Trevor Pugh - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 

121 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Hendrikse LD, Haldipur P, Saulnier O, Millman J, Sjoboen AH, Erickson AW, Ong W, Gordon V, Coudière-Morrison L, Mercier AL, Shokouhian M, Suárez RA, Ly M, Borlase S, Scott DS, ... ... Pugh TJ, et al. Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature. PMID 36131014 DOI: 10.1038/s41586-022-05215-w  0.44
2022 Hamed AA, Kunz DJ, El-Hamamy I, Trinh QM, Subedar OD, Richards LM, Foltz W, Bullivant G, Ware M, Vladoiu MC, Zhang J, Raj AM, Pugh TJ, Taylor MD, Teichmann SA, et al. A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours. Nature Communications. 13: 4178. PMID 35853870 DOI: 10.1038/s41467-022-31408-y  0.664
2022 Boukhaled GM, Gadalla R, Elsaesser HJ, Abd-Rabbo D, Quevedo R, Yang SYC, Guo M, Wang BX, Noamani B, Gray D, Lau SCM, Taylor K, Aung K, Spreafico A, Hansen AR, ... ... Pugh TJ, et al. Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy. Nature Immunology. PMID 35835962 DOI: 10.1038/s41590-022-01262-7  0.751
2022 Hezaveh K, Shinde RS, Klötgen A, Halaby MJ, Lamorte S, Ciudad MT, Quevedo R, Neufeld L, Liu ZQ, Jin R, Grünwald BT, Foerster EG, Chaharlangi D, Guo M, Makhijani P, ... ... Pugh TJ, et al. Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity. Immunity. 55: 324-340.e8. PMID 35139353 DOI: 10.1016/j.immuni.2022.01.006  0.745
2022 Das A, Sudhaman S, Morgenstern D, Coblentz A, Chung J, Stone SC, Alsafwani N, Liu ZA, Karsaneh OAA, Soleimani S, Ladany H, Chen D, Zatzman M, Cabric V, Nobre L, ... ... Pugh TJ, et al. Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency. Nature Medicine. PMID 34992263 DOI: 10.1038/s41591-021-01581-6  0.307
2021 Richards LM, Whitley OKN, MacLeod G, Cavalli FMG, Coutinho FJ, Jaramillo JE, Svergun N, Riverin M, Croucher DC, Kushida M, Yu K, Guilhamon P, Rastegar N, Ahmadi M, Bhatti JK, ... ... Pugh TJ, et al. Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity. Nature Cancer. 2: 157-173. PMID 35122077 DOI: 10.1038/s43018-020-00154-9  0.774
2021 Croucher DC, Richards LM, Tsofack SP, Waller D, Li Z, Wei EN, Huang XF, Chesi M, Bergsagel PL, Sebag M, Pugh TJ, Trudel S. Longitudinal single-cell analysis of a myeloma mouse model identifies subclonal molecular programs associated with progression. Nature Communications. 12: 6322. PMID 34732728 DOI: 10.1038/s41467-021-26598-w  0.76
2021 El Ghamrasni S, Quevedo R, Hawley J, Mazrooei P, Hanna Y, Cirlan I, Zhu H, Bruce JP, Oldfield LE, Yang SYC, Guilhamon P, Reimand J, Cescon DW, Done SJ, Lupien M, ... Pugh TJ, et al. Mutations in Noncoding -Regulatory Elements Reveal Cancer Driver Cistromes in Luminal Breast Cancer. Molecular Cancer Research : McR. PMID 34556523 DOI: 10.1158/1541-7786.MCR-21-0471  0.767
2021 Cindy Yang SY, Lien SC, Wang BX, Clouthier DL, Hanna Y, Cirlan I, Zhu K, Bruce JP, El Ghamrasni S, Iafolla MAJ, Oliva M, Hansen AR, Spreafico A, Bedard PL, Lheureux S, ... ... Pugh TJ, et al. Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity. Nature Communications. 12: 5137. PMID 34446728 DOI: 10.1038/s41467-021-25432-7  0.322
2021 Pryszlak M, Wiggans M, Chen X, Jaramillo JE, Burns SE, Richards LM, Pugh TJ, Kaplan DR, Huang X, Dirks PB, Pearson BJ. The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells. Cell Reports. 34: 108903. PMID 33789112 DOI: 10.1016/j.celrep.2021.108903  0.665
2021 Sachamitr P, Ho JC, Ciamponi FE, Ba-Alawi W, Coutinho FJ, Guilhamon P, Kushida MM, Cavalli FMG, Lee L, Rastegar N, Vu V, Sánchez-Osuna M, Coulombe-Huntington J, Kanshin E, Whetstone H, ... ... Pugh TJ, et al. PRMT5 inhibition disrupts splicing and stemness in glioblastoma. Nature Communications. 12: 979. PMID 33579912 DOI: 10.1038/s41467-021-21204-5  0.688
2021 Uppaluri R, Campbell KM, Egloff AM, Zolkind P, Skidmore ZL, Nussenbaum B, Paniello RC, Rich JT, Jackson R, Pipkorn P, Michel LS, Ley J, Oppelt P, Dunn GP, Barnell EK, ... ... Pugh TJ, et al. Correction: Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-unrelated Head and Neck Cancer: A Multicenter, Phase II Trial. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 27: 357. PMID 33397681 DOI: 10.1158/1078-0432.CCR-20-4484  0.474
2021 Richards LM, Whitley OKN, MacLeod G, Cavalli FMG, Coutinho FJ, Jaramillo JE, Svergun N, Riverin M, Croucher DC, Kushida M, Yu K, Guilhamon P, Rastegar N, Ahmadi M, Bhatti JK, ... ... Pugh TJ, et al. Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity Nature Cancer. 2: 157-173. DOI: 10.1038/s43018-020-00154-9  0.341
2020 Oldfield LE, Li T, Tone A, Aronson M, Edwards M, Holter S, Quevedo R, Van de Laar E, Lerner-Ellis J, Pollett A, Clarke B, Tabori U, Gallinger S, Ferguson SE, Pugh TJ. An integrative DNA sequencing and methylation panel to assess mismatch repair deficiency. The Journal of Molecular Diagnostics : Jmd. PMID 33259954 DOI: 10.1016/j.jmoldx.2020.11.006  0.758
