Project on Type 1 Diabetes. European Endocrinology. 10: 100-105. PMID 29872472 DOI: 10.17925/Ee.2014.10.02.100 |
0.38 |
|
| 2014 |
Evangelou M, Smyth DJ, Fortune MD, Burren OS, Walker NM, Guo H, Onengut-Gumuscu S, Chen WM, Concannon P, Rich SS, Todd JA, Wallace C. A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations. Genetic Epidemiology. 38: 661-70. PMID 25371288 DOI: 10.1002/Gepi.21853 |
0.407 |
|
| 2014 |
Todd JA, Aitman TJ, Cornall RJ, Ghosh S, Hall JR, Hearne CM, Knight AM, Love JM, McAleer MA, Prins JB, Rodrigues N, Lathrop M, Pressey A, DeLarato NH, Peterson LB, et al. Genetic analysis of autoimmune type 1 diabetes mellitus in mice. 1991. Journal of Immunology (Baltimore, Md. : 1950). 193: 7-12. PMID 24951822 |
0.309 |
|
| 2014 |
Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, Dunger DB, Powrie J, Willcox A, Foulis AK, Richardson SJ, et al. Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes. Diabetes. 63: 3835-45. PMID 24939426 DOI: 10.2337/Db14-0365 |
0.421 |
|
| 2014 |
Esposito L, Hunter KM, Clark J, Rainbow DB, Stevens H, Denesha J, Duley S, Dawson S, Coleman G, Nutland S, Bell GL, Moran C, Pekalski M, Todd JA, Wicker LS. Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles. Journal of Immunology (Baltimore, Md. : 1950). 193: 889-900. PMID 24928993 DOI: 10.4049/Jimmunol.1303389 |
0.322 |
|
| 2014 |
Waldron-Lynch F, Kareclas P, Irons K, Walker NM, Mander A, Wicker LS, Todd JA, Bond S. Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial. Bmj Open. 4: e005559. PMID 24898091 DOI: 10.1136/Bmjopen-2014-005559 |
0.303 |
|
| 2014 |
Zanda M, Onengut-Gumuscu S, Walker N, Shtir C, Gallo D, Wallace C, Smyth D, Todd JA, Hurles ME, Plagnol V, Rich SS. A genome-wide assessment of the role of untagged copy number variants in type 1 diabetes. Plos Genetics. 10: e1004367. PMID 24875393 DOI: 10.1371/Journal.Pgen.1004367 |
0.48 |
|
| 2014 |
Thompson WS, Pekalski ML, Simons HZ, Smyth DJ, Castro-Dopico X, Guo H, Guy C, Dunger DB, Arif S, Peakman M, Wallace C, Wicker LS, Todd JA, Ferreira RC. Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes. Clinical and Experimental Immunology. 177: 571-85. PMID 24773525 DOI: 10.1111/Cei.12362 |
0.357 |
|
| 2014 |
Pontikos N, Smyth DJ, Schuilenburg H, Howson JM, Walker NM, Burren OS, Guo H, Onengut-Gumuscu S, Chen WM, Concannon P, Rich SS, Jayaraman J, Jiang W, Traherne JA, Trowsdale J, Todd JA, et al. A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples. Bmc Genomics. 15: 274. PMID 24720548 DOI: 10.1186/1471-2164-15-274 |
0.44 |
|
| 2014 |
Ferreira RC, Guo H, Coulson RM, Smyth DJ, Pekalski ML, Burren OS, Cutler AJ, Doecke JD, Flint S, McKinney EF, Lyons PA, Smith KG, Achenbach P, Beyerlein A, Dunger DB, ... Todd JA, et al. A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes. Diabetes. 63: 2538-50. PMID 24561305 DOI: 10.2337/Db13-1777 |
0.416 |
|
| 2014 |
Todd JA. Constitutive antiviral immunity at the expense of autoimmunity. Immunity. 40: 167-9. PMID 24560191 DOI: 10.1016/J.Immuni.2014.01.009 |
0.305 |
|
| 2014 |
Downes K, Marcovecchio ML, Clarke P, Cooper JD, Ferreira RC, Howson JM, Jolley J, Nutland S, Stevens HE, Walker NM, Wallace C, Dunger DB, Todd JA. Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients. Diabetologia. 57: 366-72. PMID 24264051 DOI: 10.1007/S00125-013-3113-8 |
0.433 |
|
| 2013 |
Hunt KA, Mistry V, Bockett NA, Ahmad T, Ban M, Barker JN, Barrett JC, Blackburn H, Brand O, Burren O, Capon F, Compston A, Gough SC, Jostins L, Kong Y, ... Todd JA, et al. Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature. 498: 232-5. PMID 23698362 DOI: 10.1038/Nature12170 |
0.395 |
|
| 2013 |
Ferreira RC, Freitag DF, Cutler AJ, Howson JM, Rainbow DB, Smyth DJ, Kaptoge S, Clarke P, Boreham C, Coulson RM, Pekalski ML, Chen WM, Onengut-Gumuscu S, Rich SS, Butterworth AS, ... ... Todd JA, et al. Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases. Plos Genetics. 9: e1003444. PMID 23593036 DOI: 10.1371/Journal.Pgen.1003444 |
0.306 |
|
| 2013 |
Di Meglio P, Villanova F, Napolitano L, Tosi I, Terranova Barberio M, Barberio MT, Mak RK, Nutland S, Smith CH, Barker JN, Todd JA, Nestle FO. The IL23R A/Gln381 allele promotes IL-23 unresponsiveness in human memory T-helper 17 cells and impairs Th17 responses in psoriasis patients. The Journal of Investigative Dermatology. 133: 2381-9. PMID 23563201 DOI: 10.1038/Jid.2013.170 |
0.304 |
|
| 2013 |
Erlich HA, Valdes AM, McDevitt SL, Simen BB, Blake LA, McGowan KR, Todd JA, Rich SS, Noble JA. Next generation sequencing reveals the association of DRB3*02:02 with type 1 diabetes. Diabetes. 62: 2618-22. PMID 23462545 DOI: 10.2337/Db12-1387 |
0.403 |
|
| 2013 |
Howson JM, Roy MS, Zeitels L, Stevens H, Todd JA. HLA class II gene associations in African American type 1 diabetes reveal a protective HLA-DRB1*03 haplotype. Diabetic Medicine : a Journal of the British Diabetic Association. 30: 710-6. PMID 23398374 DOI: 10.1111/Dme.12148 |
0.453 |
|
| 2012 |
Maller JB, McVean G, Byrnes J, Vukcevic D, Palin K, Su Z, Howson JM, Auton A, Myers S, Morris A, Pirinen M, Brown MA, Burton PR, Caulfield MJ, ... Todd JA, et al. Bayesian refinement of association signals for 14 loci in 3 common diseases. Nature Genetics. 44: 1294-301. PMID 23104008 DOI: 10.1038/Ng.2435 |
0.417 |
|
| 2012 |
Butter F, Davison L, Viturawong T, Scheibe M, Vermeulen M, Todd JA, Mann M. Proteome-wide analysis of disease-associated SNPs that show allele-specific transcription factor binding. Plos Genetics. 8: e1002982. PMID 23028375 DOI: 10.1371/Journal.Pgen.1002982 |
0.393 |
|
| 2012 |
Zanda M, Onengut S, Walker N, Todd JA, Clayton DG, Rich SS, Hurles ME, Plagnol V. Validity of the family-based association test for copy number variant data in the case of non-linear intensity-genotype relationship. Genetic Epidemiology. 36: 895-8. PMID 22972682 DOI: 10.1002/Gepi.21674 |
0.31 |
|
| 2012 |
Cooper JD, Simmonds MJ, Walker NM, Burren O, Brand OJ, Guo H, Wallace C, Stevens H, Coleman G, Franklyn JA, Todd JA, Gough SC. Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics. 21: 5202-8. PMID 22922229 DOI: 10.1093/Hmg/Dds357 |
0.375 |
|
| 2012 |
Howson JM, Cooper JD, Smyth DJ, Walker NM, Stevens H, She JX, Eisenbarth GS, Rewers M, Todd JA, Akolkar B, Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, et al. Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes. Diabetes. 61: 3012-7. PMID 22891215 DOI: 10.2337/Db11-1694 |
0.496 |
|
| 2012 |
Howson JM, Krause S, Stevens H, Smyth DJ, Wenzlau JM, Bonifacio E, Hutton J, Ziegler AG, Todd JA, Achenbach P. Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases. Diabetologia. 55: 1978-84. PMID 22526605 DOI: 10.1007/S00125-012-2540-2 |
0.448 |
|
| 2012 |
Garg G, Tyler JR, Yang JH, Cutler AJ, Downes K, Pekalski M, Bell GL, Nutland S, Peakman M, Todd JA, Wicker LS, Tree TI. Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function. Journal of Immunology (Baltimore, Md. : 1950). 188: 4644-53. PMID 22461703 DOI: 10.4049/Jimmunol.1100272 |
0.431 |
|
| 2012 |
Wallace C, Rotival M, Cooper JD, Rice CM, Yang JH, McNeill M, Smyth DJ, Niblett D, Cambien F, Tiret L, Todd JA, Clayton DG, Blankenberg S. Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes. Human Molecular Genetics. 21: 2815-24. PMID 22403184 DOI: 10.1093/Hmg/Dds098 |
0.479 |
|
| 2012 |
McHugh SM, Roman S, Davis B, Koch A, Pickett AM, Richardson JC, Miller SR, Wetten S, Cox CJ, Karpe F, Todd JA, Bullmore ET. Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X(7) receptor antagonist: a prospective genotyping approach. British Journal of Clinical Pharmacology. 74: 376-80. PMID 22295949 DOI: 10.1111/J.1365-2125.2012.04200.X |
0.312 |
|
| 2012 |
Cooper JD, Howson JM, Smyth D, Walker NM, Stevens H, Yang JH, She JX, Eisenbarth GS, Rewers M, Todd JA, Akolkar B, Concannon P, Erlich HA, Julier C, Morahan G, et al. Confirmation of novel type 1 diabetes risk loci in families. Diabetologia. 55: 996-1000. PMID 22278338 DOI: 10.1007/S00125-012-2450-3 |
0.458 |
|
| 2012 |
Hunt KA, Smyth DJ, Balschun T, Ban M, Mistry V, Ahmad T, Anand V, Barrett JC, Bhaw-Rosun L, Bockett NA, Brand OJ, Brouwer E, Concannon P, Cooper JD, Dias KR, ... Todd JA, et al. Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nature Genetics. 44: 3-5. PMID 22200769 DOI: 10.1038/Ng.1037 |
0.328 |
|
| 2012 |
Davison LJ, Wallace C, Cooper JD, Cope NF, Wilson NK, Smyth DJ, Howson JM, Saleh N, Al-Jeffery A, Angus KL, Stevens HE, Nutland S, Duley S, Coulson RM, Walker NM, ... Todd JA, et al. Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene. Human Molecular Genetics. 21: 322-33. PMID 21989056 DOI: 10.1093/Hmg/Ddr468 |
0.428 |
|
| 2011 |
Lo B, Swafford AD, Shafer-Weaver KA, Jerome LF, Rakhlin L, Mathern DR, Callahan CA, Jiang P, Davison LJ, Stevens HE, Lucas CL, White J, von Borstel R, Todd JA, Lenardo MJ. Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status. Journal of Translational Medicine. 9: 203. PMID 22123298 DOI: 10.1186/1479-5876-9-203 |
0.388 |
|
| 2011 |
Saleh NM, Raj SM, Smyth DJ, Wallace C, Howson JM, Bell L, Walker NM, Stevens HE, Todd JA. Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes. Diabetes/Metabolism Research and Reviews. 27: 838-43. PMID 22069270 DOI: 10.1002/Dmrr.1259 |
0.433 |
|
| 2011 |
Smyth DJ, Cooper JD, Howson JM, Clarke P, Downes K, Mistry T, Stevens H, Walker NM, Todd JA. FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection. Diabetes. 60: 3081-4. PMID 22025780 DOI: 10.2337/Db11-0638 |
0.435 |
|
| 2011 |
Virgin HW, Todd JA. Metagenomics and personalized medicine. Cell. 147: 44-56. PMID 21962506 DOI: 10.1016/J.Cell.2011.09.009 |
0.375 |
|
| 2011 |
Howson JM, Rosinger S, Smyth DJ, Boehm BO, Todd JA. Genetic analysis of adult-onset autoimmune diabetes. Diabetes. 60: 2645-53. PMID 21873553 DOI: 10.2337/Db11-0364 |
0.415 |
|
| 2011 |
Cotsapas C, Voight BF, Rossin E, Lage K, Neale BM, Wallace C, Abecasis GR, Barrett JC, Behrens T, Cho J, De Jager PL, Elder JT, Graham RR, Gregersen P, Klareskog L, ... Todd JA, et al. Pervasive sharing of genetic effects in autoimmune disease. Plos Genetics. 7: e1002254. PMID 21852963 DOI: 10.1371/Journal.Pgen.1002254 |
0.408 |
|
| 2011 |
Howson JM, Stevens H, Smyth DJ, Walker NM, Chandler KA, Bingley PJ, Todd JA. Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct. Diabetes. 60: 2635-44. PMID 21831970 DOI: 10.2337/Db11-0131 |
0.443 |
|
| 2011 |
Plagnol V, Howson JM, Smyth DJ, Walker N, Hafler JP, Wallace C, Stevens H, Jackson L, Simmonds MJ, Bingley PJ, Gough SC, Todd JA. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. Plos Genetics. 7: e1002216. PMID 21829393 DOI: 10.1371/Journal.Pgen.1002216 |
0.394 |
|
| 2011 |
Todd JA, Knip M, Mathieu C. Strategies for the prevention of autoimmune type 1 diabetes. Diabetic Medicine : a Journal of the British Diabetic Association. 28: 1141-3. PMID 21812815 DOI: 10.1111/J.1464-5491.2011.03400.X |
0.444 |
|
| 2011 |
Mohammed JP, Fusakio ME, Rainbow DB, Moule C, Fraser HI, Clark J, Todd JA, Peterson LB, Savage PB, Wills-Karp M, Ridgway WM, Wicker LS, Mattner J. Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). 187: 337-49. PMID 21613619 DOI: 10.4049/Jimmunol.1003525 |
0.403 |
|
| 2011 |
Rainbow DB, Moule C, Fraser HI, Clark J, Howlett SK, Burren O, Christensen M, Moody V, Steward CA, Mohammed JP, Fusakio ME, Masteller EL, Finger EB, Houchins JP, Naf D, ... Todd JA, et al. Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice. Journal of Immunology (Baltimore, Md. : 1950). 187: 325-36. PMID 21613616 DOI: 10.4049/Jimmunol.1003523 |
0.378 |
|
| 2011 |
Yang JH, Downes K, Howson JM, Nutland S, Stevens HE, Walker NM, Todd JA. Evidence of association with type 1 diabetes in the SLC11A1 gene region. Bmc Medical Genetics. 12: 59. PMID 21524304 DOI: 10.1186/1471-2350-12-59 |
0.502 |
|
| 2011 |
Cooper JD, Smyth DJ, Walker NM, Stevens H, Burren OS, Wallace C, Greissl C, Ramos-Lopez E, Hyppönen E, Dunger DB, Spector TD, Ouwehand WH, Wang TJ, Badenhoop K, Todd JA. Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes. 60: 1624-31. PMID 21441443 DOI: 10.2337/Db10-1656 |
0.394 |
|
| 2011 |
Swafford AD, Howson JM, Davison LJ, Wallace C, Smyth DJ, Schuilenburg H, Maisuria-Armer M, Mistry T, Lenardo MJ, Todd JA. An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes. Diabetes. 60: 1041-4. PMID 21270240 DOI: 10.2337/Db10-0446 |
0.477 |
|
| 2011 |
Morahan G, Mehta M, James I, Chen WM, Akolkar B, Erlich HA, Hilner JE, Julier C, Nerup J, Nierras C, Pociot F, Todd JA, Rich SS. Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs. Diabetes. 60: 1030-40. PMID 21266329 DOI: 10.2337/Db10-1195 |
0.494 |
|
| 2011 |
Burren OS, Adlem EC, Achuthan P, Christensen M, Coulson RM, Todd JA. T1DBase: update 2011, organization and presentation of large-scale data sets for type 1 diabetes research. Nucleic Acids Research. 39: D997-1001. PMID 20937630 DOI: 10.1093/Nar/Gkq912 |
0.377 |
|
| 2010 |
Wan Taib WR, Smyth DJ, Merriman ME, Dalbeth N, Gow PJ, Harrison AA, Highton J, Jones PB, Stamp L, Steer S, Todd JA, Merriman TR. The PTPN22 locus and rheumatoid arthritis: no evidence for an effect on risk independent of Arg620Trp. Plos One. 5: e13544. PMID 20975833 DOI: 10.1371/Journal.Pone.0013544 |
0.339 |
|
| 2010 |
Downes K, Pekalski M, Angus KL, Hardy M, Nutland S, Smyth DJ, Walker NM, Wallace C, Todd JA. Reduced expression of IFIH1 is protective for type 1 diabetes. Plos One. 5. PMID 20844740 DOI: 10.1371/Journal.Pone.0012646 |
0.421 |
|
| 2010 |
Heinig M, Petretto E, Wallace C, Bottolo L, Rotival M, Lu H, Li Y, Sarwar R, Langley SR, Bauerfeind A, Hummel O, Lee YA, Paskas S, Rintisch C, Saar K, ... Todd JA, et al. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature. 467: 460-4. PMID 20827270 DOI: 10.1038/Nature09386 |
0.443 |
|
| 2010 |
Todd JA. D'oh! genes and environment cause Crohn's disease. Cell. 141: 1114-6. PMID 20602995 DOI: 10.1016/J.Cell.2010.06.015 |
0.321 |
|
| 2010 |
Pociot F, Akolkar B, Concannon P, Erlich HA, Julier C, Morahan G, Nierras CR, Todd JA, Rich SS, Nerup J. Genetics of type 1 diabetes: what's next? Diabetes. 59: 1561-71. PMID 20587799 DOI: 10.2337/Db10-0076 |
0.508 |
|
| 2010 |
Todd JA. Etiology of type 1 diabetes. Immunity. 32: 457-67. PMID 20412756 DOI: 10.1016/J.Immuni.2010.04.001 |
0.474 |
|
| 2010 |
Fraser HI, Dendrou CA, Healy B, Rainbow DB, Howlett S, Smink LJ, Gregory S, Steward CA, Todd JA, Peterson LB, Wicker LS. Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene. Journal of Immunology (Baltimore, Md. : 1950). 184: 5075-84. PMID 20363978 DOI: 10.4049/Jimmunol.0903734 |
0.464 |
|
| 2010 |
Craddock N, Hurles ME, Cardin N, Pearson RD, Plagnol V, Robson S, Vukcevic D, Barnes C, Conrad DF, Giannoulatou E, Holmes C, Marchini JL, Stirrups K, Tobin MD, ... Todd JA, et al. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature. 464: 713-20. PMID 20360734 DOI: 10.1038/Nature08979 |
0.474 |
|
| 2010 |
Persengiev S, Koeleman BP, Downes K, Valdigem G, van der Slik AR, Eerligh P, Monsuur A, Bruining GJ, Wijmenga C, Todd JA, Roep BO, Alizadeh BZ. Association analysis of myosin IXB and type 1 diabetes. Human Immunology. 71: 598-601. PMID 20303373 DOI: 10.1016/J.Humimm.2010.03.002 |
0.401 |
|
| 2010 |
Wallace C, Smyth DJ, Maisuria-Armer M, Walker NM, Todd JA, Clayton DG. The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. Nature Genetics. 42: 68-71. PMID 19966805 DOI: 10.1038/Ng.493 |
0.422 |
|
| 2010 |
Steward CA, Humphray S, Plumb B, Jones MC, Quail MA, Rice S, Cox T, Davies R, Bonfield J, Keane TM, Nefedov M, de Jong PJ, Lyons P, Wicker L, Todd J, et al. Genome-wide end-sequenced BAC resources for the NOD/MrkTac() and NOD/ShiLtJ() mouse genomes. Genomics. 95: 105-10. PMID 19909804 DOI: 10.1016/J.Ygeno.2009.10.004 |
0.38 |
|
| 2010 |
Heap GA, Yang JH, Downes K, Healy BC, Hunt KA, Bockett N, Franke L, Dubois PC, Mein CA, Dobson RJ, Albert TJ, Rodesch MJ, Clayton DG, Todd JA, van Heel DA, et al. Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing. Human Molecular Genetics. 19: 122-34. PMID 19825846 DOI: 10.1093/Hmg/Ddp473 |
0.388 |
|
| 2009 |
Dendrou CA, Fung E, Esposito L, Todd JA, Wicker LS, Plagnol V. Fluorescence intensity normalisation: correcting for time effects in large-scale flow cytometric analysis. Advances in Bioinformatics. 476106. PMID 20049162 DOI: 10.1155/2009/476106 |
0.361 |
|
| 2009 |
Cooper JD, Walker NM, Healy BC, Smyth DJ, Downes K, Todd JA. Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1. Genes and Immunity. 10: S95-120. PMID 19956108 DOI: 10.1038/Gene.2009.98 |
0.432 |
|
| 2009 |
Cooper JD, Walker NM, Smyth DJ, Downes K, Healy BC, Todd JA. Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families. Genes and Immunity. 10: S85-94. PMID 19956107 DOI: 10.1038/Gene.2009.97 |
0.461 |
|
| 2009 |
Howson JM, Walker NM, Smyth DJ, Todd JA. Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families. Genes and Immunity. 10: S74-84. PMID 19956106 DOI: 10.1038/Gene.2009.96 |
0.472 |
|
| 2009 |
Kahles H, Morahan G, Todd JA, Badenhoop K. Association analyses of the vitamin D receptor gene in 1654 families with type I diabetes. Genes and Immunity. 10: S60-3. PMID 19956103 DOI: 10.1038/Gene.2009.93 |
0.478 |
|
| 2009 |
Rich SS, Akolkar B, Concannon P, Erlich H, Hilner JE, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Todd JA. Current status and the future for the genetics of type I diabetes. Genes and Immunity. 10: S128-31. PMID 19956094 DOI: 10.1038/Gene.2009.100 |
0.462 |
|
| 2009 |
Rich SS, Akolkar B, Concannon P, Erlich H, Hilner JE, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Todd JA. Overview of the Type I Diabetes Genetics Consortium. Genes and Immunity. 10: S1-4. PMID 19956093 DOI: 10.1038/Gene.2009.84 |
0.467 |
|
| 2009 |
Field SF, Howson JM, Maier LM, Walker S, Walker NM, Smyth DJ, Armour JA, Clayton DG, Todd JA. Experimental aspects of copy number variant assays at CCL3L1. Nature Medicine. 15: 1115-7. PMID 19812562 DOI: 10.1038/Nm1009-1115 |
0.383 |
|
| 2009 |
Todd JA. Stem cells and a cure for type 1 diabetes? Proceedings of the National Academy of Sciences of the United States of America. 106: 15523-4. PMID 19805208 DOI: 10.1073/Pnas.0908373106 |
0.398 |
|
| 2009 |
Dendrou CA, Plagnol V, Fung E, Yang JH, Downes K, Cooper JD, Nutland S, Coleman G, Himsworth M, Hardy M, Burren O, Healy B, Walker NM, Koch K, Ouwehand WH, ... Todd JA, et al. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nature Genetics. 41: 1011-5. PMID 19701192 DOI: 10.1038/Ng.434 |
0.455 |
|
| 2009 |
Raj SM, Howson JM, Walker NM, Cooper JD, Smyth DJ, Field SF, Stevens HE, Todd JA. No association of multiple type 2 diabetes loci with type 1 diabetes. Diabetologia. 52: 2109-16. PMID 19455305 DOI: 10.1007/S00125-009-1391-Y |
0.45 |
|
| 2009 |
Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nature Genetics. 41: 703-7. PMID 19430480 DOI: 10.1038/Ng.381 |
0.421 |
|
| 2009 |
Marcovecchio ML, Dalton RN, Schwarze CP, Prevost AT, Neil HA, Acerini CL, Barrett T, Cooper JD, Edge J, Shield J, Widmer B, Todd JA, Dunger DB. Ambulatory blood pressure measurements are related to albumin excretion and are predictive for risk of microalbuminuria in young people with type 1 diabetes. Diabetologia. 52: 1173-81. PMID 19305965 DOI: 10.1007/S00125-009-1327-6 |
0.371 |
|
| 2009 |
Carr EJ, Clatworthy MR, Lowe CE, Todd JA, Wong A, Vyse TJ, Kamesh L, Watts RA, Lyons PA, Smith KG. Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis. Bmc Medical Genetics. 10: 22. PMID 19265545 DOI: 10.1186/1471-2350-10-22 |
0.342 |
|
| 2009 |
Nejentsev S, Walker N, Riches D, Egholm M, Todd JA. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (New York, N.Y.). 324: 387-9. PMID 19264985 DOI: 10.1126/Science.1167728 |
0.464 |
|
| 2009 |
Rich SS, Akolkar B, Concannon P, Erlich H, Hilner J, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Todd JA. Results of the MHC fine mapping workshop. Diabetes, Obesity and Metabolism. 11: 108-109. PMID 19143823 DOI: 10.1111/J.1463-1326.2008.01011.X |
0.445 |
|
| 2009 |
Howson JM, Walker NM, Clayton D, Todd JA. Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. Diabetes, Obesity & Metabolism. 11: 31-45. PMID 19143813 DOI: 10.1111/J.1463-1326.2008.01001.X |
0.423 |
|
| 2009 |
Concannon P, Chen WM, Julier C, Morahan G, Akolkar B, Erlich HA, Hilner JE, Nerup J, Nierras C, Pociot F, Todd JA, Rich SS. Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. Diabetes. 58: 1018-22. PMID 19136655 DOI: 10.2337/Db08-1551 |
0.47 |
|
| 2009 |
Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg JR, Hauser SL, Compston A, Sawcer S, ... Todd JA, et al. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. Plos Genetics. 5: e1000322. PMID 19119414 DOI: 10.1371/Journal.Pgen.1000322 |
0.419 |
|
| 2009 |
Fung EY, Smyth DJ, Howson JM, Cooper JD, Walker NM, Stevens H, Wicker LS, Todd JA. Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus. Genes and Immunity. 10: 188-91. PMID 19110536 DOI: 10.1038/Gene.2008.99 |
0.474 |
|
| 2009 |
Plagnol V, Smyth DJ, Todd JA, Clayton DG. Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13. Biostatistics (Oxford, England). 10: 327-34. PMID 19039033 DOI: 10.1093/Biostatistics/Kxn039 |
0.464 |
|
| 2009 |