2020 Restall IJ, Cseh O, Richards LM, Pugh TJ, Luchman HA, Weiss S. Brain tumor stem cell dependence on glutaminase reveals a metabolic vulnerability through the amino acid deprivation response pathway. Cancer Research. PMID 33106333 DOI: 10.1158/0008-5472.CAN-19-3923  0.673
2020 Quevedo R, Smirnov P, Tkachuk D, Ho C, El-Hachem N, Safikhani Z, Pugh TJ, Haibe-Kains B. Assessment of Genetic Drift in Large Pharmacogenomic Studies. Cell Systems. PMID 32937114 DOI: 10.1016/j.cels.2020.08.012  0.758
2020 Manoranjan B, Venugopal C, Bakhshinyan D, Adile AA, Richards L, Kameda-Smith MM, Whitley O, Dvorkin-Gheva A, Subapanditha M, Savage N, Tatari N, McKenna D, Bassey-Archibong B, Winegarden N, Hallett R, ... ... Pugh TJ, et al. Wnt activation as a therapeutic strategy in medulloblastoma. Nature Communications. 11: 4323. PMID 32859895 DOI: 10.1038/S41467-020-17953-4  0.661
2020 Uppaluri R, Campbell KM, Egloff AM, Zolkind P, Skidmore ZL, Nussenbaum B, Paniello RC, Rich JT, Jackson R, Pipkorn P, Michel LS, Ley J, Oppelt P, Dunn GP, Barnell EK, ... ... Pugh TJ, et al. Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase 2 Trial. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32665297 DOI: 10.1158/1078-0432.Ccr-20-1695  0.501
2020 Mohanraj S, Díaz-Mejía JJ, Pham MD, Elrick H, Husić M, Rashid S, Luo P, Bal P, Lu K, Patel S, Mahalanabis A, Naidas A, Christensen E, Croucher D, Richards LM, ... ... Pugh TJ, et al. CReSCENT: CanceR Single Cell ExpressioN Toolkit. Nucleic Acids Research. PMID 32479601 DOI: 10.1093/Nar/Gkaa437  0.759
2020 Quevedo R, Spreafico A, Bruce J, Danesh A, El Ghamrasni S, Giesler A, Hanna Y, Have C, Li T, Yang SYC, Zhang T, Asa SL, Haibe-Kains B, Krzyzanowska M, Smith AC, ... ... Pugh TJ, et al. Centromeric cohesion failure invokes a conserved choreography of chromosomal mis-segregations in pancreatic neuroendocrine tumor. Genome Medicine. 12: 38. PMID 32345369 DOI: 10.1186/S13073-020-00730-9  0.765
2020 Loganathan SK, Schleicher K, Malik A, Quevedo R, Langille E, Teng K, Oh RH, Rathod B, Tsai R, Samavarchi-Tehrani P, Pugh TJ, Gingras AC, Schramek D. Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling. Science (New York, N.Y.). 367: 1264-1269. PMID 32165588 DOI: 10.1126/Science.Aax0902  0.771
2020 Pimentel Muniz T, Sorotsky H, Kanjanapan Y, Rose AAN, Araujo DV, Fortuna A, Ghazarian DK, Saeed Kamil Z, Pugh TJ, Mah M, Thiagarajah M, Spreafico A, Hogg D. Genomic landscape of malignant peripheral nerve sheath tumor (MPNST)-like melanoma. Journal of Clinical Oncology. 38: e22072-e22072. DOI: 10.1200/jco.2020.38.15_suppl.e22072  0.328
2020 Zhao EY, Torchia J, Fortuna A, Torti D, Yu C, Shah E, McCarthy A, Stockley T, Sabatini P, Bartlett J, Siu LL, Bedard PL, Pugh TJ. Exomes and transcriptomes to reveal actionable findings in patients with negative-targeted panel sequencing. Journal of Clinical Oncology. 38: 3562-3562. DOI: 10.1200/jco.2020.38.15_suppl.3562  0.351
2020 Kim RS, Oldfield LE, Tone A, Pollett A, Van de Laar E, Pedersen S, Wellum J, Clarke B, Pugh TJ, Ferguson S. Comprehensive molecular assessment of mismatch repair deficiency in Lynch-associated ovarian cancers using next-generation sequencing (NGS) panel. Journal of Clinical Oncology. 38: 1523-1523. DOI: 10.1200/jco.2020.38.15_suppl.1523  0.318
2020 Malkin D, Light N, Subrasi V, Brew B, Paramathas S, Nabbi A, Prykhozhij S, Pugh T, Berman J, Goldenberg A, Shlien A. Abstract IA02: Novel strategies for early cancer detection and prevention: The Li-Fraumeni syndrome story Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-Ia02  0.44
2019 Colombo I, Garg S, Danesh A, Bruce J, Shaw P, Tan Q, Quevedo R, Braunstein M, Oza AM, Pugh T, Lheureux S. Heterogeneous alteration of the ERBB3-MYC axis associated with MEK inhibitor resistance in a -mutated low-grade serous ovarian cancer patient. Cold Spring Harbor Molecular Case Studies. 5. PMID 31836588 DOI: 10.1101/mcs.a004341  0.788
2019 Tsang CM, Yan Lui VW, Bruce JP, Pugh TJ, Lo KW. Translational Genomics of Nasopharyngeal Cancer. Seminars in Cancer Biology. PMID 31521748 DOI: 10.1016/j.semcancer.2019.09.006  0.312
2019 Johnston M, Nikolic A, Ninkovic N, Guilhamon P, Cavalli F, Seaman S, Zemp F, Lee J, Abdelkareem A, Ellestad K, Murison A, Kushida M, Coutinho F, Ma Y, Mungall A, ... ... Pugh T, et al. High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma. Genome Research. PMID 31249064 DOI: 10.1101/Gr.246520.118  0.448
2019 Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, ... ... Pugh T, et al. Childhood cerebellar tumours mirror conserved fetal transcriptional programs. Nature. PMID 31043743 DOI: 10.1038/S41586-019-1158-7  0.485
2019 Hoffman M, Gillmor A, Kunz DJ, Johnston MJ, Nikolic A, Narta K, Zarrei M, King JC, Ellestad K, Dang NH, Cavalli FMG, Kushida M, Coutinho FJ, Zhu Y, Luu B, ... ... Pugh TJ, et al. Intratumoral genetic and functional heterogeneity in pediatric glioblastoma. Cancer Research. PMID 30877103 DOI: 10.1158/0008-5472.Can-18-3441  0.526