Hafler JP, Maier LM, Cooper JD, Plagnol V, Hinks A, Simmonds MJ, Stevens HE, Walker NM, Healy B, Howson JMM, Maisuria M, Duley S, Coleman G, Gough SCL, Worthington J, ... Todd JA, et al. CD226 Gly307Ser association with multiple autoimmune diseases Genes and Immunity. 10: 5-10. PMID 18971939 DOI: 10.1038/Gene.2008.82 |
0.431 |
|
| 2009 |
Dendrou C, Plagnol V, Fung E, Downes K, Cooper J, Nutland S, Coleman G, Himsworth M, Hardy M, Burren O, Healy B, Walker N, Koch K, Ouwehand W, Bradley J, ... Todd J, et al. F.5. Cell-specific CD25 Expression is Determined by Type 1 Diabetes Associated IL2RA Haplotypes Clinical Immunology. 131. DOI: 10.1016/J.Clim.2009.03.274 |
0.389 |
|
| 2009 |
Plagnol V, Hafler J, Walker N, Schuilenburg H, Howson J, Stevens H, Wicker L, Todd J. F.4. Multiple Genetic Variants Associated with Autoantibody Status in Type 1 Diabetes Patients Clinical Immunology. 131. DOI: 10.1016/J.Clim.2009.03.273 |
0.414 |
|
| 2008 |
Ridgway WM, Peterson LB, Todd JA, Rainbow DB, Healy B, Burren OS, Wicker LS. Gene-gene interactions in the NOD mouse model of type 1 diabetes. Advances in Immunology. 100: 151-75. PMID 19111166 DOI: 10.1016/S0065-2776(08)00806-7 |
0.427 |
|
| 2008 |
Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA, Todd JA, et al. Shared and distinct genetic variants in type 1 diabetes and celiac disease. The New England Journal of Medicine. 359: 2767-77. PMID 19073967 DOI: 10.1056/Nejmoa0807917 |
0.484 |
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| 2008 |
Maier LM, Howlett SK, Rainbow KM, Clark J, Howson JMM, Todd JA, Wicker LS. NKG2D-RAE-1 receptor-ligand variation does not account for the NK cell defect in nonobese diabetic mice. Journal of Immunology. 181: 7073-7080. PMID 18981127 DOI: 10.4049/Jimmunol.181.10.7073 |
0.315 |
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| 2008 |
Cooper JD, Smyth DJ, Smiles AM, Plagnol V, Walker NM, Allen JE, Downes K, Barrett JC, Healy BC, Mychaleckyj JC, Warram JH, Todd JA. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nature Genetics. 40: 1399-401. PMID 18978792 DOI: 10.1038/Ng.249 |
0.388 |
|
| 2008 |
Dunger DB, Todd JA. Prevention of type 1 diabetes: what next? The Lancet. 372: 1710-1711. PMID 18814907 DOI: 10.1016/S0140-6736(08)61310-0 |
0.407 |
|
| 2008 |
Plagnol V, Uz E, Wallace C, Stevens H, Clayton D, Ozcelik T, Todd JA. Extreme clonality in lymphoblastoid cell lines with implications for allele specific expression analyses. Plos One. 3: e2966. PMID 18698422 DOI: 10.1371/Journal.Pone.0002966 |
0.324 |
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| 2008 |
Concannon P, Onengut-Gumuscu S, Todd JA, Smyth DJ, Pociot F, Bergholdt R, Akolkar B, Erlich HA, Hilner JE, Julier C, Morahan G, Nerup J, Nierras CR, Chen WM, Rich SS, et al. A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes. 57: 2858-61. PMID 18647951 DOI: 10.2337/Db08-0753 |
0.479 |
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| 2008 |
Rainbow DB, Esposito L, Howlett SK, Hunter KM, Todd JA, Peterson LB, Wicker LS. Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species. Biochemical Society Transactions. 36: 312-5. PMID 18481948 DOI: 10.1042/Bst0360312 |
0.476 |
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| 2008 |
Field SF, Nejentsev S, Walker NM, Howson JM, Godfrey LM, Jolley JD, Hardy MP, Todd JA. Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes. Diabetes. 57: 1753-6. PMID 18332098 DOI: 10.2337/Db07-1402 |
0.496 |
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| 2008 |
Vella A, Bouatia-Naji N, Heude B, Cooper JD, Lowe CE, Petry C, Ring SM, Dunger DB, Todd JA, Ong KK. Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes Diabetologia. 51: 811-815. PMID 18317720 DOI: 10.1007/S00125-008-0970-7 |
0.428 |
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| 2008 |
Smyth DJ, Cooper JD, Howson JM, Walker NM, Plagnol V, Stevens H, Clayton DG, Todd JA. PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes. Diabetes. 57: 1730-7. PMID 18305142 DOI: 10.2337/Db07-1131 |
0.456 |
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| 2008 |
Erlich H, Valdes AM, Noble J, Carlson JA, Varney M, Concannon P, Mychaleckyj JC, Todd JA, Bonella P, Fear AL, Lavant E, Louey A, Moonsamy P. HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: Analysis of the Type 1 Diabetes Genetics Consortium Families Diabetes. 57: 1084-1092. PMID 18252895 DOI: 10.2337/Db07-1331 |
0.494 |
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| 2008 |
Horton R, Gibson R, Coggill P, Miretti M, Allcock RJ, Almeida J, Forbes S, Gilbert JG, Halls K, Harrow JL, Hart E, Howe K, Jackson DK, Palmer S, Roberts AN, ... Todd JA, et al. Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics. 60: 1-18. PMID 18193213 DOI: 10.1007/S00251-007-0262-2 |
0.389 |
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| 2008 |
Raj S, Smyth D, Howson JM, Cooper J, Field S, Plagnol V, Walker N, Todd J. Sa.81. Do Type 1 and Type 2 Diabetes Have a Common Genetic Basis? Clinical Immunology. 127: S107. DOI: 10.1016/J.Clim.2008.03.302 |
0.423 |
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| 2007 |
Hunter K, Rainbow D, Plagnol V, Todd JA, Peterson LB, Wicker LS. Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes. Journal of Immunology (Baltimore, Md. : 1950). 179: 8341-9. PMID 18056379 DOI: 10.4049/Jimmunol.179.12.8341 |
0.473 |
|
| 2007 |
Cooper JD, Smyth DJ, Bailey R, Payne F, Downes K, Godfrey LM, Masters J, Zeitels LR, Vella A, Walker NM, Todd JA. The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes. Bmc Medical Genetics. 8: 71. PMID 18045485 DOI: 10.1186/1471-2350-8-71 |
0.487 |
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| 2007 |
Nejentsev S, Howson JM, Walker NM, Szeszko J, Field SF, Stevens HE, Reynolds P, Hardy M, King E, Masters J, Hulme J, Maier LM, Smyth D, Bailey R, Cooper JD, ... Todd JA, et al. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature. 450: 887-92. PMID 18004301 DOI: 10.1038/Nature06406 |
0.474 |
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| 2007 |
Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, Todd JA, Donnelly P, Barrett JC, et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genetics. 39: 1329-37. PMID 17952073 DOI: 10.1038/Ng.2007.17 |
0.374 |
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| 2007 |
Burke DF, Worth CL, Priego EM, Cheng T, Smink LJ, Todd JA, Blundell TL. Genome bioinformatic analysis of nonsynonymous SNPs. Bmc Bioinformatics. 8: 301. PMID 17708757 DOI: 10.1186/1471-2105-8-301 |
0.37 |
|
| 2007 |
Lowe CE, Cooper JD, Brusko T, Walker NM, Smyth DJ, Bailey R, Bourget K, Plagnol V, Field S, Atkinson M, Clayton DG, Wicker LS, Todd JA. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nature Genetics. 39: 1074-82. PMID 17676041 DOI: 10.1038/Ng2102 |
0.478 |
|
| 2007 |
Field SF, Howson JM, Walker NM, Dunger DB, Todd JA. Analysis of the obesity gene FTO in 14,803 type 1 diabetes cases and controls. Diabetologia. 50: 2218-20. PMID 17657473 DOI: 10.1007/S00125-007-0767-0 |
0.325 |
|
| 2007 |
Bailey R, Cooper JD, Zeitels L, Smyth DJ, Yang JHM, Walker NM, Hyppönen E, Dunger DB, Ramos-Lopez E, Badenhoop K, Nejentsev S, Todd JA. Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes Diabetes. 56: 2616-2621. PMID 17606874 DOI: 10.2337/Db07-0652 |
0.453 |
|
| 2007 |
Simmonds MJ, Howson JMM, Heward JM, Carr-Smith J, Franklyn JA, Todd JA, Gough SCL. A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect Human Molecular Genetics. 16: 2149-2153. PMID 17597093 DOI: 10.1093/Hmg/Ddm165 |
0.32 |
|
| 2007 |
Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, Todd JA, Donnelly P, Barrett JC, Davison D, Easton D, et al. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature. 447: 661-678. PMID 17554300 DOI: 10.1038/Nature05911 |
0.433 |
|
| 2007 |
Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JH, et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genetics. 39: 857-64. PMID 17554260 DOI: 10.1038/Ng2068 |
0.428 |
|
| 2007 |
Nejentsev S, Smink LJ, Smyth D, Bailey R, Lowe CE, Payne F, Masters J, Godfrey L, Lam A, Burren O, Stevens H, Nutland S, Walker NM, Smith A, Twells R, ... Todd JA, et al. Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11. Bmc Genetics. 8: 24. PMID 17509149 DOI: 10.1186/1471-2156-8-24 |
0.44 |
|
| 2007 |
Brand OJ, Lowe CE, Heward JM, Franklyn JA, Cooper JD, Todd JA, Gough SC. Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs. Clinical Endocrinology. 66: 508-12. PMID 17371467 DOI: 10.1111/J.1365-2265.2007.02762.X |
0.436 |
|
| 2007 |
Howson JMM, Dunger DB, Nutland S, Stevens H, Wicker LS, Todd JA. A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene Diabetologia. 50: 741-746. PMID 17334650 DOI: 10.1007/S00125-007-0603-6 |
0.441 |
|
| 2007 |
Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, ... Todd JA, et al. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nature Genetics. 39: 329-37. PMID 17277778 DOI: 10.1038/Ng1958 |
0.314 |
|
| 2007 |
Payne F, Cooper JD, Walker NM, Lam AC, Smink LJ, Nutland S, Stevens HE, Hutchings J, Todd JA. Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes. Journal of Leukocyte Biology. 81: 581-3. PMID 17209142 DOI: 10.1189/Jlb.0906577 |
0.418 |
|
| 2007 |
Hulbert EM, Smink LJ, Adlem EC, Allen JE, Burdick DB, Burren OS, Cassen VM, Cavnor CC, Dolman GE, Flamez D, Friery KF, Healy BC, Killcoyne SA, Kutlu B, Schuilenburg H, ... Todd JA, et al. T1DBase: integration and presentation of complex data for type 1 diabetes research. Nucleic Acids Research. 35: D742-6. PMID 17169983 DOI: 10.1093/Nar/Gkl933 |
0.35 |
|
| 2007 |
Szeszko JS, Healy B, Stevens H, Balabanova Y, Drobniewski F, Todd JA, Nejentsev S. Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis Human Genetics. 121: 155-160. PMID 17149599 DOI: 10.1007/S00439-006-0293-Z |
0.347 |
|
| 2007 |
Hulbert EM, Smink LJ, Adlem EC, Allen JE, Burdick DB, Burren OS, Cassen VM, Cavnor CC, Dolman GE, Flamez D, Friery KF, Healy BC, Killcoyne SA, Kutlu B, Schuilenburg H, ... Todd JA, et al. T1DBase: integration and presentation of complex data for type 1 diabetes research (vol 35, pg D742, 2007) Nucleic Acids Research. 35: 6338-6338. DOI: 10.1093/Nar/Gkm715 |
0.355 |
|
| 2007 |
Fung E, Todd JA, Wicker LS. Monocyte Immunophenotypes in Type 1Diabetes Clinical Immunology. 123. DOI: 10.1016/J.Clim.2007.03.224 |
0.41 |
|
| 2007 |
Plagnol V, Clayton D, Dunger D, Downes K, Leung H, Smyth D, Stevens H, Walker N, Todd J. A Genome-wide Assessment of the Genetic Basis of Type 1 Diabetes Clinical Immunology. 123. DOI: 10.1016/J.Clim.2007.03.025 |
0.419 |
|
| 2006 |