2019 Coffey DG, Landgren O, Xu Y, Kazandjian D, Pugh TJ, Gnjatic S, Warren EH, Green DJ. Reduced Antigen Presentation May Contribute to Immunomodulatory Drug Resistance in Multiple Myeloma Blood. 134: 4367-4367. DOI: 10.1182/blood-2019-126222  0.34
2019 Murphy T, Zou J, Wang TT, Zheng Y, Zhao Z, Shapiro RM, Gupta V, Maze D, McNamara CJ, Minden MD, Schimmer AD, Schuh AC, Sibai H, Yee KW, Stockley TL, ... ... Pugh T, et al. High Interpatient Variability in Molecular MRD Response to Consolidation Chemotherapy in Acute Myeloid Leukemia Blood. 134: 1424-1424. DOI: 10.1182/Blood-2019-122890  0.355
2019 Taylor K, Yau HL, Wang BX, Bedard PL, Razak AR, Hansen AR, Spreafico A, Cescon D, Butler MO, Oza AM, Lheureux S, Stjepanovic N, Wang L, As BV, Boross-Harmer S, ... Pugh T, et al. Abstract CT190: A Phase II basket study of hypomethylating agent oral cc-486 and durvalumab in advanced solid tumors (METADUR) Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Ct190  0.343
2019 Tone AA, Oldfield L, Laar EVd, Li T, Cirlan I, Vicus D, Clarke BA, Pugh T, Ferguson SE. Streamlined next-generation sequencing panel provides comprehensive molecular assessment of mismatch repair deficiency in endometrial and non-serous ovarian cancer Gynecologic Oncology. 154: 79. DOI: 10.1016/J.Ygyno.2019.04.187  0.347
2019 Stewart E, Martins-Filho S, Cabanero M, Wang A, Huang J, Bao H, Wu X, Patel D, Chen Z, Law J, Bradbury P, Shepherd F, Leighl N, Tsao M, Pugh T, et al. P2.14-62 Early, Subclinical SCLC Transformation in Patients with EGFR Mutant Lung Cancer Receiving Osimertinib, Detected Through Cell-Free DNA Journal of Thoracic Oncology. 14. DOI: 10.1016/J.Jtho.2019.08.1847  0.314
2019 Stewart E, Wang A, Huang J, Bao H, Wu X, Patel D, Chen Z, Law J, Bradbury P, Shepherd F, Sacher A, Tsao M, Bratman S, Leighl N, Pugh T, et al. P1.14-07 Genomic Profiling of Liquid Biopsies During 2nd/3rd Generation ALK Inhibitor Therapy to Identify Novel Mechanisms of Resistance Journal of Thoracic Oncology. 14. DOI: 10.1016/J.Jtho.2019.08.1158  0.303
2018 Yang SYC, Lheureux S, Karakasis K, Burnier JV, Bruce JP, Clouthier DL, Danesh A, Quevedo R, Dowar M, Hanna Y, Li T, Lu L, Xu W, Clarke BA, Ohashi PS, ... ... Pugh TJ, et al. Landscape of genomic alterations in high-grade serous ovarian cancer from exceptional long- and short-term survivors. Genome Medicine. 10: 81. PMID 30382883 DOI: 10.1186/S13073-018-0590-X  0.751
2018 Weberpals JI, Pugh T, Goss GD, Lo B, Wright NA, Bernard L, Torti D, Torchia J, Rath P, Leon A, Marsh K, Hodgson DR, Jones GN, Duciaume M, Howat WJ, et al. Tumor molecular profiling to differentiate extreme responses to first-line platinum-based chemotherapy in suboptimally debulked serous ovarian cancer patients. Journal of Clinical Oncology. 36: 5561-5561. DOI: 10.1200/Jco.2018.36.15_Suppl.5561  0.355
2018 Stewart E, Cabanero M, Raghavan V, Bruce J, Guilhamon P, Singhania R, Pham N, Shen SY, Li T, Li M, Leighl N, Shepherd F, Pugh T, Carvalho DD, Lupien M, et al. MA27.03 Multi-Omic Characterization of TKI-Treated Drug-Tolerant Cell Population in an EGFR-Mutated NSCLC Primary-Derived Xenograft Journal of Thoracic Oncology. 13. DOI: 10.1016/J.Jtho.2018.08.549  0.329
2018 Moskovitz M, Cabanero M, Torchia J, Sorotsky H, Weiss J, Pintilie M, Leighl N, Bradbury P, Liu G, Zadeh G, Doherty M, Kia A, Torti D, Tsao M, Pugh T, et al. P3.16-07 The Impact of Clinical and Molecular Profile of Resected EGFR-Mutant Non-Small Cell Lung Cancer on the Risk of Developing Brain Metastases Journal of Thoracic Oncology. 13. DOI: 10.1016/J.Jtho.2018.08.1914  0.322
2018 Sorotsky H, Cabanero M, Moskovitz M, Weiss J, Pintilie M, Leighl N, Bradbury P, Liu G, Kia A, Pugh T, Torti D, Torchia J, Tsao M, Shepherd F. P3.03-29 The Prognostic Effect of Tumor Mutation Burden and Smoking History in Resected EGFR Mutant Non-Small Cell Lung Cancer Journal of Thoracic Oncology. 13. DOI: 10.1016/J.Jtho.2018.08.1706  0.364
2017 Lan X, Jörg DJ, Cavalli FMG, Richards LM, Nguyen LV, Vanner RJ, Guilhamon P, Lee L, Kushida MM, Pellacani D, Park NI, Coutinho FJ, Whetstone H, Selvadurai HJ, Che C, ... ... Pugh TJ, et al. Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy. Nature. PMID 28854171 DOI: 10.1038/Nature23666  0.67
2017 Rheinbay E, Parasuraman P, Grimsby J, Tiao G, Engreitz JM, Kim J, Lawrence MS, Taylor-Weiner A, Rodriguez-Cuevas S, Rosenberg M, Hess J, Stewart C, Maruvka YE, Stojanov P, Cortes ML, ... ... Pugh TJ, et al. Recurrent and functional regulatory mutations in breast cancer. Nature. PMID 28658208 DOI: 10.1038/Nature22992  0.507
2017 Thomas M, Sukhai MA, Zhang T, Dolatshahi R, Harbi D, Garg S, Misyura M, Pugh T, Stockley TL, Kamel-Reid S. Integration of Technical, Bioinformatic, and Variant Assessment Approaches in the Validation of a Targeted Next-Generation Sequencing Panel for Myeloid Malignancies. Archives of Pathology & Laboratory Medicine. 141: 759-775. PMID 28557600 DOI: 10.5858/Arpa.2016-0547-Ra  0.351
2017 Lheureux S, Bruce JP, Burnier JV, Karakasis K, Shaw PA, Clarke BA, Yang SY, Quevedo R, Li T, Dowar M, Bowering V, Pugh TJ, Oza AM. Somatic BRCA1/2 Recovery as a Resistance Mechanism After Exceptional Response to Poly (ADP-ribose) Polymerase Inhibition. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2016713677. PMID 28221868 DOI: 10.1200/Jco.2016.71.3677  0.789
2017 Chmielecki J, Bailey M, He J, Elvin J, Vergilio JA, Ramkissoon S, Suh J, Frampton GM, Sun JX, Morley S, Spritz D, Ali S, Gay L, Erlich RL, Ross JS, ... ... Pugh TJ, et al. Genomic Profiling of a Large Set of Diverse Pediatric Cancers Identifies Known and Novel Mutations across Tumor Spectra. Cancer Research. PMID 28069802 DOI: 10.1158/0008-5472.Can-16-1106  0.345
2017 Gao J, Ciftci E, Raman P, Lukasse P, Bahceci I, Abeshouse A, Chen H, Bruijn Id, Gross B, Heins Z, Kundra R, Lisman A, Ochoa A, Sheridan R, Sumer O, ... ... Pugh T, et al. Abstract 2607: The cBioPortal for Cancer Genomics: an open source platform for accessing and interpreting complex cancer genomics data in the era of precision medicine Cancer Research. 77: 2607-2607. DOI: 10.1158/1538-7445.Am2017-2607  0.392
2017 Ghamrasni SE, Guilhamon P, Quevedo R, Yang C, Lupien M, Pugh T. Abstract 2410: Toward mutation analysis of regulatory elements: Epigenetic profiling of primary breast tumors Cancer Research. 77: 2410-2410. DOI: 10.1158/1538-7445.Am2017-2410  0.44
2017 Stewart E, Cabanero M, Pham N, Shen SY, Li T, Bruce J, Li M, Leighl N, Shepherd F, Pugh T, De Carvalho D, Lupien M, Liu G, Tsao M. P3.02b-028 Characterizing Residual Erlotinib-Tolerant Population Using EGFR-Mutated NSCLC Primary Derived Xenografts: The Last Holdouts Journal of Thoracic Oncology. 12: S1203. DOI: 10.1016/J.Jtho.2016.11.1695  0.302
2017 Kis O, Chow S, Kaedbey R, Danesh A, Dowar M, Li T, Li Z, Liu J, Masih-Khan E, Mulder D, Zhang T, Bratman S, Oza A, Kamel-Reid S, Pugh T, et al. Targeted Sequencing of Circulating Cell-free DNA in Multiple Myeloma Allows Analysis of Somatic Mutations, Copy Number Aberrations, and Translocations Clinical Lymphoma, Myeloma & Leukemia. 17. DOI: 10.1016/J.Clml.2017.03.167  0.392
2017 Pugh T, Fink J, Lu X, Matthew S, Murata-Collins J, Surti U, Willem P, Fang M. Development of Consensus Recommendations for Genomic Testing of Plasma Cell Neoplasms for Diagnosis and Prognosis Cancer Genetics and Cytogenetics. 214: 38. DOI: 10.1016/J.Cancergen.2017.04.020  0.307
2016 Sholl LM, Do K, Shivdasani P, Cerami E, Dubuc AM, Kuo FC, Garcia EP, Jia Y, Davineni P, Abo RP, Pugh TJ, van Hummelen P, Thorner AR, Ducar M, Berger AH, et al. Institutional implementation of clinical tumor profiling on an unselected cancer population. Jci Insight. 1: e87062. PMID 27882345 DOI: 10.1172/Jci.Insight.87062  0.51
2016 Agnihotri S, Jalali S, Wilson MR, Danesh A, Li M, Klironomos G, Krieger JR, Mansouri A, Khan O, Mamatjan Y, Landon-Brace N, Tung T, Dowar M, Li T, Bruce JP, ... ... Pugh TJ, et al. The genomic landscape of schwannoma. Nature Genetics. PMID 27723760 DOI: 10.1038/Ng.3688  0.543
2016 Giannikou K, Malinowska IA, Pugh TJ, Yan R, Tseng YY, Oh C, Kim J, Tyburczy ME, Chekaluk Y, Liu Y, Alesi N, Finlay GA, Wu CL, Signoretti S, Meyerson M, et al. Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development. Plos Genetics. 12: e1006242. PMID 27494029 DOI: 10.1371/Journal.Pgen.1006242  0.501
2016 Morrissy AS, Garzia L, Shih DJ, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli FM, Ramaswamy V, Lindsay PE, Jelveh S, Donovan LK, Wang X, Luu B, Zayne K, ... ... Pugh T, et al. Divergent clonal selection dominates medulloblastoma at recurrence. Nature. PMID 26760213 DOI: 10.1038/Nature16478  0.508
2016 Karamboulas C, Bruce J, Qiu X, Meens J, Pereira K, Hyatt E, Huang SH, Xu W, Pugh T, Ailles L. Abstract B08: Patient-derived xenografts of oral squamous cell carcinoma: A model system for the identification of prognostic molecular signatures and for preclinical assessment of targeted therapies Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-B08  0.409
2016 Lheureux S, Yang C, Shaw P, Clarke B, Tsao J, Karakasis K, Butler M, Salman N, Dowar M, Xu J, Poulain L, Ohashi PS, Pugh T, Oza A. Abstract A35: Elucidating mechanisms involved in long-term response to platinum-based chemotherapy in high-grade serous ovarian cancer. Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Ovca15-A35  0.409
2016 Mahe E, Mulder D, Dowar M, Sukhai M, Nguyen L, Ohashi P, Delabie J, Stockley TL, Pugh T, Kamel-Reid S. Abstract 846: Improving T-cell receptor clonotyping of T-cell lymphomas using hybrid-Capture and next-generation sequencing Cancer Research. 76: 846-846. DOI: 10.1158/1538-7445.Am2016-846  0.332
2016 Gao J, Lindsay J, Watt S, Bahceci I, Lukasse P, Abeshouse A, Chen H, Bruijn Id, Gross B, Li D, Kundra R, Heins Z, Reis-Filho J, Sumer O, Sun Y, ... ... Pugh T, et al. Abstract 5277: The cBioPortal for cancer genomics and its application in precision oncology Cancer Research. 76: 5277-5277. DOI: 10.1158/1538-7445.Am2016-5277  0.372