Rich SS, Concannon P, Erlich H, Julier C, Morahan G, Nerup J, Pociot F, Todd JA. The Type 1 Diabetes Genetics Consortium. Annals of the New York Academy of Sciences. 1079: 1-8. PMID 17130525 DOI: 10.1196/Annals.1375.001 |
0.453 |
|
| 2006 |
Field SF, Howson JM, Smyth DJ, Walker NM, Dunger DB, Todd JA. Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects. Diabetologia. 50: 212-3. PMID 17063324 DOI: 10.1007/S00125-006-0506-Y |
0.489 |
|
| 2006 |
de Bakker PI, McVean G, Sabeti PC, Miretti MM, Green T, Marchini J, Ke X, Monsuur AJ, Whittaker P, Delgado M, Morrison J, Richardson A, Walsh EC, Gao X, Galver L, ... Todd JA, et al. A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nature Genetics. 38: 1166-72. PMID 16998491 DOI: 10.1038/Ng1885 |
0.412 |
|
| 2006 |
Todd JA. Statistical false positive or true disease pathway? Nature Genetics. 38: 731-733. PMID 16804532 DOI: 10.1038/Ng0706-731 |
0.456 |
|
| 2006 |
Maier LM, Howson JM, Walker N, Spickett GP, Jones RW, Ring SM, McArdle WL, Lowe CE, Bailey R, Payne F, Todd JA, Strachan DP. Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes. The Journal of Allergy and Clinical Immunology. 117: 1306-13. PMID 16750991 DOI: 10.1016/J.Jaci.2005.12.1354 |
0.462 |
|
| 2006 |
Smyth DJ, Cooper JD, Bailey R, Field S, Burren O, Smink LJ, Guja C, Ionescu-Tirgoviste C, Widmer B, Dunger DB, Savage DA, Walker NM, Clayton DG, Todd JA. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nature Genetics. 38: 617-9. PMID 16699517 DOI: 10.1038/Ng1800 |
0.459 |
|
| 2006 |
Smyth DJ, Cooper JD, Lowe CE, Nutland S, Walker NM, Clayton DG, Todd JA. No evidence for association of OAS1 with type 1 diabetes in unaffected siblings or type 1 diabetic cases. Diabetes. 55: 1525-8. PMID 16644715 DOI: 10.2337/Db05-1452 |
0.488 |
|
| 2006 |
Taniguchi H, Lowe CE, Cooper JD, Smyth DJ, Bailey R, Nutland S, Healy BC, Lam AC, Burren O, Walker NM, Smink LJ, Wicker LS, Todd JA. Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes. Bmc Genetics. 7: 22. PMID 16626483 DOI: 10.1186/1471-2156-7-22 |
0.468 |
|
| 2006 |
Smyth DJ, Howson JMM, Payne F, Maier LM, Bailey R, Holland K, Lowe CE, Cooper JD, Hulme JS, Vella A, Dahlman I, Lam AC, Nutland S, Walker NM, Twells RCJ, Todd JA, et al. Analysis of polymorphisms in 16 genes in type I diabetes that have been associated with other immune-mediated diseases Bmc Medical Genetics. 7. PMID 16519819 DOI: 10.1186/1471-2350-7-20 |
0.452 |
|
| 2006 |
Morris GA, Lowe CE, Cooper JD, Payne F, Vella A, Godfrey L, Hulme JS, Walker NM, Healy BC, Lam AC, Lyons PA, Todd JA. Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes. Bmc Genetics. 7: 12. PMID 16504056 DOI: 10.1186/1471-2156-7-12 |
0.462 |
|
| 2006 |
Pask R, Cooper JD, Walker NM, Nutland S, Hutchings J, Dunger DB, Nejentsev S, Todd JA. No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility. Diabetes-Metabolism Research and Reviews. 22: 356-360. PMID 16453382 DOI: 10.1002/Dmrr.628 |
0.396 |
|
| 2006 |
Szeszko JS, Howson JMM, Cooper JD, Walker NM, Twells RCJ, Stevens HE, Nutland SL, Todd JA. Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing Diabetes. 55: 559-562. PMID 16443795 DOI: 10.2337/Diabetes.55.02.06.Db05-0826 |
0.482 |
|
| 2006 |
Traherne JA, Horton R, Roberts AN, Miretti MM, Hurles ME, Stewart CA, Ashurst JL, Atrazhev AM, Coggill P, Palmer S, Almeida J, Sims S, Wilming LG, Rogers J, de Jong PJ, ... Todd JA, et al. Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. Plos Genetics. 2: e9. PMID 16440057 DOI: 10.1371/Journal.Pgen.0020009 |
0.418 |
|
| 2006 |
Barber MJ, Todd JA, Cordell HJ. A multimarker regression-based test of linkage for affected sib-pairs at two linked loci. Genetic Epidemiology. 30: 191-208. PMID 16385470 DOI: 10.1002/Gepi.20137 |
0.379 |
|
| 2005 |
Wicker LS, Clark J, Fraser HI, Garner VE, Gonzalez-Munoz A, Healy B, Howlett S, Hunter K, Rainbow D, Rosa RL, Smink LJ, Todd JA, Peterson LB. Type 1 diabetes genes and pathways shared by humans and NOD mice. Journal of Autoimmunity. 25: 29-33. PMID 16257508 DOI: 10.1016/J.Jaut.2005.09.009 |
0.437 |
|
| 2005 |
Clayton DG, Walker NM, Smyth DJ, Pask R, Cooper JD, Maier LM, Smink LJ, Lam AC, Ovington NR, Stevens HE, Nutland S, Howson JM, Faham M, Moorhead M, Jones HB, ... Todd JA, et al. Population structure, differential bias and genomic control in a large-scale, case-control association study. Nature Genetics. 37: 1243-6. PMID 16228001 DOI: 10.1038/Ng1653 |
0.353 |
|
| 2005 |
Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Pociot F, Todd JA, Rich SS. Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. Diabetes. 54: 2995-3001. PMID 16186404 DOI: 10.2337/Diabetes.54.10.2995 |
0.459 |
|
| 2005 |
Maier LM, Cooper JD, Walker N, Smyth DJ, Todd JA. Comment to: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900-905. Diabetologia. 48: 2180-2182. PMID 16132953 DOI: 10.1007/S00125-005-1906-0 |
0.363 |
|
| 2005 |
Wicker LS, Moule CL, Fraser H, Penha-Goncalves C, Rainbow D, Garner VE, Chamberlain G, Hunter K, Howlett S, Clark J, Gonzalez-Munoz A, Cumiskey AM, Tiffen P, Howson J, Healy B, ... Todd JA, et al. Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse. Novartis Foundation Symposium. 267: 57-65; discussion 65. PMID 15999801 DOI: 10.1002/047002139X.Ch6 |
0.493 |
|
| 2005 |
Cannons JL, Chamberlain G, Howson J, Smink LJ, Todd JA, Peterson LB, Wicker LS, Watts TH. Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetes. Journal of Autoimmunity. 25: 13-20. PMID 15998581 DOI: 10.1016/J.Jaut.2005.04.007 |
0.428 |
|
| 2005 |
Howson JMM, Barratt BJ, Todd JA, Cordell HJ. Comparison of population- and family-based methods for genetic association analysis in the presence of interacting loci. Genetic Epidemiology. 29: 51-67. PMID 15892093 DOI: 10.1002/Gepi.20077 |
0.379 |
|
| 2005 |
Petry CJ, Ong KK, Barratt BJ, Wingate D, Cordell HJ, Ring SM, Pembrey ME, Reik W, Todd JA, Dunger DB. Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans Bmc Genetics. 6: 22-22. PMID 15885138 DOI: 10.1186/1471-2156-6-22 |
0.344 |
|
| 2005 |
Payne F, Smyth DJ, Pask R, Cooper JD, Masters J, Wang WY, Godfrey LM, Bowden G, Szeszko J, Smink LJ, Lam AC, Burren O, Walker NM, Nutland S, Rance H, ... Todd JA, et al. No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetes. Biochemical and Biophysical Research Communications. 331: 435-41. PMID 15850778 DOI: 10.1016/J.Bbrc.2005.03.203 |
0.468 |
|
| 2005 |
Vella A, Cooper JD, Lowe CE, Walker N, Nutland S, Widmer B, Jones R, Ring SM, McArdle W, Pembrey ME, Strachan DP, Dunger DB, Twells RC, Clayton DG, Todd JA. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. American Journal of Human Genetics. 76: 773-9. PMID 15776395 DOI: 10.1086/429843 |
0.461 |
|
| 2005 |
Maier LM, Smyth DJ, Vella A, Payne F, Cooper JD, Pask R, Lowe C, Hulme J, Smink LJ, Fraser H, Moule C, Hunter KM, Chamberlain G, Walker N, Nutland S, ... Todd JA, et al. Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes. Bmc Genetics. 6: 9. PMID 15720714 DOI: 10.1186/1471-2156-6-9 |
0.467 |
|
| 2005 |
Wang WY, Barratt BJ, Clayton DG, Todd JA. Genome-wide association studies: theoretical and practical concerns. Nature Reviews. Genetics. 6: 109-18. PMID 15716907 DOI: 10.1038/Nrg1522 |
0.365 |
|
| 2005 |
Li-Sucholeiki XC, Tomita-Mitchell A, Arnold K, Glassner BJ, Thompson T, Murthy JV, Berk L, Lange C, Leong-Morgenthaler PM, MacDougall D, Munro J, Cannon D, Mistry T, Miller A, Deka C, ... Todd JA, et al. Detection and frequency estimation of rare variants in pools of genomic DNA from large populations using mutational spectrometry. Mutation Research. 570: 267-80. PMID 15708585 DOI: 10.1016/J.Mrfmmm.2004.11.004 |
0.369 |
|
| 2005 |
Smyth DJ, Howson JMM, Lowe CE, Walker NM, Lam AC, Nutland S, Hutchings J, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tîrgoviste C, Undlien DE, Rønningen KS, Savage D, Dunger DB, ... Todd JA, et al. Assessing the validity of the association between the SUM04 M55V variant and risk of type 1 diabetes [2] Nature Genetics. 37: 110-111. PMID 15678134 DOI: 10.1038/Ng0205-110 |
0.416 |
|
| 2005 |
Maier LM, Chapman J, Howson JM, Clayton DG, Pask R, Strachan DP, McArdle WL, Twells RC, Todd JA. No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes. American Journal of Human Genetics. 76: 517-21. PMID 15660293 DOI: 10.1086/428387 |
0.374 |
|
| 2005 |
Smink LJ, Helton EM, Healy BC, Cavnor CC, Lam AC, Flamez D, Burren OS, Wang Y, Dolman GE, Burdick DB, Everett VH, Glusman G, Laneri D, Rowen L, Schuilenburg H, ... Todd JA, et al. T1DBase, a community web-based resource for type 1 diabetes research. Nucleic Acids Research. 33: D544-9. PMID 15608258 DOI: 10.1093/Nar/Gki095 |
0.399 |
|
| 2005 |
Simmonds MJ, Howson JMM, Heward JM, Cordell HJ, Foxall H, Carr-Smith J, Gibson SM, Walker N, Tomer Y, Franklyn JA, Todd JA, Gough SCL. Regression mapping of association between the human leukocyte antigen region and Graves disease American Journal of Human Genetics. 76: 157-163. PMID 15558498 DOI: 10.1086/426947 |
0.376 |
|
| 2004 |
Veitenhansl M, Stegner K, Hierl FX, Dieterle C, Feldmeier H, Gutt B, Landgraf R, Garrow AP, Vileikyte L, Findlow A, Waterman C, Boulton AJ, Shankhdhar K, Shankhdhar L, Shankhdhar U, ... Todd JA, et al. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004. Diabetologia. 47: A1-A464. PMID 27770180 DOI: 10.1007/Bf03375463 |
0.404 |
|
| 2004 |
Burren OS, Healy BC, Lam AC, Schuilenburg H, Dolman GE, Everett VH, Laneri D, Nutland S, Rance HE, Payne F, Smyth D, Lowe C, Barratt BJ, Twells RCJ, Rainbow DB, ... Todd JA, et al. Development of an integrated genome informatics, data management and workflow infrastructure: A toolbox for the study of complex disease genetics Human Genomics. 1: 98-109. PMID 15601538 DOI: 10.1186/1479-7364-1-2-98 |
0.392 |
|
| 2004 |
Motzo C, Contu D, Cordell HJ, Lampis R, Congia M, Marrosu MG, Todd JA, Devoto M, Cucca F. Heterogeneity in the magnitude of the insulin gene effect on HLA risk in type 1 diabetes. Diabetes. 53: 3286-3291. PMID 15561961 DOI: 10.2337/Diabetes.53.12.3286 |
0.463 |
|
| 2004 |
Smyth D, Cooper JD, Collins JE, Heward JM, Franklyn JA, Howson JM, Vella A, Nutland S, Rance HE, Maier L, Barratt BJ, Guja C, Ionescu-Tîrgoviste C, Savage DA, Dunger DB, ... Todd JA, et al. Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes. 53: 3020-3. PMID 15504986 DOI: 10.2337/Diabetes.53.11.3020 |
0.484 |
|
| 2004 |
Nejentsev S, Cooper JD, Godfrey L, Howson JM, Rance H, Nutland S, Walker NM, Guja C, Ionescu-Tirgovi?te C, Savage DA, Undlien DE, Rønningen KS, Tuomilehto-Wolf E, Tuomilehto J, Gillespie KM, ... Todd JA, et al. Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes. Diabetes. 53: 2709-12. PMID 15448105 DOI: 10.2337/Diabetes.53.10.2709 |