2016 Agnihotri S, Wilson M, Jalali S, Danesh A, Li M, Klironomos G, Krieger J, Mansouri A, Khan O, Yasin M, Tonge P, Agarwalla PK, Bi WL, Dunn I, Beroukhim R, ... ... Pugh T, et al. GENT-36. THE GENOMIC LANDSCAPE OF SCHWANNOMA Neuro-Oncology. 18: vi81-vi82. DOI: 10.1093/Neuonc/Now212.342  0.503
2015 Cordeddu V, Yin JC, Gunnarsson C, Virtanen C, Drunat S, Lepri F, De Luca A, Rossi C, Ciolfi A, Pugh TJ, Bruselles A, Priest JR, Pennacchio LA, Lu Z, Danesh A, et al. Activating mutations affecting the Dbl homology domain of SOS2 cause Noonan syndrome. Human Mutation. PMID 26173643 DOI: 10.1002/Humu.22834  0.755
2015 Ramos AH, Lichtenstein L, Gupta M, Lawrence MS, Pugh TJ, Saksena G, Meyerson M, Getz G. Oncotator: cancer variant annotation tool. Human Mutation. 36: E2423-9. PMID 25703262 DOI: 10.1002/Humu.22771  0.489
2015 Garg S, Sukhai MA, Thomas M, Mah M, Zhang T, Pugh T, Kamel-Reid S, Stockley TL. Abstract 628: Determinants of quality of next-generation sequencing output from the strand-specific TruSight Tumor Sequencing Panel in a clinical diagnostic setting Cancer Research. 75: 628-628. DOI: 10.1158/1538-7445.Am2015-628  0.369
2015 Kaedbey R, Kis O, Danesh A, Dowar M, Li T, Li Z, Liu J, Mansour M, Sukhai M, Zhang T, Kamel-Reid S, Pugh TJ, Trudel S. Abstract 615: Noninvasive diagnosis of actionable mutations by deep sequencing of circulating tumor DNA in multiple myeloma Cancer Research. 75: 615-615. DOI: 10.1158/1538-7445.Am2015-615  0.331
2015 Schonbach M, Danesh A, Bruce J, Woodburn T, Davidsen T, Hermida L, Gesuwan P, Auvil JG, Hampton O, Wheeler D, Gastier-Foster J, Smith M, Gerhard D, Maris JM, Reynolds P, ... Pugh TJ, et al. Abstract 484: Fidelity of subclonal representation in human neuroblastoma-derived cell line and patient-derived xenograft models: A report from the NCI-TARGET project Cancer Research. 75: 484-484. DOI: 10.1158/1538-7445.Am2015-484  0.315
2015 Thomas M, Sukhai M, Zhang T, Harbi D, Souza JD, MacDonald K, Pugh T, Minden M, Schuh A, Stockley TL, Kamel-Reid S. Abstract 4260: Clinical testing and implementation of the TruSight Myeloid Next Generation Sequencing (NGS) panel for identification of clinically relevant variants in hematological malignancies Cancer Research. 75: 4260-4260. DOI: 10.1158/1538-7445.Am2015-4260  0.412
2015 Mahe ER, Pugh T, Stockley T, Kamel-Reid S. Abstract 3708: Filling the void of Canadian T-cell lymphoma epidemiology: Data from the canadian institute for health information discharge abstract database Cancer Research. 75: 3708-3708. DOI: 10.1158/1538-7445.Am2015-3708  0.303
2014 Mandelker D, Amr SS, Pugh T, Gowrisankar S, Shakhbatyan R, Duffy E, Bowser M, Harrison B, Lafferty K, Mahanta L, Rehm HL, Funke BH. Comprehensive diagnostic testing for stereocilin: an approach for analyzing medically important genes with high homology. The Journal of Molecular Diagnostics : Jmd. 16: 639-47. PMID 25157971 DOI: 10.1016/J.Jmoldx.2014.06.003  0.325
2014 Pugh TJ, Yu W, Yang J, Field AL, Ambrogio L, Carter SL, Cibulskis K, Giannikopoulos P, Kiezun A, Kim J, McKenna A, Nickerson E, Getz G, Hoffher S, Messinger YH, et al. Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA hairpin loop sequences. Oncogene. 33: 5295-302. PMID 24909177 DOI: 10.1038/Onc.2014.150  0.444
2014 Kool M, Jones DT, Jäger N, Northcott PA, Pugh TJ, Hovestadt V, Piro RM, Esparza LA, Markant SL, Remke M, Milde T, Bourdeaut F, Ryzhova M, Sturm D, Pfaff E, et al. Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer Cell. 25: 393-405. PMID 24651015 DOI: 10.1016/J.Ccr.2014.02.004  0.524
2014 Mack SC, Witt H, Piro RM, Gu L, Zuyderduyn S, Stütz AM, Wang X, Gallo M, Garzia L, Zayne K, Zhang X, Ramaswamy V, Jäger N, Jones DT, Sill M, ... Pugh TJ, et al. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Nature. 506: 445-50. PMID 24553142 DOI: 10.1038/Nature13108  0.453
2014 Weinstein JN, Akbani R, Broom BM, Wang W, Verhaak RGW, McConkey D, Lerner S, Morgan M, Creighton CJ, Smith C, Cherniack AD, Kim J, Pedamallu CS, Noble MS, Al-Ahmadie HA, ... ... Pugh T, et al. Comprehensive molecular characterization of urothelial bladder carcinoma Nature. 507: 315-322. PMID 24476821 DOI: 10.1038/Nature12965  0.779
2014 Ojesina AI, Lichtenstein L, Freeman SS, Pedamallu CS, Imaz-Rosshandler I, Pugh TJ, Cherniack AD, Ambrogio L, Cibulskis K, Bertelsen B, Romero-Cordoba S, Treviño V, Vazquez-Santillan K, Guadarrama AS, Wright AA, et al. Landscape of genomic alterations in cervical carcinomas. Nature. 506: 371-5. PMID 24390348 DOI: 10.1038/Nature12881  0.471
2014 Wei JS, Patidar R, Shern J, Zhang S, Pugh T, Diskin SJ, Sindiri S, Song YK, Liao H, Wen X, Wang J, Skapek SX, Anderson JR, Barr FG, Seeger RC, et al. Abstract 5081: Systematic identification of germline mutations in rhabdomyosarcoma and neuroblastoma using massively paralleled sequencing Cancer Research. 74: 5081-5081. DOI: 10.1158/1538-7445.Am2014-5081  0.472
2013 Francis JM, Kiezun A, Ramos AH, Serra S, Pedamallu CS, Qian ZR, Banck MS, Kanwar R, Kulkarni AA, Karpathakis A, Manzo V, Contractor T, Philips J, Nickerson E, Pho N, ... ... Pugh T, et al. Somatic mutation of CDKN1B in small intestine neuroendocrine tumors. Nature Genetics. 45: 1483-6. PMID 24185511 DOI: 10.1038/Ng.2821  0.536
2013 Akbay EA, Koyama S, Carretero J, Altabef A, Tchaicha JH, Christensen CL, Mikse OR, Cherniack AD, Beauchamp EM, Pugh TJ, Wilkerson MD, Fecci PE, Butaney M, Reibel JB, Soucheray M, et al. Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discovery. 3: 1355-63. PMID 24078774 DOI: 10.1158/2159-8290.Cd-13-0310  0.424
2013 Duzkale H, Shen J, Mclaughlin H, Alfares A, Kelly M, Pugh T, Funke B, Rehm H, Lebo M. A systematic approach to assessing the clinical significance of genetic variants Clinical Genetics. 84: 453-463. PMID 24033266 DOI: 10.1111/Cge.12257  0.307
2013 Liao RG, Jung J, Tchaicha J, Wilkerson MD, Sivachenko A, Beauchamp EM, Liu Q, Pugh TJ, Pedamallu CS, Hayes DN, Gray NS, Getz G, Wong KK, Haddad RI, Meyerson M, et al. Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma. Cancer Research. 73: 5195-205. PMID 23786770 DOI: 10.1158/0008-5472.Can-12-3950  0.47
2013 Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A, Carter SL, Stewart C, Mermel CH, Roberts SA, Kiezun A, Hammerman PS, McKenna A, Drier Y, Zou L, ... ... Pugh TJ, et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 499: 214-8. PMID 23770567 DOI: 10.1038/Nature12213  0.698
2013 Pugh TJ, Morozova O, Attiyeh EF, Asgharzadeh S, Wei JS, Auclair D, Carter SL, Cibulskis K, Hanna M, Kiezun A, Kim J, Lawrence MS, Lichenstein L, McKenna A, Pedamallu CS, et al. The genetic landscape of high-risk neuroblastoma. Nature Genetics. 45: 279-84. PMID 23334666 DOI: 10.1038/Ng.2529  0.769
2013 Griffith M, Mwenifumbo JC, Cheung PY, Paul JE, Pugh TJ, Tang MJ, Chittaranjan S, Morin RD, Asano JK, Ally AA, Miao L, Lee A, Chan SY, Taylor G, Severson T, et al. Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer. The Pharmacogenomics Journal. 13: 148-58. PMID 22249354 DOI: 10.1038/Tpj.2011.65  0.741
2013 Sasaki MM, Skol AD, Pugh TJ, Meyerson M, Onel K. Abstract 4018: Whole exome sequencing analysis of familial Medulloblastoma. Cancer Research. 73: 4018-4018. DOI: 10.1158/1538-7445.Am2013-4018  0.515
2013 Pugh TJ, Yu W, Yang J, Ambrogio L, Carter SL, Kiezun A, McKenna A, Giannikopoulos P, Getz G, Messinger Y, Meyerson M, Hill DA. Abstract 3806: Progressive biallelic loss of TP53 is associated with progression of pleuropulmonary blastoma initiated by germline loss and somatic mutation of DICER1. Cancer Research. 73: 3806-3806. DOI: 10.1158/1538-7445.Am2013-3806  0.516
2013 Wood AC, Pugh TJ, Morozova O, Koster J, Molenaar JJ, Pineros V, Bosse KR, Perin JC, Diskin S, Diamond MA, Marra M, Meyerson M, Versteeg R, Maris JM. Abstract 3804: Rare DNA variants are enriched at the BARD1 locus and likely influence neuroblastoma susceptibility. Cancer Research. 73: 3804-3804. DOI: 10.1158/1538-7445.Am2013-3804  0.605
2013 Ambady P, Holdhoff M, Ferrigno C, Grossman S, Anderson MD, Liu D, Conrad C, Penas-Prado M, Gilbert MR, Yung AWK, Groot Jd, Aoki T, Nishikawa R, Sugiyama K, Nonoguchi N, ... ... Pugh T, et al. Neuro/Medical Oncology Neuro-Oncology. 15: 120-120. DOI: 10.1093/Neuonc/Not182  0.422
2012 Imielinski M, Berger AH, Hammerman PS, Hernandez B, Pugh TJ, Hodis E, Cho J, Suh J, Capelletti M, Sivachenko A, Sougnez C, Auclair D, Lawrence MS, Stojanov P, Cibulskis K, et al. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell. 150: 1107-20. PMID 22980975 DOI: 10.1016/J.Cell.2012.08.029  0.484
2012 Jones DT, Jäger N, Kool M, Zichner T, Hutter B, Sultan M, Cho YJ, Pugh TJ, Hovestadt V, Stütz AM, Rausch T, Warnatz HJ, Ryzhova M, Bender S, Sturm D, et al. Dissecting the genomic complexity underlying medulloblastoma. Nature. 488: 100-5. PMID 22832583 DOI: 10.1038/Nature11284  0.515
2012 Pugh TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, Auclair D, Bochicchio J, Carneiro MO, Carter SL, Cibulskis K, Erlich RL, Greulich H, Lawrence MS, Lennon NJ, McKenna A, Meldrim J, et al. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature. 488: 106-10. PMID 22820256 DOI: 10.1038/Nature11329  0.507
2012 Berger MF, Hodis E, Heffernan TP, Deribe YL, Lawrence MS, Protopopov A, Ivanova E, Watson IR, Nickerson E, Ghosh P, Zhang H, Zeid R, Ren X, Cibulskis K, Sivachenko AY, ... ... Pugh TJ, et al. Melanoma genome sequencing reveals frequent PREX2 mutations. Nature. 485: 502-6. PMID 22622578 DOI: 10.1038/Nature11071  0.513
2012 Jäger N, Jones DT, Kool M, Zichner T, Hutter B, Sultan M, Cho Y, Pugh TJ, Hovestadt V, Stütz AM, Rausch T, Warnatz H, Brors B, Northcott PA, Taylor MD, et al. ICGC PedBrain - dissecting the genomic complexity underlying medulloblastoma using whole-genome sequencing Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S6-P43  0.404
2012 Hodis E, Watson I, Theurillat J, Zou L, Place C, Nickerson E, Auclair D, Cibulskis K, Sivachenko A, Kryukov G, Stransky N, Ramos AH, Voet D, Lawrence MS, Stojanov P, ... ... Pugh T, et al. Abstract 5056: A glimpse into the somatic mutation landscape of melanoma through exome sequencing of 121 tumor-normal pairs Cancer Research. 72: 5056-5056. DOI: 10.1158/1538-7445.Am2012-5056  0.581