0.444 |
|
| 2004 |
Hulme JS, Barratt BJ, Twells RCJ, Cooper JD, Lowe CE, Howson JMM, Lam AC, Smink LJ, Savage DA, Undlien DE, Guja C, Ionescu-Tîrgovişte C, Tuomilehto-Wolf E, Tuomilehto J, Todd JA. Association analysis of the lymphocyte-specific protein tyrosine kinase (LCK) gene in type 1 diabetes Diabetes. 53: 2479-2482. PMID 15331563 DOI: 10.2337/Diabetes.53.9.2479 |
0.495 |
|
| 2004 |
Koarada S, Wu Y, Fertig N, Sass DA, Nalesnik M, Todd JA, Lyons PA, Fenyk-Melody J, Rainbow DB, Wicker LS, Peterson LB, Ridgway WM. Genetic control of autoimmunity: protection from diabetes, but spontaneous autoimmune biliary disease in a nonobese diabetic congenic strain. Journal of Immunology (Baltimore, Md. : 1950). 173: 2315-23. PMID 15294944 DOI: 10.4049/Jimmunol.173.4.2315 |
0.444 |
|
| 2004 |
Lambert AP, Gillespie KM, Thomson G, Cordell HJ, Todd JA, Gale EA, Bingley PJ. Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom. The Journal of Clinical Endocrinology and Metabolism. 89: 4037-43. PMID 15292346 DOI: 10.1210/Jc.2003-032084 |
0.437 |
|
| 2004 |
Pask R, Rance HE, Barratt BJ, Nutland S, Smyth DJ, Sebastian M, Twells RC, Smith A, Lam AC, Smink LJ, Walker NM, Todd JA. Investigating the utility of combining phi29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray genotyping. Bmc Biotechnology. 4: 15. PMID 15279678 DOI: 10.1186/1472-6750-4-15 |
0.336 |
|
| 2004 |
Guja C, Guja L, Nutland S, Rance H, Sebastien M, Todd JA, Ionescu-Tirgoviste C. Type 1 diabetes genetic susceptibility encoded by HLA DQB1 genes in Romania. Journal of Cellular and Molecular Medicine. 8: 249-256. PMID 15256073 DOI: 10.1111/J.1582-4934.2004.Tb00280.X |
0.495 |
|
| 2004 |
Zavattari P, Deidda E, Pitzalis M, Zoa B, Moi L, Lampis R, Contu D, Motzo C, Frongia P, Angius E, Maioli M, Todd JA, Cucca F. No association between variation of the FOXP3 gene and common type 1 diabetes in the Sardinian population. Diabetes. 53: 1911-1914. PMID 15220219 DOI: 10.2337/Diabetes.53.7.1911 |
0.498 |
|
| 2004 |
Barratt BJ, Payne F, Lowe CE, Hermann R, Healy BC, Harold D, Concannon P, Gharani N, McCarthy MI, Olavesen MG, McCormack R, Guja C, Ionescu-Tîrgovi?te C, Undlien DE, Rønningen KS, ... Todd JA, et al. Remapping the insulin gene/IDDM2 locus in type 1 diabetes. Diabetes. 53: 1884-9. PMID 15220214 DOI: 10.2337/Diabetes.53.7.1884 |
0.465 |
|
| 2004 |
Wicker LS, Chamberlain G, Hunter K, Rainbow D, Howlett S, Tiffen P, Clark J, Gonzalez-Munoz A, Cumiskey AM, Rosa RL, Howson JM, Smink LJ, Kingsnorth A, Lyons PA, Gregory S, ... Todd JA, et al. Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. Journal of Immunology (Baltimore, Md. : 1950). 173: 164-73. PMID 15210771 DOI: 10.4049/Jimmunol.173.1.164 |
0.485 |
|
| 2004 |
Nejentsev S, Godfrey L, Snook H, Rance H, Nutland S, Walker NM, Lam AC, Guja C, Ionescu-Tirgoviste C, Undlien DE, Rønningen KS, Tuomilehto-Wolf E, Tuomilehto J, Newport MJ, Clayton DG, Todd JA, et al. Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene. Human Molecular Genetics. 13: 1633-9. PMID 15175274 DOI: 10.1093/Hmg/Ddh169 |
0.35 |
|
| 2004 |
Koeleman BPC, Lie BA, Undlien DE, Dudbridge F, Thorsby E, Vries RRPD, Cucca F, Roep BO, Giphart MJ, Todd JA. Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease. Genes and Immunity. 5: 381-388. PMID 15164102 DOI: 10.1038/Sj.Gene.6364106 |
0.472 |
|
| 2004 |
Stewart CA, Horton R, Allcock RJ, Ashurst JL, Atrazhev AM, Coggill P, Dunham I, Forbes S, Halls K, Howson JM, Humphray SJ, Hunt S, Mungall AJ, Osoegawa K, Palmer S, ... Todd JA, et al. Complete MHC haplotype sequencing for common disease gene mapping. Genome Research. 14: 1176-87. PMID 15140828 DOI: 10.1101/Gr.2188104 |
0.394 |
|
| 2004 |
Collins JE, Heward JM, Nithiyananthan R, Nejentsev S, Todd JA, Franklyn JA, Gough SC. Lack of association of the vitamin D receptor gene with Graves' disease in UK Caucasians. Clinical Endocrinology. 60: 618-24. PMID 15104566 DOI: 10.1111/J.1365-2265.2004.02015.X |
0.414 |
|
| 2004 |
Tait KF, Marshall T, Berman J, Carr-Smith J, Rowe B, Todd JA, Bain SC, Barnett AH, Gough SC. Clustering of autoimmune disease in parents of siblings from the Type 1 diabetes Warren repository. Diabetic Medicine : a Journal of the British Diabetic Association. 21: 358-62. PMID 15049939 DOI: 10.1111/J.1464-5491.2004.01162.X |
0.398 |
|
| 2004 |
Awomoyi AA, Nejentsev S, Richardson A, Hull J, Koch O, Podinovskaia M, Todd JA, McAdam KP, Blackwell JM, Kwiatkowski D, Newport MJ. No association between interferon-gamma receptor-1 gene polymorphism and pulmonary tuberculosis in a Gambian population sample. Thorax. 59: 291-4. PMID 15047947 DOI: 10.1136/Thx.2003.013029 |
0.313 |
|
| 2004 |
Vella A, Howson JMM, Barratt BJ, Twells RCJ, Rance HE, Nutland S, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE, Ronningen KS, Guja C, Ionescu-Tirgoviste C, Savage DA, Todd JA. Lack of Association of the Ala45Thr Polymorphism and Other Common Variants of the NeuroD Gene With Type 1 Diabetes Diabetes. 53: 1158-1161. PMID 15047635 DOI: 10.2337/Diabetes.53.4.1158 |
0.502 |
|
| 2004 |
Ong KK, Petry CJ, Barratt BJ, Ring S, Cordell HJ, Wingate DL, Pembrey ME, Todd JA, Dunger DB. Maternal-fetal interactions and birth order influence insulin variable number of tandem repeats allele class associations with head size at birth and childhood weight gain. Diabetes. 53: 1128-33. PMID 15047631 DOI: 10.2337/Diabetes.53.4.1128 |
0.31 |
|
| 2004 |
Lowe CE, Cooper JD, Chapman JM, Barratt BJ, Twells RC, Green EA, Savage DA, Guja C, Ionescu-Tîrgovi?te C, Tuomilehto-Wolf E, Tuomilehto J, Todd JA, Clayton DG. Cost-effective analysis of candidate genes using htSNPs: a staged approach. Genes and Immunity. 5: 301-5. PMID 15029236 DOI: 10.1038/Sj.Gene.6364064 |
0.427 |
|
| 2004 |
Tait KF, Collins JE, Heward JM, Eaves I, Snook H, Franklyn JA, Barnett AH, Todd JA, Maranian M, Compston A, Sawcer S, Gough SC. Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on autoimmunity. Diabetic Medicine : a Journal of the British Diabetic Association. 21: 267-70. PMID 15008838 DOI: 10.1111/J.1464-5491.2004.01129.X |
0.482 |
|
| 2004 |
Eftychi C, Howson JMM, Barratt BJ, Vella A, Payne F, Smyth DJ, Twells RCJ, Walker NM, Rance HE, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE, Rønningen KS, Guja C, Ionescu-Tı̂irgovişte C, ... Todd JA, et al. Analysis of the Type 2 Diabetes-Associated Single Nucleotide Polymorphisms in the Genes IRS1, KCNJ11, and PPARG2 in Type 1 Diabetes Diabetes. 53: 870-873. PMID 14988278 DOI: 10.2337/Diabetes.53.3.870 |
0.496 |
|
| 2004 |
Marguerat S, Wang WYS, Todd JA, Conrad B. Association of human endogenous retrovirus K-18 polymorphisms with type 1 diabetes Diabetes. 53: 852-854. PMID 14988274 DOI: 10.2337/Diabetes.53.3.852 |
0.444 |
|
| 2004 |
Payne F, Smyth DJ, Pask R, Barratt BJ, Cooper JD, Twells RC, Walker NM, Lam AC, Smink LJ, Nutland S, Rance HE, Todd JA. Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb. Diabetes. 53: 505-9. PMID 14747305 DOI: 10.2337/Diabetes.53.2.505 |
0.497 |
|
| 2003 |
Nejentsev S, Guja C, McCormack R, Cooper J, Howson JM, Nutland S, Rance H, Walker N, Undlien D, Ronningen KS, Tuomilehto-Wolf E, Tuomilehto J, Ionescu-Tirgoviste C, Gale EA, Bingley PJ, ... Todd JA, et al. Association of intercellular adhesion molecule-1 gene with type 1 diabetes. Lancet (London, England). 362: 1723-4. PMID 14643123 DOI: 10.1016/S0140-6736(03)14847-7 |
0.447 |
|
| 2003 |
Chapman JM, Cooper JD, Todd JA, Clayton DG. Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Human Heredity. 56: 18-31. PMID 14614235 DOI: 10.1159/000073729 |
0.408 |
|
| 2003 |
Maier LM, Twells RC, Howson JM, Lam AC, Clayton DG, Smyth DJ, Savage D, Carson D, Patterson CC, Smink LJ, Walker NM, Burren OS, Nutland S, Rance H, Tuomilehto-Wolf E, ... Todd JA, et al. Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene. Genes and Immunity. 4: 469-75. PMID 14551599 DOI: 10.1038/Sj.Gene.6364007 |
0.445 |
|
| 2003 |
Wang WYS, Todd JA. The usefulness of different density SNP maps for disease association studies of common variants Human Molecular Genetics. 12: 3145-3149. PMID 14532327 DOI: 10.1093/Hmg/Ddg337 |
0.359 |
|
| 2003 |
Penha-Gonçalves C, Moule C, Smink LJ, Howson J, Gregory S, Rogers J, Lyons PA, Suttie JJ, Lord CJ, Peterson LB, Todd JA, Wicker LS. Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. Diabetes. 52: 1551-6. PMID 12765969 DOI: 10.2337/Diabetes.52.6.1551 |
0.394 |
|
| 2003 |
Walter M, Albert E, Conrad M, Keller E, Hummel M, Ferber K, Barratt BJ, Todd JA, Ziegler A-, Bonifacio E. IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity Diabetologia. 46: 712-720. PMID 12750767 DOI: 10.1007/S00125-003-1082-Z |
0.464 |
|
| 2003 |
Twells RC, Mein CA, Phillips MS, Hess JF, Veijola R, Gilbey M, Bright M, Metzker M, Lie BA, Kingsnorth A, Gregory E, Nakagawa Y, Snook H, Wang WY, Masters J, ... Todd JA, et al. Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene. Genome Research. 13: 845-55. PMID 12727905 DOI: 10.1101/Gr.563703 |
0.312 |
|
| 2003 |
Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, ... Todd JA, et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature. 423: 506-11. PMID 12724780 DOI: 10.1038/Nature01621 |
0.463 |
|
| 2003 |
Twells RC, Mein CA, Payne F, Veijola R, Gilbey M, Bright M, Timms A, Nakagawa Y, Snook H, Nutland S, Rance HE, Carr P, Dudbridge F, Cordell HJ, Cooper J, ... Todd JA, et al. Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes. Human Genetics. 113: 99-105. PMID 12700977 DOI: 10.1007/S00439-003-0940-6 |
0.429 |
|
| 2003 |
Johansson S, Lie BA, Todd JA, Pociot F, Nerup J, Cambon-Thomsen A, Kockum I, Akselsen HE, Thorsby E, Undlien DE. Evidence of at least two type 1 diabetes susceptibility genes in the HLA complex distinct from HLA-DQB1, -DQA1 and –DRB1 Genes and Immunity. 4: 46-53. PMID 12595901 DOI: 10.1038/Sj.Gene.6363917 |
0.444 |
|
| 2003 |
Wang WYS, Cordell HJ, Todd JA. Association mapping of complex diseases in linked regions: estimation of genetic effects and feasibility of testing rare variants. Genetic Epidemiology. 24: 36-43. PMID 12508254 DOI: 10.1002/Gepi.10216 |
0.395 |
|
| 2003 |
Brook FA, Evans EP, Lord CJ, Lyons PA, Rainbow DB, Howlett SK, Wicker LS, Todd JA, Gardner RL. The derivation of highly germline-competent embryonic stem cells containing NOD-derived genome. Diabetes. 52: 205-8. PMID 12502514 DOI: 10.2337/Diabetes.52.1.205 |
0.381 |
|
| 2002 |
Barratt BJ, Payne F, Rance HE, Nutland S, Todd JA, Clayton DG. Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design. Annals of Human Genetics. 66: 393-405. PMID 12485472 DOI: 10.1017/S0003480002001252 |