2012 Jones DT, Jaeger N, Cho Y, Pugh TJ, Rausch T, Stuetz A, Zichner T, Weischenfeldt J, Zapatka M, Benes V, Blake J, Northcott PA, Remke M, Witt H, Witt O, et al. Abstract 4872: ICGC PedBrain Tumor - Next-generation sequencing identifies novel subgroup-specific mutations and copy number aberrations in medulloblastoma Cancer Research. 72: 4872-4872. DOI: 10.1158/1538-7445.Am2012-4872  0.374
2012 Pugh TJ, Cho Y, Archer T, Weeraratne D, Jones DTW, Jaeger N, Auclair D, Cibulskis K, Lawrence MS, Ramos AH, Shefler E, Sivachenko A, Tamayo P, Mesirov JP, Gabriel SB, et al. Abstract 4868: Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations within a wide spectrum of genetic heterogeneity Cancer Research. 72: 4868-4868. DOI: 10.1158/1538-7445.Am2012-4868  0.513
2012 Cibulskis K, Sivachenko A, Hammerman P, Imaz I, Pugh T, Sougnez C, Winckler W, Gabriel S, Getz G. Abstract 3960: Rapid and efficient large-scale somatic mutation validation approaches for cancer genome sequencing Cancer Research. 72: 3960-3960. DOI: 10.1158/1538-7445.Am2012-3960  0.443
2012 Weeraratne SD, Archer T, Pugh TJ, Hargreaves D, Yu F, Kautzman A, Jones DTW, Jaeger N, Tamayo P, Mesirov JP, Pfister SM, Lichter P, Crabtree G, Meyerson M, Pomeroy SL, et al. Abstract 1313: Mutually exclusive somatic mutations in WNT pathway medulloblastomas reveal a critical interaction between DDX3X and SMARCA4 Cancer Research. 72: 1313-1313. DOI: 10.1158/1538-7445.Am2012-1313  0.484
2011 Bass AJ, Lawrence MS, Brace LE, Ramos AH, Drier Y, Cibulskis K, Sougnez C, Voet D, Saksena G, Sivachenko A, Jing R, Parkin M, Pugh T, Verhaak RG, Stransky N, et al. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nature Genetics. 43: 964-8. PMID 21892161 DOI: 10.1038/Ng.936  0.719
2011 Chapman MA, Lawrence MS, Keats JJ, Cibulskis K, Sougnez C, Schinzel AC, Harview CL, Brunet JP, Ahmann GJ, Adli M, Anderson KC, Ardlie KG, Auclair D, Baker A, Bergsagel PL, ... ... Pugh TJ, et al. Initial genome sequencing and analysis of multiple myeloma. Nature. 471: 467-72. PMID 21430775 DOI: 10.1038/Nature09837  0.534
2011 Jordan DM, Kiezun A, Baxter SM, Agarwala V, Green RC, Murray MF, Pugh T, Lebo MS, Rehm HL, Funke BH, Sunyaev SR. Development and validation of a computational method for assessment of missense variants in hypertrophic cardiomyopathy. American Journal of Human Genetics. 88: 183-92. PMID 21310275 DOI: 10.1016/J.Ajhg.2011.01.011  0.303
2011 Berger MF, Lawrence MS, Demichelis F, Drier Y, Cibulskis K, Sivachenko AY, Sboner A, Esgueva R, Pflueger D, Sougnez C, Onofrio R, Carter SL, Park K, Habegger L, Ambrogio L, ... ... Pugh TJ, et al. The genomic complexity of primary human prostate cancer. Nature. 470: 214-20. PMID 21307934 DOI: 10.1038/Nature09744  0.434
2011 Pugh TJ, Lawrence M, Sougnez C, Getz G, Attiyeh E, Hogarty M, Diskin S, Yael M, Diamond M, Asgharzadeh S, Sposto R, Wei JS, Badgett T, London WB, Gastier-Foster J, et al. Abstract 4756: Exome sequencing of 81 neuroblastomas identifies a wide diversity of somatic mutation Cancer Research. 71: 4756-4756. DOI: 10.1158/1538-7445.Am2011-4756  0.35
2011 Berger MF, Lawrence MS, Demichelis F, Drier Y, Cibulskis K, Sivachenko AY, Sboner A, Esgueva R, Pflueger D, Sougnez C, Onofrio R, Carter SL, Park K, Habegger L, Ambrogio L, ... ... Pugh TJ, et al. Abstract 3925: Characterization of complex chromosomal aberrations in prostate cancer from whole genome sequencing Cancer Research. 71: 3925-3925. DOI: 10.1158/1538-7445.Am2011-3925  0.477
2010 Griffith M, Griffith OL, Mwenifumbo J, Goya R, Morrissy AS, Morin RD, Corbett R, Tang MJ, Hou YC, Pugh TJ, Robertson G, Chittaranjan S, Ally A, Asano JK, Chan SY, et al. Alternative expression analysis by RNA sequencing. Nature Methods. 7: 843-7. PMID 20835245 DOI: 10.1038/Nmeth.1503  0.777
2010 Jones SJ, Laskin J, Li YY, Griffith OL, An J, Bilenky M, Butterfield YS, Cezard T, Chuah E, Corbett R, Fejes AP, Griffith M, Yee J, Martin M, Mayo M, ... ... Pugh TJ, et al. Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors. Genome Biology. 11: R82. PMID 20696054 DOI: 10.1186/Gb-2010-11-8-R82  0.702
2010 Jones SJ, Laskin J, Li YY, Griffith OL, An J, Bilenky M, Butterfield YS, Chuah E, Corbett R, Fejes A, Chan S, Liao N, Kasaian K, Griffith M, Yee J, ... ... Pugh TJ, et al. Personalized oncogenomics Genome Biology. 11: I5. DOI: 10.1186/gb-2010-11-s1-i5  0.629
2010 Jones SJ, Laskin J, Li YY, Griffith OL, An J, Bilenky M, Butterfield YS, Cezard T, Chuah E, Corbett R, Fejes A, Griffith M, Yee J, Martin M, Mayo M, ... ... Pugh TJ, et al. Genomic analysis of a rare human tumor Bmc Bioinformatics. 11. DOI: 10.1186/1471-2105-11-S4-O3  0.696
2009 Laskin JJ, Pugh T, Jackson C, Sutcliffe M, Ionescu D, Melosky B, Ho C, Sun S, Murray N, Marra M. Transcriptome-wide mutation discovery in patients in a phase II clinical trial of first-line erlotinib for clinically selected patients with advanced non-small cell lung cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 8102. PMID 27964273 DOI: 10.1200/Jco.2009.27.15_Suppl.8102  0.496
2009 Shah SP, Morin RD, Khattra J, Prentice L, Pugh T, Burleigh A, Delaney A, Gelmon K, Guliany R, Senz J, Steidl C, Holt RA, Jones S, Sun M, Leung G, et al. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature. 461: 809-13. PMID 19812674 DOI: 10.1038/Nature08489  0.695
2009 Pugh TJ, Keyes M, Barclay L, Delaney A, Krzywinski M, Thomas D, Novik K, Yang C, Agranovich A, McKenzie M, Morris WJ, Olive PL, Marra MA, Moore RA. Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 5008-16. PMID 19638463 DOI: 10.1158/1078-0432.Ccr-08-3357  0.445
2008 Morin R, Bainbridge M, Fejes A, Hirst M, Krzywinski M, Pugh T, McDonald H, Varhol R, Jones S, Marra M. Profiling the HeLa S3 transcriptome using randomly primed cDNA and massively parallel short-read sequencing. Biotechniques. 45: 81-94. PMID 18611170 DOI: 10.2144/000112900  0.633
2008 Pugh TJ, Delaney AD, Farnoud N, Flibotte S, Griffith M, Li HI, Qian H, Farinha P, Gascoyne RD, Marra MA. Impact of whole genome amplification on analysis of copy number variants. Nucleic Acids Research. 36: e80. PMID 18559357 DOI: 10.1093/Nar/Gkn378  0.587
2008 Zahir FR, Baross A, Delaney AD, Eydoux P, Fernandes ND, Pugh T, Marra MA, Friedman JM. A patient with vertebral, cognitive and behavioural abnormalities and a de novo deletion of NRXN1alpha. Journal of Medical Genetics. 45: 239-43. PMID 18057082 DOI: 10.1136/Jmg.2007.054437  0.458
2008 Griffith M, Tang MJ, Chan S, Asano JK, Ally A, Pugh T, Tai IT, Marra MA. M1982 Identification of Differentially Expressed Alternative mRNA Isoforms Associated with Chemotherapy Resistance in Colon Cancer Cell Lines Gastroenterology. 134: A-444. DOI: 10.1016/S0016-5085(08)62075-2  0.634
2008 Keyes M, Pugh T, Moore R, Pickles T, Marra M, Agranovich A, Barcla L, Delaney A, Morris WJ, Thomas D. Variants in DNA repair genes and their association with late side-effects in prostate brachytherapy patients Brachytherapy. 7: 122-123. DOI: 10.1016/J.Brachy.2008.02.094  0.428
2007 Krzywinski M, Bosdet I, Mathewson C, Wye N, Brebner J, Chiu R, Corbett R, Field M, Lee D, Pugh T, Volik S, Siddiqui A, Jones S, Schein J, Collins C, et al. A BAC clone fingerprinting approach to the detection of human genome rearrangements. Genome Biology. 8: R224. PMID 17953769 DOI: 10.1186/Gb-2007-8-10-R224  0.723
2007 Stratford AL, Habibi G, Astanehe A, Jiang H, Hu K, Park E, Shadeo A, Buys TP, Lam W, Pugh T, Marra M, Nielsen TO, Klinge U, Mertens PR, Aparicio S, et al. Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy. Breast Cancer Research : Bcr. 9: R61. PMID 17875215 DOI: 10.1186/Bcr1767  0.469
2007 Pugh TJ, Bebb G, Barclay L, Sutcliffe M, Fee J, Salski C, O'Connor R, Ho C, Murray N, Melosky B, English J, Vielkind J, Horsman D, Laskin JJ, Marra MA. Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung cancer patients. Bmc Cancer. 7: 128. PMID 17626639 DOI: 10.1186/1471-2407-7-128  0.423
2007 Laskin JJ, Pugh T, Barclay L, Sutcliffe M, Ionescu D, Lam S, Melosky B, Ho C, Murray N, Lee CW, Marra M. P3-108: Correlative genomics in a phase II clinical trial of first-line therapy of erlotinib for clinically selected patients with advanced non-small cell lung cancer Journal of Thoracic Oncology. 2: S725. DOI: 10.1097/01.Jto.0000284084.26665.47  0.484
2007 Pugh TJ, Delaney AD, Flibotte S, Farnoud N, Li I, Farinha P, Gascoyne RD, Marra MA. PD2-2-7: Two wrongs make a right: the use of whole genome amplification for pair-wise genome-wide copy number analysis of limited patient material Journal of Thoracic Oncology. 2: S442-S443. DOI: 10.1097/01.Jto.0000283361.52989.E3  0.38
2006 Friedman JM, Baross A, Delaney AD, Ally A, Arbour L, Armstrong L, Asano J, Bailey DK, Barber S, Birch P, Brown-John M, Cao M, Chan S, Charest DL, Farnoud N, ... ... Pugh TJ, et al. Oligonucleotide microarray analysis of genomic imbalance in children with mental retardation. American Journal of Human Genetics. 79: 500-13. PMID 16909388 DOI: 10.1086/507471  0.564
2006 Bebb DG, Pugh T, Sutcliffe M, Barclay L, Fee J, O’Connor R, Vielkind J, Murray N, Laskin JJ, Marra M. Previously documented mutations in the epidermal growth factor receptor (EGFR) gene in a non-small cell lung cancer (NSCLC) population treated with gefitinib are not associated with response Journal of Clinical Oncology. 24: 7163-7163. DOI: 10.1200/Jco.2006.24.18_Suppl.7163  0.52
2005 Bebb G, Pugh T, Ho C, Laskin J, Murray N, van Niekirk D, Sutcliffe M, Fee J, Brooks-Wilson A, Marra M. O-184 Asian ethnicity, somatic epidermal growth factor receptor (EGFR) mutations and response to gefitinib in non-small cell lung cancer patients treated in a North American setting Lung Cancer. 49: S61. DOI: 10.1016/S0169-5002(05)80318-6  0.418
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