0.306 |
|
| 2002 |
Contu D, Morelli LCC, Zavattari P, Lampis R, Angius E, Frongia P, Murru D, Maioli M, Francalacci P, Todd JA, Cucca F. Sex-Related Bias and Exclusion Mapping of the Nonrecombinant Portion of Chromosome Y in Human Type 1 Diabetes in the Isolated Founder Population of Sardinia Diabetes. 51: 3573-3576. PMID 12453916 DOI: 10.2337/Diabetes.51.12.3573 |
0.431 |
|
| 2002 |
Johnson GCL, Koeleman BPC, Todd JA. Limitations of stratifying sib‐pair data in common disease linkage studies: An example using chromosome 10p14‐10q11 in type 1 diabetes American Journal of Medical Genetics. 113: 158-166. PMID 12407706 DOI: 10.1002/Ajmg.10737 |
0.368 |
|
| 2002 |
Johnson GCL, Payne F, Nutland S, Stevens H, Tuomilehto-Wolf E, Tuomilehto J, Todd JA. A comprehensive, statistically powered analysis of GAD2 in type 1 diabetes. Diabetes. 51: 2866-2870. PMID 12196483 DOI: 10.2337/Diabetes.51.9.2866 |
0.515 |
|
| 2002 |
Guja C, Marshall S, Welsh K, Merriman M, Smith A, Todd JA, Ionescu-Tîrgoviste C. The study of CTLA-4 and vitamin D receptor polymorphisms in the Romanian type 1 diabetes population. Journal of Cellular and Molecular Medicine. 6: 75-81. PMID 12003670 DOI: 10.1111/J.1582-4934.2002.Tb00312.X |
0.459 |
|
| 2002 |
Eaves IA, Wicker LS, Ghandour G, Lyons PA, Peterson LB, Todd JA, Glynne RJ. Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: the NOD model of type 1 diabetes. Genome Research. 12: 232-43. PMID 11827943 DOI: 10.1101/gr.214102. Article published online before print in January 2002 |
0.325 |
|
| 2002 |
Dahlman I, Eaves IA, Kosoy R, Morrison VA, Heward J, Gough SC, Allahabadia A, Franklyn JA, Tuomilehto J, Tuomilehto-Wolf E, Cucca F, Guja C, Ionescu-Tirgoviste C, Stevens H, Carr P, ... Todd JA, et al. Parameters for reliable results in genetic association studies in common disease. Nature Genetics. 30: 149-50. PMID 11799396 DOI: 10.1038/Ng825 |
0.44 |
|
| 2002 |
Eaves IA, Wicker LS, Ghandour G, Lyons PA, Peterson LB, Todd JA, Glynne RJ. Combining Mouse Congenic Strains and Microarray Gene Expression Analyses to Study a Complex Trait: The NOD Model of Type 1 Diabetes Genome Research. 12: 232-243. DOI: 10.1101/Gr.214102 |
0.436 |
|
| 2001 |
Ionescu-Tîrgoviste C, Guja C, Herr M, Cucca E, Welsh K, Bunce M, Marshall S, Todd JA. Low frequency of HLA DRB1*03 - DQB1*02 and DQB1*0302 haplotypes in Romania is consistent with the country's low incidence of Type I diabetes. Diabetologia. 44: B60-6. PMID 11724419 DOI: 10.1007/Pl00002956 |
0.436 |
|
| 2001 |
Lyons PA, Armitage N, Lord CJ, Phillips MS, Todd JA, Peterson LB, Wicker LS. Mapping by genetic interaction: high-resolution congenic mapping of the type 1 diabetes loci Idd10 and Idd18 in the NOD mouse. Diabetes. 50: 2633-7. PMID 11679445 DOI: 10.2337/Diabetes.50.11.2633 |
0.446 |
|
| 2001 |
Cucca F, Lampis R, Congia M, Angius E, Nutland SL, Bain SC, Barnett AH, Todd JA. A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins Human Molecular Genetics. 10: 2025-2037. PMID 11590120 DOI: 10.1093/Hmg/10.19.2025 |
0.365 |
|
| 2001 |
Johnson GCL, Esposito L, Barratt BJ, Smith AN, Heward J, Genova GD, Ueda H, Cordell HJ, Eaves IA, Dudbridge F, Twells RCJ, Payne F, Hughes W, Nutland S, Stevens H, ... Todd JA, et al. Haplotype tagging for the identification of common disease genes Nature Genetics. 29: 233-237. PMID 11586306 DOI: 10.1038/Ng1001-233 |
0.411 |
|
| 2001 |
Todd JA, Wicker LS. Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models Immunity. 15: 387-395. PMID 11567629 DOI: 10.1016/S1074-7613(01)00202-3 |
0.405 |
|
| 2001 |
Cox NJ, Wapelhorst B, Morrison VA, Johnson L, Pinchuk L, Spielman RS, Todd JA, Concannon P. Seven Regions of the Genome Show Evidence of Linkage to Type 1 Diabetes in a Consensus Analysis of 767 Multiplex Families American Journal of Human Genetics. 69: 820-830. PMID 11507694 DOI: 10.1086/323501 |
0.424 |
|
| 2001 |
Twells RCJ, Metzker ML, Brown SD, Cox R, Garey C, Hammond H, Hey PJ, Levy E, Nakagawa Y, Philips MS, Todd JA, Hess JF. The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13 Genomics. 72: 231-242. PMID 11401438 DOI: 10.1006/Geno.2000.6492 |
0.388 |
|
| 2001 |
Todd JA. Tackling common disease Nature. 411: 537-539. PMID 11385552 DOI: 10.1038/35079223 |
0.308 |
|
| 2001 |
Cucca F, Dudbridge F, Loddo M, Mulargia A, Lampis R, Angius E, Virgiliis SD, Koeleman BPC, Bain SC, Barnett AH, Gilchrist FC, Cordell HJ, Welsh KI, Todd JA. The HLA-DPB1–Associated Component of the IDDM1 and Its Relationship to the Major Loci HLA-DQB1, -DQA1, and -DRB1 Diabetes. 50: 1200-1205. PMID 11334427 DOI: 10.2337/Diabetes.50.5.1200 |
0.408 |
|
| 2001 |
Zavattari P, Lampis R, Motzo C, Loddo M, Mulargia A, Whalen MB, Maioli M, Angius E, Todd JA, Cucca F. Conditional linkage disequilibrium analysis of a complex disease superlocus, IDDM1 in the HLA region, reveals the presence of independent modifying gene effects influencing the type 1 diabetes risk encoded by the major HLA-DQB1, -DRB1 disease loci Human Molecular Genetics. 10: 881-889. PMID 11285254 DOI: 10.1093/Hmg/10.8.881 |
0.498 |
|
| 2001 |
Lord CJ, Howlett S, Lyons PA, Peterson LB, Wicker LS, Todd JA. The murine type 1 diabetes loci, Idd1, Idd3, Idd5, Idd9, and Idd17/10/18, do not control thymic CD4-CD8-/TCRalphabeta+ deficiency in the nonobese diabetic mouse. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 12: 175-6. PMID 11210190 DOI: 10.1007/S003350010255 |
0.387 |
|
| 2001 |
Merriman TR, Cordell HJ, Eaves IA, Danoy PA, Coraddu F, Barber R, Cucca F, Broadley S, Sawcer S, Compston A, Wordsworth P, Shatford J, Laval S, Jirholt J, Holmdahl R, ... Todd JA, et al. Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases. Diabetes. 50: 184-94. PMID 11147786 DOI: 10.2337/Diabetes.50.1.184 |
0.421 |
|
| 2000 |
Gillespie KM, Valovin SJ, Saunby J, Hunter KM, Savage DA, Middleton D, Todd JA, Bingley PJ, Gale EA. HLA class II typing of whole genome amplified mouth swab DNA. Tissue Antigens. 56: 530-8. PMID 11169243 DOI: 10.1034/J.1399-0039.2000.560607.X |
0.328 |
|
| 2000 |
Zavattari P, Lampis R, Mulargia A, Loddo M, Angius E, Todd JA, Cucca F. Confirmation of the DRB1-DQB1 loci as the major component of IDDM1 in the isolated founder population of Sardinia Human Molecular Genetics. 9: 2967-2972. PMID 11115840 DOI: 10.1093/Hmg/9.20.2967 |
0.424 |
|
| 2000 |
Lampis R, Morelli L, Congia M, Macis MD, Mulargia A, Loddo M, De Virgiliis S, Marrosu MG, Todd JA, Cucca F. The inter-regional distribution of HLA class II haplotypes indicates the suitability of the Sardinian population for case-control association studies in complex diseases Human Molecular Genetics. 9: 2959-2965. PMID 11115839 DOI: 10.1093/Hmg/9.20.2959 |
0.389 |
|
| 2000 |
Zavattari P, Deidda E, Whalen MB, Lampis R, Mulargia A, Loddo M, Eaves IA, Mastio G, Todd JA, Cucca F. Major factors influencing linkage disequilibrium by analysis of different chromosome regions in distinct populations: demography, chromosome recombination frequency and selection Human Molecular Genetics. 9: 2947-2957. PMID 11115838 DOI: 10.1093/Hmg/9.20.2947 |
0.32 |
|
| 2000 |
Hill NJ, Lyons PA, Armitage N, Todd JA, Wicker LS, Peterson LB. NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans. Diabetes. 49: 1744-7. PMID 11016460 DOI: 10.2337/Diabetes.49.10.1744 |
0.456 |
|
| 2000 |
Figueroa DJ, Hess JF, Ky B, Brown SD, Sandig V, Hermanowski-Vosatka A, Twells RC, Todd JA, Austin CP. Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 48: 1357-68. PMID 10990489 DOI: 10.1177/002215540004801006 |
0.449 |
|
| 2000 |
Siegmund T, Armitage N, Wicker LS, Peterson LB, Todd JA, Lyons PA. Analysis of the mouse CD30 gene: a candidate for the NOD mouse type 1 diabetes locus Idd9.2. Diabetes. 49: 1612-6. PMID 10969850 DOI: 10.2337/Diabetes.49.9.1612 |
0.375 |
|
| 2000 |
Lyons PA, Hancock WW, Denny P, Lord CJ, Hill NJ, Armitage N, Siegmund T, Todd JA, Phillips MS, Hess JF, Chen SL, Fischer PA, Peterson LB, Wicker LS. The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137. Immunity. 13: 107-15. PMID 10933399 DOI: 10.1016/S1074-7613(00)00012-1 |
0.424 |
|
| 2000 |
Eaves IA, Merriman TR, Barber RA, Nutland S, Tuomilehto-Wolf E, Tuomilehto J, Cucca F, Todd JA. The genetically isolated populations of Finland and sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes. Nature Genetics. 25: 320-323. PMID 10888882 DOI: 10.1038/77091 |
0.35 |
|
| 2000 |
Podolin PL, Wilusz MB, Cubbon RM, Pajvani U, Lord CJ, Todd JA, Peterson LB, Wicker LS, Lyons PA. Differential glycosylation of interleukin 2, the molecular basis for the NOD Idd3 type 1 diabetes gene? Cytokine. 12: 477-82. PMID 10857762 DOI: 10.1006/Cyto.1999.0609 |
0.382 |
|
| 2000 |
Johnson GCL, Todd JA. Strategies in complex disease mapping Current Opinion in Genetics and Development. 10: 330-334. PMID 10826983 DOI: 10.1016/S0959-437X(00)00075-7 |
0.365 |
|
| 2000 |
Herr M, Dudbridge F, Zavattari P, Cucca F, Guja C, March R, Campbell RD, Barnett AH, Bain SC, Todd JA, Koeleman BP. Evaluation of fine mapping strategies for a multifactorial disease locus: systematic linkage and association analysis of IDDM1 in the HLA region on chromosome 6p21. Human Molecular Genetics. 9: 1291-301. PMID 10814711 DOI: 10.1093/Hmg/9.9.1291 |
0.448 |
|
| 2000 |
Lyons PA, Armitage N, Argentina F, Denny P, Hill NJ, Lord CJ, Wilusz MB, Peterson LB, Wicker LS, Todd JA. Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping. Genome Research. 10: 446-53. PMID 10779485 DOI: 10.1101/Gr.10.4.446 |
0.441 |
|
| 2000 |
Dudbridge F, Koeleman BPC, Todd JA, Clayton DG. Unbiased application of the transmission/disequilibrium test to multilocus haplotypes. American Journal of Human Genetics. 66: 2009-2012. PMID 10775523 DOI: 10.1086/302915 |
0.344 |
|
| 2000 |
Mein CA, Barratt BJ, Dunn MG, Siegmund T, Smith AN, Esposito L, Nutland S, Stevens HE, Wilson AJ, Phillips MS, Jarvis N, Law S, de Arruda M, Todd JA. Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation. Genome Research. 10: 330-43. PMID 10720574 DOI: 10.1101/Gr.10.3.330 |
0.35 |
|
| 2000 |
Zavattari P, Esposito L, Nutland SL, Todd JA, Cucca F. Transmission-Ratio Distortion at Xp11.4-p21.1 in Type 1 Diabetes American Journal of Human Genetics. 66: 330-332. PMID 10631163 DOI: 10.1086/302701 |
0.428 |
|
| 2000 |
Koeleman BPC, Herr MH, Zavattari P, Dudbridge F, March RE, Campbell DKG, Barnett AH, Bain SC, Mulargia A, Loddo M, Amos WB, Cucca F, Todd JA. Conditional ETDT analysis of the human leukocyte antigen region in type 1 diabetes. Annals of Human Genetics. 64: 215-221. DOI: 10.1046/J.1469-1809.2000.6430215.X |
0.462 |
|
| 2000 |
Koeleman BPC, Dudbridge F, Cordell HJ, Todd JA. Adaptation of the extended transmission/disequilibrium test to distinguish disease associations of multiple loci: the Conditional Extended Transmission/Disequilibrium Test. Annals of Human Genetics. 64: 207-213. DOI: 10.1046/J.1469-1809.2000.6430207.X |
0.405 |
|
| 1999 |
Melander A, Olsson J, Lindberg G, Salzman A, Howard T, Stang P, Lydick E, Emslie-Smith A, Boyle DI, Evans JM, Macdonald TM, Bain J, Sullivan F, Juhl C, ... Todd JA, et al. 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999. Diabetologia. 42: A1-A330. PMID 27770183 DOI: 10.1007/Bf03375458 |
0.403 |
|
| 1999 |
Ahmed S, Bennett ST, Huxtable SJ, Todd JA, Matthews DR, Gough SCL. INS VNTR allelic variation and dynamic insulin secretion in healthy adult non-diabetic Caucasian subjects. Diabetic Medicine. 16: 910-917. PMID 10588520 DOI: 10.1046/J.1464-5491.1999.00169.X |
0.399 |
|
| 1999 |
Todd JA. Interpretation of results from genetic studies of multifactorial diseases Lancet. 354. PMID 10437850 DOI: 10.1016/S0140-6736(99)90243-X |
0.43 |
|
| 1999 |
Todd JA. From genome to aetiology in a multifactorial disease, type 1 diabetes Bioessays. 21: 164-174. PMID 10193189 DOI: 10.1002/(Sici)1521-1878(199902)21:2<164::Aid-Bies10>3.0.Co;2-4 |
0.492 |
|
| 1999 |
Ong KKL, Phillips DI, Fall C, Poulton J, Bennett ST, Golding J, Todd JA, Dunger DB. The insulin gene VNTR, type 2 diabetes and birth weight Nature Genetics. 21: 262-263. PMID 10080175 DOI: 10.1038/6775 |
0.381 |
|
| 1999 |
Lie BA, Todd JA, Pociot F, Nerup J, Akselsen HE, Joner G, Dahl-Jørgensen K, Rønningen KS, Thorsby E, Undlien DE. The predisposition to type 1 diabetes linked to the human leukocyte antigen complex includes at least one non-class II gene American Journal of Human Genetics. 64: 793-800. PMID 10053014 DOI: 10.1086/302283 |
0.473 |
|
| 1999 |
Todd JA. From genomics to aetiology in the multifactorial disease type-1 diabetes Biochemical Society Transactions. 27. DOI: 10.1042/Bst027A001 |
0.429 |
|
| 1998 |
Esposito L, Hill NJ, Pritchard LE, Cucca F, Muxworthy C, Merriman ME, Wilson A, Julier C, Delepine M, Tuomilehto J, Tuomilehto-Wolf E, Ionesco-Tirgoviste C, Nistico L, Buzzetti R, Pozzilli P, ... Todd JA, et al. Genetic analysis of chromosome 2 in type 1 diabetes: Analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster Diabetes. 47: 1797-1799. PMID 9792551 DOI: 10.2337/Diabetes.47.11.1797 |
0.455 |
|
| 1998 |
Cucca F, Esposito L, Goy JV, Merriman ME, Wilson AJ, Reed PW, Bain SC, Todd JA. Investigation of linkage of chromosome 8 to type 1 diabetes: multipoint analysis and exclusion mapping of human chromosome 8 in 593 affected sib-pair families from the U.K. and U.S. Diabetes. 47: 1525-7. PMID 9726245 DOI: 10.2337/Diabetes.47.9.1525 |
0.418 |
|
| 1998 |
Hey PJ, Twells RCJ, Phillips MS, Nakagawa Y, Brown SD, Kawaguchi Y, Cox R, Xie G, Dugan V, Hammond H, Metzker ML, Todd JA, Hess JF. Cloning of a novel member of the low-density lipoprotein receptor family Gene. 216: 103-111. PMID 9714764 DOI: 10.1016/S0378-1119(98)00311-4 |
0.35 |
|
| 1998 |
Vafiadis P, Bennett ST, Todd JA, Grabs R, Polychronakos C. Divergence between genetic determinants of IGF2 transcription levels in leukocytes and of IDDM2-encoded susceptibility to type 1 diabetes. The Journal of Clinical Endocrinology and Metabolism. 83: 2933-2939. PMID 9709972 DOI: 10.1210/Jcem.83.8.5048 |
0.427 |
|
| 1998 |
Brown SD, Twells RC, Hey PJ, Cox RD, Levy ER, Soderman AR, Metzker ML, Caskey CT, Todd JA, Hess JF. Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family. Biochemical and Biophysical Research Communications. 248: 879-88. PMID 9704021 DOI: 10.1006/Bbrc.1998.9061 |
0.325 |
|
| 1998 |
Nakagawa Y, Kawaguchi Y, Twells RCJ, Muxworthy C, Hunter KMD, Wilson A, Merriman ME, Cox RD, Merriman T, Cucca F, McKinney PA, Shield JPH, Tuomilehto J, Tuomilehto-Wolf E, Ionesco-Tirgoviste C, ... Todd JA, et al. Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13 American Journal of Human Genetics. 63: 547-556. PMID 9683605 DOI: 10.1086/301974 |
0.437 |
|
| 1998 |
Cucca F, Goy JV, Kawaguchi Y, Esposito L, Merriman ME, Wilson AJ, Cordell HJ, Bain SC, Todd JA. A male-female bias in type 1 diabetes and linkage to chromosome Xp in MHC HLA-DR3-positive patients. Nature Genetics. 19: 301-2. PMID 9662410 DOI: 10.1038/995 |
0.402 |
|
| 1998 |
Mein CA, Esposito L, Dunn MG, Johnson GC, Timms AE, Goy JV, Smith AN, Sebag-Montefiore L, Merriman ME, Wilson AJ, Pritchard LE, Cucca F, Barnett AH, Bain SC, Todd JA. A search for type 1 diabetes susceptibility genes in families from the United Kingdom. Nature Genetics. 19: 297-300. PMID 9662409 DOI: 10.1038/991 |
0.486 |
|
| 1998 |
Dunger DB, Ong KKL, Huxtable SJ, Sherriff A, Woods KA, Ahmed ML, Golding J, Pembrey ME, Ring S, Bennett ST, Todd JA. Association of the INS VNTR with size at birth Nature Genetics. 19: 98-100. PMID 9590300 DOI: 10.1038/Ng0598-98 |
0.372 |
|
| 1998 |
Podolin PL, Denny P, Armitage N, Lord CJ, Hill NJ, Levy ER, Peterson LB, Todd JA, Wicker LS, Lyons PA. Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse chromosome 3. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 9: 283-6. PMID 9530623 DOI: 10.1007/S003359900749 |
0.449 |
|
| 1998 |
Chowdhury TA, Dyer PH, Kumar S, Gibson SP, Rowe BR, Davies SJ, Marshall SM, Morris PJ, Gill GV, Feeney S, Maxwell P, Savage D, Boulton AJ, Todd JA, Dunger D, et al. Association of apolipoprotein epsilon2 allele with diabetic nephropathy in Caucasian subjects with IDDM. Diabetes. 47: 278-80. PMID 9519726 DOI: 10.2337/Diab.47.2.278 |
0.431 |
|
| 1998 |
Merriman TR, Eaves IA, Twells RCJ, Merriman ME, Danoy PAC, Muxworthy CE, Hunter KMD, Cox RD, Cucca F, McKinney PA, Shield JPH, Baum JD, Tuomilehto J, Tuomilehto-Wolf E, Ionesco-Tirgoviste C, ... Todd JA, et al. Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6) Human Molecular Genetics. 7: 517-524. PMID 9467012 DOI: 10.1093/Hmg/7.3.517 |
0.463 |
|
| 1997 |
Bennett ST, Wilson AJ, Esposito L, Bouzekri N, Undlien DE, Cucca F, Nisticò L, Buzzetti R, Bosi E, Pociot F, Nerup J, Cambon-Thomsen A, Pugliese A, Shield JP, McKinney PA, ... Todd JA, et al. Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group. Nature Genetics. 17: 350-2. PMID 9354805 DOI: 10.1038/Ng1197-350 |
0.484 |
|
| 1997 |
Olivès B, Merriman M, Bailly P, Bain S, Barnett A, Todd J, Cartron JP, Merriman T. The molecular basis of the Kidd blood group polymorphism and its lack of association with type 1 diabetes susceptibility Human Molecular Genetics. 6: 1017-1020. PMID 9215669 DOI: 10.1093/Hmg/6.7.1017 |
0.452 |
|
| 1997 |
Reed PW, Cucca F, Jenkins SC, Merriman ME, Wilson AJ, McKinney PA, Bosi E, Joner G, Ronningen KS, Thorsby E, Undlien DE, Merriman TR, Barnett AH, Bain SC, Todd JA. Evidence for a Type 1 Diabetes Susceptibility Locus (IDDM10) on Human Chromosome 10p11–q11 Human Molecular Genetics. 6: 1011-1016. PMID 9215668 DOI: 10.1093/Hmg/6.7.1011 |
0.419 |
|
| 1997 |
Merriman T, Twells R, Merriman M, Eaves I, Cox R, Cucca F, McKinney P, Shield J, Baum D, Bosi E, Pozzilli P, Nisticò L, Buzzetti R, Joner G, Rønningen KS, ... Todd J, et al. Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21. Human Molecular Genetics. 6: 1003-10. PMID 9215667 DOI: 10.1093/Hmg/6.7.1003 |
0.459 |
|
| 1997 |
Paul T, Shefta J, Gilbey S, Todd JA, Lancaster F, Boylston AW. Individuals from multiplex insulin dependent diabetes mellitus families express higher levels of TCRBV2S1 than controls. Biochemical Society Transactions. 25. PMID 9191358 DOI: 10.1042/Bst025314S |
0.371 |
|
| 1997 |
Waterworth DM, Bennett ST, Gharani N, McCarthy MI, Hague S, Batty S, Conway GS, White D, Todd JA, Franks S, Williamson R. Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome The Lancet. 349: 986-990. PMID 9100625 DOI: 10.1016/S0140-6736(96)08368-7 |
0.426 |
|
| 1997 |
Denny P, Lord CJ, Hill NJ, Goy JV, Levy ER, Podolin PL, Peterson LB, Wicker LS, Todd JA, Lyons PA. Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene. Diabetes. 46: 695-700. PMID 9075813 DOI: 10.2337/Diab.46.4.695 |
0.34 |
|
| 1997 |
Courseaux A, Szepetowski P, Fernandes M, Serizet C, Kawaguchi Y, Grosgeorge J, Perucca-Lostanlen D, Shows TB, Todd JA, Nowak NJ, Gaudray P. Framework YAC contig anchored into a 3.2-Mb high-resolution physical map in proximal 11q13. Genomics. 40: 13-23. PMID 9070914 DOI: 10.1006/Geno.1996.4527 |
0.351 |
|
| 1997 |
Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, Goodyer CG, Wickramasinghe S, Colle E, Polychronakos C. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nature Genetics. 15: 289-92. PMID 9054944 DOI: 10.1038/Ng0397-289 |
0.416 |
|
| 1996 |
Davies JL, Cucca F, Goy JV, Atta ZAA, Merriman ME, Wilson A, Barnett AH, Bain SC, Todd JA. Linkage of Chromosome 6 and Type 1 Diabetes Dna Sequence. 7: 25-26. PMID 9063632 DOI: 10.3109/10425179609015641 |
0.419 |
|
| 1996 |
Chowdhury TA, Dronsfield MJ, Kumar S, Gough SL, Gibson SP, Khatoon A, MacDonald F, Rowe BR, Dunger DB, Dean JD, Davies SJ, Webber J, Smith PR, Mackin P, Marshall SM, ... Todd JA, et al. Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM. Diabetologia. 39: 1108-14. PMID 8877296 DOI: 10.1007/Bf00400661 |
0.46 |
|
| 1996 |
Todd JA, Farrall M. Panning for gold: Genome-wide scanning for linkage in type 1 diabetes Human Molecular Genetics. 5: 1443-1448. PMID 8875250 DOI: 10.1093/Hmg/5.Supplement_1.1443 |
0.472 |
|
| 1996 |
Nisticò L, Buzzetti R, Pritchard LE, Van der Auwera B, Giovannini C, Bosi E, Larrad MT, Rios MS, Chow CC, Cockram CS, Jacobs K, Mijovic C, Bain SC, Barnett AH, Vandewalle CL, ... Todd JA, et al. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry. Human Molecular Genetics. 5: 1075-80. PMID 8817351 DOI: 10.1093/Hmg/5.7.1075 |
0.483 |
|
| 1996 |
Davies JL, Cucca F, Goy JV, Atta ZAA, Merriman ME, Wilson AJ, Barnett AH, Bain SC, Todd JA. Saturation Multipoint Linkage Mapping of Chromosome 6q in Type 1 Diabetes Human Molecular Genetics. 5: 1071-1074. PMID 8817350 DOI: 10.1093/Hmg/5.7.1071 |
0.381 |
|
| 1996 |
Bennett ST, Wilson AJ, Cucca F, Nerup J, Pociot F, McKinney PA, Barnett AH, Bain SC, Todd JA. IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus. Journal of Autoimmunity. 9: 415-421. PMID 8816980 DOI: 10.1006/Jaut.1996.0057 |
0.45 |
|
| 1996 |
Vyse TJ, Todd JA. Genetic analysis of autoimmune disease Cell. 85: 311-318. PMID 8616887 DOI: 10.1016/S0092-8674(00)81110-1 |
0.354 |
|
| 1995 |
Merriman TR, Todd JA. Genetics of autoimmune disease Current Opinion in Immunology. 7: 786-792. PMID 8679121 DOI: 10.1016/0952-7915(95)80049-2 |
0.355 |
|
| 1995 |
Cordell HJ, Kawaguchi Y, Todd JA, Farrall M. An extension of the Maximum Lod Score method to X-linked loci. Annals of Human Genetics. 59: 435-449. PMID 8579335 DOI: 10.1111/J.1469-1809.1995.Tb00761.X |
0.345 |
|
| 1995 |
Lord CJ, Bohlander SK, Hopes EA, Montague CT, Hill NJ, Prins JB, Renjilian RJ, Peterson LB, Wicker LS, Todd JA. Mapping the diabetes polygene Idd3 on mouse chromosome 3 by use of novel congenic strains. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 6: 563-70. PMID 8535060 DOI: 10.1007/Bf00352359 |
0.384 |
|
| 1995 |
Cordell HJ, Todd JA. Multifactorial inheritance in type 1 diabetes Trends in Genetics. 11: 499-504. PMID 8533167 DOI: 10.1016/S0168-9525(00)89160-X |
0.49 |
|
| 1995 |
Undlien DE, Bennett ST, Todd JA, Akselsen HE, Ikäheimo I, Reijonen H, Knip M, Thorsby E, Rønningen KS. Insulin Gene Region-Encoded Susceptibility to IDDM Maps Upstream of the Insulin Gene Diabetes. 44: 620-625. PMID 7789624 DOI: 10.2337/Diab.44.6.620 |
0.407 |
|
| 1995 |
Wardell BB, Michael SD, Tung KS, Todd JA, Blankenhorn EP, McEntee K, Sudweeks JD, Hansen WK, Meeker ND, Griffith JS. Aod1, the immunoregulatory locus controlling abrogation of tolerance in neonatal thymectomy-induced autoimmune ovarian dysgenesis, maps to mouse chromosome 16. Proceedings of the National Academy of Sciences of the United States of America. 92: 4758-62. PMID 7761397 DOI: 10.1073/Pnas.92.11.4758 |
0.345 |
|
| 1995 |
Pritchard LE, Kawaguchi Y, Reed PW, Copeman JB, Davies JL, Barnett AH, Bain SC, Todd JA. Analysis of the CD3 gene region and type 1 diabetes: application of fluorescence-based technology to linkage disequilibrium mapping Human Molecular Genetics. 4: 197-202. PMID 7757067 DOI: 10.1093/Hmg/4.2.197 |
0.456 |
|
| 1995 |
Todd JA, Bennett ST. Diabetes genes - Mutatis mutandis [15] Nature. 374: 601-602. PMID 7715700 DOI: 10.1038/374601B0 |
0.418 |
|
| 1995 |
Copeman JB, Cucca F, Hearne CM, Cornall RJ, Reed PW, Ronningen KS, Undlien DE, Nisticò L, Buzzetti R, Tosi R, Pociot F, Nerup J, Cornélis F, Barnett AH, Bain SC, Todd JA, et al. Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33. Nature Genetics. 9: 80-85. PMID 7704030 DOI: 10.1038/Ng0195-80 |
0.459 |
|
| 1995 |
Wicker LS, Todd JA, Peterson LB. Genetic control of autoimmune diabetes in the NOD mouse. Annual Review of Immunology. 13: 179-200. PMID 7612220 DOI: 10.1146/Annurev.Iy.13.040195.001143 |
0.482 |
|
| 1995 |
Aitman TJ, Todd JA. Molecular genetics of diabetes mellitus Bailliere's Clinical Endocrinology and Metabolism. 9: 631-656. PMID 7575335 DOI: 10.1016/S0950-351X(95)80655-5 |
0.489 |
|
| 1995 |
Todd JA. Genetic analysis of type 1 diabetes using whole genome approaches Proceedings of the National Academy of Sciences of the United States of America. 92: 8560-8565. PMID 7567975 DOI: 10.1073/Pnas.92.19.8560 |
0.499 |
|
| 1994 |
Wicker LS, Leiter EH, Todd JA, Renjilian RJ, Peterson E, Fischer PA, Podolin PL, Zijlstra M, Jaenisch R, Peterson LB. Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes. Diabetes. 43: 500-4. PMID 8314024 DOI: 10.2337/Diab.43.3.500 |
0.374 |
|
| 1994 |
Rodrigues NR, Cornall RJ, Chandler P, Simpson E, Wicker LS, Peterson LB, Todd JA. Mapping of an insulin-dependent diabetes locus, Idd9, in NOD mice to chromosome 4. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 5: 167-70. PMID 8199406 DOI: 10.1007/Bf00352349 |
0.374 |
|
| 1994 |
Wicker LS, Todd JA, Prins JB, Podolin PL, Renjilian RJ, Peterson LB. Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes. The Journal of Experimental Medicine. 180: 1705-13. PMID 7964456 DOI: 10.1084/Jem.180.5.1705 |
0.448 |
|
| 1994 |
Bain SC, Rowe BR, Barnett AH, Todd JA. Parental origin of diabetes-associated HLA types in sibling pairs with type I diabetes. Diabetes. 43: 1462-8. PMID 7958500 DOI: 10.2337/Diab.43.12.1462 |
0.463 |
|
| 1994 |
Powell EE, Wicker LS, Peterson LB, Todd JA. Allelic variation of the type 2 tumor necrosis factor receptor gene. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 5: 726-7. PMID 7873884 DOI: 10.1007/Bf00426081 |
0.305 |
|
| 1994 |
Breen M, Deakln L, Macdonald B, Miller S, Sibson R, Tarttelln E, Avner P, Bourgade F, Guenet J, Montagutelli X, Polrier C, Simon D, Tailor D, Bishop M, Kelly M, et al. Towards high resolution maps of the mouse and human genomes—a facility for ordering markers to 0.1 cM resolution Human Molecular Genetics. 3: 621-627. DOI: 10.1093/Hmg/3.4.621 |
0.301 |
|
| 1993 |
Bain SC, Todd JA. Mapping MHC Class II Genes and Disease-Susceptibility Methods of Molecular Biology. 15: 95-112. PMID 21400268 DOI: 10.1385/0-89603-244-2:95 |
0.357 |
|
| 1993 |
Sudweeks JD, Todd JA, Blankenhorn EP, Wardell BB, Woodward SR, Meeker ND, Estes SS, Teuscher C. Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6. Proceedings of the National Academy of Sciences of the United States of America. 90: 3700-4. PMID 8475118 DOI: 10.1073/Pnas.90.8.3700 |
0.385 |
|
| 1993 |
Todd JA, Reed PW, Prins JB, Bain SC, Palmer SM, Cordell HJ, Pritchard LE, Ghosh S, Cornall RJ, Aitman TJ. Dissection of the pathophysiology of type 1 diabetes by genetic analysis. Autoimmunity. 15: 16-17. PMID 8218844 DOI: 10.3109/08916939309008854 |
0.434 |
|
| 1992 |
Hearne CM, Ghosh S, Todd JA. Microsatellites for linkage analysis of genetic traits Trends in Genetics. 8: 288-294. PMID 1509520 DOI: 10.1016/0168-9525(92)90256-4 |
0.361 |
|
| 1992 |
Todd JA, Bain SC. A practical approach to identification of susceptibility genes for IDDM Diabetes. 41: 1029-1034. PMID 1499854 DOI: 10.2337/Diab.41.9.1029 |
0.398 |
|
| 1992 |
Todd JA. Genetic analysis of susceptibility to Type 1 diabetes Springer Seminars in Immunopathology. 14: 33-58. PMID 1440197 DOI: 10.1007/Bf00197131 |
0.497 |
|
| 1992 |
Bain SC, Barnett AH, Todd JA. Lack of association between type 1 diabetes and the glucokinase gene The Lancet. 340: 54-55. PMID 1351630 DOI: 10.1016/0140-6736(92)92469-V |
0.453 |
|
| 1991 |
Hearne CM, Todd JA. Tetranucleotide repeat polymorphism at the HPRT locus Nucleic Acids Research. 19: 5450. PMID 1923840 DOI: 10.1093/Nar/19.19.5450 |
0.342 |
|
| 1991 |
Cornall RJ, Aitman TJ, Hearne CM, Todd JA. The generation of a library of PCR-analyzed microsatellite variants for genetic mapping of the mouse genome. Genomics. 10: 874-881. PMID 1916820 DOI: 10.1016/0888-7543(91)90175-E |
0.312 |
|
| 1991 |
Mijovic CH, Barnett AH, Todd JA. 7 Trans-racial gene mapping studies BaillièRe's Clinical Endocrinology and Metabolism. 5: 321-340. PMID 1892469 DOI: 10.1016/S0950-351X(05)80130-2 |
0.419 |
|
| 1991 |
Todd JA. A protective role of the environment in the development of Type 1 diabetes? Diabetic Medicine. 8: 906-910. PMID 1838040 DOI: 10.1111/J.1464-5491.1991.Tb01528.X |
0.401 |
|
| 1991 |
Cornall RJ, Prins JB, Todd JA, Pressey A, DeLarato NH, Wicker LS, Peterson LB. Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1. Nature. 353: 262-5. PMID 1832743 DOI: 10.1038/353262A0 |
0.479 |
|
| 1991 |
Hearne CM, McAleer MA, Love JM, Aitman TJ, Cornall RJ, Ghosh S, Knight AM, Prins JB, Todd JA. Additional microsatellite markers for mouse genome mapping. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 1: 273-82. PMID 1794058 DOI: 10.1007/Bf00352339 |
0.325 |
|
| 1991 |
Todd JA, Aitman TJ, Cornall RJ, Ghosh S, Hall J, Hearne CM, Knight A, Love J, McAleer MA, Prins JB. Genetic analysis of a complex, multifactorial disease, autoimmune type 1 (insulin-dependent) diabetes. Research in Immunology. 142: 483. PMID 1754722 DOI: 10.1016/0923-2494(91)90051-J |
0.424 |
|
| 1991 |
Kendall E, Todd JA, Campbell RD. Molecular analysis of the MHC class II region in DR4, DR7, and DR9 haplotypes Immunogenetics. 34: 349-357. PMID 1684173 DOI: 10.1007/Bf01787484 |
0.335 |
|
| 1991 |
Todd JA, Aitman TJ, Cornall RJ, Ghosh S, Hall JR, Hearne CM, Knight AM, Love JM, McAleer MA, Prins JB. Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature. 351: 542-7. PMID 1675432 DOI: 10.1038/351542A0 |
0.439 |
|
| 1990 |
Todd JA, Fukui Y, Kitagawa T, Sasazuki T. The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese. Proceedings of the National Academy of Sciences of the United States of America. 87: 1094-1098. PMID 2300572 DOI: 10.1073/Pnas.87.3.1094 |
0.451 |
|
| 1990 |
Todd JA. Genetic control of autoimmunity in type 1 diabetes Immunology Today. 11: 122-129. PMID 2187469 DOI: 10.1016/0167-5699(90)90049-F |
0.46 |
|
| 1990 |
Todd JA, Mijovic C, Fletcher J, Jenkins D, Bradwell AR, Barnett AH. Trans-racial gene mapping identifies two MHC genes as susceptibility loci for insulin-dependent diabetes mellitus Journal of Autoimmunity. 3: 99. DOI: 10.1016/0896-8411(90)90117-B |
0.43 |
|
| 1989 |
Roberts AN, Leighton B, Todd JA, Cockburn D, Schofield PN, Sutton R, Holt S, Boyd Y, Day AJ, Foot EA, Willis AC, Reid KBM, Cooper GJS. Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus Proceedings of the National Academy of Sciences of the United States of America. 86: 9662-9666. PMID 2690069 DOI: 10.1073/Pnas.86.24.9662 |
0.376 |
|
| 1989 |
Bell JI, Todd JA, McDevitt HO. The molecular basis of HLA-disease association. Advances in Human Genetics. 18: 1-41. PMID 2499168 DOI: 10.1007/978-1-4613-0785-3_1 |
0.382 |
|
| 1989 |
Todd JA, Mijovic C, Fletcher J, Jenkins D, Bradwell AR, Barnett AH. Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping. Nature. 338: 587-9. PMID 2494458 DOI: 10.1038/338587A0 |
0.457 |
|
| 1988 |
Todd JA, Bell JI, McDEVITT HO. HLA antigens and insulin-dependent diabetes Nature. 333: 710-710. PMID 3386713 DOI: 10.1038/333710A0 |
0.382 |
|
| 1988 |
Morel PA, Dorman JS, Todd JA, McDevitt HO, Trucco M. Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study. Proceedings of the National Academy of Sciences of the United States of America. 85: 8111-5. PMID 3186714 DOI: 10.1073/Pnas.85.21.8111 |
0.417 |
|
| 1988 |
Sinha AA, Brautbar C, Szafer F, Friedmann A, Tzfoni E, Todd JA, Steinman L, McDevitt HO. A newly characterized HLA DQ beta allele associated with pemphigus vulgaris. Science (New York, N.Y.). 239: 1026-9. PMID 2894075 DOI: 10.1126/Science.2894075 |
0.398 |
|
| 1988 |
Morel P, Dorman J, Todd J, McDevitt H, Trucco M. Aspartic acid at position 57 of the DQ beta chain protects against type 1 diabetes: A family study Human Immunology. 23: 126. DOI: 10.1016/0198-8859(88)90214-5 |
0.347 |
|
| 1987 |
Bell JI, Denney D, Foster L, Belt T, Todd JA, McDevitt HO. Allelic variation in the DR subregion of the human major histocompatibility complex. Proceedings of the National Academy of Sciences of the United States of America. 84: 6234-8. PMID 3476943 DOI: 10.1073/Pnas.84.17.6234 |
0.373 |
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